|
|
| Record Information |
| Record ID |
20 |
| Pubmed ID |
28451790 |
| SNP |
|
| Gene ID |
3916 |
| Protein ID |
P11279 |
| Vaccine Adverse Events |
usual type vulvar intraepithelial neoplasia |
| Vaccine |
HPV16 E7 DNA vaccine |
| Gene Name |
LAMP1 |
| Official Symbol |
lysosomal associated membrane protein 1 [Homo sapiens (human)] |
| Aliases |
CD107a, LAMPA, LGP120 |
| Other Designations |
lysosome-associated membrane glycoprotein 1; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1 |
| Chromosome |
13 |
| Location |
13q34 |
| Annotation |
Chromosome 13 NC_000013.11 (113297239..113323672) |
| MIM |
153330 |
| DNA Sequence |
>NC_000013.11:113297239-113323672 Homo sapiens chromosome 13, GRCh38.p14 Primary Assembly
ACGTGACAAGCGCTGCCGGCCGCGGTGTCTTCTTCGTGCCGGCGTCGCAGTGGCCGGGCCTCTTGCGTCT
GGTAACGCCGCTGTCTCTAACGCCAGCCCTTGGCGCCCGCGCCCCGCCACCGCAGCGCCCGGCAGTCCGC
GGCCCAACCGCCGCCCGCGCCCCCGCTCCCCGCACCGTACCCGGCCGCCTCGCGCCATGGCGGCCCCCGG
CAGCGCCCGGCGACCCCTGCTGCTGCTACTGCTGTTGCTGCTGCTCGGTGAGGGGGTCGAGGCGGGGCCT
GGGAGCGGCGGGACCGGGCGGAGCCGAGGTCCCTGGGTCTTGAGGGCGGGGGACTGCCGGGTCGTTGTCC
CGCGGGTCGCCCCGCACCCACTGCTCCTGGTCCCGGCCGGCTCTGCCCGCGGGCGGGTGTTTCTCTCGGG
GTCGTAGGGTCGGAGCGGAGCTCAATGGCAGGTGCTTGGGGGACCAGGAGGTCTCATCCCAGGACCTGGC
TCCTCTAAGGTCTGTCTCACTGAACTCAGTTTTTCTGTGGTGGTGAGTGCGAAAGGGAACTTCCGATGGC
TTGCTCGGCGGTCTGGTGCTTTCAGGTCGTTAAGTTTCCTGGCAAGTTGAGGCGGTGAGATCTAGACGAG
GCTGCGCCGCCGAAGGTGGCAGGGACGTCTGTGGTCTCAGCTCCCGGGTGGGTGACCTAGATCAAGCTCT
TCCCAACATGGATTTCACCCAGGACAGGGAGAAGCCGGTGCGAGCATTCCCCACCTTTGTACTTGAACCT
TTCTCCTCTTTCAGCGGTGTGGAGGAGATGCGAGTGTATTTATGTTATTGTGAATTCACATGTATGTTAA
AATAATTTTTAAAGTTATCTTTGGGATTTCACAAGATTCCGTAGTAGACAAGATGAGGGAAAGCTGGCCT
CAGACTCACGGTGGCAATGTTCATGTCTAGTAAGTAGTTTAAAGAGCGCCGTTCCTGTAGGCCGAAATGC
GGGACCAGGGAACACGTGGGGAAGCACCCTTCTCTTCTGTCAGTTTATAGAGCTCAGATGGGCAGTAGGT
GCTCAATATTGTATTGACTAGTGAATTTCGTTCTCATTTATTGTCTTAATAAGAGGATGTGTGCTGTCTC
TTTAAGACAGTCCGGATTGCCCCCCGCCAACACTATTCTTTCACCTCCTCCCCCCGCCGCCCTCCCCCGT
AATATGAGAAGATTATCTTAAATGCCAGGATCTGAAAGGTGATGTAGAATCAAGCTGGGGGAGTGTGTGT
GAGTTAAGTAGATATAGAAATACACTCCTGTACACATCTGCCTTGACTTCTTTAAATCCCTCAGTCCCAT
CCAGCTGTAAAACTCTGTTACTGTGAGTGAATGGATCTTGGCTTCCCTTTTTTGTTTTGCCTGTTGTGTA
AAATGAATTCTTTGAACTGCCTGAATAGCCACAGAGATGAACTTATTCCAATAGTAAGCCTGAAGCCTTG
CTCAGCTCCTGCGACAGGGTCAGGTGTAGTTAATGAAAGGAGTTGCAGAAACAAGTTTTGTCATGTCACA
GCAACTGCATTGTTCTTTGTTACAGATGCTCACAAGCCTCATAACTTTGATGTTTTGTTTCATGTTTTAA
AAACTCACTTCAGGCCGGGAGCAGTGGCTCACGCCTTTAATCCCAACACTTTGGGTGGCCGAGGCAGATG
GATCATGGCGTCAGGAGTTCGAGACCAGCCTGGCCAATATGGCGAAACCCGGTCTCTACAAAAATACAAA
AATTAGCTGGGCATGGTGGCGCACGCCTGTAATCCCAGCTACTTGGTAGGCTGAGGCAGAAGAATTGCTT
GAACCCGGGAAGCAGAGGTTGCAGTGAGCTGAGATCAAGCCACTGCACTCCAGCCTGGGCAACTGAGGGA
GACTCCGTCTCAAAACAAAAAAAAAATTAACTTTAAAAATGAAGAGAAAAAATCCATAACTCCCTAATAT
TGTGATTGGAATATTGCTTGTGTAATCAGTCTTCTAAGATCTGTTCCATTATATCTTTTATGTTTACAAT
CTTAACTTTTTTTTTTTGAGGCGGAGTTGCTCTGTGCCCAGGCTGGAGTGCAGTGGCACAACCTCGGCTC
ACTACAACTTCTGCCTCCTGGGTTCGAGCAATTCTTCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGG
CACCCGCCACTATGCTAGGCTAATTTATGTATTTTTGGTAGAGACTAGGTTTAACTATGTTGGTTAGACT
GGTCTCGATCTCCCGACCTCGTGATCCGCCTCCCTCTGCCTCCCAAAGTGCTGGGAGTACGGGTTTGAGC
CACCGTACTTGGCCCAAGAATTTTTTTTTTTTTTTTTTGAGGCAGAGTCTCACTCTGTCACCCAGGCTGG
AGTGCAGTGGCGTGATCTCCGTTCACTGCAGCCTCCGCCTCTTGTGTTCAAGCAGTTCTCCTGCCTCAGC
CTCCCTAGTAGCTGGGACTACAGGTGCGCGCCACCATGCCTGGCTAATTTTTGTAGTTTTAGTAGAGATG
GGGTTTCACCATGCTGGCCAGGCTGGTCTCGAACTGACCTCGTGATCCACCTGCCTCAGACTCCCAAAGT
GCTGGGATTACAGCCATGAGCCACCGTGCCTAGCCAAAATCCAACTTTTAAAAAAGGCCTTTTAACAACT
TGCATTTAAAGATATTTAAAATGTTTATTTTAATGTGCGATTTCACCAAAAATCCTTTTTTCTTAAAAAA
AGAAACTGCTCAATTACAAATTTCCACTATATTAATAATTAGGCATTGTTTAAAGCTACTGTGTTTGAAT
ACTTAGAAAGCTCAAACATGAACTGAAACTTGTCCTGATAGATAGGATTAGCTGTGATTGCGTAATGTGA
CCCTTTAAACCATTGATGTCAGCAGGATGACCGCCTTACCCTTTCCACTTGAACAACTGTCACTTAGGAG
GTTTGAACAATTTTATACTCGGCTGGGTGCAGTGGTTCACGCCTGTAATCTCAGCACTTTGGGAGGCCCA
GGTGGGCGGATCAGCTGAAGTCAGGGGTTTGAGACCAGCCTGGCCAATGTGGTGAAACCCCGTCTCTACT
AAGAATACAAAAATTAGCCAGGCGTGGTGTGGTGGCAGGCGCCTGTAATTCCAGCTACGTGGGAGGCTGA
GGCAGGAGAATTGCTTGAACCTGGGAGGCAGGGGTTGCAGGGAGCTGAGATCGTGCCATTGCACTCCAGC
CTGGGCAACAAAATCGAAACTCAATGTCAAAAAAAAAAAAAAAAAAAGAAAAAGAAAAGAAAGAAAAGCT
GGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCCGATCACTAGGTCAAGA
GATCGAGACCATCCTGGCCACAACATGGTGAAACTCCATCTCTATTCTTTTTAAAAATATTTTTAAAAAG
TTAGCCAGGCGTAGTGGCACAGGCCTGTAGTCCCAGTTACTCAGGAGGCTGAGGCAGGAGAACTGCTTGA
ACCCGGAAGGTGGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCTCTTCAGGGCAACAGAGCGAGACTCC
ATCTCAAAAAAACAAAGAAAAAAATTTTTTTTCTACTAACCGATGTTACCTTTGATTGTGCAGATTGTCA
GTTATGCGGTGGAAAGAATGAATTTGTCAGCAGATTTGAGGTCAGAATGTCTTTGTAGCCCTGTAATTTT
GAATTTGTATTGCATTAGCCCCATCCCAGACAACGTTACCCTTTCTTCTCTGTACCCAAGACTTTTATTG
CATGTGCTTCTACATGGTAACATCTGTTCGGCTGCACTGGGATTATTTTTGCCTGTGTATCTCCCTTCCT
TAACTGACAGGTAGTAAGTGCTGAGTACATATATGAAGAAAGGATCAATTTTATAGCAGTGGCTCTCAAC
CAAACATATGCACGGATCCACACGATCAGCTTTTTAGAAATATACATACCACAGCGAGGCACAGTGGCTC
ATGCCTGTCATCTCAGTGCTTTGAGGCTAAGGCAGGAGGATTGCTTGAGATCAGCCTGGGCAACATGGCG
AGACCAGTGTCTCTACAAAAAAAATTAAAAAGAAATATACGGCCGGGCACGGTGGCTGTCACGTGTAATC
CTAACACTTTGGGAGGCCGAGGTGGGTGGATTGCCTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAATAT
GGTGAAATCCCATCTCTACTAAAATACAAAAAAAATTAGTCGGGCATGGTGGCGTACCCCTGTAGTCATA
GCTACTTGGAAGGCTGAGGTAGGAGAATTGCTTGAGCCCGGGAGGCGGAGGTTGCAGTGAGCGAAGATCA
TGCTACTGGACTCCAGCCTGGGTGACAGAGTGAGACTCTGTTTCCATTTAAAAAAAAAAAAAAAAAATAT
ATATATATATATATATATATATATATATATATATATATATATATTTACACACACACACACTTATACCTTG
CCTCTAGAGGTTGTGATTCAGTGCCTGGGATGGTATTTTTTTCCTTTAGTTCTTCATAAATGATTGTGCA
TCATTGGTTAAGTAGAATAAAAATACCATATTTAAAAGAATCAAGCCAAGAAAAACTAAGATGTGATTTC
TTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCGAT
CTCGGCTCACTGCAAGCTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTACCAGGG
ATTACAGGCATGCGCCACCATGCCCGGCTAATTTTGTATTTTTAGTGGTGACAGGGTTTCTCCATGTTTG
GTCAGGCTGGTCTCAAACGCCTAACCTCAGGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTAC
AGGCGGTAGCCACCACACCCAGCCTAAGATGTAATTTCTTAATAAATTGTTTTTTCTTCTTTTTTTGAGA
CAGTCTCTTTATGTTGTCCAGTCTGGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCCACCTCCCG
GGTTCAAGTGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGAGACTACAGGCATGCGCCACCATGCCCGTC
TAATTTTTGTATATATTTTTTAGTAGAGACGGGGTTTCACCATGCTAGCTAGGCTAGTCTCAAACTCCTG
ACCTCAGGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTGGGATTACGGGCTGTGCC
CGGCCTAATTTTTTAAAATGAAGTTTTTTACTCATTTCTTCAGATGGTAATCTTTAATGTCAAAAGCGAG
TATTTCTTAATTTTTATTTATTTTAATTCAAAAAAATTAAATTTTTTTTTTAAGAGACAAGGTCTTGCTG
TGTTGACCAGCCTGGTCTGGAACTCCTAACCTCAAGCAGTCCTCCGCTTCCTCAGCCTCCCAAAGTGCTG
AGATTACAGGCATGAGCCACTGCACCCAGCCAGTGTTTCCTCATTGGAAGCCCGTTCCCTCAGTCATCAA
GTGCTGGAGAGGCAGCGTGGCTCAGAAGTGGCACGTCCTGTGAGTCAGAAGACCCCTTCTAGATCTAGGT
CTCCGCCACTCACTAGCTGTGTGACCTGGGTGGGTTAGTTGACCTCTCTATGCCTTAATCTCCCTATGAA
GAGTTGTCATGATAACTGGGATGTGCTTAGAGCAGCACCTGGCACAAAGTAAGTGCATTCCAAGTGCTTG
TTAAATGAGATAGTTTTTGATGTTTTGTGTCAGATACTGAGGATTGAATGATGAACTTGATGGGAACCCT
CTGTACCTGTGCAGATGTTTAATAACAGCTGACATCAAAGCTGGCGTCAGTGCCGGGCACCAAATGCTCA
GCTGCTCCGACAGCCCTGAGGCCTTGGCACTCTCTCCTCCTGCTCGTGGGTGCAGAGACTGGGGATTGGG
CTCTGCTACTGGCCATGGTTGCACAGCTAGTAAGTGCTGCAAGAACCTCCAAGAACTGAGGGCTGTGACT
CAGAAGCACGCATGCTTCCCACAGCGGCACTTGTTTCAGAGAACAGAATTTCTCCCAAGTGGGGGTATTT
TGAAGCCACAGTTACTCCTTTATGTGATCCCTGGAGAAGTGGTCCTGTTCGTGTCTGAGTACAGGACTGC
CGGAGATAGCAGTCACCAGTAGGCCAGGGTGCCCACCTTGGAGATGCTGCCAACGGCTGTCCTGTTGGGC
TGTGACACCTGTCAGGTTACTGGAAACATTGTAACTTACTTGAGGTTTTTTGTCTTTTTTTTTTTTTGCT
ACCCAGTTGCCACTGTTGTGGAGGTTTTTAAAAAAACTTCTGACCCTTATAGCATACATACATTTCCTCC
TCAAGCTCTGTGTGCTGATGCTCTTATTTTCTTCTATACCAAAATTGCCTTCTGAGGGTAAGTTTATTTT
AATAACTCAAAATTCCTGGGTCTCTCCAGAGTAATACAGGCATCTTGTGCTGCCAAAGCTTACTTTAAAT
TTATTTAAATGATATTTCTTTGTTTTCCTCTGAAAGCTGAGACCTGGCTGGGCATGGTGGCTTACACCCA
TAATCCCAGCACTTTGTGAGGCTGAGGCAGGTGGATCACTTGAGGCGAGGAGTTGGAGACCAGCCTGGCC
AACATGGCAAAACCCTGTCTACCCCGTCTCTACTAAAAATACAAAAAGTAGCCAGACATGGTGGTACAAA
CCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCACGAGAATCGCTTGAACCTGGGAGGTGGAGGGCTACTG
CACTCCAGCCTGGGCAAGAGTGAGACTCAGTCTCTAAAAAATAAAAATAAAAAAGCTGAAACCCTCAGCA
TATTTACTAAGTGAAAAAAAAATTGTATAATTGAAAAATGACTTAGTTTGAAATATTTCCTAATGAAGTG
CTTCGGGTCAGTGAAAAGTGTTTGAGGAAACTTATAAAAGGGCAGCTTAATAAAAGCCAGCCTATGGCTG
CTCCCATGTGGGCATCCGGGTTGTCAGTGGTGACTGTGGGCCCTGTGACTCCTCACCTGAGGGCGGGGTG
GGCAGTCTCCCTGTCCACGCTGAGCTCCAGTCAAGTGTTAAGTCTCTGGCGTCTGCTGTGTCTGCCTGTC
CGCTGCTTCTGCCTTGCTGGCGTCTGCTGTAGCTTCTGTACACTCATCTGATCTTTCACAAGAGTGAGAA
TATTTTGTCTGTTTTTAGAAACCTTTACTATGTCAAAAATAAGTGGTAGAATCTTCCCTAGATTCTCTAG
ATTCATTGGAAATGCCGTTAGTATGATCCTGCCTCAGTGTTGCAGAGTGTGGCTTGAAAAACCAAGCAAA
