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| Record Information |
| Record ID |
143 |
| Pubmed ID |
34526360 |
| SNP |
|
| Gene ID |
3430 |
| Protein ID |
P80217 |
| Vaccine Adverse Events |
transient lymphopenia, injection site reaction, fatigue, flu-like symptoms temporally related to vaccination, and arthralgia and decreased lymphocyte count, asymptomatic transient elevations in autoimmune serologies |
| Vaccine |
IGFBP-8 N-terminus plasmid-based vaccine |
| Gene Name |
IFI35 |
| Official Symbol |
interferon induced protein 35 [Homo sapiens (human)] |
| Aliases |
IFP35 |
| Other Designations |
interferon-induced 35 kDa protein; IFP 35; ifi-35 |
| Chromosome |
17 |
| Location |
17q21.31 |
| Annotation |
Chromosome 17 NC_000017.11 (43006784..43014456) |
| MIM |
600735 |
| DNA Sequence |
>NC_000017.11:43006784-43014456 Homo sapiens chromosome 17, GRCh38.p14 Primary Assembly
CAAACAGCCTGCGAGCAGAGCCTCCTGAGGTGTATTTCGGGTCTTGCTGGGGCTGAGAGAGACCACAGCC
CTTTGGGGGGTACAAACAAGAGTTCAGTTGCTGTGAATTCTGCCACTGTGCCCAGCTCTGAAGCCTCAGC
TCTTGCCAAACAGACCCGAGACCCATGTCAGCCCCACTGGATGCCGTAAGTGAGGAGGAGGGAGTTGGGA
AGTGGGGAAACAGGAGTAATCCTCTTGGCTAGGAACCTGCAGATATCTCAGGGCCTGGCAGCCAAGCCTC
ACCCTGCCCATCTCAGACCTGCTGAAGGGCTGGGGAGAAACACAGGGCTGGGGTTGCCTCTGCAAGAGTT
GGTTCCCTAACCTATTGCCTCAGACAGGAGGAGCTCATTAAATCCTGTGTGTGTACACTTCTCTGGAGAG
AGAATCTGTAGTTTCCATCAGATACTCAGCGGGTTCTGTGACCCAAATAACAATTGTTCTAGGCCGGGCG
TGGTGTCTCACGCCTGTCATCCTAGCACTTTGGGAGGCCTTGGCAATACAGTGAAAATCCGTCTCTACTA
AAATACAAAAAATTAGCTGTGTGTGGTGGTGTGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGG
AGAATCACTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCATCACTGCACTCCAGCCTGGGT
GACACAGCGAGACTCTGTCTAAAAAAAAAAAAAAAAAAATTAAACTAAAGGAATTAGGCTGGGTGTGTTG
GCTCACACCTGTAATCCCAGCCAGCACTTTGGGAGGCTGAGGCGTGTGGATCACTTGAGGTTAGGAGTTC
GAGACCAGCCTGGCCAACATAGCAAAACCCCATCTCTACTAAAAACACAAAAATTAGCCAGGCATGGTGG
CACACACCTGTAATCCCAGCTACTAGGGAGACTGAGGCGGGAGAATTGCTTGAACCTGGGAGGCAGAGGT
TGCAGTGAGCCGAGATTGTACCACTATGCTCCACTCTGGGCAACAGAGGGAGACTGTCTCTCACACACAC
ACACACACAAAATTTATATATATATATATATATATATATACTATAAGAATTATACTTTAAGAATCACACT
AGGTAATCCATAGATTAACACGGTAAAAACTTATCCCACTGCTTAGCACCTACAGAGCATTCAATATGTG
TTTCTTCTTAATATTATTATTGCCAACCTTTTCAGAACCCCAGTTCCCCAAGGACAATCCCTTTTTTTTT
TTTTTTTTTGAGACGGAGTCTCACTCTGTCTCCTAGGCTGGAGTACAGTGGCATGATCTCGGCTCACTGC
AACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAACTGGGAGTACAGGCACGT
TCCACCATGCCTGGCTAATTTTTTGTATTTTTAGTAGAAATGGAGTTTCACCGTGTTAGCCGGGATGGTC
TTGATCTTCTGACCTCGTGATCTGCCCCCCTCAAGCTCCCAAAGTGCTGGGATTACAGGTGTAAGCCACC
ATGCCCGGACTTTTCTTTCCTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCACTCTTGTTGCCCAG
GCTGAAGTGCAATAGCATGATCTTGGCTCACTGCAACCTCTGCCTTCCAGATTCAAGTGATTCTCTTGCC
TCAGCATCCCAAGTAGCTGGGATTATAGGCACACATGCCACCACGCCTGGCTCATTTTTTTTTTTTTTTT
TTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCAGGATCTCGGCTCACAGCA
AGCTCCGCCCCATGGGTTCATGCCATTCTCTTGCTTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCG
CCACCACGCCCAGCTAGTTTTTTGTATTTTTGGTAGAGATGGGGTTGCACTGTGTTAGGCAGGATGGTCT
CGAACTCCTGACCTCGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCG
TGCCCAGCATGGCTAATTTTTTGTAGAGACAGGGTTTCAGCATGTTGGCCAGGCTGGTCTCGAACTCCTG
ACCTCACATGATCTGCCTCCCTTAGCCTCCCAAAATGCTGAGATTACAGGCTTGAGCCACAGCACCCGGC
TTTATATACGTTAAATTGGGCCATCTTTTTCAAATAAAAATCCAGATTTTTTGTTTTTTGGAGACAAGAT
CTCACTGTTTTTTCCAGGCTGCAGTGCAGTGGCTGGATCATGGCTCACTGCAGCCACCTCCACCTCTAGG
GATCAATAGATCCTTCCATCTCAGCCTCCCGAGTAGCTGGGACTACAGGCATGTGCCACCATGCCTGGCT
AATTTTTAAATATTTTGTAGAGGTAGAGTTTTGTCCTGTTGCCCAGGCTGGTCTCAGACTCCTGGGCTCA
AGCGATCTGCCTCCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGTGCCACAACAACCTGCCCAGAT
TTTTTATTTCTATTAAAAATGGGAAGATTAGGGGGCCTGGGTCCGTGGCTCCTGCCTGTAATCCCAGCAC
TTTGTGAGGCTGAGTTGGGCAGATCACTTCAGGTGGGAAGTTTGAGACCAGCCTGGCCAACATGGTGAAA
CCCCATCTCTACTAAAAATAAAAAATTAGAGCCGGGCACGGTGGCTCACTCCTGTAATCCCAGCACTTTG
GGAGGCCGAGGTGGGTGGATCACGAGGTCAAGAGATTGAGACCATCCTGGCCAACATGGTGAAACCCCAT
CTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGTGCGTGCCTGTAGTCCCAGCTACTCGGGAGGCT
GAGGCAGGAGAATCGCTTGAACCCGGGAGTCAGAGGTCGCAGTGAGCCGAGATCCTGCCACTGCATTCCA
GCCTGGCGACAGAGCGAGACTCTGTCTCAAAATAAATAAATAAATAAAAAATAAAAAAAATTAGCCAGGA
GTGGTGGCAGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCTGTTGAATCCGGGAGG
TGGAGTTTGCAGCGAGCCGATATTGCGCCACTGCACTCCAGCCTAGGCAACAGAGGGAGACTCCGTCTCA
GAAAAGAAAAAAAAATAGAGGGCTGGGCGCGGTGTCTCACACCTGTAATCCCAGCACTTTGGGAGGCTAA
GACGGGCAGATCATGAAGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAA
AAATACAAAAAAATTAGCCAGGCGTGGTGGCGGGCACCTGTAGTCCCAGCTAATCGGGAGGCTGAGGCAG
GAGAATGAAGTGAACTGGGAGGCGAAGCTTGCAGTGAGCAGAGATCGCGCCACTGCACTCCAGCCTGGGC
GACAGGGTGAGACTCCGTCCCAAAAAGAAGAAAAAAAAAAAATAGCTGGCATGATGGCACACGCCTGTAC
TCAGGAGGCTGAGATGAGAGGATTGATTGATTCCAGGAGGTCGAGGCTGCAGTGAGCCATAATGGAGCAA
TTGCACTCCAGCCTGGGTGGCATTGAGACTTTGTCTCAAAAAACAAAACAAAACAAAAACATGGGTAGAT
TTGCTGTGGGGGGAAACTTTGTTATGGCTAGAAGCAGTTTACTTTAGAAAGGACATGCTCTTCCCAGTGC
GTCAGAGTCCCCACCACTCTCTGTTATCCTACATGGCTCTATTAACTCATTAATGTCATCCAACTGGCCC
TTAAAGGCACTGTGTTAGCACTCTCTGAGTTACAGAAATATGAATAACTAATGATCTTTTTCACTATTCA
