|
|
| Record Information |
| Record ID |
197 |
| Pubmed ID |
33139915 |
| SNP |
|
| Gene ID |
114836 |
| Protein ID |
Q96DU3 |
| Vaccine Adverse Events |
|
| Vaccine |
SNP conjugate vaccines |
| Gene Name |
SLAMF6 |
| Official Symbol |
SLAM family member 6 [Homo sapiens (human)] |
| Aliases |
CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000 |
| Other Designations |
SLAM family member 6; NK-T-B-antigen; NTBA receptor; activating NK receptor; natural killer-, T- and B-cell antigen |
| Chromosome |
1 |
| Location |
1q23.2-q23.3 |
| Annotation |
Chromosome 1 NC_000001.11 (160485036..160523255, complement) |
| MIM |
606446 |
| DNA Sequence |
>NC_000001.11:160485036-160523255 Homo sapiens chromosome 1, GRCh38.p14 Primary Assembly
TCTATTTCATTTTATTTTATTTATTTATTTTTTGAGACAGAGTCTCACTCTGTCACCCAGACTGGAATAC
ATTGGCATGATTTTGGCTCACTGGAACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGTCTCTC
AAGTAGCTGGGATTTTAGGGGTGCACCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAAAGACGGGG
TTTCACCAAGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTCCCCCCTTGGCCTCCCAAAG
TACAGGGATTACAGGTGTGAGCCACCATGCCCAGCCTAGAAGATTCATTTTAGAAAGAGTGGTCTGGGAA
GGTTTCTCTTAGGAGGTGACATATTTAAAATTAAACCTAAAGAATAGGAGGACCCCAGCAGGCAGAGGAA
GGGCCTGCAGGAAGATGTAAATAATTAACATAAAGAACTTTTCCTTTAATAGAGGAGCTGAAAGAAGATC
AGGGAGGCTACATAGAGAGTGTCAGAAGGGTAATGCTAGCTGAGGCTGGAGGTGGGCCAGACCATCCAGG
GCCATGGAAACTGGATTTCTTTCTGAGTGCATTGGGAAACCTGCAGGGTTTTAAGCAGGAAACTGAAGGA
TCCAATTTATATTAAAAACATTACTCTGGCCATCTTGTGGAGAGTGGGTTGGAGAGGGACAAGAACAAAA
GTGAGGACAACTGTTCTGATCTTAAGGTAGGATTCAGGTTAGAGGTGGTGATGGTTGGATACAGGATGGT
GGTCAAGGAGTTGGAGGAGAAGTGGAAGGTCCAAGAAATATTTCTGAGGTAGAGTCCAAAGGGCCTGGTG
ACAAAGACACTGGAGTCAGGGATGACTTAGATTCTTGGCTCAAACAATGGAGCTGATGTAATACCATCCT
CTTCCTTTTTCAGTCTGGGAGACTAAGGCTCCAAAAGGTTAGGCAGTATGTCCCAGGAGATGTGTCTAAT
AAACATTGTACAAGTTGAGCATCCCAAATCCAAAAATCCAATATCCAAAATGCTCCAAAATCTGAGATTT
TGAGCACTGCATCGACATCAATGAAACTCAAGGGAAATGCTTATTGGAGCATTTTGAATTTTGGATTTTT
GGATTTGGATACTCAACCGCTAAATATAATGCAAATATTCCAAAATCTGAAAAAAAATTGAAATCTGAAA
CATTTCTAATCCCAAGCATTTCAGACAAGGGATGCTCAACTTGTATCAGGATGGGCCCATCCAACTCCAG
AGACTACACATGTAACCAACACACTGCATTATTTCTCAATAAGTCAATCCTGCTGCTTTCTAAAAGGAGA
GAAGTGGTTGTCTTCTGGATCATAAACTCTCTGTCAACCATAATTCCATTTGCTTAGTTATCAAAGAGAG
AGTCAATGTGCTGGTGTGTTATCTTTAGCATGTTTTGGCCTGAAGTGGATTGGAAAATATTATTTGAACC
ACATGCTGGAAATGATGTTATCCTTAGGTGTTTGACTCAGGTAGGCAGGTTTAAGTCCGAAGGACTGGAG
GTGATCATCCTATCCTAGATATTCAAATTCTGTTGCCAGGAACAACAGGAACCAAGCTTCCTGTTCTTTG
TTCTGTCTCATGGGATCAGAAGACGTGTCATTCCCGAATTCCTCTGAGGCCTTTCAGCAACTTACACGAC
ATTGTCAAGGGCAGTTGCCCTGGAAAAAGTGGGTTTACTCTGTGGGAAAAAGAGGAAGATGAGGTAGGTT
AATTGGAACTGGAACCTCAGCCCACCCCTCATAACTACAGAGAGAGGACTGGAGACTACAGAGAGGCAGA
TAATAGAGATATTGATAGCATAGGGCAGGATTAAATTTAAAAACATGTAATTGAAAACTCAGTTATGCAT
GGTGATCCTAATACAAAATAACTTCTTGATTATGTTTTGGTGATGTCCTGAGACTTTCCGCATGCTGCTG
CTGTTTGTGCATCTGTAAAATGACCCTTTTATTTTTACTTTATTTGAAAAATCATAGGTCTGTGGAGAGA
GGTAAGAATATAAAAACATGGAGCAATCGTGGGCTTACCTCTTTGGAATGATTAATTGTGGAGTAAATTG
TGATAGTATCATTTTCTCTAGGTGTCCAGATTTCTGTTTCCTGTAAAAAGAATCATACCAATTTGGCTTA
CACAGAGACAAAGAGATTAATGCATAGATATATTCTTAGGAAAGACTGTGTGACAAAAAAGAGAATATGT
CAAAGTTCTTCCAGAGGAAGGCTGGGGAATGTTCAGTGGAAGACCAAGCACGACTAGCTATCAAACTTGT
GAGGATTTAGTGGCATTTCCTGAGCCCCAAACAGAACAGCAACACTGCAGCAAACCAATGGGCTCAAGAG
CCAGAGAAAGGCAGCCTTGCTGTATGAAGGGAAGGAAGTATTCTTGTCCTTTGTCCAGCTCTACTTTCCT
TCCTCCATTTTTAAGAAAAAACTTATATACCAGATAGTTTATTATATGTTTTGTCTCAAATTTTTACTAG
CTATGACTGAAACTACCCATTTTGCCTGCTCCATCTTTTGCTATAATTCTAACTGCCTTGTCATCATGTC
ATTGGGGTCTTCTCAAGCATGGGGAATTGGTAGAATAGGAACACTTGGCCTTAAGAATGGCTCTGCCTGG
AATGCACATTACAGAAATAATAGCAGAAGTCCCTACGGCCCTCAAAGAACCTACTCAAAGATTTTGACAC
TTTAAATTAATGAAGAAGTATTTAGAGAATTATCAAGATCTCTACTGGGCACAGTGGCTCATGCCTGTAA
ACCCAACACTTTGGGAGGACGAGGCAGGCGGATCACTTGAGCGCAGAAGTTTGAGACCAGCCTGGGCAAC
ATGGTGAAACCCCGTCTCTACAAAAAGTAGAAAAATTATCCTGATGTGATGGTGCTCGCCTGTAGTCGCA
GCTACTTGGGAGGCCAAGGTAAAAGGATCACCTGAGCATGAGGAGGTTGAGGCTGCAGTGAGCTGTGATT
GTGCTACTGCACTCAGCCCTTGGTGACAGAGTGACACTCTGTCTCAAAAAAAAAAAAAAACCAAAAAACA
AAAAACAAACCAACAAAAAACAAAAAAACCTCAAACTCTCCAAAGCACATTTTTTTTTTCTTTTTGCTAA
AGAGAAAGCTAACCAATTTGTGGGAAATTAGTTTTTTGATTTGTCAGAGTGTGAGTTGACTTGTTTTCAG
GAGGAATTTGCAAAGGCAAAAGAAATGTCTGAGCAAGTGAGAGTACCCCTTCTTGCTTCCTGTCATCAAG
GATCATACTTTGCAAATATAGGTGAAGGGAATCCAAGATTTCTAGCTAGATCATTGCTTACATCATTTTG
AAAATGCTAAGCTTTCCTGGCTTATTTTTCAGAAAACTGGCCTCTCAAAATGTATGGTATTATTTAGAGA
TGTGCCACCTGCAGGTCCTTTATTTAGGGGTGGTGGGGAGTTGCTGATACATGACAGATGAGTTGCTGAT
GCTTGACCAGCCATCCTGTTATGCTGCTAGATGAGAGGGGAGGGGTGAACCATTGCTCATGGTTTAGTGG
CCTCTACTGTGCCCCCTTCCCCTCTTGAGAGACTACTTCTGAACTCCCCTAAGACCCCTACATGCAGAGT
GAGAAGTCAGCCACCTGCTATGGAACTACGTCCATAGGAAACTTTCAAACTTAGTGGAACTCTGACCCAT
TCAGCAAGTATTTACTGATCATTATGCTAGGATATAGGGCAAGAGAGAGGAAGACATAATTTGTACTTTC
AGTCAGCTTGTAATTAAGCTGAAGGGACAAGACTTACTGATGCATCAAGCGGTTGGAGAACTGTGTAAGG
CAGGGTATGAATAAACATTCCCTTAAGGGTGAGAAAGGCAGACACCAGAGTGGTCTAGCGCATAACTTTG
CAGCCCCTGTCGCTGTGGCTGTCTTCTCCTCCCCTCAGTGGTCATTTGTTCAGTCAGATGGTTATGGTGA
CAAGTTTGTGAACAATGGCTGTAAAACTGACAACAATGGCATATAAAGCTGAAAAGACTCACCCTGTTTG
AATGAGTGACTGAAGCATACACAGTGTTGTTCGTTGGAGACACTGAAACATACTCTAGGTTCCTTGCGGA
CTCTGCTGTTAACATAGGAAGGCACAGTCAATGGCACAAGGACTCTGGGACTTCTCTCCCAGGACTTCTC
CCTCCCCAGAGCACACTGTGTCCCCAGATAGGCAGGTGTTTGAAGCATCTCCTTTCCTGAGGGATCATTC
GTTCTTGACAGTCTTTGGAGCTCTGGGTGAACCTTCTCAGTCATGTGGTCTATTTCTGACCACATCTCTT
GGGGTAGAAGGTGGTGTTGAGGTCCCCTAAAGCTTCAGAGTCTCCCTCAGGCTTCACATGTGGGTCAGGA
AGCTCCTGGGACCAAATAGCCCTGCCTATGGAAGGGCTAAAGACACCTCATTGGCAAACATAATGGAGCC
AGTTATTTCACATTTGGGATATTATTAAGCTTTTCAGAGGTCTCTACAGCGGATTTGATTATTTTGGAGA
TGAGGAACTGGAGGCTCAGAAAACTTAACTGACTTGTGCAAAGCCATACAGACAGTGATGAAACAGCAAC
TCAAATGCACGTCTTCTGACTTCAAACCTTATGCCTTTTCCTCTGCAAGTGATGTCATGCATCACTCATG
CATGAAATGAGACCCAAAGCCAATCTGAGTCCAGAGCCTGTGTTTGTGTTTCTATATCATGTTTTCTCTT
