|
|
| Record Information |
| Record ID |
127 |
| Pubmed ID |
34745208 |
| SNP |
rs2167270 |
| Gene ID |
3952 |
| Protein ID |
P41159 |
| Vaccine Adverse Events |
|
| Vaccine |
Influenza Vaccine |
| Gene Name |
LEP |
| Official Symbol |
leptin [Homo sapiens (human)] |
| Aliases |
LEPD, OB, OBS |
| Other Designations |
leptin; leptin (murine obesity homolog); leptin (obesity homolog, mouse); obese protein; obese, mouse, homolog of; obesity factor |
| Chromosome |
7 |
| Location |
7q32.1 |
| Annotation |
Chromosome 7 NC_000007.14 (128241278..128257629) |
| MIM |
164160 |
| DNA Sequence |
>NC_000007.14:128241278-128257629 Homo sapiens chromosome 7, GRCh38.p14 Primary Assembly
GTAGGAATCGCAGCGCCAGCGGTTGCAAGGTAAGGCCCCGGCGCGCTCCTTCCTCCTTCTCTGCTGGTCT
TTCTTGGCAGGCCACAGGGCCCCACACAACTCTGGATCCCGGGGAAACTGAGTCAGGAGGGATGCAGGGC
GGATGGCTTAGTTCTGGACTATGATAGCTTTGTACCGAGTTCTAGCCAGATAGAAGGTTACCGGGAGCTG
GGGAGCGTTGGATTTGCTGCTGGGCTGTGCCGGTGCCCAGAAGGCAGGACCTTGCAGAACCAGCCAGGTC
CCTGGGAGACTGTCAGACCCACCAACCTGGTGGCATTCGCAGAGCTGAGATGCATTGGAAATTGCCTTGG
GCACATCCCCAAAGATCAGGATGTCCCACCCCAGTCTGAAGGAGATAAAGTTGGGGGTAGGAGAGACGCA
GATGCAAGTGATCAGTCTCAGTCCCAGACATTGCCTTGCTCTGCGGGTAGGAATTCAGGATTCATTTTCC
AGGGAAGTTCCTGACCTCTGAATGAGAGGGGCTGTGTAAGGCCAATGCCTGGGAGGAAGGCAAGGATGAG
TAGAGGTGGGGGGAAACAAGTGTCAGGAAGACTCAAAATCTTCCAGAGAAATTGTGCAGGGTCTTACCAG
ATCTGTCCTCAAAGCCATGCAAATTGCCTTCTTTGCAATGCATACAATGAGGTGTCTCTGGGGGTCAGAA
CTGGTTATTAGGGAACTTCTAGCCAGGACTGCTAAATACGCGCTGTTGGCCCACCAGGCTCACCTATAGC
CTTCCTTCAGTCTGGGCTTGGTTTGGATTTCACTGTGGGTGCCATCGCCTTTACACTCCTGTTTCTATAG
TTTAAAGATAGTGGTGCTTTGGGAAAGTGACTCCTTAAATACAGTTAGGTCCAAGTGAGACAAGTGGCCT
GGCTGTCATTTCAGAATAGCAGCTTCCAAGAGGTGATTAATTTCTGTTGGAAGGGTGATCTTTGGGGAGG
TGGGTGAAGAGCAGAGACTTGGTGGTACCGTTCCAGGAGCACAGGCTCTCTTCCTTTGCAGTGCAGAATG
ACCTCTGGCAGCCGGAGTTGTGTTTGTTCTGTAGGATTCTGAGGTGGGCCATGGGCAGCTGGAACTGGGG
AATTTTGCCAATCTCTTTCATATTAGGATTGTCTGCAGAACCAGATATGGAGGCTTCTAGCAACGTGAGT
GCTCCTGTTCTAATGCCCTTAGAAACAAGAAGGCCACACTGATCATTTCTCTCACTTAGGCAGGGAGACA
AGGCAAGAGAGAAACAGTGGATGCTTTTAGGTTCTTTCCCTTCCCAAGCAGTTGTGGACATTGGGCTGAG
GGGAACATTTCCACATTGGCTAAAGGAGCGTCCTCCTCATATTTTGTACATTTTATACCCAAAATAACTC
TTCTTGGTATTTGGGGAAATATTTTCCTCCCCGTCCATTCCAGGAAATGGCTCCAAGTGCCAAGGACAGA
GCCAGGGAAGTTGCAATGAATTCCTGCCCGTCAGCCCCAGGCAGATGCCTTGCACGTCTGAGTGGCCCAT
GCAGAGCGTGGAGGTGGCCGCCACGGAACCTGGGTCAATGTCCCACCCCCGCTTAGATGCCACCAGGGGC
GTGGGAGCCAAGGAGAGAAGAGGGGCTCCAGGAAGGTAGAGTCCTTGTGTCTTGTGCATCTGTGAACAGC
ACTGGTATGATTTAAAGGAAAATTGAGCCAAATTTTCCGGCAGTCAGTTACCCCATCCCCACCGGGGTAG
GAGTCTGGCAGCCGCAGCTCCATTCTGGCCAGTCGGCAGAGAGCCTTGAAATTCTTCTTTGTCCACACAG
TTGTCTCAGAGAAACAGAGAGGTTGTTTCTGCTTAAAAACAACACACTTGGTGTCTGGGCCCACAGACTC
CTTTGCACTTATTCCACGTGTGACAGCCAATGTGCCTCGTTGCTTAGCAGACAGCATGTTACCGTCTTTC
CTGCTCAGTTTGTTAGCTCTATGGAATGGAATTTATAATCAATGCCCATACCAACATTTCACTAATATCA
TAGGAGATTTAGTCTCCATCTGGGTGTACATTACATTTGCTCTGGGGTGCTCCAGGCTGGGGGGTTGCCA
AGGAAGAGAAGAGAAACCGCAGAGAAGACGGGAGGGCAGGGCAGGGGTCTCTGAGAAGGGGAGGGGTCCC
