|
|
| Record Information |
| Record ID |
198 |
| Pubmed ID |
33139915 |
| SNP |
|
| Gene ID |
6375 |
| Protein ID |
P47992 |
| Vaccine Adverse Events |
|
| Vaccine |
SNP conjugate vaccines |
| Gene Name |
XCL1 |
| Official Symbol |
X-C motif chemokine ligand 1 [Homo sapiens (human)] |
| Aliases |
ATAC, LPTN, LTN, SCM-1, SCM-1a, SCM1, SCM1A, SCYC1 |
| Other Designations |
lymphotactin; SCM-1-alpha; XC chemokine ligand 1; c motif chemokine 1; chemokine (C motif) ligand 1; cytokine SCM-1; lymphotaxin; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); small-inducible cytokine C1 |
| Chromosome |
1 |
| Location |
1q24.2 |
| Annotation |
Chromosome 1 NC_000001.11 (168576605..168582069) |
| MIM |
600250 |
| DNA Sequence |
>NC_000001.11:168576605-168582069 Homo sapiens chromosome 1, GRCh38.p14 Primary Assembly
ACTCTCCTTGCACAGCTCAGCAGGACCTCAGCCATGAGACTTCTCATCCTGGCCCTCCTTGGCATCTGCT
CTCTCACTGCATACATTGTGGAAGGTAAGTGGAGAAGCTGTCTGTGAGATAAAGAACAGGGAGGCAAGGC
AGGTGGGCACACATTTTGGGTTTGACTCAGGTTATGACTGGACTAACCTGCTTTCCCCAGGGGAGCCTTA
AACTTCCCATGTGCAAGAAAGGAATGATGATTTTGACTGTAGAGGGCTTCGTAAACTTCCAAAACAGGGA
GAATTTGATTAGTATCTGGGCTCCTACTTTTCCTAATTGGGTAATTTCAGGTAAATTCCTTAACCACTCA
GGGCCTGTGCTTATTTATGTATAACTGAATAGTATAACAGACATGATCACCTGAGATTAAGATTAAATAA
ATATTATGGTTTATTTAATAACATCAGATTTCCTTACAAGCAGTAATTTTTTGATTAATGTTAGCTATGG
ATTAGAGGTGATGATTATAAATGCATTTGTAGGTTTTGCCCATTTAATATATAGTTTGATAAATTATCAA
AATCTTAGAGAGTTCAGTTACAATGTGGGGATGCACCAGAGGATGTATGTTCTGGAGTAAATCAATGTTT
TCAATACAAAACTAAGCCCCAAATGACTGGAAGTTCAAACCTTCATGTCCAGAAAATCAATATTACCTTC
AAGTACGTGGGGGACTCTGTTAGTAATGCCATGACTATTACTATTTATGAGAAATTTTCTGTTTTTGTAA
GAGAACATACAATAATAACTACTACCAAATAGATCAGCACCTTATACACAGTTCAATAAACCTGCAAGAC
ACATCCAGGTAAGATTCAGATATACCGAGCCCTTACCTGAGCATTCAGTAGGTATTTCTTAAGGATTAAT
TTTTCCTATGACTGGAGTGAATCTGTCGACTTATTTGTGTTCTAGTTGGTAGGCTTATTACTTAGACTAT
GATATTATAACTTAATAATGGGTCCCCAAGGGGTTCCATGAATAAAGGTGGCTAAGTCTGGAAGTCCTTG
AAATTATGGATAAAACAAAAAAATACTGATGAAACAAAAGAGTTTGATTACTACATTAGGCCACATGTTG
CTACCTGGCTGGCATTTTGCTGAGACAATGGGCATACCATTTGAGGGAGACTCAGATCTGAGTAGGGGAA
AGGAGCTCTGTTAGAGGCTGAGAAGAACTGCAGACACTGGTCTCAAATTCCCAAGTTTTCTAGTTGAAGG
