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| Record Information |
| Record ID |
110 |
| Pubmed ID |
34040262 |
| SNP |
|
| Gene ID |
3569 |
| Protein ID |
P05231 |
| Vaccine Adverse Events |
Cytokine release syndrome |
| Vaccine |
Pfizer-BioNTech mRNA COVID-19 vaccine |
| Gene Name |
IL6 |
| Official Symbol |
interleukin 6 [Homo sapiens (human)] |
| Aliases |
BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6 |
| Other Designations |
interleukin-6; B-cell differentiation factor; B-cell stimulatory factor 2; CTL differentiation factor; hybridoma growth factor; interferon beta-2; interleukin BSF-2 |
| Chromosome |
7 |
| Location |
7p15.3 |
| Annotation |
Chromosome 7 NC_000007.14 (22727200..22731998) |
| MIM |
147620 |
| DNA Sequence |
>NC_000007.14:22727200-22731998 Homo sapiens chromosome 7, GRCh38.p14 Primary Assembly
ATTCTGCCCTCGAGCCCACCGGGAACGAAAGAGAAGCTCTATCTCCCCTCCAGGAGCCCAGCTATGAACT
CCTTCTCCACAAGTAAGTGCAGGAAATCCTTAGCCCTGGAACTGCCAGCGGCGGTCGAGCCCTGTGTGAG
GGAGGGGTGTGTGGCCCAGGGAGGGCTGGCGGGCGGCCAGCAGCAGAGGCAGGCTCCCAGCTGTGCTGTC
AGCTCACCCCTGCGCTCGCTCCCCTCCGGCACAGGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGC
TCCTGGTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCCGCCCC
ACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATCCTCGACGGCATCTCA
GCCCTGAGAAAGGAGGTGGGTAGGCTTGGCGATGGGGTTGAAGGGCCCGGTGCGCATGCGTTCCCCTTGC
CCCTGCGTGTGGCCGGGGGCTGCCTGCATTAGGAGGTCTTTGCTGGGTTCTAGAGCACTGTAGATTTGAG
GCCAACGGGGCCGACTAGACTGACTTCTGTATTTATCCTTTGCTGGTGTCAGGAAGTTCCTTTCCTTTCT
GGAAAATGCAGAATGGGTCTGAAATCCATGCCCACCTTTGGCATGAGCTGAGGGTTATTGCTTCTCAGGG
CTTCCTTTTCCCTTTCCAAAAAATTAGGTCTGTGAAGCTCCTTTTTGTCCCCCGGGCTTTGGAAGGACTA
GAAAAGTGCCACCTGAAAGGCATGTTCAGCTTCTCAGAGCAGTTGCAGTACTTTTTGGTTATGTAAACTC
AATGGCTAGGATTCCTCAAAGCCATTCCAGCTAAGATTCATACCTCAGAGCCCACCAAAGTGGCAAATCA
TAAATAGGTTAAAGCATCTCCCCACTTTCAATGCAAGGTATTTTGGTCCTGTTTGGTAGAAAGAAAAGAA
CACAGGAGGGGAGATTGGGAGCCCACACTCGAATTCTGGTTCTGCCAAACCAGCCTTGTGATCTTGGGTA
AATTCCCTACCACCTCTGGACTCCATCAGTAAAATTGGGCGTGGACTAGGTGATCTCATAGATCCTTCCT
GCTGGAACATTCTATGGCTTGAATTATATTCTCCTAATTATTGTCAAAATTGCTGTTATTAAGTATCTAC
TGTGTGCCAGGCACTTTAAATAAATATTGTGTCTAATCTTCAAAACAAATTTGCAAGGAAGGTTTTTGGA
GATAAGGAAACTGAGACTCAGGATTAAGTAACACACCTAAAGTCACAGGTGAGCTTGGAACTGAACCCAA
GTGTGCCCCCACTCCACTGGAATTTGCTTGCCAGGATGCCAATGAGTTGTAGCTTCATTTTTCTTAGAGA
CTTTCCTGGCTGTGGTTGAACAATGAAAAGGCCCTCTAGTGGTGTTTGTTTTAGGGACACTTAGGTGATA
ACAATTCTGGTATTCTTTCCCAGACATGTAACAAGAGTAACATGTGTGAAAGCAGCAAAGAGGCACTGGC
AGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGATGCTTCCAATCTGGATTCAATGAGGTA
CCAACTTGTCGCACTCACTTTTCACTATTCCTTAGGCAAAACTTCTCCCTCTTGCATGCAGTGCCTGTAT
ACATATAGATCCAGGCAGCAACAAAAAGTGGGTAAATGTAAAGAATGTTATGTAAATTTCATGAGGAGGC
CAACTTCAAGCTTTTTTAAAGGCAGTTTATTCTTGGACAGGTATGGCCAGAGATGGTGCCACTGTGGTGA