AGAGTGCAGGAGCAGGAGCCAGGCTCATGAAAGGGGCCACGGGCGGGAGTATCCAGGGACGGCAGTCAAG
ATGGAGCACAGCTTAGGAAGCTGAAGGGAATCCTGGCCCACCTGGGTGCTAGAGGGCACATAGGAAGTGC
AGGAAGCAGACCAAGGTCCCCAAGAGAGGGAGACCTGGACGCTGAAGCATTTTCTGTCTTTATTAAGACA
ACTCCGTAAGAATTCCTGCTGGGCCAAAGTGAATTCTAGGATGCGACTTTAAGATGGGAGCAAGCGAACC
ATTGAGGAGGCAGGTTACCCTAGTTAGCCAATGCAGATCGAGAATGGGAAATCTTTCATTTATTCATGCA
ACAGATATTTAACGAAGCCCTGCCGTGTTCCAGGCCTGTGATAGATGCTGGAACAGGTACAGAGATACAG
GTGTCATTAATTGATCAGGGCAACCTCTCCTTCTGAGTCTTGCTGGAGCTTCAGATGCCCCTCACACAGA
GCTCGAGGGAGCCTCAACAATTGATCAGAAGTCAGGCACCATGGCTCACGCATATAATCCCAGCACTTTG
GGAGGCCAAGGCAGGTGGATCACTGGAGCCCAGGAGTTCCAGATCAGCTGGGGCAACATGGCAAAACCCC
ATCTCTATTAAAAAAAAAAAAAGTAACTGGATGTGATGGTACACACCTGTAGTCCCAGCTACTTGGGAGG
CTGAGAGGTGGGAGAATTGCTTGAGCCCGGGAAGTCGGGGGTCCAGTGAGCCTTGATCACACCACTGCAC
TCCAGCCTGAGTGACAGAGCAAGACCCTGACACACACACACACACACACACACACACACACACAGATTAG
AGCTGAAACAGGAGTAGAAACCTATCTGTATCTCTGATGAGATCAGATCTTTCTGATGAACAGAAAGAAT
GTAACCCCTGTACTCACACCCTCTCTGCTGGTTACATATGTTAACACGATTTCTCAAATGAGGCTTTTGG
TTGCAAATAAGAGAAAATCACTCACGCTGGCCCTGTGTTTTTCAAATTGTTTATTGTGATCAACATTTGA
AAAAAGAGCCGAGACTCTCAAGAGTGCATTACCCACGGTAAGGGTGAATTTTACTTCTTGACACTTATTT
CTCTTACATGTATCTATCTGTCTCAAATGAAAAATATATTTAGAAAGTTGAAAGCTATCCAAGTGAGTAT
AAGAAAAGAGTATCTCACCCTGAAGGCTAAGGACAGGGAGGGCCACCAGGCCTCACGAGGACCCAGGAAC
CACAAAGAAGGCTAGGAAGGAGCACAGGCGGTGACCATACTCTGGCTCAGTGGCTATGTGGGCTCTGGTC
TCTCTCAGCTGTTCCATGCATATGAGGCCAAATGTGGCTACCCTAGAGCTTCTGAGCCCTCAACAGAGAT
GAACTGGACTCTCTGCAGCCCCACTCTAAATTCCTAAGAGAGAAGTTGATTGACCCAATCAGGGTCAGGA
GAAGGAAGGGAGGAGGAAAGGGAGGAGAGAAGAGCCTCTTCGTCTCTTGCCTACCACTGGCCAGGCAATT
GTAGCCAAGGGGGCTGGAGTGTAAATGCAAACATAGCCATCAAGGGTTGTGTATGTGTGTGTGTGTGTCT
GTGTGTGTGTATGTGTGTCTCTTGGGTAGGTTAGATCTCCCAGGAGGTCCCTACTAAACAGACTTAAGCC
CGCAAAATTTTAGCTCTCCAGCCTCACACACTCCACCCCTCTACCATATTGAATCTTCCCAAACCAACTA
TGGCTTTCCCTAACTCCGGAGCTTGGCCTGGAATGCCCTGCTTCCCCTCTTTCCCCTGGGGAACGCCTGT
CCTTCAGGCCTCAGTTCACACACTGCCTCCCTTGCAAAGCTCTCCTCCCATCCCCGGAGTCCCTCTTCCC
CTTTGTTCTTTGGGTTCTATGCTTCTTCCCTCATAACTCCCACCAGGTTGTGTTAAAATGAGTTGTTCAA
GGTCCTGTCTGTTCCACTAGATTCTGAGCAACTTGGAGAACGAAGATCCAAACTTCGCTGCCTTTATTTC
CTCCTTTGTTCTTTTCTCATCCCCAAGTCCCTTCCAACTTGGAGTTATGAAGAAAGGAAGGAAGGAAGGG
TGGGAGGGAAGAACAGGAGGGGATCCCACAGGAGAATGTGTATAGGGAGAGGACTCAGACTAGCTAAAGC
TTTTCCCTCATAATTAATAGCAAATACCATGTTACCTGAATTTAATTCACAGTAGCATACAAAAGACTCG
CTTTGTTCTCCCCATTGATGTCATCAGAGGGCTGTGGGCAGGCCTAATCTTGGCTCAGGAGGCCCTCCAG
CCTGGATCTAAAGAGCAGCAGATGGGCCAGGCTCGGTGGCTCATGCCTGTAATCCCAGCATTTTGGGAGG
CCGAGGCGGGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGGCCAAGATGGTGAAGCCTCGTCTCTA
CTAAAAATACAAAAATTAGCCAGGTGCGGTGGTGGGCGCCTGTATTTCCAGCTACCCGGGAGGCTGAGGA
GGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGGTCACGCCACTGCAC
TCTAGCCTGGGCAACAGAGCAAGACTCCGTCAAAAAAAAAATAAAAAAATAAAAAAATAAAAAAAATAAA
GAGGAGCACACATCTCTGCCCATCCTAACTCCCACTTTGACATTGAGGTCCCCAGGATGGAGGGTCTGCC
TCCATCTGCCTTGTCCCCTGCAATGGTGGGAAGGTGATGGAGCTCAAGTCTAGAGGCCACCAGCTTCTTA
