|
|
| Record Information |
| Record ID |
142 |
| Pubmed ID |
34526360 |
| SNP |
|
| Gene ID |
3560 |
| Protein ID |
P14784 |
| Vaccine Adverse Events |
transient lymphopenia, injection site reaction, fatigue, flu-like symptoms temporally related to vaccination, and arthralgia and decreased lymphocyte count, asymptomatic transient elevations in autoimmune serologies |
| Vaccine |
IGFBP-7 N-terminus plasmid-based vaccine |
| Gene Name |
IL2RB |
| Official Symbol |
interleukin 2 receptor subunit beta [Homo sapiens (human)] |
| Aliases |
CD122, IL15RB, IMD63, P70-75 |
| Other Designations |
interleukin-2 receptor subunit beta; CD122 antigen; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; interleukin 15 receptor, beta; interleukin 2 receptor, beta; interleukin-15 receptor subunit beta; p75 |
| Chromosome |
22 |
| Location |
22q12.3 |
| Annotation |
Chromosome 22 NC_000022.11 (37125838..37175118, complement) |
| MIM |
146710 |
| DNA Sequence |
>NC_000022.11:37125838-37175118 Homo sapiens chromosome 22, GRCh38.p14 Primary Assembly
TTTTGTTGCATTGTACTTATTTTGTACAGTTACCTTTTATTTATAGCGAAAATGGGTTTTTTCATTTACA
GAGTAACAAAGATTTTTCTTTAAATAAATGTATTTCAACGAAAATGAACTGACTTAAAGAAAAAATATTA
AGGAAATAATCACAAAGATGGTACACACGGATCATTAAAAGATACGGATGTATAGATACATATGTCACAA
ATGATTAAGACTTAAAAAATGTAACCCTCCCAAGAAGTGGGAGCCTCCCAAAGTGGAGAAGGCAAATACA
ATTTCCATTTGGGGGGATAAGGAGACCGACTTGCAGAGAGGATTAGTAGGTTGCCCCAGAACACACAGCA
AAGGTGTGGAGCCCCTTGTGGTCTGAAACATTCAGGACCCTATGGCAGGAGGTGAGACTGTCCAATAATT
CAGCTTTTTTCAAGGCATAGACCCAAGACTCAGACAACCTCAAGAAAGGGGAGTTTATTTTGGATATAAA
GGCAACAGGAATCCTGACCAAATGGTCAGCAGCCCTCTCAGCAGTAGGTATTTTTGTATTGGGAACCCAA
GGTCCTCTGCTTAGTGGCTCAACGCTTGTCTACCTTTCCAAGGCTCAACGCTTGTGGAGCCTTGTCCACA
AGCACCTGCTCCCAAGGGCCTCCCTCCCTGAGTTCAAACGCCCAAGACAGAGTTGATCTGATTGGCTAGT
TCAGGCCCAGCCTACCTGATTGGACAGAGCTTGGTGCCAAACCCCCTCATAGGCTGCTGGTCAGAGCCTG
TGGGGGCGTGTGGTCAGGTGCCCAATCAGCTGTGAGCAAGGCCTGTAAGTGCAGGTGCCTGAGGGCTCCC
AGGTCAGAGTTAGCTGGGACTGGGGTCACTGTCCTGCTGGGGTGGAATGTTGTTTGAGCCATTGCAACGT
GATCTGCCTAGGAAAGATACGTGGAGGGGTCGGGGTAGGGGGTTGAGCCCCTTGCAGGAGGGGGCATGCC
AGACCTAATGGGCACGGGACTCTGCCTCTCTGTGTGAATGTCAGGCGCAGGGAGCCCAGACGAGGTGGTG
CCAGGTAATTAATTCGTTCATCCAGGGTATACGACGGGGTGTTGGGCACTGTGTCTGGGGCAGTGAAAAA
TAATGAGGCCCTGCCCTGTGGAGCTGCCCTTCTGGAGGCCAGTGTGCCAGTCCCTGAGCTGCAGAGGAGA
CCCCTCCAGTGGAGGGGGCAGTGGGAGGTCCCAGGCCTGGCAGCATCAGGGCCCACCACTAGGCGGGGCT
GCTGCCTGGGCCTCGGACTCCAGGGTTTACTCCCCATCAGCTTCTCTTGTGGGTCTGTGAAGCCACTGTG
GGAAGATGCAGCAGGCATCCACTTTGTGGGGGGATCTGTGCCCTTACTTGGGCCCCAGCATTAAAGATAC
AGCAGCCAAGCACTCTGAGGCCTCAGAGATCCCAAAGGAATAGTAACAGGGCCTCTTTCTCCAGGCGCCC
TGGGTCCCTGACAGCTTCTCCCTCCAGCACTGACGCTAGAAGTTTCTGGCAGATTAAGGGAGGCAGTGCT
TCCCTCCAGGAGAAGCAAAACCGGCACTTGAAGAGTCAGGGAAGTTTGTCACCTAGATGAGGGGGAGCGC
ACAGCAGCCCCAGGGAATAGCATGTGCAACAGAGGGGGTGTGAGGGAGCTCTGAGTGGCTCAGGAGGACG
GTAGGGAGGATTGCAGAAGGGGATGTCCCCACACGACACCGGAGGTACAAGTACCAGGCTGAGAAGTGGG
GCTGAGGGCAGTGGGACCTGTGCAAGGTTTTGAACCGAGGGGGAGCGTGGCCATATTTGGGTTTTGGAAA
GCACGCTCAGGCTGCCCTGTGGACGGGGAGGGGAGGGAAGGAGGAGGCTGGGGCAGAAAACCCAGGGAAG
AGGTCAGGGCAGGGAGCCCTGGAGAGCCGCGAGGACTGATATTGGTGAATAGCTGCAGGGCTGGAGAGGA
GCGATGCTTCTGAGCCTAAATTCGTGGGATCCTGTGATTAACGAGGGAGTTGGGGAGTTACTGCCCCCCT
GCAACACACACAGTTCCTGGCTCGGGCAGCAGGACCCGGGAGCAGCAGTGGAGGTTTGGAAATGGATGGA
CCAAGTGTGCAGGACTGGGTGGGGGCCATCCGGGTGGAGAAGTCCAGCTGCAACTGGACACTGAGTGTCC
TCAGCAGTGGACTGAGGACCCTCAACAGGGTCCTTCTGAGGCTCGGCGCAGAGCAGGCAGCTGCCTGCCT
CCCACCCTGGCCATCTGTCTACACCAAGTGAGTTGGGTCCTGACCCTGGAGTTCTTGGAGGGACAAGTAG
GCATCAGTGTTCAGGGGCAGGCGAGCATTAAGGGCCCTGAACTCCCCCTGCCCAGGAGGCCTGGACCAGG
GGAAACTGACTCCCTCCCTGGGGCCAGCGTCAGGGACCTCCTCCCCAGCCTCTCGCAGCACCAGCTCAGG
GGGTGGCTGAAAATCCACCAGGTCTGGGACTCCTGGGGTGGGAGGCCCCAGGGGCTGGGGGTCCCAGTCT
CTGGGGACTCTTTCTTGCAAAGAAGGGGGCATCCTCTCTTCACCGGCCCCACTGCCCCCAGGGGCAGTGC
TTGGGGGGCTGGGGCCACCGAGGAGACTGGGGGAGAAGAGCAGCAGGTCATCCCTGGAGGGGAAGGTGCA
GTAGGCGTCGTCCTCCCCTGACAGAGGCTGCAGGGGTTGGGGGGAAGACCCTGTGGGTGCCCCGGCCACA
CCCTCATCAGGGTCTTCCTCTGAGTAGGGGTCGTAAGTAAAGTACACCTGGCAGGCCTCTATCTCCAAGG
CATCCGGGAGGTGGAAGAAGAAGTAACCCTGGTTGGTGAAGCAGCTGGTCAGCGAGTGGTTGCTGCTTAA
GGATGCGGGCTCAGGCACCTTGTCCTGCTGCAGGAGCAGCTGCGTCACCTTGTCCCTCTCCAGCACTTCT
AGTGGCGAGATCTCAGGTGCCAGGCCGCCAGGGCTGAAGGACGATGAGGGGAAGGGCGAAGAGAGCCACT
TCTGGTGGGAGAAAGGCCAGGGGTGGGTGAGTGGGGGCTTCCTTCACCCTCCACCCCTTCCTCTGGACTC
TCAACAGCTCCTAACTCCTCCTCCTCCTGAAGCAGTTGGCCCAGGGCTGCCCCATCCAGGAAGCTCTCCC
TGATTATAGCCCCGCACTCCCCCAACCCACCCACTGGCTTGGGGGCCCTCTGGGCCACCAGCCCAGGGAC
ACTGCCTGACCCACAGCCCAGCACAGGCCTGCCTGGCTGCCAGTAGTGCCCAGGAATGTCTGATTGCTCA
AGAGTGACTGTTTATTGGACACCTGCTATGAGCCTGGCACTGTTCTAGATGCTGGGGACCCAGGAAAGGA
GAGAATCCTCAGACTGTCTAGTGGGCACTAGCACAAGTGTGGGAATCGATCCACCCATGCCAAAGCAGAA
GGGCACTGAGAGTACAGCCTGTTCACCCTACAGATGCCCAGAGACGGGACATGCCCTGGCCCTGATCACA
GACCAGCAGGCGGCAGAGCTGGGACCCAGGGTCTCCGCTTACACTGTGGTGGGAACGTCTCTTGGGGGAG
CTGATGGTTTCCTGATTCACCTTTCCCCCAGTTCCCTGCAGTCCCCACCCCCACCCCCTCCGCCTCCCAT
CCCCAGAGAGAGGAAAGTGCCCATCAGAGCACTTCTCAGTTGCTCGGGATTCCAGAGAGCCCTGGCAAGG
AGTGGGAAGACCCGGGTTCTAGCCCTGGCCCTGGCACTCACTAACTGTGTGACCCTGGGAGGGCCCCTGC
ACCTCTCTGGGCCTCAGTTTCCACAACAGCCACGTCTCTCCTGACTTCCTTGCTGTCACCCATCAGGTCA
CCAAGGAGACATCAGGTAAGCAAATGGAGATGTAAACACCCAAAACGGGTAAGACACAGACTGCACAGCA
GAGTGGGGGACAGCAGGCCCTCCTGGTGGTGTGGCAGGGGCCTCGGGTGGGTGAGTTTGGGAGCCCTGAC
AACCCTCTGTCCTGGGAACCCTCAGCAGCTGGACTATGGCCCCCTAAGCACAGGGGCCAGGCCCAATGGG
CTCCCCAGGCCTCTGTGCCCAGCATGGCGGGTCTCATGGATCTATTTCAGATGAATTAATGAACCAGCAA
CAAATGCCCAGTTCTCCTCTCCAGGGAGAGTCCCTGAGGCTGAGCCAGCTGCTCCGCAGACACACACACA
CACGCTTACATGCATGCACACATGCACACACGTGCACACACCACTCAATTAAATCCGCCCCCTTTCTGCA
ACCAGGAGTTATGTCACAAAAGAAAAGGCTGAGAGAGGCAGAAAGGATAAACTGAGGATGGCAAAGAGGG
TCGCTGGCTGGGCAGAGAGGAAGAAGCACTGGTCGGGTGAGATTCATGATACCCAGGGCAAGGGCGGGGC
CAGACAGCAGCCCTGTGTGTGCAGCCAGAGAGGGAGCGGCCAGGCCTGTGGCCAGTGCCGGTGAGCCAGG
GACCCACTGCCTGTGGCCAGCTACTTCCTGGGCCTGAGCCTCTGCCCACAATGCCCTGAAAGGGGCTTCA
GGAGACACTCACGCCCCTCACACATACTCCCACACTCGCACACACGTTCCACGATCCCCTGGGAAGTGGG
GGTGGGCCTTGTGGCCCCTGTGGGTCCTAGGGTGGAGGGGTAGGTCTCTCACCCAGATGCAGAAAAGGTG
GGGCCTGCTTTGCCATCCCCAACCCCCAGCCACATCATGCCTTCTTCCTCAGGACCCCGCTCCACACACT
AGACCCAAGGATACCATACCCTCATGGGAAGCTGGAATGGTTTGCAGCTCCCACCTCACGATGTTGTAGG
TTCATAGAATCAGGACTTGAAGCTGGAAGGTATCTGAGCATGCAGCTAATCTACCGCAGCCTCCAACCAG
TTCAATGGGAGAATCTCTATGCTTCTGACACATAGGCAACCATGGCTTGCTTGAATACCTTTATAGATGG
GAATCTTGCTACCCTCAAGGCTGAGGGAAGAATTTTAAGGAAATACATTCCCGCACATTAAGAGTACTGC
AACTAATGGCCAGGCACGGTGGCGCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCA
CCTGAGATCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCGTCTCTATTAAAAGTACAAGAA
TTAGCCAAGTGTGGTGGTGTGTGCTTGTAGTCCCAGCTACTCGGGAGACTGAGGCAGGAGCATCGGTTGA
ACCCAGGAGGCAGAGTTTGCAGTGAGCTGAGGTCGTGCCATTGCACTCTAGCCTGGACGACAGAGCAAGA
CTCCATCTCAAAAAATAAATAAATAAATAAATAAATAAAAGCACTGCAACTAAGATATTCTCATCTTGGG
AGTTTTCCAAGGAGTTCCAGAAGGGGCCCTTGATCAGCCCTGATAGAGAACTCCAAAGCCAGGTCATGAC
AGCTCTGGTCCGGCATGGCTTTCCTCCTCCGCCACTCTTCTTGACCTCCCTCTGCCCCTACCTCATCCCC
ACCCCCCAATCTTGGGAGCCTAGAGTGGGGCTAGGGTGGTAAAAAGTACCCCCCATGTCCCCCCTTCATT
CTTGAAGCTTCCTGCCTGAAGGGGGCATGGGCTGGGGAAGAGGAGACGACGGAATCTGAGATGGAGTTTA
GAGCGTTACTGATCTGCGGGCCGGCACTTTAAAAATGAATCGGTGTTTTGTGACTCAAAGTGACGGGAAG
ACTTGTTAGTATCCACGCTAAGTTATGGAGCCTGCTCAGGAATTTTGAGCAGGGACAGGAGAAGCACAGA
GCATGTCTGCACAGACAGTGGGGTGGAGAGAGCTTGTGCTGGCAGGTCCTGTTCGTTCAGCACACCGGCA
ACGGTAATACCAGATAGGGTACTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGA
