VAEAG: Vaccine Adverse Events Associate with Gene

Record Information
Record ID	140
Pubmed ID	34526360
SNP
Gene ID	6774
Protein ID	P40763
Vaccine Adverse Events	transient lymphopenia, injection site reaction, fatigue, flu-like symptoms temporally related to vaccination, and arthralgia and decreased lymphocyte count, asymptomatic transient elevations in autoimmune serologies
Vaccine	IGFBP-5 N-terminus plasmid-based vaccine
Gene Name	STAT3
Official Symbol	signal transducer and activator of transcription 3 [Homo sapiens (human)]
Aliases	ADMIO, ADMIO1, APRF, HIES
Other Designations	signal transducer and activator of transcription 3; DNA-binding protein APRF; acute-phase response factor
Chromosome	17
Location	17q21.2
Annotation	Chromosome 17 NC_000017.11 (42313324..42388442, complement)
MIM	102582
DNA Sequence	>NC_000017.11:42313324-42388442 Homo sapiens chromosome 17, GRCh38.p14 Primary Assembly GACGGTTCCTATATAACGTTTATTTCTGGAAGTTAAAGTAGATACAGCAATATACCAAAAAAAAAAAAAA AAAAAAAAGACAAAAAACCTCACAATAATATAAATTTTTACACTATGAAGTACACATTGGAATTTGAATG CAGTGGCCAGGACAGCAGCTTATAAACCACCTTATAGGTAGGTAAGCAACCCACGGGATTCCCTCGGCTG GGCTGGGGATGGGGAGGGGGCAGTGGACAGGAAGCGGGCAGGGCCTGAGGACCCTGTTCTTTAATGGGCC ACAACAGGGCTCAGCTCCTCTCAGAACTTTTGCTACAATCAGAGTTAAGACCAGATACATGCTACCTAAG GCCATGAACTTGACAATATCTGCTCCAGAGAAGCCCTGAACCCTCGCCCTAGGTCCCTATGATTTAAACC CAATGGTAAGCCCAAGTCTCACCTTTCTAAATATTCTGTTTATCAGTTAAGCTTATTATGTACTGAAGAG TGTTGCTGGAGAAGTAAGAGCTCTGCATGACACATCAACTGTCTCCAGGCAGGAGGACTGGGGCGAACCC TGTTCATCTTAGAGAAGGTCGTCTCCCCCTTAATTCAGAGACCAGCTAATTTGATTTAACAAACAGAATT CCACAGAAACTCTGATCAGCTGAGGCAAGGTGGTTTTGAGTTGCCAAATCCGGCCATGCCTCTGAGTCAG AGGCAGCCCATCCAGCACGTGCTAGGTGTTCCCATACGCACAGGAGAGGCGAGCTAGCCAGCCAAGGCGG GCAGGCGGGGAGGCCCTCTAGCTGTTCTGCCTCACCTGTGGGGCCCCAGCAGGGAGGAGTCACCAGCCTC AGAGGGAGGCCAGGTATACACCCTCATACGAGGGCAGACTCAAGTTTATCAGTAAGCCTTTGCCCTGCAT GAACTGAATGAAGACGCCATTACAAGTGCCACTGGATATCACCAAGAAACTGGCTAAGAACCATATTCCC TGAGCTCAACCAGACACGTCGCTGGGGCCCCATAGTGTGCATCATGTCCAACCTGTAACTCTCTCCCCCT CTTCTTCCATGAGGTCCTGAGACCAGGATTCCTAAAACAAACAGGATGAGGGACCTTTAGACACGCAAGG AGACATGCCTCTAGCAGGATCAGGGGGACTGGGGTCGGGAGGGTGGGGCAGGAAGGAAGCCAGAATCAGA AGTATCCCAGCCCTGATAAGGCACCCACAGAAACAACCTAGCCTCTGAAACAGCAGATCAAGTCCAGGGA GAAAGGGAGTCAAGGTTGTAAGCACCCTCTGCCCAGCCTTACTCACTAAAAGGCCAATACATTACAAAGG AAAATAAGTCTATTTATAAAAAAAAGTCTAAAATGCTTAGATTCTCCTTAAACCTTCCTATTTCAACACC AAAGGCCAGGTTGCAGCTTCAGATGTCTTAAGGGTTTGACCTGAAGCCCGTTTCAGGGATTATATAAATT ACCAGCCTGAAGGAAGCTGAATGCTTAAAGCACCAAGGAGGCTGTTAACTGAAGTTTCTTTTTTTTTTTT TTTTTTTTGAGACAGAGTCTCAGACTGTCGCCCAGGATGGAGTGCAGTGTGCAGTGGTGCAATTTTGGCT CACTGCAACCTCCGCCTCTCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAG GCGCCCACCACCACACCCAGCTAATTTTTTGTACTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGG ATGGTCTTGATCTCCTGACCTTATGATCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCA CCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAAT TGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCA AGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGC AGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAG AAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACAT CCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCAC TCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTG GAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGG CGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGG TCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTC TGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCC TGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGG AAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTC CTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTT GAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTA TGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGT CTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCT CAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAAT TTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGC CTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTG AGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGG CTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATC TCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCC CTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCA CCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGC AGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAA AAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGC TTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAAC TCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAG CCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAG TTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTG ATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCC CTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCT GAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTC TTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATAT CTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATAC CAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATC TCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTT GGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTA GAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCT CTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGG CACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAG CTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGC TCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAA GTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTT TTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGG TGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCAC AATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTA TGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGA TGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTG AACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGC TTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGG GCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAG GCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGA AAAGGATTTAATTCTCCAGCATTCAAGATAGCTGAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCTGC ACTTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTCACCAACATGGGGA AACCCTGTCTTTAATGAAATTACAAAAATAGCTGGGCGTGGTGGCACGCCTGTAATCCCAGCTACTCAGG AGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCAGAGGCTGAAGTGAGGTGAGATCGCACCACTGCA CTCCAGCCTGGGTGACAGAGTGACAGACTGTCAAAACAAAACAAAAACAAAAACAAGGCTGGGCACTGTG GCTCACACCTATAATCCCAGCACTTTGGGAGGCCCAGGCGGGAAGATCACTTGAGGTCAGGGGTTCGAGA CCAGCCTGGCCAACAGGGTGAAACCCGGTCTCTACTAAAAATCCAAAAATTAGCCAGGCATAGTGGTGCA TGTCTGTAATCCCAGCTACTCAGGAGGCTGAGGTATGAGAATCTCTTGAACCTGGGAGGCAGAGGTTTCA GTGAAGCAAGATCGCGCCACTGCACTCCAGTCTGGACGATAGAGCGAGACTCAGGCTCAAAAAAAAAAAA AAAAAAAAAAAAAAAGCTGAGAAAAATGACTTCATTGTGTGGCTTTGTACAAGATTGTAAATGTACTTTA TCTAATTTGTAAGTGGCTCCGAACCTCTCCCTCAAGCCATAAGGAAATGCTATGTGGGCTTCCAGTAGAG AAGGAAGAGAGAAGAGTCTTGGGAGGATAATCTAACCTGAGACCCTCATACCATAATACTCTTGTGATGG AAATAGAGAGGAAATGGTCACATGCTCATCGTCCTGAAGGCACCCATTTTAAAATAACACAGGGACACCC CCACACCCGTCACCACACTCACATGGAGTCCCTCAGGGCACACTCCTCTCAGCAAGGCAAGGCAAATTAC TCAAGTAATTAGTTCCTTTCTCCTGATGAGTGCCTGGCCCCTGAGGAAACGCTGACATCGCTGGGCAGGA AAGGACCTGGCCTCCCAGCCCACAGGAAGGGCGATGGTAATGGAGGATGCAGCCTCAGACTGGGAGGTGG GACCTTGAAAGCAAAATGAGTCAAAAGGACCAGCCGTGGGACCCCAACGTCCTCTGCAGAAGGAACAAAG AGCCGTGTGGCAGGGGCTGATAAACAGATCTCCCAACTGAAGCACACATGCAAAGGGAGATAGGTGGCAG ACAGGAAGTGAGTAACTCTTACAGCAGGAACAAGACTCAGGACCCCAACAAAGGAGAAAGGCAACGGTCA ATTAGCTCCAACTCCCTCTTCCAAGCCCCATTCTGCCCCATCTCAAGAAATCCCTCAGAAGGAATTCCTA GGAAAAAGTGGGAGGGAAGTTGGTAGGTTTCTGTGTGTGTGCTATTTGGACAAAAATAGTTTTTTCAACA GCAACTAGGGCAAGGCGCCAACCCTAAAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGC TCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCC AGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAG CCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTG AGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAA AAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCC CCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTAC CCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTG TGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGT GATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTAC AGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCA GGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCAC CTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTT TTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGC CTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAAC ATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAA TCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTG TAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACT GACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCT ACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCAT GTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCA GCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTC CCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTT TTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGA GCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCA CTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATC CTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTA CCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAA TGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGAT GATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTA CCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCAT TTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTG GCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAAT AAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAA TTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTG GAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCAC CCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGG TGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTG CTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTAC TGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCAT CCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTT CGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAA GCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCT TCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGC CGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCAT TCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAAT TCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATT TCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAA GGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTG GGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTG GGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCT TTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTA GCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACG AGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAG CTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCC AGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCG TCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAA TGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATA GAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGAC TGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCT TGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATC CCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTA GTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTT GATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTT TAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACT AAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATT TGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGA GCTGGGGAGGCAGAGGGGCTCTCACAGCCTTGGAAATCTCTTCACCCGCATCTCACGGGGCTCAGAATGA AAGGACATGCCATAAACCACACCTGCTGCCAACTCTAGGCGAGGAGTGTGAGTGAGTCAGCTCAGTGAGC