GGGAGGTAGGAGGTGGAGGGTGGGGTGCGGGCCCTGCACACAACTGCCAAGTGAGGATGGGGGTGGGGTC
CACCTGAGGATAAGTAACAGTGAGGCTGGTGCAGAGGACCCAGGTGGAGGTAGACAGCAGAATTTGTGGT
GGGGTGGATGGCACATTATATAAGCCTCTCTTGCTGCCCTGTTTACTGAGATTGTTTCATTATCTTTTTT
GGCTTTTGTTTTTAAGAGATGGGGTCTTGCTGTGTCACACAGGCTGGAGTGCACTGTGTGATCATACCTC
ACTGCAGCCTCGACATCCTGGGCTCAGGCAAACCTCCCACCTTGGCCTCCCAAGTAGCTGGGACCACAAG
CGTTTGCCACCACACTCAGCTATTTTTATTTTTATTTTTATTTTTTTTAGAGATGGGGTCTTGCTGTGTC
GCCCAGGCTGGTCTTGAACTCCTGGGCTCAAGCGATCCTCCTGCCTTGGCCTCCCAAAGCCCTGGGATTA
TAGGCTGAGCCACCACACCCAGCCACATTTCATCTGTGCAGCTCCAGGGGCTCCACATTCTACTCTTCTC
ATTTCTTCTCCAGGGTACCCATGGCAAGGGATGAGGGTAGAAGATGGGGCAGCCAGGCCTTGATTAAAGG
AGAAGGAAGGCAGCCTGTGGAGAGGGCAGCCCAGGGAGTGCAGAGAGAAGTGGGCCATGAGGGAGACAGC
AGAGTGCAGGCTGCGTCCCAAATGAGCATACAGCCCACTGTGAGCCCACCATCTTCCTAGAGACCCCTCT
CCTCTCCAGGAGCTGCTTCAGTAGCACTCAGAGGAAAGAATGATGCTGTATCAACATTTCAGCAGCTCAT
CTTTTAACTCTAAGAAAATGGCAGCTCCTAAATGTTCAAAACTGCTTTGGAAACTTCTGGAGAGAGGTTT
TGCAGCTCAGGCAGACAGCTGATCGCGGCCTTTCTTCCACCCCAACCCATGCTCTCCCCATGCTCTCCTG
CCACAGCTGCAGCGGGCCCCTGGGTCCTACATTTGCAGCCCTTTGTCTCTGAGCTCAGACTTCCAATTCC
AAGCGGCAGCTGGGCAGGCTCACCAGCATGTCCAGCCAGTACTAGGACATCAGCAGGAGCCCAACCACCT
CTTTCCAAAATCTCTCCTCATGTCTCTCCTAGTTTCCATCTCCATCCTTCTAGTCAGCCAGGCTGAAAAC
ATTTGCTCCTCAGGGTGCAGAAGGGAAAGCTTTGCCTCCCTTCCTGGTGCTCACTGCCCCTGCGATTCCA
GCCCAAGCCCTCCCCGGCTCCTCACCCTGGTGTCAGCTGGAAGCCACCATCTCCTAAACCCACCTGTGTT
CTTCCACCTCTGCCAGGGCTGCCCTCTCCTCCACCTTCACAAACTCAATTCCTACCCATTCTCAGGTCCC
TTATCAAATGCCATCTCCTCCATGATGCCTCCCTGATTCCCCTGCTGGAAATAATGGTGATAACAGCTAA
GGCATTGGGGTTGGCTACGTGCCAGGCAAGGAGTTGGCACTTTACATGCTTTATCTCATTTCAGCCACAT
AACATCGACAGGTGGCATTATGATTCATATCATCCCCATCTGATAGCCAGGAAAACTGAGTCCCAGAGAG
GTTAGCCACTTTCCTAGGGCCCTGTGCTCTGACTCAAGCATAGCTCTGAGGAACTCTAGCATTCATCAGT
TTAAGCACCATGACTTTCTTTGCTGAGTCACCCAAGGCATTTCTTCATTTAAATGTTCTTCCTTGGCCAG
GCGCAGTGGCTCAGGCCCAATGCGGTGGCTCACGCCTGTAATCTCAACACTTTGGGAGGCCGAGGTGGGC
AGATAATCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATA
CAAAAAAATGAGGCTGGGCGTGATGACTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGG
ATTACATGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTATCTCTATTAAAAATACA
AAAAATTAGCCAGGCATGGTGGCAGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAAAATGG
CTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGGTTGCACCATTGCACTCCAGCCTGGGCAAAAAGA
GGGAAACATCGTCTAAAAAAGAAAAAAAAAAAATTAGCCAGGCTGGGTGGTGCATGCCCGTAATTCCAGC
TACTCAGGAGGATGAAGCAAGAGAATTGCTTGAACCCAGGAGGCAGAGATTACAGTGAGCTGAGATCACA
ACACTGCACTCCAGCCTAGGTAAAGAACAAGACTCCATCTCAAAAATAAATAAATAAAAATAAATGTTCT
TCCTTGCAATGAAGTTAAATATGTAAATTCTCAAACCAGTTGCTTAAGGGCACAGTTTTGTTCTTTACCT
ATATTTTTAACAAATATTTTATGTAAGTAGTTGACAAAATCAAATACTGTGTACACTACCGAGGCTTCCC
TGGGAAAGCCATCAGCCTCTGCCCCATCCCTTCCCACTCCTGATTCCACTTTCCTGTGTTTCCATATCTT
TTTCATGTCTGTTTCTGGCCCACAGTGGGCGATCAATACATGTTAGCCACCAACCATCAAACCTATATTG
AGTAATTATGGTATGTCAGGCACTATGCTCAATGAAATTGTATTAGGCTTGTACAAAAGTAATTGTGGTT
TTTAAGAGTAATGGCAAAAACGGCAGTTACTTTCGCACCAACTATTTGCTGCCTTGAATTATTCCTCCTC
