|
|
| Record Information |
| Record ID |
141 |
| Pubmed ID |
34526360 |
| SNP |
|
| Gene ID |
29851 |
| Protein ID |
Q9Y6W8 |
| Vaccine Adverse Events |
transient lymphopenia, injection site reaction, fatigue, flu-like symptoms temporally related to vaccination, and arthralgia and decreased lymphocyte count, asymptomatic transient elevations in autoimmune serologies |
| Vaccine |
IGFBP-6 N-terminus plasmid-based vaccine |
| Gene Name |
ICOS |
| Official Symbol |
inducible T cell costimulator [Homo sapiens (human)] |
| Aliases |
AILIM, CD278, CVID1 |
| Other Designations |
inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; inducible T-cell co-stimulator; inducible costimulator |
| Chromosome |
2 |
| Location |
2q33.2 |
| Annotation |
Chromosome 2 NC_000002.12 (203936763..203961577) |
| MIM |
604558 |
| DNA Sequence |
>NC_000002.12:203936763-203961577 Homo sapiens chromosome 2, GRCh38.p14 Primary Assembly
ACTGTCAGCTTTGAACACTGAACGCGAGGACTGTTAACTGTTTCTGGCAAACATGAAGTCAGGCCTCTGG
TATTTCTTTCTCTTCTGCTTGCGCATTAAAGTTTTAACAGGTAAGTGGTGTATTGAATATTTCTTATTAA
GTTATAATTCAAGTAAACATTAAGAAAAAGCAAAGGTAGAAAAATTACGCACCCAAAAGACAGTGGTTTT
GGTTTTTGAAAGTAGGAATAGTTTCAGGATATGGCCAAGGGCACCATGTCACTCATGTCACTGTGGATGG
CATTGAGTTTGCATTGCTGCCTTTGATACTGTGTCTTGAGATGAAAAACATGTTTCATCAGACCATTAAA
TTTTTAAATTACCTGCTTGGAGTTACCTGTCAGTGGATAAACTAGCAGAGTGGCTTACTGTTCTTAGAGA
AAGATGAAAGGCAAAATGACTTGTGTCAACAGAATGAAAATTAAATAGCTCTGGCATTTGGACTGGGAAT
TCTTTCTGTGGTAGAAAATAAAATGGGAAGTCTTTGAAAAGAAGGATTTTGATTTTAATCTTACCTGGAT
GATCTGTTATCTGAAATGTCCAGGGCACCATAGAGTTTTTATTGACACTAAGTATCAGAGTTCACCCTAA
AAAGCCAAGGAGGAAAGGATAATGTAAAAATACTTCCTAGCCCCTGTAGACCTTACAAAAAAGATCATTC
TGGAGTCCCTGATTCCTTCTCTTGAATGGCATATAGCAGACTCTATATGGACAATTTAAATAATGCTACA
TACAATGTAAGTTAATACACGTGTTTCTGCTGCTTTTTACTGTATATAATTTGTACTACTTTTGTTTTCT
CTTTCACACTGAGCCCTATTCTTGAGGTTGAAAAAAGGAAAGTTAAGTAATATTAAATAACTTAAATAAT
CAAATAAACTAAAAGTGAAGGCAGAACTTTTAGTAGGTATGATCCTATCTAGGGATACATTTTTTCAGTG
GCAAAAAAATAGACCTTACTGTTCTTACAAAAAATGAAAAAAAAATGAAATCAAATTGATCAAATGTTTC
ATCTTGTGCTGGCTCAAAGTGAGTTAAGTGCAGTTAAGAGGATTGAGGAATGTAGAATGAGCACAAGGAC
AGTTTTGGGCTACTTGCTGGTTTATGCCTTTTCTAGAATCTCATGAAGTCCTTTAGCGGCATGAATGACA
TGAGCAGCTTTGGAATTTATATTCATTCTTCATTCATCCATTTACTCATGTAGCATTGAGCACCTGCCTG
GTAGCAGGTACTGTGCCAGATGGTGTATGTACAAGGATGAGCAAAACCAGGTCAACCCCTGTTCTTTGGA
AGGTAACTGCATGGTAGAGAGAGATATATTAATCAAATAATCCCATTGATTAATGATAATTACAGGCAAA
ACTCAATTATATGAGGGAATGTAACAAGGAGCTTGACTAGACTGGGTGGGTGTGGAGGTGTAGCTGAGGA
GCAGGGTTCATTGAAGTCTTTCCTGTGCAAGTGGCACTTGAGCGGAGATTTCAAGGACAAGGTAGCAATC
AATGGGGAGAACGGTATGAAGGTAGGGAAGAACGTTCCATACCATGGAAGGAACAAGTGCAAAGAGCCTG
TGGCAGGAAGGAATGAGGTAAGGTTAGGGAACTAGAAGAAAGCAGACAGATGTGCCTGAGCACAAAGAGG
GAAGAGGCTGAGCTTGGTCCAAGATGACCAACTGGTCCAAGTTGGTCCAAGGTGAGGCTGGAAAGGAAAG
TAGAGGCCAGACCATTCAGACCATATAGTCTATGTTCCAGATTTTGGATATTCTTCCAAGAACGTTGGTA
CCATTCGTGGAAGGGTTTGTTTGTATTGATAAAAATCATTCAACTAGGCCAAACCAATTTGGGCAGTTCT
GGTTGTGGTATTATGCTCAGGAGAATTAAAGTAGCATCGGTGTCAATTCTGTGGAAGGTGAGATCCAGCC
TTAGGTAGGATTGTTTTAAGTTTCCAGATTAAGCTGACGAATAATTTGTATTCTGGAACAATATTCATCG
TAGATTCTAAATGAATACAACCAATGTTCACTCTCATTATAAAGAAAGCCATGAGATGTGGCATGCTGTT
TGGCATGTGGCAAACCTGAGGCACGAGTGGCTAAATGGTAACAATAAATCTGCTAGCAATGATCCTATTT
AAAATATCTCCACAATGCATGTATCCAGAAACTGCCATGTAAAAGCTCTAAAGAAAAAGAGCCAAACTCA
AGTAAACTAAGTACTTGCTTGTCCTCTGTTGTATTTTCAATCCTCCCAATTTACATAGGCTTTCTCATGC
CATGAAGATGTAGGCATTCTTACCTTTAGTCAGTGTTTGAAGAATTTCCAACCAGGAAAGGTTAAGTGAT
TTGTTACACAGTAGTTGGTGGCAGAACCAAAGTTAGAACTCTAATGTGACTCCAACATCTACATTCTTTC
TAAACTGTGTTGAAGTAGTGGAGGTGTAACATAAATCTAAAGGAACGTAAATCTCAATGATTCTGATCAC
CTTTGTTATTTGGTTGTGAATTAAGAAGGATGGGAATCTTGCTGATTTCTAGTCTTTGATGGATCTCAAT
GTAGAATTTAACAAAGTCTTGTTTTTTTTTAATGAACTTGGAGCAATAGGACACTTTTAATTATAAAAAT
ATCTACGAAAAATGTGAATGTCTAACTACATTTTGAAGACCCTCTTTGTAGACCTTATAGGCAACAGGGA
CCATATGAGTGATGGGACAAATTCTGGTTTTAGAAAGACTACTTTAAAAGCAGTGTGGATAATACACCAG