ACTCATAGTGGAAAGAATGCCCAGCGTGGCCACACAACTCAGGCTGCAGTCGGAATATACCGGTCCCTTG TAAAACCTGACTTGCTCAAAGCTTGACTCACAATCCACAGATTCCCCATTTTTAAGACCTTGGAGGCATT CTCCAAGACTTGAAGCTGTATCTTCACATGAAACAGGGAGGTCTCAGGAATCAAAGACCAGGATTCCTGC TTTTCTAGGTATATCTTAATTTAAAAATCAAGAAAGTTGGGAAAGGAGAATGTCATTGCCACAATTTTCT GTATACTAAACACACTGGCTGCTAAGACTCTTATGCCCAAACTTTATAAAGTCAGTTCTAATTTCTTTTT TTTTTTTTTGAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAATGGCACAATCTCAGCTCACTGC AACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCGTCC GCCACCATACCCAGCTAATTTTTGTATTTTAGTAGAGACGGGGTTTCGTCATGTTGGCCAGGCTGGTCTC GAACTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGC GCCCGGCCAATCAATTTCTAAATAGAGATTTTCATATCAAGTTTGCTGAAAGCTGAATATACACACATCT TCTAAGCATTCAAGCAAGACTTTATTGCCAGATGGGATGCCAAGGATTTTTTTGGAGAAAAGTAAGCAAA AATAAACACAGTGTTAAGCAAACAGTAATCATTCCACCTTCTCTTGTAAAAATCCCAGTGGAAGTTTTTG TCCTGAGTCACCCCTGTACGTAGCCTCTCACCGATTCTGCTGCAGAACTTACCTCTAGGTCAATCTTGAG GCCTTGGTGATACACCTCGGTCTCAAAGGTGATCAGGTGCAGCTCCTCAGTCACAATCAGGGAAGCCTAC AGTAACGAGAAGGACACTCTTAGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCC AAGGCAGGAGGATTGCCTGAGCCCAGGAGTTCGAGACCAGTCTAAGCAGCACAGCAAAACTCCATCTCTG CAAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTATAGCCCCAGCTACTCGAGAGGCTGAGGT GGGAGGATGGCTTGAGCCTAGGAGATGGAGGCTGCAGCGAGCTATGATTGTGCCACTGCACTCTAGCTGG GGTGACAGAGTGAGACCCTGTCTTAAAAAAAAATTAAATTAAATAAAAAAAAAGGCTGAGCGTGATGGCT CACACCTACAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCACATGGTCAGGAGTTCGAGACCAGC CTGGCCAATAATTTGGTGAAACCCCGTTTCTACTAAGAATACAAAAATTAGCTGGGTGTGGTAGTGGGCG CCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGATGCAGT GAGCCGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAATCAATCAGTCAA TCAATAAAAAAGAGAAGGACACTTTTCCTCAGAGAGAATGGCATTCAGTACTAACAGCCACAGCCAAGGA AAGTGACATGCCAAGCCTCACCACACCAAGAAGGGTAAGCCACCAGGTGGTCACAAACAAACTGCCAGGG ACACAACTTGCTCGGCACTTACTCTCTTCAACACCAAGAACTTCCAATGCTGTGATCCTCAACCTAATCC TTTACTCAGTTTGTATTATAATATTACATAGATCCAATTGGTTATTTGTAAAATACGTAAGGCACAAAGA ATAACAAAACAATATGAACCCACCATTCAATTTAAGGAAAAGTCCATCACTCCTAAAATTCTCTGGGTGC CCTTCCCCAACCCCATCCCCTTCCCTCCTCCCTCAGAAATAACTGCTATTTTGTCTTTTGGGTTTATCAT TTCCTAGCCCTTTTTGTCTTGTTTTGTTTTGTTTTTTTACAGTTTTACCATATTTGTTTATCTAAGCAAT GCAGGTATTGTTTAGTTTGGGACATTTGTGAACCTTACACTTATGGACTCCAATGAATTCTTTTGGGATT CACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTG CGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGT TGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATT TCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTG TTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATG AATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCC GAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACT AAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAG GAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAAC GAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCT GATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATAC CAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATA CACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGC TTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTA AAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCT GTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGAT TCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTAT CTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCC TGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGA AGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTA GCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAA TCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATT TTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTT GCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGT CAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGG GTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACG GAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGAC TTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTAC CCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTC GGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGC TCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTG AATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGT TAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAG TTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAG TCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCA CCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTG ATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATG TTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTG CATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCT TTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACC ACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCAT GCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTT TCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCA CCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAG GCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCC TCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGT AGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGC CTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGT CAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGT GTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTT TCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACT TCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACG ACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATA TACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATT AACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAA AGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGA CACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAG ACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGC TAAGATAGGAGTACTTACTTGTCAATGCACACTTTAATTTTAAGCTGATAATTCAACTCAGGGAATTTGA CCAGCAACCTATTTAAAAAGAAAAAATCCAAGGAAAAAAAGTCAGTAACTCTCCCATAACCTTTTCTTGA AGAAATGTAAAATTCATAATTCTTCATTTCCAACAGGTAAATAGGCCAAGCTGTCTATAATTACAGGCTC ACATCTATAATCTCAGCACTGTGGGAGGCCAAGCTGGGAGGATCCCTTGAGCCCAGGAGTTCCATAACAG TCTGGGCAACAAAGTGAGAGCCCACATCTATAAAAAATTTAAAAATTAGCGGGGTGTGGTAGCATGTACC TGTAGTCGCAGTTACTCGGGAGGCTGAGGCAAGAGGATCACTTGTGCCCAGGAGTTCAAGGCTACAGTGA TCTATGATCATGCCACTGCACTCTAGCCTAGATGACAGAGCGAGATCCTATCTCTCTTTCTCTTTTTTTT TTTTTGAGACAGTTTCTCTCGTTACCCAGGCTGGAGTGCAATGGCGCAATCTCCGTTCACCGCAACCTCC GCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCTCAAGTAGCTGGGATTACAGGCGCGCGCCACCA CGCTCAGCTAATTTTGTATTTTTAGTAGAGACAGAGTTTCTCCATGTTGGTCAGGATGGTCTCGAACTCC CGACCTCAGGTGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGAGAGCCACCGTGCCTG GCCCCTATCTCTCTCTTTAAAAAAATTAAAATAGGGCTGGGTGCGGTGACTCACACCTGTAATCCCAGCA CTTTGGGAGGCCAAGGCAGGTGGATCACAAGGTCAGGAGTTCGAGACCAGCCTGGCCAAGATGGTGAAAC CCCGTCTCTACTAAAAATACAAAAATCAGCCGGGCATGGTGGCAGGTACCTGTAATCCCAGCTACTTGGG AGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGCTGCAGTGATCCGAGATCACACCTCAGCA CTCTAGCCTGGGTGATAGAGAAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAGGCCGAGCGTGGT GGCTCACATCTGTAATCCCAGCACTTTTGGAGGCCGGGGTGGGTGGATTACTGAGGTCAGGAGTTTTGAG ACCAGCCTGGCCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCATGGTGGAGT GTGCCGGTCCAGCTACTCAGGGAGGCTAAGGCAGGAGAATCGCTTGAACCTGGGAGGTGGAGGTTGCAGT GAGTTGAGATTGCAACACGCACTCTGGCCTGGCCGAAAGAGCGAGACTCTGTCTCAAAAAAAAAAAAATT AGCCGGGTGTGGTGGCACGCACCTCTATTCCCAGTTACTCAGGAGGCTGAGGCACAAGAATCACTTGAAC CTGGGAGATGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACACCAGCCTGGGTGAGAGTGAGACCCT GTCTCAAACAAAAACAAAAGATGAGTATCACTCCTTCAAGCCAAAGGTACTGAGAAAACATCTAAGAACT AACAACTTAAAGTTGTGAGAGATTCACAAAAGGATAATCAAAGCCATATAATGAAAAATATTACAGGAAC ACATGCTGTGCAGCTGGCATTTTGTTCTATTAATCCTGAAACCGAACACCATACTAAGTTTCTGAGGAGG GAAATTTTGCTGCAGAAGGTCAAAACCCCAGCACACCTGTTCTGACTTGAGTGTGAAAGTAACACCTCAC CCTACAGGCCCACCACCCACCTGCCCTGGGGCCTCTCAGCTTCCCCATCACTAAGCCTTACTCTTTCCCT TAAAATCCACAGGGAAGAGTAGCCTCAAAGAACAGAAAATAGATGACATTATTTTGTCCCTTGGGCAGAA GGAGAAGCTGTGGCCTGAGACTCCAGGTCTACAATCATAGGAATATGCCCAGGTACCTTCAAAAAGATGA CTGCTCTTTTGCTTTTGACATCAGAATCAGAGAGCAAGCAGATAGTATGGCAACAAATTTCAACCCCGCA ACAGTGTACTGCCTGTGACACCACACCTGGAAAGAATGACCCTGGCCACCAACTCTACCCTCACCCTAAC AGTGTCCCTCAGTAAAATCTCTACTGGAAATGGAAGTGGCATGGCCTACCTGACTTTAGTAGTGAACTGG ACGCCGGTCTTGATGACGAGGGGCCGGTCAGGATGCATGGGCATGCAGGGCTGCCGCTCCACCACAAAGG CACTGAGGAAAGAGAAGATGGGCTCACGCGCCACGGCCATGACCAGAAGTCAGCCCGCCTCTCACTCTAC CACGTGAGTCTTTAGGTATTTTTTAGATGAGGGAAAGGGACAAGGATGCTAAATTACCTTTTCATTAAGT TTCTAAACAGCTCCACGATTCTCTCCTCCAGCATCGGCCGGTGCTGTACAATGGGGTCCCCTTTGTAGGA AACTTTTTGCTGCAACTCCTCCAGTTTCTTAATTTGTTGACGGGTCTGAAGTTGAGATTCTGCTAATGAC GTTATCCTGCCAATAAATTAAGAAAGATGCTAATTACCAAAGTGAATGTATACAGGTGAGATGGAGAAGG GGAAGGAAATACTGAAGACATGGAGACCACTACAATAAGAACAAGGAATTTTTTTATTGTGGTGAAATAT ATATAGCATGAAATTTACAATTTTTCATCTTAAGTTTACAGTTCAGTGACATTAAGAAAAGAGGAATTTT TCACCATGTTGGGTGGATGCTGAAAAAATAAATAAAAAAAGAAAATAATTTATTTATTTATTTATTTTTT GAGCTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCCATTTCCCGGGTTCAAGTGATTCTCCTG CCTGAGCCTCCTGAGAGATTACAGGTGTAAGCCACTGCGCCTGGCCTTTTTTTTTTTTTTTTTTTTTTTG AGATAGAGTCTTACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAGTCTCAGCTCACTGCAACCTCCGCC TCCCAAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCACCACCACTC CCGGATAATTTTTGCATTTTTAGTAGAGATGGGATTTTGCCTTGTTGGCCAGGCTGGTCTTGAACTCCTG ACCTCAGGTGATCCATCTGCCTCGACCTCCCGAAGTACTGGCATTACAGGTGTGAGCCACCATGCCTGGC CAGAAAATAATTTATTTTACCTTTTATTACTAGTCCCTTCCTAAAATCTCAAATTTCTAAGAGGGGGCTG GGCACACAAGAAGTATTAAAATTTATACCACTAGGAGGCATTGATGGAGTTATCACTGGAAAATGACAAG CATCTGAGCCCAGATATGCAGAACACGAAATATGGAATTTAGCACTTACTTTACTCATCCTAACTTGTCT ATGAACATAAAGACTCAGAAAAAGAGATTAGACAGCTCCCAAAGATGGGTTTGAGCCAGCTCTGTCACAC ACTATCTGTGCAAGCTTTGCCAGGCCCTTCACCATCATGGGCCTTAGCATCCCCTTGCATGAAGAGAAGG GCTTGAACTACATGAGCCCTTTCTTTTCTTTCTTTCTTTTTTTTTTTTTGAGACAGGGTCCCACTCTGTG GCCTAGTGCAGTGCAATGGCATGATCATAGCTCACTGCCTCCTCCAACTCCTGGACATGAGTGATCCTCC TACCTCAGCTTCCTGAGTAGCTAGAACTATAGGTGTGTGCCACCATGCCTGTTTAGTTTAGTTTAGTTTT TTGAGATGGAGTCTCACTCTGTCACCCAGGCTGAAGTGTAATGGCACATGTCTAGTTTTTTAAATTTTTG TAGGGATGGGATCTCACTTTGTTGCCCAGGCTGGTCTCAAACTCCTGGGTTCAAGTGATCCTCCCGACTC TGCCTCCCAAAGCATTGGGATTTACAGGCGTGAGCCACAACACCCAATCCCCATAAGCCTTTTCAATGTC AGCCTTCAACTGATCAAAGGACATGACATTATGTTTCAAAATATTGATAACATGCACAAGGAATAAGTGA ATAGAGAGGGAGAAAAAGCTCATTAAATCTATCTCCAAGAATAGAGATATTAGGCCAGGTGCAGTGGCTG ACACCTGTAATCCCAAAAATTTGAGAGGCCGAGGCAGGTCGATCTACTAAAATACAAAAAAATAGCCAGG CATGGTGGCATGGGCCTGTAATCCCAGCTACTTGGAAGGTTGTGACTAAGAATCGCTTGAACCTGGGAGG AGGAGGTTGCAGTAAGCCAAGATCATGCCACTGCACTCTAACCTGGGTGACAGAGTGAGACTCTGTCTCA AAAAAATTAAAAAAAGAGAGAAGTTAGCATCATTCCATCATTCTTTGATGGTTTATCACTAGTGTAACAA AGACCAAAAGACCAGAAAGACAGAAAGTGAAAGGAGAGGGAGGGGGACCGCTGCAGGGATTTCTGAACTC CTGAGCTCTTTTCTGGCACTTCTATCCTCCCATTCCCAGAACTTAAGCTTCTTCGTTCCCTGGTCAGGAA GCATTTAAAACTGCTTTCAGTAAATTAACAACACTCAGGGTTAGTGAGGATATGAATAGACAGGCATTCT CATGTAGAGTTGCGCTAAATTTCCAGTGCAGGCTCTGTATCTCAAGTTTCTCCTAAGGCAAGCTGGTGCA ACATGCTCACTATAGGGCCTTGCACAGGAAGGGTTGCAGTAAGATATGCTGGATGAAGGTAAAAGTGCAA ATTACAGAAAAGCATATAAAGGAAGATCCTGGGCTGGGCACGGCAGCTCACATCTATAATTCCAGAGCTT TTGAGAGGCCGAAGTGGGATGATCCCTTGAGCCCAGGAATTTGAGACCAGCCCAGGCAACAAAGTAAGAC CCTGTCTCTATAAAAAATTTAAAAATTAGCCAGGTGTGGTGGTGCATGCCTGTAGTCCCAGCTACTGAGA AGGCTAAGGTGGGAAGACTGCCTGAGCCCAGGAGGTCAAGGCTCCAGTGAGCCATGACTGCATAACTGTA CTCTAGACTGGGTAACACAGTGAGACCCTGACTCCAAAAAAAGAAAAAAAAATGATCCTAATATAAACTG TATAAATTTCTATCTTTATGTGTATATACATAATGTGTATATACATAATGACAGATGTCTAGATTGAGCA TCAACTAAATTTTAACTACTAGTACTGCTGATGATTTCATTTAAAAATTTTTTCTTCTCTTGATTAATTT TCTGTATTTGAATTTTTTCCCTTAAAAAGGGCATGTGTCATTTTAGATTACTAAAATAACTAAAATTAAA AGGTTTGTCTATCTGTTAAATACAGTTAAACCAAAAGCCTTAATTGAATTATTAAGTAAAATATACTTAA AATATAATAATATAAATACATTTTTTAAAACAAAGTTTCTCCAAATAAAGTAAAAACTTTATTTTATTTT TATTTTTTTGAGATGGAGTCTCACTCTGTCTCCCAGGCTGGTTGGTGTGCGGTAGTAAGATCTCCGCTCA CTGCAACTTCCATATCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCGCCCAGAGTAGCTGGGACTACAGG