|
|
| Record Information |
| Record ID |
150 |
| Pubmed ID |
32186960 |
| SNP |
rs2227284 |
| Gene ID |
3565 |
| Protein ID |
P05112 |
| Vaccine Adverse Events |
|
| Vaccine |
inactivated Japanese encephalitis vaccine |
| Gene Name |
IL4 |
| Official Symbol |
interleukin 4 [Homo sapiens (human)] |
| Aliases |
BCGF-1, BCGF1, BSF-1, BSF1, IL-4 |
| Other Designations |
interleukin-4; B cell growth factor 1; B_cell stimulatory factor 1; binetrakin; lymphocyte stimulatory factor 1; pitrakinra |
| Chromosome |
5 |
| Location |
5q31.1 |
| Annotation |
Chromosome 5 NC_000005.10 (132673989..132682678) |
| MIM |
147780 |
| DNA Sequence |
>NC_000005.10:132673989-132682678 Homo sapiens chromosome 5, GRCh38.p14 Primary Assembly
ATCGTTAGCTTCTCCTGATAAACTAATTGCCTCACATTGTCACTGCAAATCGACACCTATTAATGGGTCT
CACCTCCCAACTGCTTCCCCCTCTGTTCTTCCTGCTAGCATGTGCCGGCAACTTTGTCCACGGACACAAG
TGCGATATCACCTTACAGGAGATCATCAAAACTTTGAACAGCCTCACAGAGCAGAAGGTGAGTACCTATC
TGGCACCATCTCTCCAGATGTTCTGGTGATGCTCTCAGTATTTCTAGGCATGAAAACGTTAACAGCTGCT
AGAGAAGTTGGAACTGGTGGTTGGTGGCAGTCCAGGGCACACAGCGAGGCTTCTCCCCTGCCACTCTTTT
TTCTGAGGGTTTGTAGGAAGTTTCCTCAGTTGGAGGGAGTGAGAGCTGCTCATCAAGGACTTCTCTGTCC
GGTTGGAGGTTAACTCTGTCTCTTGCTCTCTCATTTCTGCCTGGACCAAGACTCTGTGCACCGAGTTGAC
CGTAACAGACATCTTTGCTGCCTCCAAGGTAAGAAGCCGTCCCACGGTCTGTTTTAGCAAATGGGGAGAT
CCATCCCCAAATGTCTGAACAAGAAACTTGTCTAATGGAAAACGAGCGGGCCCAAATTAACTCTAAGGTG
TTAGATGTTTTCAAAGAACGAGAAGTCTGATCTTTACTCTTAAGCATGTTTTGGTCTTTCTGGTTTCACT
TGATTTAGAAGACATGTAATAGAAAGCTTACATGCTGTAGTCCTGACTCAGATCCTGGTCAAAGAAAAGC
CCTCTTGGGTTTTACTTAGCTTTGGCATAGTGCCTGGAACGTAGGAGGCACTCAATAAATGCCTGTTGAA
TGAGAGAATTTTTCTGGCCCATACATTTCTGAAAAACCAAATACTCTCACAGAAACAGATATTGAGATGA
CAGGTTGAGGGAGCTTTCATTTTGTCTAAGAGACTTCCTATGGCAACAGAAAAGGTATCGCCAGAGCCCC
TCCTCTTCCACAGCCTGGCCACCTAACAGCCCTCTGGGTTCCGGGGCTGGCCGTCCAGAGCTCCTCAGCT
TGCTCTGGCCGGCCGAACTCCCCTCCAGCTCGGTCTGGAACCATCCTGCTGGGCAGCGTCCAGCACATCC
CTGCTTCGGGCTGCCTGGGCACCTCGCCTCTCTGCCTCCTGTGCTGCCTCACCCCCACCCCTCTATCTGT
AGTGGGAGGAGATAGATTTGACAGCTGATAGTGCATTTTCTCTGACAAACACATGACTACAGCCGTATCA
ATAGTTTTGTGCATTTCAGTTCCTGTTTTCATGGAAACACACGGCTGAGAATGAAAGCCCCAAAGCCTCA
ATTTCACAGTGGTCTCCTAACTACCTGCTTTCCATGCAAACTAGGGAGATGATATGGCCAGGAGTGAAGC