TCCACTGTGTCTATCCATTGCCCAGACCCTGGCTGAACAGTAATGATGCAGTCAGACAGTTTGGTTTTGT
GCCTTGGATGCTCTAATCCTGCCTGTGCCCTGGACTTGCTGGGTGACAAGGGATGATCCCTTTCACTGGG
ACTTAGTTTCTCCATCAGCAGGGTGGTGAATGAACCTGATATCACCAAGAGAAACTGTGTGAGTGACTGG
TTCACATGCCTATGCCTGTGAACCATGTAGGACCCATGATTACAGATCATCTCCCCTCACAGCATGTGGT
CTGAGTAATGACATTCTGACTCCTTCCTCTGTCATTATCCAGCCCTCTGCCATCCCCCTCTCTCTTCCAT
TTGGCTCTTCCCATCTGCTTTATGATGGAGAGTTAAGAGTCTGAATGCTCACCGGGGCCCTGTGTTCGCT
GAGTAGACAAAGATAGGGAATCTGAAAAATAAAACCAGAAAATTGAAATGTGTGACAGCAGTGGGAGAGG
CATTTCACCCCTAACCCCGTGAGTGTTGGGATGTGGTGGGAGGGGACCCAAAAGGAAGGGCAAGCAGCCC
TGAGACAGGGTCCCACTTTTCCCAGTAGGACATTTCTCTCAGGATATTAGCAGGTGCAAGATCACACCCA
GGGATTATCTCAGTGGACTAGCTGAGCCAGGGTTTGCAGCCTCCCTCCCTCCTCCTGTCTTCCACAAGAG
ATCCTTGGGAATCAGAGGCCCCAAACTCTCAATCACTGGAACCTTGGAGAAGAGACAAGTAGGAAGAAAG
GAAACCTGCCTCTTCTTTTCCTCAAAACAAGTAACAGCAGTATGATGAAACCGAAGACTATGCATATCCC
AGAAACCATAAACAGAATCATTTTGGTATCTGTATATTGAATTTTAACATCTGAAAAGAGAAAAAAGAAA
TGACATTTGAGACACATCAAGTGAGGCCCACTGTTCTTGGAGCCTCCGTGGAGCCTCTTCTAGGCCATCT
TTGGGGACTAGGTAAGTTTGTCTATAGCCGGAGGCTCTGGGGTGGGAGTCCTATGTGGCAGGCAGGGGAG
GGTGGGGCCCAGTGGAGTTAGGGAGAGAAAGCAATCCTACATTCCCAGGCCTTTGATTTTGGGTTCTGAG
TAGGTTGGACGAGGGGTTGGGGAATGGAGAGGAAGGAAGGAGAGTCCTCTGGGAGTACTGAGAGATGCAG
AGCTCCAGAGGGCATCTGTCCCCTCCCAGCAGCATTTTCTGCCTCCCACTGGGCCACTGTATTGGAAATT
ACGTAGGATGTGAGGACGCGTTAAACCCCATAGCTGCTCAAGGCTCTCAGACCTGAGGCAGGCTGTTACC
TTCGCAAAGCTTCTGGGCAGAGACAGAGAAGGATAAATTACTGACAGCATTCTCTGCTATGCAGGTGTAG
TCCTGTTCACTGGAAATCCTGGGGTCCCAGGAGACAGTGAGGTTTGGCTGACTTGAAAGTGTGTTTCCCA
AGGCCTCCCATCTGAATGAGACATTGTCATCTGCATCCTCCACAGAGCAAGTCAGATGGAGCTCACAGGT
CATATTCTGAAATAGCTGACTGTGATTGGTAACTTGTATGTTCCTCAGTTGTCCTGTTTGCAGAAAAAAA
AAAGATCCAGATTAAGGACAAATGTCTTGGCTCAACCCCCTGTGAAAAATATCCTTCACCTCAATGTTTT
GTATTTCACCTTTGCTGTGTGTTATGGTCTGTAGACTCTGTAAATGACTCTGCTTATATTGCCTAATTGA
TGGTAGCAAGGTCTGGGATGACCAAATGATGCGGGACATCAGTATGGGGCAGGATAGTCAGCAGAAGAAG
TGGGAAGGGAGAGACTGAGGTTTCCATCAACTAGCTGGGTAGTTTTGGGGTGGTTATTTTATATTTCTGG
TCTCCAGTTTATCCCTGGGTTCCCTTCTAGTCCTTGCACTCTGCCCCTGTGTAAAGACAATTTGGAGACC
AAGCCAAGAACTCTGAGGGCAACTCAGTGATGTGAGAAGCCAAGAGACCAGGTGGAAGAGTCCTGTTTCC
TCTGCTATCAGAATTACCTAATTGGGGTGGAAGATGGAAGCATCACTTCCTTGGGGAATTTGAATCTATG
GGGATCCTGGTTCCTATTGTATCTAAAGCTGGCTCCAATAGTGAGAAAGAGACTCAGATGTAGAAGGTCA
GCAAGACAGAAAGGAAAATGCTGAGAACCAAAGAAGTGGGGAAGGAAGAAGTGAATAAGGTGAGAAAGCA
AGCAAGCAATTCTGGGGAGCAAAGAAGTGCGGCGTATCTAGGCATGTGAGATGACATGTGATGTAGGTAT
TTCTGAGAGCAAAGACCAGGAAATATTGCCTAGTAAGATGTAACTGTGAACCAATGGGAACATGGGAGCA
AGACAGAAAAGGCCACTGACTTAGCCTTGGCCTGAGGTTTGAAGTAAAGATGACCCAACCAGGAAGAGAA
TGACTCCAATTCTCTGATTAGAAGAGACCGAGTAGTACTTTGAGCTTAGTTGAGTAGGAGTTGTGGAGTA
TCTGTACTGAAATATTGCCAGAACAGAGTATTCATGTATGGGAAAAGTGTTGGATTTGGAGTCAAGACCT
GAATTTTGTAATTTACTGGCTACATGACCACGGACAAATTATTGCTATATCCAAGCCTCAGTTTCCTTAT
CTGTAAGACCAGGTAATAATACCCACTTCTCAGGTAATTTTGAGGAATAAATGAGACAGTGCCTAGTACA
GGGATGGCAAATATTTGGCATGAAAATCACATCTCCCTCATCCAGTGTTGATGGCTGAACTGAAAAAAAA
ATCCATCTTGTTACCTTTTTCCACTTAATGAATATGTAAGGACATTTCCACAGGTATATAAGTGTGTAAG
TATATCTCAAACTTGGTATAGTCTAAAGGACTCCCGTTTTTCTCTCCCAAACCTTCTCAACCTGCAGTTT
TACCCATCTGACTTGTTGACAACTGCATCCTTCCTATCACTGAGGCCAAAACCTCTGGAGTTATCGCTGA
TTCATATCTTCATCTCATACTCCCACATCAGGAAATCCTGGTGGCTTTACCTTCAACATATGTCCAAAAT
GTAACCACTTCTCACCATCTCCACTGCTATCACCCTGATCCAAGCTAGCATCAACTCTTGTTTGGACTAT
TGCAATGGTCTCCTAATTGGCCCATTGGCTTCTACCCTTCCCCCTTGAACTCTACTCTCAACAGATCAGC
CAAAGGAATCCTTTAGACAAGTAAGTCAAATCATATTACTTGTTTGCAAAACCTTCTGATGGTTTTCAGT
GTCACTGAGAGTAGATGCCAAAGTCTTTGTGATGGCTCTCAGTCCTTTTGCGATGTGGCCCCTGTTTCCT
TTCTGGCCTCATTTTCTATTACCTTCCCCTTACTCTGCTCCTGGACGTTTGGCCTCCTTGGTGTTTCTTG
AGTAGTCTAGGCACAGGGGATCTTGCTATCTATGCGGATGGCGTGTCTTCCAGTTATCTGCGTGGCACAC
TTCCTCACTTCCAACAGGTCTTGGCTCAAATGTCATCTTTTCAATGAAGCCTGTTCTGATCACTTCTTTT
AAAATTGTCCCCTGCTCCCTGGCACTCTTGATGCTTCTTATGCTGTTCTAATCTCTCCTTTGTTCATACC
ATTCAGGGCTTTCTTACATGCTGTATCACTTGTTTATATGTTATGTGAATTGCTTGTTACCTTCCTCTAC
TTCCCTTCCAGAATGTCTGCTCCATGAGGACAGTGATCTTTGTCTGTTTTGCTCACTGATGTATTCCAGG
TGCCTATAACAGTGCCTTGGACGTTATCCATGTCTAACAAATATTGTTGACTCAATTAATAAACCTATCA
TGGCTTCAAGATTTTCTTAACACTGAACTCTAGGCAGTTGTATTAGTTTGTTTTCACGATACTATAAAGA
TACTACTCAAGACTAGGTACTTTATAAATGAAAGAGGTTTAATTGACTCACAGTTCTACATGGCTGGGGA
GGCCTCAGGAAACTTACAATCATGACGGAAGGGCAAGGGGAAGCAAGTCACGTCTTGCATGGCAGCAGGA
GAGAGAGAGAAAGGGCAAGGAAGTGCCACGCTTAATACCATCAGCTTTCATGAGAGCTCACTATCATGAG
AACAGCATGGGGGAAACCTCCCACATGATCAAATCACCACCCACCAGGTCCCTCCCTTGACATGTAGGGA
TTACAATTCGAGATGAGATTTGGGTGGGGACACAGAGCCAAACCATGTTAGCAGTCACTCCCAATTAATT
GGTATTGGCCCATAAAATCAAATCTTTGCCATTCATATCCTGGCACATACCAAGAGATTGATCAATGTTA
AAAATCAAACCTATATAACTTATACCTTGAAATTCCTTTGCACTATTGTAAAACTACCTGGTGTAGCTTA
CACAGTTCTCTGTGTATGTGACTTTGAAGGAGATGGCACTCTAAAAAGCCCTGAAAGAGATCAGCATTGA
GCCTCAAGAGGGTGGCTGTCACAAGATAAGTCATACCTGGTCTTCTCAACAATGTTAGAGGAACATTATC
TCAGCAAATGTGATGAAGCCTGGTACCCATTTCAGGCTTTCCATTGGATGAGTCTCTCTTCTCTCCAGTG
TCCTACACTGCCTTGATAATTACTGGTCACCCAGGGTGATTCTGCCTGTAGTGGGTTGAATAATGACCTC
AGAAAAGATCTGTCTGCGCCCTAATTCCCAGAATCTGAATATTACCTTATTGGAAAAAAAGGGTCTTTGC
AGATGGAATTATGTTATATGACATTATCCAGTATAACCTGGATAGTCCCCAAACCCAATGACAAATGTTC
CCATAAGAGAAAAGCAAAAGGATGTTTGAGACAGACAGAAAAGAAGGAGGCAACCTGACTATGGAGGTAG
AGATTGGTGTGATGCAGCCACAAGCCAAAGAAAACCAAGGAGTGTTGACAGCAACCAGAAGCTGGGAGAG
GCAAAGAGCAGATTGCCCGCTACAGCCTCCAGAGGGAGCACAGCCCTGCCCACACTGTGATTTTGGACTT
CTGGCCTCCAGAACTGTGAGAGAATATGAATTTCTGTTACGCCACCTACTTTATGGTATTTCTATTTCAG
CAGCCTCAGGAAAGTAATACATTGCCCCAGGGTGATTTTTCCTTTTTAGTTAGAATCGCTTGTATAGAAG
TTTTCCAGACATCACCTCTTTCCCATTACATTTACCTGTTTGGTGTTCTATTCTTCAAGAACATGATTTT
GACTAATCTAACACGATAAACCTACCAGATATTCAGGGGATACTAAAAGTTAACATGTAATCTGTCTGTG
GAGACCTTTTATTTTAACAGTGCTTTTTTGAGTACCATGTCTTAACCCAAAGGACTCTGAGTGAATTTTA
GACACTACAGGCCCTCAAGTGGATAAAAATTACAGAATTTCCGTGGCCTTTAATGTTTTCTGGTCTGATT
GCCAATTTAATGCTTGAATCTCCTGCTAAGTGATTATTCTAAAGCCATTAATGGCATCTCTGAATATCAC