GATTTTAACAACTGTCAAATGTTTAAAACTCCCACAGGTTTAATTAGTTCATCCTGGGAAAGGTACTCTC
AGGGCCTTTTCCCTCTCTGGCTGCCCCTGGCAGGGTCCAGGTCTGCCCTCCCTCCCTGCCCAGCTCATTC
TCCACAGTGAGATAACCTGCACTGTCTTCTGATTATTTTATAAAAGGAGGTTCCAGCCCAGCATTAACAA
GGGCAAGAGTGCAGGAAGAACATCAAGGGGGACAATCAGAGAAGGATCCCCATTGCCACATTCTAGCATC
TGTTGGGCTTTGGATAAAACTAATTACATGGGGCCTCTGATTGTCCAGTTATTTAAAATGGTGCTGTCCA
ATGTCCCAAAACATGCTGCCTAAGAGGTACTTGAAGTTCTCTAGAGGAGCAGAGGGAAAAGATGTCGAAC
TGTGGCAATTTTAACTTTTCAAATTGATTCTATCTCCTGGCGATAACCAATTTTCCCACCATCTTTCCTC
TTAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTGGAGTTTGAGGTATACCTAGAGTACCTCCAG
AACAGATTTGAGAGTAGTGAGGAACAAGCCAGAGCTGTGCAGATGAGTACAAAAGTCCTGATCCAGTTCC
TGCAGAAAAAGGTGGGTGTGTCCTCATTCCCTCAACTTGGTGTGGGGGAAGACAGGCTCAAAGACAGTGT
CCTGGACAACTCAGGGATGCAATGCCACTTCCAAAAGAGAAGGCTACACGTAAACAAAAGAGTCTGAGAA
ATAGTTTCTGATTGTTATTGTTAAATCTTTTTTTGTTTGTTTGGTTGGTTGGCTCTCTTCTGCAAAGGAC
ATCAATAACTGTATTTTAAACTATATATTAACTGAGGTGGATTTTAACATCAATTTTTAATAGTGCAAGA
GATTTAAAACCAAAGGCGGGGGGGCGGGCAGAAAAAAGTGCATCCAACTCCAGCCAGTGATCCACAGAAA
CAAAGACCAAGGAGCACAAAATGATTTTAAGATTTTAGTCATTGCCAAGTGACATTCTTCTCACTGTGGT
TGTTTCAATTCTTTTTCCTACCTTTTACCAGAGAGTTAGTTCAGAGAAATGGTCAGAGACTCAAGGGTGG
AAAGAGGTACCAAAGGCTTTGGCCACCAGTAGCTGGCTATTCAGACAGCAGGGAGTAGACTTGCTGGCTA
GCATGTGGAGGAGCCAAAGCTCAATAAGAAGGGGCCTAGAATGAAACCCTTGGTGCTGATCCTGCCTCTG
CCATTTCTACTTAAGCCAGGGTTTCTCATATGTTAACATGCATGGGAATTCCCTGGGCATCTTCTTGTGG
TGTGGAGTCTGACTTAGCAAGCCTCGGGTGGGTTTGAGGGTCAAATTTCTACCAGGCTTATATCCCTGGT
GATGCTGCAGAATTCCAGGACCACACTTGGAGGTTTAAGGCCTTCCACAAGTTACTTATCCCATATGGTG
GGTCTATGGAAAGGTGTTTCCCAGTCCTCTTTACACCACCGGATCAGTGGTCTTTCAACAGATCCTAAAG
GGATGGTGAGAGGGAAACTGGAGAAAAGTATCAGATTTAGAGGCCACTGAAGAACCCATATTAAAATGCC
TTTAAGTATGGGCTCTTCATTCATATACTAAATATGAACTATGTGCCAGGCATTATTTCATATGACAGAA
TACAAACAAATAAGATAGTGATGCTGGTCAGGCTTGGTGGCTCATGCCTGTATTCCCTAAACTTTGGGAG
CCTAAGGTGAGAACTCCTTGAACTCCTAAGGCCAGGAGTTCAAGACCAGCCTGGATAACATAGCAAGACC
CCATCTCTACAAAAAACCAAAACCAAACAAACAAAAATGATAGTGGTGCTTCCCTCAGGATGCTTGTGGT
CTAATGGGAGACAGAACAGCAAAGGGATGATTAGAAGTTGGTTGCTGTGAGCCAGGCACAGTGCTGATAT
AATCCCAGCGCTATGGGAGGCTGAGGTGGGTGGATCATTTGAGGCCAGGAGTTTAAGACCAGCCTGGTCA
ACATGGTAAAACCCCATCTCTACTTAAAAATACAAAAAAGTTAGCCAGGCATGGTGGCATACACCTGTAA
CCCAGCTACTCAGGAGGCTGAGGCACATGAATCACTTGAACCCAGGAGGCAGAGGTTGCTGTGCACCACT
GCACTCCAGCCTGGGTGACAGAACGAGACCTTGACTCAAAAAAAAAAAAAAGAAGTTTGTTGCTATGGAA
GGGTCCTACTCAGAGCAGGCACCCCAGTTAATCTCATTCACCCCACATTTCACATTTGAACATCATCCCA
TAGCCCAGAGCATCCCTCCACTGCAAAGGATTTATTCAACATTTAAACAATCCTTTTTACTTTCATTTTC
CTTCAGGCAAAGAATCTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGC
TGCAGGCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAGTTCCT
GCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAGCATGGGCACCTCAGATTGTTGTTGTTAATGGGCATT
