|
|
| Record Information |
| Record ID |
148 |
| Pubmed ID |
32186960 |
| SNP |
rs30936687 |
| Gene ID |
3553 |
| Protein ID |
P01584 |
| Vaccine Adverse Events |
|
| Vaccine |
inactivated Japanese encephalitis vaccine |
| Gene Name |
IL1B |
| Official Symbol |
interleukin 1 beta [Homo sapiens (human)] |
| Aliases |
IL-1, IL1-BETA, IL1F2, IL1beta |
| Other Designations |
interleukin-1 beta; IL-1 beta; catabolin; interleukin 1beta; preinterleukin 1 beta; pro-interleukin-1-beta |
| Chromosome |
2 |
| Location |
2q14.1 |
| Annotation |
Chromosome 2 NC_000002.12 (112829751..112836779, complement) |
| MIM |
147720 |
| DNA Sequence |
>NC_000002.12:112829751-112836779 Homo sapiens chromosome 2, GRCh38.p14 Primary Assembly
TTTTTTTTTCTTCAGTGAAGTTTATTTCAGAACCATTGAACAGTATGATATTTGCTCATTTATAAATATT
CCCATTTAAATAATCTGAGCTTATATATTTTCAGTCTTAATTAAAGGACTTGATTTAAAGAGAGCACACC
AGTCCAAATTGAATTGATTCCATAGCTATTAAAAACTAGGCTCTTTTACAGACACTGCTACTTCTTGCCC
CCTTTGAATAAATTAGACCAATGAATAAAACAAACAAACAAATAAATAAATAAATAGGGAAGCGGTTGCT
CATCAGAATGTGGGAGCGAATGACAGAGGGTTTCTTAGAACCAAATGTGGCCGTGGTTTCTGTCAGGCGG
GCTTTAAGTGAGTAGGAGAGGTGAGAGAGGCCTGGCTCAACAAAAGGGCTGGGGATTGGCCCTGAAAGGA
GAGAGCTGACTGTCCTGGCTGATGGACAGGAGATCCTCTTAGCACTACCCTAAGGCAGGCAGTTGGGCAT
TGGTGTAGACAACAGGAAAGTCCAGGCTATAGCCGTACTCAAAAACCTTTCTGTTCCCTTTCTGCCAGCC
CTAGGGATTGAGTCCACATTCAGCACAGGACTCTCTGGGTACAGCTCTCTTTAGGAAGACACAAATTGCA
TGGTGAAGTCAGTTATATCCTGGCCGCCTTTGGTCCCTCCCAGGAAGACGGGCATGTTTTCTGCTTGAGA
GGTGCTGATGTACCAGTTGGGGAACTGGGCAGACTCAAATTCCAGCTTGTTATTGATTTCTATCTTGTTG
AAGACAAATCGCTTTTCCATCTTCTTCTTTGGGTAATTTTTGGGATCTACACTCTGCAGCGAAAGAGAAA
GAAGAATTTTTGTGGGGCAAGGGACAAAGATGCTATGGGAAAGATGTTCTTTGGGTTGGCCAGAAAGGAA
ACTGACGAGCAGGTCACATGATCAGGAGCCAGACTCCTGAGTTGTAACTGGGCCCCCAACTTTCCGTGTG
ATTATTAAAAGAGCCCTTCTTCTTTTCTAAAACTTAGTGCCAAATGCTGAGGAGCATAATGTAGGTGAGA
ATTTTTTTTTTTTGGGGGGGTGAAAATTAAGCTAGAGCTTCTTGAAGTACCTAGTTTCCAGGGGCTTTTT
ATTGTATTTTTCCTTATGGTCCTAGAATGACATCAACTTGGAAATGAAGCTTTTGCTGAGAAAGCTGGAG
GTGATAGTGGTGGTAATTTTGGGAGTGGAGTGGACATGATAATGGGACCCTTTAAGTCATCTATTTCCCA
AGGTGTCTATCAAATGAGAGCAGCCCTAACAATATATAATCTGTTGGGGTTGTAACTATGGTAGGACATA
ATAACATCGGCAAAATGATTTAATTTTCTGCAGCAGGATTGAAGGTTGCACGCAGTTAAAAATTATGTTA
AATTTATTTACATTAATGCAAAATTGTCAAATAGACCTGTTCCCAGCTTTTCCTAGGGATGGGGGCGGGG
AGAAGGTGGTTGTCTGGGAATAAGTGGTAGCAGGAGGCTGAGAAGGGCTTCATTCCATAGCATTCACTTA
CCTCCAGCTGTAGAGTGGGCTTATCATCTTTCAACACGCAGGACAGGTACAGATTCTTTTCCTTGAGGCC