AGCTCTATAAGTCCCACTGGTGCTTAGCTTCTTACATACAAAAATGAGGGAAAACGGTCTCTGCTTTGAC
TCAATTTTGCAACCTGAGTGAAGGTGATATTTTAAAAAATAACACAGACACTCAAACATTGCTGACAATA
AGGAAAAGGCTTTGTGGTTTCAAGCATAACAGGATTCCCTGAGTCTTAGGAGTCCACTTCAGATACTTCA
CAGAGAGAAATATTGTTTCTTAAATATGAGAGAAACAGAGAAAAAACCCAGATTTTTCCTCTTTCATTGG
CTACAGAAACAATTCACCACTAAAAATAAATTGGCAAAGGTAGAGGATAGCAATGTGCAGACTGGCATTG
AGAGTGAAGAAATGATGAAGAAAAGCACACAATGAACACTCTTTGTTTAGTCCCTTGCTTTAAAAAATGC
CTTCTGATATTAGCAACACTACAGACCAATGTTGGCCATTATCAGTGGTTACTTTAGATGCTTTTTAGCT
GCCTATTTCCCTGGGAAGCAAAGACCAGTGTCTACAGCTAAGGAGAAAATCAGCACTTAGAAACTTGGAT
TAGATTTCACCCAACCCTTAACAGTATTAATTCTCCCAAGTTATTTTTCCTCTTGCAATGTAAGATGATT
CTCTACACTTAATAGTTTAATTCCTTTGGGCCATTACTATTGGGGATGCATATTTAAGGGCTGACTTCCT
TTTATATATATCTTACCTTTTACCATTTATTAATTTTTTGGAGAGTTTTTATTATTTTTATGTACAGAAA
ACTCAACAGTGTACATTTAACCCAGTTTAGTGGCAAGTTCCTCTGCCTTTGCTATTTCCAGCTTGGCATT
GTGAGCCACAGATTTTGGACTCGGGACATTGCAGATCTCATCATATCCGTCATTGTAATTTGTCCTGATA
GCTTCCACCAGCTTAGCCAAAGCTCCTTTGTCTTCCTGGTTAACTTGTGTGAAGGCCACAGTGGTGCTTC
CTGTGGACTGGATGTCCCAGTCTTGCCTTCTTACCCCTTGATAATGCATTAAGGGACCCCCCATTTTAGG
ACACAGGACAGACAGAAAGTTAACCAGCTTGATGGGGTCCACACCATGTGCAATACCAGCTGAGCCTTCT
TCTTTTCCAGCAAGGTGGTGATAGTGTTAACCCCTGCTCAAAGAACAGGTGATTTCCTAGTGGGGACAAC
CCCTTTGCTAGCAGCTTTCTTCTCAGCCTGGGCCAACAGTCTCTGCTTCTTCTCTTGCTTTGTCTCTGGT
CAGTACTTGTGGATCAGCTTAAGTGGCTGAGTAGCTGTTTGGGGGTCTAAGGCTTGGGTGAACTGGTTAA
TGGCAGAAGGCACTTTCAGCTGCTTATAGAGGATAGCTCTTTGCAGCTGGAACCAGATATAGCGGGGCCA
TTTCACAAAGCAGCGGAGGTCCCTTTTGGGCTGGATGTCCTGTCCAATGCCTGCCTAAGAAAACTCTTAG
GCCTTTTCTCACACAGCGGTTTCATCACTTTCTTAGCCTCCTGCTTCCTCACGACGGCAGGGTCTGGGGC
CACTTTCCTTCCTTTGGCCATCTTTCCTTTCAGCATCTTAGGCAGCTGACAGAGAGAGACATTTGACCAT
TTAAAAAGGAGAACACCTTTATTTAGTCTGTCAAAAGCATGCTTCCTTCCCTCACTGAATGTTGCCTTGC
CTAGAGTACTCTTCACGCATTACTCTGTCATCTCACTTATGGTACTGTAACATGTTGCACTATTTGAAAT
GATCTTTTCTGTTTGCCTGTCTGCTGCCTGGCTCCCTCATGAGAAGATATGCTCTATGAAAACAGGAGTA
ATGTCTGCTTAGTAAAACATGTGGGACACAACAGGCACCATTGTATAAATGAATGAATGCGTGTCACTGG
GGCATTTGCTAGCCGTCCCAAATGTCTAAGTGAAAATATACACAGAGACGGGATAACATCTTGTTATTTT
CTCTCAGCATGAAATTCCTGAAACAATTCTGTTGATTGAGTTTTTAAATTAGTCAAATATTTACTAAGAA
TCTGTGACGGGCAAGAGATTCGGGATGCCTATCAGTCCTCTCTTCCCCCAAAAAGCAAATGGCCTTAAAT
