|
|
| Record Information |
| Record ID |
11 |
| Pubmed ID |
34835092 |
| SNP |
|
| Gene ID |
112744 |
| Protein ID |
Q96PD4 |
| Vaccine Adverse Events |
varicella vaccine meningitis |
| Vaccine |
varicella vaccination |
| Gene Name |
IL17F |
| Official Symbol |
interleukin 17F [Homo sapiens (human)] |
| Aliases |
CANDF6, IL-17F, IL17A, ML-1, ML1 |
| Other Designations |
interleukin-17F; cytokine ML-1 |
| Chromosome |
6 |
| Location |
6p12.2 |
| Annotation |
Chromosome 6 NC_000006.12 (52236681..52245689, complement) |
| MIM |
606496 |
| DNA Sequence |
>NC_000006.12:52236681-52245689 Homo sapiens chromosome 6, GRCh38.p14 Primary Assembly
TTTTTAAATTATTAATACTTTATTATATTAGCACTGAATATATTAATTTTTCTCCTAACATTTTAGATAT
CAAATATAAAGTGTAGTACATACACACATACATTGTGAATATTTTCTGTTTCCATCCGTGCAGGTCTTAT
TAAGAGTCCTGTGAAGTGGAGGGAATTGGGGGTCAGACAGGACTTGTTGCAGAGCACTGGGTAAGGAGTG
GCATTTCTACAGCTTCTTCAGCTGAGTGGATATGCACCTCTTACTGCACATGGTGGATGACAGGGGTGAC
GCAGGTGCAGCCAACAGTCACCAGCACCTTCTCCAACTGGAAAGAAACAGAGCAGCCTTGGTGCTTCCTC
CGGACGACCAGGGTCTCTTGCTGGATGGGAACGGAATTCATGGAGATGTCTTCCTTTCCTTGAGCATTGA
TGCAGCCCAAGTTCCTACACTGGGCCTGTACAACTTCCGAGGGGTACCGGTTGGGGTCCCAAGTGACACT
GCAGGAGGAGCAAGCCAAAGCACAATGGTGAGGCATGGGGGAGGAAGACAGCGAATGAGAGCCCCACAGC
ACTGAGTGTTCACCTGCAGGGAGGCAGTTCTGCAGGGCTGTGGCACAGGTTCTGGAGCCACACAGCCTGG
AAGCATACACCAGCCTCTGGCAGTGGCTTACCTTTCTAAGCCTCAGTTTCCTCAACTATAAGATGGGGAT
TTTCATATACCATTTTCTCATGCAACTGTTGAGAATACTCAGTGATACAAGTACATATAAAATACCCCAC
TGTACAAATGTTAGCATTCAATTAACATTAGATCTTTCATTGGCATTATTATTATTATTATTACAATTCT
TTATTCTCTGCCTGGAGATTGAACGTCACTAGTCAGTCTTCCATCACTAGTCGGTCTACAGAGCCTGCTG
CTTGGAAAGGAAAGCCACAGCCCCAGAGGTCTGTGAATCTCAGACCTTCTCTCCATTTCTCCTTTAATAG
GCCCCTCTGCCTGGAGGCATAAAGACCACAACATTTATCCTGCCAGCTTGCCATTGTACATATTCCACTT
GTAGTGTGACAGGACCCCCACCAGGTTACTTGAGGGTGTGTGTCCACTGTCTGAACCCTGAAGGACGGGC
AGTGAGCCAAGGCCACCATGCACAGCCAAGGAGCAGGCCACCGAGAACCCAAACATCTCAGAGAGTATCT
GAGAACCTACCAAGGAAAACAGTCCCATTGGACACACACAGTAGGCAAAGAGCCAGAAAATTCGCTTAAG
AGCAGCTTAGAGATGGGAGGCAGAGCGGATCTCTAGATCTGTCCTGCTGTGGCCCTAGGGCGCCCCATAG
TAAGTCTTAATAAACTCATCCACTCGCTAAGCTGGACTTGTCCAAGTCATTCTTTGATCTCTCCATATCT
TCCCAGTTCGAGGCAGGGGGCACTACCGTCCCAAGGTTTTCTCATAACACACTCACATGAGAAGCTATGT