CAAGGCCACAGGTATTTTGTCATTACTTTCTTCTCCTTGTACAAAGGACATGGAGAACACCACTGAAGAA
AGAAGGGGGTCTTGTGGTTAGGGACACAGCAGTGCAGGGTCACCCCAACCCCTAGGCCCCATGAGTAGGA
TACATGTAATTTGGTAGCCTCTGTGGGAACCCACAGTGAGGTTCCTTGGCCTAAGACACAGGATAACTTG
ACTTCTCACAGACAATAGCAGGGTCATTTTGTTGATTTAGGGTTTCCCCTCAAAGGCCTGAGGGTTTCTC
AGAGCCTCATAGCAGTAGGAACGGAGAATGAAAGAGGGTCTACATTTTAAATGCTGAAGGAAGGAAGGAA
GGAAGCCATTGTGTCACTGGCTGGCAATGTGCCCATCCACAGGAGCGGAACAACTTGATCAATGTGGAAG
GAAAGGAAAGAGGTGAAGCTGTACTTCTGCCAGAAATCAGGCACCAGAACTGTTTCAGGAACAGAGAGTA
GCCCATGGGAAGAAACTGGGAGAGGAGAGGCTGAGCTGGGAAAGTGGCTCCAAAGAGAGACACTCATTTT
GATCTTCCTCAGTCACAGCAGTGTCAATTGGAGGCCCTGGGATCACTCTTACTACCCGATTCCAAAGAAA
CAGGATTTTCTTGGCCTGGCTGAGAGCAAATAGCTTCCCCCTGAGTGAGGCTGTCCTTCAAAGTCAGCAG
CCTTAGTTGCCCACACTCCTGTGCAGAGGCTTTGGCTACTGTGGCACGATGCCAGGCAGATCACCACAGC
TAATGATGGGTTCACCGCACTTGAAACTTTTGCCCGTTACAGCGGAGAGATATAAGTTCCTGCTGGGCGG
TAAAATTTCCCTACAAGGAACCACCTGGCATTGGGTGGGACGGATGTTGGGGCAAGGGGGGAAGACTGGG
GAGGGGGATGGACACATTATCGCTCCAGCACTCTTGTTTCAGCCTCAACAACAGGAAGAGAGAACCCACA
GGCAGTTAGGCCATGTCCATCAAATGACCCCATATTGTGGAAGAATTGACATTGCACTATGCCCAAGAGA
CTTGGGTGGACATGGTCCTGGGAGTGCTTGAGCCGTCTAATTTCTCAGGGTCACACTCCTGTTAACAAAT
GCACTGGCCAGTGCAATCAAATGTGCCATTTCTAGGACCAAAGTTTGTATATTCCTTTTTAATATTTTTT
TTCACTTGTGTTGATCATTTGCCTTAAATTAACTTTCTACTTTGTTTAAAACATGGAGAATTAGCAAGCT
GCCAGGAGGCCAGGCAGGGAAACCAGGATGTTTCCATTTACCTTGTTGCTCCATATCCTGTCCCTGGAGG
TGGAGAGCTTTCAGTTCATATGGACCAGACATCACCAAGCTTTTTTGCTGTGAGTCCCGGAGCGTGCAGT
TCAGTGATCGTACAGGTGCATCGTGCACATAAGCCTCGTTATCCCATGTGTCGAAGAAGATAGGTTCTGA
AATGTGGAGCACATGTTGTTTAGGTATAAAATCAGAAGGGCAGGCCTCGTGAGGCGAGGCGGCAAAATTT
GATTTCTTGGAGGACACCTGAGCATATACGGTCAAAGTCTGATGACAACACCAGTAGGGATGAAGCTGGG
AGTGGGGTGGCTAAGAACACTGGACCTGACACTATTAGACATGGGTTCCAGCTTCAGGTCTATTACTGCT
CACTGTGGCCGAGCAACAGAGCTACTTAGGTAAAATGGTGATGGTCATAACACTAGCCCACAGGGAGGTT
ACGAACCTCTGGTGACAATGTAAGTGAAAGGCCCCTGAGAAAGAGTGAGGGAGTTGCAAATGTCAGTAGC
CATCAAGATCTTCTTTAAGAATAGTTTCCACTAAAGAGATGATTGCTTTGGTTTCCAGCCTTCTTTGTTT
TGTCTCCCCGCTGGGCCTTCTACCTTTAAAGGGCTTTGGCTCTGGGGGAATTGAGTTGGCTGGGGCTTGA
TGACTTCCAAGAGGACACAAGTGGAGATCTACTGCCTGCTCTTGGCTAACTACCTTCTTCAAAGATGAAG
GGAAAGAAGGTGCTCAGGTCATTCTCCTGGAAGGTCTGTGGGCAGGGAACCAGCATCTTCCTCAGCTTGT
CCATGGCCACAACAACTGACGCGGCCTGCCTGAAGCCCTTGCTGTAGTGGTGGTCGGAGATTCGTAGCTG
GATGCCGCCATCCAGAGGGCAGAGGTCCAGGTCCTGGAAGGAGCACTGCGGAGAGAGCGAGGGAGGGAGC
CTGGTGAGGTGGTCCTGCCAGGAACCATGCTTTGACATCAGAGAGTAGAAAGCTCAGAGAGGAGGAAAGG