TCTCACAACATTCTCAGAGTAATTTAACAGATGATTGTTCCTGTGATCTGGATAATTGCTTTATTTTTAA
TTGTCTGTTGTTTTTTTTTCCTCACCAGGTGTAGGGAGTGAAGTCTCAGATAAGAGGACCTGTGTGAGCC
TCACTACCCAGCGACTGCCGGTTAGCAGAATCAAGACCTACACCATCACGGAAGGCTCCTTGAGAGCAGT
AATGTGAGTCTGCCTCCTCAGAAGTTGTGCTGGGTGGGTATCTAGAAGTATAGAAATACACTCTGTAGAA
ATGCTGCCGTCCTCAGGAAAAGTAGGTCAGCATAGAGGAACACCTCAACTTAACCAAAAACCTCTTTAGT
TTTCCTTATCAATCATGTCTTTCTGCAGCCCAACCGAATAGCGATTATTGCAGAAATTGGGCTGCCAAAG
AAAGAATAGAAGTCCTCCTCTATTTAGCTTAGTGGAAGAGTCTGTTGAATACTGTGCACAGCTCTGAGAC
CTGGGTTTAGAGATGACTGGCCCATGTCAGGGTTTCCCTGCAAGCCTCACTGGAGTTGGGGGATCTTAGG
GTTGAGTCAGGCAGAGTCCCATACTTTTATCAGTTGCCATATTTCAAGAAAATGAGTCAATGCACAACCT
ACATGGTCCCTTTCTTCTACCAGAATCTCATTTTTAGAAGTAATAACTCTTCTCAACATGTAATTGCAAG
CTTTACTCTAAAAAATGAAAATGTAAAAATCACTTTTTATTTAAAAAATAAGATGAATATTTTTAAATTT
GAAAAGGAAGAGGTTATGTAATAATGGAACTAGTTGGCCTCAAAGTCTTTTTGTTACAACATTTGGTGAC
ATGGATGAGAAAAGGACCCTGTGAATTATTGTGAACAAAGGGGCTGGATACTACTTGCAGATATTACTCC
TTTATGTTAAAATAGATGGCAGAAGAAGGGTACTCATTTATGATCTCATGGCTCTGAAAGACTATTTCTT
GCAGTAATTTCTGCACAAGATCTCTTCATGTCTGCCCTGATCTTAACTCCTGACCCTGAGGCTTTGAGAA
TGTGGCTAACTTCGTCTGTCTTTTCCTTGCGTTACAGTTTTATTACCAAACGTGGCCTAAAAGTCTGTGC
TGATCCACAAGCCACATGGGTGAGAGACGTGGTCAGGAGCATGGACAGGAAATCCAACACCAGAAATAAC
ATGATCCAGACCAAGCCAACAGGAACCCAGCAATCGACCAATACAGCTGTGACTCTGACTGGCTAGTAGT
CTCTGGCACCCTGTCCGTCTCCAGCCAGCCAGCTCATTTCACTTTACACGCTCATGGACTGAGTTTATAC
TCACCTTTTATGAAAGCACTGCATGAATAAAATTATTCCTTTGTATTTTTACTTTTAAATGTCTTCTGTA
TTCACTTATATGTTCTAATTAATAAATTATTTATTATTAAGAATAGTTCCCTAGTCTATTCATTATATTT
AGGGAAAGGTAGTGTATCATTGTTGTTTGATTTCTGACCTTGTACCTCTCTTTGATGGTAACCATAATGG
AAGAGATTCTGGCTAGTGTCTATCAGAGGTGAAAGCTATATCAATCTCTCTTAGAGTCCAGCTTGTAATG
GTTCTTTACACATCAGTCACAAGTTACAGCTGTGACAATGGCAACAATTTGAGATGTATTTCAACTTGTC
TCTATAATAGAATTCTGTTTATAGAATAAGGGAGAAAATAATCCAGTCTTCACTGGGTTCCCATTCTGAG
GGTCCACTACTCAAAAATTTGCTTCACTCAATTTTTTTCACCTCTTTGTGTTTTATTTTGGTGTCCTATT
AAAGGAATAAAATGACACAACTTGTCCCTTTTTTGTCCCATTAGCAAAAATTAGAATTTTGGTATAAAGA
AACTTTATTCAAGTAAAAATCAATACCCTTTGAATTGGACAATAATCTCACTACCTTATTAGGATTTCTG
TATTTGCCATTACGCTAGTTATCATGCATGTTATGCTTTACTGCGAATAAGCTTTTAATGCTCCAAATGC