TGCGCACCACCACGCCCGGCTAATTTTTTTATGTTTTTAGTAGAGATGTGTTTTCACCATGTTGGCCAGG CTGGTCTCAAACTCCTGACCTCAAGTGATCCGCCCATCTTGGTCTCCCAAAGTGCTGGGATTACAGGTGT GAGCCACAGCGCCTGGCCGAAATAAAGTAAAAACTTTAATTCTTGGGCTAAATTTGAATATGGAAAAGTC CCCACGTTGGAGATATAGTACCAATTCTGTGGGCCTGCAGTTAAGATCAGAATTCAATCTAGCTTTCGAG AAAGAAAGGAAAAGCTTCTTTCATCCTTTACCAGTTTTCTAGCCGATCTAGGCAGATGTTGGGCGGGCCT CCAATGCAGGCAATCTGTTGCCGCCTCTTCCAGTCAGCCAGCTCCTCGTCCGTGAGAGTTTTCTGCACGT ACTCCATCGCTGACAAAAGCCCCGCCAGCTCACTCACGATGCTCTGGTTGGAAACCAAAACAAAGTCAGA AAACATTTCCTCAGACTGTCTCTAACCACATTCTTTAGTCAACTCCAGAGCAGGAACTTCTTAGAAACCA AGCAAGTTCTGCCACAAGACGCTGAAATCCCGCAAGTGAGCGAGACACATGGGGGAAGTGGTCCGACCTA TGCCCTTACTCTCCGCATCTGGTCCAGCGCAGTGAGCATCTGTTCCAGCTGCTGCATCTTCTGCCTGGTC ACTGACTGGTTGTTTCCATTCAGATCTTGCATGTCTGCGAAGGAAGAAAAAACTCCTTGACCTGAGGGAA TACTCCTTGACCTGAGGGAATACTCCTTGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGA CCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTTGACCTGAGGGAATACTCCTGGACCTGAGGGAA TACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGA CCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAA TACTCCTTGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGA CCTGAGGGAATACTCCTTGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAA TACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTTGA CCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAA TACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTTGACCTGAGGGAATACTCCTTGA CCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGGACCTGAGGGAATACTCCTGTCCTTAATGACC AGGCTCCTTTGAGGACCCGTACCTCCCTTGCGCCCCGCCCGCCTTAAGATCTAAACAGAGTTAAGACAAA TGAGTCTTTCAACTCAACAACACAAACTCACTTTCTAGAGATTTTAACATCTCTAATATTCACTTGCCTC CTTGACTCTTGAGGGTTTTATAGTTGAAATCAAAGTCATCCTGGAGATTCTCTACCACTTTCATTTTCTG TTCTAGATCCTGTTTAAAATAAGCAAACAAAAAAACAGAAGTAAAGAAAGATTTCCTTGGGAACAGAAAA TATAAAGTTTCTGAGGAGAATTCAAATGAAGCCAAAACCTCAAAAAAGATACATGCAGGACCTGCAGGCA GTATCCCCAAGAGAAGGCTCCCTGTTGGCCAGGTGCAGTGGCTCACGCCTGTAATGCCAGCACTTTGAGA GGCTGAGTTGGGAGGATCACTTGAGCCCAGGAGTTCATGATCAGCCTGGACAACACAGGGAGACCCCCAT CTCTACAAATTTTTTTTTTTTAATTAGCTGGGCGTGGTGGTGCATGCCTGTGGTCCCGGCTACTTGGGAG GATGAGGTAGGAGGATCGCTTGGGCCTGAGAGGTCGAGGCTGCAGTGAGCTGTGATCATGCCACTGCAGC CCAGCCTGAGTGGCAGAGCAAGACCCTGTCTCAAAAAAAAAAAAAAAAATTAATGAAAGCTCCCTGCCCG AGGCTTGTAACTTGCATCACCTGCACTCTCTTCCGGACATCCTGAAGGTGCTGCTCCAGCATCTGCTGCT TCTCCGTCACCACGGCTGCTGTGGGGTGGTTGGCCTGGCCCCCTTGCTGCCAAAAAGGAGGTCAATGCAC ATGTGAACACAGAACTATGGGGAGAGGAATACCTCTACCCAGCTTCCATCCCACCCTAACTACCCTTCTT GTTTGGCTTGAGACGCTGCTGCCATCACAAGAGGAAGGGAAACAGAGGCAGTGGTGCTGTCACTACACAG GTGACACTACACAGGTCATACCATAAACCCCCTTTATGGCACTAAGAGACCACATGTTCAGCTAAGACAT GGTCTATGCCTTCAAAAACCTCATGGGCAAGTATGTCAAAAAATTCAAAACAATTTATGACAGCAGATGT TGGATGTCTACTTAAACGTGGTGTCCAGTATATTTCTGAGGGATAATAAAAAAAAAGTCCTGCCCTAGGG ATGAAATTCCATATTAAAAGATATTATCTTGGGGAGAAGGGGAGGCTGGTACCTTGGAAAATGTCAAATA GCACATGGAAAAAGAAAAAGAAGAAAGAAGGCTGGATGTAGCAGCTCACACCTATAATATCAGCACTTGG GAAGGCTGAAGTGGGAGGACTGCTTGAGGCCAGGAGTTCAAAACTAGCCTAGTCAACATAGTGAGGCCCC ATCTCGAATGAATAAATGAATGAATGAATTAAAGAAATAACAAAAAATAAATAGCATATGAAACTTAAAA ATTACAGGTTCGTGCCAGGTGCGGTGGCTGATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCA GATTACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCGACACGGAGAAACCCATCTCTACTAAAAATACA AAGTTAGCTGAGCTTGGTGGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGAAGGAGAATCGCC TGAACCCGGGAGGTGGAGGTTGTGGTGAGCCAAGACTGCGCCATGCACTCCAGCCTGAGCAACAAAAGTG AAACTCCATCTCAAAAAAAAAAAAAAAAAATTACAGGCTTGGGCTAGGCATGGTAGCTCCCACCTATAAT CCTAGCACTTTGGGAAACCAAGGCAGGAGGATCACTTGAGGCTGGGAGTTTGAGACCGGCCCAGGGAACA TAGAAAGAGACCTCATCTCAACCAAAAAAAAAAAAAAATTTTTTTTTAACTAGCTGGGCATGGTGGCATA TACCTGTAGTTCTAGCTACTTGGGAGGCTGAGGTGGGAGGATCATTTAAGTCCAGAAGTTTGAGGCCACA CTACAGCCAGTTTTATGGGCAACCATTCTCTTCCTTTCCCATGGTCCCTATCCAAGCCCACAGAATACAA ACTTCTTAGAAGTTTTGGGAAGGTGACCCATGCCCCTACTTCTTCCCACAGTGACAGTGACTCATCTGAT TGGTAAGATGGAGAGAAAGACTCTGTGTACACACAGATCTTCAAAGAACCCAGCACCTAAGCTGGTGCCT CCCTCCTCTCACTCTTGCCTTCCTAGGGCCCACCATAAGCAAGAGCAGCAGCCTGGTTTCTAGAAGCAGG TCTAGAGGCCTATCCCTCTGCCTTGTTGGTCTATGGCAGCTGAAGCTCCATATGGATGGCTGGGGTGGGG TGGGGGTGCTGCTCTGCACATCCAGTCTCTCTACCCCAAGATCTAACTCAGGGCACAGGCATTGGAAAGC CCCTATGGTTACCAGCTCAAGCCACACTTTCCATTCTAGTTTTACCAACAATACAGCTGATGTTTTAACC TTCATTCCTTTCTCATGTCTATTTCTCAAGCAGGACTACACTTAAAGGGAGAAAACATGATTAACGATCA CCCACAGAAACCCACCTCTAATACCTTCGTAAAAAACTGTATTGGCTCCCCACTGCTTCCAGCTATAAAC ATCTCAGGCCAACACAGAAAGCTGTTTCACACAATTGATAACTTCAACTTTCCCTCCCTGTGCCTTGGTC ACCCCAGACTCCCAACTCTTCCCTGCATGCAGTGTGTTTCCACACTCTCTTCCCACCCGCTATCCACTCA GCATGGCCTGGGCTTCAGCCCAAACACACCTGAACTCACTCACCTTCAAATTCAGTTCAAATGTTTCTTT TCCTGAGAAATCTTATTCAACTTCCTTAGACAAAATGACACACATCCTTTTCTGTGTTTTTCTCACTTTG AGTGTTTGTGTACTTATAATCCCAACTAGCCTGACAGCCCTTGGTAGCAGGGATTACATCCACTCTTCTA TCTTTAACCAATTCTAGACACTTAAGAGCATGCCAGGTATTGTAAACAGAAAAAATAGCAGTGAGGCCTG GGTTGAGGCCACAAATAACCAACTTATAGCTTTATATCAGGGGTTGCAAACTTTTTCTCTAAGGGACAGA GGGTAAATATTTTTGGTTTCCTGGGTCATACAGTCCCTGCCACAAATAGCCCTGCCACTGCAGCACCAAA GCAGCCACAGATAATGCATAAATAAATGAGTGTGGCTGGGTTCCGAAAAAACCTCATTTACAAAAACAAG CAGCAGGCTGGATTTGGGCCACGCTCACAGTTTGCAGACCCCTAATCCGTACGATTGAAAACATCCTTGG GATAACTTTGGCTTTCCTACCTCCCATGGTAAGTTGGAGCCTCTATCCAAATTGACTTAAACCACTTATT TTTATCTTGTGGAGCAGGATAAAATACAAAGGTTTTCCACAGCAGAAAATCCTAGTGCTGCCTGAGCAAA TGCCTGTGTGCTAACCTCTTGGGCTACAGGGCACTGCACAGTAAGTGTTACCTACCACCTCGCTCACACC TGAGCATATCAGTTTTCTGCTTAAAATTCCTCACTAGGGCCGGACACAGTGGCTTATGCCTGTAATCCCA GCACTTTGGGAGGCCGAGGTGGATGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAATATGGT GAAACCCTATCTCACTAAAAATACAAAAAATTAGCCCAGTGTGGTGGCTCATGCCTGTAATCCCAGCTAC TTGGGAAGCTGAGACATGAGAATCGCTTGAACCTGAGAGGCAGAGGTTGCAGTGGGCCGAAATCGCGTCA CTGCACTCCGGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAGAAAAAAAAAAAATTCTTCACTGGGTC CCCATTTCCTACAGTAATGGTGAGGGTGATGATAGTGATGTCAGCAGCAGCAGAAAGCAGTTAAATTATT TTGCATTTATGTGTCAGATACTGTTCTAAGCATTTTACATGTATGAATTAATTCTATGAAGAAGGTATTG TTATCACTCCCATTGGAGGAACAGAGAGAGTAAAAATTGTTTACTTAAGGTTACAGAGCAAGTGGCAGGG CTGCGGGTTCAAACCGAAGCAGTTGGCCCCTTGTGGTAAACTGCTCTTCCAGGGCCCCACTGTTAGGCAT GACTAATTAAAACATCATGTGGCCTTGACTAGCTTGTCTTCCCCGACCCAATCAGATGCTGAACTTTCTA CACTTCTCCCAAGAATACACATTTCTGTTTCTGTCTTTGAACATGATCTTCTTTCTGCCTGGAGAGCTCT TTCTCATCAGTTGATGAGCCCAGGAGTTCAACACCAGCCTGGGAAACATGGCAAGAGCCCATCTCTACCA AAAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTGGCATGTGCCTGTAGTCCCAGCTACTCATAAGGCTG AGGCAGGAGGATCGCTAGGGCCCAGGTGGTTGAGGCTGCAGTGAGCTGTGATCACACCACTGCACTCCAG CCTGGGTGACAGAGTGAGACTGTCTCAAAAAAAAAAAAAAAAAACAAAGGTTACAAAGGTAAATTTGAAA TGTAATGTTATGTGTATTTCACCACAATTTTTTAAAAAGCAGGGGGTCACGGAGAAAAAGAAAAAATGTC CCTGATTATAGGATATTAAAGACGGTAAAACCCCTCACAGAAAGTAAAAAAGTCTCCTATGACCGACTAC TTTAATGATTTAGTATATGTGTTTCCAGATATTTTCCCATACATACCAATAGTATATGCAAATTGCATAC ATTTAGTTTTACTACTATGAATCAGATCTTTCTTTTTTTTTTTTTTTTTTTTTCAGTCGGAGTCTCGCTC TGTCGCCCAGGAGTGCAGTGGCGCAATCTTGGTTCACTACAACCTCCGCCTCCCAGGTTCAAGCGATTCT CCTGCCCCAGCTTCCCGAGTAGCTGGGACTACAGGCGCGTACCACCACACCCAGCTAATTTTTGTATTTT TAGTAGAGATGGGGTTTCATCATGTTGGCCAGGATGGTCTCAATCTCTTGACCTCATGATCTGCCCACCT TGGCCTCCCAAAGTGCTTGGATTACAGGCGTGAGACATCGTGCCTGGCCCAGATCTTTACTTTCATTACA TCTTCTAACAGGTTACTGCTGCTACTGATTAGGGGAACTGCAGATTCTAAAAATATTTATCTTGTATACA ATGGCCTTTCTAAACCTTGCTAGTTCCAATTGTTATTGTTAGTTTTGTTTCTCTTGGATCTTCGAGGAAG ACCTATCTATCTGTAAATAATAAGAGTTCTGTCCCTTGCTTTCCAATATTTGTACCCTCATTTCTTTTTC TTTTTGCATAGGCTGGATCCCTCAGAAAAGTATCAATGGTAAAAGACATCCTTATCTTTTGCTGTTTTTA CTGAGAATAGTGTTTCACCACTGTGCATCATGCTCCCTTTGGTTTCTGATAAATATTCTTTCTTGTGTTT AGAAAGATCCTTAATTAAGCCAGGTGCGGTTGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGC GGGCGGATCACGAGGTCAAGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCATCTCTACTAAAAA CACAAAAAATTAGCTGGGTGTGGTGGCGCGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGGGA ATAGCTTGAACCTGGGAGGCAGAAGTTGCAGTGAGCTGAGATCACGCCACTGCACTCCAGCCTGGCAACA GAGCAAGACTCTGTCTCAAAAAAAAAAAAAAGGCTGGGCGTGGTGGCTCATGCCTATAATCCCAGCACTT TGGGAGGCTGTGGCCGGTGGATCATGAAGTCAGGAGATCAAGACCATCCTGCCTAACAAGGTGAAACCCC ATCTCTACTAAAAAAAATACAAAAAATTAGCCAGGCTTGGTGGCACACACCTGTAGTCCCAGCTAGTCGG GAGGCTGAGGCAAGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTAAGATGGCACCACTGC ACTCCAGCCTGGACGACAGAGAGAGACTCTGTCTCAAAAAAAAAAAAAAAGAGAGATGAGGTCTCGCTAC ATTGCCCCAGCTGGTCTCGAACTCCTGAGGCTCAGGCAATCTGCCCGTCTCAGCCTCCCAAAGTGCTGGG ATTACAGGCGTGAGCTACTACACCTGGCTGTTTTTTAGGTTTTGATATGAGGATTTTTCCAGCCTCATAA AATAAGCTGAAAACATCCCTTGTTTTCCTATACTTTGGAAAAGTTTGAATGATATTGGAATAATCTGTAC TATGAAAGTTTGTCAGAACAGGCCGGGCACAGTGGCTCACGCCTGTAATCCCAGCACTGTGGGAGGCTGA GGCGGGCGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGAAGAAACCCCGTCTCTACT AAAAATACAAAATTAGCTGGGTGTGGTGGCACACGCCTATAATCCCAGCTACTCTTGAGGCTGAGGCAGG AGAATCACTTGAACCCTGGAGGTGGAGGTTGCAGTGAGCCAAGATCGCGCCATTGCACTCTAGCCTGGGT AACAAGAGCAAAACTCTGTCTCAGAAAAAAAAAAAAAGAAAAACAAAGAAAATTTGTCAGAACAAAACAA AACTTTTAAACCATTGGGTCTGTTGGATTCTTTTGGTGGAACTTTCTTTTTTTTAGAGTTTTTCAATGTA TTTTGGGGGGTGGAACTTTCTTTTTTTTTAGAGTTTTTCAATGTATTTTTATGATTATTGATCTATTTAA TTTCTTTTCCTTCTTTTTTAGTAGATCTAATAATTTATCTCATTATAAAGTTGTTTGATTTTCCATTCCT CCCAGACCAGGGATTTGTTTTGTCTCAGGTCTCACCTGGGCCGCAGTGGCTGCAGTCTGTAGAAGGCGTG ATTCTTCCCACAGGCACCGGGCCACAATCCGGGCAATCTCCATTGGCTTCTCAAGATACCTGCTCTATAA GTAGGAGAGAAAGAGAATAAAAATCAGCAGCAGACCATGGAGATGTGGACTGAACTGTGGCACCTTAAAA CTAATGTATTCATCAAGGAAAGCATTTATTCTAGGAAACAACGGAACAAAGGCTTCAGAGCCTGGGTGAA GGCTCTCTGTCGGCGGGGGGCGAAGGGGAGGTCGTTACTATTTCTGTAACAGAAGGCACATTAGCCTGAG TCTTTTTTTTTTTTTTTTGAGACTGGCTCTCACTCTGTCCGCCAGGCTGGAGTGCAGTGGCGCAATCACG GCTTATTGCAGCTTCGACCTCCCAGGCTCAAACAATTTTCTCACCTCAGCCTTCTGAGTAGCTGGGACTA CAGGTGCATGCCACCACAATCAGCTAGTTTTTAAAAAAAATTTCTGTAGAGATGGTGTCTTGTTATGTTG CCCAAGCTGGTCTCAAAACTCCCAGGCTCAAGCAATCCTCCCACCTCAACCTCCTAAGGTGTTGGGATTA CAGGCGTGAGCCACCATGCCTGGCCTTGTCTGAGTCTTTACACAGTATACTATCCTGGTCTTGCAGGGAA GCTACTGACTTAGTCAAGAAGTATCCCATTATGGTCAAACATTTAACATGTAACAGTGAGAGTCATCTTC CTATCAGTGGACCGCGTTAACATGCTAACATGTATGATTAACATAACAATCACTTTATTACTTCAACTGT GACAAGAGAAGTGATTCTCAGGTAATGATGCTCACGGGTAAGTATACAGAGCTTTGAGAAAGGGCTAATT ACTTCTCCTGTGATTGAAAATACAAGATAGATTCTCGTTACTTAGCCAAATGAGAAAAGAGATGCTTCCA GGAAAGAACACTAACACCCGACTCTGCGGGTCCTGTTTCTCCTTGTCCTCAGTTTCTCATCATACCTGAA GAAACTGCTTGATTCTTCGTAGATTGTGCTGATAGAGAACATTCGACTCTTGCAGGAAGCGGCTATACTG CTGGTCAATCTCTCCCAGGAGATTATGAAACACCAAAGTGGCATGTGATTCTTTGCTGGCCGCATATGCC CTAGGAAAAGGAAGAATGATAAAGAATGGCTCTGAAGCCGACGCATACACACAAACACAGAAATCACCAT CAAGAAAGAGGAAAAAAACAAAAAAACAAAGCAAACCTGATGCTATAACCCATTCATCATGTTAGATTCT TCTTGCTCAGCAATAAAATGCCATCAATGTAATAATTATTAACAATTATTCCAGGCCAGGCATGGTGGCT CATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACCTGAGGTCAGGAGTTCCAGACCA ACCTGGCCAACATGGTGAAACGCTGTCTCTACTAAAAATAAAAAATTAGCCAGGTGTGGTGGTGGGCACC TGTAATCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATCGCTTGAATCCAAGAGGCAGAGGTGCAGTGAG CCGAGACTGTACCACTGCACTCCAGCCTGGGCTACAGCCAGACTCCATCTCAAAAAAAAAAAAAAAAAAA CCACAAAACAAAAAAACAATTATTCCAGATATTATTACCCACTCTCATAATCTGTTGTATTTGTAAAATA TTTGAGCAAAGTAGACAGATATGCTGTTTTGCTTTAAACCCTCAATTAACTCTGGTCAGATTTATTAGTA CAAATAAGTAATCCCAGGCTGGGATGGCCTATCTCCAACATCTGTGAATCACCTCCTGGCCCTTCACCAA ATCAGAGTATGCATTCTGGAAAAACCAGGTCATATTAACACTGGCCTGAATTAAACCAAAATCAGTAGTG AGCCTGAGCATATTAAAGTGAAGAAAATAGTTGCTGGACATCTGTGCCATTATCTGCTCTATGAATGGAA TCTACTTCCCTTATCCTGTGATCTAGTTTGGATCTACATCCCTGCCCAAATCTCATACTGAAATGTAACC CCCACTGTTTGAGGTGGGGCCTGGTGGAAGGTGACTGGATCATGGGGGTGGGTTTCTCATGAATGGTTTA ATACCATCCCTGTTGATACTGTCCTCGAGACAGTGAGTTCTTGTGAGATCTGATAGTTTAAAAGTGTGTG GCACCTCCCCCTTGCTCTCTTGCTCTTGCTGTGGCCATGTGACCTGCCTGCTCCCTCTCTGCCTTCCGCC ATGATTGGAAGCTTGCTGAGGCCTCCCCAGCAGCAGATGCTGCTATGCTTCCTATATAGCCTGCAGAACT ATGAGCCGATTAAACCTCTTTTCTTATAAATTACCCAGTCTCAGGTATTTCTTTATAGCAAATTGAGAAC AGACTAATACACCCCTGTGGCTCCTTCCTTTAACTAAAGGGGAATTACAAGTATCAACCCAAAGTTCTAG CTATGACAGAATTCACATTCAGAGAAAAAATATGTCTACCACATCACTGGATTATCAGAATATATAGAGG ATCTGCCCAAGTAAATGAGGTCCAAATCAACCTTCAAGACATCCACCACCATACAGGCGGTTTCAATGTG TCAAAGACAGTTGCCCACATGCCCTTCTAAGATAAAAAAGGCTTTACAAGACCAAAGGGTGCCCCTTTAT CTCCTGATCTCATTTTCCCCATCACCTGTACCCATACATTTTTTAATGGAACAGCAAGGCATGACATTAA