GTGCAGTGGTGCCATCTCAGCTCACTGTAACCTCCGCCTCCTGGGTTCAAGCGATTCCCCTGTCTCAGCC
TCCTGAGTAGCTGGGATTACAGGCATGCACCACCAGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGG
GCTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCGTGATCTACCTGCCACAGCCTCCCAAAG
TGCTGGGATTACAGGCATGAACCACTGCACCCAGCCTGATAGGGTTCTTTTGAACACTAACTGCGTGCCA
GGCAATGTACTCAGGGCAGGACACATAGTAACACTGTTTTTCTCCTCATCTAACAGGTGGGGAAACTGAG
GCCCAGGGAGGCTCTATAGGCCCAAGGTCACACAGCCAGAATGTGGTGGAGCTGGGATTAGAACCCAGGC
AGTCTGGCTCAGATGGAAAGTGCCAGAGCTGGAGAAGAGACCCATGCACACCCCGGAGGCTGCTCACTTC
GGCGTTTTGTCTCCTCTCACAAAACACAAAATTAGCTACTAACCTGCCACCCCCTCATCCCACTCACACC
CCTGCCCACCTCTGTCTCCCCGCCCCGGCCTCCTACCTGGACGTCTCCTCCATGCTCTGAGCTCAGCTGG
GAAAAGAACTTCGAGGGGTCTGGGGTGTTACACTTCAGGACCTTCTTCAGCCTGGACAGAGGAGAGGAGG
GAAGGAGGAGGGTGAGAAAGGGAAGGACCGCGGTGTTATGCCATCGGCACCACAGCTCTGGATGCCAGGC
ACGGAGCCGCACCACATTTACTTATGTATTTCTTCCGCCGATACTAAGTGTTCACTGTGGGAGGACGCTG
TGTTGGGCACTGGGGAGACAAGAATGGCCAACAAAGGAGGTCCCTGCTCTCAAGGAGCTGACATTCTCAT
GGGGAGATGGACACAAAGCATGTTGCAACATCACCATTCATTCTGTGGAGACAGAGAGCACAGTGCTACA
CAAGACGGGGAGGTGGGGGTCGATGGGGGTGAACACACAAGCCAGAGTGGTCAGGGACGGAGATGGCTAG
AAGAAGTGGAATGAACCAGGAGGCGGGAGAGAGGAGATGGGCTTTCTTGTCAGGGCTGCCATGGATGGTG
GTTCAGGTTGTACACTGCCCAAGGGCATTAGGCTTGGGCAGGGAGTGGGAAAGGTGGTGGTGAGTGAGGC
TGAATTCCAGCCCATGTTCTGCTTGCTAAGCTGAGTGCCTGGAAGCTGTGTACATCACCGTGAAGAAAGA
GGCACCATTTTTGATTTGCCCAAAGGTTCCACACAGCTGGTGGAGGCCCTCAAGGGCCAGGGTGTACTGC
AGCGCAGTGAGCGGCCTCTGAAGAGTGTTAAACAGGAGAATGACATGGTGGAGAAAGCACTGAAGGGGCG
CAAGAACGACAAGGAGGAGGGCAGTCTGGAGGCCACTGAACCCATGCCTGGGAGAGGACCTCTCCCTCTA
CAGGGACATGGTTTCCCTGAAGGCCTGCAGGGAGCTGTGGGCGGAGGGGACGGGTGGGTGGAGGAATGCT
TGTCTTCTTGGGAGGAAAGAGGAAACGGGGCTCCGAACACTGCCGAGAACCACTGCTCCAGGACGAGGGT
CAGGAGAGCGGCAGTCACTCCTAACTGGCTATGTGACCTTGGGCAAGTCAGCTGACTTCTCTGGCCAGTC
CTGGCATCAGTTAAAAGGCAATGGTAGCCCCTGACTCACTGCCTTCCCAGTGCTGGGGAAAGTCGAGTGA
GGTGACACAGCTAGGCACGCTTTGCAAACCTCTTGGGAGAAGCAGGGCTCTCATCAGGGGGCCACAACCC
CCGGTCAGAAGTGTCACCTCCTCACCGCTTTGCCCTCCACCAGGCCACGCTCCACACAGCAGCCAGGGCT
ACAGAGGGCGAAGTGGATCCTGTCCCACTTCTGGGGAAACCCTCCATGACTGCTCGGCACACGGCCCAGG
TCCTCACCACAGCCTGAGGCCCCAGGAAGCATCACTGCCGCCACAGGCCCAGGCTCAAGTTCAGCCTCCT
GCCCCACCCACTTCTGTCTCCAGCCACACCAGCGCCCCTGCACTCTGTTCCTGGAAGTTTCTTCCCTCCT
GCCTGCCCAGGGCCTTTGCACATGCTGTTTCCTCTGCCTGGGACACTCTCCCCATCCCCTCCACACCCCC
CATGGGCTCCCACTACAGATTTCAACAGAATCATCCCTTCCTCAGGGAAACCAGCCCTGGCCACGCCCCA
GCCAAGTTTCCCCTCCCTGTTTTCTGCTCCTGATACAGTCAGCACTCAGGATCCGTGGGTTCTGCACTCA
CGGATTCAGCCAATCTCTGATCAAAAATATTCAGGAAAAAAAAACCCTCATAGCAATACAATAATAAAAA
ATAATACAAATTTTTAAAATACAGCATAACAACTATTTACATAGCATTTACATGGTATTAGGTATTATAA
GTAATCTAGGAGATGACCTAAAGTCTCTGGGAGGGTGTGTGTAGGTTACACGCAAATATTCTGCTGTGTT
AAATCAGGGACTTGAGGCCGGGCGTGGGGGCTCACACCTGTAATCTTAGCATTTTGGGAGGCCAAGGCGA
GTGGATCACCTGAGGTCAGGAGTTTGAAACCAGCTTGGCCAACATGGTGAAACCCCGTCTGTACTAAAAA
TACAAAAACTTAGCAGAGCACGGTGGCGTGTGCCTGTAGTCCCAGCTACTCGGGAGGATGACGCAGGAGA
ATCGCTTGAACCCTGGAGGTGGAGGTTGCAGTGAGTCGAGATTGCGCCACTGTACTCCAGCCTAGGTGAC
AGAGTGAGACTCTATCTCACAAAAAATAAATAAATAAAATAAAACAAAAATCAGAGACTTGAGTATCCAC
CAGCTTTGGTATCTGTAGGGGGTAGGGAGGGTCCTGGAACTGGTTTCCATGGATCCTAAGGAATGGCAAT
ACGTCGACATCCTCCTCTGCCATCCTGATCCCGGTGTGTCATTACACACCTGCATGATTGTCTGCCTTCC
CCCACTGGGCCGTGAGCTGCCTGGAGCTGGGGCGCATGCATGCGGCCTGCCACTGTGTTCCCAGCTCTTT
GAGCTGTACCTGGCATGCAGCTCGTACTCAGTGAATATGGGAATAAGCGAATGACAGACCTAGATGGACC
GGCGGGGACCCAGACACAGAGACAGCTGACATGTGCACACGGGCATCCCCAGTCCTGAGAGCAGTGTTCT
GGACAGGGCCCCGGGGCTCTCCCTGGAGGGCTGCACCTCCCACCTTCCCCTCGGGTTGGTTCCACAGGGC
CCCCCTGTGGGGATGCGACACAGGGAAAGGCCAGGTTTTGGACAGGGAGGACTCTTTGGAGGGTAGACGA
AGCACGGGTGTATCAGAGCAGGGGGTTCGGTCCAGAATCTGACCTGGCAAGGTGGCATGTGTTCATGTAA
GTGTGTGTGTGTGTGTATGTGTGCTTGTGTGCGTGTGTGTGCATGTGTGTGCATGTGTGTGCACGTTGGA
GGGGTGGGAGCATGAAGGAAGGGGAGGAGAACCTTCTTACCATGGCCCGGTGTTCCTGCAGTTGATCAGC
AAGTACACTAAGATGATGAAGCCAAAAGCCCCGCTGAGGCCCACGAGGAGGTGGCCGAGCCACGGAATGG
TGTCCTTCCCAAGGGCTGCCCAGGGGTGGGAGAAACAGCAAGGAGAGGGGTTAGAGAAGTGCCCTCACTC
ACCCTGGGTCGGTCACCCCAACACCCCCATCCAGGGCCCTGCCACGCAGGCCTGCGTCTGGGGGGCTGGG
GACAGGGTTCTGCTAAGCCCATCCTCTGGGAAGCCAGATTTCATGCTAAAAAGAAATGACACGGTGGCAT
TCTAAGAGCTCCTCCAGCTCCAGACAGATCCCATGGGCCCCCCTGGTGAGCCTACAGCCCCCCACCACCC
CCACAGCAGCCTGGGCTCCAGCTGGCTGCACCCCTCTCTCCACCTCCCTCCAAGCACCACTTAGAGGACC
CCAGGTCTTGCTTGGGCTTGAACTCGAAATGTGGTGCGATGAGGGACAGGCGCCCAGCAGACCTGCTGAG
GGCCAGGCTGCCGGGACATCACACGCCTTCCTCACAGCAGCTCTGCCTCACGGTCACTGTACCCATTTCA
CAGATCAGGCCGAGAGGTGAAAGCAGCCACCCCCAGCCCCAGAAGAAACCAGGAGTTGGAGATTTCAGGG
TGGAGAAGAGTGAAAACAGCCTTTCGACCCCTCCCCAACTCACAAGGCCCATGGCAAGCCCCGTCCCCTC
ACTGAACCCCTGTTCCTGTCTGAAAAGCGAGCCCCCTGCAGGGTTACAGCAAGTGAGGGATGGAGCTGAC
TGCTATACCCTCACCCCAGGCAGGGAGAGAATGGAGCAGCTCCTCCTCCAGCCGCCCCCTCCTGCCTGAG
CCCCCTCTCACCCTTGCCGCCCACCAGTACCTGCAGGCTTTGTCCTGAAGGCCAGGGGCTGGCTCCAGGG
GCTCCAGGTCGTGAACTCGCCTTGCAGAGGCTTGACCCGCACCTGAAACTCATACTGGGTGTCTGGGGTG
AGCGTCTCCAGGCAGATCCATTCCTGCTTCTGCTTGAGAGTCAGCAGGGGGGCCTCCTGGGTCGGAGACA
GGACTGTCAGCGCCCACCTCACCTCCCATGGCAGGGCCAGGAGGCTGAGCATCACAGAACCCCCCCCCAA
CCCCTGCCAGCTGCACCCCCACTTCCTTGCCACCCAAAGCTCCCTCACTACCCAGTTGCTGGGGCCTCAA
ACCCCAGGGTCATCCCCTAAAGCCCAAGTCATCAGCTAATCAGCTGGTTCCACCTCCAGAACCTGGTTCC
ACCTCCATAGCCATTCCAGAACCATCCCCCTCTCTCCCCGCCGCACTCACCCCAGGCCTGAGCTGCCGCC
CTCTCCCAAGCCTGCAGCTGGTCTCTGGTTCCCACCCGTGCCCCGCTGCAGTCTAGTCTCCACAGGACCA
GAAAGTGGGACGTCTCCGCACACCTCTCCCACCCTGGGTCACTCTTTTTGCCTCCTCCTGCTCCCCAGAC
ACATAGCAGCATCCTGCCTTTGCCGTGGCAGGTCTTTCTAATTTTGCAAAACTTCTCCCCAGATCTTTGC
AGGTCAGCTCCTTCTGGACACCCAGGTGTCCAAGGGGCCTTCCCTGGTCACCTGAGTCTGAAGTAGCCTG
TGCCAGTCACTGTCAAATTCCTTGCCCCGTTGGGTTTTCTTGATGGAACTTATCACTATCCGGGTGCCTC
ACTATCCCAGACCCTGTCGCTACATCTGCTGACTGACTGCCTGCCTGCCCTGCCCCAGTCTGAGATTCCT
GAGAGTGGAAGTTTGCTGAGCTCACCCTCCGCTCTCTCCCCATCATTCAGCGCATAGTAGGTGCTCAGCA
AATATTTATTGAGTGAGCAGTTGAGTGAATGAAGAAATGAGTGTAAGTGAATGAATAAGCAACAGGCCCG
CACGGATGTGGAGCAGATGGGCTTTGACACGTGGAGGGTTGGCTTCCCTGGCCTCTGAAAGCCCATGGGG
CTGGGCAGCTGCCTATCTCCTGGCTTTCTGAATCTTTCCCTGGTGTCAGCCTGGAACCTGCTGCCAGCTG
GATCCCCAGGATTAAGGGGGCTAGATAAGGACGTGGAAGTCGGGGAGGCAGCCCCAGGCAGTGCAGAAAG
AGCACTGGACTCAGCCACCCACCATCCACCTGGGGCTGAGGGGACCTCGACACAATGAAAAAGGGACAGG
ACATGGACCAGGACAGGAAGGAGGAACCAAGGCAGGTACGGACTGGGCCACATTCTCACCTCCCAGGTGT
GGCCTGGGGACAGCGTCCGGGCCTCGAACTCCAGGTGTCTTTCAAAGTAGTGGGAGGCTTGGGAGATTTC
CCAGCTTATGTTGCATCTGTGGGTCTCCACGTGGACAACTTGGAGGGAGATGGGGGCCATCAGGCGAACT
GGAGACAACAGGGGGTAGGGGAGAGCAGTCAGCCATGACCTCCACCTCCCACTTTGTACCTGCCACTCCT
CCCTCCTGGCACATGCTACCACCTCCCCTACCCCCCGACCCAAAGCCCCAGGACCCGCTCCCTCACTGCC
TCCAGGCCTCTCTCAATGATCACCTCTTGAGAGAAGCCTTCCCTGACCACTCACCACTCTGCATCCCCCT
TGCCTGTTTCACTTTTATTCCCAGTGCTTATCATCACCTGACCTACGAAATATATGGTTTGGTTTCTTTA
CTCATTTTCTGTCTCCCCCAGCAGACTGTGAGCTCCTTGAGGGCAGGGACTTGGTTGTCTGCTGTGTCCT
TGGCACCTGGAAGATTACCTGGCACTTGATTCAGTAGCTGCTGGATGAATGACTCACGGCAGCTTTTCTC
TGCACTTACAATTGACCTGAGAGCTTTCCATGGATCATCTCATTTATTTTAAGTGTGATGATTATAACAC
TGTGATTCTGAAGTTAAATGAATCTCAGTTTCTATACTTCTAAGACTCTATAGAACCACATAAGTGATAA
GCAGATGCTGAGTGCTGACTACATGGTAAGCAGTTTCTATGTCTCAGTTCAAAGATGCCTTACAAGCCTG
GTAGGTAGGTGACTCCGATTCTCCCCAAAACTCAGGCTCAGAAAGTTTCGATGGTCTGCCAGTCAGATCA
CATCCAGTTCAGGCCTGACTCTCACTTTCCACCCCACTGCTTCCCTGGAGATGGCCCCCAAGGTCAGCAG
GCAGTCGCTCAGGCATTCAACAAACCTTCCCAGACCACTGTCCTGATGAGACCTAGTGCTGGGTGCGTGG
CAAGGAGACACAGGGGTGGCAGAGACTCTGCCTTCAGGGTGCTCACAGCCCAGTGAAAGAGACAGACCTA
CAATCAGGCAGTAACAACCCAGGACATACATTCCCAGAAAGAGGAGGTACAAAGGGCTAGGGGAGTCTAG