TGATTGCTAGAGAGGTATTTTTCTGATATTGACTCATAAGAAATCTCATTATAGTTTCCATAATTTTATG
TTGATAACATTTTCATTCTTTTTAATCTTGGGAAGGCAGATTGTTGACTGGTGATTAATATGAGCCATCG
GGGGAAAATATTGTTAAAAATTAAATAACCTTGACAGAAAGGATGTTTCTCATTATCAGCCTATCTTTGC
AGATAACTTTCTAGGTAGACCACTGTTCTGTACACTGACCACTCTACTGGGTCAGACTAGCCTTTGTGAA
AAGGGAGGTGTCGTGGCAGGTAGTTATGTGGGAAGTGCTACCATTACTATCTCTGTGACTTGTAGGCAAA
TCACTGTGACTGAGGCTGTGCCTCAAGGGTATAAGGTCTGTACCTACCTCATGGAGTCTTTGTGAGAATT
ACATGGCAAATACATGTAGTGCACAAGGCAACACTATCATAAATATTTGACTTCCATTACTTCTGCTACA
TTTCTGGTTGAAGAAGACCATTTTATCGGAGTGAAGTAATTCTGGGCTGGGACACAAGACTTAGGCTCTG
TCTTCAGCTCTGTCATTAACTGGCTTTGCAGTGTCATTGTGTTGACACTGACTCAATGACTCCAAATGCC
ATATTCTTTACCACTAGGCGACAGTGCACATTTGAAGTCACATAGGATTGGAATACATGTATATTTTTCA
GTCCATATGGAATTAAACCCCATATTTTGACTTACTTAATATCCTCAGAGTGTAACTGGACAGCTTTGCA
GAGGTCTTTGTGGATATCTGGGCTCTGTAAGAGCCTGTGTCTTCCATCTTCAGGTTGCTGAGTTGCAGGG
AGTAGGACTGGGTGAAGTTCAGTCGCTTTCCCTGTTTCGGATTAGTCACGTGGATTTCTGGACTTTTGGT
TTCATGGGGTACTATGAAGGCAAGAGATGTTTCATTGAAAAGCCAAGTGATGAAGTTGACCTTCTCTCCT
GCAGGAAACTCCAGGGGAAGAGTTACTGACTCCCCCAGAATCCCGTTCACCATCAATGGGGTTAAGCTGC
TTTGTGAAACTACATTCCCTGTAAACACAGAAGGAAAGGTTTTAAAAATGTTCCTGACCATCTCCCTGCC
AAGTCCTGCACCCTTTCACCTAACGCTGCCAGTCTGTTAGAGCTCTCTGATACCAAAACTCAGAGATATG
ACAGAGTAGGAAAGGGTAGGAGATGTTTCTAAATGAATAATCACAGTCCCAGAGCTTCACCTCCAGCAAA
ATGTCAGCCACTCTTGGTTAGTAGGCAGCTAGTCTAGATGAAACCGGCCCAGTCCACGCTGGGTCCTACA
CTGGCTGGTCACTCCTAGGTCATAACTATACTTTGTGATCCTAGCCTCTGAAGTCCTTGGACATTAGGTT
GAGGGGGACAGGAAACTATAGACTCCAAAAACTGCAAGTCTTTGCTAATAAAGCATAATTAAAGCCTGAT
ATTTACTGATTACTTACTGTGTGTCCAACATAGTAGGCTTGTGCAACTTAGAAGGCTGGTAACAGGGACT
AATATCAGGGATTTATAGGATAGTCAGTTCTTCTTATATATTATTTCATTGACGCTGACTACAGTCTGTG
AGGCAGGCAGGATGGATATTATTACTTCCATTTATAGATAAAGGAACTGAGCTACAGAAAAGTTAACTAA
TTTTCCCAGGGTTGCACAGCTAAAGAATAGCAGAGTCAGGATTCAAACCCAGGTCTTCTGACTCCAGTGA
CTTTGTGCTGTCTTCATGATACCAGAAGATTTTTTTTTAATTCTCTCAGAAAGATTATAGTTTAGTTATT
GAGGAGACAAAATGGATACATATAGAAATAATAAATATAATTTCAAAGTAACACATGATGGCCACATTCT
TGTGAACTTATTCAGAACTATCAATGTTTAAGCAAAAACGGTGAAATGGTCACAATGATTCTTAAAGAAG
ATGCTTCCTTAGCATCCTTTCCCAAATTCTTAGCAATTATTACACTATTTTGTAGTTTTGTTCACCTGTT
TGTCTAACTGACCACGCCTTAATTAGCCTTGCATGTCAGTACTCAGCACCATGTCTGACACATAGTAGAG
TCTGTGGAAATGTTCTAGTGGGTCAATGAATGAATAACTATAACAATTACCTCAACCTTCTCAGGATCTC
TTGCTTCTTTTTCTTAAAAATTTCAACTTTTATTTTAGATATGGGGGTACATGTGCAGATTTGTTACATG
GGTATATCACACCCAGATAGTGGACATAATAACTAATAGGTAGTTATTCAACCCATTACCTGTTCCCTTC
CTTCCCCCTCTAGTAGTCCACAGCGTCTATTAATCCCATATTTATGTCCATGTGTGCTCAGTGTTTAGCT
CCCACTTATAAGTGAGAGCATGTAGTATTTGGTTTTCTGTTCCTGTGTTGGTGTGCTAGGATTATGGCCT
CCAGCTCCACCCGTGTTACTGCAAAAGACATGATTTAATTCTTTTTTATGGCTGGTTAGTATTCCATGGT
GTATATATACCAAATTTTCTTTATCCAATCCATCATTGATTGGAACCTAGGTTGATTCTGTGTCTTTGCT
ATTATGAATAGCATAGTATGAACATACAAGTGCATGTGTCTTTTTGGTATAATGATCTATTTTCCTTTGG
CTATATACCCAGTAATGGGATTGCTGGGTTGAATGGTAGCTCAGTTTTAAGTTTTTTGAAAAATCTCCAA
ACTGCTTTCCACAGTGAAAATTTATATTTCCCAATAACAGTGTATAACTGTTTCCTTTTCTCTGCAACCT
CACCAAGTGGGACCTAGCACCTGTTTTTTTTTTATTTTTTGACTTTTAATAATAGACATTCTGAAAGAAT
GAAGGGTCCAGTTTCAATCTTCTGCATATGGCTATACAAAAATACAAAAAAGTGTATTAGTGTATTCTGA
ATTTTCTGTTCTCTTCCAGCTGTCATTCTGACAGAATGGCTATTATTAAAAAGTCAAAAAAGTGTTATTT
GTCCATTTTCACACTGCTGATAAAGACATACTCAAGACTAGTAATTTATAAAGGAAAGATGTTTAATTGA
CTCACAGTTCCCCATGGCTGGGGAGGCCATGGCACTCACAAGCATGGTGGAAGGTGAAGGAGGAGCAAAG
TCACGTCTTACATGGTGGCAGGCAAAGAGAACATGTGCAGGGGAACTCCCCTTTATAAAACCATCAGAAC
TCATGAGACTTATTCACTATCATGAGAATAGCACAGGAAAGACCTACCCCCAGATTCAATTACCTCCTAC
CAGGTCCCTCCCATGACATGTGGGAATAATGGGAGCTCTACAGTTCAAGATGAGATTTGGGTGGGGACAC
AATCAAACCATATCAAAAACCAAACCAGCATCTATTGTGTTCTTTTTTTTGACTTTTTAATAATAGCCAT
TCTGACTGGTGTGAGATGGTATTTCATTGTGGTTTTGATTTGGATTTCTCTGATGATTACTGATGCTGAG
CATTTTTTCATGTTTGCTGAGTGCTTGTATATCTTCATTTAAGAAGTGCCTGTTCATGTCCTTTGCCCAT
TTTTTAATGGGGTTATTCGTCTTTTTGCTTATTGGTTTAAGCTCCTTATAGATTCTGGATATTAGACCTT
ATGTTGGGTACATAGTTTGCAAATATTTTCTCTCATTCTGTAAGATGTCTGTTTACGGTAATGATAGTTT
CTTTTGCTGTGCAGAAGCTCTATAGTTTACTTAGGTTCCACTTGTCAATTTTCGTTTTTGTTGCAATTGC
TTTTGGGGACCTAGCCAAAAATTCTTTGCCAAGGCCAGTGTCAAGAAGGGTATTTCCTATTTTTTTCTAG
GATTTTTATAGCTTGAGGTTTTACATTTAAATATTTGATCCATCTTGAGTTAATTTTCGTATATGGTTAA
AGGTAAGGGTCCAGTTTCAATCTTCTGCATATGGCTAGCCAGTTATCCAGCACCATTTATTGAACAGGGA
GTCCTTTCCCCATTGCTCGCTTTTGTTGGCCTTGTCAAAAATCAGATGGTTGTAAGGGTGTGGCTTTATT
TCTGAGTTTTTTGTTCTCTTCCAGTTGTCTATGTGTCTGTTTGTGTAACGGTACCATGCTGTTTTGGTTA
CTATAGTCTTATGGTATGGTTCAAAGTCAGATAGTGTGATGTCTCTGGATTTTTTGTTTTTGCTTAGAAT
TGCTTTGACTATTTGGGCTCTTTTTTTGGTTCCATATGAATTTTAGAATGGTTTTTCTAATTCTGTGAAG
AATGACATTGGTAGTTTGATAGGAATAGCACTGAATCTAGAAATTGCTTTGTGTGGTATGGCCATTTTAA
CGATGTTGATTCTTCCAATCCATGAGCATGGAAAGTTGTCATTTCTGAGGGTTTCTTATTTCTTATAGGA
GGAGCTGAATAGGGAAGGAAATGTCTCTTGGAGTCCTAGTGCTCAGCTCCTGGGTGAGCTTGCACTTCCT
CTCTCTTTCATGAATTGTCATATGGGTTCCAGGCACATGAACATTGCTGTCATCAACATCTTTCCCATCA
GCATTTTAACACACTGTTATTTGTCATCTTTATTCCTCTTTCCTCTGAATCACATGGGTGAATACCACAA
GCAACATTTTGAGCAGAATGTCCAGATACCAGAGAATACAAATATATGATTCTATTTATTTAAAGTTGAT
AAACAGACAAATCTATGCTGTCAGAAGTCAAGAGAGTGGTTACCTTTGAGGAGGGAGAGGTGGTGAATAG
GAGGGAGTATAAAGGAAGGATCCTGGAATACTGATAATGTCCTATCTCTAGATCTGTATTTGGCTACACA
GATTTGTTCATTTTATGATAATTCATTGAGCTGACATTTAAGATTCGTATAGTTTTTCTCTTTGTATTTC
AGTTTAAAAAGTTAAAACAGTAACAAAAGCAGAGCAAAACAAAATCATGTCTATGGTCTATAAGGACCAA
AATGATCTGGCCATTTCTCTTTCTTTGACCTAATTCCTATATTCTCCCCCTTGTTCACTTTGCTCCAGCC
CCCTTGGCTATTCCTTGAGCAGGCCAGGGCTTTTGCATTTGCAATCCTTTCTGTCTGGAATGTACTTTCT
CCAAGTATCCATGCAGCTCACTCTTTTGCCTCCATAAAGTCATTAATGCAAACATTCCTGCTCAGAGAAT
TTAAAGAAGTGTGACCACTCTTTTTGCACCATCAGCCCCCATCCACCCTTGCACATCCAGCTGCCTTTGG
ATTTACCATCTAGTACTTACCATCTAGTATACTTTATAATTTAAATATTTGTTTTTGTTTATTTTCTCAC
CTCTCCACTAGAATGTAATCTCCATGGAGACAAAGATTTTTGTCTGTTTTGTCTACTATTGTGAACATTC
TTGAACAGCACCTGGCACATAGTAAGCATCCCATGAATATTTACTGAGTGAATGGACATATCTCCATCCC
