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| Record Information |
| Record ID |
139 |
| Pubmed ID |
34526360 |
| SNP |
|
| Gene ID |
8651 |
| Protein ID |
O15524 |
| Vaccine Adverse Events |
transient lymphopenia, injection site reaction, fatigue, flu-like symptoms temporally related to vaccination, and arthralgia and decreased lymphocyte count, asymptomatic transient elevations in autoimmune serologies |
| Vaccine |
IGFBP-4 N-terminus plasmid-based vaccine |
| Gene Name |
SOCS1 |
| Official Symbol |
suppressor of cytokine signaling 1 [Homo sapiens (human)] |
| Aliases |
AISIMD, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP-3, TIP3 |
| Other Designations |
suppressor of cytokine signaling 1; JAK binding protein; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Tec-interacting protein 3; cytokine-inducible SH2 protein 1 |
| Chromosome |
16 |
| Location |
16p13.13 |
| Annotation |
Chromosome 16 NC_000016.10 (11254417..11256204, complement) |
| MIM |
603597 |
| DNA Sequence |
>NC_000016.10:11254417-11256204 Homo sapiens chromosome 16, GRCh38.p14 Primary Assembly
AAAAAAAAAACTTTCATAATAAAGTTTATTACCTAAACTGACTTTAAAAAATATAAAATAGGATTCTGCA
CAGCAGAAAAATAAAGCCAGAGACCCTCCCCCAACCCCTGGTTTGTGCAAAGATACTGGGTATATGTAAA
CATGAAGAGGTAGGAGGTGCGAGTTCAGGTCCTGGCTCCAGATACAGTTAAGCTGCTACAACAACCAGGG
GGACCCAGAGGGAGCACCAGGAGGGGGAGGACCCCCTCAAGAGGTGAGAAGGGGTCTGCGGCCTCGTCTC
CAGCCGAGGGCGGGAGGCGCCTCGCCCCTACACCCATCCGCTCCCTCCAACCCAGGCCGGGGAGGGTACC
CACATGGTTCCAGGCAAGTAATAACAAAATAACACGGCATCCCAGTTAATGCTGCGTGCACGGCGGGCGC
TGCCGGTCAAATCTGGAAGGGGAAGGAGCTCAGGTAGTCGCGGAGGACGGGGTTGAGGGGGATGCGAGCC
AGGTTCTCGCGGCCCACGGTGGCCACGATGCGCTGGCGGCACAGCTCCTGCAGCGGCCGCACGCGGCGCT
GGCGCAGCGGGGCCCCCAGCATGCGGCGCGGCGCCGCCACGTAGTGCTCCAGCAGCTCGAAGAGGCAGTC
GAAGCTCTCGCGGCTGCCATCCAGGTGAAAGCGGCCGGCCTGAAAGTGCACGCGGATGCTCGTGGGTCCC
GAGGCCATCTTCACGCTAAGGGCGAAAAAGCAGTTCCGCTGGCGGCTGTCGCGCACCAGGAAGGTGCCCA
CGGGCTCGGCGCGCAGCCGCTCGTGCGCCCCGTGCACGCTCAGGGGCCCCCAGTAGAATCCGCAGGCGTC
CAGGAGCGCGCTGGCGCGCGTGATGCGCCGGTAATCGGCGTGCGAACGGAATGTGCGGAAGTGCGTGTCG
CCGGGGGCCGGGGCCGGGACCGCGGGGCACGGCCGCGGGCGCGCGGGGGCCGCGGGCGAGGAGGAGGAAG
AGGAGGAAGGTTCTGGCCGCCGTCGGGGCTCTGCTGCTGTGGAGACTGCATTGTCGGCTGCCACCTGGTT
GTGTGCTACCATCCTACAGAAGGGGCCAGCCGGAGGGGTGGGCCATAGCGTCCGGGGGTGCGCTGCGGGA
GAGACAAAGAGGTGAGCTGGGGCGCTGCGGGGCCGGGCAGGTGTGCGCCGGCCGGACAACTCCGGAGGGC
GGCGCTCCCGGCGGACCCGGCCCTAGGGGGCGAGCACGGAGCACCAAGTCCGCGCGGATCCGTTCAGCCT
CAGTGGACACAGCTAGAAAATGGGCTCTGTACTCCGCGGAGCTCTTCCCGGCGGGTGGGGGCTCGGTGGA
GGCGGAGTCCGGCCTCCGGGCAGCACCGAGAGGGGGGCGTGGAGAGCAGCCGGTTCTGGCTCCAGCCGTC
CGGCCCCGGCTCGCCGCCCCGCGCCCGCCGCCTGCTGGCCAGGCTGGGATCCGCGCCTGGTCTGGGCGAT
TTGGGCTAGGGCCGGAGAAAGGCTGTGCTGCGGGAGCCCCGCGCGCGGGGGGCGGCCTGGGTGGGGCCGG
CGAGGGTCAGGGGCATCGCGGCCGCGACCCCATTCTGCAGCCCCCGAGGCTCGCCCGACTCCTGGCTGCC
CTGGACTCCCCTCCCTCCTCCCTCCCGCCTCCTCGCCCAGGGCCCGGCTCACCTGGCGGCGGGGCGCGGG
ACGCCGCGGGCGGGACGGCGGGGGGCTCCGGGGCGCTCCGGGGCGGCTCTCGCGCATGCTCCGGGGCCAG
GAGCCGTGCAGCTGCCACGGCCGCAGCTCGCTCTGTTC
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| Protein Name |
