|
|
| Record Information |
| Record ID |
191 |
| Pubmed ID |
30906300 |
| SNP |
DPB1?02:01 |
| Gene ID |
3115 |
| Protein ID |
P04441 |
| Vaccine Adverse Events |
antibody immune response |
| Vaccine |
inactivated Japanese encephalitis vaccine |
| Gene Name |
HLA-DPB1 |
| Official Symbol |
major histocompatibility complex, class II, DP beta 1 [Homo sapiens (human)] |
| Aliases |
DPB1, HLA-DP, HLA-DP1B, HLA-DPB |
| Other Designations |
HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA-DP histocompatibility type, beta-1 subunit; MHC HLA DPB1; MHC class II HLA-DP-beta-1; MHC class II antigen DPB1 |
| Chromosome |
6 |
| Location |
6p21.32 |
| Annotation |
Chromosome 6 NC_000006.12 (33075990..33089696) |
| MIM |
142858 |
| DNA Sequence |
>NC_000006.12:33075990-33089696 Homo sapiens chromosome 6, GRCh38.p14 Primary Assembly
CCTTCTTTTCCTGACTGCAGCTCTTTTCATTTTGCCATCCTTTTCCAGCTCCATGATGGTTCTGCAGGTT
TCTGCGGCCCCCCGGACAGTGGCTCTGACGGCGTTACTGATGGTGCTGCTCACATCTGTGGTCCAGGGCA
GGGCCACTCCAGGTAAGAGCCGAACTGCCATTCTTGGAGGGTCTGGCTCAGGGAACAATTCCTAGGGGAC
GTTATCTTTAAGGGATCAAATTCTGAGACAGGCTGCGGGGGCTCCTGCCCTAAGGCAGTGTCCTCTCTTC
CCAGCTAGAGAAAGAGGTTCATCCCCTATAGGATAGCTTGCTACCCTACTGGCCTATTCTCTCTCCAAGG
ACATGGGTACAGTAAACAGAGAGAGGTGCCCAGTGGTCAGTGTCTTTGGGGAAAATGGGACCAAGAGGTC
CTGGATAACCTTGGACAGACAAGGTTTGCAGAGAGAGAAGTTGGCAAGTGCAGGCTCCTGGGCGTGTTCA
TGTCTGCATCCAGCCTGGAGGGGACTCAGGCAGAGAGCCCTAAGCTGGAGTGTCCAGGCTCTGAGGATCA
CTGAGGATTCAGTGCTCACGAAGAATGCCTCTTATTCCCCAGGGTGGAGCAGGAGCCCACATCCCTTGGA
CAATTAAGGAGAGAAGGGAGGGAGGGGGATAGGTTTTAGCCCCTGAAGGCATTCTCATTAAAGGTACTTC
TCCCAGCCTCCCCAGAACTTGGTTAGGGTACTAGAGTGGGTTGCGACTTGTAGGAAGAATGAGATGAGGT
TGTGTGGGTGCATGACAGGGATTGAGTGTAGGTTATCAGACAGCCAAGGAAGCAGTAACCAAGTGAAAAA
TCTCTTCTTCCTGCTGCCTCCCTGTGGCTGGTGTAATATTATGGCATCTATGATCCATTGTTTTTCTCTC
AGGATACTCTCAGGATATTTCTTTTTATATATATATATACTTTAAGTTCTAGGGTACATGTGCACAACGT
GCAGGTTTGTTACATATGTATACATGTGCCATGTTGGTGTGCTGCACCCATTAACTCGTCATTTACATTA
GGTATATTTCCTAATGCTATCCCTCCCCCCTCCCCCCACCCCACAACAGGCCCCGGTGTATGATGTTCCC
CTTCCTGTGTCCATGTGTTCTCATTGTTCAGTTCCCACCTATGAGTGAGAACATGTGGTCTTTGGTTTTT
TGTCCTTGCAATAGTTTGCTGTGAATGATGATTTCCAGCTTCCTCCATGTCCCTACAAAGGACATGAACT
CATCCTTTTTTATGGCTGCACAGTATTCCATGGTGTATATGTGTGCATTTTCTTAATCCAGTCTATCACT
GATGGACAGTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAATAGTGCCGCAATAAACATATGTGTGCATG
TGTCTTTATAGCAGCATGATTTATAATCCTTTGGGTATATATCCAGTAATGGGATGGCTGGGTCAAATGG
TATTTCTAGTTCTAGATCTTTGAGGAATTGCCACACTGTCTTGAGATACCATCTCACACCAGTTAAAATG
GCGATCATTAAAAAGTCAGGAAACAACAGGTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACTCT
GTTGGTGGGACTGTAAACTAGTTCAACCATTGTACTCTCAGGACATTTCTAGTCCAAATTTACACCAACA