CCTTCTTCTGGTCAGAAACCTGTCCACTGGGCACAGAACTTATGTTGTTCTCTATGGAGAACTAAAAGTA
TGAGCGTTAGGACACTATTTTAATTATTTTTAATTTATTAATATTTAAATATGTGAAGCTGAGTTAATTT
ATGTAAGTCATATTTATATTTTTAAGAAGTACCACTTGAAACATTTTATGTATTAGTTTTGAAATAATAA
TGGAAAGTGGCTATGCAGTTTGAATATCCTTTGTTTCAGAGCCAGATCATTTCTTGGAAAGTGTAGGCTT
ACCTCAAATAAATGGCTAACTTATACATATTTTTAAAGAAATATTTATATTGTATTTATATAATGTATAA
ATGGTTTTTATACCAATAAATGGCATTTTAAAAAATTCA
|
| Protein Name |
IL6_HUMAN |
| Length |
212 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
13-AUG-1987 |
| Definition |
RecName: Full=Interleukin-6; Short=IL-6; AltName: Full=B-cell stimulatory factor 2; Short=BSF-2; AltName: Full=CTL differentiation factor; Short=CDF; AltName: Full=Hybridoma growth factor; AltName: Full=Interferon beta-2; Short=IFN-beta-2; Flags: Precursor |
| Primary Accession |
P05231 |
| Accession Version |
P05231.1 |
| Other SeqIDs |
sp|P05231.1|IL6_HUMAN,gi|124347 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Mar 15, 2005 this sequence version replaced gi:69690.; [FUNCTION] Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). {ECO:0000305|PubMed:30995492}.; [FUNCTION] IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (Probable). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity). {ECO:0000250|UniProtKB:P08505, ECO:0000305|PubMed:30995492}.; [FUNCTION] Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability (PubMed:17075861, PubMed:12794819). Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF (PubMed:12794819). Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (PubMed:20823453). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis (By similarity). Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (Probable). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (PubMed:15124018). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity). {ECO:0000250|UniProtKB:P08505, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:15124018, ECO:0000269|PubMed:17075861, ECO:0000269|PubMed:20823453, ECO:0000305|PubMed:30995492}.; [SUBUNIT] Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST (PubMed:12829785). Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling (PubMed:28265003). Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation (PubMed:28265003). May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling (PubMed:28265003). {ECO:0000269|PubMed:12829785, ECO:0000269|PubMed:28265003}.; [INTERACTION] P05231; P08887: IL6R; NbExp=7; IntAct=EBI-720533, EBI-299383; P05231; Q92673: SORL1; NbExp=4; IntAct=EBI-720533, EBI-1171329; P05231; Q99523: SORT1; NbExp=4; IntAct=EBI-720533, EBI-1057058.; [SUBCELLULAR LOCATION] Secreted {ECO:0000269|PubMed:11080265}.; [TISSUE SPECIFICITY] Produced by skeletal