ATTGGGAAGGGCTGATGGCAGAGGGTGTCTAATAAACGTGCATGTATTATGATGTGTTCTGTGAGGAAGC
TGGGAGGATAGCCCTCAAGGCCACTTTGAGCCTTCCTTTGTCACTGAGGCATTCCATTAGTGACTCCTGA
ATTCCACTTGGGAAAAGAGCCCCTCAGTGTCTCCAGCGTCTGAGAGAAGTCTGTGAAGATGACTGACCTT
GGAGCCCCTCTTAGCCTCTCCACGACTGAGTAAATGTCATCTCCTGACAGCACCCCCTTCCAGAGTGTTC
TTGTTAGATTTAACAAAAATCCCAGTTGTCAATTTTTTCTTTTGATAGATGAATTCAGGCCATTCCCAGT
CAGCATAAGCCTCTACTTGATTTTATTTCTATGTTTATTTACTACTTATTTTTCTTTGTTGTATCCTCTT
TTTCTCTTTTATTTTTGTTGGTGTGATGAAATTTCTTTTGACTCTCCTCTTTGCCTCCGGTTAATTTGGA
AGGTCGACTACAGTTCTTAATTTACTAAGTAATTGACATGTTCAAAGAATCTTAATTGAATGTCTACTTG
TTTATCATTGTATGAAAATAATGAAAATGCCTTTGTCTGATGTGCCTAGTCCCCATCCCCTGCACTGATA
TGAGAACTTAAGAATGTTCTTCCTTTCCCACTCTCACACTTCCCCCAGACAGTGCACCCTGCTCCATACG
TGGGTTTTGTGGAAATAATTTAAAACTTACAGTTGCAGATCATTGCTAGGTTTCCTCTTACAGTATTTCT
CTTCTGTTTCAAGAATCCTTTCTTAACACTTACATCACATACGTTCAATGACAACATCATTCTGGACATC
TGCTCCTGTCTTGTGATCTCTGTTCTAATCTAATGATCAGAAGACTTCTCTTATTTTCGTTAAATACCCC
CAACTCTCTGAATTCCAGTACAGGTAAGGGTGTCTTCCTTTTACCTTGATGAGTGACTGATATCTTTCCT
GGGAATAGGAGTCCTGGATGGCAGCCTTTCTTCTTAGTGGTTGCAGATATTCCTCCACTGTCTGCTGGCT
TCTAGGGTTGTGGGTGAAGAGTTTGATGGTAGTCTAACTCTCATTCCTTTGTAAAAAAAAAAAAAACTCT
AGAATTTCATAATCTTGAAAGCTATTTACTTCAGTATTGGAATTCAGGAATTCCTCCAGGATATGTGTAA
CTCTCTCCCTCTGTTTCTCTTTCTGTGTGTTTCTATTAATTTTTTTTTTGAGGCGGAGTCTCACTCTGTC
GCCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTTACTGCAACCTCCACCTCCCGGGTTGAAGCGATTCT
CCTGCCTCAGCCTCCCAAGTAGGTGAGACTACAGGCACCCGCCACCACGCCTGGCTAATTTTTTTGTATT
TTTCGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCAATTTCCTGACCTCGTGATCCGCCCAC
CTCCGCCTCCGCCTCCGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCCGCTGTTCTAT
TAATTTATTATTATTTTTTTTAAGACTGGGTGAAAGTTTTCAATCTCTAGACTCAAGCTTTATTCTTCAT
TTCAGTCATTTTTTTCCTAGTATTTGTTTAATCATACCTTATGCTGTTTTTCCCCACTCTTTCTAGAAAT
GTCTCTTATTCTTATGTAAGATCTTGAGTCCCTTATTTTTTCATCATTTGTGAACAAAATGGCTTTCACA
ACTTGCTGTTGCTTGTTAACCACAACTCCTTCAGATGAAATGGATATTTCAGTTTTAAGTTACTAGTAGC
ATATTCCCATTTCTTGGTAGAAACAAAATGCAGGCATGTAGGGGGGACTGAAATTCTTATATTTACTCAC
TGTAAGATTCATAGCATTATTTGGCTTAAAAAAATTCATCCCAGTATTCACAGTTGTAAACAGCAAAATC
TACAACATATACTGCTTCCCTACTCTAAGAATATTGAGTTTTATATGCAAAATGACTTACTGGGCTTTGC
AAATTTTTAAAAATGAGTTTTAAAATCATTTGTAGCTTGCAATAACTGAAGAAAAGATCACAATTTCTCT
GTAAATGGCATCTCAGTACTACTGCTGTTCTAATAAACTAGGTCTGTCAAATGGCACTTTTTGGTCATTC
AAAGTGAAAAAAACATGGCATTTGAAACCTTATAAAAATTCACAATTATATTTTGGAAAGTGGAACTTAA
GTATGTAGGGGATATGTCACACAAATTGAAAGTGTTAGTCAAGAAATGATTTTTTTTTTCAATAGTTTGG
CCTGTAAGGTTGACCAAAACAGGTAAAGATTTGCAAGTTTAGAGAGTCAGAAACTGGGGATATGAACTTC
CTTCTGGTTCATGTATAACATAATGATGCTTGTATCTACTTTGCTTGAGGAAAAAAAAGAAACACGTTGT
CCCCAAATAGGGTGATAGACCAGGAGTTTCCATCCAGTTGACCACGAGTGTTGTTAGGATCTGTTTATTT
GAGTCATGTTGACACAGACACAGCACTTTCAATAAGCAATTAATGATCATTTAAAGGTAACTTTTTTGAA
TTTGATAAATAGATTTTTTTTACAGCCTGTATTTGTGTTCTTCTAGGACTTTGCAACAAAGAATCTGTAC
ATGCAAAAACAACAATAACAACAACAAGCTGTCTACTGCACTCACAGTTAAAGTTCTGTTTACTTTGCAC
TATCTAGGACTAATGCAAAAATCTCATAGATGTGCCTATTTGCACTTATTTAATTATGATGAAATTTACT
TCTATATGTGAATCCATTTCTGTACATTTCTACAGGCAGATAAGTGATGGGAAAATCATTAAGAATTTAG
ACTTCATCAGAGAAGAACCCAGGTACAATGACAGCCCAGCTTAATACATGATGGCTGATGAATGAAAATG
TCTAGGGAAATGAGTGTGTTATGTACAATGTAATTTCATATCTAAGTCACTTTAAAATAATTTTTTGATA
TATAATAACCCTTTCAATCACAGAACACATATGTGGCACCAATGTGAATACTACTTTAAGTATTAAGGTG
ATAATATATCCAATATACCTAGAAGGAAAATAAATACCTGAAATTCATTTTCATATCTAGCTTAATGTTA
AAAGCTTCTTTTTGTTTTTTTATTTCGTAGCAAATCTCTTTAGCTCTGATGCTTTAGTTTCTGTACAATG
AGAGGATTGGACTAGATTATTAGGTGAAGAGATTAAGTAAGTGTGTGTACCCTGGTGTCAAATTATCTTA
TTCTTTTTTCTTTGTTTTTGTTGGACTGGGTTAATTCGAAGACCTTGTCTTCAAGCTCTGAATTTCTTTC
TTCTAGTTGTTCAATTCTATTGCTGAGACTTTCCAGAGCATTTCACCTTTCTAAAATTGTGTCCAAAGTT
TCCTGAAATTTTTATTGTTTTTTCTTTAAGCTATCTATTTCCTTGAATATTTCTGCCTTCACTTCTTGTA
TCATTTTTTGCATTTCCTTGCATTGGGCTTCACCTTTCTCTGGTCCCTCCCCGATTAGCTTAATAACTAA
CCTCCTGAATTCTTTTTCAGGTAGATGAAGAATTTCTTCTTGGTTTGGATCCATTGCTGGTGAACTAGTG
TGATTTTTTGGGGGTGTTGAAGAGCCTTGTTTTGTCATATTACCAGAGTTGGTTTTCTGGTTCCTTCTCA