GAAGGCCTCCTGGAGGAAGTGACTTTCAACTAAGCCTCGAAACGTGAGTGGGAATTTTCCAGGTGTAAAG
GGCCTTCCAGGCAGTGGGATCGGCATGTGCAAGGGCTCAGAGGCAGGGATAGGCAAGGTGGGTTTGGAGA
GTTGGCCTTTGGCTGTAGCAGAAATATAGGCCTCAAGAGGAGGAGTGCCGGGGAGGAGGCCCAGGGCTGG
ATCCTGAGCGGCCTTGAATGCCAGAGGAAGGAGCCAGGACGTCATCCCGAGAACAGCGGGCGGTGAGGTG
ATCAGATGTGGGTGTGGAAGCTGCCGGGGAGAAAGGCTGGAGCAGGGAAGATCCCAGAGGAGGTGGAAGG
AAGGAGGTGCCCAGCCCTGCCCCAGCCCCACCCTGGCTTCCTCACTCACGGTTCTCAAAGGGCTTGAAGT
CCTGGATGGCCATCACCCTCCATCGCACCCCCTCACGGCACAGCACCCTCAGGGTGACGATGTCAACTGT
GGTCAGTTTCTGAGACTGCAAGGGAAGGAGGGCAGGGGTGAAACTTCTAGCAGCTTCAGGCAGGGGAAGG
GGGAGGCCACCGGGATGACCTGGGAAGGATGGCAGCCTCTCCACATGCCCCGCCACCCAAGGCAGGGGCA
GCAAATGTTTTCTGTAAAAGGCCACATAGTAACTATTTTTGGCTTTATGGGGCCACATGGTCTCTGTCAC
GATGACTCAACTCCGCCACTGTAGTATGAAGCAGACGTAGGCAACATGTAAATGAATATTAGGGCCATGT
TCCAGTAAAACTTTATTTAGAAACACAGGCAGTGGGCTGGATATGGCCTATGGGTCAAGGTAGTTTACCA
ACACTTGATCTAAAATGAAGTGAGCTACCTTGAGAGGGAGTGAGCTCCCTGTTACAGGAGGCATGCAAGC
TGGTAAGCCCCCACAAAGGTACAGTTCTGGAACTATACCTGTTTAACATTTTTTAGTGTGAAAGGCCCTC
CCCTCCCCTATCTCTCCCCATCCCTACGCCTTGAATTTTCTGGAAGAAAATGGCCAGGTATTGAGCATTT
TCCTATGAGCAGTCACTGCTCAGATGCCTTAGCCCCTCAATGCACACAGCATCCATCCCATGGTATGGGT
GGGAAGCCTGAGGCTTGGGCTGGTCAAGGGACCTGCGCCAGGTCATGCAGATGAACAGCAGGGGAGCCCA
AGTTTAAACCCAGGCCCTCTGTGTCCCCCTACAGGGTGACTGCATCTCCGAGTCCTGGCTTGTCATGCCT
GACAGAGGGCTGCCGAGTGAGCAGCTTAAGGCATCCTGCCACTGTGCAGCTGCCAACCCTACAGCCCGGC
AGCCCTGCGGGAGGAAGCTCTAGTGCAGGCCTCTTAGGATCTGGGGTCCAGGATGCTGATTTCAGGGCCG
GGACCTTGGGCACCGTCCCTCTGGTCTGCATAAGACCCACTATGGGCAAACCTTAAACCTGATCGTTGGA
ATTCCCCAAACTGGCCAGTTCCTCTCCACCCTATAGACCCTGTCCTAGCCTTCTTATAGCTGCTATGGGG
GCTAGATTTTCCCCGATGATAGTAGTCTCATTATTATTATTATTATTATTATTATTATTATTATTATTAT
TACTATTATTGTTATAAAAATATTGCCAATCATACATTCGCGTGATCACTCACACTGTGCCGGGCACTCT
TGAGAGCACTTTACATATATTGTCTCATTTAATTCTCTCAACTTGGGCACAGGCACTGTCACTATTTCCA
TTCTACAGCTGAGGAGACTGAAGCACAGAGAGCCTTAGGGACTTGCCTGAGGTCACACAGCTAAGAAATG
GTGGAGCCAGGATCAGAAACCAGGCCACCTACAGAGCTCCCTGCAAGGGGAACAGCATCCGGTTCCAGAG
GCTGTGATTTTATCAGCTACACTGTGTGACTCCATCTTCACACTCTCCTGCCCCTCAAGAAGACATATAA
CCTGATGGAAGATGTGGTCCGGGTGTCCTTGGAGCCCGCTGCCGCCCAGGAGGCTTTGACAGACAATAAT
TTGATGTACACTCATATGGACATGGCCATATGCCCTGCAAGAGGCAGCCTAATGCAACGGTGAGAAGCCT
GAACTGGGAGCCCGCAGGCCTGGGTTCAATCCCAGCTGTGTACTTCCTGGCTGTGTGACCTTGGGCAGAG
ACCATACCTCTCTGAGCCTCAGTGTCTTCATTGGTAAGAAGGGGACAGTGCTGATGTTGACCCATGGGGC
TGTAGGTGAAGGCCGCAGCTGCCCATCCGGAGTGGCCGCTGCTAAAACTCTGGCTGCAGCCGGGAGGCGT
AGCTGGGGTCTCCTGCTCCACGGAGCAGGTAGGAGCCCTGCCCTCCCAGGCAGGGCTGCAGCTGCCTAAG
TCTTGGCTGTGGACCCAGGCCTCCTGGTGCTGTTGGGGGCTGGGATCAGGCAAGAGCCCCGCTCTCCTGG
GCGCAGCTGCAGCCACCCAAGTCGTGGCCACAGAGCCAGGTGTCCCTGCACTCTCAGGGGCCCTGGTCCA
AACCCAAGCCTCCAGGTGATCTTGCAAGCAGGGAGCACGCAGGAGACCCACCCTCCCGGGCACAGCTGCA
GCTACCCAAGTTGTGGCTGTGGACCCAGGCATCCCTGCACTCTCAGGGTCTGGGAAGATCCCCCCTTGCC
TCCGCAGGCTCAGAGCTGTCTGTTCCCACTGCTTGGCCTCTCCCCTGCTTCTGGCACCCGATCTGATCCT
GGAGGCACAGTCGGGGCTACGCACTCTGTGGATCCAGTGTGAGTCGGGGACAAGCGGGACCCCTGCCCCT
TCCGAGGTAGCCAGGAGCTCTCCTGGGGCAGCTGCAGCTGCCCAAGCCAGGACCCAGGCATCTCTACTGC
CCCCACAAGCTCAGGGGTGTCTGCTCCCACTGTCTGGCCTCCTCCTGCTCCAGTGCCCACTCCAATCTCA
GAGCGGGACCAAGCCCAGGCACTACCACAGCCTGGCACGCTCGAGGCAGCACTGACTCACTGGCCCCAGC
TGCCTCGGCCCCCTCTGGACTTTAGGCACCAATGAGCACAGGGGGATGGGAAGCCACGGGGGTGCAGGGG
ACAGCTTGGCACTGGCCTGCAGGTGCCCCTTGGCCCGAGCAGCCTGGGCAGAAGGAGGCGGGTCCCTGGT
GAGGTCCCACCTTCAGGCTGGGGAGGGCCTGAAAAACAAGGCCCTTGTTGGGCCTTGACCCAACAAGGTA
GGTGCCATTATTATGCCCATTTTACAGAAGGGGAGACTGGGGCACAGGGGTTGCCCAATGTCACCCAGCT
GGTGAGCCAGGGCTGGAGCATCCAGCTCCAGAGTCTACACCCTTCACCCCCCACACTGCACTGCACTGCC
AAGCCCCCGGGAAGAGCTGGGTGTGGTCATTACAGTTACTGGAGTGCTGTCTTACTTGATAAGGAACACA
AGTGTCACAGGACCCACAAAGCGCAGGGGAGACAGCAGGAGCAGAGGCAGAATGGCAGATGCCTCACATA
CAGAGGGTCCGTCGGCCCTGGGGCAGGCCTGAGTCCACTCCCTGGGGTGTCACCTGTTTTTCTCTGCCTC
TTGCTCAGCGCTGGGCATCCTGCTTAGCCACAGCCCCAGCCATTGGGCCTCAGCTCTTCCCCTGGCATCC
GGCCCACCCTGAGATCGCAGCCCGGAGCTGGGAGACCACCCTCTCCCTGCACTCTCTCCCTGGGTGGGCT
ACTCACATCTGGGGCTCCGAGGATCAGGTTGCAGGCCCAGGATGCTTGACTCACGGGGAGCAGCTCACAG
GTTTGGTTCCACCGCCTTTCATGGCAAAAGACCCTCTTTAGAAGAACAGGAAGGACCCACACAGCTGGCC
CAAGGGACTCTTCTCAGATCTCTCTGCTGCCAGGATGGCACCAGGCAGCAAGGCCAGGCTGGGGCCCCTG
TGCCAACCACTGTGAGGGGCACTGCCTCCCCCACTGGCTCCATGGCATTCCTCCCTCATGGGCACCTTGT
CCTGCTCCCTCATCCCAGCCTGGTCCCACGGCAGCTGGAGTGATCTAGAAACACAAACCACTTCAAGACA
GGCAGTCCTCCCCACCTAGAGCCCTCCAAAGCTCCATGAGGCTTAGGATGAAGATAGATCCTTAATTAGG
CCTTCAGAGCCGTGTGGAATCACCACCCACCCAGAAGCCAGGGCCCGAACCTGCCTTACCCCTCCATCTC
CCTCCCCATTTTCCCCCACCCCACACCCTATGGAATCCACCTGGGCCCAGCCACCTCTCTGTGGTCTTCC
TCTTCTCCCTGACCCCATCAAGCCTACCTGGGGTCAGTCCCTCACTCACTGGCCGCCTGGATGTTTACAT
CACAGTGACATCTCTCTCCCATCCACCAGGCACCCAAACCACTCCCAGGTTCCCTGTCCCCACAGCTGCC
TACAGGGTCTCTCAAAATCCGAGCTTATCCAAAAAGCTTGGGGACCCTCCTTTCTCCCCACTTCCTCTCT
GCTTGCCTCTAGAGTGGAGTCCAGCCTTGGCATAGCAGGCTTGCAGCTCAGTGTCCCCAAACTACCCTGT
CCAGTTCATCCCCAGCCCCTCCACTGCAGCCTGGACTCCACCCAGGTTCTAGAAGTCTAAATAGCTGACT
CCCAAATTCTCTTAAACGATCCCTTGATTCCAGGCCTGGGCCCCAACTCCTGTGATTCAAAAAGTCTGTG
GGTCCCATTAGTCCAAGATTCTGTAAACGTTGACTCCTTGGAGTCCAGTGCATAGGATCCAGAATATGAG
ATCCCACCATCCTAAGATTCTGCAGTGTGGCCAGTGGACTCACCGTCTGTCCGGCCAGGCATGGACTTGG
CAGGAAGTGTCCTGCAGAGCCCCATCTTGGCTCCAGACACAGGAGATGTTGGCTCTCGAGTTGTAGAAGC
ATGTGAACTGGGAAGTGCCTGCCGGGCAAGATGAGGTGTGAGTGCTGACTGTAGGTGCCCACAGCCCCCC
CAAGACACGCCCACTGCCCCTGCACCTGGCACCCACACCTGCCAGAGGAGGAGGTGGGTAACTCTGGCAA
GCGGAGAAGGGATTCATGGACCCACTTCAGAGAGGAGGAAATGGAGCTCCAGAGCCTGCAAGTTCCTACA
GGCAAACTAAGGCAAGGCAGGGACAGAAAGTAGCACAAGCCTGTGGCTTGGAGAGGCGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGTGCGCGCATTCATGCATGCATGCCAGGGCAGGGGTCCAGGACAGAGGGTG
AGGCAGGAGGTGGACACCTGGTCTCTGGCCCCATCCCCTTCTGGGAAGAGGCTTTAGCAGGGCCTTAGCC
ATCTCTCCATAGGGAAAGCAGAGCTGTTCAGATGTCAGGGTCCTCACCATTCACCGCTGCAGATGCCCAA
GAGGTAGCCAGGGGCAGGAGGAGGATGAGGAGGGGCAGACGCCAGGACAGAGCAGGGGCCGCCATTACAT
CCACAGGGTGGAGCCGAGGAAGGAAGCCCTGGTGGGAGAGGAGAAAGAGAGAGCACACGTAAATACACAT
CCCAGGCCTCGCTGCCCCTAGAGGCAGGCTGGGCCCGCCCCCTCAGTGTGCATGGTCTGCACTCCTCGGT
GCCAGCTCAGTCCAGCCCCAGGGCCTTTGCACCTGCTAATCCCACCACCCTACACATGCTCACACCCTTC
CTTCAAGTTTCTGCTCAACTGCAGCCTCCTTTGAGAGGTCTTCTTTGACTAGACTACATAAAGAAGCACC
CGTCGTGGCCAGGCGTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGTCGAGGCAGACGAATCACC
TGAGGTCAAGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATT
AGCCGGGCAAGGTGGTGGGTGCCTGTAGTCCCAGCTACTCGGGAGTCTAAGACAGGAGAATTGCTTGAAC
CTGGAGGCGGAGTTTGCAGTGAACCGAGATGGCACCACTGCACTCCAGCCTGGACGACAGAGTAAGACTC
TGTCTCAAAGAAAAAAATAAAAGAAGCACCCTTTGTTACTCACCACCCCCCTACATTTTCATCATAGCAT
TATTTATTCATCGTTTATTGACTGATTCATGTTTTCCTCTATCTCTCTTCACAAACACACACAGAGTCAC
GTAAGCTCACTAAGGACAGGTATTTTTGTGTTTTGTTCATTGCTAGGTCCACAATTCCTAGAACAGTGCC
TGGCACATAGTAGGCATCTGGCCAAAAAAAATTCTTGAACAAACAAGTGATGGAATAAATATAGACAGAG
CTAAAGTCAGCAGGTAGAGGGGCTTCCAGAGGGCTCTGAGGCTAGCCCCTGCCTCTGCCCCTCACTGTCC
CTCGAGGGAGCTGAGGCAATGGTGTGAAGGCATCAGGACGCGAACTCGGAAAAGCAGAAAAGCAGATAGG
AGCTCTGACCCAAACACTGAAGAGCCCTAGAGGACAGGGGAAACTGAGGCACAGAGGGCTGCAGTAGCCT
TTACGGAGGACCTTGTCCACACTCGTACTCCCCTACCTGCCTGGAAGCTCCCTGGAGGCAGGGCCAGGTT
GGTCACCCAGATTATACCCCAGGGAGGAAAGAGACATGAAATCTCTAAGCCAGCCCTGTCAGAGGGAGGC
TCAAAAGTTTTCCCGGAGTGCCTATTATGCACTGGCCACTGGCCAGTGCTTTATTTATTTACTTTTTTTT
TTTGAGACAAAGACTTGCTTCTCAGGGAACCTCTAGCCAACCGTGGAAGCTCCCGTGAGGCAAGACCACA
ACTGTCGCAGCGGAAATGGGAAAGAAAAGTAGCTGCCCCCACCCTCTGCAGGGGCTGGGTGTGCGGAGGG
GAATGAGAAAGTGAGCACATGGTCACTTCGGGAAGATAAGGGGACTGCTTCCAGGAGAGGTGTTTGGAGC
AGGCAAAGGGGGAGGCAGGGAGATGAGGAGGGAGCTTCCAGGGAAAGATGAGGGTAGCCTCAGTCAGAGG