CCTGTGTGTTGGGCAGGGTCACACTCCAGCACCCAGACCATAGAACAGGGCCCATCCTGCTTCATGAGGG
AAACTGCTCTTCGGGCCTTTAGCTGGACTATCTCATTTCATTAGTTATCCCGGGAGTCCGATACAGGATG
AGATTCTGAAGGGCAAATACACACTTTTTTTTTTTTTTGAGATAGGGTCTTGTTCTGTCACCCAGGCTGG
AGTGCAGTGGTGCGATTTCAGCTCATAGCAGCCTCCACCTCCCAGGCTCAAGCTATCTTCCTACCTCAGC
CTCCCAAGTAGCCGGGACGACAGGTGTGCACCACCACGCCTGGCTAATTTTTGTATTTTTTTGTAGAGAT
GGAGTCTTGCCATTTTGCCCAGGCTTGTCTCGAACTTCTGGGCTCAAGCAATCCGTCCACCTCGGCCTCT
CAAAGTGCTGGGATTAGCCACTGCACCTGGGCAACAGTTTATGTGTGTGTGTGTGTGTGTGTGTGTGTGT
ATATATGTGTGTGTGTATATATATGTGTGTATGTATATATGTGTATGTATATGTGTGTGTGTGTGTGTGT
GTGTGTGTATAAAATCTCCAAGTCCATCCAACCGAGATGGCTCCTACTAGAAGCCAAGAGTCCACCGGGT
TGAGCACTGGGTCTCTGGAGGCCTGTGGCACTGCTGAGAAGGCTCTAACAAAGCCAAGGGAAGGGCCACC
TCACTAGAAGCCAGGCCTGGAGGAAGGGTGAGGGCTGAGGGCCTGGAGGTAAGACTGCCTGTGGTTTTAG
ACCCAGCTCTGCCACTGACTAGCTGTGTGGCTGGCCTTCAGCACATCTTCACACCTCTCTGCACCTCAGT
TTCCACATGTGAAGATATGAAAGTGATTCTGAAGGTGATTGCAAGGTTGATTGGAATCCAGCTCTTGAGT
TAGTGCAAAGTGTTATTGTGAGATGATATAACCACGATTAAAAGCAAGAACAGGTGCAGAGAAGCGATGA
TTCTAAGAAGGAGGGGACCGGGTTGGAAAGGATCAAACCATCCAGGATGCCGAGTCTGGGGCAATCCATC
TGGGCTGTTTCTGGAAGACCCCCGGGTGCAGGCCAGGACACTGCTGCCCTCCCGTCCTTAACTCCCCTCT
TCACTCAGTCCTCACTCACCTCCCTCTCACACACACAAACATCTCCTAGAATAATCCCCACTGCCTGCCT
TCACTCTTACCCGTCTCATTTGCCTCCCCTGAACTTCATCCTCCTGGAGTTCACGATCTCACTCTTCACT
CTTTTCTTCCCCTCGAAGATTCAGCACTGCTTACTTACATGTTAAGATATTTCAGAACAGTGAAATGTTG
CTATTTTCAAAAACCTACAAAGGTGGTATGCAGAGGAAAAGGTACTTCTTTGTGTTCCCAAAGAAAACAT
CTTTCCAAAATCCAGCCTATTGATTTTATTTCTTCGGGGGAACAAGAATTTTAGTATCTCTAAGTTGGGT
AGCATTCTACTCTTGGCAGTTGCTGGAAAGAAGGCACTGGTCTAGGTCCTGGGCTTCACAGGTAACACCT
GTCAGGGTGTCTATGAAGTCAAGGCTGTCTGAGGAACAGCAAAGTGGGAAGAAGCAAGCTGGCTGGCTGA
TGAAGGGTTTCTTGGGTGGACAAGTAGTTGGAGCTATTTCCTATTTACCAAAGAGAGCTAAAGTTCATAA
TTCTACAGAGAGTTCCATAATGAACCTCAAATACCTCTGTTTTTTGAAGGAGTTTCTCATATACAGCACT
AGCTGACTATCCTGGGCAGGATGGGAGATAATGAATGCAGTGCCAATCGGGCTGGATTTATATGGTCCTC
AGTGAGGCTGGTCAAGAACCGAGTTAGAACTCTCACAGAGTCACTGCCACAGAAGAAATCTCCCAAGTGG
CTGTTTCCTGACATTCCCGGGAGGGACAGGCCTCCTTCTGAGTCACTCCCTAAGCAGTTCTGAACTGTGA
GGTCAGCCAGGCTGTCCAAGTGCACTCCCTGAGCCACTGGCAGACACACTCAGCAGCCAGAGCTAGACAG
GCAGGTGGTAGGAGTCCAGGGCCACGGCAGGGATGGAGTGTCGCCCCCTCGCTGCGATACCAGAGCAACT