CTCTGAGAGGAAGGACTGCAAAGTAGGTACCTTAGTTTTCCACTGACTTCCACTTTTCCTGCTTACACCC
TTCCTCCTAGACCTCTCCACACCCCTCCTAGGACACACCTAGAAGGTACTGACATCATGTCACCTCCTCA
TCTTTCAGGGTAGCAAGGTTGGAATCTCCTGAATACAGCCCCTCAAGCCCTAAAACCTCTTATCTATTAC
CTTGGGTTCATTGTCCAGGAAGGGGAGGAGAACTTGAACTTGTAGTCACAGAAGGGTGCTGAGAACTAAC
CAGCAGGACGGCTCAGCCCTGGGAACTGCAGAGGGGTGAGGCTGGGGAGAGAGGAGGCTGGAGCAGCACT
GGTGACACTGAACAGTGTCAGGAGGAAGTGACGGATGCAGCGCCCCCATCCCATAGGCAGAGCTGTCATG
TGGGATGAGGGACAGTGTTGGGAGCCACCAAGGAAACCCAGAGGTGGGGGAGCAGAGAGCAGAAGGGGGC
ATGTGATGCTGGGCAGTGAAAGGGAGGACGGGCAAAGGCTGGGTTGAGGTTTGTAGGGGGAATGAGATGA
GGCAGTGGAGCCATGTGACAGGGACTGAGGGTAGATTACTGGAGCTCCCTGCGTAGAATGAATGTTCAAT
CAAAACCTGCTGGAGGGAGAGCTGGAGCCATAGGGGAGTGGGTAAAGTGGGCAGGGCTGATTCCACAATT
CCCTGCATGCTCCCCCAACTCCACACACATCCCCAACCTCAAACAGGGCACAAGACCAAAGGGCTGAGGA
GCCAGGCTATAGCTTAAAGAGGCTGGGGGAGAAAAGCTTGGCTGAGACAACCCATAGGGAGCTAGAGGTT
TTTAATATATCCTATTCTGAATAAGAGACGAATTCATTCAGATCAGTGGTTTCAAACCGTGCTCTGGGCA
ACTCAATTGCTAAGGGTTCCACAAACAGGATAAAGTTTCTTATATACAAAAAAAAATGAAGGTTTCAAAT
TACACCATAAAACCCCTCATTGCTTATGTCTACTTGGCAGGTAAAATTCCATTTCAAAAGTTAAATGTAC
TTAAAAAATTACCTAAGACTGGGTAAATTAAAAAAATTAAATGTTGCAAAGAAAAAATTCAAAATTCTTA
TTCTTGAATGAAAAACGTTCTCTTACTGGTGATTGAGGAGGAGAAACAAAGACTAACAAATGAAAATGGG
AGAATCCACACTCAGAGTGGGGCAATTGAACAGGCAGGGGCGGATGGATGGCAGAGGAGGAGGAATCTGG
ACTCAAGGAGCTGGGGGGCTCTGGGCCTGGAATTTTAGGGTCTGGGGCCCAAGGCACCAGGAGAAGAGGC
AGGTCAGGATATCTGAGTCAAGACCTGGGATCTTGCCTTAGCAATGACACTGGAGACTAAAGGTGGACTC
CATGGTGCCCTTGAGCCCAGCCCTACCCCATCTCCACTATCCTCTGCCACCAGCTGTGCAACTTCTGCTA
GGGGTGAGGTTAATAAACTGGAGAAGTTAATTTGTGGAGCATGAAACAGATGAGCAGAACAATCACAGCA
CCTTAATTTCCCCAGTGTGCCCAAGAACAGAGCAGGCCTGAAGATACTCAAACAGAAACAAACATGTGCC
GTGTCACTGATAATTCTGTGTAGACACACACCTGCCAGACACTGCTCATGGCACTCCCTAGGAAGAACAG
CATGTGGGAAAGGCTGCCAAAATTGTTCATGTAAAAATTACATCAATGCTGTCTTCCTCGGTGCTGCCTA
TGCAGCTGGCAGCCATCTCTTCCTCCACATCATGGCCTCCCTCAGACTCCTCATGAAGGATAAGATCCTC
AAAAAGAGGACCAACAAGTTCATGAGGCACCAATCAGACTGAAATGTCAAAATTAAGCATAACTGGCGGA
AACCCAGAGGTCTTAACAGTAGGGTTCGTAGAAGGTCCAAGGGCCAGATCTTGATGCCCAACATTGCTTA
TGGGAGCAACAACAACAACAAAAAAAACATGCTGCCCAGTGGCTTCCAGAAGTTTCTGGTCCACAGCCTC
AAGGAGCTGAAAGTGCTGCTGATGTGCAACAAATCTTACTGTGCTGAGATCGCTCACAAAATTTCCTCCA
GAACTGCAAAGTCATCATGGAAAGAGTCACCCAGCCGGCCATCAGAGTCACCAACCCCAGTACCAGGGTG
CACAGCTAAGAAAATGAGTAGAAAGTTCATGTCCACGTTTTGTGTGTAAATAAAACCATAAAAACTGCCA
AAAAAAATTACATCAATGCCTCTAAACCCAAAGGACTCTACCCCCACAGGTCCCTGGTTGTTGTGGTGAT
TTTCATTGTGTAAAATACTTTCCACATCTTTTGACACCAAGTCTTTCTGCAGCCATGTTTGAAAATTAAC
TTTCAGGCTACAGAGTCTTTCTTATACCAAAGTTGAAGAAAGTTTTAAGAAATATATTTCTACATCTCCT
ACATGCAAAACAACAGGAGCAAGTTGAGGAATTCTCAAGAAACTGGTCGAGAAGAGAGAGCGCTTAGCTA
TGGAAAAGAGAAAGAAGGAAGGGAGGGCTTCCTGGAGGAGGTGGCATTTGAACCAGGACTGACATCAGGA