GGCAGGGGGAGAGGGGAGAGGAGCAGGTGAGTCAAGAGATGTGGAGGAGGTGGAACATCCTTCCCTCCCT
CCTGCTCTTCCATCTCGAGAGCTTCCAAGGCTCCTGAGCGTTGGGCATTTCCCCCGCTGTTCCCCCTTCT
CCAGCGGCTCCAAACTCGAGCTCTCACTCCCCTTCCCTTCTCTCTCTTGAGCCTCTCACTGGCTCCAGCC
CTCAGCTTCCCAGGGTCTTTCTCCAGCTCAGCCCCAAGCCTCCACGTCCCTCCCGATGGTCTGCAGGACC
CCCTCACAGGGGATGCTCCTGGACCCGGCAAAAACCCAGCTCATCCCCAGCTCTTCTCCTGTCTGACTTT
CAGTTCTGGGACAACTGTACCCTTCCTATTCCAGGTGACCTTTGCCCCCATACCTAGCCAGTCAGGACTC
TCCTCAGACAGCAGGACACTCCAGTGACTACTTGTTGTCTCTTCCCCACCCTCACCAGGCCAGCCTCGTG
CCGTTCCAGCCCAGACAACGGCACCACCCCATCTGCAGGCTCTCACCTGCCTTCCCTGAAGCCCGCCTCC
AACCACCCACATCCCTGCCCAGGAACCTGCAGTGGCCCTGTTGCAATCAAAGCCTAAATTCCCATTTTCG
AGGCTTTCTGGGACCGGAATGAGGTCAGCCCACCCTTCCAGACCCTGCCCTCACAGGAGCAGGTGCATGT
ACCCAGGCCAAAGCACACACACACCGCACCTACCTGCCTGCACAAGCCAGTGGCTCCAGGTGACCAGGAA
ACCGACACTCACCCTCCAAAGGTCCTTCCCAAGTCTATCCTTTCCCTGGGTCCCCTACAGATCCTGCCAT
CCTTCAAGCCCATTTCAAACGGGCCCTCATGCCTTTTTCCATGAAGCCTTCCCTGATTTCCGTGATGGAG
GGCGAGGGCTTCCTCTTCTGAGCGCCTTGCTCCTCCCTCTAGGCTGGCAGCAGCAGGGCCGGCGTTGACC
AGGGGCTGGCCCACCAGCACACTCGCTCCAGGGACTGCTGAGCACAGGGCCGGGCACACAGTCGGTGCTC
AATAAATGTAGTGAAATGAATGAGTGTGGTCAGAGGCCTCAGTACGGCAAAAAAAAAAAAGCAGAGCTCT
TTAGGTGGCCCTGGATTGTCTCGTGGCTTACATCAGAGCCAGCATGGAGCAGGGACACACACCCTGGCCC
CAAGAGCCATGGGTTCCATCTCCTAAGGCAGATGTCACAGGAGTGAGAGTCAGAGGCCCACGCACTGTCA
AAGCTGCAAAGGCTCTCTGAGCAAGCACAGTCCCTTGTTCTACATTTGAGAACACTGAGGTCCCGAAGTG
GGAAAGACTTGCTGAAGGTTACATCAGGAGCCCAGCACAGAGCTGGGATCAGAACCCAACTCCACGCCGC
TCTGCCACCCCCTTAGTCACACCAAAACCATCGGCTGACAGGTTACTGTAAGCCAGGCTCCATTTAAAAC
TCTTTAAATGCAGCAATCAGGGCCTCTGGCGGGGATACTCTTATTATCCCCATTTTCCAATGAGGAAACG
GAGGCACACAGAGGTGAAGTGCGTTGCCTAAGGTCATGCAGTGGATAAGAGGCCTTTCTGGAATCTGAGT
CAGGGCAGACTGCCCAGTGCCCAGGCAGGGATCCTCCCCTCCTGGAACTCCCCAGACGCATCTTCCCACC
ACGACAGCTCACACGACAGTAAATATGCACTGGTGAACTAATAATACTCGTTCTGTGTACTGAGCACATA
CTCTATGCTAGGCCTGGGGCCAAGTGCCTCACATATGCCAGCTCGTCTAAGCTGCCCAATGGCTTTATTA
TCCCATTCTACAGATGAGGAAACTAAGGCTCCAAGCCCCTAACTTGCCCAGGGTCATAAACACAGTAAGA
GGTGGAGCTAGGGCTCCAGGCTCACTCTCTCATGCTGTCCCACCCTGCCAGACACTGGTCCCAGAGGTAA
GGCTGCCACCCTCTCTGTCCTGGGAGTCAGGACCCAGCAGCTCACAGACAGACTGGCAGGTGCTTATTCG
GGGTACCATGGGCTCGCCTTTGCCTGGCCTACCGTCTCCACAGGAGGGTGAGCTCCCCAGGGTGGGGGCT
GCTCACCTCTTTCTTGGGATCCCCCAATAGCAGAGGGCACAGGGTTGGGACCCCAAAGAGTGCATAGCCC
AACCAGGGGACTCCCATAGCCCCTATGCCCCTTCACGCTCAATCATGCCAACCTGGCCCTGGGGCAAGGG
GACCATCAATGTTTTGTGTGGGTGTCACCCCAGGTCGGGCCCAGCCTCAGGATGACCCCATGCCCAGGAC
AGGAACTGCAGAGAGCCCCAGTGTGTGAGGAAGGTGCTGAGGGACAAAGGGGTGCAAGGTCAAAGGAAGG
TTAGGGGTAAACCACAGGCCCAGCCTAGAGGCAGCCGGGCAGGAGGAGAAAGCGCCATCTGGAGTCTGCT
TCCCGCCGCCTGGAGCTCAGAGGTGCAGCGATGCTCGGAGAGGGCAGAGTCCACGGGAGGATGGTGTGGG
GGTGCCAGAGGGGCACAGAGCTGAGGGAGCGCCTGGCAGTCACTGAGGCTGCACCCTCATTCTGCAATGG
GGAAGCTGTGCCTCAGGGAGGCCAAGGAACCCACTTAAGGTTGCACGGTGAGGAGAAGCCCAGCCTCGGG
TGACAGCAAGTGGAGCCCAGGACCTCGAGTTTGAGCACCCCCTCCTGGGTCCTCAGGCACACCCACACGT
GCCCTGTCGTTCATGACTCTGAAACTGGTCACACCCACGGATGCCTACGTCCCCACCACAGCCCTGCAAG
GTGGGTCTTGCTGCCCCATTTGATCCATGCCAGAACTGAAGCCCGGAGCGGCTGACCCCAGCCATCTGAT
TTTCAGAGAGATGCTGCTGGGGACAGGGACTGGTGCCTGCTCTCTCTCTGCCTACACTGCCTGCCCTGAG
CGCTCGGGGGTAGTTCAGCTTTTAGCCCTCCCTACAGCCCCATGAGGAGGCTCTAGTATGCCTCCTTTTT
GCCAAATGAGGAGACTAAGAAACGGGTCAACCTCTCACCCAGGCGAGAAGGGCATAGAGCTGGGATTTGA
ACCTGGTCAGGTGCAGTTCGGGGCCCCTGCTGCCATCAGGGGTATATGGTGGCTGGGGCAGGGTGGTAAA
GCAGGAGCTCGGGAGCCCATGGTTCATCCAACTTGACCTCTGAACTCAATGGGGCCTATGTCCCCTCGTC
CTCTCTGGCCACCTCCACCTGCCACCCCCCTGCTCCCATACACAGTGCTTGTCTCTTGCTATTTAACTTC
AGGGGCTTCTCCAGCTGGGTGCGGGACCCTGGCTGTGGGGGAAGGAAGGGGACCCTTGGGGATAGCTCAG
CTCCTCACTCCACCTCCCTCCCCCGAGGTGCTACAAACACAGTTAAGAGTGGGAGGCTTCGGCCCCCAGG
AGAGGAGAGAGCATGAGCTCCAGGCAGCCCCAAAGATAGGGTCCCATCCCCAATGTCCGGAGATGCTTCT
GACCTGTCCAGTCATGCAGCCAAGGGAGGGACAAACCCAGACTCAAACCCAGGGCTCTGCCTCCAGCCTG
GGGCTCCCAGAGGCCTCGCAGCAACTTCACTTCATAGATGGCTCTCCAAGGGGACCCTTCTGTCCCCACT
TACTCCACAAGCCTCCTGATGAGCACGCAACACAGGGCTGCCTCCCCCGGTATATGGGCCCCACTCCACA
GAGGTCAGGAGGGGGCTCCCGCCTGTCCCACCCCATATCCCGTACCCTCTCCGGGCACCCAGGCTATCCA
CCCATCCCTTCTCCACCTCTCCGGGTTGGGGGCCCAGCACACAGAGCCCAGGGAAGCCCCTCATCCCACA
GCAGTCCCTAGCCTCCCCTGAATGGGTTGGGAAGGAGAGCTGACCTGGGACTGGGGACCGCTTTTTCCTC
CAGCCAGGAGCCATGAGAGCTGGGCCCAACCCCTCCCTAGGGGAATTCTAAGACAAAGTTGGGGGATGGG
AGTTCAGGCAGAAACTGCTGGGGGAACTGAGTCAGAGCTGAAAGTCTTCTCTGTGACTTTCACTCCCAGC
CCTCTGGCTGGTCCACAGGGGCCGGGAGGGAGGCAGGGGGACATCACCTGGCTGAGACATGGGGCGGTGG
CAGCGCGCGCTCTCCAGTCCTCCCCGGTGCTGGGACCGTGGCCATCTCTCCAGGGCCCTGCTGAGCTCTG
GCTGCTGGGGCCGCAAAGACTAAAAGCCCAGAGCCAGCCCACTTCCTGTGCAGAGGATAGAGGGGCAAGG
CCTGGGGTGGAGAGGCGGGGAGACGAGGCTTATGAGAAAGCCTGAAACTCCTCAAGCACCCAGGGCCAGA
TAAAGATCTGCCTCCTACGCTGGGGGCGGCACACACACACACACACACACACACACACACACACACACAC
ACAGACACACATTGTCAAATAGGGGCCTAGCTGCACACAGGAGCCAAGGGAACGCAGGCCCTCCCTCTCT
CCCCTCCTACATCACCCCCACGCCAACTCACACAGGCTACCCAACACCTCTGACGCCTCCATCCGGTCAC
ACACATACCCACTAATACGTAGGCTTCACACAAGCAGGTCCCTCTAGGTGACCCCAGCGTCTCACCCTCC
TCCCAGCCTGCAACACACCATCTTTCCGAGACTCCCATTTCACCCAGCCTTCCAGGAAGCCCCTTACTCC
GTTTAGCATTCAGAGATGACTGTTTTTTTTAGTTTTTAATTTTGTGGGCATGTGGTAGGTGTCTATATTC
ATGAGGCACATGAGCTATTTTGATACAGGCATACAATGTATAATAATCACATCAGGGTAAATGGGGTATC
CATCACCTCAAGTATTTATCCTTTCTTTGTGTTAAAATCCAAGTATACTCTTTTAGTTATTTTTAAATGT
ACAATAAATTATTGTTGACTAAAGTCACCCTGTTATGCTATCAAATACTAGATCTTATTCATTCGATCTA
ATTCTGTTTTCGTACCCAACAACAATCCCCACCCCTCCAACCCCCACTGCCCTTCCCATCTCCATCACTG
CCCTTCCCATTTCCATGAATTCAATTGTTTTAATTTTTAGCTCCCACAAATAAGTGAGAACATGTGAGCT
TTGTCTTTTTGTGCCTGGCCTGTTTCACTTAACATAATGACCTCCAGTTTCAAACATGTGGTTGCAAAGA
CAGGATCTCATTCTTTTTCATGGCTGAATAGTACTCCATTGCATATATGTACCACATTTTCTTTATTCAT
TCATCTGTTGATGGGCACTTAGGTTGCTTCCAAATCCTGGGTATTGTGAACAGTGCTGCAACAAATGTGG
GAATGCAGATGTCTCTTCCATATACTGATTTCCTTTCTTCTGGGTATATACTCAGCAGTGGGATTGCTGG
ATCATATAGTAGTTCTATTTTTAGTGTTTTGAGGACTCTTCAAACTGTTCTTTATAGTGGTTGTACTAAT
TTACATTCCCACCAACAGTGTACGAGAGTTCCCTTTTCTCCCCACCCTCACCAGCATTCATTATTGCCTG
CCTTTTGGATAAAAGTCATTTTAACTGAGGTGAGATAATATCTCATTGTAGTTTTGACATGCATTTCTCT
GATGATCAATGATGTTGAGCACCTTTTCATAAACTTATATGTTTTCTTTTGAGAACTGTCTATTCAGATC
ATTTGCCCAATTTTTGATGGGATTTCTATAATTTTTTTCCATAAAGATGTTTGAGCTCCTTATCTAGTCC
AGTTATTAATCCCTTGTCAGATAGTTTGCAAATATTTTCTCCCATTCTGTGGGTTGTCTCTTCACTTTGC
TGATTGCATCCTTTGCTGTGTAGAAGCCTTTTAACTTGATGTGATCTCATCTATCATTTCTGCTTTGGTT
GCATGTGCTGGTGGGGTATTGCTCAAGAAATCTTTGCCTAGTCCCATGTCCTAAAGAGTTTCCCCAATGT
TCCTTTTAGTAGTTTCATAGTTTGAGGTCTCAGATTTAAGTCTTTAATCCATTTGGATTTGATTTTTGTA
TATGAAGAGAGATGAGGGTCTAGTTTCATTCTTCTGCATATGGATATCCAGTTTTCCCAGCAACATTTAT
TGAAAAGACTGGCCTTTCCCCAAAGGTATGTTTTTGGCAATTTTGTTGAAAATAAGTTCACTGTAGGTGT
GTGGATTTGTTTCTGGGTTCCCTATTCTGACCAATGGTTCATTGGTCAATGCATCTGTTTTTACGCTAGC
GCCACGCTGTTTTGGTTACTGTAGCTCTGTGGTATAATTTGAAGTCAGATAATGTGATTTGTCCAGTTTC
ACTCTTTTTGCTTAGGATGGCTTTGGCTACTCTGCATCTTTTGTGGTTCCATATAAATTTGACGATTATT
TTTTCTACTTCTGTGAAGAATGTCATTAGTATTTTGATAGGGATTACATTGAGTCTGTATATTTCTTTGG
GTGGTATGGACATTTTAACAATATTGATTCTTCCAATCCATAAACATAGAATATCTTTTTATTTTTTGTG
TCCTCTTCAGTTTCTTGCACCAACGTTTTATAGTTTTCATTATAGAGATCTTTCACTTTTTTGGTTACGT
TTATTCCTAGGTATTTTATTTTATTTGTAGCTATTCCAAATGGAGTTATTTTCTTGATTTCTTTTTCAGA
TTGTTTGCTGTTGGTACATAGAAATACTACTAACTTTTGTATGTTGATTTTGTATTCTGCAGCTTAACTG
AATTTGTTTATCAGTTCTCATAGTTTTGTGGTGGCGTTTTTAGGCTTTTTGAAATATAAGATAATATCGT
CTACAAACAAGGATAATTTGACTTCTTCCTTTCCAATTTGGATGCCCTTTACTTCTTTCTCTTGTCTGTT
TGTTCTAGCTAGCACTTCCCAGAGATGACTATCAGGTCTTTGTGAACAATTTGATGGTCACTTACTGAAC