GAGTTCATGTCTCTTGACTCAAACTGAAACCTAACAATTTGGAGAGTCACTTAAGAAGGACTTACCAATC TTGACTCTCAATCCAAGGGGCCAGAAACTGCCGCAGCTCCATTGGGAAGCTGTCACTGTAGAGCTGATGG AGCTGCTCCAGGTACCGTGTGTCAAGCTGCTGTAGCTGATTCCATTGGGCCATCCTGCTAAAATCAGGGG TCCCAACTGTAAACCAAAGTGTGCATATGTTCACCACAAGTCCCAGTAGGGGTAAACAATCTAGAAGTAG CCATTGCCCAACACAGGTGTCAGGTCTGTGACTAGGGATAAAGATGCTCTGGGGAGGACCCTGCTTCTTT CTCCCAGTTTATTTTATTTTTAAAAAATAGAGATGGGGTCTCTATTTTTTGCCTGTTGCCCAGGGTGGCC TTGAACTCCTGGACTCAAGTGATCCTCCCACCTTGGCCTCCCAAAGTGCTGAGATTACAGGCATAAGCCA ACACACCCAGCCTGTTTCTCCCAGTTTAGAACAATACAAACACATTCACAATCCCCACCTTGGGATAATC ACAGCTCCTTTTTATTATTTTTTGAAGACAGAGTCTTGCTCTGTGGCCCAGGCTAGAGTGCAATGGCATG ATCATGGGCTCAAGAGATCCTCCCACCTCAGCCTCCCGAGGAGCTGGGACTATAGGCACACAACACCATG CCACACTCATTTTTTAAAAAATGTTTCGTGAGACAAACAAAACATGCCCAGGCTGGTCTTGAACTCCTGG GCTCAAGTCATCCTCCTGCCTCGGCTTCCCAAAGTGCTGGGATTACATATGTGAGCCACCCCATCTGGCC ACACATCTCTTTTACACTGGGATGACAAGTGGCTATTATGCCAGGTTCTAGAATCCATTATCTACCAGAA GTGTGTGAAATTAAAAAATTACTTAACTCCCAGATTTCTATTCCCTTGTCTATAAAATAGAGATAATAAT TCCCACTCCTCAGAGGTATTGAGATATTCCTACAGCATCCAGCTCAGTGCATGGCACATAACAGATGCCC AACAAATGTCGGTTCCTTTCTTTCTCCTCCACAGCCCTTTTAGTTATACACAGTAAACCTGTACTGTAGC CAAAATGTAGAAATTGGATGTTTGGGGTTGGGGGACAGAGCACTAATTCCAAGACTACAGGTTTAAAAGT ATAAATGAGGATCCAGGAAGATCTGCCTGAGATTCTCCTACTCAACAAATAATAACTATTTTAAAAATTG CTTAGTCTGGGACAACAGAGAAGGAAAGAAAAATGCCAGGCATAAAAGTTGTCCCAGGTTCAGGAACATC CCAGTGAAATGCTCTGGTATGAGAAACCCAGCCAGCTAATTACCTGTAATCCTCTTTCTGAATAGCATGG GTCATGGAAATATCAATAGAGGCCAAGTTGTTTTAACAAGTTCTAAAATTAGGCCAGGCGCAGTGGCTTA CGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGATCACCTGAGGTCGGGAGTTTGAGACCAGC CTGACCAACTTGGAGAAACCCTGTCTCTACTAAAAACACAAAATTAGCCAGGCGTGGTGGCACATGCCTG TAATTACAGCTACTCAAGAGGTTGAGGCAGGAGAATTGCTTGAACCTGGAAGGCAGAGGTTGAGGTGAGC TGAGATCGTGCCACTGCATTCCAGTCTGGCAACTAGAGCAAAACTCTGTCTCCAAAAAAAAAAAAAGAGA AGTTCTAAAAATAATTACAAGTCAGAGCCAAAGATGAAGGTATGTACAGACCAAGGTCCAATGAGATGGT TCTCTGGGATAGTGAGAACATTTAATGAGAGACTGAACACACGCAAACATACTAGAGTTCTTGATTCTCA GAGAAGGCACGAAGAAGCACCTAGTTAGCACTGGCTTTTTCATAAAAATGACTGAGCAAACTGGCAACAA AACCAGCAGGTCTTCTGTTCTCAAGGCAGCAAATGTAACGGAATGAAAGGTGCGATCGTGGAACCTCTAA CTCCTGCAACCTCTAACTCCTGGGCTCAGGCAATCCTCCTACCTCAGCCTCCCAAGCAGCTGGGAGTACA GGCAGCATTGCTGCACCTGGCTAATTTTTTTAAAAAAATTTTTGTAGAGATAGGGTCTTCACTGTGTTGC CCAGGCTGGTCTCGAACTCCTGGGCTTAAGCAATCCTCCTGCCTCAACCTCCCAAAGTGCTGGGATTACA GGCGTAAGCTACCACGCCTGGCCTGGGATCAGGTTTTCTGACAGAACCTGAGAGGGCTGCACTTCTCCCT CCCTCTTTGGGGGACAGACTCAGAATACCCCTCTTGCTACTGTGAAGACGGCTGGTGGAGCTCTCAAGCA TATATTCAGGGAAGTGCAGGTAGTACCTCCCAGCAGTCTTTACATTGAATAATTAATAATCTAAGGCAGC AGCATCCAACAGAAATAGAATACAGGCCACACATGCATTTTAAATTTTCTGGTAGCCATACTTAAAAAGT TAAAAGAGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGAACTTTGGGAGGCCAAGGCAGGCGGATCA TGAGGTCAGGAGATCGAGACCATCCTGGCCAATATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATT AGCTGGGTGTGGTGGCACATGCCTTTAATCCCAGCTACTAGGGAGGCTGAGGCAGAAGAATCGCTTGAAC CCAGGAGGAGGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGATGACATAGCGAGACTC CATCTCAAAAAAAAAAAAAAAAAAGAAAAGAAAAGAAACAGGTGAAATTAATTTTAATGTATTTTATTTC ATTTAATATATCCAAAATGTTATTGCAACATATGAACATACAAAACATATTATTATTTATTTATTTATTT TTTGGAGACAGGCACTCTGTCACCCAGGCTGGAGTGCAGTGGTTCAATCACAGCTCACTGTAGCCTCAAC TTCCCAGCTCAAACGATCCTCCCACCTCAGCCTCTCAAGTAACTGGGACTACAGATGCGCACCACATCTG GCTGATTATTTTTGTAGAGACGGGGTCCTACTGTGTTGCCCAGGCTGGTCTCAAACTCCTAGACTCATGC ATCTCAGCCTCCCAATGTGCCAAGAGTATAGGCTTGAGCCACCGTGTCCAGCCCACAAAAACTATTAATG AGATACTTTACACTCTTTTTTTTGCTACGAAGTTTTCTAAATCTCCTGTGTACTTTACATGTGCAGCACA GCTCCAAGGTATTTTCCCTCCTCATGTATCAAGGGCTTAAATTCCACTGGTGAAAAAGCTCAGTAAAGCA AATAGAGAGAATGTCAGAATAAGGTATTTGCCCCAATTAGGCCAATACGCTTCTATAAATTAACTAAATA TTCCAACAATGTTATTTTGTTGTTATTGTTTTTGAGATGGAATCGCCTAGGCTGGAGTGCAGTGGTGCAA TCTCACCTCACTGCAACTTCAGTCTCCCGGGTTCAAGCGATTTTCCTGCCTCAGCCTCCCAAGTAGCTGG GATTATAGGCACGCACCACCATGCCCAGCTAATTTTTTTTTTTGTATTTTTTAGTAGACAGGGTTTTACC ATGTTGCCTAGGCTGGTCTTGAACTCTTATCAGTTCAAGACCAGTCTGGCCAACACAGTGAGATCCTGCT TATAATTAATTAATTTAAAAATGTAGGCTGGGCACGGTGGCTCACACCTGTAATCCCAGAACTTTGGGAG GCCGAGGCGGGTGGATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCGTCTCT ACTAAAAATACAAAAATTAGCCGAGCATGGTGGTGGCCGTCTGTAATCCCAGCTACTCAGGAGGCTGAGG CAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGTAGTGAGCCGAGATCGCACCACTGCACTCCAGCCT GGGCAATACAGCAAGACTCCCTCTCAAAAAAAAGCAATGTTACTTGCCACCTTCCACCCTAAGATTCACC TGCCACAGGACAAATGCTGCCTGGGCAGTGGTACAGGTACACTAAGCACTAGCCAGAGTAAAAGCAGTGG CTGACGTGCATACTATATGCTGAAGCATTGTAACCATGGCATGTATTGATTGCCCTCTGTAAGAAATCAA AGGCCATTAGATCTCTCTTACAATATTTGCATTAGGGCCAAGTTAAAATCTGCCTCACATGGAGGTTGCA GTGAGCCAAGATTGTGCATCTACACTCCAGCCTGGGTGACCAAGTGAGACTCTGTCTCAAAAAAAAAAAA AAAAAAATCTGCCTCATAGACTAAAAGCATCATGACCTGACTTATGCTATGCAAGAACTGATGTGCATAC AAAGAAATCTGCATAATATGCCAATTTATGTAGATTCTATTGCATACAAATTTACTGAAACTCTAAACCT ACACAGTCCAGTATGGAGTCACTAGCCACATGTGGCTACTGAGCACTTGAAATGTGGCTGCTTCAAACTG AACTATGCTGTCAATATAAAATACACACTGGATTTTGAGGACTTAGTGAAAAACAAAAGAATGTAAAGTA TCTTGTTCATGTTGAAATGATAATATTTTAGATATATTGGGTTAAATAAAATATATTATTAAAATTAACT TCACCCATTTCTTTTTACTTCTTTTAATATGGCTACTAGAAAACTTAACATTGGTAGGGCATGGTGGCTC ATGCCTGTAATCCCAGCACTTAGGGAGGCCAAAGCATGTGGATCACCCGAGGTCAGGAGTTTGAGACCAG ACTGGCCAACATGGCAAAGCTCCATCTCTACTAAAAATACAAAAATTAGCTGGGTATGGTGGCACATGCC TGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGG GCCGAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTGCATATCAAAAAAAAAAAAAAGA AAGAAAGAAAGAAAGAAGAGAAAAGAAAAGAAAAGAAAAAGAAACTAAAAGAAAACTTAACATTACATAT GTGACTTGGATCTTATTTTTATTGAACACTGCTACTCTAGACAATGTAGCCAAAAAGCGGTGGTTCTCCT AAAAAAAAATGATTTAAAAAAAGAACCAACTGCTTTTTGTAATAAACTCCAGTGTTTAAAATTAATTTTA AAAACAGACTTTATTTTTTGAGACAGGGTCTCTCTCTGTCACCCAGGCTGGAGTGCAGTGGCAAATATAG ATCACTGTAACCTCCAACTCCTGGGCTCAAGCAATCCTCCTAACTCAGGGACCTGAGTAGCTGGGACTAG GGGCACAAGCCACAATGTTCAGCTAATTTTTTGTAGTTTTTGTAGAGACAAGGTCTCATTTTGTTGCCCA GACTGATCTTGAACTCCTGGCCTCAAGCGATCCTCCCACCTCAGCCTCCCAAAGTGCTGGGACTGCAGGC ATGAGGCATCATGCCCAGCCAAAAATAGACTATTTAATTATTTGTCTTGGATACAAATGCAGAGGCATCA CAGTCTACTCCCTGAAGGTCCAAATTAAATCATGAAACAGCATCCCACTATACCTGCTCCATCATAGATT AACACTGGGGTCATGCATGAATATTTGCATTTTCAAACTAACATATCCTAAAAACGTGTAAGTTATTGAA AATTATCTAATTCATTTCCAGTACATAACTAAGGATTTTTTGGTTGTTGCTGTTCTTATTTTTAGCTGGG GACAGAGGAGGGCTAGTAAGTAGTACAATAATTGTGTTCTTTTTTTTTTTTTTTTTTTTGAGATGAAATA CTGTCACCCGGGCTGGTGTGCAGTGGGGCGATCTTGGCTCACTGCAGCCTCCACCTCCCAGGTTCAAGCG ATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCATGCCCCACCACGCCCGGCTAATTTTTGT ATTTTTAGTAGAGACGGGGTTTCACTATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCGTGATCCGCC CGCCTCGGCCTCCCAAACTGCTGGGAGTACAAGCGCAAGTCATGGCACCCGGCCTGTGTTATTTCTTAAA ACAGAAACCAGCTAGTAGTTTTTTCCATAAAATTAAAGCACCAGGCTGGGCACAGTGGCTAACACCTATA ATCCCAGCACTTTGGGAGGCTGAGGTGGGCGGATCACAAGGTCAGGAGTTTGAGACCAGCCTAGCCAATA TAGTGAAACCCTGTCTCTACTAAAAATTCAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAGTCTCAG CTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATCGT GCCATTGCACTCCAGCCTGGGCAACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAGAAGGCACCAGGG CACCAACAATGACTGATTTCATGTTTTACTTCTTAGTCTAATCACCATAGGTAATACTTTAATAGTTATT CTACAGGGGAAAATAAAAGTATAACTTAAAGCCAAAGACCAGGTAGTATTTTCAAGGAGAGAATATGCAA ATACTTCCATAGTCTTCTCCTTACAGGCTGCTTAGCTACAAACCATATTTAATTAACAGCAGTCACAGGA GATGACTAGCCAAAGTGTCTAGGAAAATCACTGCCAAGCAGCTTTACTGTAACTGTTTTACTGGAAAAGA CCTCAAAGAGCCCATGTTATTTCACAATTTCAATTTTGGTTTTTCAAATTACAAGTTAATCTAAAGAACT CCACTAAGTTCTAACTACATTACTTCATATCTACGGAATAATTCTAAGCCTGTGGGTTTTTAAAAAAATT TTATTAGACATTCTAGAATTGGGCAACACTTCATTCAATGCCATAGGATGAATGTTCTCCCCAAGCCTGT GACTTAATAACTACTTCATTGAGCCCCAGAACACACAAAGTTATCTGAGGAACAACTTGAGTGCCAACTA CCACTCTGGGTGCATAAGAGAGAAGACAATTCATTACTCCATATAGGCTGCCTTAGGACATTATATGGGG CTCAATTCAAAGCATTTACTCAGGTTAAGTCAGCAGATAGTAGATGCACTGTACAAAGGCAAGGTGGGTG TAATCCTGTTTTCTATAACTGAAGAGAAAAGAAAAAAATGAAACAGCAAGTCATCAAAGACTTTTTGGAC TTTTCAAAACAGGAATTTCTCAGTCCCTTGGGGATAACCTACCAACAGCAAGTCATAAAACAAATAACTA TTGTCTAATTGGGAACTTATTACCGTAAAGATGACTGAAAAAGTCTGTCCAAAGTTACAGTTCTCATTTA TATACTTGAATCTAATGAAACCAAAAGATATATTGAGAAACGCAGTCAAGACCACTTACAAAAGGGATTT ACTACACAGCTTCATAAAACTTTTTAAAGTTAAGACTTGTACTTCACATCCATGCACTAGTGGATTTACA ACGAGGGTGAGGGAAGGCGGAAAGAGAGACGAAAATCAGGCTCATACAATAATCCAGAACAGAAAGTGAT CTAAAGATAACTTCTGTTCCACTTTGCAATGTGTCATGACATTTTCCTTTGGGTACCACCTATACTTTTA TTATAAATACATGCATTTTAAATAGAGCATACCTGTGTTTTATCTGCTGCCTACACTAACCTCTTCTTTG CTGTCAGGAAAGGCCCAGTGATCAAGGCAACCAAAGTATAAAGAAACACAGAAGATTTCTTGCACTGAAT TCTATAGGAACCAGTCCTTTTAAGAGATATGTTTGAAAGATTATAAAATAATGTTCAATGTGGAAAATTT AGAAAAATATAAAAAAGAAAATAAAAGATAAAAACATCCATATCCCACCATCCCACTATGCAGAACAAAA ACTGACATGTTGCCAGGTGTGGTGGTCTGTGACCCCAGCACTTTGGGAGGCTGAGGGGGGAGGATCACTT GAGGCCAGGAAGTCAAGGCTGCAGTGAGCTGTGATTGCACCACTGTACTCCAGCTTGGGTGACACAGCGA GACCCTGTCTCCGAAAAAATAAAAATTGACATGTTGATGTAATTCCTTTAAATCTATTTCAGAATGTGTT TGTGTGTGTGTATATATATATATATATTTTTTTTTTTTTACATTGGAGTCATAGCATTAATACAGCTGCA TATTCTTTTAAAGTTTATTGTGTAGTAAACATTTTTCTATGAAAAGAGTATTGTGTTTGTTTGTTTGTTT GTTCAAATAGAGACCAGCTGCCCAAGCTGGTCTCAAACTCCTGGTCTCAAGCGACCCTCCTGTTTTGGCC TCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAGTACCTGGCCTGAAAAGAGATGTTTTGTTATTGTTG TTGTTGTTGTTTGAGACAGAATCTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCACCATCTCAGCTCAC TGCAACCTCCATCTCCTGAGTTCAAGTGATTCTCATGCCTCAGCCTCTGGAGTAGCTGGGATTACAGGCA TGCGCCATCATACCCGGCTAATTTTTGTATTTTTAGTAGAGACGGCGCTTCACCATGTTGGCCAGGCTTG TCTTAAACTCCTGACCTGAGGTGATCTGCCTGCCTCAGCCTCCCAGGGTGCTGGGATTACAGGTGTGAGC CACTGCGCCTGGCCTGAAAAGAAATTTTTATTTAAAGCGCATAAAAGAACTATTTTGTTTCTATTGGTGT TTTCAATACAACCCTGCTAATCCCACTGAGGGCCACATAATTTATTAAGATTTGGAAACCCCAATTTATT TGTTCTCACCATACCACGTTCTAAAAATAATCTGAAGTATCTGCAAGTAGATTAGGAAGGAAAAAAATGA GAAAAGTAAGAGAAAGCAATTCACGCTAGAGAAAAACATTCAATCTTCATAAAATTTTCACCACAGGATA AACAGCATAATGGATGACAGAGAGTCCACATTAAAATACTGTAGGCCAGGTGTGGTGGCTCATGCTTGTA ATCCTTGGGAGGCTGAGGAGGGTAGGTCACCTGAGGTCAGGAGTTCGAGACCAGCCAGGCTAACATGGCA AAAGCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGAAATACACCTGTAATCCCAGCCACT TGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGCGAGGCAGAGGTTGCAGTGAACCAAGATGGTGCCAC TACACTCCAGCCTGGGCGACAAGAGCGAAACTCCATCTCAAAAAATAAATTAAATAAATAAATAAATAAA TACTGTAGCTTTAAACTATTAGAGTCATTCATAATTTAACCATTCATAATTACTCTAGACATTAAGAATG GAATTTCAAGTTTAAAACATAACTCAAAATAAGTACACTTATATAGTAAGCACACAATTTCATAGTTTTA AGTCCAAATAGTACCTTTGTAAGATTTAAGACTAGATACTTGCAATAAGAAGTCTATATATAAATCTAGT TTTGATTTCCTAAAGAGACAAAATATTAACACTTGAGTGCCCAATCTGAAACAAATTACTATAATTACTG TAATGTTCAATTACATATAACAGGATTTGCTTTAAAATTAAAAACCAATGACGATCAAGCTTGTAAAAAT GAACATCAATCTATAAGAAAACTTGAGTTATAGTTCCCTACTAATATGACAAAATTTGAATATATGAAAG AAGTAAAGGCCAGGCATGGTGGCTCATGCCTATAATTCTAGCACTTTGAGAGGCCAAGGTGGAAGAGGGA TTGCTTGAGCTCAGGAGTTCAAGACCAGCCTGGGCAACACCGTGAGACCTTGCCTCTACAAAAAAATTTT TTTAAAATTAGCCTAGCATGGTGGCCCATGCTTGTAGTCCCATGGAGGCTGAGGCAGGAGGATCACTTGA GCAGATTGAGACTGCAGTGAGCTGTGATCATACCACTGCGCTCCAGCCTGGGTGACAGAGCTAGACCCCA TCTCTAAAGAAGGAGCAAGAGCTTAACAAACCTAATTCCCTCTAAATTAAAAGTAACAAACATGATTTGT CAATTACTGAGTGCACAGTTGATTGTTAAAGCTGCCTAAGAACAGGTCTGAGCTCTACAAAAACTAAAAC TAAAACAAGAAAACCCACAAAACAGACCAAATTTGTGCATCAGATGACCTCCCCACTTGGGAACACTTCC ACTTCCCCAACCAGACACATTCCTCTGTATCAGTGTGGTGTGGGGGAAAGGACAGTAGAGACGGGAGCTG GATGGGCCTGGGTGCAAAACCCTGCCTGACATTTATTAGCTATTTGTCTTTGGGAATGGTATTTCACTAC CAAATGGGCTTTCTCTTCAGTAAAACAGGGAACTCTCTCTCCTTTGAAGAACTGTTGTAAAGTTAAAATC AATAATGGTTGTACAGCATCCCTCTGTGCTGGTGCTGCTGGTGCCAGATCCTCAGAGCTGCAGTTATTGT TCCTTTCCCCCAGGGTCTCCCTTTCATGGACATTTCTTACTTTTTTTTTTTTTTTTTTTGAGATGTAGTC TCACTCTGTTGCCCAGGCTGGAATGCGGTGGGCACAATCTCAGCTCACTGCAAGCTCTGCCTCCTGGGTT CACACCATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGACTCCAGGCGCCCGCCACCACACCCGGCTAAT TTTTTGTATTTTTAGTAAAGAGGGGGTTTCATCGTGTTAGCCAGGATGATCTCAATCACCTGACCTCGTG ATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTAAAGCCACCGCACCCAGCCAGATATTT CTTATCTTAAACCCATTTCCTTAGTGTCCTGGAAAGCAGGTTAATCCATCAGATTCACTAGGGGTTAAGT GTGATAATCACTAATCAGCTTTCCCTGCTAAGTAAAATACATGCATTTCAATGCACACTCTTATCATATC GGGAGGGAAGGAGTCAGTGATGCTGTGATTTGGCATGTTAATTTAAGGAGAGAAGGGAGGTCAGGAGAGC