TTTGGGTAGGTGCTGTCAGAGGGGAGGTCTAGGGCTGAAGGCTGTTCTTCAGATTTTTTTTTTGTCCCAT
GGAGTGTTCCCTTGATATCATACTTTCCCCTTTTCCTATGTATGTGGCTTCCAGTGAGCCAAACTGCAGT
GATTGTTGTCTCTCTTCTGGGTCTAGCCACCCAGCAAATCTACCCGGCTCTGGGCTGGTATTGGGGGTTG
TCTGCACAGATTCCTGTGATGTGAACCATCTATGGGTCTCTCAGCCATGGATACCAGTGCTGTTCTGGTG
GAGGTGGCGAAGGGTGCAATGGACTCCATGAGGGCCTTTAGCTTTGGTGGTTTAATGCTCTATTTTTGTG
CTGGTTGGCCTCCTGCCAGGAGGTGGCGCTTTCCAGAAAGCATCAGCTGTAATAGTATAGAGAGGGTCTG
GTGGTGGGTGGGGCCCTAGAACTCCCAGGATTATATGCCCTTTGTGTTCTGCTAACCAGGGTGGGTAGGG
AAGGGCAGGGCTAGGCATGTCTGAGCTCAGACTCTCCTTGGGCAGGTCTTGCTGTGGCTGCTGTGGGGGA
TGTGGGTGAGATTCCCAGGTCACTGGAGTTGTGTACCTAGGAGGATTATGGCTGCCTCTGCTGAGTCATG
CAGGTTGTCAGGGAAGTGGGGGAAAACCGGCAGTCACAGGTCTCATCCAGATCCCATGCAAACGGAAGGG
CTGGTCTCACTCTAATCATGCCTCCTCTAACCGCCCCAAGTCTGTTTCCAGGCAAAGGGCAAGACTGGCT
TGAAAACTTGCCTGAGGCTTTCTGCCTCCCAGCTGTGAAAGAAAAGGGCTTTAGTTTTTCCCCTGCATGT
GAAATCTGCATGCTGGATTCACGGCCTCCCCCCAGTTCAGGCCAGGAGACTTCTTGCCCTGTTCAAATAG
TTACAAAGTTCAGCTAGAGAATTCCTTCTCCCTGTGGAGTTTTATACCCTGCTCCTCTGGCCACCCTCCA
GATGGATCCCTGTGGTGCCTGGCAAGAATGGGCTGCTTGGGGACCCATTGAGCTCCCAGAGCCTTTCTGC
AGCTTCCTCTACCCCTGTATTTTGCTCCGTTTGGCTCTCTAACTTGACTCACCTCCAGATAAAGTCGGAA
ACTTCTCCACAAACAGACGCTCAGCTTCTCCGGTCAGAGTGTGTGTTTGGGAGAGGAGGGTCTCCCTTTC
CCGTGAGTCTTTTCTTTTTGACTGGGAAATAAGTATCTCCCAATCTTCAGTAAATAGGATCTTTGCTCTC
CTTTTCCCACTCCTCTTCTTGGCCCATTACAAAGATATTTACCAAACATGCTTAGCCTTTATATTCTTCT
GTTAATATTAATTCTTTTATTTAATATGATTGAGCTTCCACTATGTTCAAGGTCCTGGGATTTTTTAGGC
AACTGTAATGCAGTCCTTATCTTTGTGGAGCTCATGGTTAAATGAGGAAGACAGACAAAAATAATTATGA
TCCAAGATGCTATGTGCTAAAATATACTGGCCTAAACAAAGTATTATTGGGAGCATAGAAATAAGAGTCT
TTGTCTGGTGGTCTTGGAAATAAATATCTCAAGAGAGAAGTTGACATTTAAAATGGTTCTTGAAGAGTGA
ATGAGAATTTCTTCTCAGATTAAGGGGTAATCAAATATTTTAGTTCATGGTAACAGAAATAATGAAATGT
GAAGCATATTCTAGTAGTAAAGAACAGAAGTGTGAAAGAAATGGCCAAAAAGTTCAGTGTGGCTTCAATA
GATGGCCTATGAGATTGTGAAAGCATTTTGTGTCAAGCCAGATATATATATTTTAAAACACCTTATAAGC
AATAGAACACTAATAGAGACTTTTAAACTGGGGAGTGAAATGCTTTTCTGAAACATAATTTTGGGAGCAG
CATGGAGGAGGGATGGGGAGGAGAGAGATCAGTATTGAGAAGGCCAGTCAAGAGGATGCTTCCACAGATA
AGGGAAGACATGAAAAAGGTGTGGATTGGCAATGGGAATGGAGAAAAAGAATTGAATTTAAGAGATATTC
ATGAGCTGGAGTCAACTGGACTTGGTGACCAATTGGATGATGAAAATCAGAGAGAGGAAGAAATGAGGAA
GACTCTGAGGTTCCTAGGGTCAGACTAGTGACTCCCTGAAAAGACAGGGTTTGGATTTGGTGAATGAATA
CAGTCACGTGCCACTTGACGATGGGAATACATTCTGAGAAATGTGTCCTTAGTGATTTTGTTGTGTGAAC
ATCATCGAGCGTACTGACGCAATGATGTCTACTAGATGGCAGAGCCTACTGCACTACCTAGGCTATGTGG
AGTAGCCTATTGCTTCTAGGCTACAAACCTGTACAGCATGTTACTGTACTGAATACTGCAGGCCATGGTA
GCACAATGGTAAATATTTGTGTAACTAAACACATAAAAGGGACATTAAAAATTTCTGTATTATAATCTTA
TGGGACCGCCACCATATATACAGTCCATCGTTGACCAACATGTCATTTATGCAGCGCATGACTGTACTGA
GCTCAGTTTGGAAAGGCTATACATGATGTGTTAGGGTAAAACCAGATAGTGATGTTGAAAGGAATTTGGA
AACAAGGAACTAGAAGTTTGGGCTGGAGAGAAAATGTGGGCTCCTGGGGGTAGACATGAGAGCTGGAGCC
ATAGGTGCAAATGAGTTCAGGCAGTGAACACCCTGTCCATGTGCCCAAGGAGTTTTGCACAGTAGCTGAG
CAATGGCAAGCAATGTGGGTATTCAGAGGTGTGGATAAAATCCTCTCTCCCTCCCACTCTGTGGAAGAGA
GTTGGGTTCATTTAATCTCATATGATTTCCCTAGTACAATAGTTTCAAATCAAAGGCAATGAAGTAACTA
ACAAAATAACTTGTTTGTAAATTAATTGCTTTGTGAATATTGATACAAAGTTTTATAATACCACTGGGAT
TTTTTCATTTTTCATGAAGAAATCAGTTTTAACTAGGAGAAAATCAATCTTTCATTTTTCTTATTATACA
CACTTAGAGAACCAAAGGGTTGTTTTGTACCCCCTATGGAGTTCCTTGGAGAGTAAAACAATGCACACAT
TGTGTGTGTGTTCATGAGCACTCTTTTGGCTTTTTCTCCTCACTTTTCTTCTTCCCATTTTTTTTTTTTT
GCTTTCTTTTTTTTTTCTCCAAATGTTAGGCATTTAGGTTAGATTGGGTTTATCTTGTCTATCCTCCCTC
CCTTCCTTGCCTCAATTACTTCTTTAGATTATGGGTGCCTTTGAATAGCAATGTAAGTTTAGAAATGATG
CATATATAAAAATCTACTAACCAGGGATCTAAAGGTTTTAGCTGGTAGACTCATAAGACATGACATTGCT
TTTATGAAAGGTGAGAAAAGTGGTAGGAAGTACTTTTTTTTTTAATGCCAGAATTTCTTAGTAAAACATC
AAATATAACTAAAACCTAATATAAACATTGCAATTTTTAGACTTTTGCCTCTTGTGTCACATTCATGTGC
TGTGCTAAGCTAACACTTATCATTGTTTGATTACAGAAAATGTGTTTAATAAGCACTATCAATGATTACA
AACTCAGGACATCTTATCTTTCCATCACTCTGAGACCTTTGTGGAGGTTTGTGGTTAGAAGTCTGAGTTA
AAGAAAATAAAATTACATTTCTGATATCTTGCACGCTCTGCACTGAGTGGGTTCTTTAAATGTTTCCTCC
AGAGGATTTTCAACCAGGAACAATACAACTGCTTGCAAAGAGTCCCAGCAGGATGGGTCTGGGCATGAGC