TTCTCTTGGAGGTTTTCTGTCTAGAATGTTAAAGCTCAGTTCCTTTTGGTAGGGAGTCTGGGCTTACTCA
GTGGCCTAAGGACTCACCAGGAGCTGTTCTTCCCTTGCCTGGAACGCTTGTTTAAGTTCCATTGATTTTA
TAGATTGAAATAATTAGTTTATGTAACAAGATTTTATCTATGGCTATTTATGCTGCTTACAAGAAGAAAG
TCAAGGCTAAGGCAGAGTGGTAGCCTGTCTAGGCATTAAAGGAGTGCCCCAAAACAGAGCCAATCTGCAA
AGACAAGCACAGAAATTTATTTATTTGTTTGTTTGTTTATTCATTCTGGTGTTCAAATATTCTAATATTT
GCTAACTTCCATGCTAATTCAATTAGTAAAACCTTAGGAACCATGGCATATTTATTAGGTCTGTTTTATG
TACCAGTTTCTAGACTGGAAACTGGGAATATAAGATACTGTCAGTCCTCTGGGTCCATCATCTGATAGAG
GAGCCTGACAGGTAAATGAGTAGTTAGTTCTGATGTGGTGGGTTGGGCATTGAGCTAGTGTAAGGCTTGC
CTCTGCATTGCCCTCGTATCACTATTGCAGTTATACATGCAATTGCAAGCAGTTCTTTCTCTTTGTTATA
ATTACAAGATTATTTTCTTTTCTTTTCCATAATCTTGAGGTCAGGGATTCTGATTATTATTTCTATATTC
CTAGAACTTAGCACACAATTTCTAGCTCAATAAATGTTGAATTGTTAGAGATATGTGCTCCATGGGAGCA
AAAATTTAGAGAATCATGAACTGGGAAGAGTTGGGAGTTGTCAGGGAACAGTTCACAGGAGATGACACTG
TAGCAAAGTCTTGAATAAAAGCTATGAGTTCTCCATTACTTAATTATTTGTAATTCTTCCAATAATGCCT
TGCTTTTTTTTTTTTTTTGCACTGCTTTTCCCTCTGCTTAAAATGCCTTTCTTCATCTTTCCTACATGGT
AAGCTCCTATTTATCCTTCAAGGATGAGCTAAAATATCTGTTTGCCTCTTATATTTATGGGGGTTTTGCA
TTGGTACATGGGGAAGGGGAGAAAGGAGTTTGTGGTGAAGCAAAGGGAGAAGGAGCACAGGATGGATGAG
ATGGTAGGAATAGTTCCCCACAGACCCAAAACCAAACCAAAGCAAAACTAGATTTGAGACAATATGCTTA
GGGACAGTGAAGGTCAGATGCTACTGAAAATGTTTAAAAGACCCTGCATGAGACTTTGGACAGGAGCAGA
GCTGCTTCAGGGCCAAGGTGTTGTGGTGTGGCCCAGAGGGCACATGGAGGTCCTTTTCTCTGCTCTGCCA
GGAATCAACACTGATGCTTTGGGAGCATCCGGGACCAGCACCCTTGGCATGGACATTGATGTTCTTGGAA
TAAGCAGGGCATCTAAATGGCTCTGCTGGCATCCTGTGTGGGGGACTAGAACCAGAAAAGGAGATTAAGA
ATGGGAAAGATGCCTCATGTTGGCTACAACTCGTAGGCTGCTTTGGGGACTCATGGGAAGCTTTCCTTTG
AGACTCTCATAAGTCACTGGGGAACTCCTTGCAACATGAAGGTGATGCTGAGGTCTTGCCCATCCACTGG
TGAGGATGTCAAGACAGCAGACATTTGGGGTACATTTGTTTACAAGTTTCATCTACTGTATGATGTGTTT
TGGGGAACTCAAATAATATCTTAGTCAGCATTGTATTTCCCCATAACCTGGTCCAGGGAACTCAGTGAAT
GTTAAGTAGATTGGAATTAGAATAGAGAAGTTTTTAAGGGTTACCTGATTAGTGGAGGGTTAGTTTGGAA
GGTATTAAAAAACATGAAGTATTTTTGAAAATTGGCAAAGTATAAAGAGAGCAGTGTCTTAGGAAAGAGA
GGAGAGAGGTAGAACTAAGCAGATTCTGAAAAAGAGAGAAAAGTCAAGGAACTTTGGGTTTCTAACCTGA
GGGACTAGCTTAGGCCCATCTATAGCTAACAGGAATATAGCAAGCTGTGTTAGCTCCACAGGAGGCAAAT
GCAGTATGAAAGAGAGTAGGGGCTGATTTCTCAAGAGAATTTAAAGAGAAGGGAGGAGAAACATAGTCAG
GATATTGAGAAGGTAGGACAAATGGAAGTTACTCTTTAGGTAACAGAGTCCTGAGCAAATTTGGAGCAAA
GGGAAGCAGCTGGGAGAAAAAGAAAAAACTTAAGATATGGTGAAAGGGAGTATTCAAAACGGTGTCATTT
CTGAGGAGGAAGCCAGGGTGGGCTTAGGAGCATAAGTGAAGAGGTTAGTCTTGGGTAGACGTGGTTCTCC
TTTTCTTTTGAGACTGAAAAGAATAAGGTTAAAGATCTCAAAAGATTTAGAGGGTAAAGGGGAAGAAGTT
GGAATATTTCGCTTATGTTTTTCTCAAAGTTGTTCTAAGAGAAGTAGATCTCATAGAATCTAGAGGAAGA
CGGATGAGACATGTAAAAGCTGCTATGAGGAATTTGTTAGGAAACTGACAAGTCATCAATAAATGAGTGT
GGAAGCAGTGAGGAGGAATTGGCCAAGCTTGGTTGACACGCACCATTCATGGAGTCCATCCAGTTTTGCA
TTGGCTGGTGCGAAAGTGATTGCGGATTTTGCCATTACCTTCAATGGGAAAATCCGCAATCACTTTTGCA
CCACACTAATAACTTTCTCCAATGATTATAGCACTTGTAGCCCAGGAACAGGGAAAGAAGGTGCTGGGGA
TCACCTAATATTAGCAATAGGCATAGTATAGGTAGGTGTGGCATCAAAGGGGAGAGGGATTTCAGGGGAA
TGGTGACTACTTTGTTGAAATTGCTGGCCTAAAGTCTGAGGGTCAGTGACATTAGTCAAAATGGCACAAT
AAATAACTGCAAGGGTCCATCCCTCCACAAAAAACATGCACACTCATGCGAACACACACAGAGTGAGCAA
ACATTGTCAGAATCAACTTTGTCAGAACTGTAGAAACTAGTCAAAGGTTTATAGCAACCAAACAAATGAT
GGGTCAAAAAAAGAGGCAACTTAAAAATGCTAGGAGTTCTAGTCTGGCCAACATGGTGAAACCCTGTCTC
TACTGAAAATACAAAAATATCAGCCAGGCAGAGTGGAACATGCCTGTAGTCCCAGCTGGGGAGGATTGTT
TAAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCATGCCATTGCACTCCAGCCTGGGTGACAGAGTG
AGACTCTATCTCAAAAAAAAAAAAAAAAAGCAAAAGAAAAAAAGGAGTTAAAAAAAGCCAAATACATAGA
AACAAAGTATAAAGCAGTGGTTATCAGAGGTGGAGAGAGGGAACAGAGAGGAAATGGGGAGATGTAGGTC
ACAGGGTACAAAGTTGCAGATATGTAGGGTAAATAAGTCTAGGAATCTAATATACAACATGAAGGCTATA
CTTATATTATTGTATTGTATACCGAACATTTGCTCAGAGTAGATTTTAGATACTCTTACCATACTTGCAC
AAAAAGGGTAACAGTGCAAGATAATGAATATGTTAATTTGCATGACTAGGGTAACCATTTCACTGCATAT
ATCAAAATGTCATGTTGTACAGCTTAGATATACACAATTAAAAAAAAATCATTGGGGAGCTTTGCAGAAT
GTTTGATTGCCCTTTCCCCGATCTTTTTTCTCCAACTTGATAGCAGTCTTGAAGACAGCCGTCTACATTT
TCAGTAGGAGACCATGGTCACTGGTTCCAGCAGGCATAGAGCAGAACTGGTTCTGAAAGAATTGTATTTG
TCTGTTTTCAACTATCTGGATGCTCCCTAAAAAACTGAGGAAAAGCACTTGTCTTTGTCTCAACTACCTC
TCTTTCAGGTAGAAAATTAGCCATGCAGAGGACATTTCTCATAAACACTGAAAGGCAATGAATAACCCAT
CAATACCTGGGGCAAAACATTATAGTGGAGGCAAAAAATAGATATGTCGAATGCCTGGGAAGAAAAGCTG
GGGAGAAAGATTCTTAGAAGAATTCAGGCATTAAGAAAATGTCTGCTTATACCAGGGAATTTGGAAAGCC
ACATACATGCCTAGGGCAGGGTGCATACTTAGAAAAGTTCTGAGAAGACTCTAAGATTTTATCTATGGCT
GATAATTATGCTGGGTACAAGAAGAAAGTCAAGGCTAACGCAGAGTGGTAGCCTGTCTAGGCATTAAAGG
AGTGCCCCAAAACAGAGCCAATCTGCAAAGACAAGCACAGAATTTATTTATTTATTTGTTTGTTTATTCC
TTCTGGTGTTCAAAGAAATATCTGTCAAAACACTAGTTGACCATAAGCTAAAGAAAAAGACATTTTAGAG
ACTACATGTGACAAATAATATGTTTACAAAAATAGTTTAGAATAGTCACTAAAAAAACAAGAATTACAAC
CCAGAGCAAGGAACAAAACAAAATACTGAGGAAGGGGAAGAGTCTGATTTCCAGAGTTATCATATTATGG
TATTAAAAATATCTAGTTTCAACAAAAAATTATAAAGCATGTGAAGAACAAGAAAGTGTGACCCATTCAC
AGGTGAAATAAACAGAAATTGTCCCTAAGGAAGGACAGATACTGGATTTGCTAGACAAAGTCTTTAAGTC
AACTGTCTTTTTTTGAGACAGGGTCTCACTCTGTTGCCCAGATTGGAGTGCAGTGGTGTGATCTCAGCTC
ACTGCAACCTCTGCCTCCTGGGCTGAAGTCATCCTCCCACCTCAGCCTCCTGAGTAGCTGGTTCTACAGG
CACATGCCACCATCCCTGGCTAATTTTTAAAATATTTTGTAGAGATGCAGTTTCACTATGTTGCCCAGGC
TGGTTTGAACTCCTGGGCTCAAATGATTTACCTGCCTCGGCCCCCACAAAGTGCTGAGATTACAGGCATG
AGCCACCCTGCCTGGCCTCAACTATCTTAAATATGCTCAAAAAGCTAAAGGAAACAATGGACAAAGAACT
AAAGGAAATCAAGAAAAGGATATATAAAGAAAAGAGAATATTTTTAAAAGATAGAAATAATAACAAGGAG
CCAAGTAGAGATTCTGGAGCTGAAAAAATACAATAATTGAAATAAAAAATTCACTAGAGGCTTTCAACAG
AAGCTCTGTGTAGGCAGAAGTAAGAAATAGCTAATTCAAAGCTAGGTCAATTGAAATTATCCAGTTTGAG
GATCAGAAAAGAAAAGAGTGAAGAAAAATGTACAGTGCTTAAGAGATTTGTGGGACACCATCAAAAATAC
CAAAAAATAAGCATAATAGGAGTCCAAGGAGGAGCAGAGAGAGAGAAAAGGGCATAAATAATATTTGAAA
AAATAATGGCCCCAAACTTCCCAAACTTTATAGAAGACATGAATTTATACATCCAAGAAAGTCAATGAAC
TCCAAGAAGAATGATCACAAAGAGATCCATAACAAGACATATTATAATCAAACCAGAAAAATGAAAACAA
GGAGAGAGTCTCAAATGCAACAAGAGAAAGCAACTAGTCATGTACAAGTCATGCTCAATAAAATCAACAG