TGGAAATGTCAGTCAGGGAGTTAAGTAGGGGGAGCAGCTCCGCCCTCCACGTCCCCAGCTCCTCCCGCCC
CTGTTTTTTCTCCCAGTGACCCCACGTGAAACGTCTCCGCCTCCTCCAGCCACCAGCAGAAGGGACTGCC
TTCCCCTCAGTGCTCGCCCCTCCCTAGTGATCACTCAGTGCCCCTGAGCTCATTCTTTTCAGTAAATTCT
CTCTCTGCGTGGTGAGAAAACAGGCCTGGAGAGGCTCTGCGACCCGCTTAGGACCACAGAACTCGGTACT
AGGAAAACTCCTATTTTAAAATCCAGCCCTGGGTGGGAAGATTTGGGAAGAATCGTTAATATTGAGAGAG
AGAGGGAGAAAGAGGATTAGATGAGAGTGGCGCCTCCGCTCATGTCCGCCCCCTCCCCGCAGAGAATTAC
CTTTTCCAGGGACGGCAGGAATGCTACGCGTTTAATGGGACACAGCGCTTCCTGGAGAGATACATCTACA
ACCGGGAGGAGTTCGCGCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTGACGGAGCTGGGGCGGCC
TGCTGCGGAGTACTGGAACAGCCAGAAGGACATCCTGGAGGAGAAGCGGGCAGTGCCGGACAGGATGTGC
AGACACAACTACGAGCTGGGCGGGCCCATGACCCTGCAGCGCCGAGGTGAGTGAGGGCTTTGGGCCGGCG
GTCCCAGGGCAGCCCCGCGGGCCCGTGCCCAGGGCGCAGGAGCAGCCGGGTTGGCCTAAGGGACCTTAGT
GCCGGGCGGAAAGGGGACTTTGGGTTGGGGATTCATGGGGGGAGCCCATCTGGAGCTTGTCAGGGGAGCG
AGCGCGGGGACCTGGACTGGGCTGAGCATGGAGTGAGGAGGACGAGAGCAGAGAGACCCCCGGGACTTCA
TCAGGCCTGGCAGCTGACTGCATGTGGGGTGAAAAAAGGAAGCCACAGGACAGCGCACAAGGGTATGGTG
TGGAGATGGAGGTGGAGATGGCACAGCAGGCCACACAGAGAAGAAACCTACAGGGAGGTAGCTGGGTTTG
AGGTGCTTGAGGGGCAGATGGGTGGTCTGATGGGCAGGTAGACAGAAGGGTCTGCAGCCGGGGAGGAGAC
TGAGATACATGAGACCATCCAGGGAGAGGGGACCCAGGGGGAAGAGCAAAGGACCGGATCCTGGGAACTG
GACAGTTGTGATTTGGCCAAGACAGAAAAGCCTGTGAAAGAGACCAAAAAAACCCAAGTGCAGTGTGAGG
AGAGGCCCGCAGAGAAGAGTCTTGGAAGCTGAGGGGAGGTGACCTCAGCAGCACAGTGGACAGCGGTGCC
AGTGACTTGGGAAGGTCAGAAAACAGAAGATGGAAAGTGGGTTTGGAAACCAGGGAGACCTGGGGAGAGC
AGGTTGGCCGCAGCGGCAGGAGCTGGAATGGGAGGGGGTGCATGAGGCTGAGTGTGGCGCATCCTCCTCG
GGGCTGAGATGGATTTTACTTGTCTTGGGTTCCCCACGGCTGTCACAGGGCAGTGTCTCAGTTCATTCGT
CTTTTTCCTTCAGGAAGTCTGGGTGTAAAGGGATGGAGAGAGGTGAGGTGTGTGCAGTAAGAGGATTTCT
CAAGGATGGGACAGGAAGGCCTTGGAGCTTTGGCTTCCTCCTGTGAACTTGTGGGGTGGGGAGCCTGGTG
CACCAACCTGAGGGACTTGAGGGAGTAGTATCAGGATGTGGGATTGAGCCCTGGACCTTTTTTCTAGAAA
GAGGAAAAAAATGAAGGGAGGAGGAGGAGGAAGCTGGGGAGATCACACCTTTGATTTTCTTGTTCCTGGA
AAGTGAAAGGAAGTTCACCTGCTATGAGTGAGAAGGTGGACACACTGGGTGGGGATGAGGTGAGTGACAT
GAGCTTAGGAAAGTTGCTGAGGTAATTGGTTGAGAGAGGTGTTCAAATAAAAATAACGCAATTGGCAAAA
ACTGTTACTAAGACTTTGTAGAGGCACCAATCAGTGACATGGCAGCATTTTCTTTCACAGTAATCAACTG
CCAGATTGCAGACAGCCCTGATGCCAGCCTAAGGAGTGTGGGTTTCTCCTCCAGGCCCGCAGGTCCCCAA
CCTCACTCCTCTGAAGACTCTTCTGGAGATCCTCTGTGATGCACAGATCTCCAGACTCAGTGCCCCCAGA
CTCAGATTCCCTGGGTGGGGAGGTCTGGGGATCTCTGCTTGTAATCAGCTCCCTAGAGGTTCCCATGTAG
CCAGATAAGTATTGTCAGAACACTGAAGATTTTTGAAAAATGAAAAAGAGAAGGTTGGAGATGTGTCTTC
AGAAGACTACTAAGGGTGCTGGCTAGAGGAGGGACCAGAGGCAGGGAGATGAGGTAGGAAACTGCTATTA
TTTGTCAGGGAAATTGCAATCAAGGCATGAGTTAGAACAGGGAAAACACAGAGGCAAGGGAGAGGTGGAA
GGGGGAGGAAAGAAGTAGTGACAATTCCAGGGTGGATGTCCACCCAAATCTAGAAGTAATTGAGCAAATG
TTTTCTGGGCATTAGAGAAGGCAACTAGAACAAACAGGAATCCTTGCCTTGGTGAAATGTATTTGAACTG