TGGGTGGTGACCTGATCAAATATCTCCATACGTATTTCACCTAGGATGGCTCTAGGTCCTAAAAAGAGTA AAAGGTGAAAACACTAAGTGATATTCAAAACAAAAGAAAAAGATGAAAAATAAGAACCTTGGTTAAAGAG CAGTCGAAATAAGTAATGATTATAGCTATGATTTATATAGCACTTTTTACAAGAAGCCAGGCGCTGTTTT AAACACTTGACATACTTATTTGCTCATTTCATAATTGTAACAACCCTATCAGATAGGTACTATTTTTATC CCACTTTACAGAGGAGAAACTGAGGCACAGAATTTTAAGTGATTTGGCCGGGTGCGGTGGCTCACGCCTG TAATCCCAACACTTTGAGAGGCTGAGGCGGGTGGATCACGAGGACAGGAGATCGAGACCATCCTGGCTAA CACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGTGTAGTGGCGGGCACCTGCAGTCC CAGCTACTTGGGAGGCTGAGGCAGGAGAATGGTGTGAACCTGGGAGGCAGAGCTTGCAGTGAGCCGAGAT CGCGCCACTGCACTCCAGCCTGGGCGGCAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAGA TTTTTAAGTGATTTATCCAAAGTCACAACACAGGTAGTAAAGGCATGGAGCTGGAATCATAACGCACAGT CTGTTTTCGGAATGTCTGTTCTTCACCACTATAGGAGTCTTGTTTTTTCTTTTTTTTAAATTAGAGATGG CGTCTGGCCATCTTGCCCAGGCTGGTCTCGAACTCCTAGGCTCAAGCGATCCTCCAGCCTCAGCCTCCAA AAGTGCTGGGATTACAGATGTGACCCACCGTACCCAGCTACTACAGGAGTATTAGAAAGTGGGAATTTTG GCCAGGCTCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGT CGGGAGTTCGAGACCAGCCTGACCAACATGGAAAAACCTCATCTCTACTAAAAATACAGAATTAGCTGGC CATGGTGGCACATGCCTGTAATCCCAGCTACTCAGGAGGCTAAGGCAGGGGAATTGCTTGAACCTGGGAG GCAGAGGTGGCAGTGAGCCAAGATTGTGTCATTGCATTCCAGCCTAGGCAACAAGAGCAAAACTCCATCT CAAAAAAAAAAAAAGAATTTTAGTTGATTTTTAAGTAACCCACAAACCAACCATTGTAACTAGCCAATGT GATCTTATGGTATTTTAATAGACATACTAGTACTTGGATTTTGAAGGATCTAGTAGTCTAGCTGTAACAG ACCCACATCTGGATGCTATTCTAATTCTGTGTATCAAAATTGAAATGGAACACTAAAACAACCAAACACA TCCAGGGAGGGACAACCAGGGTGTGAGGAGTTGAAGACCTTGAATATTTTGCTCAGCAAGAAGATGCAGG CAACAGGAGTGAGGTTAGGAGAGAAAAACATGAATTACAGAAGAGTGGCCCCTCAAATACCTGGAAATCT GTACGAGAAAGGATAAATCACTCTAGGACTAGAACCTGTCTCCTCACAACATCTTCTCCCAAATTCTTCC CCATGAAGTAATACAGAGGTCTCCACCCTGGCTGACACTAAAAAATATATACAGCAAGAAAGATGCCTGG GAACCAAACCAGTGCCAAATTGGAACCTCTGACAGTGGGACCAGGTTTCAAATTTCGAAAGCTACGGCTG GGCACGGTGGCTCACACCTGTAATCCCAGCACTCTGGGGGGCCTAGGTGGGTGGATCAGCTGACGTCAGG AGTTCAAAACCAGCCTGACCAACACTGTGAAAGCCCACCTCTACTAAAAAATACAAAAACATTAGCAGGC ATGGTGGTGGATGCCTGTAATTTCAGCTACTTGGGAGGCTGAGGCAGGAGAATCTCTTGAACCCGGGAGG CGGAGGTTGCAGTGAGCTGAGATCACGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCTGTCAA AAAAAAAAAAAAATTCCTCAGATGATGCTAAAGTGAGGCCAAAGAATAATAATAAATTTTTTCGTGATCA TTAATAAATATAACGAGAACCTCGAAATCAGAGCAGAGATCAGGGCTCAACTCTGAATACGCCTCAGAAT CTCCTGAGGAGCTCTACAAAGCCAGGTGCCAGTTCTTAGCCCAGAACTAGCAAATAATAATCTCCAGGGT TCTAATGAAGCAGTACACTGTAGAGACTGTACAAGGAGACCACGGCAGAAGAGGAGGCTGGAGAAGGCTC TCCTGTCAAGATATCTGCACTTTCTTCCAAGGGCAATGGGGTAAGTCTTTGAAAAGCTTTAAACAGACAA GTGATAGTTTGATTTACATTTCAAAAAGATCCCTCAGGCTGCAATAATCCTGGTGGGAGGTCGTGGCTGC CCAATTTAGGTAGCAGCATTGTAAGTGTTTTGAGGCAGACATCCATCTTCTGTGACATTACAGAGCTACA TGTGATGGGACTTGGTGACTGACTGAAGGGCAAAGGTGACTCAGAGAAAGGGAGGAGTAAGTGACAACCT CCCAGGTTCCTGTGGCATTTGGTATTCAGATGGCGGTCACATGCTCAGCATGGTAAATGTCATGGCAGGA GTGCCAACATTGAGAGGGCAATTGGGCCACACAGTCTCTAAAAACTGTTTGTTCTATAAATTACTGTCAA GCTCGATTCCCTCAAGACATTACAGCCACAGCAACTCAAAATAATACTGTAGGAAAAGCAAGTAGATATT TAACCAAAAAGGGTTCAGGGTTTGTACTCCAGCTGAATGGTAAAACCTGCCATCCCCTCAGGAAAAGAGG CAGAGGCAAGAGAAAAATCAGGCAGAAACATCAGAGCCAAAATGCATAGGGGGCCATGGCAAGAGCTGTT AACTGTCTCCCAACATCTGTGTGCTTGCCTCCAGGCCATTTTCCACACTGTGGGTAGAGAGACCTTTTCA AGACACAAACTTGATCTTGCCACACCCCTACTTAAAACCCTCCTGATGACTGCTCTGTTCTTAGGCTAAA AAACAAGATTTGTTATCTTAAGGCAGAATAGCATGGATTTGAATCCTGGTTCCACCACTTCGATCACTTA GCGTGTAGCTGGTGCCAGTTATTTATCCTCTTTGTGCCTTAATTTCCTCATCTATAGAAAGGGGAGAGAA CAGTGCTTACCTCACAGGGTTGCTGTACAAATTCATCGAGCTAATGAACACGTAGCACTCAGGAGCCCAA TAGCGTGCAGCATGTAAGTGTTTGTACTCATTACTAGCATGACCGACATCCTGGCTGGCTCTGCCCCTCT CGTATGGCTGGTACCAGCTGGTGGCTAAGTTCCTGGCACTCACTCTGCTCCTTCTTCAGGTCCTCAAAAA CACCAGGCTCCTGCCTGCCACTGGCCCTCACACATGCCTTCCTTCTATCACCATCACCATGACTTGCACC CAAGTACTGTGACTCCATTAACTTGGACTCATAACCACTATGCTGGACTGAAAGCCCCATGAAGACAAGA AGAGTCTTGGCTTTTGCTCACTAGCGTGTCCTACCCTGAACCCTGGCATCCAGCATAGTGTCTGGCTCAT AATAGGTGCTGAAAAAATAGGTATTGAATGAATGAACGACTGGAGTGAATTACAACTAAAGTGTGTAGCC AGGTTCTCCCAAGTGAGGACACTGCGCCCAATTAGAAAATATTCTGAGGAATAGGCCAACTCTTCCAGTT TTGCTGTTTGAAAAATTCAAGAATGATCAAGAATCACTGATTCAAGAATAATCCTTCAGTGATTCTTCAA TAAGAGTAAAATCACAGCACTCCCCAGCTCAAAAACACACACTAACATCTCATTGTCCAATGCAAAATCT TTACCCTTATCTCAGGCTCTGTAACTACTCAGCCAACTTTAGCCCCTTCCAGTTCCTCTCTCCAGCCTAC AGATGACTTTCATTTTTTGAGACAGGGTCTTGCTCTGTTACCCAGGCTGGAGTGCAATAATACGATCACA GCTCACTGCAGCCTCAACCTCCTGGGCTCAAGCAACCCTCCCACCTCAGCCTCCTGAGTAACTGGGATTA CAGGCACATGCCACCATGTCTGGATAATTTTCTTTTTTTTTTTTTTTTGGTAGAGACTCAGTCTCACCAT GTTGCCCAGGATGGTCTCGAACTCCTGGGCTCAAGTTGTCCTCCTACCTCGGCCTCCCAAAGTGCTGCGA TTATAGGCATGAGCCATGGCACCCAGCCTCCAGGTGACTTTCATAAGTGTTGTCTTCCTTCAAGTCAACT TATCTCCTCCTTGCCCCCCACCCACAGACTTTGTTCCTTTTTCATATTTGTTCTTGCCTAAAATGCTTTT TTCTCTGGGTGGCGTTATCCATCCCTTTCTTGTGTCTGTCAGACAGGCTCTCCCTAACCCCACCCCTAGT CCAATGACTGCTTTCACTCTGAATCCCCACGGTACATATATAAGCATCTGAGGCTCTTTCCTATTGGCTT TGATTCTACCTCCTTCACTTGAGGAGCAGCTCTCTGCTGGCAACCACGTACCATCCTGATTTAGAACTTC CCACAGGCTAACTTAAGACACCAAATAAACACTTGCACACACACATAACCACCACCTCCCATTACAGAAG TACACCTCCCCTACTGAACAGATGATGGCCACGATACTGAAAAGCATGGCATCAACATGACAACTGCATC CTGAAAGATCAGCCTATATATAGGTTTGGTTATCTTGAATTTCGAGTTTGGAGAGAAGCAAAGTATTTTT CTAATAAACTGTGAATGCTGAGGAATTCACCTTCATAGGAGTCAGAAACAGGCTGCCAAACTTTTCAAAA GAAAAACAGTGGTAGGTTGAGCAAGCACATTGTCATGTCAGATTTTCCAGGCTCGAGGGCCACTGAAGGG AGAAGAGCGAGTAGCTGGAAAAAACCTGTGGGTACTGTTATCTTTGGCCAAAGCTCAAATAAAAGAATCA CAAAAACATCCACTGATCTAAAATGCTATGTAAGTCATTAATATTCATCTAAGAGAGGCAACTGAAATAA AGCAGATAAAGAGAACTTAAGCCATTCTCTTACCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCGC CACCACACCTGGCTAATTTTTGTATTTTTCGTAGAGATGGAGTTTCACCATTTTGGCCAGGTTGGTCTCA AACTCCTGACCTCAAGTGATCTGCCTGCCTTGGCCTCCCAAAGTGTTGGGGTTACAGGCGTGAGCCACTG CGCCTGGCCAAGAATTTAAATTTCTGAGTCTCAAAGTCATAAACCTATAATATGGCTCAATGCTTACCTC AGTGCTTACTGGAGAGAAGGAAGATTCTTTTCTCAAATTTATTCAGGTCACTTTCCCTATACGAAATACT AAGGTAGTCCTGGTCACTTACATGGAACAATATACCTGGGGCTGACGATGCTTGGATATATAGAAGTCCT TCAGTCAAAGGAACTATGAACTTTTGAGGCAGAACCTCAAATTCAGAAGGCATTTGTGGTGGTTGGATAA CATGGCCCTAAATTCTCTCATTATGCCCCACTCTCTGAGAGGAGGGGGTCTTTGTTCCCTTCCTTTGAAT CTAGCTAAGTCCATAACTGTTCCAACCAATAGAGCATGCTGAAAGCGGCGAGATGTCATTTCCACCTGAT TTCATTGGAAGTCTCATTCTCCAGAACCAGCCACATTCTGTGAGAAACCCAAGGCAAAAGGGGAGGCCAC AAGTAGGCACGTGGTCTACAGTCTCAGCTGAAATCAGCCTTTGAGTCATCGCAGCCCAGACATCAGATAC AGGAGTAAAGAAAATTCCAGATGATTATTACCCCCAGCCGCTTGAGTTTTCTCAGTGAGACCTCAGACAT CGCAGAGCAAAGACAAGCCATCCCTGCTGTTATCTAAATTCCTGCCCACGGCATCTTCGAACATAGTCAA ATGATTGCTGCTTTAGGCCACTAAGTCTGAGCTGGTTTATTGCATTCGGCAACTAGAACAACATTTTTAC TAACATAGTGATTGAATGTAGACTTAATAATGAAAGAGTCCAACTTCCATAAGAAAAAAATTCATAATTT TAAAGGAAGAGGCTTTGCTGTTAAAGTTTTTTTTTTTTGTTTTTTTTTGTTTTTTTTTTTGAGACGGAGT CTTGCTCTGTTGCCCAGGATGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCCGGGTT GAAGTGATTCTCCTGCCTCAACCTCCCAAGTAGCTGGGACTACAGGTGCCCGGTACAACGCCTGGCTAAT TTTTGTATTTTCAGTAGAGACAGGGTTTCACCATATTGGCCAGGCTGGTCTCAAACTCCTGACCTTTTGA TCTGCCCACCCCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTGCCCGGCCTGTTAAAGCT ATTTTAATAGTAAACTTATTTTCTCTATGCACTCCTTTCTAAATTATTCAGCCCCACTTTCTTTCAAAAC AACGTTTATACACTGACAATTCTCAAATTTATGTCTCTAGCCCCATCCGCTAATATGAACATCAGACACT TATAGCCAACTGCCTCTTCAATATCTCCACCTGGATGTCTAAAATGCATGTCAAACTTAATGTATCCAAA GCCAACCCCTTCATTAAAAACCTCTCCCAGCCGGCTTCTCCTCCAGTCTCCCCCATTCTAGCAAGTGACA ACTCCATTCCTGCACATGTTGAGGCTAAAAACCTTGAAATGAGCCTTAACTTCAACTCCAGTCTCTCTCT CTCTTCCTCCCCCTCCTCCTGCCACACCTAATCCATTAACAAATCCTGTTGGCTCTGTCTTCAAAATCTG GAAGTGACCGGGCACAATGGCTCAGGCCTATAATCCCAGCACTTTAGGAGGCTGAGGCGGGTGGATCACT TGAGCTCAGGAGTTTGAGACCAGCCTAGGCAACATGGCAAAACCCTGTCTCTACGAAATATACAAAAATT AGCCGGATATAGTGGCGCAAGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGTGGGGGTATCACTTGAGC CCAGGAGGCGGAGGTTGTAGTAAGCTGAGATTGCACCACTGCACTCCAGCCTGGGAGACAGAGTAAGATC CTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAGGAAGGTGAGCCTTTCTCACAACCTCCCACTGACGCAGC CTTAATCCAGGCCACCAGCATCTCTTACCTAGATAGCTGGACTAGGCTAACTGGCCTGGATGCTTTCATC CTTGTCCCTCTACCTTCTATTCTCCACATTACAGATCCTTTCAAAATAAGAGTCCTGGCTGGCACGGTGG CTCAAACCTGTCATCCCAGCACTTTGGGAGGCCAAGGCGAGCAGATAAATTAAGGTCAGGAGTTCGAGAC CAGCCTGGCCAACAAGGTGAAATCCCGTTTCTACTAAAAATACAAAAATTAGCCAGGTGTAGTGGCAGGC GCCTGTAATCTCAGCTACTCGGGAGGCTGAGGCAGGAGAAGTTGCTTGAACCGGGGAGGCAGAGGTTGCA GTGAGCTGAGATCGCGCCACTGCACTCCAGCCTGGGTGACACAGCGAGACTCCGTCTCAAAAAACATAAA CATAAAAATAAATAAAAAATAAAAATAAAAACAGAAATTCGCCGGCATGGTGGCCCAAGCCTGTAATCCT AGCTACTCGGGAGGCTGAGGCAGGAGCATAGCTTGAACCCAGGAAGTAGATGTTGCAATGAGCCGAGATT GCGCCACTGCACTTCAGCCTCGGCAACAGAGCAAGATTTTGTCTCCAAAAAAAAAAAAAACCAGAGTCAG ATCATTTCATTCCCCTGCTCAAAACCCACTCAGGAAAAAATCCAAAGTCCTACCACGGCCCACCAGTCAA TCCATTTTGCCCCAGATGTCTCTCTTTGCCTCCTTCCCTACAACTCTCCCCTTGCTCACAGCTGTCCCCT CTCTGCTCCTGGAACACACCTTGCCCGTTTCTGCCCTAGGACTCTTCTCTCCACCTGATAGGCTCTTTCC CTAGATATCTCCATGGCTTGCTCCCTCACTTCGTTCAGGTCTCTGCACAATGTCTCTTGACACCCCTCTA TCTAAAACAGCAACATCTCCCCTGCTGAATTCTCCTTTACAGTACTCATCGCCCTCCATTGTTCATATAT TTCTTTTTTCATGTATCTCCTTCCAATATGATCAACTAGGAACTTAAGCCCCATAAGAACAAAGACATTC TTCAGTTCACTGCTATTTCCCCAGCAACTACAGAATGCTCAAATATTTGAATAAATGAATGAAAATTAAG TAAGTTTTTCAAAAATCTAGAACACACTTTTAGCATAGAGAAAACTGAAGTACCATAGGAGGTTAATTCA CTTCATATAACAGCATAAACTGCCCTTCCTTAAGTAGGAGACAATAGGTACAATAATGCATGCAAATGTT AAGTGGTAAAGCAAACATACAAAGTTTCCCAATAGAAGAGTTTAAATTAAAATCTAAACTTCCAGCCAGG AGCAGTAGTGGACGTCTAGTCCCAGCTACTCAGGAGGCTGAAGCAGGAAGATCACTTGAGCCCAGGAATT CAAGGCCAGCCTGGGTAACATAGGAAGACCCCATCTCTAAAAACATAAAAATAAAAATCTAAGCCTCAAA AGAAAAAAAATAAATAAACAAAAGGCATTTCCTATAAAGTTAAACTGTTACAGAATTGTTTTTCTTAAAC TGCAATAATGAGACTTTAGCACTCTCTTGTCCTCTAAAAGACATTATTTCATGACATGTGCCCATTGGCA GTATTTGAGAATCTAAGAAAGTAGATCACACTAAATATTGATATGCAGACACTAAAATCGTACAACCACT TGGATGACTAGGTTTGAGATATTCCCAAAGTGACAGGTTTTTGTTTTGTTTTGTTTTGTTTTTTGAGACA AGGTCTCGCCCTGTCGCCCAGGCTGGAATGCAGTGGTGCAATCTCAGCTCACTGCAACCTCTGCCTCCTG AGTTCAAGCAATTCTCCTGCCTCAGCCTCCCTGGTAGCTGGGACTGCAGGCATGCACCACCACACCTGGC TAATTTTTGAATTTTTAGTAGAGACAGGGTTTCTCCACGTTAGCCAAGCTGGTCTCGAATTCCTGGCCTC AAGTGCTCTGCCTGCCTCAGCCTCCCAATGCAACCAGCCTTTTTTTTTTTTTTTAACTTTTATTTTAGGT TTGGGGTTACACGTGCAAGTTTGTTATATAGGTAAACTCATGTCAGAGGGGTTTGTTGTACAGCTTATTT TGATAAAATATTAAGTATTAAGCCCAATACCCAATAGTTATCTTTTCTGTTCCTCTCCCTCCTCCCACTC TCCACCCTCAAGTAAACCCCAGTATCTGTGGTTTCCTTCTTTGTGTTCACAAGTCCTTATCATTTAGCTC CCACTTATAAGTGAGAACACGTGGTCTTCGGTTTTCTGTTCCTGCATTACTTTGCTAAGGATAATAGCCT CCAGCTCCATCCATGTTCCTGCAAAAACATGATCTCAGCCGAGCACGGTGGCTCACACGTAATCCCGGCA CTTTGGGAGGCCGAGGTGGGAGGATCATGAGGTCAGGAGTTCAAGAACAGCCTGCCCAACACGGTGAAAC CCCATCTCTACTAGAAATACAAAAATTAGCCAGGCATGGTGGAGGGCACCTGTAATCCCAGCTACTCGGG AGGCTGAGGCAGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAAATCGTGCCACCTGCA TTCCAGCCTGGGCAATAGAGCAAGACTCCATCTCAAAAACAAACAAACAAACAAACAAACAAAAACATGA TCTCGTTGTTTTTTATGGCTGCATAGTATTCCACAGTGTATGTACCACATTTTCTTTATCCAATTTGTCA CTGATGGGCATTTAGGTTGATTCCATGTCTTTGCTATTGTGAATAGTGCTGCAAGTAAATCTCTTTAAAC AGCAAATCTATTACTGCCTGCTTTTCAATGCTTTACCCTCAAGAAACTTGGGCTACAACTCAATAACAAA AAGCAGCATTTTTGTTCTTGTTGTTTTTAATTCAGTTTCTTTTTTTTGTTTTGTTTTGTTTCTAAGAGAC AGGGTCTCACTCTGTGGCCCAGGCTGGAGTGCAGTGGCAGGATCATAGCTCACTATAACCTCGAACTATC AAACTCCTGGGCCTAAGTGATCCTCCCACCTCAGCCTCCTGAGTAGCTAGGACTACAGGTACATGCTGCC AAACCCAGCTAATTAAAAAATATTTTTTTTTTGGTGATGAGGTCTATGTTGCCCAGGCTGGTCTCAAATT CCTGGACTCAAGCGATCCTCCTGCCTCAGCCTCCCAAAACATTGGGATTATACAGATGTAAGTCACTGCA CTTTGGCCATGTGTTGGTTTTTTGTTGTTGTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGACTAGAG TGCGGTGGCGAGATCTCGGTTCACTGTAACCTCCACCTCCTGGTTCAAGCGATTCTCCTGCCTCGCCTCC CGAGTAGCTGGGATTACAGGCACCCACCACCATGCCCAGCTAACTTTAGTATTTTTAGTAGAGATGGGGT TTCGCCATGTTCACCTGGCCTCAAGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTAGGATTATAGGCAT GAGCCACCACACCCAGCCTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCGTCCAGGCTAGAGTACAGT GGCATGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAG TAGCTGGGATTACAGGCGCCTGCCACCACACCTGGCTAATTTTTGTATTTTTAGCAGAGACGGGGTTTCA CCATATTGGCCAGGCTGGTCTCGAATTCCTGACCTCGGGTGATCTGCCCATCTCGGGTGATCTGCCCGCC TCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCATCTTCTCATTTCTTTGGTG AGATTGTTTGGTTTTTGCTTCTGAAGATTTTCCTGTTTTTCTTTTTTTGTTTTTTTTTTTAAGAGACAGA