GCTTGAAAGAATCCCGAGCTTCTAAAGATCATCCCTCTCTGGGCCAGGCGTGGTGGCTCATGCCTGTAAT
CCCAGCACTTTGGGAAGCCGAGGTGGATGAATCATTTAGGTCAGGACTTCAAAACCAGCCTGGCCAACAT
GGCGAAACCCCTTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGGGTGCACCTGTAATCCTAGC
TATTCAGGAGACTGAGGAAGGAGAATCGCTTGAACTCAGGAGGTGGAGGATGCAGTAAGCCAAGATTGTA
CCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCTGTCTCATAAAACAAAACAAAACAAAACAAAACA
AAATAAAATAAAATAAAATAAAAAGATTATCCCTCTCTGAAGCTCAAGGAGGTTAAGTGTGTACTCAAGG
GCACACAGCAGGTTAGAGGCAGACTCAAGACTAGAATGTGGGCTTTCTGACACCTTACAGGCTATTCTTT
TAGAATAAATCCCATTTCTACTTTGTTCATCTTTTTTGTACATGCCCCACCTACACCATACATGTATACC
TTCTCTATATCTTTTTGTATCCCTAATGCTGTCACACTATGATTTGCTTTTTCATGCAGATGACCATAAC
ATTTTCCATTCACCTATGCTCACTCAGCAAGTATTCAATTTTTCTACACTGTTCTTTTTTTTCCTTTTTC
ATAACACTGTCTCATAGGCATTCTGCAAATCCTGTGAGAGTACTTTTTGTGAAATGTTACCACTTTCCTC
TTATTCAGAGAAGCTCCGTATTAAGGCTTCACTGAGGTTGCCTTAAGGCATGATAATGGTTCAAAGGCTT
GAAAGACAGTTAAAGAGACCTGTAAGTGCACAAAAGAAAGTTGAGCAGGAGAGAATTTCCTGCCTGGAGC
AGAGCCAAGCTGCTGGAAGAGGCAATGGGGGCAAAGGCCAGGCAGACAAGCCAATGGGCTCCTCCCACAG
CTGCAGCCAACAAGTTATGCCAGTCTTAAAACTTCTAAAGAAATATGTTTTTAACAAGATTGAGGACTGG
ATTATGAGGCTAGGGGAGGCTATCACAAACTGGAATAAAATAAAGCCAGAGAAAAGTGGCTGCCTCCCAA
CCTGCACAACTGACCTAGCTAGGCTGATGGCTGGGCCACCTAGGAAGGCTACTGAGCATCATATAAAACA
GAAGGGACAGCAGGAATATAACATGGCTCTTTGTAAGGATGAGTCTGAAAAATGACCATTTGCTGCCCAA
ATGCCCTTAGCTACAACTGAAAATATTTCAGAACTGGAGGTTGCAGGATGCTGGAATCTCAGAGATCATC
CAGCTCAGCCCTTTATTTTTCAGATGAGGTCCAAAGCGGGTAAAATGACTTGTCAAGGTCAAACAGCAAG
TGAATGGTTTTCTTTCAAGTCTCAATTCATCTTTTTGTTTATATCATCTATGTCTTGTTGTTATAAGCTT
CACCCCAGGTAGCAAAAAACTATTCTACTCAAAAGGGGTAGACATATGTTAGTTCTCAAGATCATCTCTT
GGTTTCAGAGTTTAACTCAAGTGATTGGCATAGGCTGAATCCATCTCTTAAAAGGATAATCAAATTTATG
TTGAAGACTTGGTTGTCTTCCTACTATGAAATGGGAAACATTATCACTACTCCTCCCCTGTCACCACCAA
GTGTGGCCACCACCACCAACGTTAGTGAGTGACTGTGGTGATATGATGACCAAGTGGCCAGGTCAGCAAG
TGGTGCAGCCTGTGTCTCACTGGAAGAGGTTAAAGTCTTTCTAAAACAAAATACCATGGCATCAAAGTGG
CCCAGAACTCCCTTCTTTGAGCTTTCCCTGTGTTAGAGCCCTTCCTTGGGTTGGGAGTTAAACCCATAGT
CTTACCTTCATCTGTTTAGGGCCATCAGCTTCAAAGAACAAGTCATCCTCATTGCCACTGTAATAAAAAC
AGGGACATGTCTCAATTATGTCTTCTAAACAGGTTTATTTTTCCTTCCCTGTGTACAAGACTTGACTGTT
CATAAGAAACTGCAAACAGCCTGCCTCTCAAAGCTGCCTGAAACACCTGGCAAGTTTCACAGTGATATGC
GCAGAACAGTCCAGAAGGCAGATTCTAGGCCTGGCAGGTGGGCACCCTGGGTGCTCCCTGTTGGATCTTG
AGGCCTAACCTCTAGCCCAGCAGAGTCAGCTAAAATCTGAGCTCTCCCTCTCCCTCCAAGCCACACTTTG