ATCTTATACTGGTGAAATGAAGTAGTCCAGATATTAAAAGCATCAACTTGCAAATGAACTCATCTGCACT
ATAGTGCAATTCTCAGGTGAATGACCTTTTCTTCAGAAATTTTCTTAATAGTCCCCCAAAAGAAGAAGAA
AATGTTCTTGTGCTTTATAAATTTTGAAAACCTAAAGAGATCACTTAATATAAAGATTTTTATTTTACTC
TTGAAAACATTAGTCTATTGATATCAACAGTAATATTATAAAAATTATTATTATTATTATTTTTTGAGAC
GGAGTCTTGCTCTGTTGCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCTGACTCCCT
GGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACACACCACCACGCCCAGC
TAATTTTTATATTATTAGTAGAGACGGAGTTTCACCATGTTGGCCAGGATGGTCTCAATCTCTTGACCTC
GTGATCCTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGGCGAGTCACTGCGCCCGGCCTATAAAA
ATTATTGTTAGCAGCAGTTAACAGTCTTGAGCCTCTACTGGGAAGAATATGCCCTGTTAGACACAGTATT
CTATGTGATGAAGAAAATATAGTACCTGTTCTCCAGACTGATTATAATCTAGGGTTTCCAATAAAAAGTA
AACAGATATGGTAGCAAAACAAAACCTCATGTTTAATATTCAGATTTTAAGACTCATCACCAGGATCCAA
GACCACATATTCCTTTTTGTGATTTTAGTAACATATTAAGTGCTAAAAGATATAAGATGATGTTTATATC
ACAAACCACTAACATGCTGTGTTTATAAAACATCTTGGTATATTAGAACAACCATTGGTCCAGGGGTTCT
TGTCCTGGTCATATATTGGGCAAATGTAATGGCTGCGCTTTGGGACATCCAAGTGAGCAACCAGGTTTGT
TGCTCACTTGGATGGAACAAAGTTGTCCTGCCCTCCACAGACATATAAGAGCCAAGAGAATTATCAACTG
TCTAAATAAGTATTTATGAACCCAGTGGATATTTGAAGGTAAAGAAAGTTTTTCTTTAAAGCTCAGACAG
ATAATTTCCATTAGAACATGACATCTCAGTTGGGGTAGTGTCTTGTATGCATGATTGTGTATCTTCATAC
ACTTGTTTCCAGAAGAAAAGCAATAATATGGCATAGCTAACTCTGGGATCATGCCCCAGCTATGAGCTAT
GTAATCCTGGGCAAGATAGTCACCTTTTCTGGCTCTAGTTTAATTTGATAAATGCAAATGGAAAATGCAA
AATGAAAGGTTTAACTTGTCATTTCTAGAAGCCCTTTTGGCTCTTATATTATAAATCCTGTGCTTCATCT
CCTCAGATTTAAAATGTCACCGTCTATATATTCATTTGTTCGCCCATCCAACCATGCTTTCATCCATCCA
ATAAATACTGATTGCAGCTTACAACACACCAGGTATTATTGTAGATACTTGGGATGGATTTGTGAATAAG
ACCAACAAGGTCCCTGGTTTTAAAGCTTAGAGTGGAGTAGCCAGACAATAAAGAAGAAAACAATCAGATA
AACCAGATAATTTCAGACAGTGATAAATGCTTTATGTCAGTTAATGTACTAGATAATGACCTGGATATAT
TCTTTAGATTGGGTGGCCAGTGGTCACTGAAGAAGTGTCATTACTCTTGAACGATGACAAAGAAGCAGCC
ATGTGAAAATCAGAGAGAATGTTCTAGGTGGAGAAATGAGAAATTAAAAGCCCTGGGAACCTGCTTTGTG
TGTTTGAGGAACAGAAAGAAGGGCAGTGTGACTGTGGTGTAGTGTGTGACTGGTATAAAATGGGGAGAGG
TAGGAGAGGTCATGCAAGTCATGGGAAACCAGGGTAAGAACTTAGATTTTACTGTAAGTGGAATGAGAAG
CACCTGGAGGTTTTATAAGCAGAACAATGACTCTATTGGATTATGCATGTAAGAAGGTCATTCTGGTTTC
TCTGTGGAGAATGGATTGTAAATGGGCAGGAGTAAAAGCAGAAGCTCTTGTAGTCCCAGAGAGAGATGAC
AATGGTTTGGACCAGTTGAAGCTGAGATGGAGGAGAAGTGGATAGATTCTGTTGGACATAAAACAGAGGT
GCTGGAAATTAGGCGTTCTTCCTGCTCACAGATTTTTAGCACTGGTCCTGTAACACTCAGTTGTTAGTGA
CCACTGTCTAGCTTCCTGTGGTTGCCTGCTTCTATTATACTTCTGTTGATTGTTGCTAGTGACACTTTGA
CTGTGGATTGAACCAAAAATCTTTCATGCACCCAGGAAGCTGTGTGACCTCGGGCAAATAATTTAATCTG
TCTGGGCCTTCAGTTGTCTGTATGTACACAAAAGAGGTCACCAGATCTGACTGTGTATGATGCTGAGAAG
AGGTTGAATCATGTTACAGGAAACAAAAAGTGTAAAGCTGAGGGTATTTATAGGATGCCTGAAACATGAA
GTGTTGATGAAATTTATTAGCAATGGAAATGGTATGTTAGGAAGCATGAGGAGCATATCAAAGATAGTAT
GAGAGAGGATGTTTTGGAGAAGATTTTATATTAAAGGTGGTATGGGAAGAAAAGGCAAACATGAGAAAAA
GGAAGAAAGAACAAGAAGAGAGAGATTGGTAAGGGGAACACTGACAATTTTTAACTACTGGTATGGCAAC
AGAATTGACCAAATAGATTTGACACCTTACCAATCAGAGCAGACACTATCTATAAAAGTGGTGCTATCTA
TCATACCAGCATTCCAGGCTGAGTATTAGACTTGGAGATAAGAACATCCAAGAAGGATGGAGAAAAGATC
CTAGATGCTTTTGCAGTTATAAGAAACTAACGTATTCAGATCTTCCTTAAATTGTCTATCCATTAAATGC
TTTAGTCATGGTTATAAGGGGCAGTCTCCTTTAATACTATTTTCAAATGTTACCAAAGGCTAAGAAGAAT
TTGTAATTTGTCATTTGAGCATTGTCTTAGTCCATTTTCTGTTGCTATCACTGAATACCGGAGACTGGGT
AATTTATAAAGAAAAGAAATGTATTTCTTACAGTTCTGGAGGCTGGGGCCTAAGTCTAGGGGTCTAGGGG
CCTAGGTCTAGGCTGAGGCCTAGGGGCGAAATCTGGTGAGGGCCTTCTTTCTGGTGGGGACACTCATCAG
AGGCCCAAGGCAGTACAGAGGATTACATGATGAGGAGGTTCTTGAGAGACAGCCAATCTGGCTGTTTATA
ACATACTAACTCTCATGATAATTAACCCACTCCTGTGATAACCTATTAATCTGTTAACCCATTAACCCAT
GAATTGGATTAAGCTATTCATGGGGGTTCTGCCAATCATCTCTTAAAGGCCCCACCTCCCAATTCTATTA
CACTGGGGATTAATTTTCAATATGAGTGTCAGTCAGAGGGGGACAAACATTCAAGCTATAGCAAGCATAT
CTGTTCTATATCTGCCAAAATAGTTATGAAATAATTAATTAAATGCTATAGTTAAAAACATTCGAACTGC
AGACTTAGAGCTGTCAAGCGGTTTTCCAGATGGAAAGTTTAAACACTGGATATGTGGAAACCTAAGTCAG
CCTTCTGATCACTACATTTCATAATAAATAGGCGATCCAGGTAGTTTTTAAGTTAAAGATAAAAAAATGA