AAAACGTTAAGGCCTTGCACTAAAGCTGCCCTTAGGATGCATTCTTTTAAAGTTTTTCCATTTAATGCAG
ACTCTTTTCAATTCTTATTTTATCCTTGTTTCCTTTAGAAAGTCCTTTCAAAAATATCTTTAGAGGGTTT
TTTCCTATACTATGTGGCCATATACGGGTCAAAATTAAGTTTAATTTCCAGGCTCCAAGCCAGCGTTTCA
GAAAAATCTCACCAAGGTTTGTGGTAAAAGAAGCAAAGGGCTGACTTTTTGGTTTTCTTGAATCTCACTG
TTCCCTCTGCAGCAGCATGCATGTCTGCCCACCTCCAGACACACAGGCACCATCTGCCGCCCCCCATCAG
CCCGTGTCCCTTCCACCTCGACTCGCCTACAAAGCCCAGAGAGGTCTGTTTCTTGGCCCCCAGAGCCCAA
AGATACTGACACACTCTTACATTTCCAACTAGAATCAGGAACGAGGAGTGACTCTCAGTCAGTTCATTAA
GTAAATGTCTTTCTAACCGCTCTGCCCATGGGACATCACGCCCCACAGGGGAAAGGGGAAGCTTCTGTAG
CCTGGGATTCTGGTGCCTCAGTCTGGGTCTAGACTTTCCTGAAAAAACGTTAAAATATGAACTGCATTCC
TAGAATTTAGCCTACATAAATAAGAGATGAACACAAAGATTTCTATAGTTTACTCACTGCCGCTTATTTA
CAGAAGCAAAAATCTGCCACGATAGGGGCCTGACAAATGACAGTACCACTGTGCAATGCGTTTCTACGCA
GCTCTCAATCCCATGTTCTCTAATACCACCGAAGGGCTTAGGAAATGCTTATGGTATATGTAAAGAGTAA
AGAAGTTACAAAACAGTATCAACAGTTGACCCCTATTTTAAAAAGTATTTTTAAAAGTGTGACGATATTT
ACCAAAATATTAACAGCAATAGTTACCTCTGGCTGGTGGGATGAGTGAATGTATTTTTGTTGAATATATG
TTACCTTTATAGTAAATATATGTTATCTTGATCATCAGAAAAAAAAATATGTAAGAACTTGAAAGCTGCT
TGGACAGCGCTGCTGATAGAAACCCCTGAGCATCTTGTCACTGTTCTTCTGATTCAGAGGGTCTGGGTGG
GGCAGGGGTGGTCTGAGATTCTGTATTTCTAAGAAGCTCCCAGTGATGTCCATGCTGCTGGTCCATGGAC
CACACTTTGAGTATCAAGGGACCAGAGCATGTCGGGGGAGAGGCTGGGGATAGCTTTCTTTATCTGAACT
GGATAAAGGAACTGGGCTCAAGCTAAGAACCCTCTCCAGGTTCTGCATCTTTGTTCTTCAGTGAAAAATG
AGAGGACACACCAGGCCAGGTTCAGACTGAGACACAATCCCTCTCCTGGGTTCCCAATGACTTGTCTCTT
GTCCATTCCCTTCTCTAAGGCTAAGGGCCCCCAGGAAGAGCCATGTGGCCAGACCCTCACAGTTGCTGGC
ATTCCAAGGAGATTCTCACTCCGCATCATTTGGGGCCAAAAGGCCCCTTACAGAAGCTCTGCCCAAGGCT
CAGATCAATGGCACCTGCTCCCAGAGCCTCCTCTGATCTCCCAGGACACCTTTCCCTGATCTGTGCACTT
ATCTCTTGCTGCCTGGCAAAATGTCTTAGCTCCTCACTTGGGCCATGTGCTGCTCTCCTCTCCCATGGGG
AGAGCCACACGGAGAGTGCTGGCCAAAGCAGCAGAGTTCAGGCCAAAGGATGTGCACTCATTTATTCAAC
AGGCATGCAGGATTTCCAGGGAAAGCTGGATTTTAAAACCTCTGGGAACAAGAGCAGAACCTGACTGAGA
GCTCATGTGGGCACTTTTCATAGCAGAATAGCTCATGAGGTATAGAGACACGGACGCAGAACGTGGGCTG
TAGCGACAGATGGTCCTGCATTCTAGTCCCCACTGTGCCTTTTCCTCATGGGATGACTTTATTCAGGTAC
CCTTTCGGCAAAATCCTCCAAGAGAAAGGAAACTGGGAGGTTCTGGGGAGAAGGCTGCTGCGTTTGCAAT
TGGGAGAGGTTGTTGACAGAGGTTTATGTCTGTGGCAAGCAGCCTTCCTTCAGTGGAATACTTGAAGACA
