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| Record Information |
| Record ID |
153 |
| Pubmed ID |
32186960 |
| SNP |
rs1800896 |
| Gene ID |
3586 |
| Protein ID |
P22301 |
| Vaccine Adverse Events |
|
| Vaccine |
inactivated Japanese encephalitis vaccine |
| Gene Name |
IL10 |
| Official Symbol |
interleukin 10 [Homo sapiens (human)] |
| Aliases |
CSIF, GVHDS, IL-10A, TGIF, IL10 |
| Other Designations |
interleukin-10; T-cell growth inhibitory factor; cytokine synthesis inhibitory factor |
| Chromosome |
1 |
| Location |
1q32.1 |
| Annotation |
Chromosome 1 NC_000001.11 (206767602..206772494, complement) |
| MIM |
124092 |
| DNA Sequence |
>NC_000001.11:206767602-206772494 Homo sapiens chromosome 1, GRCh38.p14 Primary Assembly
TGATGTGAATAAGATACATTTATTTATTCAAAATTAAAATCTGCTATGAAGACAGACAAACAATGTAACA
TTCCCAGAGGAATTGAATAAATTCTAGTTAAAACTGAGTTCTATTAGAACCAAATTTATTTTTATTTTTA
TTTTTTGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTACAGGGGCATGATATCAGCTCACTGCAAC
TTCCATCTCCTGGGTTCAAGCAATTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCGCGCC
ACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGACCAGGCTGGTTAGGA
ACTCCTGACCTCAAGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGC
GCCCGGCCTAGAACCAAATTTAGGTTGTTATAAATAACAAGCTGGCCACAGCTTTCAAGAATGAAGTGGT
TGGGGAATGAGGTTAGGGGAATCCCTCCGAGACACTGGAAGGTGAATTAATCATCAAAGGGGCTCCCTGG
TTTCTCTTCCTAAGAGTATTTGTAGCAGTTAGGAAGCCCCAAGCCCAGAGACAAGATAAATTAGAGGGAG
GTCAGGGAAAACAGCTCAACAGCTAGAAAGCGTGGTCAGGCTTGGAATGGAAGCTTCTGTTGGCTCCCCA
AAGAACATTTTTTTTCCTCCCTTATGTAACTTATAATTTATCTTAAAACACTCAAATACCATAGTGTGTC
ACCCTATGGAAACAGCTTAAAAACAGGTGAAAATAATAAATATTGAAAAAAATTATAATATTGGGCTTCT
TTCTAAATCGTTCACAGAGAAGCTCAGTAAATAAATAGAAATGGGGGTTGAGGTATCAGAGGTAATAAAT
ATTCTATAAGAGAGGTACAATAAGGTTTCTCAAGGGGCTGGGTCAGCTATCCCAGAGCCCCAGATCCGAT
TTTGGAGACCTCTAATTTATGTCCTAGAGTCTATAGAGTCGCCACCCTGATGTCTCAGTTTCGTATCTTC
ATTGTCATGTAGGCTTCTATGTAGTTGATGAAGATGTCAAACTCACTCATGGCTTTGTAGATGCCTTTCT
CTTGGAGCTGTGCAGAGAGATAAGAAACATACAGTTAAAATCCTTTCTGGGGACTAAATAGGCTCCCCTC
CCTCATGCTCATGGATGGGCATGACCTTGAGTGCAGAGGTTGCTTGTTCTCCCTCACGCTGGGAAGTAAA
CCAGAGGATAGGCCTAGCTGCCTTGGGAAAGGCTGTGCATTGACCTTCATCTCCTCCAGGCCTCCCCCTA
GCAAGGGGAGCATTCATTTTGCAAAGCACTGTCTTCAAAATGATGCCTTTTCAACAATTTTAAAGGTCAC
GTATTCACATGATGATTATGCAGAGTTTGATGAAAAGACATTAGAGGAAGCGCTTCGAAAGCAAGACGGT
GAGAGGAGAGGAGGGAGCCTTTTAAATGTCTGTGTTCTCCCACCAACACACTGAGCAGGCCCTGCCCTGC
CGCCCTGACCTACTATGAGAAATTCACACCCCCTGATGTTGGCACTCTGTGCAGTGTCTGTCCCCAGCCC
ACGAGGAGGACATAGGCCGCACGGTTTCTGGGAAATCAGACTGAAAAAGTTCACGCACAGTTGGAAGTGT
GAAACCCCATTTCGTTTGGGAACTGACATTCTCAGGCACCTCCGCAGGTGCGAAGGGCAGATGGAAAGCG
GGCTTGAACCAACTCCAGGTTAAGTGAGAATCCAGCTTCCTGCTCATTCTGAGTTCTGGGGAGTCTGGGC
TGAACCCCCAGGTGTATTTGTATGTGCACATTTATGTGCCAGCTTCCTGCACGTGTGGGTTCAGCCTAGA
TTCCCAACAAGCTACTTTCTGTACTTTCTGTTTCCTTTGTCACTCTCCCCAGCATGCAGCTCACTGTGTT