GACAACCCCAGAAGCACTTCAATTGTCCCTGGAATCTACTTTGATACTTACATTTGGAGAGTATGAGGGA
GTGCTTGGTCTTCCAAGAACCTGTATCTTAATGCCAAATTACAAGACTGTACCCTGAAGGTCTCCACCTA
ACATCCCATTTCCCAGACTGGCCTTTCTCCTCCACTCATTCCCACTCCTTAAATGATAATGTCTAATCTG
AGTGAATCTCCTTAAACCGACTTTTCTGTTTCCCATTTATCCTCATGAGGAGATAATTATGCAATCTGCT
TTAAAGAACCCTCTCTTCCAACACAGGAAAATTTGTGAATTCTATCCTAGAACTACATGAAGCAGAAAAA
GGCACAAAGTCTATGAGAACGTGGAAGCAAAATATTAGGACCATCAACCACAAAGGTGAACCTAGTCCAA
AACAAGAAAGATATGAGCTCCCAGGTAAAGTGAAATTTTCATTGTTAAGAGGATTTTCCCTTTTATTTTT
TCTATGTATTCTACATTTTCTACTTTATGATTAGAATGAATTAACATATTTTTCCAAAGAATGTGAAAAT
CAGTCTCATTTGCACTTACGTGTAATTCCAGGGGGAGGTGGAGCGGCTCTCGATGTTACGTGACATGGAA
ACGCGCTGGTTTTCATTGATGATGCCAATGTCAAGCTTCATACTACCTCCTGGCACAGGCGGGCAACTCT
CAGGCTTTTGGAAAAAAGTATGTCCTACTTTGGGGATTTTCCGAGCTGCCGCCTCACTCAGAAAGGCAAG
CCCCAATATCGACAGCAGCAAGTACTTGACCTGGAAAATAGAAGACGCTGCAATCAGTTAGAGACTCGCC
TCACCTACTAGCAAGAGATGCATGGTCTGGCGGAACTCAGCATTCCTGTCCTTTTATGGGATCAGGGCTT
CTCTTTGCACCTCAGTTCCTCACCTGGAAATGGGAACACTCACACCTAAAGGTATCAAGGTGCCAAACTG
AGAACTAAACTCAGTAGCCTAGCTAGTAACTGAAGCCCTCCATAGTCTAAAAGCTCCCAAACAGTGAGAC
AGAAAGATGCAAGGGTCTGAGATTGAGTTAAAATCCTATCCTGGCTTCCTTGCTGAGCCTCTAGTTTCTC
TTCCTTCCAACTGGATAATAATGCTCACTTTATGAGACTACTAATGAGATTAAATAGAATGTTCTATATA
AAACACCTATAAATCTGTATAAGAAAAATAGAGGCTTAATAAACGATAGCTCTTGTTTTTATTTCCAACT
TGATATCCCATGAATCTCCCACAAAATCCTTCTTCGGAGCCACCCCTCTACCTAGAATACACTGCCTAGA
ATACTCTGTCTGTCAAAATCCTACCCTTCCATTAAGGCCCAGCTCAGATGTGATCTCCTCTAAGAACAGT
CCCTAAAATGGTTCAATCAGAAGCATGTTTATTATCCTTAAATTATAAAGCTTTGATCATCTAGCACTCA
AGCAGCATTTTTTAATTGTCTAGAAATGTAGTATTTGTGTTCCTGTCAGATCTACACCCATTAGATTGTA
AGTTCCTGCATATTACACATTTTCCATAAACACTTTTGGAATGAATGAGTGAATGAGTGAATGAATGAAC
AAAATGATACAGCTAAATTGAACTATATAGTTAAGCTCACTGCATTAAGAAAAACATTACGCAAAACCAA
CGATAGCAAAGTTCCAATTATCCATGCTAATTGAAAGAAACCGGGGCACTAATGATGCACCACAAGAGAG
AATATGGAAACTATTTCTCTTTAGCTCTGGAGCATTTTTTTTATACTTACGTTGAAATGCCAGTTTATCT
GGTGTTATAGGAATGCGCAAAGAATGAAAGTGCACTGAAGACCTAATGAAAAGAAAAGCTACAAATCTTG
CCAGATTCCCTTTGTCACAACCATGCTTTGCTCACCCACCATTGCCACTGACCCTTACTGGGGATGAGCA
AGGCCCATCACCAACTCTCAACATAATACAGAAGAAGAGCTGAAGGCCGGGTGCAGTGGCTCACGCCTGT
AATCCCAGCATTTTGGGAAGCCGAGGTGGGTGGATCACCTGAAGTCAGGAGTTCAGGACCAGCCTGGCCA