GGTCAGAAATGAGGCCATTGGGTATCAGGCCTTAACTCCAGCGCACCCTGGAGGTCACTGATGTGGCTCC
AGGCTGACCTGCTCCTGTCAAAGAATATTGAGCAAGATGCCTCTCGTGGAATGTTCTGGGACCTTAAAAC
AGATACCCAAGTATTCCCCCTGATTTCATGGTTCCCAGAAGCTCTATGGGGAAGAAATTGTAGGTAATTC
ACAACTGAGATTTAGACATAAGTTGAATAGTGTAATGGACATTGAGTTAACCGAGGTAATGAAGTAGTGA
GACACAGGTGCCCCTGAAATAAACTCACATTGAGGGAAGAGGCTGACAATGTGGATCAGTCTGAAAACAA
GGCAAAAATACAATAGGGAGTAAGGGTTGTGTGTCAGTTCAAGACTGTACTTTTACCTGGCCCAGCGCCA
TGTTAGGGTATTTGTGTTCTCCAGGAAGTAGAAAGGAAAGAACTGAGTGATTAGGGACCTAGAAGACTAA
TTTGAGACATTCCTCTTGATGAGCTGTTCTCTAGGGTAGTCCTCTGAAAGAGCTGTTCTCTAGTGGATCT
CCCTGAATGAACTGTTCTCTAGGAGCACTTGACCCTTTTCTGTGTTTGTTTTTTGTTTTGTGTTTGTGTT
TGTTTTTGAGACAGGTTCTCACTTTGTCTCCCAGGCTGGAGTGCTGTGGCACCATCATGGCTCACTGCAG
CCTCAACCTCCTGGGCTCAAGTGATCCTCCTGCCTCAGCCTCCCATGTAGCTAGAACTACAGATACACGT
ACCACCATGTCTGGCTAATTTATTTTTCTTTTTAGAGATGGGTTCTCACTATGTTGCCCAGGCCGGTCTC
AAAACCCTGGGCTCAAGTGATCCTCATGCCTCAACCTCCCAAAGTGCTAAGATTATAGGCATGACCACCA
TGCCTGGCCTTTTCTGCTTTCTGAGGAGGAAAAAGGTACTGGTGGCAGAGATCCAAAAGAAAAGTTGCCA
GTGGCAGTGTGGAAATTCACCTGAGAACAACAGGACAAGCTGGGGCACAAATGCAAAGATGCAGAGGGAG
GCAACACCTGGTCATCTGTGAGACCTTCATGGGACCTGAAGACGCAGCACAGAGGAGGAACTTGAAAAAG
GACGGGATTTCTACTACTCAAGCATGTAGGAGCTCAGGATATTCTGTAAATATGAAGATTTTGAGTTTTT
GTAGGTGAGGTAAAAAAATACATAGGTTTTTTACAGAATAAGACATGTAAAGCTCTCTTCATTTTCTTTG
TATTTTCATGAAGTTATTAGATTCACAGGCCACCATAATGCCATTGTCTGTATATCTTAATTTCAAGATA
TTATTTGAGTAAATTTTGCTTCCTTTGTATCAAGATAGAACTTTGAAAAGGTAGGTAATTTCACAGTTGA
TCAAATATTCTTTGCCCAAATTACTTTTGGTTAAAATTTCTCCTAAATGTGCTACAGAGTGCAAACTCTG
TCTCCCTGCCATTCCGCTATATACTTACTAACTATTATTTTATTCAAGATCATGCATGCTCTACTTGAAG
GTCTATTTCTATCTTTTCAATGCTACCCTTACCCACTAGCCTAATCACATTATTCCTATTTTCAACATCT
AGGAATCAATTACATAGTGAACATGCCTAAGAAATAATAATCTGGGCAGATGCAGTGGCTCAGGCCCGTA
ATCCCAGCCCTTTGAGAGGCCGAGCGGGTGGATCACTTGAGGTCAGGCGTTGGTCAAGTGCTCCTAGAGA
ACCAGGCTGACCAACATGGAGAAACCTTGTCTCTACTAATAATACAAAAATTAGCCAGGTGAAGTGGCAG
GCACCTATAATCCCAGCTATTCGGGAGGCTGAGGAAGGAGAATTGGTTGAAGCCCGGAGGTGGAGGTTGC
AGTGAGCCAATATTGCGCCACTGCATTCCAGACTTGGCAACAGAGTGACACTCCATCTCAACAAAAAGAA
AGAATGAAAGAAAGAAAGAGCGAGATTATGTCTCAAAAAAAAGGAAGGAAGGAAGGAAGGAAGGAAGGAA
GGAAGGAAGGAAGGAAGGAAAGAAGGACAATCTCAAATTCTATTTCATTATTTTTCTTCCACGCTCCTAG
TCCAGCCTAGGGTGAATGTTTCCCCCTCCAAGAAGGGGCCCTTGCAGCACCACAACCTGCTTGTCTGCCA
CGTGACGGATTTCTACCCAGGCAGCATTCAAGTCCGATGGTTCCTGAATGGACAGGAGGAAACAGCTGGG
GTCGTGTCCACCAACCTGATCCGTAATGGAGACTGGACCTTCCAGATCCTGGTGATGCTGGAAATGACCC
CCCAGCAGGGAGATGTCTACACCTGCCAAGTGGAGCACACCAGCCTGGATAGTCCTGTCACCGTGGAGTG
GAGTGAGTCTCTGATGACCCTCTAGACCCCACCTCTGAAGAGCAGGGGACTCTCTGGCTCTGGGGTCCAC
TCATCTTATCTTCTGCATCTATACCCTGGGGCCATGTCCAAACCCCATCTTTCTTCTATACCAGCTCCTG