CACAGGCTGGCCGGCCAGCCTAACCCGCAAGCCTGCAAAGGCAGCGAGCAGTCATTTAGAAACCCCCAAA
GACACTTAACAGAAAACAAATACAATCAAGGCAGCAGCTCCTCACTGGCTGAGCAGGTCATACCATCTGT
CAGGTTCCCACACTCTCTCCAATGAAGAATGGGGCCTATTGAGTCCCCACCACCTTCCATGCTTTGGGGT
TGGGGAGTGGGCATGGGTTGTGCTCTGCAGACCCTCTCTGCCACCATCCAAGCTCACCTTATTAAAGGCA
TTCTTCACCTGCTCCACGGCCTTGCTCTTGTTTTCACAGGGAAGAAATCGATGCTGTGGAAGAAAAGAGA
AAGTGTTGGTGATCCTGGCTTCCAGCTCCATGTCCATCACACTTAGGGGACAAGCTGGTGGCATCATGAG
GAGGCCAGATTTATCCAAATGCCTTGCCTCACAGCTCCCAGAGAGAACTGAGCCCTGCTTCCATGGCCCT
GGGAGTTAAATGTATTTCTCCAGGACTCACTCCAAGATGTTTGCAAGGCTTGGATGACAACCCAGGTCTT
GGGATTCCTTCCTCCCCCAGAACTCTACAGTATCTCCTGCAGTGCTGAGCGAGGCATTCTTCAGCCTGTC
CTTTTCTGCCTCTCTCTCCTGTTCCTCCCCGTCAGTCACAGCCACCGAGGAACACTTCTAAGCATCTGAG
GAGGGAAGCTACTGGGACCAAACCCTTCACATAGCCTTGTCCTACAAATAGACACCAACTGATTTTCCAA
TATTGGTGACAGAACAGGGGAAACCATTAGTAGTGAGGGCATCATTTCAGTTGGAGAAATAAATTACCTG
GAGGAATTACTCATAGACACTAGCCTGGGGATGAATAGCCCCCTTGTCCCTTCTAAAATGCCAGGGGAAA
TCCTGTCAGTCAATTGGGCCCTTCTTAGAGCTTTGCTTTCAAAACATTGAGATTAAAAGAGGTGAATGAT
GTTTCCTCTGCTTGGGAACCTTAGCTCCCCGCCCAGGGTCTAGTTACAAAGAGGCAGTGGAGGCCTGACT
GAAGCTCTGGGCTCCTTTTATGAAGAGAGAGGGGAGTAGTTAATAACCCACAAATGACTCACAAATAACA
GGAAAGCTGTTTGCAAATTTCACATGTAAATGCCTAGCAGCCACCCCCAACGCCTGCTCAAAGAGAAATG
AGCAAGAGATCTGACTCCAGGAGTCTTTCCTCATTTACAGCTAGCTCTGCCAGTCTGTGTCTTTGCTGTG
TCTGTGGATGTGAGTGTCCCTGCTGGTCTGTAGGAGATGGTATTTTGGGGGCAGCTGCAAGGGAAAAAAC
TGATCTGCTACTTACACAGCGCCGTAGCCTCAGCCTGAGGGTCTTCAGGTTCTCCCCCAGGGAGTTCACA
TGCGCCTTGATGTCTGGGTCTTGGTTCTCAGCTTGGGGCATCACCTCCTCCAGGTAAAACTGGATCATCT
CAGACAAGGCTTGGCAACCCAGGTAACCCTAAGGGCAGGAGCCAAAGGTGAGTGAGAGATTGGCGGAGGT
GGCTGGGAGGAGGGGCTGCTGCAACTAGCTTAAGAGGACAGCTTGGTTCTAGCGATCCTCCTTCACCAGA
AGCCTCCCCGAAGGGACTGAGCCCTTTGTAAACCCTCTGGCTGCTGGATGTGCTGAGTTAACATCTTCCC
ACTTCTCCTTTTCAAAGCGAAGGAAACAAACCCAATTCCCTGCAATCAGGAAGCAGAGTCTCCCTTCCCT
TAATCATGCTGCACACTCCCCCAGCACCCCGCCCCTGCTCTCACCTTAAAGTCCTCCAGCAAGGACTCCT
TTAACAACAAGTTGTCCAGCTGATCCTTCATTTGCTGCAGGAAGAACAAAAGGAGAATGAACTTGAGGTT
TGGGGAAATAACTGAAATGCGGTCTTTTTGATGCCCTTTCATTTAGAGATTTTTTTTTTTAAATAAAATT
GGCTCTGGCCCAAAAAAATCAAAAGGGGAGTTTTAAAAACAGAGGATTCAACAGTGATGGGACCATCACT
TAAATCAGGTCCTCCTCCTCAGAGTCAAGTTATTTAAAAAATCTGGCCGATTTTGAAGGGAAAGCAGAAG
CTTGACTCAGTCCTGGTCTTCTTTCTGCGGAGCTACATTCGGCTTTAAGGGACACCTATGTCAACCCTTC
GGGGCCTTGAGCCCCCCTCATGTCCTGTTCTCTGCTTTTCTTTCTCCCCACTGTAGACATCCAGTTTAGC
TTGGAAAGATCCCAGGGATTAAGAAGCTCCTTCTAATGCAGGTTTCCCTCATGTAGAGTGCTTCCCTAAA
CCACTGGTCTTTCAGGTCTGGAAACGCTCTAAGCAGAGGCAATTTAAATTTCCCTGCTGCAAGGCATGGG
GAGCATCTTCACCTCGAATCAGACATTTCTTTACTTCTCCTAGCCAATAAAGTATAGAGCGCCAGCAGGA
TCTTATAAGTTTCTCAGCACGAGAGAGAACGCATTTACTTTATAAGGCAGGTTTCCTGCACATTTACTGT
ATCATCTGGCTTAGCTTAACTCACCAAACCCATGGCTTGATCTAGGATTCTCTTAAGAATTTAAGTTTGG
GGGAATAGGTGTTGGGGATGGAGGTGGAGGCGCAGGAGGAGGGTTCTTATAGTTCCAGGAGAATGTCTAG
TTCAGGCAGTCCCAGGAAGAGAGAAAGGACAGGAAGGAATCATACTCACAAAGAAAGTCTTCACTCTGCT
