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|
| Record Information |
| Record ID |
199 |
| Pubmed ID |
33139915 |
| SNP |
|
| Gene ID |
3002 |
| Protein ID |
P10144 |
| Vaccine Adverse Events |
|
| Vaccine |
SNP conjugate vaccines |
| Gene Name |
GZMB |
| Official Symbol |
granzyme B [Homo sapiens (human)] |
| Aliases |
C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT |
| Other Designations |
granzyme B; T-cell serine protease 1-3E; cathepsin G-like 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic serine protease B; fragmentin 2; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); human lymphocyte protein |
| Chromosome |
14 |
| Location |
14q12 |
| Annotation |
Chromosome 14 NC_000014.9 (24630954..24634190, complement) |
| MIM |
123910 |
| DNA Sequence |
>NC_000014.9:24630954-24634190 Homo sapiens chromosome 14, GRCh38.p14 Primary Assembly
TTTTCCACTCAGCTAAGAGGTATTTATTCAGTTGCTGGCACCTCTCCCAGTGTAAATCTGGACTTGGCTC
CAGAGAAGGTGTTTCATTACAGCGGGGGCTTAGTTTGCTTCCTGTAGTTAGTAGCGTTTCATGGTTTTCT
TTATCCAGTGTACAAAGCTTGAGACTTTGGTGCAGGCTCGTGGAGGCATGCCATTGTTTCGTCCATAGGA
GACAATGCCCTGGGCCACCTTGTTACACACAAGAGGGCCTCCAGAGTCCCCCTGTGAATAGAGAGTGGAA
GGACTGAGCTGATGCTCCTCCGGGTCCTGCCCTCTCTTCCATCTCAAGCCCCCTTTTAGAAAAGGCCAAC
TTGCACAGCCTACATGTGGGAGACCAGAGGGCAGGGCAGGCCGCTGGTGGCCCCCAGCTGCCAAGCTCTG
GCCCTGGACATTGTTACTGCTTCACCTCATCCCAGGGGCCAGCCTCCGTCATGTCCCCCAGATCCTGAGA
TCGGAGGTATGTGGGACCGTTGGCTGTTTAAGGACCCAGAAGTGGGCAAGGAGGGCTGATGTCCACCATG
GAGGACCAGCCCATTAACCACGTTGGGTACCAGCCTCTGAAGACACACCTGGTTATAATTACTGCACCCC
CAGTGGGCACAGTTTCCTAATATCTGTGACCTGGAGTGGGTGGAGTGTTGCAAATTCATCCTTCCAAAGA
AGCACCATCCACCATAAGCCTCCTGGTAAGTTTGCAGAGGCCCTAATTTCTCCCCAGCTCAGTCTAGTCC
CCTCTTCTCTTTCCAGAGAGAAATATCACAGTCTAGTGGGTGAAGGAGTCCCCCACTACTTGAGTCTCCA
GGTCTCAGATATTCCCCAAACATCTTTCTCCCAAGAGCCAATCCAGGCAGGTGCATAGTCTTACCTTAAA
GGAAGTCTTTTTAATCTCTGGGTCCCCCACGCACAACTCAATGGTACTGTCGTAATAATGGCGTAAGTCA
GATTCGCACTTTCGATCTTCCTGCACTGTCATCTTCACCTCTTGTAGTGTGTGTGAGTGTTTTCCCAGGG
GGGCCGTCTGCCCCCAGCCGGCCACACTGCATGTCTGCCCTGGCTTCACCTGGGCCTTGTTGCTAGGTAG
CCTGAGGGGCTGCACAGCTCTGGTCCGCTTGGCCTTTCTCTCCAGCTGGTGGGGAAGAGGCAAGAAAGTC
CAGGTCAGCCAACGAACTTCTGGGCCCCGACACAGTGATGGGGCTGCACAATCTTCCCTCTCCTCTGAGG
CATAGGAACTAACCAAGAGGCCAGGATGGAAAGGAGGGAAGGGCCGGCATTCCAGGGGGAGTGGAACCAA
CTGGACCAAGAAGAGCAAGAGTGGCAGGAGTGTGCCTCACCTGCAGTAGCATGATGTCGTTGGAGAAGTT
CTTAGGATTATAGGCTGGATGGGGGATGGGTCTTTTCACAGGGATAAACTGCTGGGTCGGCTCCTGTTCT
TTGATATTGTGGGCCCCCAAGGTGACATTTATGGAGCTGCACAGAGAGCAGAGTGAGGATGGGGGTGGAG
TCACAGGGTATACAGCCCAGAGACAGTGAAGAGCAGGTGACAGCTGGGGCAGGGCTGCAGCTGAGGGGAA
ATTAAGGGGACAGTCGGTCCCCAGGAATTGGAATTCTGGTAATTGCACCAGGTTTCTCAGGGTTCGGTTC
CCCCTAGAAACACAGGTGGAATTGCTTCAGTTTGTATTCTATGCCAAAGTATGCCCCCAGTTCTAAATAT
GGCAGGCTTGGTCACTCTGCTGTTTCTTACTTCAGCAGCACCTCTGGAACCAACCTTCCCCTCTCTCCAC
AAACTTAACTGCCCTTTTCTCACCCTCTAAGGAGACCTCCTGGCATGTGTGTTCACAGGAGCCCAGGGAG
CTCCTTGGGAAGAAGGCAGGGGTCTCTGTGGAGTGTTTCCAGGAGGGTGTGGGCTGTTTTCTGCTCCTCA
CCTTCCCCAACAGTGAGCAGCTGTCAGCACGAAGTCGTCTCGTATCAGGAAGCCACCGCACCTCTTCAGA
GACTTCTGATCCCAGATCATAAGATAAGCCATGTAGGGGCGGGAGTGGGGCTTGGCCTCATGTCCCCCGA