AGCATAGTTTGAAGCCAGGGAAATGGAGACTTCCTGACCTTGGCTTAGGGGTTCCTGAAGATTCATAGTT
CTCCCCCTTGTCAGAGAATCTAGGGACACTGACTGGTCTCGAAACCCTCACACTTAGGAACTGACCTCAC
ACATAGGAACAGTTCTCTTCCTTCAGCATTTTAGCCTCTTCTCAGGCATTTTGAGAGGCAACTTCCAGAA
TCAGCATTTGCCACCTTGTTGAGGTCACACCCCTGTTCCAGATATGAGGGTGGCTCTTTCTGAATTTCCT
CTTAGCAAGCTTTTTCCGCTGCACTGTCCTCATCCCGATATGCTGCATCAGGCTCCAGAATCTCAGACAG
GACATGAGTAGGGATGCAGCTGGTGGAGGTGACACTAAACCTGGGTCTGTCCTTCCCAGAGGCACAGTCT
GATTCTGCCCGGAGTAAGACATTGACGGGAGCTGGGGGCTTCGTGCTGGGGCTCATCATCTGTGGAGTGG
GCATCTTCATGCACAGGAGGAGCAAGAAAGGTGAGAAAGCCTGCAGGGTGAGCGGGACTTACCTTCCCCT
GGCATATTCACACTTATTCCACGATGAGGGGTTTGACAGAAAAGAAATGTCAGAAAGCTCTAGAGGCCAC
TGATATCAGATAATCGGGGAACAAACATGACCTATAGCGAGAGAGGGATCCCAGGCTGGGATCTTAATGC
AGCCAGATGCATGAGGTCCCAAGTACTCAGGCTCCTGCGGAGCGTCCATTGAGTGATGGGCAATGGAATT
TGGTGGGATGGAAATGTTTCTCTAATTATCTGAGGTGGTTTCAATGGCTGATTATATAACCTTTCGTCTT
TCATTTCAGTTCAACGAGGATCTGCATAAACAGGTAATATTCCTGCTTTGATTTCCTTGTGGGGTGGGTT
GCAGGAGGATATGAGTCCTTTCTGTGCATTGTAACACTGAGGCTCCTCCAGGAAGGGAATCTCAGGCATG
AACCCCTCTTTCAATGTCAGCCTTCAGGCAAGTGGGGAAAGAGCATTGCTTGGCTCCATTGCTGAAGGAA
GCAGAGATCAACTCTGTTATTTATCAGCCTGAGACGCATCCTCTCACCATAATTTTTCTCTCCTGGACTT
ACAGGAAGGAGGCTGGCAACCTGGGATAACTTGTCTTTTACCCCCACAGGGTTCCTGAGCTCACTGAAAA
GACTATTGTGCCTTAGGAAAAGCATTTGCTGTGTTTCGTTAGCATCTGGCTCCAGGACAGACCTTCAACT
TCCAAATTGGATACTGCTGCCAAGAAGTTGCTCTGAAGTCAGTTTCTATCATTCTGCTCTTTGATTCAAA
GCACTGTTTCTCTCACTGGGCCTCCAACCATGTTCCCTTCTTCTTAGCACCACAAATAATCAAAACCCAA
CATGACTGTTTGTTTTCCTTTAAAAATATGCACCAAATCATCTCTCATCACTTTTCTCTGAGGGTTTTAG
TAGACAGTAGGAGTTAATAAAGAAGTTCATTTTGGTTTAAACATAGGAAAGAAGAGAACCATGAAAATGG
GGATATGTTAACTATTGTATAATGGGGCCTGTTACACATGACACTCTTCTGAATTGACTGTATTTCAGTG
AGCTGCCCCCAAATCAAGTTTAGTGCCCTCATCCATTTATGTCTCAGACCACTATTCTTAACTATTCAAT
GGTGAGCAGACTGCAAATCTGCCTGATAGGACCCATATTCCCACAGCACTAATTCAACATATACCTTACT
GAGAGCATGTTTTATCATTACCATTAAGAAGTTAAATGAACATCAGAATTTAAAATCATAAATATAATCT
AATACACTTTAACCATTTTCTTTGTGTGCCATCACAAATACTCCTTAACCAAATACGGCTTGGACTTTTG
AATGCATCCAATAGACGTCATTTGTCGTCTAAGTCTGCATTCATCCACCAGCCTAGGCCTCCTGTCTTAA
TTTTCATACAGACAGAAATGACTCCCCACTGGGGAAAGAGCAAAGCAATACATGTAGCACTCTTTTTCAA
ACACTGGTCTTTTTTTTTTTCTTAACAATCCAACATTGTTATGTGTTTTGCGTCTCATATTGACACCTTT
TGGTCAAGGTAGAGGACATGTTTGTTGTAAGCTTTCTTTTTCGTGTAGAGGATGGATTCTTCACTCCTGA
TACACACAATCAGTGCACAGCAGCTCTCTTATACATCCAGTTGATGCCTTCAGTCTCCCTGGCTTCTTAC
AAGCATCTTCTGGGCCTTGTGTGTCCCTGGGCACCTGTCCCTGGTCAATTCCCGAAAGCTACTGTGCTCC
TCTTGCCCATCTCCCCTTGCAAATAATATCTTCCATCGGGGGACCGGCTTCCTCCAATTTCAGGAGAGGT
GGGGCTGAAGGCACAGACTTGGGCGTCACTGGCACAGATATAAGTAAATACAGCTGGAGTCTGCAGAGAG
GCTGGACTGAGTCAGGGAGTCAGGAAAGAGAAGCCACACACAAGGACAACCAATCATGTTTCTCATAATC
TTCTTAACCTAGGGAATAGGACACAATCATTTTTTCTTTTTAAAACATCTTTATCCCTGATCAGCCTCAT