ATTCTAGAACCTTCCTCTTCCTCTCAAGTCATGGTTCCTAACCCTTCTCCCCCTTTTTTGGCGGGGGAGA
AGGGTGGCGTGGGAGCTCAGCTCAGGGCTCTTTTTTTTAAATGATGGAAACTTATGGATTGGTCTTTAGA
AAAATGCACATCTATTTACGTGCTACATCACAGCCCCATAGACCCTGTGAAGTTCCATCCTCAGAGCCCA
GAAGCAGCAGCTCTGCTTCTTCCCTTTCCTGATTCCCTGTTTCAGAGGGGTTTTATTGCAAGCTGTGGCC
TCTTTTTTTTTTTTTTTTTTTTTTTGAGACATAGTCTAGCTCTGTCACCCAGGCTGGAGTGCAGTGGCAC
AATCTCGGCTCACTGCAACCTCTGCCCACAAAGTTCAAGCGATTCTCCTGCCTCGGCTTCCCGAGTAGAT
GGGATTACAGGCACGTGCTACCATGCCCGGCTAATTTTTGTATTTTCAGTAGAGACGGGGTTTCCCCATG
TTGGCCAGGCTGATCTTGAACTCCTGACCTCAGGTGATCCACCTCCCTCGGCCTCCCAAAGTGCTGGGAT
TACAGGTGTGAGCCACTGCGCCCAGCCTGCCACCTCTTCTGAGAAGAAGAGAGAGAAGAGCAGAGACGGC
AGCTCTGCAAATGTGAGAAAAGTGGAATTCAAGACTCCAAAAAGAGAATCAGGCCCAACTCCCATGTGCA
AAGCCCGCTGCTGGAAAAGAAGAAGCGTGGAGCACTGCTGCCCAGGAGGGGCAGGACTGGAGATTGAGGC
TGTGACTTAGGCCTCCCTGTGCTTCAGTGTGCAGACCTACCAAATGAAGGGAGAACTGGACAAGAAGGTG
TGTATAAAGCATTTAATGTGACCACGCACTGCAGGCTTGCTGTAAGGGCCAGTTCCTTCCACACTGCCCT
TCCCTCTCCTCTAGAGTAAGGCTGTCTGGCGGCAGGAGAGGATACTAAACACAACAGCCACAACCATGAG
AATAACAGCCAACATTTATTAAGCCTCAAATATTCCCAGAAGCTTTGCAAGAAATTAGGAACGCCGGTTG
TCTCAGGGAGGAGAGCCAGGTGAGGAAGGGTTAGGAAGGACGCTTTTCTCTATAGACCCTTTTGTATGGC
ATGAACATATTTCCTGCCCCCAAATAAATGAATTCAGTTAAAACTTTAAAAGCACACACATACAAAGAAA
AGAAAAATGCATCCGCAGCCAAAGCCAGAAGTCACAGACCCAGCTTGCAAGGAGCAGCTGCGTACAGCTA
TTTCATCCATGAGACAGCATCAGTCTGCCTGGCACATACTGCCCAAGACTCTTCTTCCTCCTCATCCTGC
TTTCCTTCTTTTATTTATTCAACAAACATTTACTGAGCACCCCAGATGCCCCAAAGACCAGGTCAGACAC
AGGAAGCCTGAGGCGCGCAGCCCAGGCCAGCGGGGTAGGACCAAGGGAGGGAGGTAGGCCACTCTCCACC
CTCGTGCCCCTGAGATGTGCAGCAGCCAGGAAAGTGGGGAGCAGAATGGGGGATGGTGCAGCCCCCACAT
ACAGAGTCTCCCACCCCAGGAGACAGGGGATGGAGCCGGTTTGTTCTTTTGTCAAGGGTCCTAGCCCAGA
ACACCTCAGATGGAGAGGCAGGGAGGGGGCTACGCAGAGAATGATTCTCCTTCACATCCTCTATGTAACA
CCTCATGGCCTGTGGGAGCACGTAGGAGGGAAACCTGGTGGAATGGGTCCCCAGGCCATGGCGTGCACCC
TCCTCCCGGCATCAGCTCGGGTCTGCTTCCCAGCCTCCCTTGCAGTGAGCTGGGGCTCCAGAACCAAGTC
TGGCTAATGGGATGTGGGAGGAAGTGATTTATTCTACTTCTAGGCCTAAAAAAAATCTCACCTATGATCT
CCTGTGTCTCTTAATCCCTCTATCTCTCTTTTTTTTTCTTTTTTTTTTTTTGTTTTTTAGACGGAATCTT
GCTCTGTAGCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCATTGCAAGCTCCGCCTCCCCGGTTCAAA
CAATTCTCCTGCCTCAGCTTCCCGAGTAGCTGGGATTACAGGCACACACCACCACACCCAGCTAATTTTT
GTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCAGGACGGTCTCGATCTCCTGACCTCGTGATCTG
CCTGCCTTGGCCTCCCTAAGTGCTGGGATTACAGACGTTAGCCACCACGGCCGGCCATCCCTCTATCTCT
TTCTCTCTCTCCCCTCCCCTGCCAGAATCCAGTGAAGTTTTGGGTAGAGGGGCTGGAGTCCCTTGAAGGA
CAGGCCCTCACCCCTCCTCAGACAATTCACACTGGGCTATAACTTGAATGAAAAATAAACCTCTATTGTT
GGGCCTCTGAGACCTGGGGACTGCTGTTTCTGTTTTCTCTGACTCATACAGTCTGTCCCCCAGGTGCTAC
AGCTGAACATAAAACCAGGTGAGGAGGGGTGAGACAGTACGCCAGCAGAAGCCCAGAGGCATGGGTGGCC
AGCAGGGGTGTGCAGAGAGGTGCACCTGCTTTCTTCAGCCCCTGCCCTGCTCAGAGCCGTGTCATCTCCC
ACCTCAGCAGGCCCATGGTGGCCTCCGCCCTGGTCTCCCTGTTTCTATTAATACTCCTGACTCTCTGGTC
TGTTCTCCACTCAGCGGCCAGAGCAACCTTTCCCAAACTCAAATCACGTCATTTCACCCCCCAGCCACTC
CCCATCATACACACTCAAACCTTCCCAGTGCATTCACAGTAAAATCCAAACTCTCAGTCTTGACCCACAT
GTCCTACAGGGACTGCCCCATCTTCATCTCTGACCCTGCCTCCTGTGCTTTCTCACTCTGTCAGGGCTTT
GTGCATGCTGAGCCTGCTCTTCCCTTGCCATTTTACAGGCCAGGAAACCAGGCCTCATGAGTCATCCTAC
CAGAATGTGGCAGAGCCAGGATTAGAACCTAGGTCTGTCCCAGAGGACATCCGATTCTCTCTGAGGCAAC
CTGAGATGTAATCCAGAAGCTTCTCTGATGGCAGAGCCCTGACAGAGCCCACTCGGGCCTACCCAGACCT
GGGTCTCAGGAGTGCTGGGGTTTGGACCCAGCCTCCTCCACGAGCTCCACGCCTTGCTCCTATAACTACT
TCTCTTACGTCTTCCACATCCCCACCTGACCCTCTGCGCTGCATCTTCATGGGTCCCACTGGGAACAAAC
CGCCTCATACCCTCTGTTTCCATGCACCCAGTCCCACAGCCCTCCCACCACTGGACCCAGACCCCTCTTT
CACAGGGGCCATGGGACAAGGGCATATTGGGGTCTTCCAGCCCTGATGTCCTTGGGCTGTCTTTTTTGGG
GCCAAGCCAGACTGCATCCTCCTCAGTCCTGGTATCTGCCAAACGCCCTACCCGTCCTCCCTCTGCTCAC
TGGAGTGCTTGGCCCTTGCGCTCAGCCTCCCTCTCCACTCCGCCTCCCAGGAGATGTCAGGGTCCACACT
GTAGCCTCCAGCCTCCTGTTCCCTCTGAACTGCTCCATACCAGTCCCACACCCAGGCCTGCACTTGCACC
CTGCCATCATTCTGACCTGTGTTAACCAAGACCCCTTGAACTTCCACCTCAGCTCACCCGCGTGCTGCCA
TCACCGCCTCCACTGTACAACAGTGTCCCAGTTAGGATGAAGTTCAGCTGCGTGTGTCCAAAGAGAACAG
AAGAAGAAAACAGTGACCTAAAATAAGAGAGGGCTTTATTTCTCTCTTACATAAAAGAAGTCCAAAGGGA
GGCCACCCAGGCTAGGTGGGGTGGCTTTATGATGTCAGGATCCTGAGCTAAATCTGGCTTGCTACTAGGG
TCTCTTCAATATCCTTCTCCCATCTCCTCATAGACCAAGAGAGCTATTCAAGCTCCACCCATCACCTCTG
CGTTCCTGCAGATGGAAGGGAAAGGAAGGAGAGAGGGAGGGCTTGCCTCTGCCTGTTAAGGACCCTTCCC
CAAAGCTGCCGTAGCCACTTCTAATGTACATCCCATTGGCTACGCCTGAGTCACATAGCCAACCAAGCTG
CAGAGGAGGCTGGGAGATGTAGCCAGCTATAAGTAGAGGGCACACGGGCAGGGGAGAGCAGGTTTGGGGG
TGCCATTCACTGTCTCTGCCACCGCCTGTCCTCTGCCATTGTGAAGACCTCCAGTATCTCCAGGGCCACC
TCCCTTCCTGCCCTCCCTGGCTCAGCCAGCTGACACTGTCACCCACCCTCAAGTCCTTGTGTTCCGCCCA
CCCCTGCTCGGTGCTGTGACCTGTCTTCTGGAAAGTCAGCAGGTAGCCGAGTCCCCAGCTGGAAAAAAAG
TCCTGCCCCCACAGTGCCAGGCCTCACCAGTGACCTGGTTTTGAGTCCTGGTCCCTGGTCAGGAGGACTA
TGGTATACATAATTTGGTGTCTGACCCTCCGCCCAGTCCCCATCAGACTGTGGGGTACCCCTCATGACAA
ATGAGGATCACAAAGCTGCAGGGGCCCACAGAGGGGCCAGAGCAGAACAAGGAGAAAGAGCAGGCTAGCG
GCCGACTTCCTGAGGGCTGTCCTCCGAGCATGCCCCTCTGCTGACACCTGCTCTTCACTGGAGGCGCCCC
ACCCACCAGTCCCCAAGACAGACTGTGGCCATTCTCCCTGACTCCTTCCCTCCCTCACCCCCTCCTTCCA
AGCCATCACCCTTACTTCTGCTTTGCCACAGCAGCCACCTCCACGCCAGCCCCCCAGGCTCCAGACCTGA
AGCCCCACGTTCTTCCCTGTTCATCCGGGAGCTGCCTGCTTCATAGCCACACCAGCACCAGCGCCCTGAG
CAGCTCCTATCTTGTGCAAACCATGCCATTCCTTACCAGGATCGCGCCAAGGTGACCAGCTGTCCCACTG
TGCCTGGGACTGAGGGGGGTTTCCAGAACATAAGATTTACAGTGATATTCCTAGGACAAAGTTGGTCACC
ATATTCCCACCCTACTTACTCAGACTAATCAGCTCCCCGATTTAAAACCAGTCCTTCCCTGATCTCCAAT
TCTGGCCAAGGCAGATTCTGGGCACAAGCCAGTTACCATATCTCATGTCAGAGCCTTGCTTATGAGTCTA
CACCAGGAGCTCTTGGACAACAGGAACAGTGTGGGATTCATCCACACCACTCCAGAACCCAGAAAATTAC
CTGACATACGGACAGTGTCAATATGAGGGGAAGGAAGGAAAAAAGGAAAAGAGAAAGAATCAAAAGTGCT
AAGTCCCTAATACCCTGAAGAGTCCTGAGAATACACATTAAAAACACCAGGATAGCATATTTGAAGTTTC
AAAAGCTTTGCCATCAAAGGCAGGTTGAAAAGGCGAGTCACCCTGCTGGCGTGGGCTTCAAGCATCTCCC
TGGAAGGCAATCTGACATCTACCAACATCTCTGACACATGACCCAGCAATTCCACACCTAAAACTCATCA
ACAGAGTGACCCATGTTGAACACGTGTGTACAAAGTAACTCCTGCAGTCACGGGACCCGAGGCCAACAAA
ATGCGCATCCATAGGGGACAGGTGATGAGCAAATTAGGGAACTTCCATCCAGTGGAATGCCACGTAGCTA
TGCCAAGATAGGAAGGGGAGGGCTGGGCGCGGTGGCTTATGTCTGTAATCCCAGCACTTTGGCAGGCTGA
GGCGGGCGGATCACGAGGTCAGGAGATCGAGACCAGCCTGGCCAACATGGCAAAACCACGTCTCTACCAA
AAATAAAAATTAAAAAAAAATTAGCCGGGCGTGGTGGTGGGCACCCCGTAGTCCCAGCTATTCAGGAGGC
TGAGGCAGAAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCAACCGCACTCG
AGCCTGGGTGACTGAGCAAGACTCCGTCTAAAAAAAATAGGAAGGGGAGGCTCTCTGGGTCCTGATATGG
AGCAATCTCCAGGATGTACGGAGAAGAGACAAAAAACGAAGTTCAGAATACACGTGGGTGCACCACTGCT
CAGGTAAACATAAAGGCGGTAAGCCCTGTGTTCGAAGGCATGAGTGTGGCATACGTCTGTGAAGGTGCGT
GGGAGCATGTCTGTGAACTAGCATCTACCTGCACTGAGCCACTCAGGCAGGAATCCCTGGACACTGCTAG
CAGCCAAGTCCTCCAGCCAGTTTCCTACCTGAAACTGTCCCTGAGTCACCAGGCCCGTGGAACCACCCAT
CCTCCGCCGTCTTCACTATGCTGAGAGCACCCAGGGAGGAAAGCATTTTGTCCACAGCCACAACGCTGGT
TGGCAAAAAGGCGGACTCCTAACCCAGGTCTCCTCACAGCCAGGCCAGTGTCCTGTGATGGGGACAGTCA
AGAAAGCCAGTACCCACAACGGTTTCCGCTTTTCCTGTGGGAAACAGGTAGAGTGAAAACATTCTCTTTG
CTTTTTCTTATTCTTGGGCAGGTTTCACCAAAATCTGCGATCTTTCTCAGAAGACAATCTAGGTGTTGCT
GTGAGGAAAAAGGACGTGTGATGTTTGAAAAGTGTCTGTGAGAAGTTCCTCTCTATCAAGAAGTAACACT
TGCTTGCTTTTTTTTTTCTTAGTGTTTTTATTAAAGAATCGGAAAAAATTAAAATGTCCCTCTAAGAAGG
TTATGCCTGGCTGTCACCGTTGCCTGCAAAGTCTGCTTGGGGAAAAGCAAAAAATGGGGTCAGAAACATG
CTCTCACTCAAGAGTGACGATGCCCTCCGTCAGGCCTGGCACCAGAAGCGGCCACCCTGGGCTCGCTGAG
AACAGGGGACCCTGAACTCCTCCGAGCGGGAAAGATGCCCATTTCAGGAAGGGGGAAGGAGCAAGGCAGG
CTAGATCTGGGTATCACCTGGCCCTACAACATATATAGAGAGAAACTGTAAAACCTCTGCCTCTTGGTCT
CTGCCTCTTGGAGTCCTAGCATTTGTGTTCCATTACCACTTCAAGAATCTAAACAAGGTGAGGCCGAGGG