GCAGACAGTAGATTGGAGGTTTCCTTGCACGCCCTACTTTGTTTCATTGTCGTGTAGCACCTTTTCTTTT
TCTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTTGTCACCCAGGCTGGAGGGCAGTGGTGCAATCTCGAC
TCACTGCAACCTCGGCCTCCCTGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCTAGTACCTGGGATTACA
GGCGCCTGCCACCATGCCCAGATAATTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTGGGTAGG
CTGGTCTTGAACTCCTGACTTCATGATCCACCTGCCTCAGCTTCCCACCAAAGTGCTGGGATTACAGGCG
TGAGCCACTGTGCCCGGCAGCACCTTTTCTTTATGGACATAGATTTTGGTATTTCCTTTACCAAAGGGAA
GATAGGTGGGACTACTTCTGGTTATATGCTTCGCTTTAGGCTTGAAGAACAGTTGCTGTAAAGATTTTAT
TTTGTGAAAGACCCAAGGTTGAAATGAGTCGGATTCATTGGAATCCATTACTTTTCCAGGGAATAGGATT
TTAAATGAAAAGCTAAGCATCCTCTCTTTCAATATCTGCCCTCACAGTGTGCCTGAGTTGCATTTACACT
TAGAGTGACAGATGAGACTCGGGTGTGTGTGTGGTTGGAAGGCTGTGCTCACGCAGTGTGAGATCAGCCC
CTGGGTGGTGAGTGCTCACTGGACTGGCATGCACGAACTTGTAGTGGCAGAGACAAGTGAAAGCATGTCA
TTTCTGCACGGATTCCAGTGGTGGCAGATAGGTGTTTGGCGTTAGAACAGGCAGAAACACCTGTTTTCCA
ATCTGTAATGAAAGAACTGTGTAATAACGTGCAATTTGTACAATTACCAGTGTCTCTACCGTAGTGATCA
GATTACATTTGTTGCCAAACATCTTGATCAGGGAAGTGGAGTATGAGTAAGTCAGAGAGGAAATATTTAG
CAGTGACCACTGTCCAGCTGGAAAGACCTATAGAGCTTCCATTCTGTCCCTTTGCTTCAGGATGGGGAAG
GGAAGCCACTCCACCGATGTGTAGTGCTGTGAGGACCTTTCTGAAATTGGGCAAAGAGCTCAGCACTTTG
AGTCCATGAGAAATAAAACTGACCAGACGTTAAGTAGCAGGTGAGGACCACAGTGAAAGATCCTGCAGCC
TCTCCCATGGATTTCTGCAGATGGGTGAGTTGTGCCTTCAAGGCACCACGTCTTACAGAGATCCTCTGAG
AAAGGCGGAACAGCGTATGCCTAGGATGATGCAGAAATTGACATGTGCCTTCCTGATAAGTGTTCTGGAA
TAAAGCACTAAATAGCAATAGACTAGGTTGGCAAACTCAATCAGATGGGCTTAGAGATAACAATTCCAGA
ATAGTATCCGAAAGGGACAGGGCACCAGGTGAACTGGCTGCGTAATCCATGTGTCTGGTTGTTCATTGAA
TTTAAGAAACACAGTGGAGGCTGGGTGCAGTGGCTGACACCTATAATCCCAGCACCTTGGGAGGCCAAGG
TGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAAGTGGCAAAACCCCGTCGCTACTAA
AAACAGAAATTAGCTGGGTTTGGTGGCACGTGCCTGCAGTTCCAGCTACTTGGGAGGCTGAGGCAGGAGA
ATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATCACGCCACTGCACCCCAGCCTGGCGACA
GTGAGACTCCGTCTCAAAAAAAAAAAAAGAGAAACAGTGGAATCTTGTAATAAAAGCCATCACTGCTACA
GCTGTGGAAAATGGAAATACTCGGTCGTATTTTCTGGACAGTTTTTGATGGTCTCCGTCTTCCCTGGAAT
TGACAGGCCTCATGCATTGTGCGTCAGCAGCAATGTTTATGGTGAAAAATGGCAACGGGACCGCGTGCAT
AATGGCCAACTTCTCTGCTGCCTTCTCAGTGAACTACGACACCAAGAGTGGCCCTAAGGTAGGAAACACC
AGGGCACTTCATGCTTCCCTTGTGTGTGTGGAAAGATGATTTTTAACATTTCAACCAAGTCTTTGAAAAA
TGGCCCCATCTGAACATGGTGCTTTTCCTATCTGCATATCTCCTTCTGGTGTTGTCAGTAACCTGCGCTG
TCATGTGCCATAGCCACAGGCACAGTAACAAACCTGTATATGTGCTGCACCTCACTGTTCATCATGAACA
TTTTCCTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTG
GCGCGATCTCTGCTCACTGCAAGCTCCGCCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCCAGT
AGCTGGGGCTACAGGCGCTCGCCACCACGCACAGCTAATATTTTGTATTTTTAGTAGAGATGGGGTTTCA
CTGTGTTAGCCTTGATGGTCTCAGTCTCCTGACCTCGTGATCCACCCGCCTTGGCCTCCCAAAGTGCTGG
GATTACAGGTGTGAGCCACCGCGCCCAGCCTATCATCAACATTTTTCTAGTTTTCTTTTTTTTTTTTGAG
ATGGAATCTTGGTTTGTCGCCCAGGCTGGAGTGCAGTGGTACGATCTGAGCTCGCCACAACCTCCGTCTC
CTGGGTTCAAGCAGTTCTCCTGCCTTAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCACCACCACGCCT
GGCTGATTTTTGTATTTTTGGTAGAGACGGGGTTTCACCATGTTGGCCAGGGTGGTCTCAAACTCCTGAC
CTCAAGTGATCTGCCTGCCTTGGCCTCCCAAAGTGTTGGAATTACAGGGGTGAGCCACCCCTCCCAGCTC
TAGTTTTCTTCGTGATTGTCTTTTATAATCATAATGTAATACTTTATTATGTTAATTCACCATAATTTGT
TACACACTCCCCTATTAGTAATTGGTAAGTTGTCTTGAATCTTTTTCATGCTCTGTGAATGTGGCTTTTT
TGATTTAGAGAGTTATACTGCAAGAAATGTATATAAATGGTTGGTTGACATGCAATGCAAACACTGTACT
AGTTTGATTAAAATGTTCCTTAGTGGTTTTGTTGAAATGGCTTTGTGTTTCTTTGGGATGACTAAAGCCT
TTTGGAATAACAAAATATTTTAAAAATCCAAGACATAGTAAGATCTTATCTCTTTTTTAAAAAAAAAAAA
AAAAGCCAGACATGGTGGAGTGTGCCTGTGGTCCCAGCTACTTGGGAGGCTGAGGTGGGAGGATTGCTTG
AGCCTGTGAGGTCGAGGCTGCAGTGAGCTATGATCTTGCCACTGCACTCCAGCCTGGGTGACAGAGCGAG
ACCATCTCCAAAAAAAAAAAAAAAAAAAAAAAATCCAGTCTCAAATTATAAATACTTGTCAAAGCCTTTT
TTCTTTTTTCTGAGACAGAGTTGCACTCTGTCCCCCAGGTGGCTGGAGTACAGTGCCAAGATCTCGGCTC
ACTGTGTCTTCCACCTCCCAGGTTTGAGTGAGTCTCGTGCCTCAGCCTCCTCAGTAGGTGGGACATCAGG
TGCATGCCACCATGGCCAGCTAATTATTTGTATTTTTAGTAGAGACGGGGTTTTGCTATGTTGGCCAGGC
TGGTCTTAAACTACTGGCCTCAAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTG
AGCTACCGTACCTGGCCTCCAAGCACTTTTTTTTTTTTTTTTTTTTTTTTTGAGGCAGAGTTTTGCTCTT
GTCACCCAGGCTGGAGTACAATGGCGCGTTCTTGGCTCACTGCAACCTCTGCCTCTTGGGTTCAAGCAAT
TCTTCTGCCTCAGCCTCCCAAGTAGCTAGGATTACAGGCATGCGCCCAGCTAATTTTTGTATTTTTAGTA
GAGACAGGGATTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCTTCCCACGTCGG
CCTCCCCAAGTGCTGGGATTACAGGCGTGGCCCAGCGTACCTGGTCTCCAAGCACTTTTTATTTAATTTC
TACATCACTTTTTTAATGTTTGGTTTTGGTGGTTGGATTTTTTAAATATTCTATTATAAATTATGTTTCA
CAAGTGAGGTCACCTATATGCTGTTATGCACTTTGTTATTTCACAGAACATGTCTTTATCACCTTGTGTA
GTTTCGTGTTGTTTTTTGGCCCACGTTAGTATACTGCTTCACTGTAGTTCATTTGACCTATCTAGTTTAC
TTTGATGAACATTAAGTGGTTTTCCAGTTGCTCGTTTTGCTTATAGTAGTAAATTTAAACATTTCTGCTA
TAAACACCTTCTTTGTTTAAAGAAACATTATTTAAATGAACATTTCTATAGTAAAAAAGTAGTGATAGCT
TTTCTCAAATATATATCTCACCCTGAAGCTGGTGTGAATTGTTTCAATTTCAAGACGCTTTAAATTCTGT
TATAAATTATATTAACATAAAATGAATTTATGGGGTTGTTTTGTTTTGTTTGGAGACAGAGTCTTGCTCT
GTTGCCCAGGCTGGAGTGCAGTGGTGCAGTCGTAGTTCACTGCAGCCTCAAACCTAGGCTCAAGCAATCC
TCCTGCCTCAGCCTCCTGAGTAGCTGGGACGACAGGCAGACACCACCATGTCTGATTAGTTTATTTTGTT
TTTGTAGAGATGGGGTCTTGCTATGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTCAAGCAATCCCCCCA
CCTCAGCCTCCCAGAGTGTTAGCATTACAGGTGTGAGCCACCATGCCCAGCTGCAAATTTTTGATTATAT
GAATTATTAAGCCAACTTTCTCTTACACCTGAAATACTTTTCAGTCTTTTACTGACATGTAATACTAACC
TTTTTTTGGTTTATATTAAAAATGAGTACCTCAGTAGTGATATCTTAGTTGGAAATGAAGTATAAGTTTA
TATCAGACTTACAGAAAATCTCTTTCTTTGAACTTTTAATAACCTGCATCCCAATTGGGTTACATTTAAT
TGTGTTTATTCTAGAACATGACCTTTGACCTGCCATCAGATGCCACAGTGGTGCTCAACCGCAGCTCCTG
TGGAAAAGAGAACACTTCTGACCCCAGTCTCGTGATTGCTTTTGGAAGAGGACATACACTCACTCTCAAT
TTCACGAGAAATGCAACACGTTACAGCGTCCAGCTCATGAGTTTTGTTTATAACTTGTCAGACACACACC
TTTTCCCCAATGCGAGCTCCAAAGGTAAGAACCAAAATGGGCCGATTATGAAGTGATAGAAAATTGGGTT
GGAGGATTGTCTAAAGTTACTTTTACCTAAGAAGTACAGGCTGGGTGTGGTGGCTCACACCTGTAATCCT
AGCACTTTGGGAGGCTAAGGCAGACAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATTG
CGAAACACTGTCTCTACTAAAAATACTAAAATTAGCCAGGTGTGGTGGCGGGCACCTGTAATCCCAGCTA
CTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATGGTGCC
ACTGCACTCCAGCCTAGGCGACCAAGTGAGACTGTCTCTAAAAAATAAAAAACACACAGCCAGGCGCGGT
GGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCATGAGGTCAGGAGTTCGAGAC
CAGCCTGATCAACATGGTGAAACCCCCTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCGCGC
GCCTGTAGTCCCAGCTACTCAGGAGGTTGAGGCAAGAGAATCGCCTGAACCCAGAAGGCGGAGGTTGCAG
TGAGCCGAGATCACGCCACTGTGCTCCAGCTTGGGCGACAGGGCGAGACTCTGTCTCAAAAAAAATAAAA
AACACATAAAGTAAACTAAGTACTATAAGTAGTTTGCAATTGTGATTTTTTTTTTTTAATCTAGAAATCA
AGACTGGAATCTATAACTGACATCAGGGCTAAAATAAAAAACACATAAACTAAGTACTGCAAGTAGTTTG
CAATTGTGATTTTTTTTTTTTTTAATCTAGAAATCAAGACTGTGGAATCTATAACTGACATCAGGGCAGA
TATAGATAAAAAATACAGATGTGTTAGTGGCACCCAGGTCCACATGAACAACGTGACCGTAACGCTCCAT
GATGCCACCATCCAGGCGTACCTTTCCAACAGCAGCTTCAGCCGGGGAGGTAGGACGCTGACCCTTGGCC
CTCTGGTGCTAGTGGTTGGGTAGCTGGGCTGCAGTGGCTGCGGGTGACCTCACTGCTCTGTGTCCTGGTG
CTGGGCTCTGCCTGGAACGCGTGTGCACACAGCCGGCGACGTCTCTGCAGAACGTTCTCATCCTTCTTCC
TAGGGCAGGTGACTTGTAGATGAGGGTAGACACATGTTGATTAAAAAGGGTGGAATATTGAAGTGAAATA
TCCCGGGACAGAGACAGATGTTGTGTGGTCTCCCGTGGGAGCTAAAGCAGTGGGAGTCGGCGGGGGGCGG
GTAGAGAGAGAGGTGATCACCAGGGGCTGGGGTTAAGTTGGTCAGAAGATAGAGCGTTTCCGGAAGACAG
GAGGAATTAGTACAGCATGTGACTGCAGTTAATAATGTATTCTGGCTTGAATATTGCTAAGTAGATTTTA
ACTCTTCTCACCATAAAAAAGTAAGTGTTTGATTTTAGCTGTCACACATGTAGGTGTATTTCAAAACATC
CTGACACACATGGTAAACGTATACAATTATTACTTGAAAATGTCAGAAGGGCAAAGCAGTTGAAACCTTT
GTGCTTCTACTGGGGCAGAGATGATGGGACCAGGGTCACAGATCTCTTGCAGTTTGAGCCAGTTGCCTTC
ACACAGAGACATAGTCTTATCTCCATCCAGCTCTGGCCGGCCAGCTTAGGGACAGGTGCAGAAAGACCAA
CGCTGCCTCTCTGAGGAGGTCAGGGCTGCGATGATGTACCTGCTAACCCAGCCGCCGGGCTCTGGGGTCA
GGCAGGGTCCAGGCCACCTCCTAGCCCTGTGATCTTGAGCAGGGTAGTTTACCTCTCATTTTCTTTGCAT
GTGGCATGAGATTAAAAGCCTGTCTTCAAAGGTTGTTGGAATTAAAAGAGAAATGTATGCAAAATGTGTA
TCTCAGCATCTGGCACAGAGTTAAGTAGCAAGCACCTGGTAAATCCTGTTACTTTTGAGGAGCTTCTCTC
CCGAGCCTCACAGTCCAGGTCATAGGTTGTTGTCATTTTGCTGAAGCGTGAGGGCCTGTGATTTGCCTTA
GGGTGAGCTTTCCCGGCTGATAGAAATATGTATGGAGACATCCCTTAGGGTGGGCTTTCCTGGCTGCTAG
AAATATATGGAGACATCACAGCCTTCTCTAATCTTGAGAGCTACTGTGGAGACCTTTGGTTTGCAACATT
CCTCAGCAGTCTTGCTTAAAGGCTGAGGAGTGACTGCTGGGCTCCACAGGAGGATCGTCCGTCTCACTCC
TCCCCGAGGAGCAGGTACTCTTGCAGGTCGGCACCCCATGGTGCTGGGCCGGTCTTGCCCACCTCCAATT
TCCATACAGCCCATGAGCTAAGAACGGCTTTTCGATTTATAAATGTAACATACCAAAAATCAGAAAACGA
ATATTTCTTGACACATAAAGATTATGTAAAATTCAGTGTCCATAAGTTAAATTTTCTTGGAACACAGCCA
CACTCATTTATTTACACATTATCTGTGGCTGCTTTTGTATTAACAGTGGCAGGGCTGTGTTGTCTTGACA
GAGAGCCACGGCCCACAAAGTCTGAAATATTTACTGTCTGTAGCTTTGCGGCAGACTTTGCCTTCCCTGG
TGAGTGGGTGAAAAGGAGCCCAACTTGGAAACCCCGGGTGTGACTGGGACTTGATGGGGCCACGTGGGCT
CCCATAGGGGAGGCTTGGAAGGAAACACACTTAGGAGCTGGGTCCTCTGTAGGTGCTGCTGCCTTTAATC