GTAATTAAGAGCGTCCAGGCCAGGTGCGGTGGCTCACGCTTATAATCCCAGCACTTTGGGAGGCCAAGGT
GGGCGGATCGTGAGGTAAAGAGATGGAGACCATCCTGGCCAACACGGTGAAACCCTGTCTCTACTAAAAA
TACAAAAATTAGCTGAGCATGGTGGCATGTGACTGTAGTCCCAGCTACTTGGGAAGCTGAGGCAGCAGAA
TCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCACCACTGCACTCTAGCCTGCTGGTGA
CAGAACAAGACTCCATCTCAAAAAAAAAAAAAAGAGTGTCCAATAGAAATGACACTCTGAAATCTTCAGC
TGATGTCAGTGGCACACACTCTCAACATGCCATTCAAGAAAAATTGAGGCACGGCATTCCTGGTCCTACC
TAAATACTTTTGTGGGCAAGAAAGACAGTCTCCTTTATTTTAATTTATTCTGACTTTCTGGAATAGCCCA
TTATGATATTGAGACAGAAAGTGGTTAACAGGAACATTGTTTTCCCTTTGGAAGACTTACCCAACAGCAA
AGAATTAGCTCTCTCAGTTGTTTGCAGTCTTATCTGGATATATTCTGATGCTGAATCCAGAGAAAGCAGG
TGTTAGAAATAACATTAAGATGTTTTTGTTTCACTTCTTCATTTCACGGATGAGGAGGCTGAATTCCACA
GGGGTACCCTAGCCACAGAGCCTTGCTAGTGGCAGAGCCAGAATTTGCCTCTGGTTTCCTTGGGATCCAC
TGCAATGCACTTCCACCACACTGCACCGCCAACCATTCATGTCCTCTTGTGTTTGCCACAGTGCGGGCAC
AATGGGGGAAAAATCTGCTGAGAAAATCATCTTCGGAAGTAGAAGACAATGCGTCTATGTCTGTGTATAC
ATGGTGACCACAGACGCTTTGGCTCCAAGATCATTGTGGTTTACTTGCTGCCATTCTAAAGTCTCTGGGA
AATTTTTTGTGAACATTTCTAAAGGAACTGAGAACCCGTCCACTGATTTTATCTTCTGCAGCAGACGGTA
GAGACATACGCATCAAAGCAACAGTGGGGCAACATATTTTACTGTCAGACAAATAAAGCCCCAAGCAAAA
TACCCTACGTTTTAATCTAATGTAGACTGCACCTGTTCTCATGCCAACAGTTTTTTTTTCTTTGCCTCTG
GATAATATTGTTCCTTCCAGTTTTTAAAACGAAGCAAGTATTATTTTCCTTCTGTATGCTTTTAAACATA
CTTGTTATTATAAAACAAAACATACATATAGAAAAGTGAAAAAAATGTATAATTTAATGAATAATGCTAA
AGCATACTATCTTACCCTCATAATCACCACAGGTCAAGAAATACAAGACTGTCAGCACCCCTATTTCCTT
CTGATTCCAACTCTTTCTCCCTCTTTAGACAAAACCATTAGGCTGAATTTTGTGATACTAATTCAGATTA
TATTAACTATTTCTATTTTTTAGTAATTATGGAAGAAATCAAAACATGTATACTTCACTTAGAAAAGTTT
CAAATTACATATACCTTCACTATCTTTCTAGACAATGTGCTCTATATTGACAGATGTTTCTTTTAGCACA
TTGGAGGTATATGTTATAATTCCACTGTATCAGGGCTTTTATTGTTGATGTTGAAACAGTCTAATAGTTG
CTCCTTGGAAGGTAATCAGTCTCTTTTCTCTGGCTGCTTTTAGGATTTTCACTAAGATACATCTAGGTGT
GCATACTTTTAAAAAATATGCTTGTGAATTGTTGGGATTCTTGAATCTGTGGAGTGTGACTGGGTTCTAA
CTAATTTTTCCAACCTATCTGCTGGTTCACCAATTTTCTCTTTAACTCTGTCTAATATATATTAAACTTA
TCTATTGAGTTTTAAATCTCAGTGCATTTTTTTGGCCGATTCTTGTAGGTTCTTTTTCAAATTAGTTGAC
TTAAATTTTCCTGTGTACTACAGATATTATTACAAGTTTTTCTCTTATTTGCTTAAACATAATAAGCTTA
ATTACTTTATTTTGGGGACCTGATAATTCAGGTATATAAATCATGAGTTTGTTTTTGTAGTTTGTTGTTT
CTGTTGTTCCCTTGTTTTCTTGTATGTCTCATTATTTTTGTGATGTGTTTGCCATTGAATGTGAATATTA
TTTGTATGAAATTTTTTGAGGCCTAGGATGTAAACCTTTTCTTCTTGTAATAGTTTGCATTTTTACTTTC
AAAAGCTGAAGGGTAATAATAATGCAAATCTCCTTAAAGAAAATTCAAGGATTGAGGTTTTCTAACCATT
GAAGTCCAGAAGATTTTTCTGGACCATCTAATCTGAATGAGGTCTGGTTTATTTCTTTACCTGTGCTCCA
AGAATGTAACTCTTTGGGGTCCCAATTTATTGGGGAGAGGGTTTTCTGCTAGATCACTCACTCTGCAGAT
TCTGGGAGTTGAGACATAAAAACAAAAGTTTGAATTTGAAAGAACAGCAATGCTTTCCGAGTAAAAGCAG
CTTCCAAGCTTTGCCTGTCTCTCGGGGTTCTGGTTCTCTCTTCAAATTTAGCCTGGTAATTTCTCCTCCT
TTGTGTCATTCTTTAATGCTTTTAATAATATTTTTGGACATTTGTTCAACATTTTTGGTTGTTTTGGCGT
GAGAATTAGTTTGAATAATAGGGACTGCTATAACTGAAGACTAGAACACTTGTGCTTATTTTCACAATCA
AATCACCCAAATTGAAGATATATAGGGAAAATATAAATTGAAGCCCAGGGTCATTAAGAAAATAAGTAAT
TGTGTATCTTAAATAAAATTAAGGCAACTAGTGTAAGTAGAGGTGTGACAAATAGCCCCTCCTGCATAAT
GCTAATCCTGTTACAAATTTCAGAAAGCAAAATGGCAATACATAGTATTATAACTTTTAAACATTTTGAC
CAAATGTCATAATATTTACATAAAAGCAAAATGCTGAAAATAATCCCAATATCCAACGTTAGTATTTTAG
TTTTAACAAATTATGATAGATTAACATTTTGGCCAATAATATAGTCATTAAAAAGGATAATTATGATGAC
TAAAAATGAAATGTTTATGACATAAAATAACAATAGCAGAACACAAAATAACATGTTTGCTATAAATAAT
AAGTATGTTTTTGCAAGATAAAGAGCAAAAATATACAAATAGTATTTCTATTTCACTGTAGAACTAGGTA
ATTTTTTTCCTTAAAATTTTTTTACACTTACATAGTTTTCTCAAAAACAAAGACCAAGATTTCAAAACTT
AGGAAAAAACCAGCATACTAATAATTTTCCCAAACAATTTCAGCATGAAAATTTGTCATATTAAAAAGGA
AAATAAAACAAAAAGAAAGAGAAGGCAATGAGCAGTTTGAATTTATAGTCTAATAACTCAGAATCTGCAA
CCACCAGGCCAAGGTGATTTCAGTTTTTTCCTTCTGTGATTCCCATGTAGCTTGCAAAAACAACCTTGGC
TTCCTATAAGCATAAATTTATTTCAGAAAATGAAAAAGTGGGGCTGGGCATGGTGGTTCACGTCTGTAAT
CCTAGCACTTTAAGAGGCTGAGGCAGGAGGATTGCTTGAGGCCAGGAGTTCAAGACCAGCCTGGGCAACA
TAGCAAGACCTGTCTCTACAAAATTTCTTTTTCAAAGTTAGCCAGATATGGTGGTGTGTGCCTGTATTCC