CCAATTTCTCAGAAGAATCCATGATTGCCAGGAGGCAGTGGGATGACATATTTAAGGTGCTGAAAGAAAA
AAAAACACCCATCAACCAAGAATTCTACATCTGAAAAAATTATCCTTCAAAAATGAAGGAGAAGTTAAGA
CATTTGCAGATAAACAAAAGCAGATAGAGTTTATTGCTAGTAGACTTGTACTGTAAGAAATACTAAAGGG
AATCTTTCAGGCTGAAATAAAATCACACTAGAAAGTAACTCAAATCCCTACCAAGAAACAAAGAATGAAG
GTAAATCTGACTGCATAGATTAATACAAAAGCCAGTATTCTTGCATTTTTGCTTTGCAACTTCTCCTTTT
TCCCACATGATTTAAAAGACAAATGAGTAAAACAATAATTATAAATCTGTTAATGAGCACACATGCACAA
AGATGTAGTTTGTTACAACAACGTAAAGGCAGCAGAATGAAACAACATTGGAGCACAGTGTTTGTATATT
ATTGAAGCTAAGGTAGTGTGAATTCAAAATAGCTTGTTATAAGTTGAAGAGGTTAAATGTAACACTGAGG
ATAACAATACAATAACTAAAAATACAGGAAAGGAAATGAGAAAGGAATCTAAACTTAAAAATATAAACTA
TACATGAAAGAATAGAATAGTGGAGGGACTGAGGGGAAAAGGTTTAAGACATACAGAAAAGAAATGGCAA
AATGCAAGAAGTAGGTCCTTACATATCAGTCATTACTTTAAATGTAAATGAATTGAACTCTTCAATTAAA
ATGCAGAGATAGGCAGAATGAATTGAAAAAACAGGATTCAACTATTTTCTACATACAGAGATTCACTTTA
GATTCAAAGGCACAAATACTTTTAGAAGAAGAAGATGGAAAATGATATTCCATGCAAGTAGTAACCAAAA
GAGAGTTACAGTAGCTATACTAATATTGGCAAATAGACTTTAAGTCAAAAATTATTAGTAGAGGCAAAAA
AGGACATTATACATTAATAAAAGGGTCAACCCTGCAAAAAGTTATAACAATTATAAACACATATGCACCA
AACAACAGCCCCAAAATATATAAAGCAAACAGTAACAAAATTCAAGGGAGAAATAGATAGTTCTACAGTA
ATAGTTGGAGACATCAATACCTCACTTGCAATAATGGTCAAAACAACTAGAGAGAAGATCAATAAGGAAA
TAGAGGACTTGGAAAACATTATAAACCAACAATACCTAACATATATATGAAAAACACTACATCCAAACAC
AACAAAATATACATTTTCCTCAAATGCACATAAGTCGTTCTCATAGGACAGACCATATATTAGGCCACAA
AAACAAGTCTCAATAAATTATAAAAGACTTAAATATATGATGTCTTCTATGACCATAAATGGAATAAAAC
TGGAAATCAAGAACAGAAGGAGAATTGGAAAATTCACAAATATGTCATAATTAACATAGTGTAAAATAAT
CAATGGATCAAAGAAGAAATAACAAGATGAATTAGGATATATCTTGACACCAAGTGAAAACAAAAACAAA
GCTTACCAAAACATGGGATGGAGCAAAAGTAGTGCTCAGAGGGATATTTTTATCCCTCTGAAAGAAAGAA
GGAAGACTAGGAATCCAACTTAAAAGGGATGTGAAGGACCTCTTCAAGGAGGACTACAAACCACTGCTCA
ACAAAATAAAATAGGACACAAACAAATGGAAGAATATTCCATGCTCATGGGTAGGAAGAATCAATATCAT
GAAAATGGCCATACTGCCCAAGGTAATTTGTAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTC
TTCATAGAATTGGAAAAATCTACTTTAAAGTTCATATGGAACCAAAAAAGAGCCCACATTGCCAAGACAA
TCCTAAGCAAAAAGAACAAAGCTAGAGGCATCTCACTACCTGACTTCAAAATATACTACAAGGCTACAGT
AACCAAAACAGCATGGTACTGGTACCAAAACATATATATAGATCAGTGGTACAGAACAGAGGCCTCAGAA
ATAGCACCACACATCTACAACCATCTGATCTTTGACAAACCTGATAAAAACAAGAAATGGAGAAAGGACT
CCCTATTTAATAAATGGTGCTGGGAAAACTGGCTAGCCATATGTAGAAAGCTGAAACTGGATCCCTTCCT
TACACCTTATACAGAATTTAATTCAAGATGGATTAAAGACTTAAATGTTAGACCTAAAACCATAAAAACT
GTAGAAGAAAACCTAGGCAATACCATTCAGGATATAGGTATGGGCAACGACTTCAATACTAAAACACCAA
AAGCAATGGCAACAAAAGCCAAAATAGACAAATGGGATCTAATTAAACTAAAGAGCTTCTGCACAGCAAA
AGAAACTACCATCAGAGTGAACAGACAACCTACATAATGGGAGAAAATTTTTGCAATCTACCCATCTGAC
CAAGCGCTAATATCTAGAATCTACAAAGAATTTAAACAAATTTACAAGAAAAAAAAAATCCCATCAAAAA
GTGGGCAAAGGATATGAAGACACTTCTCAAAAGAAGACATTTATGCAGCCAACAGACATATGAAAAAATG
CTCATCATCACTGGTCATCAGAGAAATGCAAACCAAAATCACAATGAGATACCATCTCACACCAGTTAGA
ATGGCTATCATTAAAAAGTCAGGAAACAACAGATGCTGGAGAGGATATGGAGAAACAGGAACACTTTTAC
AATGTTGGTGGGAGTGTAAATTAGTTCAACCATTGTGGAAGACAGTGTGGCAATTCCTAAAGGATCTAGA
ACTAGAAATACCATTTGACCCAGCCATCCCATTACTGGGTATAAACCCAAAGGATTATAAATCATGCTAC
TGTAAAGACACATGCACACGTATGTTTGTTGTGGCACTATTCACAATAGCAAAGATTTGGAACCAACCCA
AATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATATACCATAGAATACTATGCAGCCAT
AAAAAAGGAAGAGCTCTTGTCCTTTGTAGGGACATGGATGAAGCTGGAAACCATCATTCTCAGCAAACTG
TCACAAGGACAGAAAACCAAACACCACATGTTCTCATTCATAGGTGGGAATTGAACAATGAGAACACTTG
GACACAGGGTGGGGAACATCACACACTGGGGCCTGTCAGGGGGTGGGGAGCTGGGGGAGGGATAGCATTA
AGAGAAATACCTAATGTAAATGACGAGTTGATGGGTGCAGCAAACCAACATGGCACATATATACCTATGT
AACAAACTTGCACGATGTGCACATGTACCCTAGAACTTAAAGTATATTAAAAAAATAAAGAAGGAGGAAA
TTTACACTTTAAAAAACTAGACAAAGAAGAGCAAACTAAACCCAAAGCTATTAGAATGAAGCAAATCATA
AAAATTAGAGCAGAGATAAATAACATAGAGAATAGAAAAACAAGAGAAATAATCAATGAAACCAAAAGTT
GGTTCTTTGAAAAGATAAACAAAATTGACAAACCTTTAGCTAGATTGACAAAGAATAAAATAGAAAAGAT
TCAAATTACTAAAAGTAGACATAGAAGTGGAGACATTACTACAGATCTTATAGAAATAACAACTAAAAGG
ATTAAGAGAACACTATAAATAACTATATGCCAACAAATTGAATAACCTAGATGAAATAGATTTCTGGAAA
CACATAAAATACCAAGACTGACTTAAGAAGAAATAAAAAATTAAAGAGGACCTATAACAAGAAAAGAGAT
TGAATCAGTACTCAAAAACCTCCTGACAAAGAAAATCCAGATGGCTTCACTGGTAAATTCTACTAATTAT
TCAAAGAATAATTAGTTTCAATTATTCTCAAGCTCTTCCCAAAAATAGAAGAGGAGAAAAACACTTCCTA
AGTCATTTTACTAGGTCAGCATTACCCTGATACCAAAGCCAAAAATATCAGAAAAAAGAAAACTACAGAC
TGATATCCCTTATGAATATTGATGCAAAAACTTTCAACAGAATACTAACAAACTGAATCCAGCTCATATT
AAAGGGATTATACACCATGACCAAGTAGAATTTATCTCAGCAATGCAAAAGTGGTTCAATACATGAAAAC
CAATCAATGCAGTATATGATATTAACAGAATGAAGAAAAATAGACTAATGGCCATCTTAGTTGATGCAGA
AAAAACATTTGAAAAAAACCAGCACCTTTTAAATAAAAACACTTTAGAATCTAGAAATAGAAGGGAACTT
CCTCAGTCTGATAAAAGGCATTTATGAAAACCCACAGCTAACATTTTACTCAAGGATAAAAGACTAAAAG
CCTTTCAAATAACAGCATGAAAAGGCAACAGTGCCCAGTCTCACCACTTCTATTTAATATTGAACTGGAA
GTTCTAGCCAGAGCAATTAGGCAAGAAAAATAAATAAAATGCATCTCAATTGAAAAAGAATGTGTAAAAC
TATTCCTATTCACAGATAACATGATGTTGAAAATAGAAAATCCTAAAGAATCCACAAAAATGATCAGAGC
TAATAAATAAATTCAGCAAAGTTGCAAGATACAAAATCAATGTATAAAAATCAGTTCTGTTCCTACACAC
TAGCAATGAACAATCTGAAAAAGAAGTTAAGAAAAGCAGTTCCATGTACAGTAGCATTCAAAAGAACAAA
ATACCTGGCAATAATTTAACCAGAGAAGTTCAAGATAATACACTGAAAACTAAATAACATTTCTGAAAGA
AAGAAAATCTAAATAAATGGAAATACATCCTATGTTCATTAATTGGAAGATAATATTAATATGCCGATAC
CACCAAAAGCAATTTATAGAGTCAATGCAATCCTTATCAAAATGTTGATTTTTTTTCATAAATGGAAAAG
CTAATTCTCAAATTTATATGTGATTTCAAGATGCCCCAAGTAGCCAAAACAATATTGTAAAAGAAAAGCA
AAATTGGTGGACTCACACTTTCCAATTTCAAAACTGATACAGATATGGTAATCAAAACAGTGTGGTACTG
GCATAAAGATAAACTTATAGATGTCTATATGAAATTAAATTGAGAGTCCATAAATAAACCCAAACATTTA
TGGCCAGGTGATTTTTGACAAGAGTGCTAAGATCATTCAATAGGGAGAGAATGCTCTCTTTAACAAATGG
TGCTGGGACAACTGGATATCCACATTCAACAGAATGAAGTTGGGCCCCTTCCTCTCATTATATGCAAAAA
TTATCTCAAAATGTATCGATCACCTAAATATAAGAGCTAAAACTCTTAGAAGAAAACATAATGATAAATA
TTCATGATTTTTGATTTGGGAATGGATTCTGATATATGACACCAAAAGCATAAGTAAGAAAAGATAAAAT
GTGGGGAGGGGCCAAGATGACTAACTAGAAACAGCTGTGGTTGGAGGATCCCACTGAGAAGAACGAAAAC