TTCCTCAAAAACTATAAAGGAAAATGCTGCTGACTTGTTTTTGCGTAGTAATTTCAGCTGTCACATAATA
AGCTAAGGAAGACAGTATATAGTAAATAAGGACCCTTTATCTGTCTTATTTTCCCTTTTGGCTTCACAGG
AAACTTGTGAGAAACCTATGCAGCATAAAATTAATATGATTTCAATCCAGGGATTCAACGATGGAAGGAG
GTCATGAGAATAGCAGAAAGTCTTCAAATCGAGATCATTATGAAATCCTCAGACCCAGAGCACATAAATC
CTACCCTCAGAGTCACTGAGCAGTTAACATTACAAATTACAAACCATATCCAGTCAGAGTCATTCTCTTT
CCTGCTTGTCTCCTGTACTCATGTTACAGGTTAGGGCAGTACCCCGAGTGGAGTGAACAATCTCTGGACT
AACACTTGTCAGGATCAGAAGCTGAGGTATCTGCACCCACATTACAGGAACAGGATATGTGCTCCTAGGG
AACTGAGGGTGTCAGGAGATGAGGAATGTCCCTGGAGTCACAGAAAGAAGGTATCAGATGTGTCTCACTC
TGACATATGCAGGTGTTTATGAAACTCTGGGATTTCTAAGGAAGGATGCAGTGCAGAGACAGGTCCCAGA
GGAGACAAGAGCTGAGAGACCATCCAAACTGGGACCACCTTGTCACTAGACTTCAAATTTTCAATATTGA
TAGAGTGTTTTCTAAGAGTCAGGCCCTTTGCTGAGTGCTATGTGCAGCAGGATCAAAGGCAGCCAGGAGG
TAGAGGAGTCTTGAGGTACATCAGTCATTGGAGTTGAAGAGCAGAGATTCAAAGGAAAGTTGGAACTGGA
GCTTTAAAGGAGATGTGAAGTGGGTGACTCAACCTCTGACTCAGAAAAATTGATACCTGCAGAAGAAAAA
ACCCGGCGGGCTTAGGACTCCCAGCTGAGTGTTGTATCCTCCATCCCTTTCCACCTGGTCCCTTCATTTT
CTACCCCTCACAGTTCCCTAACGAGAAGGTGGTCCACCCAACAGACAACACTGCCTCAGATGGTTATCAA
GGGGTACCCTAAGAAGAAATCATCTCACCCTCTCTTTGTCCCCATTTGTCAAGTAGCAGTGAGGCCGAGC
CAGGGGATGGTGAAAGTGGAAGGAGGTGGGAGTTGGGCATCGGGTGTGAAGATGCTCTTGAAAGGGGTTT
TAATAACCACTTGCTACCAGGCCAGTGAACACTTACCATAGTTGATGCCTTTTGAGCATGTTGCATTGTA
AACTGTCCCTGAAATTACTGTGCACTTGGCTTATGGGATGAAACATCCTCCTAGTTCTTTTGTCTCTCAG
CTTCTCTGAAGTCTCATTGAGCACCTTCTCTTCAATTTCTTTTACACAGTAAGAATAGGATCAGCTGTGC
TAAACTAACAAATACCCAGATATCCAGGTTTGGCTCATGTTACACGTCCAAAGTAAGTCATGCAGGAAGC
TCTGCTCATCATCGTACTCAGGAAGTCAGGCTGACAGTCTTTCTCCTGCACATCTGCTCCCAGAACCTCC
CCAGCAGAATGAAGGGAACCTAAGAATTTATTCACTGGCTTTTAATGATCCCTCCTAGAAAGAACACACT
TCTCGCATTTCATTTTCCAATGTAAATCATATGGCTGCAACTAACTTCAAATAAGTGGGAATACTTGAAG
GTGGAAAACATTTAAGAAGTACACACTAAATAAATAATAAAATACTTCTACAAGAGA
|
| Protein Name |
HG2A_MOUSE |
| Length |
279 |
| Moltype |
AA |
| Topology |
linear |
| Division |
ROD |
| Update Date |
12-OCT-2022 |
| Create Date |
13-AUG-1987 |
| Definition |
RecName: Full=H-2 class II histocompatibility antigen gamma chain; AltName: Full=Ia antigen-associated invariant chain; Short=Ii; Short=Ii chain; AltName: Full=MHC class II-associated invariant chain; AltName: CD_antigen=CD74; Contains: RecName: Full=Class-II-associated invariant chain peptide; Short=CLIP |
| Primary Accession |
P04441 |
| Accession Version |
P04441.3 |
| Other SeqIDs |
sp|P04441.3|HG2A_MOUSE,gi|123110 |
| Organism |
Mus musculus |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus |
| Comment |