GACAGAGGCAGGTGCATTTTGGCAGATCCTGAAACACGCCACAGTGAGGATGCAGAGGAAGCCCTCCCCA
GAACGAAGGGGCTGAACTGAGCCTGCAGAAGGGAAGTTCTGGACTAGGGCAAAGCCCCCAAAAGTGCCTG
ACCAGTGACAAGGATTCATGGAGAAGGACCCCCCACTTTGGTTGGCACTCAGGGGTGCTGGCGTGGGGGC
CACCCGTTGTTATTCCCATGGTCCCTGCATCTGCAGCCCAAAGCCTTCTCCACCTGTGTGCTCACATAGT
GCCCAGCCTTGTTCCCAGCCAAGTTTAAAACATGATTCTCTTGATATCATTTCTGCGTATACAGGTTTGT
GGGCACATTGCGAGGGCCACTGCATTGTAAAGACCTCCTTGAGTAAATAGCATTTTTGGACAATCAACAG
TTAGCTAAAATATATCCTACTGTTGACCTCCCAACATCAAAGACTCTTCACATCCATGGCCAGAGGTAAC
CAGGCACACCCTTACTGATTAAGAACACAACACAACCCAGTGTCTGACTGGCCAGGACACTGATTGGCTG
ATGCAGTGACGGCAGCTCCCTGTGGGGAGCAGCGGGATGGCAGCTTATCCGTGGCTAAGGGAGCATCACT
GGAGTGTATGAGATTCAGCGGGGCCTCGCTCTTTCTCCAGGCAGGCCCAGTGGGTACAGGAGAAGGTGGG
GGCTAACAGAACCAGTACCACGCAGCATGATCACTAAGGAAGCCTAGTCTCTCCTTCTGGGAGGGTTTGG
GCAGGGAACTGAGATGCCCATGGGGGCCAGGTAGGAAGTGAATTTACATCAGGTGGACAGGTGGGGACCA
TGGCACATTGGAGACTCCAGCTACAGGAGAAATGGCAGATGGAGATGTCTGCACCATACTACCAGGAAAC
TCAATTTGCAAAAGAAGCTAAAATTGGTATTTTTAAAAACGTGAAAGGCCAAGGCGGGTGGATTGCTTGA
GCTCAGGAATTCGAGACCAGCCTGGCCAACATGCCGAAACCCTGTCTATGCCAAAAAAAAAAAAAAAAAA
ATTTAGCCGGGCATGGTGGTGCATGCCTGTAATTCCCAGCTATTCGGGAGGCTAAGGTGGGAGGATCGCT
TGAGCCTGGGAAGCAGAGGTTGCAGTGAGATCGTGGTGACAGAGCGAGACTGGGTGACAGAGCGAGACTC
AGTCTCAAAAAAACAAACAAAAGACTGGATGCGGTGGCTCACACCTGTAATCCCAGCATTTTGGGAGGCC
AAGGCAGGTGGATCACCTGAGGTCACCAGTTTGAGACCAGCCTGACCAACGTGGTGAAACCCCATCTCTA
CTAAAAATACAAAATTAGCTGGGCATGGTGGCACATGCCTTTAGTCCCAGCTACTTGGGAGGCTGAGGCA
GGAGAACTGCTTGAACCCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTG
GGCCACAGGCAAGACTCCATCTCAAAGAAACCAAAACAAAAAAACGTGAAAACCTCCCATTTAAAATACT
CGCCATTAATTCTAACTTAAACATGCAACAAAACTCCACCACCACAGCCGGCCCATATGTGAGGAAGCGC
CACTTTCAGAGGGAGGAGTGCAGCTGAGGGTGGCATTGACAAAGGGACCCTCTGCCAGCCCTGTTTCTTC
TCAGGTGCTGTCCTGGATATTTAGTTTACATCTGGGTGCGCTGCATCTTTGCAAATCTTTCTTGTGTTGG
AGTTATCTCCTTTTTTAGGAGTCTCCTACCCTAACCAGTAAGCTGAAACTGCTTTTCCAGCCTCCCTTGC
AGCTGGGACATAGGCATGTGACCAGGCTGCCCAATCAGAAGCCTCCATTCCAGACCTCAGGCTGGGAAAG
TGAGCATGTGACCAGGTTCCTTCAATCAGAAGCCTCAGCTCCAGACCTCAGGCGGGGAGAGCATGTGACC
AGGTTCCCCCAATCAGAAGCCTCAGTTCCAGACCACAGGCTGGGAAAGTGAGCATGTGACCAGGCTCCCC
CAATCAGAAGCCAGCTCCAGACTGCTGACTGGGAGGGCATGTGACCAGGTTCCCCCAGTCAGAAGCCTGG
GTTCCAGACCACAGGCTGGGAATATGATCATGTGACCAGGCTCACCCAATCAGAAGCCTCAGCTCCAGAC
CTCAGTCCTGAAGTGTGTGCGTGTGATTAGGCTTCCCCAATCAGAAGCCTCAACTCCAAGACCTGGAGGC
TGGCGAGGGTGGTGTCGGAACATCGTGTCCAGGATGCAGCAATTCTCCAAGCCTCTCCAAGCTTCTCCAA
GCTTCTCCAAGCCTGATTTGCGGGTCCTGCCAGAGATTCCTGAGCTTCAGAATATCCTGAATGATTCCTT
TTCTAATGACAGTAGCCAGTAGAGTTTTTGCAACTGAAGTTCCTGGCTGACACAGGTGCCTTAGCCAAGT
ACAGGGGCATGCATATATTTAGTACAGATCTCAGATTTGAAATAGTCTTTAATTACAGCAATGACTGACC
ACGTTGGGTGATGGCGATCGAGTGAGAGGGCAGCGAGGGGAAGAGTGCCCGCCCCCACGGTTTTCTGTCT
GCGGGGCCTTGGAGTAGGACCAGTGTTGTACCACAGGCCCTGGTGCCAGTGTGAGCATTGGATGCTCAAG
GACAGTACGGGAGGTCTTTGATAAAAACCTCCTCTGCCTAATGTACTGGTGGGGTAGGTGACCCAAACAT
GGGGGAGAGCTGACCCTGAGCTCACAGCCCACCGACTTGCTGGAAGGCTACCTAAATGCGCACTTGGAAG
GCCTGGTGAGGCCCACGCACACACCAGTTGGCTGGCTGACCTTGAAGCTGTCTTGCTAACTGGTTTATAC
TTCGGGTGACTGGTGAATAAAGAGGCTGCCAGAGCTTTCAGAACCAGCAGGGGCCCCCATGTTTGGTGAG
TGGCTGGTTTCACTTTCAAAGTGAGTTAGAGACAGTCCCACTGTGAAGCCTCTACCACACGGAGTCACAA
ACCCATTCTGGTTAGTCTGAATCAGGTCAGGCACAGGCTCTGTTTACCAAATCCCTGACCCCCACCCCAC
CCCTCTACCCCAGATCAGAGATCCTACCACATGCCAGGGGTACTGGGGAAGAGGCAGGGGATTGTGAGGG
CCAAAGGCTACCTGTCTGATTGACCGCATCCTACCCCTGCCTGCCTAGTTCTATACACCTCCTCACACTC
TGCCCAGCAGCCAAACCACCAACACCCACACCCCAGCACCAGACCATGAGATGAGAACACTCATTTCTTC
CCTTCGGTTCCACTTCATTTCAGTCCCACCCCTGTCCCCAGGCCAGAGGCTTCTCCCCAGGGGCATGAGC
ACTGGACTGAGGGTTTGGAGACCTAAGTTTGAGCCCCAGCAGTGCCTCCAACTCACTAGGGTCGCTCCCT
GCAGTCATCACTGCTCTGGAGCTACAGACCGCAGGAACAGGCTGTAGCTAACCTGAGCCAAACAGAACTA
GTTAGAGGATCTGGAGTGGTTCTCAGGTTCTGGAGGGAGCTGAAGACCCAGACCTCAGGGACGGGCAGAC
TCCAGACCAGCCGCACCTGCAGCTGAGTGTGGTCCAGCTGCAGAGACCCCTTTGAGGCACCAACCTCCAG
CTGTTTGCTGGCTTCATTCATTAGAATTCAAAGAGTCTCATTGGCTAAGATCACGTCAAATGCCCATCCT
CCAGCTGGAAAGGGTGGGGTACTTTGATTGAGAGTTCAACCAAGACTTCACCAAATGCAGGAAGGTAGAT
ACCCCAAAGAGAAATGGGGGGGCCGCTTCTAGAAGCAGGAGGCCTGATGCCTACTGAGCAAGCAGGAACC
AAAGATGCCCCGCAAGGACTGGCTTGGGTTGGATGATCCCAGAAGCTCTTCCAGGAAAGTCATCCTCTGA
TTGGAGGAATCCAAACTGGGCACCTTGCCTCCCTCAAGGGAGGAGGGACTCTTCTCAGCCCTTGGGAGGG
GCTCCTGGCATGAGGATGCCTTATACCCCCGCCCTGAGGCCCCCCATTCGGGGGAAAGCCAGGAAGGGTC
GGGGCTGCTACCTGAGTGGAGCAGAGGGATGCTCGTCTCCACCACCCACATGGGCTTGAGCCTGTGACCT
TGATTTCATGGGCCTCCGGGAACTCATGAGCAAACCTGAAAGCAGCAGGGGACGAAGGGCCCCAGGCTTG
TCACCCTCTTACTGGGCCAGGCTGGAGGAAACTGAGACCAGCTCATTCCTCAGTGCGTGGAGCTGCTCTG
TGAGAAACGGCCCCAAAGTGGAGCTCAGGTGGCAGCCAGCAGCACAGGCCGAGAGTGCCATGGCTGCTGC
TCATGCACGAAGGTGCTTTGCTGTTCCCACACCATTTCTGTGGGTTGCACATGGGACCTCTGGAAACAGC
CCAGAGGCCATCACCTGTATCACACGTGAGGGTGCGTGAGGAGAGGCGGCCTGCAGAGCAGAGCGGAAAG
CAACAGTCAGCCATGTAGCCTGTCAACACAGGGTTCTCCCTCTGCGCTCCCTGCCCCTCAGCCCCACTAC
TTCACCCCCAACCTCCTCCACCTCTCCAAAAGTACCCGAGAACCCCAGCCTCACTCCTCCCTAAGCCAGG
CGTCAGGGCCCAGAAGAGACCTGGCCAGTGCACAAGGGGTCAGAGGAGGGGAGCAGAGTGAGGAGGGGGC
ACGGGGGTGCTTTGATCGGGAGGATGTGGTCAGCGGCTTCAGGCCTGTGGTTTGAGCCCAGAGGTGCTGC
TGACACTCTGGCTGAAGTCATCTGTGCCGTTCCTGCATGAAGCAGTGTGGCAGGAGTGAGGGGTGAGGGG
CCGGGTGGTGGGGGTGGTGGGCAGGGGGGATGGTGGAAGCTGCAAGATGTGTGGTTTAAGTTGTGAAGCT
CACACCAAGCCTGGACATTCAGGTGAGTGGGCCGGGCAAGCCACCTCTCCCCACTGGGCCTTCTTCCTGT
TTCTCTCTCGCTTGAAATCACCTCCTGTCTGTCCCTTCTCAGGCCCAGAATGCAGACCACCAAGGAGGCT
CTGAACAGCCCACCTCAGAGACACCAGAGGCTCCAGCATCACCGAGGCTCCAGAGAGCAGAGGGCCACCA
GGAATGCAGAGGGCAGAATGCTACAGAGCAGAAAGTTCTAGAAGCATAGCCTTCCCAGGGAGGTACTAGG
TAACTCCTCTAGCCCTTACTACGCACCAGGCCCTATTCTAAGTACACATGTTGATTCCCGACTATGCTGA
AGGCAGTTTCAGGTTCAAGAGCATCAGCATTCCCTGAGAGCTGGTCAGAAATGCAGATGCTCAGGCCCCA
GCCCAGCCCTCCCGAGCCAGAATCTGTATTTTCACCACGTCCCCAAGCAACTCGAGTGTGCACAGAAGTT
TGAGAGGCCGCATGTTACCTCAGTGAATCCTGACAACAGCACTTGCAGACTAGGACTCTTATCCTATTTT
GCAGATGAAAAAACTGAGGCACGGGGAGGTTAAATAACTCGCCCAGGGCCGCACACAGGTAGGTGATAAG
TGTCAGAGATGGGATGTGGGCCTGGGCCATCTGGCTCCTAAGCACATGCTCCTAACTACCAGGCTGCCGC
CACCTTTGGAAGAAGAGAGCCATGAGAATTTGAGCTATGGCTGGCCGCATCTGTGCCTGCTCTGGCCGTG
TGCCTCTGGCCTTCCAGAACCCACTCTGTCCTTCCTAATGTTTCTCTGACCGTGGCCTCTCCAGGGAGAG
TCTGAATCATGATTTTCCCAGGCATGGAAGGTAGGAACACCTGCCAGTCAGCATGGAGCGTTTGTCAAGC
GTCTGTATTATCCTGGCTCAGGGCTGGGAGTTATAGCAGCCACAAAAGATGCCCAAGACTCCACCCAGCC
CTCAAGGAGCCCAGAGTTTAGCTGCAGGGACAGGAAATAGGCATGGGAACGAATGCAATATAATCACAGC
TAAAGTTTGTATGAGATGTGCAGATGCTCCTGGGCAGCTGCCTCTTCAGGGCAGGCTTCATGGAGAAGAG
GGCTTTTTTTAAAAATTTAATTTAATTTAATTTAATTTAATTTTATTATTGTTTGTGGGGTTGGGGGAGG
AGGGGAGAAGAGGGCTTTGAGCCAGGCCTACCCAGGGCAAGTGCCAGAAGGACAGAGGCGGGGAGGACAC
AGGTGCAGACCGGCCTAAAGCAGACACTTGGAGCTGAAAACATCCTGAATCCAACCGTCCACAACTCCCC
TCTACAGCATCTCCTCAAGAGGGCCAGACTCCCCTGAATTCTCCCTACGGCAAGGAAGTCATTCCTCGCC
AGGGGAGCGAGATCATGGCCTGTCTGGTGTGCACGTGTGTGTGTCTTTGCCACAGGTGTGTTCTTTCCAG
AACTCCTGTGAACAGGTGGGCCTCCTTTGTGCAAACCTGAGCCATGCACATCCAGCTCAGCTGATAGCTG
GGCCAGGAGAGGTGACCTCACCGCCCATGCTCAAGGTCTCTCTGTTGCACTGGACAGGGCCCCTCCAGCC
TTAGGCCCTTGAAGTCCTGGCTCCTTGGAAATGCCCCTGCTACTGGGGGGACCCTCAACTGCACCAAAGG
ACCGCAATGGAAAGGGGGCACTCAGCGCCAGAGCCTCCCCGCCCCCCCACCTCCTGCCGAGAGGAAGCCC
AAAACTGGCACATCCACACACACAGCCACACGCCCCCTTTGAAGGCACTGCACCGCTGCGTGTGTTGTAC
ACGGAGCCTGCGCTTCCTGGGCCAGAAGTGAAGCTAAGATGCACTCCACGCATTCAACCGTTGAACCCTC
ATTGCAGCCACCAGAGTTCTGTGCCACCCCTGCTCCGTTCCCGCGGTGGAGGGAGGACGCCTAGGCCTTG
GGAGGGATCGGGAGCGCGTAGAGTGACACCCTGGGCTCCACATCCACGACACCTTCTCCCCCATCTGGAC
TGCCCAACTACTTCATGCCTACCTCGGGACTTTGCATGCAAAAGGCGCTCAATCATCCCTTCAAGAATAA
