|
|
| Record Information |
| Record ID |
109 |
| Pubmed ID |
34040262 |
| SNP |
|
| Gene ID |
3606 |
| Protein ID |
Q14116 |
| Vaccine Adverse Events |
Cytokine release syndrome |
| Vaccine |
Pfizer-BioNTech mRNA COVID-19 vaccine |
| Gene Name |
IL18 |
| Official Symbol |
interleukin 18 [Homo sapiens (human)] |
| Aliases |
IGIF, IL-18, IL-1g, IL1F4 |
| Other Designations |
interleukin-18; IFN-gamma-inducing factor; IL-1 gamma; iboctadekin; interleukin 18 (interferon-gamma-inducing factor); interleukin-1 gamma |
| Chromosome |
11 |
| Location |
11q23.1 |
| Annotation |
Chromosome 11 NC_000011.10 (112143260..112164094, complement) |
| MIM |
600953 |
| DNA Sequence |
>NC_000011.10:112143260-112164094 Homo sapiens chromosome 11, GRCh38.p14 Primary Assembly
TGAATTTTTTATTTGTTTATTTATTTATTTTATTTTTTGAGATGGAGTTTTGCTGTTGTTGCCCAGGCTA
GAGCGCAATGGTGCAATCTCGGCTCACCACAACCTCTACCTCCGGAGTGCAAGTGATTCTCCTGCCTCAG
CCTCTTGAGTAGCTGGGATTGAGGGCATGCGTCACTACACTCAGCTAATTTTTTGTATTTTTAGTAGAGA
TGAGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACACCTGACCTCTGGTGATCTGCCCGCCTCAGCCTC
CCAAAGGGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCATGAAATTTTAATAGCTAGTCTTCGTTTT
GAACAGTGAACATTATAGATCTATCCCCCAATTCATCCTCTTTTTTCAAAATGAGTTTAAAAAGGTCTCT
CTCTTTTTCACAAGCTAGAAAGTATCCTTCGTATGATGAAGATTCAAATTGCATCTTATTATCATGTCCT
GGGACACTTCTCTGAAAGAATATGATGTCACTTTTTGTATCCTTGATGTTATCAGGAGGATTCATTTCCT
ATAGAGAAAAAAACATTACCTAATTATTTCAGGACATGAACAATTTGAATATATGAAGTTTGTTTTGAAG
TATATTACCAAACAGAACAAAAGTAGTTTTGCTTCTCAAGAGTTACATAAAAAAAATCTCTGAACAGCAG
TACTGACCTCCTCTCCTTCTTAACTCCGAATCTCCTATTCTCCCTGTCATGGGATGCATATTCAGTTCCA
GGCCTCTAGTTTTCCCCTATACATCAAACAGCTTACTTCTCTCCTCTCCCATTGAGTGGTGTCCACATTT
GCTCAAGATTAAGTAGAGTTCCAGCAAAGACCACAAGCTTTTTGGGCTAATGTCAATTTCTGTCCTCTAT
AATAACCATTCACGGCTAAAGACGATGATGACCTCCTCCCACAAACTTAGGCTAGTTCTAGTTTCTTTTT
CTTTTTGCTTTGAGACAGGGTCTCGCTCTGTTGCCCAGCCAGAAGTGCAGTGGTGAAATCATAGCTCACT
GCAGCCTTGAATTCCTGGGCTCAAGCAATCCCCCTGCCTCAGCCTCCTGAGTAGCTGGGACTGTAAGTAT
ACACCACCACATTTGGCTAATTTTTAAAATTTATTTTTGTAGAGAAGGGGTCAGGGGGTATCTCACTTTG
TTGCCTAGGCTGGTCCTGAACTCCTGGCCTCAAGTGACCCTCCCACTTCGGCCTCCCAAAGTGCTGGGAT
TCCAGGTGTAAGCCACCATGCCTGGCCTGGCCAGTTCTCATTTCTGAGCCAACTGTGAGAGAGACAGAAA
GTGCCAGGAATCTTAGCTTACTCTTTCAGTGGAGCCTGAAATTAAAACTTACAGTGAATAGACCCAATAA
TTGTTGTAGGGCTAGGCCCTGGGTTCCTGTGTAAGCCTGCTGTATTGGCTCAGTTGGCAGTCCTTGACTC
