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| Record Information |
| Record ID |
15 |
| Pubmed ID |
34835092 |
| SNP |
|
| Gene ID |
1440 |
| Protein ID |
P09919 |
| Vaccine Adverse Events |
varicella vaccine meningitis |
| Vaccine |
varicella vaccination |
| Gene Name |
CSF3 |
| Official Symbol |
colony stimulating factor 3 [Homo sapiens (human)] |
| Aliases |
C17orf33OS, GCSF, CSF3 |
| Other Designations |
granulocyte colony-stimulating factor; filgrastim; granulocyte-colony stimulating factor; lenograstim; pluripoietin |
| Chromosome |
17 |
| Location |
17q21.1 |
| Annotation |
Chromosome 17 NC_000017.11 (40015440..40017813) |
| MIM |
138970 |
| DNA Sequence |
>NC_000017.11:40015440-40017813 Homo sapiens chromosome 17, GRCh38.p14 Primary Assembly
AGCCCGGAGCCTGCAGCCCAGCCCCACCCAGACCCATGGCTGGACCTGCCACCCAGAGCCCCATGAAGCT
GATGGGTGAGTGTCTTGGCCCAGGATGGGAGAGCCGCCTGCCCTGGCATGGGAGGGAGGCTGGTGTGACA
GAGGGGCTGGGGATCCCCGTTCTGGGAATGGGGATTAAAGGCACCCAGTGTCCCCGAGAGGGCCTCAGGT
GGTAGGGAACAGCATGTCTCCTGAGCCCGCTCTGTCCCCAGCCCTGCAGCTGCTGCTGTGGCACAGTGCA
CTCTGGACAGTGCAGGAAGCCACCCCCCTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGT
GCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGGTGAGTGAGGTGGG
TGAGAGGGCTGTGGAGGGAAGCCCGGTGGGGAGAGCTAAGGGGGATGGAACTGCAGGGCCAACATCCTCT
GGAAGGGACGTGGGAGAATATTAGGAGCAGTGGAGCTGGGGAAGGCTGGGAAGGGACTTGGGGAGGAGGA
CCTTGGTGGGGACAGTGCTCGGGAGGGCTGGCTGGGATGGGAGTGGAGGCATTACATTCAGGAGAAAGGG
CAAGGGCCCCTGTGAGATCAGAGAGTGGGGGTGCAGGGCAGAGAGGAACTGAACAGCCTGGCAGGACATG
GAGGGAGGGGAAAGACCAGAGAGTCGGGGAGGACCCGGGAAGGAGCGGCGACCCGGCCATGGCGAGTCTC
ACTCAGCATCCTTCCATCCCCAGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGG
ACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCAGCTGCCCCAGCCAGGCCCTGCAGCTGGTGAGTGTC
AGGAAAGGATAAGGCTAATGAGGAGGGGGAAGGAGAGGAGGAACACCCATGGGCTCCCCCATGTCTCCAG
GTTCCAAGCTGGGGGCCTGACGTATCTCAGGCAGCACCCCCTAACTCTTCCGCTCTGTCTCACAGGCAGG
CTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATCTCC
CCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGC
AGGTGAGCCTTGTTGGGCAGGGTGGCCAAGGTCGTGCTGGCATTCTGGGCACCACAGCCAGGCCTGTGTA
TGGGCCCTGTCCATGCTGTCACCCCCAGCATTTCCTCATTTGTAATAACGCCCACTCAGAAGGGCCCAAC
CACTGATCACAGCTTTCCCCCACAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGT
GCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCCTCCCATCTGCAGA
GCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCCCAGCCCTGAGCCAAGCCCTCCCCATCCCA
TGTATTTATCTCTATTTAATATTTATGTCTATTTAAGCCTCATATTTAAAGACAGGGAAGAGCAGAACGG
AGCCCCAGGCCTCTGTGTCCTTCCCTGCATTTCTGAGTTTCATTCTCCTGCCTGTAGCAGTGAGAAAAAG