TAAACCAGCATAATTTGGTCAAGCTCTAGTATTCTTCTGCTAAAAATAGAACAAACTCACACTGAATTTC
TTTGGTGTCCTCTGTAATGTGCTCCTTTACCGTCATTCATTCACTTCATTTCTTCATTCAACACAGTTTT
ACCGGACACATATTTTGTGCCGGAGATCTTGCTGGACACAAGGAATACAGAGATGGTCAGAACAGAGTCC
TATCTTTCCAAGAGATCTCATGCTTCTCTGAGCTGAACTTCTTTATCAGGATTCCTAACCACAGGGTGAA
CTCTGCTCTATTCCACAAACAAAGGTGCATTTATTGGTATCCCTGGTGTCACTTCCCTGCCTGTGATGTC
AGTTCTCTCTCTGGACCCATTCCAGATCACACCCAGCCTAAAAGGTTACTTGGTGTACAGTGGAAAGTGT
GACAGTCCAGGGACAAGCTAGAATTGATGGGTAAACTACCTCCCCACTCTGGGCTTCATTTCTTCACTGT
AAAGCACAGGTTAGTGGGTGGGCTCTGGAGTCAGACAGCCTAGGGCCAAATGACTTTGGGCAAGTCATTT
AACCTCTCTGAGCTTTAATTTCCTCATCTATAAAATAAGGATTGGCCAGGCATTGTGGCTTACACCTGTA
ATCCTAGCACTTTAGGAGGCCGAGGCGGGCAGATCATCTGAGGTCAGGAGTTTGAGACCAACCTGGCCAA
CATGGTGAAAACCTGTTTCTACTAAAAATACAAAAATGAGCCAGGTGTGGTGGTGGGTGCCTGTAATCCC
AGCTACTTGGGAGGCTGAGGCAGGAGAATTACTTGATCCTGGGAGGTGGAGGCTGCAGTGAGCCAAGATC
GCGCCACTGCACCCCAGCCTGGGAGACAGAGCAAGACTCTGTCTCAAAAATAAATAAATAAATAAAAATT
AAAAAAATAAATCAATAAAATAAGGATCACAGGATATCTATCTTAGATACCCTGTTGTTCTAAGAATTGA
ATGAAATAATTCATCAGACGGGCTTAGCACAGTGCCTGGCATATAGTAAGTACTTAGTAAACGTTAGTTA
AGAATATGACTGTATGACATTTTGCAACTAGTCTCCCCTCCTCTTGGAGGTGTCCCTAATTGGGTTAACC
CCTTTGGGATTGTCCCTCTTCCAAATTCCGGCTGCCCTTCACAGTCAGTCATGTGATCATGTACTCTTGA
GCACTGTTTGGCAGGCCTGAGGGTCGTACCCTTATCTTCCACTGCCTGTGTCAGTGCCGAGCACTTTCTA
GCAGGAGCTTAATCAGTGTTTGTTGAACTCTAGATCTGTGGTCACGAACAAGTCATGGACGCTGCAAAGG
CTCCTGCCCTTTCAAGAGCAGCTGAGATGAGGCCAGCCAAGCCCTGGGTGGAGGGGGCCAAGACCAGCCC
AGGGCAGCACAAAGGGGTTGGGTTGTTCTTGAGCTTAGCATCAACTCTGCTTTTGGAGCGTCCAGAATAG
GCCCCACTTCCCCTGGGCTTGTTGATTCTCTGGAAGGGCGGGTAGAAGTCTTGTTGTTTCCTTCTGCCCC
AACAGGCCCTCCACGCCCTTCAGGAGGAGCAGGCCAGACTCAAGATGAGGCTGTGGGACCTGCAGCAGCT
GAGAAAGGAGCTCGGGGACTCCCCCAAAGACAAGGTAAGGTGGGAGATCTGGTGTTGTTTGGTAAAAACG
AGCTGGCGAGGCCGGGTGCGGTGGCTCACACCTGTAAACCCAGCACTTTGGTAGGCCAAGGGGGCCTGAT
CACCTCAGGTCAGGAGTTTGAGACCAGCCTGGCCAACACAGTGAAATCCCATCTCTACTAAAAATACAAA
AATTAGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCTGGTGGATCACC
TGAGGTCAGTTTGAGACCAGCCTGGCCAACAGGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGC
TGGGTTTGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGTCCGAATTGCTTGAACCTGGGA
AGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTACACTCCAGCTGGGTGACAGAGCAAGACTCCCTTTA
AAACAAAGAAACACAAAAAAGAGCTGGGGAGTTCTCGGTTTTATTCCTGGCTCTGCTACTTCCTTGCTGT
GTGACCTCCATTATGTTACTTGAACATCTGTAAAGTAGAGCTACCCACCTCCCAGGACAAATTAAGATGT
TGTATGTAAATTGCCCTGTATGGACCAGACCTGCATTCATCCACTCATTTATCCAGCTTTTCTTTCAGTA
AATGTATTTATCTCCGGCACTCAGCATCAATGGAATGGAATCGGAGATGCCTTCCTCCTAGGTGGGAGTG