ACATGGTGAAACCTCGTCTCTACTAAAAATATAAAAATTAGCCAGGCGTGGTGGTGCACGCCTGCAATCC
CAGCTACTCGGGAGGCTGAGGCAGGAGAATCCTTTGAACCTAGGAGGTGGAGGTTGCAGTGAGCCGAAAT
TGCACCACTGCACTCCAGCCTGGGCGACAGTGCGAGACTCCTGCTTGGAAAAAAAAAAAAAAAAAAAAGA
GCTGAAAATAAGTTGCTTTTATTCTCTAGGCTTAGCGTTGTTCAGGCTCACACCTTCCATGAGTTAAGGT
AGGGAAGGTGATTAGACATGTTGGTTTCAAAGGCCTTCCTTTTCATATTTTGCAGATACTAGAGACAAAA
AACAATAAGAGTAAACAAAAAGGTCATAGTGTCCATTTGCCATACTGAGGAAGCTGACACTAAAAAGAAG
TTGAAAGCAAGATTGACCCAGAAGAGTCAGAATGAGGCTGATTTGCCTTTAGATAATCAGCAATCATCAA
CTTTCATCCCCCACAATCGTTCATTCATTCAACAACTAGCTCTTGACTTTACAGTGTGGTAGCTCAGGGC
ATGGGCTTCAGAGTCAGAAGTCCAGGGTCTGTAACTCAATTCCAGGACTCTTAGAAGCGATGACTCTGTT
TCCTCAAAAAAAAAAAAAATGTGAAGATTAAATGAGATGATCCATATAAATTATGAAGAACACTGGCAGC
ATATGATAAGTATCCAATACTGGCGACTCTTGCTAACTCTATATTGTGCTACACAGTGGACTAGACAGAT
GTGGAATTTACACTCATATACCTTGTCTTGACAAACTGCTATGGCGTTTGTTTGTTTGTTTGTTTGTTTG
TTTGTTTTGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTACAGTGGCACAATCTTGGTTTACTGCAAT
CTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTTCCGAGTAGCTGGGATTACATACGTGCGCC
ACCACACCTGATAATTTTTTGTATTTTTAGTAGATATAGGGTTTCATCATGTGGTCAGGCTGGTCTTGAA
CTCCTGACCTCAAGTGATCTGCCCACCTCGGCCTCCCAAAATGCTGGGATTACAGGCCTGAGCTACCGCG
CCTGGCCTGCTATGACTTTTTTTTTAAAAGATGCCAACTTATATTAGAGGGTCTTAGATAACTTCCCAAG
CCTACCAATCACATATTTAGGGTTCTTAAGTAAATTCCTCCTTTGTGTTTTCTCTTTCCTCTTCTGTGTC
ATACTCACTGAATCACTATTAATTTTCATTATGAAAACTTTTAAATACATACATTGGAGTTATATGACTT
AGCAATAATTACAATGCTTCTAACAAGTCATTATTACATTTGCTTATATATTCTTAGAGTATATTAGAAA
ATTCTTTTACATCTCTTTAAACACTGGATTTTCACAACTACCTGGTGAGGTAATCAGAGCTAGTATTAAT
TATCCCAATTAGACAGGTGAAAGAGTTCTGTCCCAGAGGGAATAAATAACTTGATTGGGTTCACCAGCCT
ATGAGTACCAGTCTGGGGACTCAAACCTAGGTGTCAGTAGTCAGTGCTATTGTCATTGAAGGTCATTTTT
ATTATTACCAACATTAATCTTAGTTTTGTCTCATTAGAAGAGCTAAGTGTTTTAGGTAATGTGACAGCTG
TACTAGATGTGCATAAGTGTTGTAGGTCACATAGCTCGTTATCAGGAAATCAGATGATGTCTGCAAATAC
TCCAATTTGCTCCACAAAGCTTTTGATCTGAAACTGTAGATTTTAGTGGTTATGTAATACAGAGCAGGGG
CTCTGAACCAGGCTGTTGCTGGTTCTTAAGAATGATTTAAACAGCACCTCTCAGAGAAATCCAGAGCATG
ACTTGAACTCTTATATGCCACCTATAAAGCAGATGAATAGATATCGCTCTCAATCTGTATAATAGGGGAC
AGGGGCAAGGGAAAGCACCAGGTGAAGGTGAGCTGTAACAGGACAACAACCTTCTCAGCCTAGCTTTGCA