CAGCTTCTTGGGAGGCTGAGGCAGGAGGGACCCTTGAGTCAAGGAAGTGGAGGCTACAACGAGCTAGGAT
CATGCCACTGCACTGTAGCCTGGGGAACAGAGTAAACCCTTTTCTCTGAAAAGAAAAGAAAAGAAAAGAA
AGAGAGAGAAAAAGTAAACAAAAATCTGGGGCTTTATCTTTATTATCAGGCCTTGATTCAGTTCTCAGTG
GATGAGGTTTGGAGAAAATACATTTCTGTCATTTGAAAATGATTAGTCTGTTCTTTTACTCTTTAGCAGG
AGGACATAATGTATGTGTGTATATATGTATGTATATGTATACAATTATTTGTATATATACACACACATAG
TCTCTATATATTGTAATATACATATACATATAATACATATATTTTAATATATAATATGTAATATACATAC
ATATATAAAATATATATACAATTATTCATTTTTAAACTACTTCGTACTTTTACAAAGTGAGCAATTTCTA
TCTTTCCTTTTATCTGCTTTACTGATGTACATCAGTGATTATTTACTCATCAGAAGTACACATGGTTCTT
GTCAGAGTAGTTTGATCAACAGGTAGACAATTCCTTCTCCCCAAGATATACCTACTAATAAATGAAGTTT
TTCCTAAACTTCAACTTTTCCCATATCTCTCTGTTTAGCTAAGTGCTACTAATCCTTTAATTCCAATTTT
AAAACTCACTTCCTCAAGGCGGCATTTTCTGATTCTATAATCAAAATTATAACCCACCTGACTCTACCAC
CTTCATTTAAATAGTACTCCATTCCTATCACAAATTATGTTGCATTACTACATATTTATTCCTTTACCAT
CTGCCTCCAATATGAAAGCTACCAAAGGACAGAGGCCATACCAGTTTGATTCATACACACTATGTAAATA
TATTATTTAATATTTAGTATATTCTATATTCACATATGACAAGCAAGTTTCTGGTTAGGATTTTTTTTTC
TCTAGGACATAGTTTTATCTTATGTTCTTCCTTGAGGGGTGGAGGGAGAATGTGAAGCTGTTTCATTTTG
GTGCAACAGAGATGACTTTATGCATTGAATAAATTGCTTTTATGTTAAAATATAATTATTAGGGCAACAT
TATAAAATGTCACTTTTGCTTTGTTTTCTTTCTTTTTATGCAGGAGAAATCAATGGTTCTGCCAATTATG
AGATGTTTATATTTCACAACGGAGGTGTACAAATTTTATGCAAATATCCTGACATTGTCCAGCAATTTAA
AATGCAGTTGCTGAAAGGGGGGCAAATACTCTGCGATCTCACTAAGACAAAAGGAAGTGGAAACACAGTG
TCCATTAAGAGTCTGAAATTCTGCCATTCTCAGTTATCCAACAACAGTGTCTCTTTTTTTCTATACAACT
TGGACCATTCTCATGCCAACTATTACTTCTGCAACCTATCAATTTTTGATCCTCCTCCTTTTAAAGTAAC
TCTTACAGGAGGATATTTGCATATTTATGGTAAGACATTGCTTTCATCTTCCAAACTTAAGAGTATATAT
ATGTTTTGACAACTTTTCTCACTAATAAAATCAATTAGACAAATAAATATCTTTTGTGTTGGAGTTCACT
TAGATGCAGTTGATGGTAATCATTTATAATGAAGATATACAGGTGATGATTTACTATTAATCATAATTAG
TATTATTCAGCAATATGCAATGTAATCCCATAGACTGCTAAGTCAGAAATAGATCATATTGCCTTTTAAA
CACATATGCTATTAAAAATCAGGAAAAACATTAAGACAAATACTTAAACTTATGGCTTAATAATGGGTAT
TATCTCTATTCACCTAAGATTTAAGGTTTGGTTTTGCACTGTGTTTGTGGAATGAAGTATGATGATTGAA
AATCATAGTTTTATAACATTACTTTTACTATTACCTCTTTTATAAAAATATAGGCAGAAAAGCCCTTTCT
ATTAACCACATTTGTAAATACATTATATGCATAATCTTTTAAGTTTTAGTTCCTGGATCCTTGCCATAAT
ACTGAGATGATGTTAGTCTAATAACTTGCCCACTTACTGGATTTCATGACTATAATAAAGAAAAGCTTCA
TTTGATTAAATAGCTCTTTTAAATTTGGTAAGAGAACTTGTGGTTCAGCAGAATTTTTCATTAACATACC
TTTTTTTCCAATCCAGAATCACAACTTTGTTGCCAGCTGAAGTTCTGGTTACCCATAGGATGTGCAGCCT
TTGTTGTAGTCTGCATTTTGGGATGCATACTTATTTGTTGGCTTACAAAAAAGGTAAGCGATTTCTATCT
TTCCTTGTATCTGCTTTACAGATGCACATCAGTGATTATTTCCTCATCAAAAGTACACATGGCTCTTGTC
AGAGTAATTTGACCAACAGGGAGACAATTCCTTCCCCCCAAGACATACCTACTAATTAAACTAATCACTT
GGAACAGAAATTTATGTATTTGTTTTATAGCCCACACATTCCAAAGAGGACTTGACTTGATGGCTTACAG
AGAGTTACATTATTATTATTATTGTTCAAACTAGATGAGGAAATTGAGGTCAAGAGAAGACTAAAGGTCA
GGAGGAAGGTTAAAACATCAAAATAGATGACTCTGATTTTTAAAAAATTATTATGCATGGGCTGCGAATT
TGAATCCAAGGTTCCTGAGAGGCAGGGCAGAGATGAAACAATTAGTTATAAGTTTTGCTTAGCTGGTAAG
TTAAAAACAGTCAGCAAGAAAGCCTTCTAAGGTGTCAATTGTAGCTGAGAAGGAAATTGACAACTTTTTT
ACATGGTAGGTTATTAGACTCCTTGCTTTTAAAGAAAACCACTGAGGAGCTATTTAGAAAGATAAACAAC
AATGACAACAACAAAAATCTCCCTGTGCTGGGGGATATTCTTTTTGGTCTCTTGCATTACAGGTTCTCAA
TCAAAGAACTGACACCACTCTGCATATTACGCGAGTATGCTAGTACTCAAGTATATCCACAGTGTGGTCA
TTGGCCAGTGTATATCTGTGGGAGAGTGGAATTTGGAAAGAGACATAAAGAAGGAAGAGAATGAGATAGC
GCCCATGGTCTAAGTCTGCTGGGAAAGAAACAATAAAGGCAAAAACGAGGAAGAAAGTTCAGTAGAAAGC
TCTTTTTATGTAAAGCCCTTTTCATATTGTTTTTCTACTTAGCCTAAAGCCAGGAACCTAAGTCACATTA
TCATGTTTTTGTCACATACCACTTCAACAAAGAATAGAAAACAGTCAAAAAACAAAGAGATGGAGAAGAA
AAGATGACCAAGCATGTTTCTGGCTTTTTCTTTCAGAAGTATTCATCCAGTGTGCACGACCCTAACGGTG
AATACATGTTCATGAGAGCAGTGAACACAGCCAAAAAATCTAGACTCACAGGTATGACTCCATTTGGGGG
TTTGGGAAGGGAAGAGGTTTCTTCACAGTAAGCCTGGAATGTTAATTTTTTTTTTTTTAATTTTAAAGGA
AAGGAAAACATCTCCAAGGCCTAATTCTAGAATTTTCTGTGAAAATCTGGATTTCTCACTTTTAACTAGA
TTTATATTTTCTGCAGTATATTGAAAACAAACAAGCAATAGGTTTGTAAGCCACTATTGAAACTAAACAC
ACAAACAGCTCATAAACCACCATAGTATCAAGGCAATTTTCCCATTGATGTTTCAAAAGTTGGGATGATT