GGTCTGTAGTTGAGCAAACTCACCTCCATTTGTCCTCCTGGAAAGAAGAAATCAAGAGGAAAAATCTCTC
TCCCATCCTCCAAATGGAGCTGGCACATTGCTATCTGTGGCATTTGTCTTTCCAGAACACAACTGAGAAG
GAAACCTTCTGCAGGGCTGCGACTGTGCTCCGGCAGTTCTACAGCCACCATGAGAAGGACACTCGCTGCC
TGGGTGCGACTGCACAGCAGTTCCACAGGCACAAGCAGCTGATCCGATTCCTGAAACGGCTCGACAGGAA
CCTCTGGGGCCTGGCGGGCTTGGTAAGCTGCACTGTATTCCTGGCAAGCCGGCCGCGTGGCTCCTGGTGG
ACAGCAGCCTCACTTCTAAACACTCCTTAGGAGCTGCAGCACCCTTGGTCAACCCATTCATTCATTCACT
CATTCAATAAGTATTTGCTGAAGTTCCACAAGTGCTGGGTGTGGTTCTAGGTGCTGAGGACGTGTCACTA
AAGACACGCAGGCCGAGTCCCTGTTCTCATGGAATGTTCTAATGGGAGAGTTAGAAAAACAAACATGTAA
AATGATGGCCAGCAGTGATACGTGCTACAAAGAAAAACATAGAAATAAAGAACATAAGAGTCATGGGGGA
GGGGGCTGACTTAGGAGCTGGTGACATTATCTGAGCAGATATTTGAATTGAGGGAGCAGGCCACATGACT
AACTAGGGAGACCATTCCAGGCAGAAGGAGGAGGTATGCAAAGGCCTTAGGATGGAAATGAACTAACTTC
CTGTATTTAAAGACCAGTAGGAAGGCCAGTGTGGCTGGATCAGAGTGAGTGAGGGGTAGTTTCCAGGACA
GCAGATCACACAAGGCCTTTAGATTCCACCACGAGTATGGCAGGGAACACCTGCAGAGCTTTGGGCAGGA
CAAAGACTGTACAATCTGATTTACGTGATTTAAAAGGGTCAGTCTGGCTACTGTGTGGTAAATAGGCTGA
AAGGGGGAAAGCATAGAAGCAAGATGGCCTGTTGGGAGGCTACCACAGTAAACCAGGCTAGAGATGATGG
TGGCGTGGACAGAATGAAGCAAGATGGCCTGTTGGGAGGCTACCACAGTAAACCAGGCTAGAGACGATGG
TGGCGTGGACAGAATGAAGCAAGATGGCCTGTTGGGAGGCTACCACAGTAAACCAGGCTAGAGATGATGG
TGGCGTGGACAGAATGGGAGCAGTTGAGGTGAACAGATTTGGGATATGACTAAAAATAAAACCAGAAGGA
TTTGCTGACAGATCGGTTGTAGGGGGTAAGATACAGGGGAGGAAAAGATGACCTCTTTGTTCCTGCCCAA
ACCCCTCTGGCGATGGTCAGTACTGTTTACAGAGAGATGAAAGACTGGCGGCAAGGCAGGGCTGGAGGTT
CAGCAGAAGATCAAGAGTTCAATTTTGTACATCGTACATGTAAGGTGGCTCTTGGATAGCCAAGTGAAGG
TGTTGAGAAGATGGTTAGAAAAGTCTGGAACTTAGGGGAGAGGTCAGAACTTGCAATACAAAAAGGAGAG
TCCTTAGATAGATACTGCTGAAAATCTGAATGACAGAAAGGGAGAGATCAAAGGACTGAGCCTGAGATCA
ACACATGGAGGTCAGGAGAGGAGGATCCAGCCAAGGGGCCTGAGGAGGAGTGACCAGTGAGGCAGGAGAA
CACTGGAGAGTGGGCGGTACCCCAGGAAGCCGTTGAGGACACTCAAGGAGGGAGGGTTGACTGTGTCAAA
TGTACTGAAAGGACAGGTCAGGTGAGGACCAAGAAAGGCCCCTGGGTTTGGCTGATGGAGGCCATGGGTG
AGGCTGATGTAAATGGAGAGGCAGGAAGGAAAGCCCAGCTGGAGTGGGCTCACCGAGGATAGGGTGGCGA
GAGGAGACAAAGAAGGAACAGTGAGGGCAGAACACTCTTTGAAGATGTTTAGCTATAAGGCTGCAGAGAA
ACTGACCCACAGCTGCAGGGTGGTTATGGAGTGAGGGAAGCTCTTTTAAGGTTGGGGGTATACCCAGCAT
GTTAATGCACCTGGGGGAATGGTCCAGTGGAGCAGGAAGAACTGAAGAGAGCAGAAAGAGGAAGAATCAT
TAGGGGGCAGAAGTCCTTGTAGCCCAGAGTGGATGTTATCTAATATCGAGTGGAGGAATTAATTGGCTTT