SOCS1_HUMAN |
| Length |
211 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
16-APR-2002 |
| Definition |
RecName: Full=Suppressor of cytokine signaling 1; Short=SOCS-1; AltName: Full=JAK-binding protein; Short=JAB; AltName: Full=STAT-induced STAT inhibitor 1; Short=SSI-1; AltName: Full=Tec-interacting protein 3; Short=TIP-3 |
| Primary Accession |
O15524 |
| Accession Version |
O15524.1 |
| Other SeqIDs |
sp|O15524.1|SOCS1_HUMAN,gi|20178097 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
[FUNCTION] Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480). {ECO:0000250|UniProtKB:O35716, ECO:0000269|PubMed:11278610, ECO:0000269|PubMed:11313480, ECO:0000269|PubMed:32499645, ECO:0000269|PubMed:33087723, ECO:0000269|PubMed:9341160}.; [PATHWAY] Protein modification; protein ubiquitination.; [SUBUNIT] Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (ELOB and ELOC). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1 (By similarity). Interacts (via SH2 domain and SOCS box) with TRIM8 (By similarity). Interacts with AXL, CUL2 and FGFR3. Interacts with INSR (By similarity). Interacts with TRIM8 (PubMed:12163497). Interacts with DCUN1D1 (PubMed:23401859). Interacts with IFNGR1 (By similarity). {ECO:0000250|UniProtKB:O35716, ECO:0000269|PubMed:12163497, ECO:0000269|PubMed:23401859}.; [INTERACTION] O15524; Q8N668: COMMD1; NbExp=3; IntAct=EBI-968198, EBI-1550112; O15524; Q15369: ELOC; NbExp=4; IntAct=EBI-968198, EBI-301231; O15524; P04626: ERBB2; NbExp=2; IntAct=EBI-968198, EBI-641062; O15524; Q04206: RELA; NbExp=2; IntAct=EBI-968198, EBI-73886; O15524; Q99961: SH3GL1; NbExp=3; IntAct=EBI-968198, EBI-697911; O15524; Q77YG1: gag; Xeno; NbExp=5; IntAct=EBI-968198, EBI-15678227.; [SUBCELLULAR LOCATION] Nucleus {ECO:0000269|PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269|PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.; [TISSUE SPECIFICITY] Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.; [INDUCTION] By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families.; [DOMAIN] The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.; [DOMAIN] The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity). {ECO:0000250}.; [DISEASE] Autoinflammatory syndrome, familial, with or without immunodeficiency (AISIMD) [MIM:619375]: An autosomal dominant, autoinflammatory disorder with incomplete penetrance characterized by autoimmune cytopenia, hemolytic anemia, thrombocytopenia, and lymphadenopathy. Additional variable features may include autoimmune thyroiditis, psoriasis or eczema, nephritis, hepatitis, and symptoms of systemic lupus erythematosus. Immunodeficiency is present in some patients. Disease onset is usually in the first decades of life, although later onset has been reported. {ECO:0000269|PubMed:32499645, ECO:0000269|PubMed:32853638, ECO:0000269|PubMed:33087723}. Note=The disease is caused by variants affecting the gene represented in this entry.; [SIMILARITY] Belongs to the SOCS1 family. {ECO:0000305}.; [WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL='http://atlasgeneticsoncology.org/Genes/SOCS1ID42350ch16p13.html'. |