GAAGGCATCTCGGAGATCTCGAAGCATGTTAGGCAGGTTGCCTGGGAAGTGGGTGCAGCTGTTCTCAGAC
TGGGTGCCCTGGCCTGGGCTGGCCCTCACCCCAGTCAGGAGGACCAGGCAACAGAGCAGTGCTGAGCTGT
GCATGCCTTCTTTTGCAAGTCTGTCTTGTGGTTTGGTTTTGCAAGAGCAAGCCCCTGATGTGT
|
| Protein Name |
IL10_HUMAN |
| Length |
178 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-AUG-1991 |
| Definition |
RecName: Full=Interleukin-10; Short=IL-10; AltName: Full=Cytokine synthesis inhibitory factor; Short=CSIF; Flags: Precursor |
| Primary Accession |
P22301 |
| Accession Version |
P22301.1 |
| Other SeqIDs |
sp|P22301.1|IL10_HUMAN,gi|124292 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Mar 15, 2005 this sequence version replaced gi:106805.; [FUNCTION] Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity). {ECO:0000250|UniProtKB:P18893, ECO:0000269|PubMed:11564774, ECO:0000269|PubMed:16982608, ECO:0000269|PubMed:18025162, ECO:0000269|PubMed:1940799, ECO:0000269|PubMed:7512027, ECO:0000269|PubMed:8144879}.; [SUBUNIT] Homodimer (PubMed:11485736, PubMed:15837194). Interacts with IL10RA and IL10RB (PubMed:16982608). {ECO:0000269|PubMed:11485736, ECO:0000269|PubMed:15837194, ECO:0000269|PubMed:16982608}.; [INTERACTION] P22301; O76003: GLRX3; NbExp=3; IntAct=EBI-1031632, EBI-374781; P22301; Q13651: IL10RA; NbExp=9; IntAct=EBI-1031632, EBI-1031656; P22301; Q08334: IL10RB; NbExp=2; IntAct=EBI-1031632, EBI-11175900; P22301; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-1031632, EBI-11749135; P22301; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-1031632, EBI-10171774; P22301; Q9BYQ7: KRTAP4-1; NbExp=3; IntAct=EBI-1031632, EBI-34579671; P22301; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-1031632, EBI-22310682; P22301; P25490: YY1; NbExp=3; IntAct=EBI-1031632, EBI-765538.; [SUBCELLULAR LOCATION] Secreted.; [TISSUE SPECIFICITY] Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. {ECO:0000269|PubMed:1940799, ECO:0000269|PubMed:7512027}.; [POLYMORPHISM] A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS) [MIM:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease. {ECO:0000269|PubMed:14657427}.; [SIMILARITY] Belongs to the IL-10 family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Interleukin-10 entry; URL='https://en.wikipedia.org/wiki/Interleukin_10'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/il10/'. |
| Source Db |
UniProtKB: locus IL10_HUMAN, accession P22301;; class: standard.; created: Aug 1, 1991.; sequence updated: Aug 1, 1991.; annotation updated: Oct 12, 2022.; xrefs: M57627.1, AAA63207.1, U16720.1, AAA80104.1, AY029171.1, AAK38162.1, AF418271.1, AAL06594.1, A38580, NP_000563.1, 1ILK_A, 1INR_A, 1J7V_L, 1LK3_A, 1LK3_B, 1Y6K_L, 2H24_A, 2ILK_A, 6X93_A, 6X93_D; xrefs (non-sequence