muscle. {ECO:0000269|PubMed:11080265}.; [INDUCTION] Plasma levels are highly increased upon exercise, due to enhanced production by contracting skeletal muscles. {ECO:0000269|PubMed:11080265}.; [PTM] N- and O-glycosylated. {ECO:0000269|PubMed:1883960}.; [POLYMORPHISM] Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture. {ECO:0000269|PubMed:11355017, ECO:0000269|PubMed:12768442}.; [DISEASE] Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. {ECO:0000269|PubMed:9769329}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; [DISEASE] Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. {ECO:0000269|PubMed:11001912}.; [SIMILARITY] Belongs to the IL-6 superfamily. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Interleukin-6 entry; URL='https://en.wikipedia.org/wiki/Interleukin_6'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/il6/'.; [WEB RESOURCE] Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL='http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL6'.; [WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL='http://atlasgeneticsoncology.org/Genes/IL6ID519ch7p15.html'. |
| Source Db |
UniProtKB: locus IL6_HUMAN, accession P05231;; class: standard.; extra accessions:Q9UCU2,Q9UCU3,Q9UCU4; created: Aug 13, 1987.; sequence updated: Aug 13, 1987.; annotation updated: Oct 12, 2022.; xrefs: X04430.1, CAA28026.1, M14584.1, AAA52728.1, X04602.1, CAA28268.1, Y00081.1, CAA68278.1, M18403.1, AAA52729.1, M29150.1, AAA59154.1, X04402.1, CAA27990.1, X04403.1, CAA27991.1, M54894.1, AAC41704.1, S56892.1, AAD13886.1, AF372214.2, AAK48987.1, BC015511.1, AAH15511.1, IVHUB2, NP_000591.1, XP_011513692.1, 1ALU_A, 1IL6_A, 1P9M_B, 2IL6_A, 4CNI_C, 4CNI_D, 4J4L_C, 4J4L_D, 4NI7_A, 4NI9_A, 4NI9_C, 4O9H_A, 4ZS7_A, 5FUC_A, 5FUC_B, 7NXZ; xrefs (non-sequence databases): CCDS:CCDS5375.1, PDBsum:1ALU, PDBsum:1IL6, PDBsum:1P9M, PDBsum:2IL6, PDBsum:4CNI, PDBsum:4J4L, PDBsum:4NI7, PDBsum:4NI9, PDBsum:4O9H, PDBsum:4ZS7, PDBsum:5FUC, PDBsum:7NXZ, AlphaFoldDB:P05231, SMR:P05231, BioGRID:109783, DIP:DIP-482N, IntAct:P05231, STRING:9606.ENSP00000385675, BindingDB:P05231, ChEMBL:CHEMBL1795129, DrugBank:DB05767, DrugBank:DB05513, DrugBank:DB11967, DrugBank:DB05744, DrugBank:DB12140, DrugBank:DB10770, DrugBank:DB10772, DrugBank:DB01404, DrugBank:DB13127, DrugBank:DB09221, DrugBank:DB09036, DrugBank:DB06083, DrugBank:DB05470, DrugBank:DB05017, DrugCentral:P05231, GlyGen:P05231, iPTMnet:P05231, MetOSite:P05231, PhosphoSitePlus:P05231, BioMuta:IL6, DMDM:124347, MassIVE:P05231, PaxDb:P05231, PeptideAtlas:P05231, PRIDE:P05231, ProteomicsDB:51828, ABCD:P05231, Antibodypedia:12025, CPTC:P05231, DNASU:3569, Ensembl:ENST00000258743.10, Ensembl:ENSP00000258743.5, Ensembl:ENSG00000136244.12, Ensembl:ENST