AGGAACACTCCTACTCCCCTCCCCTACTTCCAGGTCCCATTTTCAGTGCCCAAGATCCCCCTGGTATTCC
GAGGACACACCCAGCAGGACCCGGAAGTGCCTAAGTCTTTAGTTTCCAATTTGCGGATCCACTGCCCTCT
GCTTGCGGGCTCTGCTCTGATCACCTTTGATGACCCCAAAGGTAAGCTCATGGGGAGCCTCAGGAGGGAG
GTGGGGAGGGTTCCCAGTACTGACCCTGTTTCCCACCACCCAGTGGCTGAGCAGGTGCTGCAACAAAAGG
AGCACACGATCAACATGGAGGAGTGCCGGCTGCGGGTGCAGGTCCAGCCCTTGGAGCTGCCCATGGTCAC
CACCATCCAGGTGATGGTATGACAGAATCCTGGGGCATGCAAAGCATGCCATGCACCTGGGCATGGGGAA
GTGGAGCTGTGTCTGGGACCACCCCTTGCTGTCTCCCCCTAGATGTCCAGCCAGTTGAGTGGCCGGAGGG
TGTTGGTCACTGGATTTCCTGCCAGCCTCAGGCTGAGTGAGGAGGAGCTGCTGGACAAGCTAGAGATCTT
CTTTGGCAAGACTAGGAACGGAGGTGGCGATGTGGACGTTCGGGAGCTACTGCCAGGGAGTGTCATGCTG
GGGTTTGCTAGGGATGGAGGTGAGGGCTATGCAGGCCTCCTGCAGGGGAGAGGGTATAGGGTGTGCAAGA
TTACGGTGCAGGGAGAGGAGAGGGCTTGATGCTAAAGGCCCACCCCTCCTTGCTCCCCACAGTGGCTCAG
CGTCTGTGCCAAATCGGCCAGTTCACAGTGCCACTGGGTGGGCAGCAAGTCCCTCTGAGAGTCTCTCCGT
ATGTGAACGGGGAGATCCAGAAGGCTGAGGTAAGCAGGAGGGGTGAAGAACAGGGGCTGGGCTGGGTAAC
CTGTCTGCCTGCCAGGAACTTGCCCAATGAAGGATCAGAGGCCCCAAACCCCACTGACCTACCTACCCAC
CATCAGCCTCTCCAGGCCTCCCGACCTCATACCCCCATGGGGCACTGCCTGCCCTACCCCCAGCCCCCAG
CCCTTCTCCCATGAGCCTTTGCCATCTCCTGGCTCCTTTTCCAGATCAGGTCGCAGCCAGTTCCCCGCTC
GGTACTGGTGCTCAACATTCCTGATATCTTGGATGGCCCGGAGCTGCATGACGTCCTGGAGATCCACTTC
CAGAAGCCCACCCGCGGGGGCGGGGAGGTAGAGGCCCTGACAGTCGTACCCCAAGGACAGCAGGGCCTAG
CAGTCTTCACCTCTGAGTCAGGCTAGGGGCCTCCCCTTCTCATCCTCCCCACCCCCCCGCCAAGGTTCTC
ACACTGGCCTGGGCTTGGGTGCCCATATAGGAGGTCTGTATGTTCACCAACAGTGCGGAGGGGTCACACA
TTGCAAAACACTGCCCAGAACAGTAAAAAGAGCCTGCATGCCA
|
| Protein Name |
IN35_HUMAN |
| Length |
286 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-FEB-1994 |
| Definition |
RecName: Full=Interferon-induced 35 kDa protein; Short=IFP 35; Short=Ifi-35 |
| Primary Accession |
P80217 |
| Accession Version |
P80217.5 |
| Other SeqIDs |
sp|P80217.5|IN35_HUMAN,gi|311033494 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Nov 3, 2010 this sequence version replaced P80217.4.; [FUNCTION] Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465). {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:29350881}.; [SUBUNIT] Homodimer (PubMed:8288566, PubMed:10950963). Also interacts with BATF (PubMed:8954125). Interacts with TRIM21 (PubMed:26342464). Interacts with NMI; the interaction is direct and is facilitated by TRIM21 (PubMed:10779520, PubMed:10950963, PubMed:26342464). {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:8288566, ECO:0000269|PubMed:8954125}.; [INTERACTION] P80217; Q6UXB4: CLEC4G; NbExp=4; IntAct=EBI-2115067, EBI-2114729; P80217-2; P54253: ATXN1; NbExp=3; IntAct=EBI-12823003, EBI-930964; P80217-2; P46379-2: BAG6; NbExp=3; IntAct=EBI-12823003, EBI-10988864; P80217-2; O75934: BCAS2; NbExp=3; IntAct=EBI-12823003, EBI-1050106; P80217-2; O43739-2: CYTH3; NbExp=3; IntAct=EBI-12823003, EBI-11974015; P80217-2; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-12823003, EBI-12593112; P80217-2; O14645: DNALI1; NbExp=3; IntAct=EBI-12823003, EBI-395638; P80217-2; A0A0C4DGQ7: EML2; NbExp=3; IntAct=EBI-12823003, EBI-12112376; P80217-2; Q14192: FHL2; NbExp=5; IntAct=EBI-12823003, EBI-701903; P80217-2; P21333-2: FLNA; NbExp=3; IntAct=EBI-12823003, EBI-9641086; P80217-2; O14901: KLF11; NbExp=3; IntAct=EBI-12823003, EBI-948266; P80217-2; P31153: MAT2A; NbExp=3; IntAct=EBI-12823003, EBI-1050743; P80217-2; Q13287: NMI; NbExp=4; IntAct=EBI-12823003, EBI-372942; P80217-2; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-12823003, EBI-2811583; P80217-2; Q8N2W9: PIAS4; NbExp=3; IntAct=EBI-12823003, EBI-473160; P80217-2; P37840: SNCA; NbExp=3; IntAct=EBI-12823003, EBI-985879; P80217-2; P00441: SOD1; NbExp=3; IntAct=EBI-12823003, EBI-990792; P80217-2; Q13148: TARDBP; NbExp=6; IntAct=EBI-12823003, EBI-372899.; [SUBCELLULAR LOCATION] Cytoplasm {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:8288566}. Nucleus {ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:8288566}. Secreted {ECO:0000269|PubMed:29038465}. Note=Cytoplasmic IFI35 localizes in punctate granular structures (PubMed:10950963). Nuclear localization increased is stimulated by IFN-alpha (PubMed:8288566, PubMed:10950963). Extracelullar following secretion by macrophage (PubMed:29038465). {ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:8288566}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P80217-1; Sequence=Displayed; Name=2; IsoId=P80217-2; Sequence=VSP_003569.; [TISSUE SPECIFICITY] Expressed in a wide range of cell types, including fibroblasts, macrophages, and epithelial cells. {ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:8288566}.; [INDUCTION] Up-regulated by interferons IFN-alpha and IFN-gamma. {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:8288566}.; [DOMAIN] The NID domain 1 is involved in the negative regulation of p65/RELA transcription and the negative regulation of NF-kappa-B pathway activation. {ECO:0000269|PubMed:29350881}.; [PTM] Phosphorylated. Dephosphorylation correlates with the formation of a complex with NMI. {ECO:0000269|PubMed:10779520}.; [MISCELLANEOUS] [Isoform 2]: Due to a polymorphism at the 3'-splice acceptor site of intron 4. {ECO:0000305}.; [SIMILARITY] Belongs to the NMI family. {ECO:0000305}.; [SEQUENCE CAUTION] Sequence=AAB61703.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}. |