CTAAGTGTTTTTTGTTGAAGGGTTCATTCAGTCATTCAATGAGCGTTTATTGAGCATCAGTTAAGTGTGA
GTTACTGAGTGAGGCACTCTGGGGAATTTGGACAGATATATGCTAATTTTGGACTGAGATTAGGAAGAGA
GATCTGTGCTGGTACTGCTAGAGGGAAGAAGGAGAAATTGATGAAGATATCTGGTTATTTTGAGGTAAAG
AGTGTGCAAGTTTAGAGAACTTGGATGGCTTTAGAAGTCTCAGTAACATGGAAATTTGACCTTTTCTGTT
AAGAGTCAGAAAACTGAAAGTTGCCAAGTTTGAGGAGCACCCAGAAAGTTTGAAGCTTCCATTGTGGAAA
ATTCATGTCTTATGCCCTTGAGGTTCGAATGATGTGCGATGTGTAATGAGACAGAAGCCACTGCATTTTT
CCACCCCTCAGTGGCTACAGATTATCTAAAGGGGACACACATAGCTTGCGTTGTCATGGAATTATAGCAT
GGGATGGGAGCTAAAAAGGATCCTTGAGTTCACATTTCATGTTTTAGATGACAGAAATTGATGCTCAAAG
TGTTCAGTGACTCTTTTGGTTCCCTAGACAGTTAATACCTAGCTTTGACACTTGCAAAGAGCTTATGTTT
CATTACTTTGCTGTTTAAAAAATATATGATCTCTCAATCTCTTTGCTTAATGTGTTCTGGCTGTTTGGAT
CCCCACAAGCAGAACCTGACATAAGGACTTGGGTGCAAGTAGTTTATTTGGGAGGTGATCCCAGGAAGAA
GGGGTGAGGGGGCAGGGAGAGTGAGACAGCCAACAAGGAGAAGCAAATGAAGGGCGCATTATTATCAAGG
TCTCAGCTCCAGGCCACAGAGGCCTGACTTCATTGGACCTCTGAGAAGTGTACAGATGCCTCCCAGAATC
ATTCTCTTGAAGGATGGCAACCACTGGCTCCATCCTCACTGATTTGGGGTTGCCTGCGGAGGGCATTAGC
TTTCCCTCATCTCTGAGCTGTGCCTCTACTTGGGATGAGCCTACTTGGGATGAGTCTTCAGAGAAAGTCT
GGAGGCAGAAAAGCAGTGAAATGCAGTGGGGCTGTTGTGCTAGAACAGTCAGCCCATGCAGCGCTTTCTG
CCCCAGCAGCAGCTGCAATCAGAGGTGGACAGTTTCAAAGTGATGAGTTTAGATAATGTCTGTTATAGGA
GTCGAGAGCTAAACTTCTCTGGAAATGGGGAACTGGTGCTGGGTGTTGAAGCATAAAGATGAGTTTGCAT
GGTGTGTGTGTGAGTGTGTGTGTGTGTGTGTGTGTGCACGTGTGTGTTTGTGTGTATGAAAGGCAATGGA
GAGGGGAAAGCTTCTTGTAGGGAACTGGCACATGGAGAGCATTTAGATAATTTATGCTGAATTTTTGTTA
CAGATGTGACCCTATAATATGGAACTCTGGCACCCAGGCATGAAGCACGTTGGCCAGTTTTCCTCAACTT
GAAGTGCAAGATTCTCTTATTTCCGGGACCACGGAGAGTCTGACTTAACTACATACATCTTCTGCTGGTG
TTTTGTTCAATCTGGAAGAATGACTGTATCAGTCAATGGGGATTTTAACAGACTGCCTTGGTACTGCCGA
GTCCTCTCAAAACAAACACCCTCTTGCAACCAGCTTTGGAGAAAGCCCAGCTCCTGTGTGCTCACTGGGA
GTGGAATCCCTGTCTCCACATCTGCTCCTAGCAGTGCATCAGCCAGTAAAACAAACACATTTACAAGAAA
AATGTTTTAAAGATGCCAGGGGTACTGAATCTGCAAAGCAAATGAGCAGCCAAGGACCAGCATCTGTCCG
CATTTCACTATCATACTACCTCTTCTTTCTGTAGGGATGAGAATTCCTCTTTTAATCAGTCAAGGGAGAT
GCTTCAAAGCTGGAGCTATTTTATTTCTGAGATGTTGATGTGAACTGTACATTAGTACATACTCAGTACT
CTCCTTCAATTGCTGAACCCCAGTTGACCATTTTACCAAGACTTTAGATGCTTTCTTGTGCCCTCAATTT
TCTTTTTAAAAATACTTCTACATGACTGCTTGACAGCCCAACAGCCACTCTCAATAGAGAGCTATGTCTT
ACATTCTTTCCTCTGCTGCTCAATAGTTTTATATATCTATGCATACATATATACACACATATGTATATAA
AATTCATAATGAATATATTTGCCTATATTCTCCCTACAAGAATATTTTTGCTCCAGAAAGACATGTTCTT
TTCTCAAATTCAGTTAAAATGGTTTACTTTGTTCAAGTTAGTGGTAGGAAACATTGCCCGGAATTGAAAG
CAAATTTATTTTATTATCCTATTTTCTACCATTATCTATGTTTTCATGGTGCTATTAATTACAAGTTTAG
TTCTTTTTGTAGATCATATTAAAATTGCAAACAAAATCATCTTTAATGGGCCAGCATTCTCATGGGGTAG
AGCAGAATATTCATTTAGCCTGAAAGCTGCAGTTACTATAGGTTGCTGTCAGACTATACCCATGGTGCCT
CTGGGCTTGACAGGTCAAAATGGTCCCCATCAGCCTGGAGCAGCCCTCCAGACCTGGGTGGAATTCCAGG
GTTGAGAGACTCCCCTGAGCCAGAGGCCACTAGGTATTCTTGCTCCCAGAGGCTGAAGTCACCCTGGGAA
TCACAGTGGTCTACCTGCATTCATAATTCCAGGATCTGTGAAGAGCACATATGTGTCAGGGCACAATTCC
CTCTCATAAAAACCACACAGCCTGGAAATTGGCCCTGGCCCTTCAAGATAGCCTTCTTTAGAATATGATT
TGGCTAGAAAGATTCTTAAATATGTGGAATATGATTATTCTTAGCTGGAATATTTTCTCTACTTCCTGTC
TGCATGCCCAAGGCTTCTGAAGCAGCCAATGTCGATGCAACAACATTTGTAACTTTAGGTAAACTGGGAT
TATGTTGTAGTTTAACATTTTGTAACTGTGTGCTTATAGTTTACAAGTGAGACCCGATATGTCATTATGC
ATACTTATATTATCTTAAGCATGTGTAATGCTGGATGTGTACAGTACAGTACTGAACTTGTAATTTGAAT
CTAGTATGGTGTTCTGTTTTCAGCTGACTTGGACAACCTGACTGGCTTTGCACAGGTGTTCCCTGAGTTG
TTTGCAGGTTTCTGTGTGTGGGGTGGGGTATGGGGAGGAGAACCTTCATGGTGGCCCACCTGGCCTGGTT
GTCCAAGCTGTGCCTCGACACATCCTCATCCCCAGCATGGGACACCTCAAGATGAATAATAATTCACAAA
ATTTCTGTGAAATCAAATCCAGTTTTAAGAGGAGCCACTTATCAAAGAGATTTTAACAGTAGTAAGAAGG
CAAAGAATAAACATTTGATATTCAGCAACTGAAAA
|
| Protein Name |
ICOS_HUMAN |
| Length |
199 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
19-JUL-2004 |
| Definition |
RecName: Full=Inducible T-cell costimulator; AltName: Full=Activation-inducible lymphocyte immunomediatory molecule; AltName: CD_antigen=CD278; Flags: Precursor |
| Primary Accession |
Q9Y6W8 |
| Accession Version |
Q9Y6W8.1 |
| Other SeqIDs |