TCCTCATCCCTAAACCCTGCTCCTCCCAGCCATTCTTCCTCCCCTTCTTGGGCCATGGCCAGGCCCCACC
CAGGTACTAAGACTCAGGTGAACCAAGGAAGACTTAATGCCCACTCTTTTCTGATGCCCATGTTGGCATG
TGTTAAGTCGGTTAGCATTAAGTTTGGCTGCATTTAGCAGAGACCCAAAAGAACAGTGCCTTTTAAAAGG
CAGAGGTTATGTCTCTCACACACACCCAGCACAAGTCCAAGACCAGCATGGCATCTCAGCTCCATCAACC
TCAGGAACCGAGCTCCTGCAGCTCCCTGCCCTGCAGTTGATAAGGTGAGGTCTTTGTCCTCCTGGTTCAA
GATGGTGCTAGAATGTTGGCTACCATATCTATAGTCCAGGCATCAGAATGGAGCAAGGGATGAAAAAGGA
AGAGATGAAGGCACACGACAGGTTCCTGAGAGCTGGCACAGGACACTTCTGCTTATATTTCACTGGCCAG
AACTTAGTCACATGGTCACACCTAGTTGGGAGACTCTGAGAAGTAAAGTATTTATTCTAGATGGCCATAT
CCCTACCTAAGACTTGGAGTTTTCTATGACTGGGGAAGAACGGAAGACAAGATATTGGGAAAGACTAGCA
GCCTCTACTAAAAGGGTGATCTGTGTTGATGTGCGTGTGTGTGTGATGTTTGTATGAGCATGTGTGTTAT
GTGTTGTGTGTTGGTGGGGCAGATTCTTGCGAGCACTTTGGTCTCAGATGGACCTGCTACCAGTTCTCTC
TGCAGACCCCCATAGGTTTCTCCTAAACCTGGCCTCTCCTATTAGGCAGCCTTACTCAGCGGCAGCTTCT
CAGCTCCATGTTTTCAAGGAACCACAATTTATTTCCAGCATCCACTGAAGCATATTATCAGTGGTGATAG
AGGGGGCTTGTAAAACTGTTTTTCCACTTAGGTATTAGAGGGTGGCCATTATTTGAGAGTGACTATGACC
ACAGTTAATCTGGTAATAAATTCTCTTGGGTAGGAGGAAAGGAAAGGATGCTTTAAGGAAGCATCTTGCC
AGGAGACACAAAGCTAACAAGAGTGGAGCCTGCAGCTGGAGCCGCAGAGCCTAATCACTACACCCGCCCA
TCTCTGCTAGGGTTTCATGACTTCGTATCGGGGATTAGCAGTATTTAACTCTGTTGCACAAACATTTGGT
GTATTATTCAGGTAACAAGTAGCTAATAGAGGAAGTTTTACTTTTTTAAGACATAAATTTGCCTTTTCCC
AAATTACTTGGTACATAGTACTTTTCATGTTTGAAGTTGAGATGTGGGTACAATACCATAGCTTTATTCC
AGAGCAGGGTATTTGTTTCCAAATGCCATGTTCCCAGCAGCTGCCCTTGACTGGGAATTGGGGTGTGATT
TGGGCTTTTCCTTAAATCCTTGAGGAGCTGGAGGGGTGGGTGGCTCGCACTCCTGCTTTCTGGATCTGAA
TCCTGACTCTGTCATGGACCTGTTTGACTTTGGGCAAGTTGACTCCTATTCCTGAGCCCCATATTTTTCT
CTTCTGTGAAATTCAGATTAAAAAAACATGGCTTTGATCAAACATTATAAATAATATATAGACAGACTGC
TTGTTTTTATTGTATTGCCAGAAATGAATCCTACTAATATTGCCATCTATGGACAGAAAATGTATTACCT
GTCTTCATCAAGACCCAGACGAGGAAGAACACGAAAAGCGGAGATTAATTTTACTGCCATCTCCAGAACC
GTCATCCTAATATTTACTTACATTTTATTATTATTTCAGGCTCATGCACATATACTTAGCATGGATCATT
GGCCACAGACTCGCATACATTTAACTTTATTACCTTTTGCCTCATGTATCTCATTAAAATTTTGCTGCTT
AATCAAGGATCTGCATATTATTTTAATTTTAGAATTCACAGTTCCAAGACTTTGAAAGTTTCAAGCGTTC
TGGGTGAATGTGTTATGCTCTCTCCCGCCACCATGTCTTTATACCCCCTGATTTCTCAGCCACTATGGCA
ACCACTTTCTACTCTTAGTAGCCCATATTTAGTCCAATCCCCAGCTCAGGAGACACTTCTTCCAGGGAGC
CCCCTGTGCCTTCCAGTAGTATCTTGTACCTGCCCTTTTTGCAAAGCTCTTTCCTCCTGGCTTAGAATGG
CCCATTGACCTGTTTGTTTCTCCTATTAAACTGTAAGCCACTCGAGGGTAGAGAGCATCTGTTGTTCACC
ATTGCATCCTCGGTGCTGAGCACTGCGTCTGACATATTATTTAGAAGGTCAGTAAGTGCTAGTGGGATTC
AGGCTCCCAGTGGGTGGGAGAGAAAGGACGTAAGGAAGCAAGTGGTAAAGGCCCTCACAGAGTATCAGCA
GGCTGGTGTGAGGGAGAAATGCAGAGGATGGGTGAGTAGCATAATCGCTAATGATAGGGTAATGATAGAG
CACATTTCACAACACCTTTAAGCCCTTTCACGTGCATCAGATAATTTGATCCTCATAAAAGCCTAGAGAT
AGATATATTACAGGGATGAAGGTGGAGTATTTTGTGGTTATGTGATATGTTTAAAATTATGCAGTGAGTA
AATGACTGGGTTCAAACCAGACCTTAAAAGTCTGTTATCTTTCCCTCGAGCATGCAATGAAGTCTACATC
ATCCCTACCATGTCCATTTGATCACACCCTGGCCTCACAGCTCTGTGGTCTACAGGATACCTCATGGTGG
TTTTATTGACCAGACAATAATCCTCTTTCTAAGGGGATGCATTTCATTAATACATATGTAGATCATGAAT
TGTCTTTGACTTTGAGGGGATGGTAGCCAGAGCAGAAAGCAAAGCTGATTTTCATCCCCGTCTGGTAATG