TGATCTCCCCTGAAGGAAAAGTCTGTCTGCTTGTGGGCACCCATGGAATCTGCTGGGTGGGCACCTGCTT
AGTGGCTCCAGAACTCCTGGGCATTTGGGAGCCTGGGATAGCCTGGAGTTGGGAGTGGCCTGGAGGAAGG
GGCTTCAATTTCCTGCTCTGAAAAAGGGAAGAACAGCAGACTTTGGTCTGTAAATCTTTCTTCCATATGT
AGTTGAAGGCGAGCATACCTGTCTTAGGGACAGTGAAATCCCAGAGGCTCCTGATCATTCCTCTCCTGAC
TTTGCTTTGTTTCAGGTGAGTTTCCAAGACCCTTATGAGTCCTGTGGTGTCTAGGATAGTGCTGCTTTCT
AATGGCCAGGGTGTAAGTGGAGGGATCTAGATACTGTCATATCCTGTTTCCTAGAGCCTGACATGTAGTG
GGTGCCCAGTAAATGTTCATGGCTGCATGATGGACTGGCTCCAGTTAGCCTCTGGATGAGGGCTGGTAGA
GCAGTGCTGGTGGAATTCTAGAAAGCAGGGAAGCTGGGGCCTGCCGTAGTGCCTCATCCTTGGAAAGAGG
GGAGCCACCAAAGGCCAGGGAAGAAAAGCAGAGTTGGAGAATGGGACTGAGCAAACACATTAACAGTGTT
CTGAGGACAGTGATTGTACCAATTCTGCTGTCAGCTGAGCTCTGGGTTTCTCTCCTAAGTAGACAGTGAG
AGAAGCACCTGTCTTATCCCAGAAACAGAAGCCAGGCCTACTCTAGAATAATTTAATATTTCTCTTTTCT
AGTTTCCCATCCTCTGCCATTTACTTCTAGGAAAGTCCTACTCTCCAGGTGACAAAGGTGGGCTCTGGGG
AAGGGATAGTACCCACTGGCTCTTCTTGAGAATGGCCTGCTGCTCTGCCATTCCTGCTGATAGCTTATCC
AGCATCACACTTGGGGGGTCTTGGTAGAATGGGAGCTGGAGTTCAGAACATTCCTGGTAGATAGATGGAT
CAGGAATGTGGAGAAAGGGCAGGAGACCTGTGGGATGGGGTTGGGCCCCCGAGGGTGGAGACGGTCACTC
ACCTGCATCTGCCCTGGGCAGCAGGAGGAAGGCCAGCAGAAGCAGGATTGGTTGCATCTTCTCAGGAAGG
CTGCCCTGGTTGGAGCT
|
| Protein Name |
GRAB_HUMAN |
| Length |
247 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-JUL-1989 |
| Definition |
RecName: Full=Granzyme B; AltName: Full=C11; AltName: Full=CTLA-1; AltName: Full=Cathepsin G-like 1; Short=CTSGL1; AltName: Full=Cytotoxic T-lymphocyte proteinase 2; Short=Lymphocyte protease; AltName: Full=Fragmentin-2; AltName: Full=Granzyme-2; AltName: Full=Human lymphocyte protein; Short=HLP; AltName: Full=SECT; AltName: Full=T-cell serine protease 1-3E; Flags: Precursor |
| Primary Accession |
P10144 |
| Accession Version |
P10144.2 |
| Other SeqIDs |
sp|P10144.2|GRAB_HUMAN,gi|317373361 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Jan 11, 2011 this sequence version replaced P10144.1.; [FUNCTION] Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3262682, PubMed:3263427, PubMed:1985927). It cleaves after Asp (PubMed:8258716, PubMed:1985927). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed:32188940, PubMed:31953257). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis (PubMed:9852092). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity). {ECO:0000250|UniProtKB:P04187, ECO:0000269|PubMed:1985927, ECO:0000269|PubMed:31953257, ECO:0000269|PubMed:32188940, ECO:0000269|PubMed:3262682, ECO:0000269|PubMed:3263427, ECO:0000269|PubMed:8258716, ECO:0000269|PubMed:9852092}.; [CATALYTIC ACTIVITY] Reaction=Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.; EC=3.4.21.79; Evidence={ECO:0000269|PubMed:1985927, ECO:0000269|PubMed:32188940, ECO:0000269|PubMed:8258716, ECO:0000269|PubMed:9852092}.; ACTIVITY REGULATION: Inactivated by the serine protease inhibitor diisopropylfluorophosphate. {ECO:0000269|PubMed:8258716}.; [INTERACTION] P10144; P14222: PRF1; NbExp=3; IntAct=EBI-2505785, EBI-724466; P10144; P10124: SRGN; NbExp=2; IntAct=EBI-2505785, EBI-744915.; [SUBCELLULAR LOCATION] Secreted {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:8258716}. Cytolytic