| Source Db |
UniProtKB: locus SOCS1_HUMAN, accession O15524;; class: standard.; extra accessions:O15097,Q9NSA7; created: Apr 16, 2002.; sequence updated: Jan 1, 1998.; annotation updated: Oct 12, 2022.; xrefs: AB005043.1, BAA22431.1, AB000734.1, BAA23521.1, U88326.1, AAB62401.1, AF132440.1, AAD27709.1, Z46940.2, CAB92528.1, AB000676.1, BAA21537.1, NP_003736.1; xrefs (non-sequence databases): CCDS:CCDS10546.1, AlphaFoldDB:O15524, SMR:O15524, BioGRID:114203, DIP:DIP-29662N, IntAct:O15524, MINT:O15524, STRING:9606.ENSP00000329418, iPTMnet:O15524, PhosphoSitePlus:O15524, BioMuta:SOCS1, MassIVE:O15524, PaxDb:O15524, PeptideAtlas:O15524, PRIDE:O15524, ProteomicsDB:48724, Antibodypedia:4157, DNASU:8651, Ensembl:ENST00000332029.4, Ensembl:ENSP00000329418.2, Ensembl:ENSG00000185338.7, Ensembl:ENST00000644787.1, Ensembl:ENSP00000496577.1, GeneID:8651, KEGG:hsa:8651, MANE-Select:ENST00000332029.4, CTD:8651, DisGeNET:8651, GeneCards:SOCS1, HGNC:19383, HPA:ENSG00000185338, MalaCards:SOCS1, MIM:603597, MIM:619375, neXtProt:NX_O15524, OpenTargets:ENSG00000185338, PharmGKB:PA134863068, VEuPathDB:HostDB:ENSG00000185338, eggNOG:KOG4566, GeneTree:ENSGT00940000161164, HOGENOM:CLU_079452_2_1_1, InParanoid:O15524, OMA:LERCGFY, OrthoDB:1135696at2759, PhylomeDB:O15524, TreeFam:TF321368, PathwayCommons:O15524, Reactome:R-HSA-1266695, Reactome:R-HSA-1433559, Reactome:R-HSA-166058, Reactome:R-HSA-6785807, Reactome:R-HSA-877300, Reactome:R-HSA-877312, Reactome:R-HSA-909733, Reactome:R-HSA-912694, Reactome:R-HSA-9674555, Reactome:R-HSA-9705462, Reactome:R-HSA-982772, Reactome:R-HSA-983168, SignaLink:O15524, SIGNOR:O15524, UniPathway:UPA00143, BioGRID-ORCS:8651, ChiTaRS:SOCS1, GeneWiki:Suppressor_of_cytokine_signaling_1, GenomeRNAi:8651, Pharos:O15524, PRO:PR:O15524, Proteomes:UP000005640, RNAct:O15524, Bgee:ENSG00000185338, ExpressionAtlas:O15524, Genevisible:O15524, GO:0005737, GO:0036464, GO:0031410, GO:0005829, GO:0005654, GO:0005942, GO:0046935, GO:0005159, GO:0019210, GO:0019901, GO:0004860, GO:0071230, GO:0019221, GO:0045444, GO:0035556, GO:0030225, GO:0043377, GO:0046627, GO:0046426, GO:0042532, GO:0046854, GO:0043372, GO:0045591, GO:0016567, GO:0007259, GO:0010533, GO:0001817, GO:0060334, GO:0001932, CDD:cd10382, Gene3D:3.30.505.10, InterPro:IPR000980, InterPro:IPR036860, InterPro:IPR028411, InterPro:IPR035861, InterPro:IPR001496, InterPro:IPR036036, PANTHER:PTHR10155:SF4, Pfam:PF00017, SMART:SM00252, SMART:SM00253, SMART:SM00969, SUPFAM:SSF158235, SUPFAM:SSF55550, PROSITE:PS50001, PROSITE:PS50225 |
| Sequence |
mvahnqvaadnavstaaeprrrpepssssssspaaparprpcpavpapapgdthfrtfrshadyrritrasalldacgfywgplsvhgaherlraepvgtflvrdsrqrncffalsvkmasgptsirvhfqagrfhldgsresfdclfellehyvaaprrmlgaplrqrrvrplqelcrqrivatvgrenlariplnpvlrdylssfpfqi |
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