TGGTTGGTAATGTGAAGATGGGTGTATTCTGAGATACCGGCTCCTTGCAGTGTGTGGTTCCTTCTGTTTT
CAGGCCCAAGAAGCCCATCCTGGGAAGGAAAATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGG
CCCTATCTTTTCTATGTCCAAGCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGA
CAATTGTCACCAGGATCAATGACATTTCACACACGGTAAGGAGAGTATGCGGGGACAAAGTAGAACTGCA
GCCAGCCCAGCACTGGCTCCTAGTGGCACTGGACCCAGATAGTCCAAGAAACATTTATTGAACGCCTCCT
GAATGCCAGGCACCTACTGGAAGCTGAGAAGGATTTGAAAGCACAGGGCTCCACTCTTTCTGGTTGTTTC
TTTTGGCCCCTCTGCCTGCTGAGATTCCAGGGGTTAGTGGTTCTAATTCTAAACCACTCCAAGAACATTT
GATTTTGCTACATGTTTCCATTTAAAAATCATAGGATTTGGGCTGGGTGTGGTGGCTTGTACCTGTCATC
CCAGCACTTTGGGAGGCCAAAGCAGGAGGATCATTCGAGCCCAAGAGTTCGAGACCAGCCTGGGCAGCAT
AGGGAGACCCCATCTCTACAAAAATAATAAAAAATGTTAGCTGGGCATGGTGGTGTGTACCTGTGGTCCC
AGCTAGGGGAGGCTGAGATGGAAGGATCACCTGAGCCTGGGAGGTTGAGGCTGCAGTGGGCCCTGATCAT
GCCACCGTGCTCCAGCCTGGGTGACAGAGTGAGACCTTGTCTCAAAATAAATAAATAAATAAATAAAAGT
CATAGGATTTGATCAGGCATGATGGGTCACATCTGTAAGCCCATTGCTTTAGGAGGCCAAGGTAGGAGGA
TCAGTTGAGGCCAGGAGTTCAAGACCAGCCTGGGCAACATGGCAAGACCTCTCTCTCTAATTTTTAAAAA
AATAAAAATTAAAGATAAGAAAAAAATCATAGGATTCTCATGAGGCCTCACGTGCTTATTTTCAACCTAC
CAAGGGGAAACCCAGGCCTCAGCGATTAGCTGAGCCACATGCAGGCACAGCCACTGTCTCTTTCCTTCCT
GTCCCCTCTGTCCCCACCTTCTGCGCTCGCCTTCCTCCCTGACTTCACTTCCTTGAATCTTAGTGCCTAC
GACCAGAGGGAGCTGTGAAGTTCCTTGTGTCCCATTGGCAGGAACAAGACCCCCAGAAGCATCTCCTCAG
GGCCTCTATCCCATCTCTAGATGTGCTTGTCATTAGGGTTCTTGTAGTTCCAGCTGATCTCTGGCCCTGC
CGCTCAAAGATACCCAAAAGAGCGAGTCTACCCTTTTTCACATTCAACCCTCTACTGATTTGCAAATAGC
AGTCAGTGCCCACCCTGGTCTTTTCTCTGGGGTCCAGCAGGCCTAGACCTTCAGCCATTTTCCTGATGAG
GTCTGTATTTGAAATTAGGAAGATTAAGTTTGAATCTTCACACTTCTGATGTCTGTGAGATCTTCAGCAA
GTTCCTTACTGTCTTTAAGCCTTGTTTTCATCATCTGGATAATGGGGATATCACACACTATTCACAAGGT
TGTTATGAGGCCTAAATTAGCTAAAGCAATTGAATCCTCCTTACCCCCTGCATGGAGCTCTCTGGAGACT
TCCACGTCTCCTGGTCATTGTGGGTGTCTTATGGTAGTCTTGGGCAGTTAGGGAGAAGTTAGGTGTCTGG
AAGCAAAGATGGCTCAGAACTAGATAGAGTCTTGGGCATTTTATAGATAAAAACTCTTGTCTCCTTTAAA
AATAATAAAAAAAAATTAGCTGGGCATATTAGCCACTCAGCAAGACTGCACGTGATAGATCCCGAGTGCC
CCACCTTGGGTGGTGTAATACACAATATCACGGGAGCCCCGGGTAGTAACCACGGAGGTGTCAGCCTCAG
TGCTGTGGGCAGATGGATGGGGAGAGCCTCCCGGAACTGGAGTCACTGGAGCAGGGTTGGGGGGCCTCAC
TGAGGGTACGGCCTTGATCTCTAAGGAGGAGGGACTGCCTGGAAAAGCTGACTGGGAGGGAGGACTCGGC
TGGGGGTAGAAGGGACTAGGGAAGGCTGGGGGTGGGGGTGCTTATGGAGGACCTCAGATGCCTGGGGAAC
AGACTCCACTAAATAAAACATATGAAACCATGGCTGGTTCTTCAGCAGAGGCCATGTAGAGAAAGGAATG
ACCTAGGAAAGTTGGCCTGGAAGTGGAGGGAAGGATGGTGTGGGAAAAGCAGGAATCTCGGAGACCAGCT
TAGAGGCTTGGCAGTCACCTGGGTGCAGGATACAAGGGCCTGAGCCAAAGTGGTGAGGGAGGGTGGAAGG
AGGCAGCCCAGAGAATGACCCTCCATGCCCACGGGGAAGGCAGAGGGCTCTGAGAGCGATTCCTCCCACA
TGCTGAGCACTTGTTCTCCCTCTTCCTCCTGCATAGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTT
TGGACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCAGTCTACCA
ACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGACCTGGAGAACCTCCGGGAT
CTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCCTGGGCCAGTGGCCTGGAGACCTTGGACA
GCCTGGGGGGTGTCCTGGAAGCTTCAGGCTACTCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTC
TCTGCAGGACATGCTGTGGCAGCTGGACCTCAGCCCTGGGTGCTGAGGCCTTGAAGGTCACTCTTCCTGC
AAGGACTACGTTAAGGGAAGGAACTCTGGCTTCCAGGTATCTCCAGGATTGAAGAGCATTGCATGGACAC
CCCTTATCCAGGACTCTGTCAATTTCCCTGACTCCTCTAAGCCACTCTTCCAAAGGCATAAGACCCTAAG
CCTCCTTTTGCTTGAAACCAAAGATATATACACAGGATCCTATTCTCACCAGGAAGGGGGTCCACCCAGC
AAAGAGTGGGCTGCATCTGGGATTCCCACCAAGGTCTTCAGCCATCAACAAGAGTTGTCTTGTCCCCTCT
TGACCCATCTCCCCCTCACTGAATGCCTCAATGTGACCAGGGGTGATTTCAGAGAGGGCAGAGGGGTAGG
CAGAGCCTTTGGATGACCAGAACAAGGTTCCCTCTGAGAATTCCAAGGAGTTCCATGAAGACCACATCCA
CACACGCAGGAACTCCCAGCAACACAAGCTGGAAGCACATGTTTATTTATTCTGCATTTTATTCTGGATG
GATTTGAAGCAAAGCACCAGCTTCTCCAGGCTCTTTGGGGTCAGCCAGGGCCAGGGGTCTCCCTGGAGTG
CAGTTTCCAATCCCATAGATGGGTCTGGCTGAGCTGAACCCATTTTGAGTGACTCGAGGGTTGGGTTCAT
CTGAGCAAGAGCTGGCAAAGGTGGCTCTCCAGTTAGTTCTCTCGTAACTGGTTTCATTTCTACTGTGACT
GATGTTACATCACAGTGTTTGCAATGGTGTTGCCCTGAGTGGATCTCCAAGGACCAGGTTATTTTAAAAA
GATTTGTTTTGTCAAGTGTCATATGTAGGTGTCTGCACCCAGGGGTGGGGAATGTTTGGGCAGAAGGGAG
AAGGATCTAGAATGTGTTTTCTGAATAACATTTGTGTGGTGGGTTCTTTGGAAGGAGTGAGATCATTTTC
TTATCTTCTGCAATTGCTTAGGATGTTTTTCATGAAAATAGCTCTTTCAGGGGGGTTGTGAGGCCTGGCC
AGGCACCCCCTGGAGAGAAGTTTCTGGCCCTGGCTGACCCCAAAGAGCCTGGAGAAGCTGATGCTTTGCT
TCAAATCCATCCAGAATAAAACGCAAAGGGCTGAAAGCCATTTGTTGGGGCAGTGGTAAGCTCTGGCTTT
CTCCGACTGCTAGGGAGTGGTCTTTCCTATCATGGAGTGACGGTCCCACACTGGTGACTGCGATCTTCAG
AGCAGGGGTCCTTGGTGTGACCCTCTGAATGGTCCAGGGTTGATCACACTCTGGGTTTATTACATGGCAG
TGTTCCTATTTGGGGCTTGCATGCCAAATTGTAGTTCTTGTCTGATTGGCTCACCCAAGCAAGGCCAAAA
TTACCAAAAATCTTGGGGGGTTTTTACTCCAGTGGTGAAGAAAACTCCTTTAGCAGGTGGTCCTGAGACC
TGACAAGCACTGCTAGGCGAGTGCCAGGACTCCCCAGGCCAGGCCACCAGGATGGCCCTTCCCACTGGAG
GTCACATTCAGGAAGATGAAAGAGGAGGTTTGGGGTCTGCCACCATCCTGCTGCTGTGTTTTTGCTATCA
CACAGTGGGTGGTGGATCTGTCCAAGGAAACTTGAATCAAAGCAGTTAACTTTAAGACTGAGCACCTGCT
TCATGCTCAGCCCTGACTGGTGCTATAGGCTGGAGAAGCTCACCCAATAAACATTAAGATTGAGGCCTGC
CCTCAGGGATCTTGCATTCCCAGTGGTCAAACCGCACTCACCCATGTGCCAAGGTGGGGTATTTACCACA
GCAGCTGAACAGCCAAATGCATGGTGCAGTTGACAGCAGGTGGGAAATGGTATGAGCTGAGGGGGGCCGT
GCCCAGGGGCCCACAGGGAACCCTGCTTGCACTTTGTAACATGTTTACTTTTCAGGGCATCTTAGCTTCT
ATTATAGCCACATCCCTTTGAAACAAGATAACTGAGAATTTAAAAATAAGAAAATACATAAGACCATAAC
AGCCAACAGGTGGCAGGACCAGGACTATAGCCCAGGTCCTCTGATACCCAGAGCATTACGTGAGCCAGGT
AATGAGGGACTGGAACCAGGGAGACCGAGCGCTTTCTGGAAAAGAGGAGTTTCGAGGTAGAGTTTGAAGG
AGGTGAGGGATGTGAATTGCCTGCAGAGAGAAGCCTGTTTTGTTGGAAGGTTTGGTGTGTGGAGATGCAG
AGGTAAAAGTGTGAGCAGTGAGTTACAGCGAGAGGCAGAGAAAGAAGAGACAGGAGGGCAAGGGCCATGC
TGAAGGGACCTTGAAGGGTAAAGAAGTTTGATATTAAAGGAGTTAAGAGTAGCAAGTTCTAGAGAAGAGG
CTGGTGCTGTGGCCAGGGTGAGAGCTGCTCTGGAAAATGTGACCCAGATCCTCACAACCACCTAATCAGG
CTGAGGTGTCTTAAGCCTTTTGCTCACAAAACCTGGCACAATGGCTAATTCCCAGAGTGTGAAACTTCCT
AAGTATAAATGGTTGTCTGTTTTTGTAACTTAAAAAAAAAAAAAAAAGTTTGGCCGGGTGCGGTGGCTCA
CGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGGGGATCACAAGGTCACTAGATGGCGAGCATCCT
GGCCAACATGGTGAAACCCCGTCTCTACTAAAAACACAAAAGTTAGCTGAGCGTGGTGGCGGGCGCCTGT
AGTCCCAGCCACTCGGGAGGCTGAGACAGGAGAATCGCTTAAACCTGGGAGGCGGAGAGTACAGTGAGCC