On Mar 15, 2005 this sequence version replaced gi:2144713.; [FUNCTION] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. {ECO:0000269|PubMed:8343954, ECO:0000269|PubMed:8977190}.; [FUNCTION] [Isoform Long]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). {ECO:0000269|PubMed:11483509, ECO:0000269|PubMed:12417635}.; [FUNCTION] [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000250|UniProtKB:P04233}.; [SUBUNIT] Nonamer composed of three alpha/beta/gamma heterotrimers. Interacts with CD44; this complex is essential for the MIF-induced signaling cascade that results in B cell survival. {ECO:0000250, ECO:0000269|PubMed:8343954}.; [SUBUNIT] [Isoform Long]: Interacts with the mature form of CTSL; the complex survive in neutral pH environment. {ECO:0000269|PubMed:11483509, ECO:0000269|PubMed:12417635}.; [SUBCELLULAR LOCATION] [Isoform Long]: Late endosome {ECO:0000269|PubMed:11483509}. Lysosome {ECO:0000269|PubMed:11483509}.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000250|UniProtKB:P04233}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P04233}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04233}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P04233}. Endosome {ECO:0000250|UniProtKB:P04233}. Lysosome {ECO:0000250|UniProtKB:P04233}. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane. {ECO:0000250|UniProtKB:P04233}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=Long; Synonyms=p41 {ECO:0000303|PubMed:11483509, ECO:0000303|PubMed:12417635, ECO:0000303|PubMed:8977190}; IsoId=P04441-1; Sequence=Displayed; Name=Short; Synonyms=p31 {ECO:0000303|PubMed:8977190}; IsoId=P04441-2; Sequence=VSP_005332.; [TISSUE SPECIFICITY] [Isoform Long]: Expressed in thymus and lymph noodes (PubMed:8977190). Expressed by antigen-presenting cells (APCs) (PubMed:11483509, PubMed:12417635). {ECO:0000269|PubMed:11483509, ECO:0000269|PubMed:12417635, ECO:0000269|PubMed:8977190}.; [TISSUE SPECIFICITY] [Isoform Short]: Expressed in thymus and lymph noodes. {ECO:0000269|PubMed:8977190}.; [INDUCTION] Expression is induced by IFNG and LPS, through CIITA. {ECO:0000269|PubMed:32855215}.; [DISRUPTION PHENOTYPE] Mutants for Long isoform or Short isoform exhibit similar functional capabilities. {ECO:0000269|PubMed:8977190}. |
| Source Db |
UniProtKB: locus HG2A_MOUSE, accession P04441;; class: standard.; extra accessions:O19452; created: Aug 13, 1987.; sequence updated: Nov 1, 1991.; annotation updated: Oct 12, 2022.; xrefs: X05428.1, CAA29010.1, X05429.1, CAA29012.2, X05430.1, CAB37297.1, X13414.1, BC003476.1, AAH03476.1, X07129.1, CAA30141.1, M35872.1, AAA37897.1, X00496.1, CAA25191.1, HLHMSG, NP_001036070.1; xrefs (non-sequence