CTCCTGTCCTCCCATCCCCTGGACTGGGAGGTAGATAGGTAAATACCAAGTATTTATTACTATGACTGCT
CCCCAGCCCTGGCTCTGCAATGGGCACTGGGATGAGCCGCTGTGAGCCCCTGGTCCTGAGGGTCCCCACC
TGGGACCCTTGAGAGTATCAGGTCTCCCACGTGGGAGACAAGAAATCCCTGTTTAATATTTAAACAGCAG
TGTTCCCCATCTGGGTCCTTGCACCCCTCACTCTGGCCTCAGCCGACTGCACAGCGGCCCCTGCATCCCC
TTGGCTGTGAGGCCCCTGGACAAGCAGAGGTGGCCAGAGCTGGGAGGCATGGCCCTGGGGTCCCACGAAT
TTGCTGGGGAATCTCGTTTTTCTTCTTAAGACTTTTGGGACATGGTTTGACTCCCGAACATCACCGACGC
GTCTCCTGTTTTTCTGGGTGGCCTCGGGACACCTGCCCTGCCCCCACGAGGGTCAGGACTGTGACTCTTT
TTAGGGCCAGGCAGGTGCCTGGACATTTGCCTTGCTGGACGGGGACTGGGGATGTGGGAGGGAGCAGACA
GGAGGAATCATGTCAGGCCTGTGTGTGAAAGGAAGCTCCACTGTCACCCTCCACCTCTTCACCCCCCACT
CACCAGTGTCCCCTCCACTGTCACATTGTAACTGAACTTCAGGATAATAAAGTGTTTGCCTCCA
|
| Protein Name |
CSF3_HUMAN |
| Length |
207 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-JUL-1989 |
| Definition |
RecName: Full=Granulocyte colony-stimulating factor; Short=G-CSF; AltName: Full=Pluripoietin; AltName: INN=Filgrastim; AltName: INN=Lenograstim; Flags: Precursor |
| Primary Accession |
P09919 |
| Accession Version |
P09919.1 |
| Other SeqIDs |
sp|P09919.1|CSF3_HUMAN,gi|117564 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Mar 15, 2005 this sequence version replaced gi:87598, gi:1070573.; [FUNCTION] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.; [SUBUNIT] Monomer. {ECO:0000269|PubMed:10537111, ECO:0000269|PubMed:16492764}.; [SUBCELLULAR LOCATION] Secreted.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=3; Name=Long; IsoId=P09919-1; Sequence=Displayed; Name=Short; IsoId=P09919-2; Sequence=VSP_002673; Name=3; IsoId=P09919-3; Sequence=VSP_045246.; [PTM] O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).; [PHARMACEUTICAL] Available under the names Neupogen or Granulokine (Amgen/Roche) and Granocyte (Rhone-Poulenc). Used to treat neutropenia (a disorder characterized by an extremely low number of neutrophils in blood).; [SIMILARITY] Belongs to the IL-6 superfamily. {ECO:0000305}.; [CAUTION] PubMed:2420009 misquotes the gene name as 'CSF1'. {ECO:0000305}.; [WEB RESOURCE] Name=Neupogen/Granulokine; Note=Clinical information on Neupogen/Granulokine; URL='https://www.neupogen.com'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/csf3/'. |
| Source Db |