00000404625.5, Ensembl:ENSP00000385675.1, GeneID:3569, KEGG:hsa:3569, MANE-Select:ENST00000258743.10, CTD:3569, DisGeNET:3569, GeneCards:IL6, HGNC:6018, HPA:ENSG00000136244, MalaCards:IL6, MIM:147620, MIM:148000, MIM:604302, neXtProt:NX_P05231, OpenTargets:ENSG00000136244, Orphanet:206, Orphanet:85414, PharmGKB:PA198, VEuPathDB:HostDB:ENSG00000136244, eggNOG:ENOG502S7Q4, GeneTree:ENSGT00390000000878, InParanoid:P05231, OMA:ENAKAMQ, PhylomeDB:P05231, TreeFam:TF335984, PathwayCommons:P05231, Reactome:R-HSA-1059683, Reactome:R-HSA-110056, Reactome:R-HSA-112411, Reactome:R-HSA-2559582, Reactome:R-HSA-381426, Reactome:R-HSA-6783783, Reactome:R-HSA-6785807, Reactome:R-HSA-8853884, Reactome:R-HSA-8957275, Reactome:R-HSA-9660821, Reactome:R-HSA-9662834, SignaLink:P05231, SIGNOR:P05231, BioGRID-ORCS:3569, ChiTaRS:IL6, EvolutionaryTrace:P05231, GeneWiki:Interleukin_6, GenomeRNAi:3569, Pharos:P05231, PRO:PR:P05231, Proteomes:UP000005640, RNAct:P05231, Bgee:ENSG00000136244, ExpressionAtlas:P05231, Genevisible:P05231, GO:0005788, GO:0005576, GO:0005615, GO:0005896, GO:0005125, GO:0008083, GO:0005138, GO:0006953, GO:0070301, GO:0071222, GO:0098586, GO:0019221, GO:0050829, GO:0050830, GO:0051607, GO:0031018, GO:0002314, GO:0070091, GO:0042593, GO:0002384, GO:0072574, GO:0006959, GO:0006954, GO:0070102, GO:0097421, GO:0035633, GO:0002548, GO:0043066, GO:0045779, GO:0008285, GO:0032682, GO:0032966, GO:0045599, GO:2000660, GO:0010888, GO:0050768, GO:2000635, GO:0070050, GO:0031175, GO:0001781, GO:0002446, GO:0030168, GO:0002675, GO:1902512, GO:0043065, GO:0050871, GO:0008284, GO:0032722, GO:1900017, GO:0051091, GO:0045893, GO:0010718, GO:0090091, GO:0010628, GO:0060252, GO:0002639, GO:0032731, GO:0032733, GO:0032740, GO:0032745, GO:0032755, GO:0032757, GO:1904996, GO:0002690, GO:0043410, GO:1903800, GO:0150078, GO:0045669, GO:0033138, GO:0050731, GO:1901731, GO:0046427, GO:1904894, GO:0048661, GO:0042102, GO:2000553, GO:0045944, GO:0045727, GO:0032760, GO:2000676, GO:0042531, GO:0010575, GO:0045765, GO:0061888, GO:0070092, GO:0050796, GO:1903978, GO:0150077, GO:0010574, GO:0014823, GO:0051384, GO:0032494, GO:0061470, GO:0072540, GO:0010573, DisProt:DP02745, Gene3D:1.20.1250.10, InterPro:IPR009079, InterPro:IPR003574, InterPro:IPR030474, InterPro:IPR030473, PANTHER:PTHR10511, PANTHER:PTHR10511:SF3, Pfam:PF00489, PIRSF:PIRSF001935, PRINTS:PR00433, SMART:SM00126, SUPFAM:SSF47266, PROSITE:PS00254 |
| Sequence |
mnsfstsafgpvafslglllvlpaafpapvppgedskdvaaphrqpltsseridkqiryildgisalrketcnksnmcesskealaennlnlpkmaekdgcfqsgfneetclvkiitgllefevyleylqnrfesseeqaravqmstkvliqflqkkaknldaittpdpttnaslltklqaqnqwlqdmtthlilrsfkeflqsslralrqm |
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