CTCAACACAGGGCCCCGGGGGCCGTGGTGACAGCCGCTTTCCTGGTGCAGCCTCTGTTCACACGGAGCCT
GGAGTCGTGTCTGCTTCATCAGGAAGAGCGGGCTAGAGTCCTCTCACATGGGCCGCGTGTGTCTGAGGAC
GGACGCCTGGCAGCCTGTCTAGGTGTGTTCATGCTCTCAGACACACCTCAGCCAGAGCTAAAGATAACTT
CAGCTAGGGGCAGTGCTCCCTACCAAGTGGGAGTTAGCGTAACACATGGGGGTGACTAGTGTTCACGGTT
ATCGATTTCCAAATTATCTGGGCTCCACACCTAGCTGGCTACCTCTGGGCTGCATCAATGTGGCTTGAAG
AGGAAAAGGAAGGGCACGCACTCTCTGTCAGAGCTTGGGAAATGAGAGAGAATTGGATGCTGACCTTGTC
CGGGGACTCCCTACTGGCTAGGCCTGGACACGGTTGCAGAACGTGTCTCCTCCCCATGTCGCTCTGTGAC
CGAGGGGTGCGCATGGCATGACCGCTCACTCACTCCTGCCTGGAAGTGAAGGGCTGCTAGGTGGAGGTCA
GCAAGGATGTTGAGTGCCCTGAGACGGGTGGCAGGATTCTCTAGATGAAAAATAAGGCTTCACAGGTCCA
GAGAAGCTTGCTAGGTTCTTTTGAGAAACCTGTTTCTTCAGGTTAATAATTACTTTTAAGATAGACTATT
TTTTAGAGCAGTCTTAGGTTTCTGTGTATTCTCTGCCGCTGCGCATGTACAGCCTTCCTCTGTGTCCAGA
TCCTGGACGTTGGTTCCTTTTTTAATGGAGAACACGCATGTGATTCCAAATGGAAAAAGGCCCGACAGCC
CAGCCCTGGCCACTTGCCCCTCCTGGAGGCAGCCAGTGTGGAGATGCCAGTGTGCCTGGGGCGTGGCCTC
CTAGAGGGAGTCAGTGTGGAGATGCCGGTGTGCCTGGGGCGTGGCCTCCTGGAGGGAACCAGTGTGGAGA
TGTCGGTGTGCCTGGGGTGTGGCCTCCTGGAGGGAGTCAGTGTGGAGATGCCCGTGTGCCTGGGGCATGG
CCTCCTGGAGGGAACCAGTGTGGAGATGTCAGTGTGCCTGGGGTGTGGCCTCCTGGAGGGAGTCAGTGTG
GAGATGCCCGTGTGCCTGGGGCATGGCCTCCTGGAGGGAACCAGTGTGGAGATGTCAGTGTGCCTGGGGC
GTGGCCTCCTGGAGGGAGTCAGTGTGGAGATGCCCGTGTGCCTGGGGCATGGCCTCCTGGAGGGAACCAG
CGTGGAGATGCCGGTGTGCCTGGGGCGTGGCCTCCTAGAGGGAGTCAGTGTGGAGATGCCCGTGTGCCTG
GGGCGTGGCCTCCTGGAGGGAACCAGTGTGGAGATGCCCGTGTGCCTGGGGCGTGGCCTCCTAGAGGGAG
TCAGTGTGGAGATGCCCGTGTGCCTGGGGCGTGGCCTCCTGGAGGGAACCAGTGTGGAGATGCCCGTGTG
CCTGGGGCGTGGCCTCCCGGAGGGAGTCAGTGTGGAGATGCCCGTGTGCCTGGGGCGTGGCCTACTAGAG
GGAGTCAGTGTGGAGATGCCCGTGTGCCTGGGGCGTGGCCTCCTGGAGGGAACCAGTGCGGAGATGTCGG
TGTGCCTGGGGCGTGGCCTCCCGGAGGGAGTCAGTGTGGAGATGTCGGTGTGCCTGGGGCGTGGCCTCCT
GGAGGGAGCCAGTGCGGAGATGCCCGTGTGCCTGGGGCGGGGCCTCCTGGAGGGAACCAGCGTGGAGATG
CCCATGTGCCTGGGGCGTGGCCTCCTAGAGGGAGTCAGTGTGGAGATGCCCGTGTGCCTGGGGCGTGGCC
TCCTGGAGGGAACCAGTGTGGAGATGCCAGTGTGCCTGGGGCGTGGCCTCCTAGAGGGAGTCAGTGTGGA
GATGCCCGTGTGCCTGGGGCGTGGCCTCCTGGAGGGAACCAGTGTGGAGATGTCGGTGTGCCTGGGGCGT
GGCCTCCTAGAGGGAGTCAGTGTGGAGATGCCCGTGTGCCTGGGGCGTGGCCTCCTGGAGGGAACCAGTG
TGGAGATGTCGGTGTGCCTGGGGCGTGGCCTCCTAGAGGGAGTCAGTGTGGAGATGCCCGTGTGCCTGGG
GCGTGGCCTCCTGGAGGGAACCAGTGTGGAGATGTCGGTGTGCCTGGGGCGTGGCCTCCTAGAGGGAGTC
AGTGTGGAGATGCCCATGTGCCTGGGGCGTGGCCTCCTGGAGGCAGCCAGTGTGGAGATGCCAGTGTGCC
TGGGGCGTGGCCTCCTAGAGGGAGTCAGTGTGGAGATGCCCGTGTGCCTGGGGCATGGCCTCCTGGAGGG
AACCAGTGTGGAGATGCCAGTGTGCCTGGGGCGTGGCCTCCTGAGGGAGTCAGTGTGGAGATGCCCGTGT
GCCTGGGGCGTGGCCTCCTGGAGGGAACCAGTGTGGAGATGTCGGTGTGTCTGGGGTGTGGCCTCCTAGA
GGGAACCAGTGTGGAGATGTCGGTGTGCCTGGGGCGTGGCCTCCTGGAGGGAGTCAGTGCGGAGATGCCC
GTGTGCCTGGGGCGTGGCCTCCCGGAGGGAGTCAGTGTGGAGATGCCCGTGTGCCTGGGGCGTGGCCTCC
TGGAGGGAGCCAGTGCGGAGATGCCAGTGTGCCTGGGGCGGGGCCTCCTGGAGGGAACCAGCGTGGAGAT
GCCGGTGTGCCTGGGGCGCGGCGTCCTGGAGGCTGGGCTTCCTGCCTGGGTGGCGCTTCACCAGAAAGCC
TCATGTATCTTGTCTTTTTTTTTTTTTTTTTTTTTTTTTGAGAGGGAGTCTTGCTCTGTTGCCCAGGCTG
GAGTGCGGTGGTGCCATCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTCCCTCAG
CCTCCTGAGTAGCTGGGATTACAGGTGCACATCACCACGTCTGGTTAATTTTTATATTTTTAGTAGAGGG
GGGCGTTGCACCATGTTGGCCAGGCTGGTCTTGAGCTCCTGACCTCCCAAAGTGCTGGGATTATAGGTGT
GAGCCACCGTGCCCGGCCCATCTTGCCTTTCAATACATCATCTTATCTAAAAAAGCTCGGGGACCTCATA
GATTTTATTTTAAAAGGAAATGAAGCACAAGCCACCTTTGAATGGACTTTCCTGTTGGTTTTGTACCTTC
CTTCCTGAGTATCTTCAAAGTAGGGCACATGTGGCTGGGCACGGTGGCTCAGTCCTGTAATCCCAGCACT
TTGGGAACTCGAGGTGGGTGGATCACCTCAGGTCAGGAATTCGAGACCAGCCTGGCCAACATGGCGAAAA
CCCGTCTCTACTAAAAATATAAAAATTAGTCGGGCGTGGTGGCAGGTGCCTGTAGTCCCCCCTACTCAGG
AGGCTGAGGCAGGAGAATTGCTTGAACCCGAGAGGTGGAGGTTGCAGTGAGCTGAGATCATGCTACTGCA
CTCCAGCCCAGCTGACAGAGTGAGATTCCATCTCAAAAACAAAAAAACAAAGTAGGGCAGATGACTGTCA
CTCCAGAGGGTCTGAGTGCAGCTCTGCCTGAGGCTGGAGTCAGCCAGATATCCATCCAAACCGGATTTCC
AGCCCAGGCCCATATGGGGTTAGCAGATCTACAGTGAGGCTCAGCCAGGCTTTTGGGTTTATGAGTTCAC
CGGGAGGAGTGGGGTGTCTTCGTCTTTTATCCTCAGGGTCTGATAGGTGCACGCTTGTTGAATGAATCAG
AGGACTGCCTGACTCCTGTTAGGAGTTGAAAATGAAGGTCACCGTGTCTCATCTCCCACCCAATTTGGCA
TGATTTTTTTTTTTTTTTTTTGAGGCAGAGTCCCGCTCTGTCACCCCAGGCTGGAGTGCAGTGGCGTGAT
CTCTGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTTCTGCCTCAGCCTCCCAAGTAGGTGGG
ACTGTAGGCGCCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTA
ACCAGGATGGTCTTGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAG
GCGTGAGCCACCGTGCCCAGCTGCAGCATTTTTTTTTCATTCCTAGGAACAGAGTCTGACTCCTAGCTTA