TGTCTTCCTGCCAAGCACTCCAGTTCCATAGTAGTCTTGAATTTCTGTCCTGAATATGGTCTCCTTGGCT
GGGCCCTGCCTTAGAAGGCCAAATGCAGATTCTTGTATGTTTCAGTCACAGAATAGGGTCTTGTGAGAAA
TGGTTAGATTACTTGAAACTATAATCTTGCAGGTTATCCAACTGGTAGTGCTGCCTGCACTTTTCCTGTT
AGTGCAGCATGTCTATTTTGCAGGATGGATCAGAACATGTGGGCACCACCTAAGGTTCTTCCATGTTAAT
CCTGGAACCAGTAGATGTTTTGGACTTAATTTTGGCCTCATGGCAGCACAGATTCCCATGATCCTAAGCA
CTGATAGAGAAACCTCCAAAATTAAAATAGCATTTCTTCATCCTTCAAAGAGCCTGAAAGACTCTGGATG
GCAGAGGTCACGGGGTTACCTCCAACTTCTCAATCAGTTGTGGAATCAGTAGTCATAACTCTTGACCTTT
GTTCTTTATCAACAAGTGTGGGTCCTAAGTTGATGAAAGTATAAACTAGTTCCCCTATTGGCACCCACTT
CTGCAGCTGTCTACAATATACAATTTAGGAAGAGACCCTAAGCTGTGGGCATCAATTTGGAACTAATCTG
AAATCTAATGTATAAATGAGAAATAATCCATAGCCAAAACTTCAAAAGCTCTAGTAACATTACAGGGGAA
GATGAACCAGTATAGAAAGTTACAGTTGAGCCGGGTGCGATGGCTCACGCCTGTAATCCCAGCACTTTGG
GAGGCTGAGGCGGGCGGATCACAAGTTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTC
TCTACTAAAAATACAAAAAATTAGCTGGGCATGGTGGCAGGCGCCTGTAGTCCCAGCTGCTTGGGAGGGT
GAGGCAGGAGAATGGCGTGAACCCGGGAGGCAGAGCTTGCAGTGAGCTGAGATCGTGCCACTGCACTCTA
GCCTGGGCGACAGAGCGAGACTCCGTTTCAAAAAAAAAGAAAAAAAGAAAAAAAGAAAAAAAGAAAGTTA
CAGTTGAAAGCGAGAGTGTGGATAGGTAGAACAGGCAATCTCTTTAATCACACTTATTGCACATTTCAGA
ATAGAGGTAAGGACATCCTTGGGCAGTAGCTTTCCTAGTTTTGATGTTGACCACTCCCAGCCATCATAGG
GAAGGTACATAGCAAATGGATGTGAAAGCAATCCCAATGACCTTGGAGAACCCCCAACTTGGAAAGCCCT
ACCTGGTGAAACTTGAGTGCTCCAAGGGGAAAGGGATTTCTTTCTTTTTTTTTTTTTTTTTTTTACATCA
GAAGGGGTTGAATCTGAATCCAGGGAAAGTTGATATTGACCTAACATCTCCCAAGTGCACTGGAAAGTCT
GAGGGAACCCTGGCCAAGCCTGGATATAGATACATATATACATGTATATGTATATATATGAAACAGACAC
TGACAGTAACCTCTCAAAGCAAATCCCTCTTAGTGTTGTCAAGGTTCTTGACCAAAGAACTTTATAGGAC
TTTATAGCTAGTAATCAACAGTGAAAGGTGAGCACATAAGGGTAGCCTGTTGTATCTTTTTCTTTTTTTG
AGACAAAGTCTCATTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACTGCAGCCTACACC
TCCTGGTTTCAAGCGATTCTTCTGCCTCAGGCTCACGAGTAGCTGGGATTACAGGTGCATGCCACCATGC
CTGGCTAATTTTTGTATTTTTTTTAGTAGAGACAGAGTATCGCCATGCTGGCCAGGCTGGTCTTGAACTC
CTGATCTCAAGTGAGACACTCGCCTTGCCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACTGTGCCT
GGCCTGTTGTATCTTATTATCTAGAACCTAGGCCACTTTTATAACCACTGCTAAGATCCTTATTAGTGGC
AGGAAAAGGGATTAAAGACAAGGGCTAAAACTGGTCCTAGTCCACCCCTCACTCTCTCCCCCCCTCCAAC
TAATATTTATTGAGTTCCTTCCAGAAGCAGATTTGCTATGATGCTGATGAAGCTTAAATGTCAGATTCCC
TCATTTGCACAGATCTCTTCCAGCCACCCCCCGCCCTTTTTAAAATTTGAATTAAAATTTGAATTAAATT
ATTAAGCTTATGCCTTTGGTAATTTTACTTTTTTTTTTTTTTTTTTTTGAGACCGAGTTTTGCTCTTGTT