databases): CCDS:CCDS1467.1, PDBsum:1ILK, PDBsum:1INR, PDBsum:1J7V, PDBsum:1LK3, PDBsum:1Y6K, PDBsum:2H24, PDBsum:2ILK, PDBsum:6X93, AlphaFoldDB:P22301, SMR:P22301, BioGRID:109800, CORUM:P22301, DIP:DIP-3511N, IntAct:P22301, MINT:P22301, STRING:9606.ENSP00000412237, BindingDB:P22301, ChEMBL:CHEMBL3712920, DrugBank:DB05744, DrugBank:DB05771, GlyGen:P22301, BioMuta:IL10, DMDM:124292, MassIVE:P22301, PaxDb:P22301, PeptideAtlas:P22301, PRIDE:P22301, ProteomicsDB:53970, ABCD:P22301, Antibodypedia:3407, DNASU:3586, Ensembl:ENST00000423557.1, Ensembl:ENSP00000412237.1, Ensembl:ENSG00000136634.7, GeneID:3586, KEGG:hsa:3586, MANE-Select:ENST00000423557.1, CTD:3586, DisGeNET:3586, GeneCards:IL10, HGNC:5962, HPA:ENSG00000136634, MalaCards:IL10, MIM:124092, MIM:614395, neXtProt:NX_P22301, OpenTargets:ENSG00000136634, Orphanet:117, Orphanet:238569, Orphanet:536, PharmGKB:PA29778, VEuPathDB:HostDB:ENSG00000136634, eggNOG:ENOG502S22U, GeneTree:ENSGT00950000183124, HOGENOM:CLU_127747_0_0_1, InParanoid:P22301, OMA:MIQFYLV, OrthoDB:651627at2759, PhylomeDB:P22301, TreeFam:TF333253, PathwayCommons:P22301, Reactome:R-HSA-6783783, Reactome:R-HSA-6785807, Reactome:R-HSA-8950505, Reactome:R-HSA-9662834, Reactome:R-HSA-9664323, SignaLink:P22301, SIGNOR:P22301, BioGRID-ORCS:3586, ChiTaRS:IL10, EvolutionaryTrace:P22301, GeneWiki:Interleukin_10, GenomeRNAi:3586, Pharos:P22301, PRO:PR:P22301, Proteomes:UP000005640, RNAct:P22301, Bgee:ENSG00000136634, ExpressionAtlas:P22301, Genevisible:P22301, GO:0005576, GO:0005615, GO:0005125, GO:0008083, GO:0005141, GO:0046983, GO:0007568, GO:0030183, GO:0042100, GO:0060670, GO:0071392, GO:0035729, GO:0071222, GO:0002439, GO:0007253, GO:0042742, GO:0042832, GO:0072577, GO:0030097, GO:0030595, GO:0097421, GO:0043066, GO:0010507, GO:0030889, GO:0008285, GO:0071650, GO:0002875, GO:0060302, GO:0001818, GO:0002719, GO:0034115, GO:1903208, GO:0050728, GO:0032687, GO:0032689, GO:0032692, GO:0032695, GO:0032701, GO:0032715, GO:0032717, GO:0051045, GO:0045347, GO:0045930, GO:0030886, GO:0043524, GO:0045019, GO:1904057, GO:0042130, GO:0032720, GO:1904706, GO:0002904, GO:0045787, GO:0001819, GO:0051091, GO:0045893, GO:0001938, GO:0034116, GO:0002639, GO:0043032, GO:0045348, GO:1902895, GO:1900100, GO:0046427, GO:2000273, GO:1903672, GO:0045944, GO:1904707, GO:0010468, GO:0045191, GO:1903034, GO:0050807, GO:0014823, GO:0034465, GO:0051384, GO:0014854, GO:0032868, GO:0002237, GO:0009410, GO:0042092, Gene3D:1.20.1250.10, InterPro:IPR009079, InterPro:IPR000098, InterPro:IPR020443, InterPro:IPR020423, Pfam:PF00726, PRINTS:PR01294, SMART:SM00188, SUPFAM:SSF47266, PROSITE:PS00520 |
| Sequence |
mhssallcclvlltgvraspgqgtqsenscthfpgnlpnmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqalsemiqfyleevmpqaenqdpdikahvnslgenlktlrlrlrrchrflpcenkskaveqvknafnklqekgiykamsefdifinyieaymtmkirn |
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