CCTCACTCTAATGTGAGCTCACCTGAGCAACCTGAACATCCATCCTCTATACTCACCAGCAATGTGTGGA
CACATGTAAGCATGCACCTGGCCAACCTCTAGGTCCATGAGAATTTGCCTCAACTACTTATTGAAGATGT
CCTATCTGCCTGCACCTCTCAACTTCTAATCCTATTCCAATGCTCCTTGCACTGTTATGTTTCTTGCTGA
CAACCCAACAGATTTCTTTAAGGAAACTAGAATTAGAAATAGCTATGGAGCACAAAGCTACCCAACAGAA
TTGCTTGGATGCAATGGCTTTAAATTCACAAATCTTGCCTCTGAACCAAAGAAAAGCATACTGTATGTGG
AGACAGAAAGCTTAGATTGGTGTACCAGTTCTTGTGCTTACAGTATCCAGCAATGTTAAATAAATAGCTT
AATTGAGCTTTTGTTCATCTGTATAAAGTGGAAAGTATTCCCATCTACTTCAGTGGATTGATCAGAATTT
CCAGGACAATAATAACAATATTAATATGAACAGTTAACACTTACTGAATGCTTTCTCTATCATTATCAGT
CGTTGTTTATTAGAATGGCCAAATTAACTGAAAATTAAGCATACACAAATCTGCCAGTACAGAGTATAGA
CTCATTTATTCTCAAAGATATTAATTAATCCTCCCAATAAATGCCATGAGAAAGATGCCATTGTTATCCC
CACCATACAGTTGAGGAAACGGAGGCACAGAGAAGATAAATAACTTACCCAAAAATCCTACATTTAGCAA
GCAGTGGAGCCAGGTCTGCCTGACATCAAAGCCTATGCCCCTAAATATGGCACTTTGCTGAGCTACATGT
AATCTTTAAAATAACACATAAATATAAAATAAAACATACCATTGCTATATGCCATGAACCTTTTATGATA
TTCAAGCTCTTTTAAGTTGTATGGCTTGTAAAAGGAGAAAAAAAGGAAATTATCTAAGCCAATAATATGA
TGCGGGATTTCCTAACCCCTGTTTTCATGTACCTCTATAGTAAATTCTTCTCAGGCCTTATCTGACTAAT
GTCAGGCAAGATTCCAGACCTGCTGGGGCTAGATTTTCATTGCATTAACATCTCTCTTTCCTCCAAGAAG
AATGAGATGGTACAAAATAAATAAATAGCAATCAGAGACATGGGAAATTTCCCTTCTCTAGGAGCTGTCC
AAAGTCAACACTGGGTGATTTCATTTCTTCCATCCAGGGCACTCCTGTAATCTCAGGGGAATCATTAAAC
CTCTTGAGGCCCCAGTTTCCTTGGTTAAAATGTATATGTACATAATCCCTAAAGTGCTGGCCAAGCTCCC
ACCATGAGATAAGAATTTCAGGCCAACCTGACTCTATAATGGATGGCCACAGGAAAGAACATGCTAGTTG
TCTGTGATGCCAAGGACTGCACACACTAACACCACCTGGGCACACACTAACACCACCTGGGCAAAAGCCA
TTGGGTGAGGAGCTGCATTTTTTTTTCTTTGAGACAGAGTCTCGCTATGTCACCCAGGATGGAGTGCAGT
GGCGTGATCTTGGCTCATTGCAACCTCCGCCTCCCAGGTTCAAGCCATTCTCCTGCCTCAGCCTCCCGAG
TAGCTGGGATTACAGGCAACTGACCCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCAA
GTTAGTCAGGCTGGTCTCAAACCCCTGACCTCAAGTGATCCACCCACCTCAGCCTCTCAAAGTGCTGGGA
TTACAGGCGTGAGCCACCAGGCTCGACCTAATTTCTGTATTTTTAGTAGAGACCGGGTTTCGCTATGTTG
GTCAGGCTGGTCTCGAACTCCTGAACTCATGTGACCCGCCCGCCTTGGCCTCCTAAAGTGCTGGGATTAC
AGGCATGAGCCACCACGCCTGGCCAGGAGCTGCATTTTTATGCCATTATAACTTTTCTAGTTATTTTTTT
CTTTTTCTCCACCAGACAGGAGTCAAAATTAAAGTCATCTCTGTTTTTTAAGAAGTAATTCCAAAAAGAC