sp|Q9Y6W8.1|ICOS_HUMAN,gi|50400701 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Mar 15, 2005 this sequence version replaced gi:7513087.; [FUNCTION] Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.; [SUBUNIT] Homodimer; disulfide-linked. {ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.; [INTERACTION] Q9Y6W8; O75144: ICOSLG; NbExp=8; IntAct=EBI-3922712, EBI-12923856; Q9Y6W8; P27986: PIK3R1; NbExp=5; IntAct=EBI-3922712, EBI-79464; Q9Y6W8; Q9UHD2: TBK1; NbExp=5; IntAct=EBI-3922712, EBI-356402.; [SUBCELLULAR LOCATION] [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [SUBCELLULAR LOCATION] [Isoform 2]: Secreted {ECO:0000305}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y6W8-1; Sequence=Displayed; Name=2; IsoId=Q9Y6W8-2; Sequence=VSP_010788.; [TISSUE SPECIFICITY] Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. {ECO:0000269|PubMed:11006126, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.; [INDUCTION] By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to be expressed into the later phases of T-cell activation. {ECO:0000269|PubMed:11169414}.; [PTM] N-glycosylated. {ECO:0000269|PubMed:11169414}.; [DISEASE] Immunodeficiency, common variable, 1 (CVID1) [MIM:607594]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:12577056}. Note=The disease is caused by variants affecting the gene represented in this entry.; [WEB RESOURCE] Name=ICOSbase; Note=ICOS mutation db; URL='http://structure.bmc.lu.se/idbase/ICOSbase/'. |
| Source Db |
UniProtKB: locus ICOS_HUMAN, accession Q9Y6W8;; class: standard.; extra accessions:Q8N6W8; created: Jul 19, 2004.; sequence updated: Nov 1, 1999.; annotation updated: Oct 12, 2022.; xrefs: AJ277832.1, CAC06612.1, AB023135.1, BAA82129.1, AF218312.1, AAF71301.1, AF411058.1, AAL40933.1, AF411059.1, AAL40934.1, AF488347.1, AAM00909.1, AF488346.1, AJ535718.1, CAD59742.1, BC028006.1, AAH28006.1, BC028210.1, AAH28210.1, S78540, NP_036224.1, 6X4G_A, 7JOO_C; xrefs (non-sequence databases): CCDS:CCDS2363.1, PDBsum:6X4G, PDBsum:7JOO, AlphaFoldDB:Q9Y6W8, SMR:Q9Y6W8, BioGRID:118933, IntAct:Q9Y6W8, STRING:9606.ENSP00000319476, ChEMBL:CHEMBL3712953, GuidetoPHARMACOLOGY:2939, GlyGen:Q9Y6W8, iPTMnet:Q9Y6W8, PhosphoSitePlus:Q9Y6W8, BioMuta:ICOS, DMDM:50400701, MassIVE:Q9Y6W8, PaxDb:Q9Y6W8, PeptideAtlas:Q9Y6W8, PRIDE:Q9Y6W8, ProteomicsDB:86805, ProteomicsDB:86806, ABCD:Q9Y6W8, Antibodypedia:34168, DNASU:29851, Ensembl:ENST00000316386.11, Ensembl:ENSP00000319476.6, Ensembl:ENSG00000163600.13, Ensembl:ENST00000435193.1, Ensembl:ENSP00000415951.1, GeneID:29851, KEGG:hsa:29851, MANE-Select:ENST00000316386.11, UCSC:uc002vam.4, CTD:29851, DisGeNET:29851, GeneCards:ICOS, HGNC:5351, HPA:ENSG00000163600, MalaCards:ICOS, MIM:604558, MIM:607594, neXtProt:NX_Q9Y6W8, OpenTargets:ENSG00000163600, Orphanet:1572, PharmGKB:PA29599, VEuPathDB:HostDB:ENSG00000163600, eggNOG:ENOG502S59F, GeneTree:ENSGT00390000000801, HOGENOM:CLU_1315009_0_0_1, InParanoid:Q9Y6W8, OMA:QDKEDCF, OrthoDB:702827at2759, PhylomeDB:Q9Y6W8, TreeFam:TF335679, PathwayCommons:Q9Y6W8, Reactome:R-HSA-1257604, Reactome:R-HSA-2219530, Reactome:R-HSA-388841, Reactome:R-HSA-6811558, SignaLink:Q9Y6W8, BioGRID-ORCS:29851, ChiTaRS:ICOS, GeneWiki:CD278, GenomeRNAi:29851, Pharos:Q9Y6W8, PRO:PR:Q9Y6W8, Proteomes:UP000005640, RNAct:Q9Y6W8, Bgee:ENSG00000163600, ExpressionAtlas:Q9Y6W8, Genevisible:Q9Y6W8, GO:0005576, GO:0016021, GO:0005886, GO:0098609, GO:0006955, GO:0031295, GO:0002517, Gene3D:2.60.40.10, InterPro:IPR039943, InterPro:IPR013783, InterPro:IPR013106, PANTHER:PTHR20904, Pfam:PF15910 |
| Sequence |
mksglwyfflfclrikvltgeingsanyemfifhnggvqilckypdivqqfkmqllkggqilcdltktkgsgntvsikslkfchsqlsnnsvsfflynldhshanyyfcnlsifdpppfkvtltggylhiyesqlccqlkfwlpigcaafvvvcilgcilicwltkkkysssvhdpngeymfmravntakksrltdvtl |
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