databases): CCDS:CCDS37835.1, CCDS:CCDS50299.1, AlphaFoldDB:P04441, BioGRID:200600, CORUM:P04441, IntAct:P04441, MINT:P04441, STRING:10090.ENSMUSP00000095171, MEROPS:I31.002, GlyGen:P04441, iPTMnet:P04441, PhosphoSitePlus:P04441, SwissPalm:P04441, EPD:P04441, PaxDb:P04441, PeptideAtlas:P04441, PRIDE:P04441, ProteomicsDB:269741, ProteomicsDB:269742, Antibodypedia:2245, DNASU:16149, Ensembl:ENSMUST00000050487, Ensembl:ENSMUSP00000057836, Ensembl:ENSMUSG00000024610, Ensembl:ENSMUST00000097563, Ensembl:ENSMUSP00000095171, Ensembl:ENSMUST00000167610, Ensembl:ENSMUSP00000126688, GeneID:16149, KEGG:mmu:16149, UCSC:uc008faz.1, CTD:972, MGI:96534, VEuPathDB:HostDB:ENSMUSG00000024610, eggNOG:KOG1214, GeneTree:ENSGT00390000008961, HOGENOM:CLU_086066_1_0_1, InParanoid:P04441, OMA:GTFRPQC, PhylomeDB:P04441, TreeFam:TF317779, Reactome:R-MMU-202733, Reactome:R-MMU-2132295, BioGRID-ORCS:16149, ChiTaRS:Cd74, PRO:PR:P04441, Proteomes:UP000000589, RNAct:P04441, Bgee:ENSMUSG00000024610, ExpressionAtlas:P04441, Genevisible:P04441, GO:0009986, GO:0005737, GO:0005783, GO:0005789, GO:0009897, GO:0005615, GO:0005794, GO:0016021, GO:0005887, GO:0005770, GO:0005764, GO:0035692, GO:0042613, GO:0005771, GO:0035693, GO:0005634, GO:0005886, GO:0032991, GO:0005773, GO:0001540, GO:0042609, GO:0019955, GO:0004896, GO:0035718, GO:0042289, GO:0042658, GO:0023026, GO:0050998, GO:0044183, GO:0019882, GO:0019886, GO:0008283, GO:0051085, GO:0006952, GO:0016064, GO:0006886, GO:0035691, GO:0043066, GO:0030336, GO:0043518, GO:1902166, GO:0002906, GO:0002792, GO:0045581, GO:0046597, GO:0045060, GO:0002821, GO:0030890, GO:2000343, GO:0032722, GO:0001961, GO:0002606, GO:0045893, GO:0070374, GO:0048146, GO:0010628, GO:0043123, GO:0045089, GO:0032755, GO:0032757, GO:0033674, GO:0060907, GO:2000448, GO:0043410, GO:0045657, GO:0090023, GO:0050731, GO:0031394, GO:0001934, GO:0045582, GO:0002830, GO:0046598, GO:0045059, GO:0001516, GO:0050821, GO:0070206, GO:0065003, GO:0034341, GO:0002286, CDD:cd00191, Gene3D:1.10.870.10, Gene3D:4.10.800.10, InterPro:IPR043530, InterPro:IPR015386, InterPro:IPR022339, InterPro:IPR011988, InterPro:IPR036613, InterPro:IPR000716, InterPro:IPR036857, Pfam:PF09307, Pfam:PF08831, Pfam:PF00086, PIRSF:PIRSF001992, PRINTS:PR01990, SMART:SM00211, SUPFAM:SSF48305, SUPFAM:SSF57610, PROSITE:PS00484, PROSITE:PS51162 |
| Sequence |
mddqrdlisnheqlpilgnrprepercsrgalytgvsvlvalllagqattayflyqqqgrldkltitsqnlqleslrmklpksakpvsqmrmatpllmrpmsmdnmllgpvknvtkygnmtqdhvmhlltrsgpleypqlkgtfpenlkhlknsmdgvnwkifeswmkqwllfemsknsleekkpteappkvltkcqeevshipavypgafrpkcdengnylplqchgstgycwcvfpngtevphtksrgrhncsepldmedlssglgvtrqelgqvtl |
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