AGTGAGTGAATCCTGCACCAGCAACTAAGGTATCCAGGCTCACTCATTGGGACTGACTAGGTGGTTGGCA
TGACCCACAGGGAGTGAGGAAAACAGGGTGGAACAACAGCCCACCTGGAAGCTGATGGGGCAAGGGGTGC
TCCCACCCCCAGCCAAGGGAAGTGGTGAGTGATTGTGCTACCCCACCCAGGAAACCATGCTTTTTCCATG
GATCTGTGCAACCCATGGACCAGGAGATCCCCTCGTGAGCCAACACCACAAGGGCCTTGGATCCCAAGCA
CAGAGCTGTGCAGATTCTCAGCTGCCACTTGGCTGGAGACCGTCTAAGACTACTGAGTTCTTGGGGGAAG
GGGCAGCAGCCATCACTGCAGCTTCTGTCTGCTGCTTTCCCCTGCCAGTGCCAGAGGGACTGGTGGTTTG
GAACCAGGAGGAATTCCCCATGGTGCAGCACAGCAGCTGTGGCAGACTGTGGCCAGACTGCATCTTTAGG
CTGGACCCAGACTCATCCCTCCTCACTGAATGGGACCTCCCTGTGGGAATTTCAGCAACTCCAGCCAAGG
GTTTATGGACAGAACCCTGATCTCCCTGGGATTGAGTCCCTGTGGGTACTGGGGCTGCGGACTCTGTGGA
TCATCAGACTTAGTCTTTTCCCCTGCTGGCTCTGAGGAATCTGGGCAGTCTGGATAAGTAGGATCCCCCC
CACCACAGCACATCCTTTCTGCCAAGGGACAGACAGAATGCTTCATTAAGTGGGTCCCTTATCTTGTGAC
TCCTGACTGGGTGAGACTCCCCAGCAGGGGTTACCAGACACTTTATACAGGAGCACTCCCACTGTCATCA
GTTTGGTGCCCCTCTTGGACGGAGCTCCCAGAGGAAGAAGCAGGCAGCCATCTTTGCGGTTCTGCAGCCT
CCACTGGTGACACCACCAGGGTGGGGAGGGACCCAGGTGAATAGGATCTGGAGTGGGCCCCCAGCAAACT
GCAGCAGTCTTGCAAAAGAGGGTCCTGTCTGCTAAAAGAAAAACAAACAGAAAGCAACAACAACAGCATC
AACAAAAAAGTCCCCACAAAAAGCCCATCCAAAGATCAGCAGACTCAAAGATCAAAGCTAGATAAACTCA
GGAAGATGAGAAAGAATCAATAAAAAATGCTGAAAACTCAAAAAGCCAGAGTGTCTCTTCTCCTCCAAAT
GATTGTAACACCTCTCCAGCAGGGCACACAACTGGGCTCAGGCTGAGAAGGATGAACTGACAGAAGTAGG
CTTCAGAAGGTGGGTAATAATGAACTTTGCCGAGCTAAAGGAGTATGTTCTAACTCAATGCAAAGAACCT
AAGAATCAGGATAAAACATTACAGGAGCTATTCATCAGAATAACCAGCTTAGAGAGGAACATAAATGACT
TGATGGAACTGAAAAACACAACATGAAAACATCACAATGCAATCATAAGTATCAATAGCCGAATAGACCA
AGTGGAGGAAAGAATTTAAGAGATTGAAGACTATCTTGCTGAAATAAAATAGGCAGACAAGATTAGAGAA
AAAGGAATGAAAAGGAACAAACAAAATCTCTGAGAATTATGGGATTATGTAAAGAGACCGAACCTACAAC
TGATTATGGTACCTGAAAGAGACAGGTGAATGAAACAAAGTTGGAAAACATACTTCACGATATCATCCAG
GAGACTTCCCCAACCTAGCAAGACAGGCCAACATTCAAACTCAAGAAATACAAAGAACCCAGTAAGATAC
TCCATGAGAGGATCAACCACAAGACACATAATTATTAGATTCTTCAAGGTCAAAATGAAGGAAAAAATGT
TAAGGGCAGCCAGAGAGAAAGGCCAAGTCACCTACAAAGGGAAGCCCATCAGAATAACATCAGGCCTCTC
AGCAGAAACTTTACAAGCCAGAAGAGATTGGGGGTCAATATTCAACATTCTTAAAGAAAAGAATTTTCAA
CCCAGAATCTCATATCTGGCCAAATGAAGCTTCATAAGCAAAGGAGAAATAAAATATTTTTCAGACAATC
AAATGCTGAGGGAATTCATCCACCACCAGGCTTGACTTGCAAGAGCTCCTGAAGGAAGCACTAAATATGG
AAAGGAAAAGCCATTATCAGCCACTACAAAACATACTGAAGTACACAATGAAGACCAATGAAACTGTGAA
GCAACTACATCAATAAGTCTGCAAAATAACTAGCTAGTATCATGATGACAGGATCAAATTCACACATAAC
AATACTAACTTTAAATATAAATGTGCTAAGTGCCCCATTTAAAAGACACAGAATGGCAAGCTGGGTAAAT
TGTGAAGACCCATTGGTGTGCTGTATTCAAGAGACTCATCTCACATGCAAACACACACATAGGTTCAAAA
TAAAGGGATAGAGGAAAATCTACCAGGCAAATGGAAACCAGAAAAAAGCAGGGATTGCAATCCTAGTTTC
TGACAAAATAGACTTTAAAGCAATAAAGACCAAAAAAGACAAAGAAAGGCATGGTAAAGGGTTCAATTCA
ACAAGAAGAACTAACTATCCTAAATATGTATGCACCCAATACAAAAGCAGATTCCTAAAATAAGCTCTTA
GAGACGTACAAGGAGATGTAGACTCCCACACAATAATAGCGGGAGACTTTAACATCCACTGTCAATATTA
GGCAGATCATTCAGACAGAAAATTAACAAAGATATTCAGGACTTGAACTCAGCTCTAGATCAAGTGGACC
TGATAGACCTCTACAAAACTCTCCATCCTACAACAACAGAATATTCATTCTATGCATTGCCACATGGAAC
TTACTCTAAAATTGATCACATAATTGGAAGTAAAACACTCCTCATCAAATACAAAAGAACTGAAATCACA
ACAAACAGTCTCTCAGACCACAGCATAATCAAATTAGAACTCAAGACAAAGAAACTCACTCAAAATCACA
TAGCTACATAGAAATTGAACAACCTGCTCCTGCATGACTCCTGGTTAAATAATGAAATTAAGGCAGAAAG
CAAGAAGTTCTTTGAAACCAATGAGAACAAAGAGACAATGTATCAGAATCTCTGGATGCAGCTAAAGCAG
CTGTTAAGAGGGAAATTTAGAGCACTAAATGCCCACATCAAAAACCTAGAAAGATCTCAAATTGAAATGC
TAACATTAAAACTAAAAGAACTGGAGAACCAAGAGCAAACAAACTCCAAAGCTGGCAGAAGACAAGAAAT
AACCAAGATCAAAGCAGAACTGAAGGAGATAGATAAAAGAAGAATGCTTCAAAAAAATCAAGGAGTCCAG
AATCTGGTTTTTTGAAAAACTAATAATATAGATAGACTGCTAGTTAGCTAGACTAACAAAGAAGAAAAGA
GAGAAGAATCAAATGGACACAATAAAAAATGTTAAAAGAGGATATCACTACTGACCCCACAGAAATAAAA
ACAATCATCAGAGAATACTATAAACACCTCTATGCACATAACCTAGAAAATCTAGAAGAAATGGATAAAT
TCCTGGACACATACACCCTCCCAAGACTGAACCAGGAGGAAGCTGAATCCCTGAATAGACCAATAACAAA
TTCTGAAATTGAGACAGTAATAAATAGTCTAAAAGAAAAAGCCCAGGACCAGAAGGATTTACAGCTGAAT
TCTACTAGAGGTACAAAGAGGACCTGGCACCATTTCTTCTGAAACTATTCCAAACAATTGAAAAGGAGGG
ACCCTTCCCTAATTCATTTTATGAGGCCAGTATCATCCTGATACCAAAACCTGGCAGAGATACAACAAAA
AAGAAAGCTTCAGGCCAATATCCTGATGAACACTGATGCAAAAATTCTCAATAAAATACTGGCAAACCAA
ATATAGCGGCACATCAAAAAGCTTATCCACCCTGATCGAGTTGGCTTTATTCCTGGGATGCAAGGCTGGT
TCAACATATGCAAATCAATAAATGTAATTCATCTCATAAACAGATCTAAAGACAAAAACCACAGATTATC
TTAATAGACACAGAAAAGGCCTTCTATAAAATTCAACATCCCTTCATGTTAAACACTCTCAATAAACCAG
GTATTGATGGAACATATCTTAAAACAATAAGAGACATTTATGACAAACCAACAACCAATATTATACTGAA
TGGGCAAAACTGGAAGCATTTCTTGTGAAAACCAGCATAAGACAAGGATGCCCTCTCTCACCACTCCTAT
TCAGCATAGTATTAGAAGTTCTGACCAGGGCAATCAGGCAAGAGAAAGAAATAAAGCATATTCACACAGG
AAGAGAGGAAGTCAAATTATCTTTGTTTGCAGATGACACGATCCTATATCTAGAAAACCCCATCATCTCA
GCCCAAAAGCTTCTTAAGCTCACATGCAACTTCAGCAAGATCTCAGGAAACAAAATCAATGCAGAAGTTA
CAAGCATTCTTATACAACACACACAGGCAAGCAGAGAACCAAATCATGAATGAACTCCCATTCACAATTG
TTACAAAGAGAATAAAATACTTAGGAATACAGCTAACAAAGGAAGTGAAGGAACCTCTTCAAAAAGAACT
ACAAACCACTGCTCAAGGAAACCAGAGAGGACACAAACAAATGGAAAAATATTCTGTGCTCATGGATAGG
AAGAATCAACATCATGAAAATGACCATACTGCCCGAAGTAATTAATAGATTCACTACTATTCCCATTAAA
CTATCATTGACATTTTTCACAAAATTAGAAAAAACTATTTTAAAATTTATATGGAACCAAAAAAGGGCTC
ATATAGCCAAGACAATCCTAAGCAAAAGGAACAAAGCTGGAGGCATCATGCTACTGGACTTCAAACAATA
CTATAAGGCAGCAATAACCAAAACAGCACGGTACATGGTACTGGTACAAAACAGACACATAGACCAATGG
AACAGAATAGAGAACCCATAAATAAGACTGCACATCTACCACTATCTGATCTTCAAAAAACGTGACAAAA
ACAAGCAATGGGGAAAGGATTCACTATTTAATAACTGGTGCTGGGAGAACTGGCTATCCATATGCAGAAA
ATTGAAACTGGACCCCTCCCTCACACCTTATACAAAAATTAACTCAAGATAGATTAAAGACTTAAATGTA
AAACTCAAAACTATGAAAACCCTAGAATACAATCTAGGCAATGCCATTCAGGACATAGGCATGGGCAAAG
ATTTCATTATGAAATCACTGAAAGCAATTGCAACAAAAGCAAAAATTGACAAATGGGATCTAGTTAAACT
GAAGAGCTTCTGCATAGCAGAAGAAACTATTATCAGAGCCAAGAGGCAACCTACAGAGTGGGAGAAAATT
TTTGCAATCTATTCATCTGTTAAAGGTCTAATATCCAGATTCTACAAGGAACTCAAACAAATTTACAAGA
AAAAAATCAAACAACCCCATTAAAAGGCGAGCAAAGGACATTAACAGACACTTCTCAAAAGAAGACATTC
ATGCAGCCAACAAACATGAAAAAAAGCTCAACATCACTGATCATTAGAAAAATACAATTGAAAACCACAA