AAGATCGCGCCACTGCACTCCGGCCTGATGACAGAGCGAGATTCCGTCTTAAAAAAAAAAAAAAAAAAGT
TTGTTTTTAAAAAAATCTAAATAAAATAACTTTGCCCCCTGC
|
| Protein Name |
LEP_HUMAN |
| Length |
167 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-FEB-1995 |
| Definition |
RecName: Full=Leptin; AltName: Full=Obese protein; AltName: Full=Obesity factor; Flags: Precursor |
| Primary Accession |
P41159 |
| Accession Version |
P41159.1 |
| Other SeqIDs |
sp|P41159.1|LEP_HUMAN,gi|730218 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Mar 15, 2005 this sequence version replaced gi:2144649, gi:2135555.; [FUNCTION] Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:8589726, PubMed:11460888, PubMed:19688109, PubMed:24340098, PubMed:25060689). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (PubMed:24340098). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (PubMed:12504075). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (PubMed:15899045, PubMed:19688109). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (PubMed:25060689). {ECO:0000250|UniProtKB:P41160, ECO:0000250|UniProtKB:P50596, ECO:0000269|PubMed:11460888, ECO:0000269|PubMed:12504075, ECO:0000269|PubMed:15899045, ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580, ECO:0000269|PubMed:19688109, ECO:0000269|PubMed:24340098, ECO:0000269|PubMed:25060689, ECO:0000269|PubMed:8589726, ECO:0000305|PubMed:15122202, ECO:0000305|PubMed:25232147}.; [SUBUNIT] Interacts with SIGLEC6. {ECO:0000269|PubMed:10428856}.; [INTERACTION] P41159; O75031: HSF2BP; NbExp=3; IntAct=EBI-12994693, EBI-7116203.; [SUBCELLULAR LOCATION] Secreted {ECO:0000305|PubMed:25232147}.; [TISSUE SPECIFICITY] Adipose tissue is the main source of leptin. It is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907). {ECO:0000269|PubMed:10896907, ECO:0000269|PubMed:12448771, ECO:0000269|PubMed:16052473, ECO:0000269|PubMed:7789654}.; [INDUCTION] Induced by secretin. {ECO:0000269|PubMed:10896907}.; [DISEASE] Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age. {ECO:0000269|PubMed:25551525, ECO:0000269|PubMed:9500540}. Note=The disease is caused by variants affecting the gene represented in this entry.; [SIMILARITY] Belongs to the leptin family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Leptin entry; URL='https://en.wikipedia.org/wiki/Leptin'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/lep/'. |
| Source Db |
UniProtKB: locus LEP_HUMAN, accession P41159;; class: standard.; extra accessions:O15158,Q56A88; created: Feb 1, 1995.; sequence updated: Feb 1, 1995.; annotation updated: Oct 12, 2022.; xrefs: U18915.1, AAA60470.1, D49487.1, BAA08448.1, U43653.1, AAC50400.1, U43415.1, AAC31660.1, D63710.2, BAA09839.1, D63519.2, BAA09787.1, AF008123.1, AAB63507.1, AY996373.1, AAX81413.1, BC060830.1, AAH60830.1, BC069452.1, AAH69452.1, BC069527.1, AAH69527.1, LTHU, I53166, NP_000221.1, XP_005250397.1, 1AX8_A; xrefs (non-sequence