CAAAGGGATTCCTTGTATTGTGGGCTTGGAGTCTTTTCTCCCCATTTGCCTCTGCAGGAAGCCCTTGCAA
CAACACATCTGGATAGCCTCCAGGTCCCAAGGCTGGAGGGACTTGTAATGGGAAAGTAGTCTTTAAATCA
GATTTACTTGGCACCCTGTTTGCCACTGAAAGAGGCAATTTAGGGGAAAAATCTGGTCTCCAAGCACAGA
TAACACTCTACTCTTGAAAGAGGAGACCTGCTCATGTTACTGGTCTCAGCGTCTCCACTGACCTGTAATA
AGCCATCATTTCACTGGCGAGCTCAGGTACTTCTGCCATGGCTGCTTCAGACACCTGTGTAAAAAGGAGA
AAATGAGTGACTTCCCCATGACGGCTACGTTCATGTGTGATTTCTCTCAGCATCCAGTGCATGGCAGTCA
TGCAAAGAAATGATCTCTGAGTAAATGAATGAATGTGTGAAAGAGAAGTCCTTTGGGTCTAGAGAAAAGC
ATTTGCTAAACCAAACCCCAACTAGCAATGTATTGGCTAGGAGAGCTGGAGCAGAGGCTTTGACACTAAC
CTTTAGGGTGTCAGCTGTTAGATAAGCAGTATCCATTCCCAGAATATTTCCCGAGTCATAAGCATTATAT
TACACCTGGCATTTTTGCAAAAAGCTGAGAGAGGGAGGCAGAGAGGGAAGGAGAGGGAGAGACAGAGAAA
GAAAGAGAGAGAGAGAGAGAATATGCATACACACAAAGAGGCAGAGAGACAGAGAGACTCCCTTAGCACC
TAGTTGTAAGGAAGATTAAAGTCATACTTGAGCAATGAAGATTGGCTGAAGAGAATCCCAGAGCAGCCTG
TTGTGCCTTGTGCCTCGAAGAGGTTTGGT
|
| Protein Name |
IL1B_HUMAN |
| Length |
269 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
21-JUL-1986 |
| Definition |
RecName: Full=Interleukin-1 beta; Short=IL-1 beta; AltName: Full=Catabolin; Flags: Precursor |
| Primary Accession |
P01584 |
| Accession Version |
P01584.2 |
| Other SeqIDs |
sp|P01584.2|IL1B_HUMAN,gi|62906858 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Apr 3, 2008 this sequence version replaced gi:74740790, gi:74740829, gi:74713130, gi:124303.; [FUNCTION] Potent pro-inflammatory cytokine (PubMed:3920526, PubMed:10653850, PubMed:12794819). Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed:3920526). Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33377178, PubMed:33883744). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:3920526}.; [SUBUNIT] Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all (PubMed:17431422). Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling (PubMed:29030430). Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form (PubMed:32272059). Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC (PubMed:32272059). Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC (PubMed:32272059). {ECO:0000269|PubMed:17431422, ECO:0000269|PubMed:20802483, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:32272059}.; [SUBCELLULAR LOCATION] Cytoplasm, cytosol {ECO:0000269|PubMed:15192144}. Secreted {ECO:0000269|PubMed:11728343, ECO:0000269|PubMed:15192144, ECO:0000269|PubMed:33883744}. Lysosome {ECO:0000269|PubMed:15192144}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P10749}. Note=The precursor is cytosolic (PubMed:15192144). In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted (PubMed:24201029, PubMed:33377178, PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:15192144, ECO:0000269|PubMed:24201029, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:33883744}.; [TISSUE SPECIFICITY] Expressed in activated monocytes/macrophages (at protein level). {ECO:0000269|PubMed:15192144}.; [INDUCTION] By LPS (PubMed:15192144). Transcription and translation induced by M.tuberculosis and a number of different M.tuberculosis components in macrophages; EsxA is the most potent activator tested (at protein level) (PubMed:20148899). In pancreatic islets, release is increased by high glucose treatment. In pancreatic islets and macrophages, release is also increased by endocannabinoid anandamide/AEA (PubMed:23955712). {ECO:0000269|PubMed:15192144, ECO:0000269|PubMed:20148899, ECO:0000269|PubMed:23955712}.; [PTM] Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated. {ECO:0000269|PubMed:15192144}.; [MISCELLANEOUS] The IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated. {ECO:0000269|PubMed:15192144}.; [SIMILARITY] Belongs to the IL-1 family. {ECO:0000305}.; [WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL='http://atlasgeneticsoncology.org/Genes/IL1BID40950ch2q13.html'.; [WEB RESOURCE] Name=Wikipedia; Note=Interleukin-1 entry; URL='https://en.wikipedia.org/wiki/Interleukin_1'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/il1b/'. |
| Source Db |
UniProtKB: locus IL1B_HUMAN, accession P01584;; class: standard.; extra accessions:Q53X59,Q53XX2,Q7M4S7,Q7RU01,Q96HE5,Q9UCT6; created: Jul 21, 1986.; sequence updated: Apr 26, 2005.; annotation updated: Oct 12, 2022.; xrefs: K02770.1, AAA36106.1, M54933.1, AAA59136.1, X02532.1, CAA26372.1, X04500.1, CAA28185.1, M15330.1, AAA59135.1, M15840.1, AAA74137.1, X56087.1, CAA39567.1, BN000002.1, CAD29872.1, BT007213.1, AAP35877.1, CR407679.1, CAG28607.1, AY137079.1, AAM88883.1, AC079753.7, AAX88888.1, CH471217.1, EAW73605.1, BC008678.1, AAH08678.1, A21851, ICHU1B, NP_000567.1, 1HIB_A, 1I1B_A, 1IOB_A, 1ITB_A, 1L2H_A, 1S0L_A, 1T4Q_A, 1TOO_A, 1TP0_A, 1TWE_A, 1TWM_A, 21BI_A, 2I1B_A, 2KH2_A, 2NVH_A, 31BI_A, 3LTQ_A, 3O4O_A, 3POK_A, 41BI_A, 