UniProtKB: locus CSF3_HUMAN, accession P09919;; class: standard.; extra accessions:A8MXR7; created: Jul 1, 1989.; sequence updated: Jul 1, 1989.; annotation updated: Oct 12, 2022.; xrefs: X03438.1, CAA27168.1, X03656.1, CAA27291.1, X03655.1, CAA27290.1, M17706.1, AAA35882.1, AF388025.1, AAK62469.1, CD013926.1, AC090844.7, M13008.1, AAA03056.1, A24573, FQHUGL, NP_000750.1, NP_001171618.1, NP_757373.1, NP_757374.2, 1CD9_A, 1CD9_C, 1GNC_A, 1PGR_A, 1PGR_C, 1PGR_E, 1PGR_G, 1RHG_A, 1RHG_B, 1RHG_C, 2D9Q_A, 5GW9_A, 5GW9_B, 5GW9_C, 5GW9_D, 5ZO6_X; xrefs (non-sequence databases): CCDS:CCDS11357.1, CCDS:CCDS11358.2, CCDS:CCDS42314.1, PDBsum:1CD9, PDBsum:1GNC, PDBsum:1PGR, PDBsum:1RHG, PDBsum:2D9Q, PDBsum:5GW9, PDBsum:5ZO6, AlphaFoldDB:P09919, BMRB:P09919, SMR:P09919, BioGRID:107827, DIP:DIP-61120N, IntAct:P09919, STRING:9606.ENSP00000225474, Allergome:8367, CarbonylDB:P09919, GlyGen:P09919, iPTMnet:P09919, MetOSite:P09919, PhosphoSitePlus:P09919, BioMuta:CSF3, DMDM:117564, MassIVE:P09919, PaxDb:P09919, PeptideAtlas:P09919, PRIDE:P09919, ProteomicsDB:2347, ProteomicsDB:52279, ProteomicsDB:52280, Antibodypedia:799, DNASU:1440, Ensembl:ENST00000225474.6, Ensembl:ENSP00000225474.2, Ensembl:ENSG00000108342.13, Ensembl:ENST00000394148.7, Ensembl:ENSP00000377704.3, Ensembl:ENST00000394149.8, Ensembl:ENSP00000377705.4, GeneID:1440, KEGG:hsa:1440, MANE-Select:ENST00000394149.8, UCSC:uc002htp.4, CTD:1440, DisGeNET:1440, GeneCards:CSF3, HGNC:2438, HPA:ENSG00000108342, MIM:138970, neXtProt:NX_P09919, OpenTargets:ENSG00000108342, PharmGKB:PA26941, VEuPathDB:HostDB:ENSG00000108342, eggNOG:ENOG502SCNA, GeneTree:ENSGT00390000017328, InParanoid:P09919, OMA:HHQVGGF, PhylomeDB:P09919, TreeFam:TF337698, PathwayCommons:P09919, Reactome:R-HSA-449836, Reactome:R-HSA-6783783, Reactome:R-HSA-9674555, Reactome:R-HSA-9705462, SignaLink:P09919, SIGNOR:P09919, BioGRID-ORCS:1440, ChiTaRS:CSF3, EvolutionaryTrace:P09919, GeneWiki:Granulocyte_colony-stimulating_factor, GenomeRNAi:1440, Pharos:P09919, PRO:PR:P09919, Proteomes:UP000005640, RNAct:P09919, Bgee:ENSG00000108342, ExpressionAtlas:P09919, Genevisible:P09919, GO:0071682, GO:0005576, GO:0005615, GO:0043202, GO:0005125, GO:0019899, GO:0005130, GO:0008083, GO:0071345, GO:0071222, GO:0019221, GO:0030851, GO:0006955, GO:1901215, GO:2000251, GO:0030838, GO:0008284, GO:0051091, GO:0045639, GO:0033138, GO:0050731, GO:0014068, GO:0032092, GO:0051897, GO:0045944, GO:0045471, Gene3D:1.20.1250.10, InterPro:IPR009079, InterPro:IPR040117, InterPro:IPR030474, InterPro:IPR030473, PANTHER:PTHR10511, Pfam:PF16647, PIRSF:PIRSF001935, PRINTS:PR00433, SMART:SM00126, SUPFAM:SSF47266, PROSITE:PS00254 |
| Sequence |
magpatqspmklmalqlllwhsalwtvqeatplgpasslpqsfllkcleqvrkiqgdgaalqeklvsecatyklchpeelvllghslgipwaplsscpsqalqlagclsqlhsglflyqgllqalegispelgptldtlqldvadfattiwqqmeelgmapalqptqgampafasafqrraggvlvashlqsflevsyrvlrhlaqp |
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