| Source Db |
UniProtKB: locus IN35_HUMAN, accession P80217;; class: standard.; extra accessions:C9JGX1,Q92984,Q99537,Q9BV98; created: Feb 1, 1994.; sequence updated: Nov 2, 2010.; annotation updated: Oct 12, 2022.; xrefs: U72882.1, AAB61703.1, AC055866.19, BC001356.2, AAH01356.1, L78833.1, AAC37597.1, JC5262, NP_001317159.1, NP_005524.2; xrefs (non-sequence databases): CCDS:CCDS11450.1, CCDS:CCDS82134.1, AlphaFoldDB:P80217, BioGRID:109656, CORUM:P80217, IntAct:P80217, MINT:P80217, STRING:9606.ENSP00000395590, GlyGen:P80217, iPTMnet:P80217, PhosphoSitePlus:P80217, BioMuta:IFI35, DMDM:311033494, EPD:P80217, jPOST:P80217, MassIVE:P80217, MaxQB:P80217, PaxDb:P80217, PeptideAtlas:P80217, PRIDE:P80217, ProteomicsDB:57673, ProteomicsDB:57674, Antibodypedia:29492, DNASU:3430, Ensembl:ENST00000415816.7, Ensembl:ENSP00000394579.3, Ensembl:ENSG00000068079.8, Ensembl:ENST00000438323.2, Ensembl:ENSP00000395590.2, GeneID:3430, KEGG:hsa:3430, MANE-Select:ENST00000415816.7, UCSC:uc021txx.2, CTD:3430, DisGeNET:3430, GeneCards:IFI35, HGNC:5399, HPA:ENSG00000068079, MIM:600735, neXtProt:NX_P80217, OpenTargets:ENSG00000068079, PharmGKB:PA29645, VEuPathDB:HostDB:ENSG00000068079, eggNOG:ENOG502QUNN, GeneTree:ENSGT00530000063686, HOGENOM:CLU_047262_1_1_1, InParanoid:P80217, OMA:YMSGKIQ, OrthoDB:1133123at2759, PhylomeDB:P80217, TreeFam:TF332752, PathwayCommons:P80217, Reactome:R-HSA-909733, SignaLink:P80217, BioGRID-ORCS:3430, ChiTaRS:IFI35, GeneWiki:IFI35, GenomeRNAi:3430, Pharos:P80217, PRO:PR:P80217, Proteomes:UP000005640, RNAct:P80217, Bgee:ENSG00000068079, Genevisible:P80217, GO:0005737, GO:0005829, GO:0005615, GO:0016020, GO:0005634, GO:0042802, GO:0045087, GO:0002281, GO:0008285, GO:1901223, GO:0050729, GO:0045089, GO:1901224, GO:0034145, Gene3D:3.30.70.330, InterPro:IPR034460, InterPro:IPR009909, InterPro:IPR009938, InterPro:IPR012677, PANTHER:PTHR15225:SF1, Pfam:PF07334, Pfam:PF07292 |
| Sequence |
msapldaalhalqeeqarlkmrlwdlqqlrkelgdspkdkvpfsvpkiplvfrghtqqdpevpkslvsnlrihcpllagsalitfddpkvaeqvlqqkehtinmeecrlrvqvqplelpmvttiqmssqlsgrrvlvtgfpaslrlseeelldkleiffgktrngggdvdvrellpgsvmlgfardgvaqrlcqigqftvplggqqvplrvspyvngeiqkaeirsqpvprsvlvlnipdildgpelhdvleihfqkptrgggevealtvvpqgqqglavftsesg |
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