4DEP_A, 4DEP_D, 4G6J_A, 4G6M_A, 4GAF_A, 4GAI_A, 4GAI_B, 4I1B_A, 5BVP_I, 5I1B_A, 5MVZ_U, 5MVZ_V, 5R7W_A, 5R85_A, 5R86_A, 5R87_A, 5R88_A, 5R89_A, 5R8A_A, 5R8B_A, 5R8C_A, 5R8D_A, 5R8E_A, 5R8F_A, 5R8G_A, 5R8H_A, 5R8I_A, 5R8J_A, 5R8K_A, 5R8L_A, 5R8M_A, 5R8N_A, 5R8O_A, 5R8P_A, 5R8Q_A, 6I1B_A, 6Y8I_A, 6Y8M_A, 7CHY_I, 7CHZ_I, 7I1B_A, 9ILB_A; xrefs (non-sequence databases): CCDS:CCDS2102.1, PDBsum:1HIB, PDBsum:1I1B, PDBsum:1IOB, PDBsum:1ITB, PDBsum:1L2H, PDBsum:1S0L, PDBsum:1T4Q, PDBsum:1TOO, PDBsum:1TP0, PDBsum:1TWE, PDBsum:1TWM, PDBsum:21BI, PDBsum:2I1B, PDBsum:2KH2, PDBsum:2NVH, PDBsum:31BI, PDBsum:3LTQ, PDBsum:3O4O, PDBsum:3POK, PDBsum:41BI, PDBsum:4DEP, PDBsum:4G6J, PDBsum:4G6M, PDBsum:4GAF, PDBsum:4GAI, PDBsum:4I1B, PDBsum:5BVP, PDBsum:5I1B, PDBsum:5MVZ, PDBsum:5R7W, PDBsum:5R85, PDBsum:5R86, PDBsum:5R87, PDBsum:5R88, PDBsum:5R89, PDBsum:5R8A, PDBsum:5R8B, PDBsum:5R8C, PDBsum:5R8D, PDBsum:5R8E, PDBsum:5R8F, PDBsum:5R8G, PDBsum:5R8H, PDBsum:5R8I, PDBsum:5R8J, PDBsum:5R8K, PDBsum:5R8L, PDBsum:5R8M, PDBsum:5R8N, PDBsum:5R8O, PDBsum:5R8P, PDBsum:5R8Q, PDBsum:6I1B, PDBsum:6Y8I, PDBsum:6Y8M, PDBsum:7CHY, PDBsum:7CHZ, PDBsum:7I1B, PDBsum:9ILB, AlphaFoldDB:P01584, BMRB:P01584, SMR:P01584, BioGRID:109769, DIP:DIP-474N, IntAct:P01584, STRING:9606.ENSP00000263341, BindingDB:P01584, ChEMBL:CHEMBL1909490, DrugBank:DB05767, DrugBank:DB11967, DrugBank:DB06168, DrugBank:DB12140, DrugBank:DB00843, DrugBank:DB05442, DrugBank:DB10772, DrugBank:DB05260, DrugBank:DB12119, DrugBank:DB01017, DrugBank:DB06372, DrugBank:DB05412, DrugBank:DB05133, DrugBank:DB05470, DrugBank:DB05507, DrugCentral:P01584, TCDB:1.A.109.1.2, iPTMnet:P01584, PhosphoSitePlus:P01584, SwissPalm:P01584, BioMuta:IL1B, DMDM:62906858, EPD:P01584, MassIVE:P01584, MaxQB:P01584, PaxDb:P01584, PeptideAtlas:P01584, PRIDE:P01584, ProteomicsDB:51391, ABCD:P01584, Antibodypedia:771, DNASU:3553, Ensembl:ENST00000263341.7, Ensembl:ENSP00000263341.2, Ensembl:ENSG00000125538.12, GeneID:3553, KEGG:hsa:3553, MANE-Select:ENST00000263341.7, UCSC:uc002tii.2, CTD:3553, DisGeNET:3553, GeneCards:IL1B, HGNC:5992, HPA:ENSG00000125538, MalaCards:IL1B, MIM:147720, neXtProt:NX_P01584, OpenTargets:ENSG00000125538, PharmGKB:PA29808, VEuPathDB:HostDB:ENSG00000125538, eggNOG:ENOG502S3E9, GeneTree:ENSGT00950000182943, HOGENOM:CLU_083639_0_0_1, InParanoid:P01584, OMA:QHYSKGF, OrthoDB:1