ATCCTGCTCTGTCACCCAGGCTGAAGTGCAGTGGCGCGATCTCAGCTCGCTGCAACCTCCGCCTCCCAAG TTCAAGCATGCACCACCTACAGGTGTGCACCACAACACCCAGCTAATTTTTTTTTTTTTTTTTAGTAGAG GTGGGGTTTCACTACGTATTGGCCAGGCTGGTCTGGAACTCCTGACCTCAGGTGATCCACCCACCTTGGC CTCCCAAAGTTCTGGGATTACAGGCGTGAGCCACCACACCGGGCCTCCCTGTTAAGCCCAGTTTATCCAG TATTTCTAGGTGTTTTGTACAAAAGAGTTTTCAGGGCATTTAGCCTAACATAAAGCAGAAACAAAAGTCA GGATGAGTCAAGTAACAGTATTTGAGAAAACTTCAGAGGTAGAACCAACAGGATTTGCTGATGCTTTGAA TGAAAGCAGAGATAAGACAGAACAGGGAATTTAAGGATGATTCCTAGATTTCTGGCTTGCACAAAGGAGT AGATGGTGGTCTACCATTTATTTAGATGGGGAAGTCAGACAGGGAGAGAGGCACAAACTTGCAGAGAGAA AAGTTTAAGAGTTATATTTTGGGCAAGTAGACAGGAGACAACTACAAGTTACTTGAGGGAAGATGTCAAG TTTGCAGCAGGATGCAGGAGCTGGGAGCCCAGAGCGACTGGGTGGAGGGCCACACTTGCTAGTCATCACA GCGGCTAACACGTCTTCACAGTAAAAGCCAAAACAGGCGGGGCACGGTGGCTCACACCTGTAATCTCAGC ACTTTGGGAGGCTGAGGCAGGCGGATCACCTGAGAACGGGGAGTTCAAGACCAGCCTGACCAACATGGAG AAACCTCGTCTCTAATTAAAAAAAAAAAAAAAATTAGCCAGGCGTAGTGGCGGGCGCCTATAATCCCAGC TACTCAGGAGGCTGTGGCAGGAGAATCGCTTGAACTCAGGAGGCGGAGGTTGCAGTGAGCCGAGATTGTG CCACTGCACTCCAGCCTGGTCAACAGGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAAATTGAGGCC AGGTGCGGTGGCTCATGCCTGTAATCCTAACACTTTGGGAAGCTGAGGCAGGTGGATTACCTGAGCTCAG GAGTTCAAGACCAGCCTGGGTAACACAGTGAAACCCCATCTCTACTAAAATACAAAAAAATTAGCAGAAC ATGGTGGCGTGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAAACTGGGAGG CGGAGGCTGCAGTGAGCCGAGATTGCGCCATTGCACTCCAGCCAGGGCAACAAGAGTGAAACTGTGAAAC TCTGTCTCCAAAAAAAACCAATTTTAATAGGTATACCATTATACACCCATTAAAATGGCTAAAATCCAAA ACACTGACACCACTAAATGCTGGTGAAGATGTGGAGTAACAGGAACTCTCACTCACTGCTGATGGGAATG TATAATGGTACAGTCACTTTGAATATAGTTTGATAGCTTCTTACAAAACTAAACATACTCTTACCATATG ATCTAGCAATTGCACTCCTTGATATTTATCCAGAGGAGGTGAAAAGTCCTGCACTGGAATGTTTATAGCA GCTTTATTCATAACTGCTCAAACTTGGAAGCAACCAAGATGTCTATCCTTCAGGTGAATGTTTGATAAAC AACATGTGGTATATCCATACAATAGAGTATTACTCACCAATGAAAAGAAACAACCTATCAAGCCACAAAA AAACATGAAGAAACCTGAAATGCATATCATTTACTGAAAGAAGCCAATCTGAAAAGGCTACACACTGTAT GTCCAACTATATGACATTCTGGAAAAGACAAAACTATGGAGATATTATAAAAGATCAGTGGTTGCCAGTG GTTCAGCAGAGGAATGAATAGGTGGAGCACAGGGGGTTTCTAGGGCAGTAAAACTATTTTATATAATTGT GTACTGGCAAATATACATCATCACACATTTGTCAAAATCCATAGAATGCTCAACAGAGTGAAATGTAATG TAAACTATGGACTTCAGGCTGGACAGAGTGGCTCACACCTGTAATTCCAACACTTTGGGAGACTGAGGCA GGAGGATTGCTTGAGCCCAGGAGTTTCAGGCTATAGCAAGCTATGATGATGCCACTGCAACCTGGCCTGG ACAACACAGTGAGACCCTACCTCTAAAAAATAATAATAATAAAATAAAAATAGAAATAAAATAAACTCAG GAATTTGGTTAATAATAATGTATCGAGTTGGTTCATTAGTTGTAAGGGACGTACTATACTAATGCAAGAT GTTAATAATAGAAGTTGTGGGAGAAAGTAAGGGGTATATGGAAACTCTCTGTACTTTCCACATAATTTTT CTGTAAAACTAACACTGCTTTAAAAAATAAAGTCTAGACTGGCCGCAGTGGCTCACGCCTGTAATCCCAG CACTTTGGGAGGCCAAGGCAGGCGGATCACGAGGTCAAGAGATCGAGACATCCTGGCTAACATAGTGAAA CCCTGTCTCTATCAAACATACAAAAAATTAGCCAGGCGTGGTGGCAGACAACTATAATCTCAGCTACTTG GGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGCCATTG CACTCCAGCCTGGGCAAAAAGAGTGAAACTCCATCTCAAAAAAAAGAAAAGAAAAGAAAGAAAACACGTA TCTACTAAAATTACAAAAACTAGCCGGGTATGGTGGCAGGCACCTGTAATCCTAGCTACTTAGGAGGCTG AGGCAGGAGAATCACTTGAGCCCGGGAGGTGGAGTTTGCAGTGAGCCAAGATCACACCACTGCACTCAGC CTGGGTGACAGAGCGAGACTCTGCCTCAAAAATAAAATAAAATAAAAATAATAAAGTCTATTAATTTTTA AAATATATTAATTGAGCCGGGCGCGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGG TGGATCACGAGGTCAGGAGATCGAGACCATCCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAA AATTAGCCGGGCATCGTGGCGGGCGCCTGTAGTCCCATCTAGTCAGGAGGCTGAGGCAGGAGAATGGCAT GAACCTGGGAGGCAGAGCTTGCAGTGAGCCGAGATCGCGCCACTACACTCCAGCCTGGGCAACAGAGCGA GACTCCGTCTCAAAAAAAAAAAAAAAAAATTAATTGAGCTTTATGGTTAAGTTTTTAAAAAGATAAATCT GACCCATAAAGTTTAAATAATAGTCAAGATGGAAGATGAGTGATCTCCCCAAGGAGACAAGCTTTTCTAT GAAAATCTTATCAAAATGTATAATGTACTTAGAAAACTAAGTGACCTCATTACACATCATAGTTTTGCAT GATGTAACCACTCTTCAGAGAATATCTCATTTTGTCCTTCAGCTCCCACACAAGAGAAGGTTAAGGAAAT TCCACTACTCATGAAATTATAATCCCACAATGTAAGTGAAGTGGTGGCTGTGCCTAGGAAAGAAAGAGAA TACACGCTTAGAGAGAATCTAGAAAGAAACATTATCCAGTTTGTGTTGGGGATAGCCCATGATCTAAATT CTAAAAAGCACACCCATATAGAACCTAGCCTGGGCTGGGTGCGGTGGCTCATGCCTGTAATCCCAGCACT TTGGGAGACTGAAGCAGGTGGATCACCTGAGGTCAGGAGTTTGAAACCAGTCTGACCAACACAGTGAAAC CCCGTCTCTACTAAAAATACAAAAAAATTAGCCAGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCG GGAGCCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGTGCCATTG CACTCCAGCCTGGGCAATAAGAGTGAAACTCCATCTCAAAAAAAAAAAAAAAAAAGAACCCAGTCTGAAG CATGAATTCACATTGCGTTTTCCAGTCAATCACTCAGCCAAAGAGAACCTGAGGTGGCCAAGATAATGTA ACAACCCTATCAAGTAGGTGTTATTCCCATTTACAGATAAGGACAGAAATGTTAAGTGACTACACATGGA TGCAAACTTGGAATCTTCAAACTCCCAGGCTAGTAGCCAAATTACCTGTTTTTAAATCTCATCTCTGCTA TCTGATCTCTGCCAAGCAAATTTCCCTTTGAATTTGTTATGCAAACAATTAACGAGAATAAAGGAAAATG AGAGCTTTATATACGTTACATGTAATAACTGGAAGTTAACTTTATTAAGACATCTGAAATAAGTCAACAC TTTTAAAACTTAAAGGCTATTCTTTACCAGAATCGTCTGTAGGAATTAACCCCAGCAGTCAGAAAGTACC TTAAAACAAAACCAACATTAATCTGGTAATGTCATGACTTCATAAAATATCCTTAATATTCAGGTACGTG CATACCAAGAAGAGTAAACAGAATAAAAAGAAATCTCTAAAACATTTTCCCTCATTCACTACATGTCTAC TCTTCCACTTACCTTTATCTCTAAAACAAAAACATTTTCTAAACCCTGTGGACATGACTTCACTAATCCA AAGAAGACTTTATATTCTATGGGCCTTGTAAAGCCACATTTCTCAAACTAAGGACCAAGGACCATCTGAA TCAGAATATCTGCTATGCCTGTGAGGATGACCCCAGATAAACTACATCAGACCCTCTCAGGCAGATCCAT AGATTCTTTCTTCTTTTTAAGCAAATAACCCAGGGATTCTTATGTTAAAACCTTTAGACCAACCTTTCTC AAACTCTTCGCTCTCATGGCCCCTTTATTTATTATTTTTTAAATTTAAAAGAAATAATAAGCAAACCGGG TCAGGTGGCTCAAAACTGTAATCCCAGTACTTTGGGAGGCTGAGGCAGGCAGATCTCCTGAGGTTGGGAG TTCGAGACCAGCCTGACCAACATGGAGAAACCCCCATCTCTAATAAAAATACAAAACTAGACGGGTGTGG TGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTTAGGCAAGAGAATCACTTGAATTCGGGAGGCGGA GGTTGTGGTGAGCCGAGATCGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAA AAAAAAAAGAAAAAGAAAGAAAGAAAAGAAATAATAGAGCCGGGCGCAATGGCTCACACCTGTAATCCCA GCACTTTGGGAGGCCAAGGTGGGCATATCATGAGGTCAGGAGTTCAAGATCAGCCTGGCCAACATGGTAA AACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGTGTGGCTGCTAGCCCCTGTAATCCCAGCTACTC GGGAGGCTGAGGCAGGAGAATTGCTGGAACCTGGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCACT GCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAGAGAAAGAATGATTGATAAACC AACTGGGATACTGGCAGATATTTTCTCAAAAATGAAAGAAGGGAAGCTGTCTGTTCAGGGAAAGCAACTG ACAATATTTGTTGCCAATGATAAAATTTGAGCTTTAGAGTAAAAATCAGAATTTGAGAAAGTTTGTATCC ACCACTGTGAGTCTGACAGTTGTCTAATATTAATGATTATTAATGAAACCCCATCTCTACTAAAATTACA AAAATTAGCTGTGCGTGGTGGCACACGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCAC TTGAACCCGGGAGGTGGAGGTTGCAGTGAGCGGAGATCATGCCATTGCACTCCAGCCTGGCAACAGAGCA AGACTCCATCTCAAAAAAAAAAAAAAAAACCGGCCAGGTGCGGTGGCTCACACCTGTAATTCCAGCACTT TGGGAGGCCAAAGCGGGCGGATCACAAGGTCAGGAGATAGAGACCATCCTGGCTAACATGGTGAAACCCC GACTCTACTAAAAATACAAAAAATTAGCCGGGCATTGTGACGGGCGCCTGTAGTCCCAGCTACTTGGGAG GCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCTGAGCTTACAGTGGGCCCAGATCGCACCACTGCACT CCAGCCTGGGCAACAGAATGAGGCTCTGTCTCAAAAAAAAAAAATTGGCGGTTTATGGGTTTGTGGGGGG TACAATTCCTGCCTGTCCAAGTGACAGACTCATTTAATTATCCCCAAGTTAATGTTTAAGTGCAATGGGG TAAAACATGCACTCTGTTAACTAAAAAGCCACATTTCCAAATAGTATACATATTACGATTAAAACATTAA AAATATATGTGTACAGATTTATTCATATAAGCCCAAAAACAAATGTCAGACAATGTTTCTGTCTTTGGAA CCTGACTCAAAATAAGGTTCCTCCTGTTGGCTTCTTCCTGAGACACAGCCAACGCTAATTTGCCGCCCAG GCAAATCATCTATGCCTATCATTAGGAAATCAAATTTATGATATGCATAGCCTAGAATACTACTCTGTAG TTTTTTTGTTTTTGTTTTTGTTTTTTGAGACAGAATCTTGCTCTGTGGCCCAGGCTGGAGTCCAGTGGTG TGATCTCAGGGTTCAAGTGATTCTCCCACCACAGCCTCCCGAGTAGCTGGGATTACAGGCACACACTACC ATGCCTGGCTAATTTTACTATGTAGATTTTTTAAACATGAGGTATATACACATGTATTTGCATTGAGTAT TCTCTAAGATAAAGTGACAAAAAGCAAAATACAGAGTTTGGTGTATTTGCTGCTATATATGGAAGGAACA ACACCCAGAGAATAACATGTTTGCATGCATACATATGAAGTAACTCAGGAGAGATAAATAGTAGGTAACT AGCTGTCCCTGGGAAAGAGTCCCAAGGATAAGGTGCGGACTAACTTTCCACTTACTACATATCTTTTGTA CTGATTCATTTCAAAATTTACTCTAAAATATTGGTATTACAATAAAGAAAACTGGAGTCTAGAACTGAAT GACAAAACTGATACATTCTTACTACAAATCTGTGGTTAAGATTAGCATTAATCTTTCCTAGGCAAAGAGG AAAAAGTTTAACCCAAAGACTGTATGGATCTTCTCTACCCTACATCTCCAATCTCATTCCCATTACTCAG AAAATATTCTCACTGGGTATAGAGGTATGAACTCCCATTGGAAAACTTAGGGTAAACGTCCGTGGAATCT ATGGGGCACTGCTGACCCAGGACACCTGGGATATTTCTGCAGAAACAGGATTTTTTTTTTTTTTTTTTTT GAGATGGAGTCTTGCTCCATAGCCCAGGCTGGAGTGCAATGGCGCGATCTCGGCTCACTGCAACCTCCAC CTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTGAGCCACCGCA CCCAGCCAGATTATTCTTAATCAGTTGATTATTTCTGGCTCCAGAATGCTTCAATTATTCCACCTGCCCC TATGTATAAGCGTTACCACCCTAATTATGCTTGTTTTTGTTTTTTTGGTTGTTTGAGACGGAGTCTCTGT TGCCCAGGCTGGAGTGCAGTGGCACGATCTCGACTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTC TCTTGCTTTAGCCTCCAGAGTAGCTGGGATTACAGGCACGCGTCACCACACCCAGCTAGTTTTTTGTATT TTCAGTAGAAACAGGATTTCACCAAGTCGGCAAGGATGGTCTTGAACTCCTGACCTCAAGCAATCCACAT GCCTTGGTCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCATCGCTCCCGGCCTCCTAATTATGTTTCAT TTTGGTTAATGTTTCAATAAATGTGCTTTCCCTAAACATACTGATGAAAAGAGGCCCAAATGCAAAACTG ATTTGTCGAGAAAGTCAGTCTGAGATGAAATATTTATTATGTCTAAACCACAAGTAGAAAAAAATTCAAA GGCCGACTATTTCAATGCTAACTCAATGCAATATTGCACTTTGTTTGGTTTACGGGAGAGGTAATTTACA CAGCTAACATTTGGGTTTTCAAGATTACATTGTGGGGAGAGAAGGGGAAAACAAGAAAAGTCTAATGCTT TTAGATTCTGTCAGAAAAAGTGTTTGCTAAAAAGCAAAACAAAATGAACATGAGAAAAAATGTGAAAAAA CATGCATTTTAGGAAGCTTTCACCGAAGCAGGTGCTCAAGTTCAGACTCAAATCTTCCAACTCTTGTAAT AAAAATGAGAGGTCAGAATACCACAAACTAATCAAATCAATCAAACAAAGCGGGAAACAGGTGGCTGACA CCAGACTGGGCAGGGTTTTCCTAAATTGGGCTTACCTTCACTAATCCAAATCAGTTTTCAGAAATGGCTT CTACAAAAACTACCCAAACATCCCCCTAATAATTTGCACTCCTCCTCCACAATAGGGAAGCCAAGCCGTT TATTTCCCAGAAGGTTTACTTTCTCTTTCAAGCTCTGCTGGCTTCTTCCTGCCCCGCATACGGCCAGGAA AAAAGAAAAGCACTGCCTTTTCTTTCCTGCCTTCTCTAAAACTGGGGAGATGGGGTGAGAGAACCTGTTT CATGGACAAGCTGGGTGGTTCTTAACTGCAACACTGTTCTGAATACAGATTAGTTTGCAAAGGAAAGTTA CAGGACAGGAAAATAAAGGTCTACCCCTCCAACTAACTCATACACATGTACATTTGCATGTACGCACACA CACAGATGTGAGGGCACATTTAATTCAGCTGAGTAATGTGCAGCAATCAGCTCCCAGCTTCATACCTGGC CACCGGGATGCCTCCTCACTCCCACCTTCTTTACCTGACTCAAAATAAGGTTCCTCCTGTTGGCTTCTTC CTGAGACACAACCAACTCTAATCATTCCTCTTCCCCTCAAACCTTCAACACTACCTGCACTTTCTGGGTC GGGAGCAATTCCTTGGGTGGTAATCCATTTTTAATGTGTTAAATATTACTTAAAATAAGGGAGAGGTAAT CATGGACTGTGGGCAATGCAGAGATTTATCAGAAGGGCATTTGTGTAAACAGGAATTTACAGTTTGCCTT ACCTATTCCTTTTATATGACAGCCTCAATTTCCTCTAACAGAATGTAAGTCCCCCATCCCTATTCATTTA GTTTTTTTCCCATTAGGTTAGAATCTGCTAATTATTCTTTCTCTCCTTTGGGTCATTAGTGGCTGCCATG AATCATAATTTGCCTGACTTTGTAATATCTAACAGATATTACCATTTTAGTTTAGTTTTTGATATGACAG TTTTTTGTTTTTTGTTTTTGTGACGGAGTCTTGCTCTGTCTCCCAGGCTGGAGTGCAGCGGCGCGATCTC AGCTCACTGCAACCCCCACCTCCTGGGTTCAAAAGCAATTCTCCTGCCTCAGCCTCCCGGGTAGCTGGGA CTACAGGCACCCGCCACCACAACAGGCTAAATTTTATATTTTTAGTAGAGACGGGGTCTCACTATGTTGG GCAGGCTGGTCTTGAACTCCTGACCCGCCTCGGCCTCCCAAAGTGCTGGAATTACAGGCGTGAGCCACCA TGCCCGACCTCCTAATTATGTTTTATTCCACCTGCCCCTATGTATAAGCGTTACCACCCTAATTATGCTT TTTGTTTTTCGGTTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGTAGTGCAGTGGCACGATCTC GGTTCACCGCAACCTCCGCCTCCCGGGTTCAAGCGATTATCCTGCCTCAGCCTCCCGAGTAGCTGGGATT ACAGGTGCCCACCACCACAACTGGCTAATTTTTATATTTTTAGTAGAGACGGGGGGGGTCTCACTCTGTT GGGCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTA CAGGCGTGAGCCACCGCACTCGGCCTGATATTATAGTTTTTAATAAGAGTAATTCAGCCTAGGCAACGTG ACGAGATCCTGACTCAAAAAAATTAGAAAATTAGCTGAGGGTGGTAGCACACACCTGTAGCCCCAGCTAC CCCGAAGGCTGAGGCAGGAGGATCACTTGAGCCTAGGAGGTCAAGGCTGTCATGAGCTGTGATCTCACCG CTGCACTCCAGCCTAGGTGACAGAGTGAGAACCTGTCTCAAAAAATAAATAGTAATAATAGTAATTATTA GCACTTGAATGTTACCTGTCTGCCCGGCACTATGCAAAGTACTTGATATGCATCATCTTGCTTCATCCTC TCAATTACTCTACAAGTGGACCTCGTTTCCACAATTGTGGACAGAGAAACTGAAAACCAGAGAAGTGAAA ACAACAGGCCCAAGGTCTAAGAGAAGGCAGAACTGGGATTAAAGCCCAATAGGTCTGACCTGATAGTCCA CTCTTTTAACTGCTATAGTAACTTTGGACCATGAAACCCTCAAACATACCAACCAAGTGTTTCAAAACTA CAATAGCAATCACCTTAGGAATACTCAAAATATAAGTTCTTTGGCTGACGCAGTTAAAAATTCAAAGGTC AGGTAAAATTTCAGTGATGAGCAAGGTCATTTATTCTTATGGCTGGGGGTAGCAGGAAGGAAAGCCGGAT CGTCGAAGCATTATTTTCTTGTAGGGGCAGATTTACCTTCCTTATTATTCTTTTGCTAGGCTGTTAAAAG GAATTTGGAAGGCCAGGCGTGCTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGA TCACAATGTGAGGAGATTGAGACCATCCTGGCTAACACGGTGAAACCCTGTCGCTACTAAAAATATAAAA AAAAAAACATTAGCTGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGA GTGGCGTGAACCCGGGAGGCGGAGCTTGCAATGAGCCAAGATAGCGCCACTGCACTCCAGCCTGGGCGAC AGAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAAGGAATTTGGAATAAATATGTCTCCAAGATAACCTG