CCCAATCAAACCTAATTCCTTAGGATTCTGTTTTCTGAAATCCTAGGCATGACAGTCCTTAAACCAGAAT
GATTGCTGCTACTCACCATGGCTGGGCCATGCAGGGTCTTCACTGTCATGTTGCGCTGGTGGCTTACTTT
GTGCAGGAAGCTCTTTCTGTGAATGTATCTTCCTGTGTATGCCTGTGTTCTATCAATGAGAGTACCTGTT
AGTTTTATAGCAATCATTGCCCCTGTTTCGATTGACCTGCTTACTGTCTTTAAGTTGTGGTTGACCCGGA
GTTACTGACGAATGCAGGGGTTTTTTTTTTTATTCCATTTCCCGAAGGGGAACAAAAGGGGGACCCTAAA
GAAAGGGATGACAGGAAAAGGACCAAATTTTTCTTTCCTTCTACCCTACTTCCACCCCCATTGCCCACAA
ATCAGAGCAAAATTTTTAATTTACTACAGAGATGAACCAAGTTAGAAATTGTTGTCAAATCTTTTTTGTT
CTTCCACAAATTGCCAACACCCTTGTCACGGACCATATGTTCTACTTTCCAGTCACGCAATATGAATCGT
GATTTAAATGGGAGAAAACTCATCCTTAGAGGAGCCTTGGTACTAAACTATCTTTACCTCCATTTTATGA
ATGGGAAAACAAAACTAAAGAAATGAATGACATAAGTGAAAAATTCAGAAATGATATACCCTGGTAGTTT
TGTTATCTCCCTGAACTAATTATTTTTTAACCCCATGGTTAGACTCCTACTGGTGCTTAATAAATAATCA
CTATTCATTGTGTTGATAAAACAAACTGTTTTCCTCTGCTCTCACACCACAACCAGCAACACAAAAGATT
TCCATGACCATGTATGTGGGCATTTATCTCCATCAACCAGCAAGCAATCAATTCTGCATCCAACGCCAGC
TAAGCATCTTCTAATCCAATTCAATTCTGACGCTATCTCCAGGTAGGTAGAGTCAGATCCCACAGGCTGA
AGGCTCAGTCCCACAAAACTGCTCCCACTTTAAGCACCAATCACAGGTCCAAGCCTCTGGGACTTCTGAC
TGACTGGCCTCAAGTTCAGGTTCCCACAAACCGCTTGAGTTTGATTAGGCTTGATTAATTTGTTAGAACA
GCTCACAAAACTTAGGGAACACTAATTTATATTTACCAGTATATTCTAAAGGATATTTTTAAGGATACAA
GTCAACAGCCAGATGAAAAGGTACACAGGGCAAGGTTTGAAAGGGTCACAAGCACAGAAGTGTTCTTTCC
CATGGAGCTGGGGTGCACCACCCTCCCAGCACAGGGATGAGTTACTGTTTACCTTTCTTAGAACTTCCAC
AAGTTCAGCGGTCCAAAGGCTCTTTGTATCCCATCCTCTTGGGCCTTTT
|
| Protein Name |
IL17F_HUMAN |
| Length |
163 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
31-JAN-2002 |
| Definition |
RecName: Full=Interleukin-17F; Short=IL-17F; AltName: Full=Cytokine ML-1; Flags: Precursor |
| Primary Accession |
Q96PD4 |
| Accession Version |
Q96PD4.3 |
| Other SeqIDs |
sp|Q96PD4.3|IL17F_HUMAN,gi|239938888 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Jun 16, 2009 this sequence version replaced gi:74736710, Q96PD4.2.; [FUNCTION] Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:21350122). IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:18684971, PubMed:21350122, PubMed:11591732, PubMed:11591768, PubMed:17911633, PubMed:11574464, PubMed:28827714). IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (By similarity). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:32187518). Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (By similarity). {ECO:0000250|UniProtKB:Q7TNI7, ECO:0000269|PubMed:11574464, ECO:0000269|PubMed:11591732, ECO:0000269|PubMed:11591768, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:28827714, ECO:0000269|PubMed:32187518}.; [SUBUNIT] Homodimer; disulfide-linked (PubMed:19838198, PubMed:32187518). Heterodimer with IL17A (IL17A-IL17F) (PubMed:17355969). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule. IL17F homodimer forms predominantly complexes with IL17RC homodimer, whereas IL17A-IL17F favors complexes with IL17RA-IL17RC (PubMed:32187518, PubMed:28827714, PubMed:17911633, PubMed:18684971). IL17RA and IL17RC chains cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (PubMed:28827714). {ECO:0000269|PubMed:17355969, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:28827714, ECO:0000269|PubMed:32187518}.; [INTERACTION] Q96PD4; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-10292310, EBI-10172181.; [SUBCELLULAR LOCATION] Secreted {ECO:0000250|UniProtKB:Q7TNI7}.; [TISSUE SPECIFICITY] Expressed in T-helper 1 and T-helper 2 cells, basophils and mast cells. {ECO:0000269|PubMed:11591768}.; [DISEASE] Candidiasis, familial, 6 (CANDF6) [MIM:613956]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269|PubMed:21350122}. Note=The disease is caused by variants affecting the gene represented in this entry.; [SIMILARITY] Belongs to the IL-17 family. {ECO:0000305}.; [SEQUENCE CAUTION] Sequence=AAL14427.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Interleukin-17 entry; URL='https://en.wikipedia.org/wiki/Interleukin_17'. |
| Source Db |
UniProtKB: locus IL17F_HUMAN, accession Q96PD4;; class: standard.; extra accessions:Q6NSI0,Q7Z6P4,Q96PI8,Q9NUE6; created: Jan 31, 2002.; sequence updated: Jun 16, 2009.; annotation updated: Oct 12, 2022.; xrefs: AF384857.1, AAK83350.1, AL034343.17, BC070124.1, AAH70124.1, AF332389.1, AAL14427.1, NP_443104.1, XP_011512578.1, 1JPY_A, 1JPY_B, 1JPY_X, 1JPY_Y, 3JVF_A, 3JVF_B, 5N92_F, 5NAN_E, 