TAAATTACCATCTCATGACAGAATAGTGATTATGAAAAAGTCAAGAAACAACAGATGCTTGTGAGGTTCT
GGAGAAATAGGAACACTTTTACACTGTTGGGAATGTAAATTAGTTCAACCATTGTGGAAGACAGTGTGGC
AAATCCTCAAAGATCTAGAACCAGAAATACCATTTGACCCAGCAATCCCATTTCTGGGTATATACCCAAA
GGAATATAAATCGCTCTGTTACAAAGATATATGCATGCATATGTTCATTGCAGCACTATTCACAATAGCA
AAGGCCTGGAATCAACCAAAATGCCCATCAATGACAGACGAGATAAAGAAAATGTGGAACATATACACCA
TGGAATACTATGCAGCCATCAAAAGGAATGAGATCATGTCCTTTGCAGGAATGTGGATGAAGCTGGAAGC
CATTATCCTCAGCAAACTCATACAAGAACAGAAAACCAAACACTGCATGTTCTCACTTGTAAGTGGGAGC
TGAACAGTGAGAACACATGGACACAGGGAGGGAAACAACATGCACTGGGGCCTCTTGGGGAGTGGGGTTG
GGGGAGGGAGAGCATTAAGAAAAATAGATAATGCATGCTGGGCTTAATACCTAGGTGATGCGTTGGTAGG
TGCAGCAAACCACCAGGGCACAGGTTTACCTATGTAACAAACCTGCACATACTGCACATGTACCCAGAAC
TAAAAATAAAAATTAAAAGAAAGAAATGTATTAATTAGTTCCCCCAACAAATATTTTCTGAATATCTGTA
ACTATGAATTCCATTAAACTTACTCTTCAGGTGTTAAAAAAAAAAAGAAGACATTTATGTGGCCAAGAAA
CATGGAAAAAAGCTCAACATCACTGGTCATTAGAGAAATGCACATCAAAACCACAATGGGATACCATCTC
ACACAGGTCAGAATGGCAATTATTTAGAAGTCAAGAAAAAACAGATGCTGGCAAGGCTGTGGAGAAATAG
AAACTCTTTTACACTGTTGGTGGGAATGTAAATTAGTTCAACTATTCTGGAAGACAATGCGGGGACTCCT
CAAAGACCTAGAGGCAGAAAGACAATTTGACCCAGCAATCCCATTACTGGGTATATACCCAAAAGAATAT
AAATCATTGTTATAAAGATATGTGTATGTGCATGTTCATTGCACGTGTATCTTCATTGCAGCACTATTCA
TAATAGCAAAGACATGAAATCAACCCAAATGCCCATCAATGATAGACCGGATAAAGAAAATGTGGTACGT
ATACACCACGGAATACTATGCAGCCATAAAAAGGAATGAAATCATGTCCTTTGCAGGGACATGGATGAAG
CCAGAAGCCATTATTCTCAGCAAACTAATGCAGGAACAGAAAGCCAAACACCGCATGTTCTTTAAGTGGG
AGCTGAACAATGAGAACACATGGACACAAGAAGGGGAATGACACACACTGGGGCCTGTCGGGGGTGGGGC
AGGGGGGAGAGAGAGCATCAGGAAAAATAGCTAATGTATGCAGGGCTTAATACTTAGGTGAGGTTGATAG
GTGCAGCAAACCACCAGGGCACATGTTTACCTATGTAACAAACTTGCATATCCTGCACGTGTATCCTGGA
ACTTAAAATAAAATGATAAAAAAGAAAAAAGATAAAAATAGGTAAATTGTGCTTCATCAAAATTAAAGAC
TTTTGTGCATCAAAGAACATTATTAAGAAAGTGAAAAGACAACCTACAGAATGGGAGAAAATATTTTCAG
GTCATGTATTAAAGGTCTGGTTCCAAGAATGTATAAACAACTCTTATAACTCAATAGCAAAAAGACAAAT
AATTCAACTAAAATGGGCAAAGGACTTGAATAGACATTTCTCCAAAGAGGATATACAAATGGCCAATAAA
CACTTAAAAAGATACTCAAAATCATTTGTCATTGGGAAAATGTAAATCAAAACCACAATAATATACCACT
TCACACCTATTAGGATGGTGATAATAATCTTTTTAAAAAGGAAAAAAACAAGTGTTGATGAGGATGTGGA
GAAATTATAACTCTTGTACACAGCTAGTGGAAATGTAAAATGGTACAGCCATTGTGGAAAACAGTTTGGC
AATTTCCCAAAAAGTTAAGCATAGAATTATATGATCTGACAAATCCATTCCTAGGTATATACCCAGATAA
AAACAGGTAGTCAAATACTTGTACACATAGCAGCACTATTCGCAAGAGCCAAAAGGCAAAAACAACCCAG
GTGTCCACTGATAGATAAATGGATAAATAAAATGTAGTATATACAGAATACAAAATACTATTCAGCCAAA
AAGGAATGAAGTACTGATACATGGTTCAGCATAGGTGAACCTGGAAAACATGATGCTAAGTGAAAGAAGT
CAGACACGAAAGGTCATATATTGTGTGATTTCATTTATATGAAATTATCCAGAATAGGTAAACCCACAGA
GACAGAAAGCAGATCGGTATTTGCCAGGGGCTGGGGGGGAGGGGAGAATGGGAAATGACTGCTTAGTGGG
TACAGGGTTTCCTTTTGGGGTGATGAAAATGTTTTAGAATAATAGAAGTGGTGGTTTCACAAAATGTACA
AAATGTCACTTTAAAATTATTACATCCTGTTACAAGAATTTCACCTTAATAAAAAATGTCTGAGTGTGAA
CAGAGAAACAATCAAAGCTGAATCTGGGTTAAGGGACCAAAAACAGAGGCATGAACACCTGGAGGTCACA
TTGGAGATTGCAGATTCTGAGAGGTGGAAAAACACGTGTCTGAGGATAATGAAAAAATATAAAACAGCTC
TCTGCCTGTTGAGCACAATAAACATTTGAAAGATGTGGACGGTTGGTAAAAAGTAGATAACACTGCTCGG
GGGCCATCAGGTCACAATCTCTTCACAGAAGAGCATTGCACATTTTGACTCAACCTCAGAATCAGCCCTC
ATGTGTTTGCTTTACTTACATTTCCAACCACTGCTCTCTCCTGGACCTCAGAATACCTATATCTGCTTCC
TGCAAACACACTCAAAGTTAGTTTCTATTTCTTCCTCCCTACAATCCCAGTATGACTGAAGTCCATTGGA
ATTTAGAACCTTGCTGCTTAGTGTGGTCCATGGACAGGCAGCATTGGTGTCACCTGGGAGCCTCTTAGAA
ATGCAGAATCTCAGTCCCTATTCCCCAATCAGCATTTTAATAAGATTCCCCCAAGTAATTTATATGCACA
TTTAAGTTTGACAAATTTCCAACTTTCCATCTATAAAAATCAAAATGAAGAAACAAACGAGATTTATTTT
CTCTAGGAAGTCATGATGCTTGATTTTATTTACAATTATTGTTTTGTTCTGTTAGTTTTGCCACCCAGGG
CTTGAGTTAAAGGAAATGGGATTATTTTTCAATATGGTTTGTCTTTTCCACTAAATTTTCTAAAAGGAGT
CAGGATAGTGCCCAACCCACTTCAAAGAATGTAGGCTGGCATGAGTCATTGTTTTTCATGGTTGTTTCAA
AGATTAATTTCATTTGCCCCACATTTTTGCAACAGTGGTCTTCTTTCCCTTCCTAAATCACTCCAGGCTC
TTTCCTGCATCACGGCTTTTCACACATGATTCCCTCTGCCCTAAAATCTTCTTCATTTGACTTTTCCTGT
TTAACTTTTCACACCCTTTAAATATCAGATGAGATGTTACTTTTCCAGGAAGTCCTTTCTTCATCACTCC
GTCCAAAGCAGGTCCCCGTGTTTTTCTCTATGAAGGTGCCCTGCTTATTTTTTTTGCTGGCCTCACATTT
TCTAATTATGTACACATTTGTGTGAATGTATGACTGTGTGTAAGCTAAGTAGCATAGTGAAGTGGCTATG
AGCACAGACTCCGGAGCCAAGCTTCCTGATTTCCAATTCTAGCAGCCACTTCTCTCCTCCTGGGTCTCAG
AACACCTGCATCTGCCTCCTGTAAACTCATTCAAATGTGTTTCTCTTTCTATACCCATTTCCCCCATAAA
TGTGGGGCAGTGAGCAAGTTACTTTAGTGTTCTGTGCCTTCTTTCCCCATCTGTGAAGTGGAGATTGGAG
CACTGTATATTTCATAGGGTCATTATAAGAAGTATTCATGGAAATAGGGAGAAGAAGAGGAGTTTTAACA
CAAGGACATTCAGAATATTTTATTCTAGAGGTGGAAATAATTTTGCAGGGTGGTAAAAATGAAGCAAAAA
CTCAAGATTCTGCTCCTAGATCAGGAAGTGGCTCTTGAATGAAGGAAAGAATTCTCTCTCTTTCTGCATT
TTATATATATTTCCCAAAGTTCTGTTCTCATTCCAGTTTTCTCCTCAGCTTAACATATCTCTATGCCATT
GATTTTTAAGTCTCTAGCCTCAGCTCTACCCCTAGTCCTAAGTTCCCAGGATCCTCCACGTAACTTCCTC
ATGTATAGCACACTGACATCCTAAAATCAGTAGGTCCAAAATTGAACTCACCTTCCTCCTGTGGCTGCTC
TCCACCTTCCAATTTTGTCACTTTCTTTGGCTATCCTGTCTGAAATTTCACTGCCGTCTTTACCATATTT
CATCTCTCCCTTTCCTTCTTGATTTATTTCTTCCTACCCAATACACTATTTTACTTGTTTATCTTTTTTT
ACAGTTTGTCTCCTGCTAAAATGTTAACTCCATGAGGGCAGGAATTTTTGCTTGCTTTGTTCATGATGTA
TTCATGCAAACTAGAAGAGTGCCAAGCATTCAGTAGGTGCTCAATGAATATTTATTCCTTTCTCATTCCA
ATTACCAATTACTCTACTTAACTCCATATTGATGGGATCTCTTGCTTCAGTCTCTTCTTTCTCTTATGCT
GCTGCCACACTTGTTGAACTGTTATTTTTTCTCATAACTATTACAAGAGCTTGTCGCATGCTGGCTAATG
AAATTTGGGCAAATTATTTAAATTAAGTTCACCTCAGTTCTTCATTTTAAAATGGAGATATTAATAGTAT
AAATTCATAGAATTCTCATGAGACTCATAACGTGTGTACAGCACCTGGCACAATACTTGAAATACAATAA
GTGCTCAGTGAATGCTTCCTACTTTTATCTGCTACCCTGGGCTAGCTCTGGACTAGATTTCCATTGGTCT
CCTGGACTATCTCTGCCTGAATGCTACACTTTGTCTCCCGTGGACCACTTGTAGTTCCCCAAATGTGATA
TGAATCTTCATCTTCTCCATATAATGGACAGCAGGAAACAAGAAGCCAGCTGGATCAGTTCATTCTTTTC
TCACTGCCATATATAATGCATTGCTGGACTAGCTAGCCCTAATTTGCACTAAAGGAGGGGAGAGATGGAA
ACCTTTTTTTTTGCAATGAGCAAAAGGTGAGAGGGTTATTTTTGGTGTGTTTGGTTGGGCCCAGAAAATT
TGGCTCAACTGAATAATAGGTTTTTAATAATTTAGATGAGGATAGTGAGGTTCAGGAAGGATAAGTAACC
TCCCTGAGGTTCACAGTACGATAGTAGATACATTGGTATGAGGGCCCATTTTCTTGGTCTTGGTACTCTT