GTAAACAGAAAGGGCTGCAAAAAATCTGAATAAAAGCAAGTCAATTAACAGGATACATGTAAAACACACA TTTTATATTCCTACAAGTCTTTTTTTTTATAATAGCATGTTATTACTTTTCTAAAAAGGACAAAATAACT TATTTTAATGACATTTAAACCCAATTATTAACAGAAAAGGGATAAGAACTGTGGTTCCTTGGCCTCCTTT CCCCTTGGTTTAGTTCTCCTAAATTAAGAACTTCTACTTATAGCTCCCTGAACACACAAGGCTGTTTTAA GCCTCTGCACCCTCATGTTCCTTCAGCCTTGAATGCAACTTTTTGTAACGCAACTTCGTGGAAAGAATTC CTATTCATCCTATAAAACCCTATTCAGGTGTTCCCATCTGATAAAGCCCCTCAATAATGATGACTTTCTC TCACTCCTGAAAAGAATTAATCTCTTTTCTTGGATATTTAGTAAGAACTTAGATTTACCGAGCTCTTACT ATGTGCCAGGCACTATGCTAAGCATTTTATCCACATTATCTTATTGAATCGTCAACAGTACCTACAAGAT AAGCACTGTTATAATCTTCTTTTACAGATAAGAAAATAGAGGCTCAGATTCTGACTAGGAAGTGGCAGAT CCAGGATTCAGTCCCAGATCTGTTTGACTTCAGAGCCAGAGTCTTGAACCACTCACTGCCCTGTCGTCTC CCCTGTCCTACTTCCATACTGGCATAGCACACACCTCGGTCCCTGCAACATCTCCAGTTTCATGAAAACG GACAATATTTCATTATCCTTGGATCCTGCCTGACGCAATACCTGGCTCTCAACATGTTTGCTGATCTGAA TTAAAGAGTTGCGGTAATCCTTTTTTTTTTCTTTTTTTTTTGAGATGGAGTCCCACTCTGTTGCCCAGGC TGGAGTGCAGTGGCACGATCTCAGCTCACTGCAAGCTCCGCCTCCAGGACTCATGCCATTCTCCTGCCTC AGCCTCCTGAGTAGCTGGGACTACAGGCGTCTGCCACCACGCTGGGCTAATTTTTTGTATTTTTAGTAGA GGCGGAGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACAGCCTCCCA AAGTGCTGGAATTACAGGCATGAGCCACCACACCCGGCTGGGTAAGAGTTGCAGTAATCCTAACATGACA AATGAGAACTGACCATAACAGAAATTCATTCTTCCATATGTTATTCCCAGGCCTCATAACCTCTCCTTCC TCTGAAGACATGTAGCATTCAGTGTAGCACTGTCAGAATGTCTCACTCTGTCCCCCAGTCTGGAGTGCAG TGGCAGGATCTTGGCTCACTGCAGCCTCCACCTCCCAGGTTCAAGCAATTCTCCTGGCTCAGCCTCCAGA GTAGCTGGAACTACAGGCGTGTGCCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTT ACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCCGCTCACCTCTGCCTCACAAAGCGC TGGGATTACAGGCATCAGCCACCATGCCCAGCCTGTTTTTGCCTTTTTTTTTTTTTTAAAGAAACAAAGT GGTCTCACTATGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTCAAGCAATCCTCTTGCCTCGGCCTTCCA AAGTGCTGGGATTATAGGCATGAGCCACTGCTCCTGGCCCGATATGCTACTCCTTTTAAAAACTGGAGGC ATCTCAAACAATTTACCACCAAAGGACCATGTGGCCATACTGACTAAAGCGCACTACACTTTACGCTTAC GTCTTGTAAGCCAAGGTGTCTAACAAAGAGTATATAACCACCATATTAATTCTTTACACCATAATCAATA AGGGCTGGGCCAGCCCAGCAATGCCATCCTCCTGGATCTCACTGAGGCTGCTCCAGAACACCAGAAGTTC TTCAGGATTCGGGGATGTCCCTCAAGTACTCTTTCAGTGGTTTTTATAAATGACTCAAAAGTTATGGTGA AATTTTTAAGTGCCAAAGACATAAAATATGAGTGGTGGTTTGTATCCAATCAAAAATCCTCAAAAAACAC TTCTGCACTTAAGCACACTATACTTTTTTCACCCAAAGTACCAAATCAAACTAGTCAGGATACCTACCTT TGTACAATGTCAGACTCCAGTTAATAACTCCCCTAGGGCAGAGGGCATATGCACTGATTTACTTTGTACA AATTAACCAGCATCAGGCAATCAGGCCTGTGCCTAACACATAGTAAGCACTCTATGATTAAACATCAGTG CTTCGGCTCCAAAGTTTTATTTATTTATTTATTTATTTATTTTTTTTTTTTTTGAGACGGAGTCTCGCTC TGTCGCCCAGGCTGGAGTGCAGTGGTGCGATATCGGCTCACTGCAAGCTCCGCCTCCCGAGTTCACGCTC TTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGACGCCCGCCACAACGCCCGGCTACTTTTTTTT GTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGGCCTCGTGATCCG CGCGTCTGGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCGCCCCGAAAGTTTTA AAAGCTTCCCCTACAAAAGAACAGAACTGAAATTCCTTGGTCCTGTATTCAATGTCTTTTGTAAGTAATC ACTTCTCCCCTACTTACCCTCCTAGTCTACCGGGCTACCAGGAATTTTTTTTTTTTTTGGAGACAGGGTC TCACTCTGTCACCCAGGCTGGAGTGCGGTGGCGGGATCACGGCTCACTGCAGCCTTAACCCCCGGGGCTT GGGTGATCCTCCCACCTTAGTCTCACCAGTAGCTGGGACTACAGGTCCACGCCACCAGGCCTGGCTAATT TTTTTTATTTTTAGGGGAGAGGGAGTTTTACCACGTTGCCCAAGCTGGTCTCAAACTCCTGGGCTCAAGC AATCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATAAACCACCGCAAATTCTTTACACCTA TCAAATTCCACCCATTATTTGGGACCCAGTTGAAATCCCTCTTTGGCAAAAAGACTTTCTAGACAACTCC AGGCCTCATAACCTCTCCTTTCTCTGAAGATCTGTAGCATTCAGCCTAGCACTGTCCAATAGAACGTTCT ATGATAACAGAAAAGTTCTACATCTGTACTGTATGTTCTTTTATGTAGAACAGCTACCTTGTTAGCACAA GTGTAAAGTCTCACCATCTCTTTGATGACAACATGTTACATTGGATGGTTAAAACATTTATCAGCTCCCC CAGTAGACTGCAATTTCTGTGAACAAGATACAACTTATTCTTCATAGCAACTCTGACAAAGTTGCAAAAG GTATATATATGTTGGCCAGGCAAGGTGGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGC AGATCTCTTGAGGTCAGGAGTTTGAGACCAGCCTGGTCAATATAGTGAAACCTTATCTCTACTAAAAATA CAAAAATTAGCCGGGCGTAGTGGCGGGCACCTGTAATCCCAGCTACTCAGGAGGCTGAGGTGCGAGAATC ACTTGAACCCGGGAGGAGGAGGTTGCAGTGAGCCACGATCATGCCACTGCACTCCAGCCTGGGTGATAGA GTGCAACTCCAACTCAAAAAAAAAAAAAAAAAAGTATATATTTGTTGATTTGCACATCACCTAAGAAAAC CATAAGCTAAGAAGGTTTGGACTCAGGCGTCTGGAAAGTTGGTCACCACCTCTACCCCACCTCATATCTG AATGTCAAGAGACACGTAGAGGCAGAGAAGTTAAAGCAACTTTCTAGAGACAGAAATGACCACTGATCAA GCCACAATGCACTCTGGTTTAAATGACATTTAGGTCATGACTGTCCTTAATCTAAAACAAACCTAGATTA GTATTTCTTTTCATTAGTAAATAGCTAAATTCTGATGGTAAATTATGCTGACCAAAAACAGTTCCTCACT TCCCAAGTTAGACATAGCAATTAGAAAAATAATCTAAGCAAGCTCCATTTGTATTTCTTTTTTCACCTGT TTATTGAATATTTACCTCCCATGAAGTCTTTCAGCCTATTGGTGGTATTTTACTGTTCAGATATATGTTA GAATTTCACTGATACTTACTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGATAGAGGTG GGCAAATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAATATGGTAAAACCCCGGTCTCTACTAAAAA TACAAAAATTAGCTGGGCGTGGTGGCGCACGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAA TCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCGCCACTGCACTCTAGCCTGGGCAACA GAGCAAGACTCTGACTCAAAAAAAAAAAAAAAAAGAATTTCACTGATACTTTTCACAAAATATACAGAAG GAGGCACAAATTCCACCACTATGGCACTCTGCTGCGTTGGCCAAGTGTCTTGATCCTTTGGCCTCAATTT TCTTATCTACGATATTAGGGTAATTGTTATGTGAACTACCCACCTCACAAGTCCTTTGTGGGTTAATTCA TAACTGTGCTGTGGGTATTTCTTTTTCTTTCCTTTCTTCCTCCTTTCCTTTCTTTCTTTCTTAAAGATGG GTTCTCATTATGGTGCTTAGACTAGACTCTAGACCCAATTCCTGGCCTCTCACCATGTTGCCCAGACCAG ACTCAACTCCTGGACTCAAGGAATCCTCCCACCTCAGCCTTCAATTAGCTGGGATCAGAGGTGTGCACCA CCATGCCTGGCACTGTGGATATTTCTAAGTGATTATTCTTCTCAAATGAACTACATAAAAAACAAAAGAT TCATGAATTTACTAATGGTTCTTTGTGATGGATGTGCTAATATAGAGACTAAAATCAAGGCTCCAACCTC TAAAACATTTTTTTTTAAATTCCAGACTTGTTTCCCCATCCCACTGTGCAAACTGAACAAAAACTGGGCT AGCACTCCTGTCTGGAACATGTAATAAGGAAATAAATGTGCTGACTCAGAGAACACAGACATATTTAATA TAAAATAAGATAGAAAACTGGCTGAACCAAGTCATAACACAGTCTAAATCCACATATAAAAGATTGAGAT GATTTTCTGCTTTGCTTTATTCAAGCCCAATGCTTTATCAGCACAGCCAGCCAAAAATTTACAACCCATA CACAGACTATGTAAACCTTTAGTTGCACATACAGTAAGACCAGCAGGTACACACTATACACATTTTTAAT TAAAAAAATGACTAACCACTGATTTTGTCACCACACTTAACAACGACCTGATATGGCACAGAGTGATGTG TACCAAACATGGAAATACCAACTTGGGCGACGGTTTGAATCTTGTTAACTTCAGTGCAACCACACCCCCC AAATGCATGTAAAGTTTGCACACATGGTTTTTTCAAGGCCAGCCTGTCTTTGTTTCCCTCTCCTCTGCAT TTACCCAAGATCTTGGCTCTGAGACAGAAAACTCCCACTCTCAATTGGTTCATTCCGTCCTATGCAATTA AGCAACACCACAATCCAGTAAATGCAATGGCTCAATTATTTATCTTCTGGCCGACTTTACCAGGTATTTG GAAAAGGACAATGTCAAGAGGTTTATTTCTCTCTCTAGAGCTGGCTTGACGGGTTGATGGGGATTTTATT TTGTCTTTTTTTCTCTTTTTTACAAGGCGGGGACGTGGGGGGAGCATAATTTAACCTAGAAAAAGATGCG AGGGAATTTAGAAAGAGTACCGGTCTGTCAATTTCCCTACAGGAAACTTGATTCTTATGCAATAAAGCCT ACCCACGACCAGCCAGCCCGTAAGGCTGCAGGCGACAGACACACCTATTCCTGCCTCCAAAAGGGCACAG CTGTCTCCTGAAGGAGCGGGAACAGGGCAAGCGGAGGAAGTGGCTCAGCGGGAGCCGCCGACCGGGCGGG GAGGAGGCGCTTTCCGACCCCCCACTCGCGCCGGTGATCCCCGTCGGCGTGACAGTCGCTCCGGTGGCCG GAACGTCCCCAGGGCCCCAGGGAGCAGGAAATCGGGGGACTGTCCCTCACTCCTGCCGCCGCAACCGAGT GCGCCCTCGCCCCACGGTGCCCCCTCGAGCGCGTTCTGTTTCTCCGAAGAACGAAACTTCCCTCCAGCGC CCCGAGTCCCTTCCGAGGCCCGCTCCTGTCATCCCGAAGAGTCTTCCCTCAGGGCGACCCTCCGCGTCTC TTCATCTCTCCCGGCCCCACTGCAGCGTCCATCACAACATCCCCAAGGTCCCAGAGGCCCCCTGCCGCTG CGGAGCCCCCGGGTCCCCAGGCCTCCCCAACGGCCCCACCCTGCACCCCCTTCACCTGTTTCTCCGGCAG AGGCCGAGAGGCCGGGGCTGCGCGTGTGCCGGGGACGGGCGGCGAGGCTCCCTCAGGCCGAAGGGCCTCT CCGAGCCGAGGGGGAGAGACAGCGCCAAGCCGGGGTGCCTGTCCAGGATCCGGTTGGGGCTTGTTCCCTC GGCTGCGAC
Protein Name	STAT3_HUMAN
Length	770
Moltype	AA
Topology	linear
Division	PRI
Update Date	12-OCT-2022
Create Date	01-FEB-1995
Definition	RecName: Full=Signal transducer and activator of transcription 3; AltName: Full=Acute-phase response factor
Primary Accession	P40763
Accession Version	P40763.2
Other SeqIDs	sp\|P40763.2\|STAT3_HUMAN,gi\|48429227
Organism	Homo sapiens
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Comment	On or before Mar 15, 2005 this sequence version replaced gi:2135013, gi:728870.; [FUNCTION] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:22306293, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). {ECO:0000250\|UniProtKB:P42227, ECO:0000269\|PubMed:10688651, ECO:0000269\|PubMed:12359225, ECO:0000269\|PubMed:12873986, ECO:0000269\|PubMed:15194700, ECO:0000269\|PubMed:17344214, ECO:0000269\|PubMed:18242580, ECO:0000269\|PubMed:22306293, ECO:0000269\|PubMed:23084476, ECO:0000269\|PubMed:28065600}.; [SUBUNIT] Forms a homodimer or a heterodimer with a related family member (at least STAT1) (PubMed:28065600). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1 (PubMed:15994929, PubMed:15194700, PubMed:17344214, PubMed:15677474, PubMed:15467733) (By similarity). Interacts with IL23R in presence of IL23 (PubMed:12023369). Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2 (PubMed:18234692). Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear (PubMed:17956865). Interacts with BMX (PubMed:10688651). Interacts with ZIPK/DAPK3 (PubMed:16219639). Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3 (PubMed:9388184). In prostate cancer cells, interacts with PRKCE and promotes DNA binding activity of STAT3 (PubMed:17875724). Interacts with STMN3, antagonizing its microtubule-destabilizing activity (By similarity). Interacts with the 'Lys-129' acetylated form of BIRC5/survivin (PubMed:20826784). Interacts with FER (PubMed:19147545). Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain) (PubMed:23084476). Interacts with INPP5F; the interaction is independent of STAT3 Tyr-705 phosphorylation status (PubMed:25476455). Interacts with FGFR4 (PubMed:26675719). Interacts with OCAD1 (By similarity). Interacts (unphosphorylated or phosphorylated at Ser-727) with PHB1 (PubMed:31899195). Interacts and may form heterodimers with NHLH1 (By similarity). {ECO:0000250\|UniProtKB:P42227, ECO:0000250\|UniProtKB:P52631, ECO:0000269\|PubMed:10688651, ECO:0000269\|PubMed:11773079, ECO:0000269\|PubMed:12023369, ECO:0000269\|PubMed:12873986, ECO:0000269\|PubMed:15194700, ECO:0000269\|PubMed:15467733, ECO:0000269\|PubMed:15677474, ECO:0000269\|PubMed:15994929, ECO:0000269\|PubMed:16219639, ECO:0000269\|PubMed:17344214, ECO:0000269\|PubMed:17875724, ECO:0000269\|PubMed:17956865, ECO:0000269\|PubMed:18070987, ECO:0000269\|PubMed:18234692, ECO:0000269\|PubMed:19147545, ECO:0000269\|PubMed:20826784, ECO:0000269\|PubMed:23084476, ECO:0000269\|PubMed:25476455, ECO:0000269\|PubMed:26675719, ECO:0000269\|PubMed:28065600, ECO:0000269\|PubMed:31899195, ECO:0000269\|PubMed:9388184}.; [SUBUNIT] (Microbial infection) Interacts with HCV core protein. {ECO:0000269\|PubMed:12208879}.; [SUBUNIT] (Microbial infection) Interacts with S.typhimurium SarA. {ECO:0000269\|PubMed:29924996}.; [SUBUNIT] (Microbial infection) Interacts with human cytomegalovirus (HHV-5) immediate early protein IE1; this interaction leads to STAT3 nuclear accumulation and disruption of IL6-induced STAT3 phosphorylation. {ECO:0000269\|PubMed:27387064}.; [INTERACTION] P40763; O14874: BCKDK; NbExp=2; IntAct=EBI-518675, EBI-1046765; P40763; Q96G01: BICD1; NbExp=2; IntAct=EBI-518675, EBI-1104509; P40763; P51451: BLK; NbExp=9; IntAct=EBI-518675, EBI-2105445; P40763; P51813: BMX; NbExp=8; IntAct=EBI-518675, EBI-696657; P40763; P07384: CAPN1; NbExp=2; IntAct=EBI-518675, EBI-1542113; P40763; P50750: CDK9; NbExp=2; IntAct=EBI-518675, EBI-1383449; P40763; P31146: CORO1A; NbExp=2; IntAct=EBI-518675, EBI-1046676; P40763; Q99062: CSF3R; NbExp=4; IntAct=EBI-518675, EBI-7331284; P40763; Q9UER7: DAXX; NbExp=4; IntAct=EBI-518675, EBI-77321; P40763; O95661: DIRAS3; NbExp=3; IntAct=EBI-518675, EBI-6139214; P40763; Q13011: ECH1; NbExp=2; IntAct=EBI-518675, EBI-711968; P40763; P30084: ECHS1; NbExp=3; IntAct=EBI-518675, EBI-719602; P40763; P00533: EGFR; NbExp=15; IntAct=EBI-518675, EBI-297353; P40763; P04626: ERBB2; NbExp=9; IntAct=EBI-518675, EBI-641062; P40763; Q15910: EZH2; NbExp=5; IntAct=EBI-518675, EBI-530054; P40763; Q8TAE8: GADD45GIP1; NbExp=4; IntAct=EBI-518675, EBI-372506; P40763; Q9BVP2: GNL3; NbExp=2; IntAct=EBI-518675, EBI-641642; P40763; P12268: IMPDH2; NbExp=3; IntAct=EBI-518675, EBI-353389; P40763; P23458: JAK1; NbExp=2; IntAct=EBI-518675, EBI-1383438; P40763; Q07666: KHDRBS1; NbExp=2; IntAct=EBI-518675, EBI-1364; P40763; P25791: LMO2; NbExp=3; IntAct=EBI-518675, EBI-739696; P40763; O43318: MAP3K7; NbExp=4; IntAct=EBI-518675, EBI-358684; P40763; O15264: MAPK13; NbExp=2; IntAct=EBI-518675, EBI-2116951; P40763; P45984: MAPK9; NbExp=2; IntAct=EBI-518675, EBI-713568; P40763; P45984-1: MAPK9; NbExp=3; IntAct=EBI-518675, EBI-713586; P40763; Q8TE76: MORC4; NbExp=2; IntAct=EBI-518675, EBI-3940432; P40763; Q92665: MRPS31; NbExp=2; IntAct=EBI-518675, EBI-720602; P40763; Q16236: NFE2L2; NbExp=5; IntAct=EBI-518675, EBI-2007911; P40763; Q14938-3: NFIX; NbExp=3; IntAct=EBI-518675, EBI-20559045; P40763; Q14938-4: NFIX; NbExp=3; IntAct=EBI-518675, EBI-20558886; P40763; P22736: NR4A1; NbExp=3; IntAct=EBI-518675, EBI-721550; P40763; Q9ULD0: OGDHL; NbExp=2; IntAct=EBI-518675, EBI-3940481; P40763; P06401: PGR; NbExp=3; IntAct=EBI-518675, EBI-78539; P40763; Q96HA1-2: POM121; NbExp=3; IntAct=EBI-518675, EBI-11956563; P40763; P32119: PRDX2; NbExp=4; IntAct=EBI-518675, EBI-1266300; P40763; P18031: PTPN1; NbExp=2; IntAct=EBI-518675, EBI-968788; P40763; Q04206: RELA; NbExp=4; IntAct=EBI-518675, EBI-73886; P40763; P07949: RET; NbExp=3; IntAct=EBI-518675, EBI-2480756; P40763; O75116: ROCK2; NbExp=3; IntAct=EBI-518675, EBI-366288; P40763; P46781: RPS9; NbExp=2; IntAct=EBI-518675, EBI-351206; P40763; O00570: SOX1; NbExp=2; IntAct=EBI-518675, EBI-2935583; P40763; P08047: SP1; NbExp=4; IntAct=EBI-518675, EBI-298336; P40763; P30626: SRI; NbExp=3; IntAct=EBI-518675, EBI-750459; P40763; P42224: STAT1; NbExp=8; IntAct=EBI-518675, EBI-1057697; P40763; P40763: STAT3; NbExp=8; IntAct=EBI-518675, EBI-518675; P40763; Q06520: SULT2A1; NbExp=2; IntAct=EBI-518675, EBI-3921363; P40763; P43405: SYK; NbExp=10; IntAct=EBI-518675, EBI-78302; P40763; Q810M5: Zdhhc19; Xeno; NbExp=4; IntAct=EBI-518675, EBI-22225085; P40763; Q9DUM3; Xeno; NbExp=4; IntAct=EBI-518675, EBI-7971837; P40763-2; P05067: APP; NbExp=3; IntAct=EBI-10692009, EBI-77613.; [SUBCELLULAR LOCATION] Cytoplasm {ECO:0000269\|PubMed:28065600, ECO:0000269\|PubMed:31899195}. Nucleus {ECO:0000269\|PubMed:28065600, ECO:0000269\|PubMed:31899195}. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P40763-1; Sequence=Displayed; Name=Del-701; IsoId=P40763-2; Sequence=VSP_010474; Name=3; IsoId=P40763-3; Sequence=VSP_055918, VSP_055919.; [TISSUE SPECIFICITY] Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4(+) T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195). {ECO:0000269\|PubMed:31899195}.; [PTM] Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha, LEP and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphorylation at Tyr-705 by PTK6, isoform M2 of PKM (PKM2) or FER leads to an increase of its transcriptional activity (PubMed:12763138, PubMed:16568091, PubMed:21135090, PubMed:22306293). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling. {ECO:0000250\|UniProtKB:P42227, ECO:0000269\|PubMed:10688651, ECO:0000269\|PubMed:12359225, ECO:0000269\|PubMed:12763138, ECO:0000269\|PubMed:15465816, ECO:0000269\|PubMed:16219639, ECO:0000269\|PubMed:16568091, ECO:0000269\|PubMed:17344214, ECO:0000269\|PubMed:17875724, ECO:0000269\|PubMed:18234692, ECO:0000269\|PubMed:18599021, ECO:0000269\|PubMed:19147545, ECO:0000269\|PubMed:21135090, ECO:0000269\|PubMed:22306293, ECO:0000269\|PubMed:7701321}.; [PTM] Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). {ECO:0000269\|PubMed:28065600}.; [PTM] Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). {ECO:0000269\|PubMed:28065600}.; [PTM] (Microbial infection) Phosphorylated on Tyr-705 in the presence of S.typhimurium SarA. {ECO:0000269\|PubMed:29924996}.; [DISEASE] Hyper-IgE recurrent infection syndrome 1, autosomal dominant (HIES1) [MIM:147060]: A rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures. {ECO:0000269\|PubMed:17676033, ECO:0000269\|PubMed:17881745, ECO:0000269\|PubMed:23342295, ECO:0000269\|PubMed:26293184}. Note=The disease is caused by variants affecting the gene represented in this entry.; [DISEASE] Autoimmune disease, multisystem, infantile-onset, 1 (ADMIO1) [MIM:615952]: A disorder characterized by early childhood onset of a spectrum of autoimmune manifestations affecting multiple organs, including insulin-dependent diabetes mellitus and autoimmune enteropathy or celiac disease. Other features include short stature, non-specific dermatitis, hypothyroidism, autoimmune arthritis, and delayed puberty. {ECO:0000269\|PubMed:25038750, ECO:0000269\|PubMed:28073828}. Note=The disease is caused by variants affecting the gene represented in this entry.; [MISCELLANEOUS] Involved in the gp130-mediated signaling pathway.; [SIMILARITY] Belongs to the transcription factor STAT family. {ECO:0000305}.; [CAUTION] Was shown to be S-palmitoylated by ZDHHC19, leading to STAT3 homodimerization. However, this study was later retracted. {ECO:0000305\|PubMed:31462771, ECO:0000305\|PubMed:32555452}.; [WEB RESOURCE] Name=Wikipedia; Note=STAT3 entry; URL='https://en.wikipedia.org/wiki/STAT3'.; [WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL='http://atlasgeneticsoncology.org/Genes/STAT3ID444.html'.; [WEB RESOURCE] Name=STAT3base; Note=STAT3 mutation db; URL='http://structure.bmc.lu.se/idbase/STAT3base/'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/stat3/'.
Source Db	UniProtKB: locus STAT3_HUMAN, accession P40763;; class: standard.; extra accessions:A8K7B8,K7ENL3,O14916,Q9BW54; created: Feb 1, 1995.; sequence updated: Jun 7, 2004.; annotation updated: Oct 12, 2022.; xrefs: L29277.1, AAA58374.1, AJ012463.1, CAA10032.1, JB252046.1, AK291933.1, BAF84622.1, AY572796.1, AAS66986.1, AC087691.9, CH471152.1, EAW60822.1, BC000627.2, AAH00627.1, BC014482.1, AAH14482.1, AF029311.1, AAB84254.1, A54444, NP_003141.2, NP_644805.1, NP_998827.1, XP_005257673.2, XP_005257674.2, XP_011523447.1, XP_011523448.1, XP_016880461.1, XP_016880464.1, 5AX3_B, 5U5S_B, 6NJS_A, 6NUQ_A, 6QHD_A, 6QHD_B, 6TLC_A, 6TLC_B; xrefs (non-sequence databases): CCDS:CCDS32656.1, CCDS:CCDS32657.1, CCDS:CCDS59288.1, PDBsum:5AX3, PDBsum:5U5S, PDBsum:6NJS, PDBsum:6NUQ, PDBsum:6QHD, PDBsum:6TLC, AlphaFoldDB:P40763, SMR:P40763, BioGRID:112651, ComplexPortal:CPX-6041, ComplexPortal:CPX-6043, ComplexPortal:CPX-6044, ComplexPortal:CPX-6046, ComplexPortal:CPX-6049, CORUM:P40763, DIP:DIP-33584N, ELM:P40763, IntAct:P40763, MINT:P40763, STRING:9606.ENSP00000264657, BindingDB:P40763, ChEMBL:CHEMBL4026, DrugBank:DB05959, DrugBank:DB16630, DrugCentral:P40763, GuidetoPHARMACOLOGY:2994, MoonDB:P40763, GlyGen:P40763, iPTMnet:P40763, MetOSite:P40763, PhosphoSitePlus:P40763, SwissPalm:P40763, BioMuta:STAT3, DMDM:48429227, CPTAC:CPTAC-1275, CPTAC:CPTAC-1276, CPTAC:CPTAC-1751, EPD:P40763, jPOST:P40763, MassIVE:P40763, MaxQB:P40763, PaxDb:P40763, PeptideAtlas:P40763, PRIDE:P40763, ProteomicsDB:55378, ProteomicsDB:55379, ABCD:P40763, Antibodypedia:660, CPTC:P40763, DNASU:6774, Ensembl:ENST00000264657.10, Ensembl:ENSP00000264657.4, Ensembl:ENSG00000168610.16, Ensembl:ENST00000404395.3, Ensembl:ENSP00000384943.3, Ensembl:ENST00000585517.5, Ensembl:ENSP00000467000.1, Ensembl:ENST00000588969.5, Ensembl:ENSP00000467985.1, Ensembl:ENST00000677030.1, Ensembl:ENSP00000503662.1, Ensembl:ENST00000677723.1, Ensembl:ENSP00000503574.1, Ensembl:ENST00000678044.1, Ensembl:ENSP00000503102.1, Ensembl:ENST00000678827.1, Ensembl:ENSP00000503634.1, Ensembl:ENST00000678906.1, Ensembl:ENSP00000504184.1, Ensembl:ENST00000678960.1, Ensembl:ENSP00000503181.1, Ensembl:ENST00000679014.1, Ensembl:ENSP00000503237.1, GeneID:6774, KEGG:hsa:6774, MANE-Select:ENST00000264657.10, UCSC:uc002hzl.2, CTD:6774, DisGeNET:6774, GeneCards:STAT3, GeneReviews:STAT3, HGNC:11364, HPA:ENSG00000168610, MalaCards:STAT3, MIM:102582, MIM:147060, MIM:615952, neXtProt:NX_P40763, OpenTargets:ENSG00000168610, Orphanet:520, Orphanet:2314, Orphanet:512017, Orphanet:99885, Orphanet:438159, Orphanet:86872, PharmGKB:PA337, VEuPathDB:HostDB:ENSG00000168610, eggNOG:KOG3667, GeneTree:ENSGT01050000244905, HOGENOM:CLU_014189_3_0_1, InParanoid:P40763, OrthoDB:327469at2759, PhylomeDB:P40763, TreeFam:TF318648, PathwayCommons:P40763, Reactome:R-HSA-1059683, Reactome:R-HSA-111453, Reactome:R-HSA-1266695, Reactome:R-HSA-1433557, Reactome:R-HSA-1839117, Reactome:R-HSA-186763, Reactome:R-HSA-198745, Reactome:R-HSA-201556, Reactome:R-HSA-2559582, Reactome:R-HSA-2586552, Reactome:R-HSA-2892247, Reactome:R-HSA-390471, Reactome:R-HSA-452723, Reactome:R-HSA-6783783, Reactome:R-HSA-6785807, Reactome:R-HSA-8849474, Reactome:R-HSA-8854691, Reactome:R-HSA-8875791, Reactome:R-HSA-8983432, Reactome:R-HSA-8984722, Reactome:R-HSA-8985947, Reactome:R-HSA-9008059, Reactome:R-HSA-9020933, Reactome:R-HSA-9020956, Reactome:R-HSA-9020958, Reactome:R-HSA-9616222, Reactome:R-HSA-9670439, Reactome:R-HSA-9673767, Reactome:R-HSA-9673770, Reactome:R-HSA-9674555, Reactome:R-HSA-9701898, Reactome:R-HSA-9705462, Reactome:R-HSA-9707564, Reactome:R-HSA-9725370, Reactome:R-HSA-9725371, Reactome:R-HSA-982772, SignaLink:P40763, SIGNOR:P40763, BioGRID-ORCS:6774, ChiTaRS:STAT3, GeneWiki:STAT3, GenomeRNAi:6774, Pharos:P40763, PRO:PR:P40763, Proteomes:UP000005640, RNAct:P40763, Bgee:ENSG00000168610, ExpressionAtlas:P40763, Genevisible:P40763, GO:0000785, GO:0005737, GO:0005829, GO:0005654, GO:0005634, GO:0005886, GO:0090575, GO:0005667, GO:0031490, GO:0003677, GO:0001228, GO:0003700, GO:0000981, GO:0140297, GO:0042802, GO:0004879, GO:0070878, GO:0046983, GO:0042803, GO:0019901, GO:0019903, GO:0000978, GO:0061629, GO:0035591, GO:0005102, GO:0000976, GO:0048708, GO:0008283, GO:0032870, GO:0097398, GO:0044320, GO:0019221, GO:0006952, GO:0042755, GO:0097009, GO:0001754, GO:0042593, GO:0060396, GO:0060397, GO:0006954, GO:0070102, GO:0030522, GO:0033210, GO:0042789, GO:0010507, GO:0008285, GO:0010629, GO:0045820, GO:2001223, GO:2000635, GO:2000737, GO:0000122, GO:0007399, GO:0016310, GO:0045766, GO:0030335, GO:1900017, GO:0045893, GO:0045648, GO:0010628, GO:0032731, GO:0032733, GO:0032755, GO:0032757, GO:1904685, GO:1902895, GO:2000637, GO:0051092, GO:0045747, GO:0045944, GO:0032760, GO:1905564, GO:0006606, GO:0060019, GO:0007259, GO:0051726, GO:0042127, GO:0006355, GO:0060259, GO:0040014, GO:0006357, GO:0032355, GO:0044321, GO:0043434, GO:0060221, GO:0019953, GO:0007165, GO:0035019, GO:0072540, GO:0072538, GO:0001659, GO:0007179, CDD:cd10374, Gene3D:1.10.532.10, Gene3D:2.60.40.630, Gene3D:3.30.505.10, InterPro:IPR008967, InterPro:IPR000980, InterPro:IPR036860, InterPro:IPR001217, InterPro:IPR035855, InterPro:IPR036535, InterPro:IPR013800, InterPro:IPR015988, InterPro:IPR013801, InterPro:IPR012345, InterPro:IPR013799, PANTHER:PTHR11801, Pfam:PF00017, Pfam:PF01017, Pfam:PF02864, Pfam:PF02865, SMART:SM00964, SUPFAM:SSF47655, SUPFAM:SSF48092, SUPFAM:SSF49417, SUPFAM:SSF55550, PROSITE:PS50001
Sequence	maqwnqlqqldtryleqlhqlysdsfpmelrqflapwiesqdwayaaskeshatlvfhnllgeidqqysrflqesnvlyqhnlrrikqflqsrylekpmeiarivarclweesrllqtaataaqqggqanhptaavvtekqqmleqhlqdvrkrvqdleqkmkvvenlqddfdfnyktlksqgdmqdlngnnqsvtrqkmqqleqmltaldqmrrsivselagllsameyvqktltdeeladwkrrqqiaciggppnicldrlenwitslaesqlqtrqqikkleelqqkvsykgdpivqhrpmleerivelfrnlmksafvverqpcmpmhpdrplviktgvqfttkvrllvkfpelnyqlkikvcidkdsgdvaalrgsrkfnilgtntkvmnmeesnngslsaefkhltlreqrcgnggrancdaslivteelhlitfetevyhqglkidlethslpvvvisnicqmpnawasilwynmltnnpknvnfftkppigtwdqvaevlswqfssttkrglsieqlttlaekllgpgvnysgcqitwakfckenmagkgfsfwvwldniidlvkkyilalwnegyimgfiskererailstkppgtfllrfsesskeggvtftwvekdisgktqiqsvepytkqqlnnmsfaeiimgykimdatnilvsplvylypdipkeeafgkycrpesqehpeadpgsaapylktkficvtpttcsntidlpmsprtldslmqfgnngegaepsaggqfesltfdmeltsecatspm