AATGGAAGGAATCGATGGTAAAACATTGGAGGTGGAGGTTGCAGTGAGCTGAGATGGCGCCGCTGCACTC
TAGCCTGGGTGGCAGAGCAACTGAGACTCTGTCTCAAAAAAAAAAAAAAAGAACTACCATCAGAAAGGCG
GAGAGGATGAGAGTCCCTCAGGACAGGTGAAAGGGGCAGGAGAAGGTCAGAGGCCTGACACACCCAACAT
TGTCACAAAAAACTGTAAGAGAGGCTGTGGGAGCTATGAGTCGGGAACCTGGGTGCAAACCAATCTCATC
CTCACAGACACCCTTGAGGGTCTGAATTGCAGCTTGCAGGTTGATGTGAGTATCTGCTGTTGCCGGGAGA
GGAGGAGGGGCCTTCAGAGCACATGAGCTTTGGAAAGGCCCGGCTGTGTGCTGCTCTCCGGAGGGTGCTG
GAGGAGGTGTGACAGTGGACCCTCAGGTCTCCCCAGAGGCTCCTGTGCCACCATCTCCCCCCGGGCAGCG
CAGGGCACTCTCCAGTGCGTTCCGTGATGAGCTCTCCGTCACTGTCCTCCGCCCTCAGCAGGAAAGACTT
TGGTATTTAGTACGCATTCAGGGAAGGAGAGTGTGGGTTTGCGTTTGTAATTCAGGTAGAAGGACGAGGG
CATTTTATCCACACTTATTTCTCAAGTTCCAGTTTTTTAAACTGGTGGTTAGACCTGATGATGTTTTATT
TGTGTTTCCAGCTTCTTGTGACCACTCTACAGAAACAGGGTGGGAAATGAATGTGCCACATGGATCACAG
GTGAAAAACAATTGTCAAAGCAGCGTAGGTTACACTTTTTCTGTGCGTCGTGTGGCCATCTAGACTAGAA
TTTGGACAAGACTGGCCGGTTTTGCACATTTAACTTTTGCCTGTTTAACCCTGGTCTGTAACATTTTATA
AAGGAACCGTGAAGCTGCTTTTTTTTTTTTTTTTTTGAGACAGGGTCTCCCAGGCTGGAGTGCAGTGGCA
CAATAACTGCTCACTGCAGCCTCAGCCTCCCAGGCTCCAGTGACCCTCCCTAGTCAGCCTTCTGAGTAGC
TAGGACTAAGGCGCATGCCACCATGCCTGGCTCATTTTTTAAAAAAACTTTGTGGAGATGGGGGTCTCCC
TATGTTGCCCAGGCTGGCCTTGAACTCCTGGGCTCAAGCAGTCCTCCTTCCTTGGCCTCTCAAAGCCCTG
GAATTACAGGCATGAGCCACTGCGCCCAGCAAGTGAAGCTGTTTTGGAAAGGACTGGTCAACCTGCAGCT
TCGCCAAGGGCAGTGAGCAAGGGTCCCTGAGCACATCCCAGGTTGGGACGGCTCCCAGTGGCCGTCAGTG
CCTCTCACTTCAGAGTTTGGTGTGGTTACTGCAGCTCCTCTCTGCCATCTTGTGCTCTGTCCAGAAGGGG
CTTTTACACCGGGGTGCGGGGGCACTCCTGTGTGTGTCTCAGAACCCGTTGGGGTGCAGTCATAGGCGAC
GTTGCCTGTCTCTTTCCTGCCCTGAGTAGATGGGATATGAAGGTGGGAATTGGCCACTGAATGTTGAGAT
GGAAGCGGAAGCAGCAGGTGACTGATGGAGTTATGAGTGGCAGATTCCCTGCAGGGTTGCCCACCCTGGA
TATGTGGGGCTCACGCGTGGTGACTCAGCCTAGCAGAGATGTGGAAAGGATCGAATTGGGTGGAAATTAT
ATAAATATTATTCTTGAGTATCCACAGAAACAAGGTGGTAAAAGAAAGAACCTGATTTCAAGGTTGATGG
TGTGTTAGTGAGAGTGTTGGCCACAGAAGACTCGGTAGAGCTCTACCTAGGGTTCAGTCTGTCTTGACTT
TGAATATAAATTTGTGTTGTGAACATCTTGGTGGGTGAATTGCTGAAGGACAGAGTCACATTCAGACTGC
TGGGCATTCCCCAGGGGTGCCATGTGCCCCCCCACCCCCACGGATTCCCTGAACTGTGCCCTCTTGTCTG
GGGATTTCAGACGCACCCACACTCACTGCCTTCTCCCTCGTGAGGATGCTTGCCCATCCCCCACAGCCCC
CTCCCCAAATGAAGACCCAACACAGCTGGCTAGCCTTGCCCGCCTTTGAGTCTCTGCTCACACGTGGGGT
CCTCATGGAGACTGCCTGACCCCTGTCCTGCCAGAGGGCCTCCTTGGCTGCTCTGCGTCCCACCTGGCCG
GTCTGTGTGTGCTGCAGACCCTCTGTTTCCCTCTGGGTAGTGTTTCCAGCACGATCCTGGCGCTCACCCG
ACAGCTCAGGGAGCAGTGTCTGAGTCGTCACCATTTCCCATGGGGTGAGGTGGCCGGCCACGCAGCACAG
CTTCCTGCGTCCACTCCTTCGTGACAGCGTTCAAGGCTTTCTCACCCTCACTTTAGGAAGAGGGTGGCAC
AGTGGCCCCTGTCCAGCCACGGGGCTTGGGGTGTGGTGGGCGGTGCCTGCTGCCCAGGCAGAACCGTCCT
GGGTAGTGGGAGGTGGAGGCTGAGGGTGCCCCACGGGCCTGTGCCTACCGCCCTGAGCCGTCTGCAGGAC
CCAGCTCTTTCCTGCGCGTCTAGAAAGGCATTAGCGAGAGCCACCTTGGGAGACTGAGAAAATAGTCACC
AAGGACGCCAGAGTCCACAGATGTAGTTTTGTTTCTGAGTTTGGATCTTACTGTAACTGCTGATGGTTAT
GAGAAACCCAGACCTGAATCTCCCTCCACTGCACCTGCAGAGACACGCTGTGAACAAGACAGGCCTTCCC
CAACCACAGCGCCCCCTGCGCCACCCAGCCCCTCGCCCTCACCCGTGCCCAAGAGCCCCTCTGTGGACAA
GTACAACGTGAGCGGCACCAACGGGACCTGCCTGCTGGCCAGCATGGGGCTGCAGCTGAACCTCACCTAT
GAGAGGAAGGACAACACGGTAGGGCTGGGGCCTCACCTGGGAGAGGGGGACGGCACGGTAGGGCTGGAGC
CTCTGCTCCCTGTGCACTGAGAACACGCGTCTCTGCACGTCATGCTGTTAAGTCAGGATGGGAGCTTAGC
TTGCAGGACGTGACCCTAGAGGACAAGAGCTGGCGTCTGTGTCAGTGAGTCCATTTTGTAGGATCACAGC
CGTCCTGCTGGTTCCATCATCCAAGGCTGGTGTCCCAGCATGGCCTATTGGGCAGTGTGGCCCACAGAGC
CTACAACTTGGCCCCTGATAGAACCTAAGTTTTCTTTACATATTTATCATGGAAACATTTAAGTGTTACA
TTTTTATAGTTTTCTTTTGAAATAGTTTTTCTCCCCTAGTAGTGACAGGCTGTGGGGTTGTGGGGGTCGA
CTTGCGTGCCGTGGGGTGAGTTTGCAGGGCTGACTGCTGCAGGGGGAGGTGGTGCTGCTGGTTGCCCTCC
ACGCGGGGACGCTGCACTCCAAGAGCAGCTGTCACGGGGTCAGGGAGAGTCATCTTGGGATCCCGAAATC
TGTACTAGTGTGGTCTTTCAGTGTTTTCCTTCTGGTTTTGGTTAAAACAAATGTGGCCTTGAATTCACGG
TTTCAGGACTGTTTGTCTTTTCGAGAGTGTGGAGGACCTGAGCTAGGGTGGTGACTTGCTTGCTTGTCTT
ATGCAGACGGTGACAAGGCTTCTCAACATCAACCCCAACAAGACCTCGGCCAGCGGGAGCTGCGGCGCCC
ACCTGGTGACTCTGGAGCTGCACAGCGAGGGCACCACCGTCCTGCTCTTCCAGTTCGGGATGGTGAGGCT
GGGGCGGCACCTCTCTGGGGGCGCCCACTGTGTCTCCACCACATCTTTTTGTGCCCTGGGTCTGCTCATG
GGAGGCAGCGTTAGGAAGGAGGCGGCCTCACTTTTTTCTGCCTTCCCTTTATCCTGGGCTTTTTAGTTCC
TTGGTTCCCCTCCCCCCTTTCCATTCCATTCATAGATGCAGCAGATGATGTGGGCGGGGCTGCTGTGCCC
ACAGTTGGAGTGGCTGCAGGGGAGGGCATGCAGGCCGTGCGGCCTTCTGGCTTCAGATGCTGCTGCCCTG
TGGTTCCGTGGTGGCATTTCTGCCTGGGAGGACTCCTGTGCAGTTAGCAACATAAGACATGAAGCATATA
ATTGTCACTTGTCAGTCTTTTTAAATCGCTGTGCAAATGAATTAACAGTTCAGTTTCTTATAATTTTAGC