5NAN_F, 6HG4_A, 6HG9_A, 6HGO_A, 6HGO_B, 6HGO_C, 6HGO_D, 6PPG_F, 6PPG_G; xrefs (non-sequence databases): CCDS:CCDS4938.1, PDBsum:1JPY, PDBsum:3JVF, PDBsum:5N92, PDBsum:5NAN, PDBsum:6HG4, PDBsum:6HG9, PDBsum:6HGO, PDBsum:6PPG, AlphaFoldDB:Q96PD4, SMR:Q96PD4, BioGRID:125201, IntAct:Q96PD4, STRING:9606.ENSP00000337432, BindingDB:Q96PD4, ChEMBL:CHEMBL4630880, GlyGen:Q96PD4, iPTMnet:Q96PD4, PhosphoSitePlus:Q96PD4, BioMuta:IL17F, DMDM:239938888, MassIVE:Q96PD4, PaxDb:Q96PD4, PeptideAtlas:Q96PD4, PRIDE:Q96PD4, ProteomicsDB:77668, ABCD:Q96PD4, Antibodypedia:30885, DNASU:112744, Ensembl:ENST00000336123.5, Ensembl:ENSP00000337432.4, Ensembl:ENSG00000112116.10, GeneID:112744, KEGG:hsa:112744, MANE-Select:ENST00000336123.5, UCSC:uc003pam.2, CTD:112744, DisGeNET:112744, GeneCards:IL17F, HGNC:16404, HPA:ENSG00000112116, MalaCards:IL17F, MIM:606496, MIM:613956, neXtProt:NX_Q96PD4, OpenTargets:ENSG00000112116, Orphanet:1334, PharmGKB:PA29800, VEuPathDB:HostDB:ENSG00000112116, eggNOG:ENOG502S5A0, GeneTree:ENSGT00940000156618, HOGENOM:CLU_118641_0_0_1, InParanoid:Q96PD4, OMA:DPHRFPT, OrthoDB:1469254at2759, PhylomeDB:Q96PD4, TreeFam:TF314701, PathwayCommons:Q96PD4, Reactome:R-HSA-448424, Reactome:R-HSA-6785807, Reactome:R-HSA-9705671, SignaLink:Q96PD4, BioGRID-ORCS:112744, EvolutionaryTrace:Q96PD4, GenomeRNAi:112744, Pharos:Q96PD4, PRO:PR:Q96PD4, Proteomes:UP000005640, RNAct:Q96PD4, Bgee:ENSG00000112116, Genevisible:Q96PD4, GO:0005576, GO:0005615, GO:0005125, GO:0019955, GO:0005126, GO:0046982, GO:0042803, GO:0002250, GO:0051216, GO:0050829, GO:0050830, GO:0006954, GO:0045087, GO:0097400, GO:0016525, GO:0002225, GO:2000340, GO:0001819, GO:1900017, GO:0032755, GO:0032761, GO:0045944, GO:0032645, GO:0032663, GO:0032675, GO:0032677, GO:0017015, Gene3D:2.10.90.10, InterPro:IPR029034, InterPro:IPR020440, InterPro:IPR010345, Pfam:PF06083, PRINTS:PR01932, SUPFAM:SSF57501 |
| Sequence |
mtvktlhgpamvkylllsilglaflseaaarkipkvghtffqkpescppvpggsmkldigiinenqrvsmsrniesrstspwnytvtwdpnrypsevvqaqcrnlgcinaqgkedismnsvpiqqetlvvrrkhqgcsvsfqlekvlvtvgctcvtpvihhvq |
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