243742at2759, PhylomeDB:P01584, TreeFam:TF300203, PathwayCommons:P01584, Reactome:R-HSA-448706, Reactome:R-HSA-5620971, Reactome:R-HSA-5660668, Reactome:R-HSA-6783783, Reactome:R-HSA-6785807, Reactome:R-HSA-9020702, Reactome:R-HSA-9660826, SignaLink:P01584, SIGNOR:P01584, BioGRID-ORCS:3553, ChiTaRS:IL1B, EvolutionaryTrace:P01584, GeneWiki:IL1B, GenomeRNAi:3553, Pharos:P01584, PRO:PR:P01584, Proteomes:UP000005640, RNAct:P01584, Bgee:ENSG00000125538, ExpressionAtlas:P01584, Genevisible:P01584, GO:0005829, GO:0005576, GO:0005615, GO:0005764, GO:0030141, GO:0005125, GO:0005178, GO:0005149, GO:0019904, GO:0006915, GO:0048143, GO:0007267, GO:0097398, GO:0071222, GO:0071260, GO:0071407, GO:0071310, GO:0071466, GO:0019221, GO:0050830, GO:0035234, GO:0007566, GO:0097192, GO:0001660, GO:0030213, GO:0007249, GO:0006955, GO:0006954, GO:0070498, GO:0007254, GO:0031663, GO:0000165, GO:0070487, GO:0070164, GO:0008285, GO:2001240, GO:1903597, GO:0010829, GO:0046627, GO:0050995, GO:0045833, GO:0043407, GO:0050768, GO:0050805, GO:0030593, GO:0045766, GO:0060559, GO:0060355, GO:0051781, GO:0030335, GO:0008284, GO:0045917, GO:0051091, GO:0045893, GO:0010718, GO:0031622, GO:0010628, GO:0060252, GO:0032725, GO:0034116, GO:0043123, GO:0033092, GO:0050729, GO:0032729, GO:0032743, GO:0032755, GO:0032757, GO:0046330, GO:0050996, GO:0043406, GO:0051044, GO:0045840, GO:0071639, GO:0035505, GO:0150078, GO:0051092, GO:1901224, GO:0045429, GO:1900745, GO:0050766, GO:0031394, GO:0032308, GO:0046827, GO:0001934, GO:1902680, GO:0002711, GO:0042102, GO:2000556, GO:0045944, GO:0010575, GO:0030949, GO:0043491, GO:0050691, GO:0070372, GO:1903140, GO:0043122, GO:0050796, GO:0050767, GO:0050999, GO:0033198, GO:0009743, GO:0070555, GO:0032496, GO:0030730, GO:0007165, GO:0014805, GO:0010573, InterPro:IPR003296, InterPro:IPR020877, InterPro:IPR000975, InterPro:IPR003502, InterPro:IPR008996, PANTHER:PTHR10078, PANTHER:PTHR10078:SF30, Pfam:PF00340, Pfam:PF02394, PRINTS:PR00264, SUPFAM:SSF50353, PROSITE:PS00253 |
| Sequence |
maevpelasemmayysgneddlffeadgpkqmkcsfqdldlcpldggiqlrisdhhyskgfrqaasvvvamdklrkmlvpcpqtfqendlstffpfifeeepiffdtwdneayvhdapvrslnctlrdsqqkslvmsgpyelkalhlqgqdmeqqvvfsmsfvqgeesndkipvalglkeknlylscvlkddkptlqlesvdpknypkkkmekrfvfnkieinnklefesaqfpnwyistsqaenmpvflggtkggqditdftmqfvss |
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