granule {ECO:0000269|PubMed:1985927, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:8258716}. Note=Delivered into the target cell by perforin (PubMed:20038786). {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:8258716}.; [INDUCTION] By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes.; [SIMILARITY] Belongs to the peptidase S1 family. Granzyme subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}. |
| Source Db |
UniProtKB: locus GRAB_HUMAN, accession P10144;; class: standard.; extra accessions:Q8N1D2,Q9UCC1; created: Jul 1, 1989.; sequence updated: Jan 11, 2011.; annotation updated: Oct 12, 2022.; xrefs: M17016.1, AAA36627.1, J03189.1, AAA36603.1, J04071.1, AAA52118.1, J03072.1, AAB59528.1, M38193.1, AAA67124.1, M28879.1, AAA75490.1, AL136018.4, BC030195.1, AAH30195.1, A61021, NP_004122.2, 1FQ3_A, 1FQ3_B, 1IAU_A; xrefs (non-sequence databases): CCDS:CCDS9633.1, PDBsum:1FQ3, PDBsum:1IAU, AlphaFoldDB:P10144, SMR:P10144, BioGRID:109257, IntAct:P10144, MINT:P10144, STRING:9606.ENSP00000216341, BindingDB:P10144, ChEMBL:CHEMBL2316, GuidetoPHARMACOLOGY:2369, MEROPS:S01.010, GlyGen:P10144, iPTMnet:P10144, PhosphoSitePlus:P10144, BioMuta:GZMB, DMDM:317373361, jPOST:P10144, MassIVE:P10144, PaxDb:P10144, PeptideAtlas:P10144, PRIDE:P10144, ProteomicsDB:52569, ABCD:P10144, Antibodypedia:187, DNASU:3002, Ensembl:ENST00000216341.9, Ensembl:ENSP00000216341.4, Ensembl:ENSG00000100453.14, GeneID:3002, KEGG:hsa:3002, MANE-Select:ENST00000216341.9, UCSC:uc001wps.4, CTD:3002, DisGeNET:3002, GeneCards:GZMB, HGNC:4709, HPA:ENSG00000100453, MIM:123910, neXtProt:NX_P10144, OpenTargets:ENSG00000100453, VEuPathDB:HostDB:ENSG00000100453, eggNOG:KOG3627, GeneTree:ENSGT01030000234551, HOGENOM:CLU_006842_1_0_1, InParanoid:P10144, OMA:PAYNPEK, OrthoDB:1076876at2759, PhylomeDB:P10144, TreeFam:TF333630, BRENDA:3.4.21.79, PathwayCommons:P10144, Reactome:R-HSA-2197563, Reactome:R-HSA-5620971, Reactome:R-HSA-75108, SignaLink:P10144, SIGNOR:P10144, BioGRID-ORCS:3002, ChiTaRS:GZMB, EvolutionaryTrace:P10144, GeneWiki:GZMB, GenomeRNAi:3002, Pharos:P10144, PRO:PR:P10144, Proteomes:UP000005640, RNAct:P10144, Bgee:ENSG00000100453, ExpressionAtlas:P10144, Genevisible:P10144, GO:0044194, GO:0005737, GO:0005829, GO:0005576, GO:0001772, GO:0043231, GO:0016020, GO:0005739, GO:0005634, GO:0004252, GO:0008236, GO:0006915, GO:0019835, GO:0140507, GO:0042267, GO:0017148, GO:1900740, GO:0051603, GO:0070269, CDD:cd00190, Gene3D:2.40.10.10, InterPro:IPR009003, InterPro:IPR043504, InterPro:IPR001314, InterPro:IPR001254, InterPro:IPR018114, InterPro:IPR033116, Pfam:PF00089, PRINTS:PR00722, SMART:SM00020, SUPFAM:SSF50494, PROSITE:PS50240, PROSITE:PS00134, PROSITE:PS00135 |
| Sequence |
mqpillllaflllpradageiiggheakphsrpymaylmiwdqkslkrcggflirddfvltaahcwgssinvtlgahnikeqeptqqfipvkrpiphpaynpknfsndimllqlerkakrtravqplrlpsnkaqvkpgqtcsvagwgqtaplgkhshtlqevkmtvqedrkcesdlrhyydstielcvgdpeikktsfkgdsggplvcnkvaqgivsygrnngmppractkvssfvhwikktmkry |
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