TATAACACAAGATGCTGGTCATAAACCACAAACAGTCTTGTCTTCAAAAGCTTATTTCCTCTGCCCCAGC
AAATAACTTTCTTACATGCAGACACAATTGAAATTGTTCACCGACAACCATCTCAGGCTTATCGCATCCA
AAGTTGAGAGGAGGTAGTAGTATATCAGGTAACACTGCCAGCGTCCCCTTTCCCGCCCCAATCCCTTGGC
AGAGAGCCAGACAACTGTATACAGACGATTTAGGTTGAGCAAGCTGCACAAAACCAGGGAGTCACTCAGT
GACTACACCGATCTGGATTGACATTTACCTGGGCCAAAGCAGAAGACAAACAGGAGCGATTGGAACAGCC
ACAACATGCTTTCCGCGGTGAAGACTGGTGCTTGAGACCTTGAGGCAGTCAATGTTTTTGCCCTTCTGTC
|
| Protein Name |
SLAF6_HUMAN |
| Length |
332 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
24-MAY-2004 |
| Definition |
RecName: Full=SLAM family member 6; AltName: Full=Activating NK receptor; AltName: Full=NK-T-B-antigen; Short=NTB-A; AltName: CD_antigen=CD352; Flags: Precursor |
| Primary Accession |
Q96DU3 |
| Accession Version |
Q96DU3.3 |
| Other SeqIDs |
sp|Q96DU3.3|SLAF6_HUMAN,gi|205830927 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before May 19, 2012 this sequence version replaced gi:74756457, gi:74756456, Q96DU3.2.; [FUNCTION] Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity). {ECO:0000250|UniProtKB:Q9ET39, ECO:0000269|PubMed:11489943, ECO:0000269|PubMed:16920955, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}.; [SUBUNIT] Homodimer. Interacts with PTN6. Interacts (phosphorylated) with PTN11. Interacts (phosphorylated on tyrosine residues) with SH2D1A/SAP and SH2D1B/EAT2; SH2D1A and SH2D1B can associate with the same SLAMF6 molecule; interaction with SH2D1B is mediated by ITSM 2. {ECO:0000269|PubMed:11489943, ECO:0000269|PubMed:16920955, ECO:0000269|PubMed:17045824}.; [INTERACTION] Q96DU3; Q6PL45-2: BRICD5; NbExp=3; IntAct=EBI-14058448, EBI-12244618; Q96DU3; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-14058448, EBI-12256978; Q96DU3; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-14058448, EBI-10266796; Q96DU3; Q9UI14: RABAC1; NbExp=3; IntAct=EBI-14058448, EBI-712367; Q96DU3; O60880: SH2D1A; NbExp=12; IntAct=EBI-14058448, EBI-6983382; Q96DU3; O14796: SH2D1B; NbExp=4; IntAct=EBI-14058448, EBI-3923013; Q96DU3; P55061: TMBIM6; NbExp=3; IntAct=EBI-14058448, EBI-1045825; Q96DU3; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-14058448, EBI-11724433.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96DU3-1; Sequence=Displayed; Name=2; IsoId=Q96DU3-2; Sequence=VSP_034620; Name=3; IsoId=Q96DU3-3; Sequence=VSP_043230.; [TISSUE SPECIFICITY] Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes (PubMed:11489943). Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients (PubMed:22184727). {ECO:0000269|PubMed:11489943, ECO:0000269|PubMed:22184727}.; [DOMAIN] The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the with the SH2 domain of SH2D1A and SH2D1B. A 'two-out-of-three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3). {ECO:0000250|UniProtKB:Q13291}.; [PTM] Phosphorylation in NK cells upon engagment by SLAMF6-expressing target cells is leading to receptor activation. {ECO:0000269|PubMed:16920955}. |
| Source Db |
UniProtKB: locus SLAF6_HUMAN, accession Q96DU3;; class: standard.; extra accessions:A6NMW2,B2R8X8,Q14CF0,Q5TAS4,Q5TAS6,Q5TAT3,Q96DV0; created: May 24, 2004.; sequence updated: Jul 22, 2008.; annotation updated: Oct 12, 2022.; xrefs: AJ277141.1, CAC59749.1, AJ306388.1, CAC59750.1, AY358159.1, AAQ88526.1, AL832854.1, CAI46161.1, AK125624.1, BAG54223.1, AK301026.1, BAG62642.1, AK313549.1, BAG36325.1, AL138930.15, CH471121.2, EAW52713.1, EAW52715.1, BC113893.1, AAI13894.1, BC114495.1, AAI14496.1, NP_001171643.1, NP_001171644.1, NP_001171645.1, NP_443163.1, 2IF7_A, 2IF7_B, 2IF7_C, 2IF7_D; xrefs (non-sequence databases): CCDS:CCDS1205.1, CCDS:CCDS53393.1, CCDS:CCDS53394.1, PDBsum:2IF7, AlphaFoldDB:Q96DU3, SMR:Q96DU3, BioGRID:125378, IntAct:Q96DU3, STRING:9606.ENSP00000357036, GlyGen:Q96DU3, iPTMnet:Q96DU3, PhosphoSitePlus:Q96DU3, BioMuta:SLAMF6, DMDM:205830927, jPOST:Q96DU3, MassIVE:Q96DU3, MaxQB:Q96DU3, PaxDb:Q96DU3, PeptideAtlas:Q96DU3, PRIDE:Q96DU3, ProteomicsDB:76325, ProteomicsDB:76326, ProteomicsDB:76327, Antibodypedia:34279, DNASU:114836, Ensembl:ENST00000368055.1, Ensembl:ENSP00000357034.1, Ensembl:ENSG00000162739.14, Ensembl:ENST00000368057.8, Ensembl:ENSP00000357036.3, Ensembl:ENST00000368059.7, Ensembl:ENSP00000357038.3, GeneID:114836, KEGG:hsa:114836, MANE-Select:ENST00000368057.8, UCSC:uc001fwd.2, CTD:114836, DisGeNET:114836, GeneCards:SLAMF6, HGNC:21392, HPA:ENSG00000162739, MIM:606446, neXtProt:NX_Q96DU3, OpenTargets:ENSG00000162739, PharmGKB:PA134959277, VEuPathDB:HostDB:ENSG00000162739, eggNOG:ENOG502SSRG, GeneTree:ENSGT01030000234540, HOGENOM:CLU_069386_2_0_1, InParanoid:Q96DU3, OMA:YLDIRWI, OrthoDB:990343at2759, PhylomeDB:Q96DU3, TreeFam:TF334964, PathwayCommons:Q96DU3, Reactome:R-HSA-198933, SignaLink:Q96DU3, BioGRID-ORCS:114836, EvolutionaryTrace:Q96DU3, GeneWiki:SLAMF6, GenomeRNAi:114836, Pharos:Q96DU3, PRO:PR:Q96DU3, Proteomes:UP000005640, RNAct:Q96DU3, Bgee:ENSG00000162739, Genevisible:Q96DU3, GO:0009897, GO:0070062, GO:0016021, GO:0005886, GO:0045087, GO:0032729, GO:0032740, GO:0045954, GO:0042110, GO:0072540, Gene3D:2.60.40.10, InterPro:IPR007110, InterPro:IPR036179, InterPro:IPR013783, InterPro:IPR003599, InterPro:IPR013106, Pfam:PF07686, SMART:SM00409, SUPFAM:SSF48726, PROSITE:PS50835 |
| Sequence |
mlwlfqsllfvfcfgpgnvvsqssltplmvngilgesvtlplefpagekvnfitwlfnetslafivphetkspeihvtnpkqgkrlnftqsyslqlsnlkmedtgsyraqistktsaklssytlrilrqlrniqvtnhsqlfqnmtcelhltcsvedaddnvsfrwealgntlssqpnltvswdprisseqdytciaenavsnlsfsvsaqklcedvkiqytdtkmilfmvsgicivfgfiillllvlrkrrdslslstqrtqgpaesarnleyvsvsptnntvyasvthsnreteiwtprendtitiystinhskeskptfsrataldnvv |
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