TTGAGTTAGAAAACAGCAGGGCACAATGACAGGTGGGCCCAGAAGTTGCCACCAGAGGGCAGTGCGCGCA
CCTCCCCAGCCTCCTCGAGACTTGTGCTGCAGGAGGGAGGTGAAGTCGCGGCCAGGAGCGTGACCACGCT
GGACCGTGTCTGCTGCCTCCCCGGGAGTCGCAAGTGCCCACAGGACAAGCAGGGGAAGCAAACTGGGCCC
CTGGCTTCTGGGAAGACAGCATGAGGGCAGACCAAGGAAAGGCAGCCGAGACCAGCAGACCTGCAAGGGA
TCTCGGAGGCTCTCAGGCCCAGCTGCTTGCTGAATAGGTAATGATGCATCTGGGCCCAGAGAGAGGCAGC
TCTCAGCCTTAGGTCACACAGCAGGGCAGGAGTGTGAACTCTGGCCTCCAGCCTCCGAGGTCCCCTCATC
CCACCTAACCCCCAGACTCAGAGAAGGACACTCCACCCAAGCAATTTCTCACCTTCCCCTTAATTGGTAC
AGATCAGAAACGGGAGCACCTCCTTCTCCTGGCCCCCACGTTTAGGGTTCCCAGGACAGCCTCCGACCCA
CCCTCTGCCCCTCCTGTATCCCTTTCCTCGGCCCTGGGTGACAGCACCCCTGCCCAGACCAGCTCTGACT
GCCTCCAAGTGCCAAGCGCTCACAGTCCTCTACCCCCAGCCCCAGCCGGCACCCTCAGTCTCGTCCCACC
ATCTCTCTGCCTCCTGAGTCCCTCCCTGAGTCCCATGCCCTCTGCCCCAGCGACTGCCCTTGTAAAGTGA
AAATCCGACCCCACCCAACATTTCCTGCTGCACTTATGCAGTATCCAGGCCTCCTCGCCATGGAAAGCCC
AGGCCTGCGGCCTCTCTGGCTTCTTCTCTCCCTTGCCCCACTGCCCCTGGCTGTCTGGCAGTTCCTGGAA
GTCTCCAAGCTCTTCCCTGCCTCGAGCCCCTGCCCACGTTCTCTCTGCCCCAGGCCTCAGCCTGCGGTCA
CTTTCTCAGGGCAGCTTTCCCAGCACCCCGTGCATCTAAAGTGGATGCTGCCCTGCCCATCACTGGATCA
GGTGCTCATATTCCTAATTGACTGGGCATAGGTGGGAGGATTTGCCTGGTGTCTGTCTTCCTGGCTGGAC
TGCGGTGCCTCAAGGCCACAGGTGAAGTGCATGGAGTCCCACAGCTTCTCTGAGCCTAAAGCTTTGTGTG
ACAAATGCATTCAAACTGCATTTATTGAAAGATGGGAAGCAAGGGAGGAAGGGAAGGGGTGCGGGAGGGA
GGGAGGACAATCTTGGTGTTGGGCTGAGGTGGCGTCTGTCCCCTTTGCATGAGTTCAGTAAGGATTTACT
GAGCACCTGCTGGCAGCAGCATGCTGGGCACTGTGGGAATGACAAGGATGTGTGGGATTTGAACTCTAAC
TCAGAGTACCTTCTCTTGGTATGGAGGTAGGACAAGTATGCAAATGATTATAACTAAGGAAATCGTGTCA
ATGTGGTGACCCTTGGCCTGAACTTTCAGAACAGTCCTGGTATCACGTGAGAAGAGTAAATACATGTGAT
TTGATTCTAAACTGGCTAAGACGTTATTAAAGAAAGTAACAAGACAGAAAAAATACTTTTTCAGGCTGTC
TGTGCAGTTTTGTCTTTAGAAAATGTGGTCATAATGAGTATGAGAGGCATAGAGCGTGCCCAGTTTGAAA
CGCCTGCAAATGACAAAACACAAAAACACAAACCCAAAAATAGAACGTGGCTTGGCTGGAGCCATAGGGG
AGGCTCCAGAGGATGTGGCATCGGTGCTGTGGGCAGTGGGTCATTGTGCAAAGGCAGTGAGGGCTGGGTC
CCCATCCCACCTTGGCCACTTCCTAGCTGTGTGATCTTGGATAAGTTCCTTTACCTCTCTGAGCCTGTTT
CTGCATCTGAAACATGCGACTACTCCCCACCTCTTAGGTTCATGGGGATGGCATGAGATTGTGCACACAG
AGAAGCCATCACCCACAGTTCCTGGCATGCAGGAGGCACCTGAGGAAGGCTGGGTTCTTCCTCTTCTCTG
GGAGGATGGGGATGAGTGTTCCATAGGCCGGAATGGGTCGAGAGAAAGGGCCCAAGACAGAGGGAGCTGC
AAGAGCCAAGGCACAGACTAGGTGGCTGAAGGCAGTTGGGGAACAACAATTATCACCAGAGCCTAATATT
TCCCCAGCTCCATCTCCTTCCCTCCACGCCCAGTGCCAGAGGGGCACTGCTTATATAGGGGTTCTGCTTA
CAGAGGGGTTCTTGCTTACAGAGGGGTTCTGTTTACAGAGGGATGCTGTTTACAGAGGGGTTATTGCTTA
CAGAGGGGTTCTCGCTTACAGAGGGGTCCTTGTTTACAGAGGGATGCTGTTTACAGAGGGGTTCTTGTTT
ACAGAGGAGTTCTGTTTACAGAAGGGTTCTTGTTTTCAGAGGGGTTCTTGCTTACAGAGGGGTTCTGTTT
ACAGAAGGATTCTTGTTTTCAGAGGGGTTCTTGCTTACAGATGGATTCTGTTTACAGAGGGGTTCTTGCT
TACAGAGAGGGGTTCTTACTTACAGAGGGGTTCTGTTTACAGAGGGGTTCCTGTTTTCAGAGGGGTTCTT
GCTTACAGAGGGGTTCTGTTTACAGAGGGGTTCTTGCTTACAGATGGATTCTGTTTACAGAGGGGTTCTT
GTTTACACGTTTACAGAGGGGTTCTTGTTTACAGAGGGGTTCTTGCTTACACAGGGGTTCTGTTTACAGA
GGGATTCTGTTTACAGAGGGTTCTTGCTTACACAGGGGTTCTGTTTACAGAGGGGTTCATATTTGTTAGC
GGGACGCTGCCATGTCATCCTTCACTCTGCATCCAGAGCATCCTTGCACACAACTCTTCAGGGGCTCCCC
ACTGCCCTCAAGACCCTATCCAAGCATCCTGAGTCTGGCTTCAAGGCTGTCCCTAACTGGGCCCCCTCTT
GAAGATCCCCCTTTGCATCCAATCCTCTGGCCACACAGAACGCAGAATCGCTTGCATGCCTCCCCCTCCT
CCCAGGGTTTGCCCCCTCCCTGCCCTGCATGTGGCATCCTTCCTTTGCCTTCTTATCCCGCGGACTCATC
ATCCTTCAGGCCCCGGGTTCACATCCTCCGTGAAGCCTCCCAGGCCTTTACCCTTGCTTTCTGATGGGGT
TAGGTACCTGCCAGAGGCCTTCCTTCTCTCCCCAACTAAAGTGGGTGCTCCCCAAGGGCAGGAACTGAAT
CCCATTCATTCTGCATTTCTTTATGCTGCCTGGTATGTGCCTGGAGCATAGGAGGTGCTTAGTCATTGTG
ATGTGGATAGAAGGGTGGTTAATGGGTGAATGGAAAATGGACTGATGGATGAACAGAAGAAGGATGAATG
GGGGGATCATGGAGGGAATGATGGAGGGAGAGAAGGAATGATGGGGGAGAAGGAAGGAAGGATGGGGGAG
AAGGAAGGAAGAATGGATGGATGGATGGATGGATGGATGGATGGATGGATGGATGAAGGGATGAACAGAC
AGACGGATGGACAGACAGTGGATGTGGATGGACAGAATAATAAGACTCTTTCAGGAAGGCCAGAACACAG
CAGAAAGGCCCTGAAGAAAACCAAAGCAGCTGCAGGAAGTTTGGTGTTTGCCAAGGTTGGGGGTGAAATG
AGCTACCTGTTTTGCAGAAGAGATGGGGTGTGTTTTAGCAGCTGACATCACAGAAGGTGCAGGTCCCAAG
ACCTAACAGGAGAGCAGCTGAGAAGAGCAACAGCTCCTCATAGACAGGGATGGACAAGCTAGGCCAGCAG
CGGGGGCAGACTCTGCACTGTCCCCGCTGCCCCCAGCCGTGGAGAGATGCGTGTCTGCCACAGGGGAAGC
AGCGCCACCCAGGGGCTGGGGTAATGACAGGCGTGGCCTCTTGGGGGTGGACAGTCTAGAACCCAAGCCT
CCATCCCTCTCTGTGGAGGCATCATGGGAGTCGACTTGCCCCTTCTGGCCACCTCTCAGTCCCAAGGGTG
CCACATTTGGGGTTCTCCACCACGCAGTCACTGCTTGACGTGGCTCATGGCCTCCCAGCCTCACTGCACG
GGCCACACACACTTCCCTCAGTTCCTTTCCTCATTGTCTCCGCAAACACACAGATTCCTGCTGCCTTTAA
GACTTTACTGCTGATCTCCAAAGAGATGAAGCAATCTCAAAGATAAACATGAAGCAAATCCAAAGAAATC
CTGCAAAATTCTGGGAGCGCCTTTCTGTGGTTGGAAGCTGGGCACGTGGTGGGATGATCCTGCCAGCCTG
TGGAACTTCCGATATTATGGATGAGGGTGGATTTTACTACCTCCCAAATTCTAGGACTCACGCTCTTTTT
TTTGGGTGGGGAGGGGGACAGAGGCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTC
CCTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGACTACAGG
CGCGGCCACCATGCCTGGCTAATTTTTGTGTTTTTAGTAAAGACAGGGTTTCACCATGCTGGCCAGGCTG
GTCTCAAACTCCTGACCGCAGGTGATCCACCCACCTCGGCCTCTCAAAGTGCTGGGATTACAGTTGTGAG
TCGTCATGCTTGGCCTCACGCTCTTTCATTCAAATAATATTTATTGAGGAGCCCCTATGTGCCAAACCCT
TTTTCTAGAGGCTTAGGACACAACAGTGAACAAAACAAAGACGCCTGCCCTTGTGACGCTTACAGTCTAG
TGGGGAGTGGGGTGAGAAACAGACAATAAACATAAGGACTAAGTAAGTTTCATAGGAGGTTAAAAGATGA
AAAACGCTATCAGAAAAGAAAAAATGGGAGACAGAGAATCAGGAGCACAATTTTAAACAAGGCAGTCAGG
GTAGATGGACCTCACCAGAAGGCGATGGGAAAATCTGAAGGAAGGAGGGAGCCAGGCAGAACTGGAGGAA
GGATGAAAACTATGGAATGCTTCCTGAATATGCGAGGCAATTTATAACTCCCTGAAATGTGCCACATGAT
TCCCAATGCATGCCTTTGCCTACGCTAGACTGCAAGCTCCACGTGAGAAGAGACTGCTTGACTTGTTCTC
AGAAAGTATTTATGGGATTTATAGATGCAGTTGTACAGAATAGAAAGCTGCTCACAATCCTCTTCTTCAC
CTTTCCTCCTAGAAAACTCCTACACAGCCTTCAAGACCCAAACACATATGGGCAGAGTTGGTTGCTCCTC
CTTTGAGCTCGCTACTCTTGCACCTTATATAAACCTCTTTTATAGCCCCAATACACTGTGTTTCCCTCAT
TTTACTGCGGGTCAGAGCTTTCCCCTGGGTTGAGAACCCGCAAGGGGATCTGACCTGTCTGAGCTATTTA
TGGATCCCCAGAGCTCCTGGGACAGATGCTCGGCTGACGTTGTCAGGATTGAAATGACCTGTTACTGCTT
TAATGCTCCCTCTCAAGTAGGTGGTTTGCATTTCTGGGACCTTTGGCACCTCAGTTGAGGCTCTCTGGTT
GTGAGCAAGAAAACTCAACTATTAACTAAAGGTAAAGTAAAAAAAAAAAAAAAAAAAGTGATGTTGGGGA
TGGAGGCAAGGGGCTAGAGCCCCAACCAAACCTGCAGGAAGGAAAAGCCAGGGTAGCCCCAGCTCCTTGG
CGCCCGCTGTGCTTGGGATCCCTGGCTGCACCTCCTAATGCACTCGGCTCCATCAGCTCCTGGCTGCGGT
CCTGCTTCCCAAATCTGCAGAGCAGGACTCAAGCTGGCCCTGCTAGGGTTGGGGCCTCCCTTGGAGCCGT
CAACCATCCAATAGGGCCCAGAATGAGGTAGAGAGATGAGCCCAAGGGTGGGGTAAGGGGCTGAGGTTTT
GGGGGTGGGCAGTGGCGAGGGGTCCCTGGAGAAGAGGGGAACTTGTGAGCCTGGGGCCACACCCAAAGTG
CCTCCTTCACTGGGCCCAGCCCCCACCCAAGCCGCATTTCTAATGAAGGCTTTGTTTTGTAAGAATTTTT
AAATGCTTTAACTAGAAATTGGCAAACTGCAACATCTGCCAATTTCTAGCAGTATATATCCTGCCACCAT
GACCCATTTCAAGCTAGCATCGTGATGTCTCTGAACCTGCGATCGGGAAGACATGCATGCAGTCGGCTCT
GGTGCAAGCTGGCTCCAGCCACCATTGGCTGTGGGGCTGAGGGCACAAGCCTCCTCATAGACTCCTGTAA
GGAGCCCTGCCCTGTCTTGAGAACCACCGAAAGAGCTAGAGAGTGTTTCCCATCCTCCAGCCATCCTCTG
AGAAGTCATAGCTCAGGTCCTGGATGAGCCTCCCCTCTTTCCCAGGAACCATCCCTTCCTTCTGGTGTGG
CCCACTGGACAAGATCGAATATCCCAGGTCCTGCAAAACCTGGCTCCTTCCGGCCTCTGGGTCTTTCTTT
CAGTTCCTGGGAGGGGCTGAGCAGCCTCCTACCTCCTGGCCTTGACCCATATTGGCCCCTCCACCAGCTG
TGCTATGTCTCTCATCTTTGGGTCTCAGCTGAACCACCTCTTCCTCAGAGAGGCCTTCCCTGACCACTTC
TCCCTCCCAAATTTGCTTCTCCCTTGCCAGCACTTACCCCACGCTGAAGCCCTGCTGTGACTGTGTAATG
TCTCTCTCCCCTATTAGACTGGAAGCCGCATGAGGGCAGGGACCATGTGGGGTTTTGGCTCACCACACTG
TCCCCTGTGCTTAGCACAGGGCCAAGCCTATAGAATAGGAATCAATCCATAATTATTGATTGGGTAAACA
AATGACACATGAAGGAAGGAAATTAATCAGTTTTTCTGTACTTCACAGTTTCTTCTTCTGTAAAATAAAT
ATAAGAAAGTGTCTACCTTAAAATAATTTTTAACATTTATAGAGCACCTCCTACGTACCAGTATTTTACA
TATACTTACTCCTTTAATCCTCACAACAGCCCAGATAGTGTTAATATCATCCCCATTTTACAGGTGACAA