AGAGGAGAACAAGGACATGTATCCCCTCTCTGGGCCTATCACCTTGTAGACAATGGGATAGGTCATGGGA
TAGGAACTTGGCACAACACATGTTCTCTCTTTTAATTCTCTCCATTATCTTATGAAGCAGGCAAGTAGGC
AAACAATTGTCCCAACTTTACAAAAGAAACTGAAGCTTTTATAAATTAAGTAGTACATCCTAAGCAATAC
AATTAATAAATGGTAGAGCTGAGATTCAAACTGAAGCAGTGGCCTGGGGGTAGCATCTGGAATCCTTCCC
ACCTTTAGGGCTGCTGTGCTGCGGTGCTGCTGTTTAATGGCACAGGAGGGCCACATGACTGAATCTCTCT
CAGCAGTCCAGGCAGTCATGCAGAAGGCCCAGTAGAGCACCGGGCAGGTCTGAGCCAGCATCTTCAAGTT
CCACCCTCTGAGCAAGCACCTAGCTGTGACACACCTCTCCAGAGACTGCACTCCCCCCCGCGCCACCCAC
CCCAAAAGCAGATAGGTAATGGTATACAGTAACCATTTCTAGAAGTGTAAGTAGTATGCACCCAAAATAG
GCAAAACCTGCTGGCCTAGTGATAGAGACAACTCCCAGTCAGGCTAGACTGGAGGCCTTGGTTTTATAAG
TGTTCAGGTGACAAGTGCCACAGTAGGCTTGATCAAGTAGACAGGCAGGCAAGACAAATGCTTACCAATG
CAAGCTAATGAAATGTTTCTTTTGCAGAATTCCTGTCCTGTGAAGGAAGCCAACCAGAGTACGTTGGAAA
ACTTCTTGGAAAGGCTAAAGACGATCATGAGAGAGAAATATTCAAAGTGTTCGAGCTGAATATTTTAATT
TATGAGTTTTTGATAGCTTTATTTTTTAAGTATTTATATATTTATAACTCATCATAAAATAAAGTATATA
TAGAATCTAA
|
| Protein Name |
IL4_HUMAN |
| Length |
153 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
13-AUG-1987 |
| Definition |
RecName: Full=Interleukin-4; Short=IL-4; AltName: Full=B-cell stimulatory factor 1; Short=BSF-1; AltName: Full=Binetrakin; AltName: Full=Lymphocyte stimulatory factor 1; AltName: Full=Pitrakinra; Flags: Precursor |
| Primary Accession |
P05112 |
| Accession Version |
P05112.1 |
| Other SeqIDs |
sp|P05112.1|IL4_HUMAN,gi|124337 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Nov 16, 2013 this sequence version replaced gi:74737031, gi:88111.; [FUNCTION] Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:3016727, PubMed:1993171). Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:1993171). Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (PubMed:2521231). Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (By similarity). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells (PubMed:10219247, PubMed:11526337, PubMed:18243101). Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 (PubMed:7721895). {ECO:0000250|UniProtKB:P07750, ECO:0000269|PubMed:10219247, ECO:0000269|PubMed:11526337, ECO:0000269|PubMed:18243101}.; [SUBUNIT] Interacts with IL4R (PubMed:10219247, PubMed:11526337). Interacts with IL13RA1 (PubMed:18243101). {ECO:0000269|PubMed:10219247, ECO:0000269|PubMed:11526337}.; [INTERACTION] P05112; P78552: IL13RA1; NbExp=3; IntAct=EBI-367025, EBI-1391535; P05112; P24394: IL4R; NbExp=7; IntAct=EBI-367025, EBI-367009.; [SUBCELLULAR LOCATION] Secreted.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P05112-1; Sequence=Displayed; Name=2; Synonyms=Short, IL-4delta2; IsoId=P05112-2; Sequence=VSP_002672.; [DISEASE] Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269|PubMed:14681304}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; [SIMILARITY] Belongs to the IL-4/IL-13 family. {ECO:0000305}.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/il4/'. |
| Source Db |
UniProtKB: locus IL4_HUMAN, accession P05112;; class: standard.; extra accessions:Q14630,Q6NZ77; created: Aug 13, 1987.; sequence updated: Aug 13, 1987.; annotation updated: Oct 12, 2022.; xrefs: M13982.1, AAA59149.1, M23442.1, AAA59150.1, X81851.1, CAA57444.1, AF395008.1, AAK71324.1, BC066277.1, AAH66277.1, BC067514.1, AAH67514.1, BC070123.1, AAH70123.1, X06750.1, CAA29925.1, A25946, NP_000580.1, NP_758858.1, 1BBN_A, 1BCN_A, 1CYL_A, 1HIJ_A, 1HIK_A, 1HZI_A, 1IAR_A, 1ITI_A, 1ITL_A, 1ITM_A, 1RCB_A, 2B8U_A, 2B8X_A, 2B8Y_A, 2B8Z_A, 2B90_A, 2B91_A, 2CYK_A, 2D48_A, 2INT_A, 3BPL_A, 3BPN_A, 3QB7_A, 3QB7_B, 4YDY_I, 4YDY_J, 5FHX_A, 6OEL_A; xrefs (non-sequence databases): CCDS:CCDS4158.1, CCDS:CCDS4159.1, PDBsum:1BBN, PDBsum:1BCN, PDBsum:1CYL, PDBsum:1HIJ, PDBsum:1HIK, PDBsum:1HZI, PDBsum:1IAR, PDBsum:1ITI, PDBsum:1ITL, PDBsum:1ITM, PDBsum:1RCB, PDBsum:2B8U, PDBsum:2B8X, PDBsum:2B8Y, PDBsum:2B8Z, PDBsum:2B90, PDBsum:2B91, PDBsum:2CYK, PDBsum:2D48, PDBsum:2INT, PDBsum:3BPL, PDBsum:3BPN, PDBsum:3QB7, PDBsum:4YDY, PDBsum:5FHX, PDBsum:6OEL, AlphaFoldDB:P05112, BMRB:P05112, SMR:P05112, BioGRID:109779, CORUM:P05112, DIP:DIP-3222N, IntAct:P05112, MINT:P05112, STRING:9606.ENSP00000231449, ChEMBL:CHEMBL3712894, DrugBank:DB06560, DrugCentral:P05112, GlyGen:P05112, iPTMnet:P05112, PhosphoSitePlus:P05112, BioMuta:IL4, DMDM:124337, MassIVE:P05112, PaxDb:P05112, PeptideAtlas:P05112