TGACCCATGCAATATTTCCTCATGTGATCACAATTTGCAGTAAACTTTTAATTAAATGCTCATCTGGTAA
CTCAA
|
| Protein Name |
XCL1_HUMAN |
| Length |
114 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-FEB-1996 |
| Definition |
RecName: Full=Lymphotactin; AltName: Full=ATAC; AltName: Full=C motif chemokine 1; AltName: Full=Cytokine SCM-1; AltName: Full=Lymphotaxin; AltName: Full=SCM-1-alpha; AltName: Full=Small-inducible cytokine C1; AltName: Full=XC chemokine ligand 1; Flags: Precursor |
| Primary Accession |
P47992 |
| Accession Version |
P47992.1 |
| Other SeqIDs |
sp|P47992.1|XCL1_HUMAN,gi|1346471 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Jun 13, 2006 this sequence version replaced gi:74735882, gi:2144878.; [FUNCTION] Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. {ECO:0000250|UniProtKB:P47993}.; [INTERACTION] P47992; Q99616: CCL13; NbExp=2; IntAct=EBI-10209901, EBI-725342; P47992; Q9Y258: CCL26; NbExp=2; IntAct=EBI-10209901, EBI-7783416; P47992; P13501: CCL5; NbExp=3; IntAct=EBI-10209901, EBI-2848366; P47992; P48061: CXCL12; NbExp=2; IntAct=EBI-10209901, EBI-3913254; P47992; P02776: PF4; NbExp=2; IntAct=EBI-10209901, EBI-2565740; P47992; P10720: PF4V1; NbExp=2; IntAct=EBI-10209901, EBI-1223944.; [SUBCELLULAR LOCATION] Secreted.; [TISSUE SPECIFICITY] Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.; [SIMILARITY] Belongs to the intercrine gamma family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=XCL1 entry; URL='https://en.wikipedia.org/wiki/XCL1'. |
| Source Db |
UniProtKB: locus XCL1_HUMAN, accession P47992;; class: standard.; extra accessions:Q52MA8; created: Feb 1, 1996.; sequence updated: Feb 1, 1996.; annotation updated: Oct 12, 2022.; xrefs: U23772.1, AAC50164.1, D43768.1, BAA07825.1, X86474.1, CAA60198.1, D63790.1, BAA09859.1, AL031736.16, BC069817.1, AAH69817.1, BC070309.1, AAH70309.1, ETHUL, NP_002986.1, XP_011508167.1, 1J8I_A, 1J9O_A, 2HDM_A, 2JP1_A, 2JP1_B, 2N54_A, 2N54_B, 2NYZ_D, 2NYZ_E; xrefs (non-sequence