AACTGAGGCACAGAGAGTTTCAGTGACCTCCCCTCATTTACTCAGATTTGAACCCAGGCAGTGCCTCCAG
CAGCCTCAGCATTAACCACACACTAAACTGCCAGGGGGGGTTGGGGAGGGGTCCTGGAGGTGGTAGCTTT
GGCGCTGCTGTAGCCCTGCTGCCCCAAGAGCTTGAAGCCTCGTGAGCAGAGCCAACTATTGCTAAACACT
ATAACCAGGGGACGCTCAGGGATCCAGCTGCCTCTCACATCTGGGAAGATTTCCTGGAACCAAGACACCC
TGGCTGAGTCAGGCACCCGCATCTGACAATATGGCCAGAGAGTTTTTACGAAATGTGAACCAACTGGACT
CTCAACAGCTTCTCCCCACCCCACCCCAACCTGTGAGTGGGACTCTGATCTTGCCTGGGGCTCCAGCCCA
GCCCCTCAGGGTTCAGGGGTAAATCTCACTTCCCCGAGGTTGGGTTAGGTATGGTTATGTGACCAGCTGT
GGCCAATGAGAAGCGAGAAGAGGCTTTTGGACAGAAGAATCTCTGATTCTCTTTCACCCACCCTTGCCAC
ATCCATGAAACGGAAGGGTTCGTCGCTGGGTTTTGAGACTTTTTTCCATGAAGCTGAAGGCCAAGGGAGC
TGAAAGCCTTGCCACTGAATGCTGAAACAACCTTCACTGGCTACTTTAGAGATAACATTCATAGGTCACC
ATGGTAATGGTGGCTTCGGTTGTTTTTCAGGAATTGGGCCAGCTGAAACCAGTTGAGACCCTTCAGCTGG
GGAACCGTATATGTGCCCAAGAGATGGCCATTTGATATTGGAGGACCAAAAGCACCACGCTCAGATCAGG
CCAATGCATCTGTTTTCTGTATGTGTCCTATGAAATGCCATGAACCCCAACTATGCTTGTACAGAACAAA
CCGGTTACGTCATTCTTCCCCACTGCCAATCACCTGTCCCCACACCTTAGATCACCCCACTTCTCTAACC
CATTCATATCCCTAAACCTTGTCTTTGGGGAGGCAGATTTGAACGCTGTTCTCCCACCTCCTTGCTTGGC
AGGCTTGTGAATCAATCTTTTCTCTTTTGCAAATCCCAAGTCACAGCGATTGGCTGCACACTGGCAGAAC
AGATTGGGACCTGGCGGGTGATACCCAGATATGACACCTGGACCCAGAACAGAAATCTCATGGCCACCAT
CTTGAGACTGCCATCCTGTGGCCCTGAGGGAAGCTGGCTGTATTAGTTCGTTCTCACACTGCTATGAAGA
ACTGCCTGAGGCTGGATAATTTAGAAAGGAAAGAGGTTTAATTGACTCACGGTTCCACATGGCTGGGGAG
GCCTCAGGAAACTTACAATCGTGGTGGAAGGCGAAGGGGAAGCAAGGCACCTTCACATGCTGGCAGGAGA
GCGAAGTGCAGAGTGAAGGGGGAAGGGTCCCTTATACAACCATCAAAACTCGTGAGAACTCACTCACTAT
C
|
| Protein Name |
IL2RB_HUMAN |
| Length |
551 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-APR-1990 |
| Definition |
RecName: Full=Interleukin-2 receptor subunit beta; Short=IL-2 receptor subunit beta; Short=IL-2R subunit beta; Short=IL-2RB; AltName: Full=High affinity IL-2 receptor subunit beta; AltName: Full=Interleukin-15 receptor subunit beta; AltName: Full=p70-75; Short=p75; AltName: CD_antigen=CD122; Flags: Precursor |
| Primary Accession |
P14784 |
| Accession Version |
P14784.1 |
| Other SeqIDs |
sp|P14784.1|IL2RB_HUMAN,gi|124321 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Mar 15, 2005 this sequence version replaced gi:88015.; [FUNCTION] Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185). {ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:31040184, ECO:0000269|PubMed:31040185}.; [SUBUNIT] Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. {ECO:0000269|PubMed:12200137, ECO:0000269|PubMed:16293754, ECO:0000269|PubMed:16477002}.; [SUBUNIT] (Microbial infection) Interacts with HTLV-1 accessory protein p12I. {ECO:0000269|PubMed:8648694}.; [INTERACTION] P14784; P40933: IL15; NbExp=3; IntAct=EBI-2866779, EBI-980274; P14784; P60568: IL2; NbExp=5; IntAct=EBI-2866779, EBI-12508717; P14784; Q15645: TRIP13; NbExp=3; IntAct=EBI-2866779, EBI-358993.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:31040184, ECO:0000269|PubMed:31040185}; Single-pass type I membrane protein {ECO:0000255}.; [DOMAIN] The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; [DOMAIN] The box 1 motif is required for JAK interaction and/or activation.; [DISEASE] Immunodeficiency 63 with lymphoproliferation and autoimmunity (IMD63) [MIM:618495]: An autosomal recessive disorder characterized by immune dysregulation resulting in lymphoid proliferation, dermatitis, enteropathy, autoantibodies, hypergammaglobulinemia, and immunodeficiency with recurrent infections. Patients show increased susceptibility to viral infections, particularly cytomegalovirus disease. {ECO:0000269|PubMed:31040184, ECO:0000269|PubMed:31040185}. Note=The disease is caused by variants affecting the gene represented in this entry.; [SIMILARITY] Belongs to the type I cytokine receptor family. Type 4 subfamily. {ECO:0000305}.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/il2rb/'. |
| Source Db |
UniProtKB: locus IL2RB_HUMAN, accession P14784;; class: standard.; extra accessions:B2R765; created: Apr 1, 1990.; sequence updated: Apr 1, 1990.; annotation updated: Oct 12, 2022.; xrefs: M26062.1, AAA59143.1, CR456506.1, CAG30392.1, AF517934.1, AAM54040.1, AK312860.1, BAG35712.1, AL022314.1, CH471095.1, EAW60144.1, BC025691.1, AAH25691.1, A30342, NP_000869.1, NP_001333151.1, NP_001333152.1, 2B5I_B, 2ERJ_B, 2ERJ_F, 3QAZ_B, 3QAZ_E, 3QAZ_H, 3QAZ_K, 3QAZ_N, 3QAZ_Q, 3QAZ_T, 3QAZ_W, 3QAZ_Z, 3QAZ_CC, 3QAZ_FF, 3QAZ_II, 4GS7_B, 5M5E_B, 6E8K_B, 7S2S_B, 7S2S_D; xrefs (non-sequence databases): CCDS:CCDS13942.1, PDBsum:2B5I, PDBsum:2ERJ, PDBsum:3QAZ, PDBsum:4GS7, PDBsum:5M5E, PDBsum:6E8K, PDBsum:7S2S, AlphaFoldDB:P14784, SMR:P14784, BioGRID:109775, CORUM:P14784, DIP:DIP-43N, ELM:P14784, IntAct:P14784, MINT:P14784, STRING:9606.ENSP00000216223, ChEMBL:CHEMBL3276, DrugBank:DB00041, DrugBank:DB00074, DrugBank:DB00111, DrugBank:DB00004, DrugCentral:P14784, GuidetoPHARMACOLOGY:1696, TCDB:8.A.152.1.1, GlyGen:P14784, iPTMnet:P14784, PhosphoSitePlus:P14784, BioMuta:IL2RB, DMDM:124321, jPOST:P14784, MassIVE:P14784, PaxDb:P14784, PeptideAtlas:P14784, PRIDE:P14784, ProteomicsDB:53083, ABCD:P14784, Antibodypedia:11905, DNASU:3560, Ensembl:ENST00000216223.10, Ensembl:ENSP00000216223.5, Ensembl:ENSG00000100385.14, GeneID:3560, KEGG:hsa:3560, MANE-Select:ENST00000216223.10, UCSC:uc003aqv.2, CTD:3560, DisGeNET:3560, GeneCards:IL2RB, HGNC:6009, HPA:ENSG00000100385, MalaCards:IL2RB, MIM:146710, MIM:618495, neXtProt:NX_P14784, OpenTargets:ENSG00000100385, Orphanet:85410, Orphanet:85408, PharmGKB:PA29829, VEuPathDB:HostDB:ENSG00000100385, eggNOG:ENOG502S0MR, GeneTree:ENSGT00510000049239, HOGENOM:CLU_035782_1_0_1, InParanoid:P14784, OMA:QTSCFTN, OrthoDB:1322475at2759, PhylomeDB:P14784, TreeFam:TF337874, PathwayCommons:P14784, Reactome:R-HSA-5673001, Reactome:R-HSA-8983432, Reactome:R-HSA-9020558, Reactome:R-HSA-912526, SignaLink:P14784, SIGNOR:P14784, BioGRID-ORCS:3560, ChiTaRS:IL2RB, EvolutionaryTrace:P14784, GeneWiki:IL2RB, GenomeRNAi:3560, Pharos:P14784, PRO:PR:P14784, Proteomes:UP000005640, RNAct:P14784, Bgee:ENSG00000100385, ExpressionAtlas:P14784, Genevisible:P14784, GO:0009986, GO:0005829, GO:0005768, GO:0009897, GO:0005887, GO:0005893, GO:0016020, GO:0005886, GO:0004896, GO:0042010, GO:0019976, GO:0004911, GO:0019221, GO:0035723, GO:0038110, GO:0030101, GO:0043066, GO:0050766, GO:0065003, GO:0007165, CDD:cd00063, Gene3D:2.60.40.10, InterPro:IPR003961, InterPro:IPR036116, InterPro:IPR003531, InterPro:IPR013783, InterPro:IPR040951, Pfam:PF18707, SMART:SM00060, SUPFAM:SSF49265, PROSITE:PS50853, PROSITE:PS01355 |
| Sequence |
maapalswrlpllilllplatswasaavngtsqftcfynsraniscvwsqdgalqdtscqvhawpdrrrwnqtcellpvsqaswacnlilgapdsqklttvdivtlrvlcregvrwrvmaiqdfkpfenlrlmapislqvvhvethrcnisweisqashyferhlefeartlspghtweeaplltlkqkqewicletltpdtqyefqvrvkplqgefttwspwsqplafrtkpaalgkdtipwlghllvglsgafgfiilvyllincrntgpwlkkvlkcntpdpskffsqlssehggdvqkwlsspfpsssfspgglapeisplevlerdkvtqlllqqdkvpepaslssnhsltscftnqgyfffhlpdaleieacqvyftydpyseedpdegvagaptgsspqplqplsgeddayctfpsrddlllfspsllggpsppstapggsgageermppslqervprdwdpqplgpptpgvpdlvdfqpppelvlreageevpdagpregvsfpwsrppgqgefralnarlplntdaylslqelqgqdpthlv |
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