TTTCCAAATCATGCTTTCCTGTGCTGTGATAGCTCCTGCAGTCCCCGTTTTCCAGAGACTGACTCTCAAG
AGGTCTGGAAGGACCAGCCTGGGCAGCACAGGGAGGCTCCATTTCTGCAAATAATAAAACGAGTTAGCTG
GGCGTAGTGGCGCACACCTGTGGTCCCAGCTACTTGGGAGGCTGAGGTGGGAGGATCACTTGAGCCCAGG
AGTTAAGGTTGCGATGAGCCGTGATCACTCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTCAGA
GAAGGGTCTGGAAGGAACTAACCAAAATTTTCATTCCCCAGAGATACACAACGCCTTTTATAGACAAGAT
CTTTTGCAGTTTTGTTCTAATACTAGAAATGTAGGAAGTCAGGTTTATTACCCAATGACCATTCACGTTT
GATGATAAATGTGTGAATCTACTGGGGTTAAAGATCATCTTTCTATGAATCTGCTCCGTGATTAAAGATC
ATTTTTCTTTTTAAGAATGCAAGTTCTAGCCGGTTTTTCCTACAAGGAATCCAGTTGAATACAATTCTTC
CTGACGCCAGAGGTGAGAACCCACAATCTCTGCGAGCCCCGCCCCCGCCCGCGCGCCCAGGGTATTCTGG
AGCCACTAGACCTCTGTGTGTGTTGCAGACCCTGCCTTTAAAGCTGCCAACGGCTCCCTGCGAGCGCTGC
AGGCCACAGTCGGCAATTCCTACAAGTGCAACGCGGAGGAGCACGTCCGTGTCACGAAGGCGTTTTCAGT
CAATATATTCAAAGTGTGGGTCCAGGCTTTCAAGGTGGAAGGTGGCCAGTTTGGCTCTGGTGAGTGTCAC
CGAGGGCAGCTGTCGCGGGGTGTGGAGGACGTGCTTCAGACTCCGCCTGTGGACGTTTAGTCGCTTCCGT
GTGGGCTGGGGCGACGCCCCTGTTCCTCTGCAAGGAGCTGTTTCTTCTTGCCGGTCTGAGATTCTAGAGG
TAACTCCCCCTGCTTTAGAGAGGCCCAGCGTGTCTCTCAGCTGGGAGCCCCTGGTACCATTTGAGAGTAA
GGGAATCATTTTAAGAAACAGTGGTGGCGCTTCTCCCATGAACGTTGAATACAACACTGTCATCTGATGT
GCACAGAGGCCCTGGACGCAGCACAGCTGTCCGGCCACAGCCCCTGATTCCAGACGGGGGAGAGACGTGT
GTGGTTTCCTCGCCGTGCAGAGAGCACCAGTCTCTGCAGCGGCTTCCCCAAGTGACAATTCCAGCTAGAG
CTGGAACCTTCCGCCAGGGTTCCTCTTTGCCTTTTGGCTGATGTGGGGGAGTGGTGGGGAGAGAGGCCTG
TTTGCAGGCCCCTGTGTGAGCAGAGCCCTGACACCATCCGTCTGTCTTGGCAGTGGAGGAGTGTCTGCTG
GACGAGAACAGCATGCTGATCCCCATCGCTGTGGGTGGTGCCCTGGCGGGGCTGGTCCTCATCGTCCTCA
TCGCCTACCTCGTCGGCAGGAAGAGGAGTCACGCAGGCTACCAGACTATCTAGCCTGGTGCACGCAGGCA
CAGCAGCTGCAGGGGCCTCTGTTCCTTTCTCTGGGCTTAGGGTCCTGTCGAAGGGGAGGCACACTTTCTG
GCAAACGTTTCTCAAATCTGCTTCATCCAATGTGAAGTTCATCTTGCAGCATTTACTATGCACAACAGAG
TAACTATCGAAATGACGGTGTTAATTTTGCTAACTGGGTTAAATATTTTGCTAACTGGTTAAACATTAAT
ATTTACCAAAGTAGGATTTTGAGGGTGGGGGTGCTCTCTCTGAGGGGGTGGGGGTGCCGCTGTCTCTGAG
GGGTGGGGGTGCCGCTGTCTCTGAGGGGTGGGGGTGCCGCTCTCTCTGAGGGGGTGGGGGTGCCGCTTTC
TCTGAGGGGGTGGGGGTGCCGCTCTCTCTGAGGGGGTGGGGGTGCTGCTCTCTCCGAGGGGTGGAATGCC
GCTGTCTCTGAGGGGTGGGGGTGCCGCTCTAAATTGGCTCCATATCATTTGAGTTTAGGGTTCTGGTGTT
TGGTTTCTTCATTCTTTACTGCACTCAGATTTAAGCCTTACAAAGGGAAAGCCTCTGGCCGTCACACGTA
GGACGCATGAAGGTCACTCGTGGTGAGGCTGACATGCTCACACATTACAACAGTAGAGAGGGAACATCCT
AAGACAGAGGAACTCCAGAGATGAGTGTCTGGAGCGCTTCAGTTCAGCTTTAAAGGCCAGGACGGGCCAC
ACGTGGCTGGCGGCCTCGTTCCAGTGGCGGCACGTCCTTGGGCGTCTCTAATGTCTGCAGCTCAAGGGCT
GGCACTTTTTTAAATATAAAAATGGGTGTTATTTTTATTTTTATTTGTAAAGTGATTTTTGGTCTTCTGT
TGACATTCGGGGTGATCCTGTTCTGCGCTGTGTACAATGTGAGATCGGTGCGTTCTCCTGATGTTTTGCC
GTGGCTTGGGGATTGTACACGGGACCAGCTCACGTAATGCATTGCCTGTAACAATGTAATAAAAAGCCTC
TTTCTTTTTGGGGTGGGCCTTGTCCTTCTGTCAGCTAAAATGGGAGCTCATGAGAGAAGGACGTCAGGGA
AACGGGGTTGAGGGTGGTCTCGGTGCAGAGAGAAGGGTGTCAGGGAAACGGGGGGTGAGGGTGGTCTTGG
TGCCAGACGTAGGGAATGGTGTTGGGAGTGGCCCGAGTGCCTGGCACAGTTGTCTGGTTCATTCATGTAA
CATGATAATTTTTAAATCATTAAAAAAATTACCTTTCATACAGA
|
| Protein Name |
LAMP1_HUMAN |
| Length |
417 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-JUL-1989 |
| Definition |
RecName: Full=Lysosome-associated membrane glycoprotein 1; Short=LAMP-1; Short=Lysosome-associated membrane protein 1; AltName: Full=CD107 antigen-like family member A; AltName: CD_antigen=CD107a; Flags: Precursor |
| Primary Accession |
P11279 |
| Accession Version |
P11279.3 |
| Other SeqIDs |
sp|P11279.3|LAMP1_HUMAN,gi|206729915 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Sep 26, 2008 this sequence version replaced gi:74751508, gi:74732020, gi:74732866, gi:74734291, P11279.2.; [FUNCTION] Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity). Also plays an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. {ECO:0000250|UniProtKB:P11438, ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23632890, ECO:0000269|PubMed:23847195}.; [FUNCTION] (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085). Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909). {ECO:0000269|PubMed:24970085, ECO:0000269|PubMed:29295909}.; [FUNCTION] (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. {ECO:0000269|PubMed:32295904}.; [SUBUNIT] (Microbial infection) Interacts with Lassa virus protein glycoprotein. {ECO:0000269|PubMed:24970085}.; [SUBUNIT] (Microbial infection) Interacts with mumps virus protein F; this interaction promotes protein F cleavage by FURIN. {ECO:0000269|PubMed:32295904}.; [SUBUNIT] Interacts with ABCB9; this interaction strongly stabilizes ABCB9 and protects ABCB9 against lysosomal degradation (PubMed:22641697). Interacts with FURIN (PubMed:32295904). {ECO:0000269|PubMed:22641697, ECO:0000269|PubMed:32295904}.; [INTERACTION] P11279; Q5VZM2: RRAGB; NbExp=2; IntAct=EBI-2805407, EBI-993049; P11279; Q6P1K1: SLC48A1; NbExp=3; IntAct=EBI-2805407, EBI-1222191; P11279; Q6UX27-3: VSTM1; NbExp=3; IntAct=EBI-2805407, EBI-12190699; P11279; P08669: GPC; Xeno; NbExp=4; IntAct=EBI-2805407, EBI-8411266.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23847195}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:16176980}; Single-pass type I membrane protein {ECO:0000255}. Cytolytic granule membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:24088571}; Single-pass type I membrane protein {ECO:0000255}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). {ECO:0000250|UniProtKB:P05300, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11279-1; Sequence=Displayed; Name=2; IsoId=P11279-2; Sequence=VSP_056032.; [PTM] O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells. {ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:24970085, ECO:0000269|PubMed:8323299}.; [SIMILARITY] Belongs to the LAMP family. {ECO:0000255|PROSITE-ProRule:PRU00740}. |
| Source Db |
UniProtKB: locus LAMP1_HUMAN, accession P11279;; class: standard.; extra accessions:B4DWL3,Q8WU33,Q96I40,Q9BRD2,Q9NP13; created: Jul 1, 1989.; sequence updated: Sep 23, 2008.; annotation updated: Oct 12, 2022.; xrefs: J04182.1, AAA60382.1, AK301584.1, BAG63075.1, AL136221.38, CH471085.1, EAX09202.1, BC006345.2, AAH06345.2, BC007845.2, AAH07845.2, BC021288.2, AAH21288.1, BC093044.1, AAH93044.1, J03263.1, AAA59524.1, AH003113.2, AAF66141.1, A31959, NP_005552.3; xrefs (non-sequence databases): CCDS:CCDS41909.1, AlphaFoldDB:P11279, SMR:P11279, BioGRID:110110, DIP:DIP-44670N, ELM:P11279, IntAct:P11279, MINT:P11279, STRING:9606.ENSP00000333298, TCDB:9.A.16.1.1, GlyConnect:355, GlyGen:P11279, iPTMnet:P11279, PhosphoSitePlus:P11279, SwissPalm:P11279, BioMuta:LAMP1, DMDM:206729915, EPD:P11279, jPOST:P11279, MassIVE:P11279, MaxQB:P11279, PaxDb:P11279, PeptideAtlas:P11279, PRIDE:P11279, ProteomicsDB:52734, ProteomicsDB:5353, TopDownProteomics:P11279-1, ABCD:P11279, Antibodypedia:2703, DNASU:3916, Ensembl:ENST00000332556.5, Ensembl:ENSP00000333298.4, Ensembl:ENSG00000185896.11, GeneID:3916, KEGG:hsa:3916, MANE-Select:ENST00000332556.5, UCSC:uc001vtm.2, CTD:3916, DisGeNET:3916, GeneCards:LAMP1, HGNC:6499, HPA:ENSG00000185896, MIM:153330, neXtProt:NX_P11279, OpenTargets:ENSG00000185896, PharmGKB:PA30283, VEuPathDB:HostDB:ENSG00000185896, eggNOG:KOG4818, GeneTree:ENSGT00950000182899, HOGENOM:CLU_055379_2_0_1, InParanoid:P11279, OMA:NSYKCSA, OrthoDB:993446at2759, PhylomeDB:P11279, TreeFam:TF316339, PathwayCommons:P11279, Reactome:R-HSA-6798695, SignaLink:P11279, BioGRID-ORCS:3916, ChiTaRS:LAMP1, GeneWiki:LAMP1, GenomeRNAi:3916, Pharos:P11279, PRO:PR:P11279, Proteomes:UP000005640, RNAct:P11279, Bgee:ENSG00000185896, ExpressionAtlas:P11279, Genevisible:P11279, GO:0044754, GO:0000421, GO:0035577, GO:0101004, GO:0005737, GO:0005829, GO:0010008, GO:0009897, GO:0070062, GO:0101003, GO:0005887, GO:0005770, GO:0031902, GO:0005765, GO:0005764, GO:0042470, GO:0016020, GO:0005771, GO:0048471, GO:0061474, GO:0005886, GO:0042383, GO:0008021, GO:0019899, GO:0019904, GO:0001618, GO:0072594, GO:0090160, GO:0140507, GO:0043323, GO:0045954, GO:0050821, GO:1902513, InterPro:IPR018134, InterPro:IPR002000, PANTHER:PTHR11506, Pfam:PF01299, PRINTS:PR00336, PROSITE:PS00310, PROSITE:PS00311, PROSITE:PS51407 |
| Sequence |
maapgsarrpllllllllllglmhcasaamfmvkngngtacimanfsaafsvnydtksgpknmtfdlpsdatvvlnrsscgkentsdpslviafgrghtltlnftrnatrysvqlmsfvynlsdthlfpnasskeiktvesitdiradidkkyrcvsgtqvhmnnvtvtlhdatiqaylsnssfsrgetrceqdrpspttappappspspspvpkspsvdkynvsgtngtcllasmglqlnltyerkdnttvtrllninpnktsasgscgahlvtlelhsegttvllfqfgmnasssrfflqgiqlntilpdardpafkaangslralqatvgnsykcnaeehvrvtkafsvnifkvwvqafkveggqfgsveeclldensmlipiavggalaglvlivliaylvgrkrshagyqti |
|