databases): CCDS:CCDS1274.1, PDBsum:1J8I, PDBsum:1J9O, PDBsum:2HDM, PDBsum:2JP1, PDBsum:2N54, PDBsum:2NYZ, AlphaFoldDB:P47992, BMRB:P47992, SMR:P47992, BioGRID:112277, DIP:DIP-29876N, IntAct:P47992, STRING:9606.ENSP00000356792, MoonDB:P47992, MoonProt:P47992, GlyGen:P47992, PhosphoSitePlus:P47992, BioMuta:XCL1, DMDM:1346471, MassIVE:P47992, PaxDb:P47992, PeptideAtlas:P47992, PRIDE:P47992, Antibodypedia:20539, DNASU:6375, Ensembl:ENST00000367818.4, Ensembl:ENSP00000356792.3, Ensembl:ENSG00000143184.5, GeneID:6375, KEGG:hsa:6375, MANE-Select:ENST00000367818.4, UCSC:uc001gfo.2, CTD:6375, DisGeNET:6375, GeneCards:XCL1, HGNC:10645, HPA:ENSG00000143184, MIM:600250, neXtProt:NX_P47992, OpenTargets:ENSG00000143184, PharmGKB:PA35575, VEuPathDB:HostDB:ENSG00000143184, eggNOG:ENOG502S6ZP, GeneTree:ENSGT01060000248576, HOGENOM:CLU_141716_2_0_1, InParanoid:P47992, OMA:GIKICAD, OrthoDB:1553663at2759, PhylomeDB:P47992, TreeFam:TF334888, PathwayCommons:P47992, Reactome:R-HSA-380108, Reactome:R-HSA-416476, SignaLink:P47992, SIGNOR:P47992, BioGRID-ORCS:6375, EvolutionaryTrace:P47992, GenomeRNAi:6375, Pharos:P47992, PRO:PR:P47992, Proteomes:UP000005640, RNAct:P47992, Bgee:ENSG00000143184, Genevisible:P47992, GO:0005576, GO:0005615, GO:0048020, GO:0008009, GO:0042379, GO:0042803, GO:0061844, GO:0007267, GO:0071346, GO:0071347, GO:0071353, GO:0071560, GO:0071356, GO:0070098, GO:0007186, GO:0006954, GO:0031640, GO:0048247, GO:0035782, GO:0002548, GO:2000562, GO:0043433, GO:0045892, GO:0032689, GO:0032703, GO:0002725, GO:2000518, GO:0002826, GO:0030593, GO:2000538, GO:2000563, GO:2000566, GO:0070374, GO:2000513, GO:0071663, GO:0043547, GO:2000558, GO:0032733, GO:0002690, GO:2000503, GO:0090023, GO:0051281, GO:0010820, GO:0002726, GO:0001916, GO:2000556, GO:2000553, GO:2000412, GO:0071636, GO:0050727, GO:0051209, GO:0009615, GO:0007165, CDD:cd00271, DisProt:DP02957, InterPro:IPR039809, InterPro:IPR001811, InterPro:IPR008105, InterPro:IPR036048, PANTHER:PTHR12015, PANTHER:PTHR12015:SF101, Pfam:PF00048, PRINTS:PR01731, SMART:SM00199, SUPFAM:SSF54117 |
| Sequence |
mrllilallgicsltayivegvgsevsdkrtcvslttqrlpvsriktytitegslravifitkrglkvcadpqatwvrdvvrsmdrksntrnnmiqtkptgtqqstntavtltg |
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