databases): CCDS:CCDS5800.1, PDBsum:1AX8, AlphaFoldDB:P41159, PCDDB:P41159, SMR:P41159, BioGRID:110143, DIP:DIP-6116N, IntAct:P41159, STRING:9606.ENSP00000312652, iPTMnet:P41159, MetOSite:P41159, PhosphoSitePlus:P41159, BioMuta:LEP, MassIVE:P41159, PaxDb:P41159, PeptideAtlas:P41159, PRIDE:P41159, ProteomicsDB:55406, Antibodypedia:3389, DNASU:3952, Ensembl:ENST00000308868.5, Ensembl:ENSP00000312652.4, Ensembl:ENSG00000174697.5, GeneID:3952, KEGG:hsa:3952, MANE-Select:ENST00000308868.5, UCSC:uc003vml.3, CTD:3952, DisGeNET:3952, GeneCards:LEP, HGNC:6553, HPA:ENSG00000174697, MalaCards:LEP, MIM:164160, MIM:614962, neXtProt:NX_P41159, OpenTargets:ENSG00000174697, Orphanet:66628, PharmGKB:PA228, VEuPathDB:HostDB:ENSG00000174697, eggNOG:ENOG502S5K5, GeneTree:ENSGT00390000011772, HOGENOM:CLU_132715_0_0_1, InParanoid:P41159, OMA:MRCGPLC, OrthoDB:1350528at2759, PhylomeDB:P41159, TreeFam:TF105086, PathwayCommons:P41159, Reactome:R-HSA-2586552, Reactome:R-HSA-381340, Reactome:R-HSA-381771, Reactome:R-HSA-422085, SignaLink:P41159, SIGNOR:P41159, BioGRID-ORCS:3952, EvolutionaryTrace:P41159, GeneWiki:Leptin, GenomeRNAi:3952, Pharos:P41159, PRO:PR:P41159, Proteomes:UP000005640, RNAct:P41159, Bgee:ENSG00000174697, ExpressionAtlas:P41159, Genevisible:P41159, GO:0005829, GO:0005576, GO:0005615, GO:0003677, GO:0005179, GO:1990460, GO:0051428, GO:1990051, GO:0060612, GO:0008343, GO:0001525, GO:0035904, GO:0008206, GO:0098868, GO:0035630, GO:0003300, GO:0032869, GO:0071298, GO:0044320, GO:0071300, GO:0021954, GO:0008203, GO:0007623, GO:0008340, GO:0042755, GO:0051541, GO:0006112, GO:0006635, GO:0007565, GO:0042593, GO:0006006, GO:0006114, GO:0042445, GO:0030073, GO:0050892, GO:0035556, GO:0033210, GO:0050901, GO:0006629, GO:0043066, GO:0032099, GO:0038108, GO:0010507, GO:0061037, GO:0070093, GO:0046325, GO:2000486, GO:0010888, GO:0000122, GO:0045906, GO:0001542, GO:0006909, GO:0001890, GO:0120162, GO:0048639, GO:1904651, GO:0046881, GO:2000491, GO:0046628, GO:0032735, GO:0032755, GO:0032757, GO:0043270, GO:0033686, GO:0043410, GO:1900745, GO:0035360, GO:0014068, GO:0042307, GO:0051897, GO:0001934, GO:2000379, GO:0046427, GO:0042102, GO:0032008, GO:0032760, GO:0042531, GO:0032310, GO:0045765, GO:0008217, GO:0046850, GO:0090335, GO:0051726, GO:1900015, GO:0001936, GO:0006111, GO:0050796, GO:0030300, GO:0060587, GO:0032814, GO:0042269, GO:0032817, GO:0050999, GO:0050810, GO:0014823, GO:0002021, GO:0032355, GO:0045471, GO:0001666, GO:0032868, GO:0033197, GO:0019953, GO:0030217, GO:0007260, Gene3D:1.20.1250.10, InterPro:IPR009079, InterPro:IPR000065, PANTHER:PTHR11724, Pfam:PF02024, PIRSF:PIRSF001837, PRINTS:PR00495, SUPFAM:SSF47266 |
| Sequence |
mhwgtlcgflwlwpylfyvqavpiqkvqddtktliktivtrindishtqsvsskqkvtgldfipglhpiltlskmdqtlavyqqiltsmpsrnviqisndlenlrdllhvlafskschlpwasgletldslggvleasgystevvalsrlqgslqdmlwqldlspgc |
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