, PRIDE:P05112, ProteomicsDB:51797, ProteomicsDB:51798, ABCD:P05112, Antibodypedia:14502, DNASU:3565, Ensembl:ENST00000231449.7, Ensembl:ENSP00000231449.2, Ensembl:ENSG00000113520.11, Ensembl:ENST00000350025.2, Ensembl:ENSP00000325190.3, GeneID:3565, KEGG:hsa:3565, MANE-Select:ENST00000231449.7, UCSC:uc003kxk.3, CTD:3565, DisGeNET:3565, GeneCards:IL4, HGNC:6014, HPA:ENSG00000113520, MIM:147780, MIM:601367, neXtProt:NX_P05112, OpenTargets:ENSG00000113520, PharmGKB:PA197, VEuPathDB:HostDB:ENSG00000113520, eggNOG:KOG3886, GeneTree:ENSGT00390000013108, HOGENOM:CLU_154691_0_0_1, InParanoid:P05112, OMA:SCMELTV, PhylomeDB:P05112, TreeFam:TF336383, PathwayCommons:P05112, Reactome:R-HSA-6785807, Reactome:R-HSA-9012546, SignaLink:P05112, SIGNOR:P05112, BioGRID-ORCS:3565, EvolutionaryTrace:P05112, GeneWiki:Interleukin_4, GenomeRNAi:3565, Pharos:P05112, PRO:PR:P05112, Proteomes:UP000005640, RNAct:P05112, Bgee:ENSG00000113520, ExpressionAtlas:P05112, Genevisible:P05112, GO:0005576, GO:0005615, GO:0005125, GO:0008083, GO:0005136, GO:0042976, GO:0031296, GO:0030183, GO:0008203, GO:0097028, GO:0097192, GO:0006955, GO:0002227, GO:0042116, GO:0001774, GO:0043011, GO:0002674, GO:0043066, GO:1903845, GO:0002677, GO:1903660, GO:0045892, GO:2000352, GO:0010633, GO:2001237, GO:0050728, GO:0043031, GO:0150079, GO:0045671, GO:2000320, GO:0000122, GO:0032720, GO:0150076, GO:1900223, GO:2001171, GO:0030890, GO:0030335, GO:0008284, GO:1901857, GO:0120162, GO:0002230, GO:0045893, GO:2000424, GO:0010628, GO:0032733, GO:0032736, GO:0048295, GO:0048304, GO:0016239, GO:0043306, GO:0045348, GO:0071677, GO:1901741, GO:0048260, GO:0045582, GO:0042102, GO:2000553, GO:0045944, GO:0042531, GO:0050776, GO:0045191, GO:0042325, GO:0042110, GO:0045064, GO:0042092, Gene3D:1.20.1250.10, InterPro:IPR009079, InterPro:IPR002354, InterPro:IPR001325, InterPro:IPR018096, PANTHER:PTHR47401, Pfam:PF00727, PIRSF:PIRSF001941, PRINTS:PR00431, SMART:SM00190, SUPFAM:SSF47266, PROSITE:PS00838 |
| Sequence |
mgltsqllpplffllacagnfvhghkcditlqeiiktlnslteqktlcteltvtdifaaskntteketfcraatvlrqfyshhekdtrclgataqqfhrhkqlirflkrldrnlwglaglnscpvkeanqstlenflerlktimrekyskcss |
|