GCCCAGGCTGGAGTGCAATGGCACGATCTAGGCTCATCGCAACCTCTGCCTCCCGGGTTCAAAAGATTCT
CCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATATGCCACCACGCCCAGCTAATTTTGTATTTTT
AGTAGAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTTGAACTCCTGACTTCAGGTGATCCGCCCCCC
TCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCAGCCACATTCTTTTTCTTTAAAAG
GGCCATCAAAATTGAATAAACTTCAGGCTCCCCCAAATATGGATTTGCCCAGTTCCTACTAAGTGCCAAG
CATTATTTCCATCTTCTTAACATTTTCACCAGTCTCCCTCAACAAGAATCCACCTGTAGGTTCGGACTTA
TCCCAGTTTCTGAATCTGCCTCTGCAGCTGAGTTTTCCTCTATCCCACATAGCTTGAGCTTGGCCATCTC
CTTCCCTTCTAATTATGTTGTTCAGTAACAGCATGCTTAACCCTTTCCACCCTACCCTTCCATCCCAGGC
CTCTTATGCTATTTTGATAACTAAGCTGCCTGTCAGGTCTAGAATGGGGACTCCAAATTGTCACCTGAAG
GGGTGGCACTCTGGTTGGAGGGAGATAGCTGAGGGATTTGTCTGGGGGCTGTATCTGTTGCATATGCACT
GTTCTTACTTGGATTATATTTTAGAGTGGCTTTTTTCTCCCTACCAAGTTGCCCCTTGGTACCTTCACTA
AGGTCATATCCTAACTGTCTTTCAGTGGGGACTGGGTGGGCATGAAAGCGGTTATTTATTGGCAAATCTC
CACTCAAAAAGAGTCTTCATGACATGGAATTCTCCTCTGAAGCATTGCCAATTTGTAAGCATCCCTGGCT
ACTCTTACTGGCTCAGTCTGTAGCTATAGTTAATTGTGGTTTATCTAACAATAATGGAGGAAATAGAGAA
AAATAATAGAGAATAATAATGGAGAATAATAGAGAAAAAGTAGAGGCCAGAAATACTTTATACCTGGCTT
GAAGATAATTATAGCATTACTTTTACAGCTGATCTCATAACTTTTATTCAATTAGATTAACATTAAAAAT
AACATACATCAACTGGAAGCTGAAGCTTGTGTCTAAGACTTAGGCTAAGGATCAGCAACAAAACAACTAG
GGATTAAAATATTATCATAATTTACAAAGGTGTAGAAATATAGAAGGATAATTAGCTTCATTCTTCATAG
CAGAACTCATTCTGGAAAGTCACATGTTATTCTTAAATGTATAACTCACATATGTATTCTACATTATTAT
TTGTATAAAGACTGATTGTTCAGGAGATGCAGGTCATAAAACAAGTGTTGTATCTCCTCTTCCCTGTGAC
AGGCTCAGAAAAACCATCATTATCACAATAGGTAAAGAGTTTGATAATTTTTAGTAAGTATTCATTTTAA
TGGTTCTCTGCTTCTTGTTATTTCTGTTCTAGACAAAAGGTTGGTCTGAGGATATTTGAGTTTTCTAATT
ACATTACTTATATTAACATTAGAAATAATGTTATATTTCTAATTATATTAATTATATTAACATGATTGAA
AACAAAGTAAGGCTCAGTCTTACCTTAAAGGAAATAATTTTGTTCTCACAGGAGAGAGTTGAAATTTTCT
CACACTTCACAGAGATAGTTACAGCCATACCTCTAGGCTGGCTATCTTTATACATACTTATAATAAATAT
GGTCCGGGGTGCATTATCTGAAATAAATATAATAAATGAGAACTCTAGTTAGAAGAATTCTTGCACAGGA
ACATTTGCGGAAATTTAACCAAAGGATAGTCCTTAATACACCTGTTCCCACTTTGAGACTTGGCCAGTCT
GCAGGAGACTATGTACAGCTGGTCAGACATTTTTAAAAACACAGTTCAGGCCTGGCACAGTGGCTCATGC
CTGTAATCCCAGCATTTAAAAGTTAAAAACAACCTTTTATAATCTATATCATTATACTCATAAAAGTTGC
AGCATGTGTGTTGTAACACATATTAAACTGTGGGGTTGTTTGTTTGTTTGGGAGGCTGAGGCAGGCAGAT
CACTTGAGGTTAGGGGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCAGCTCTACTAAAAATACAAA
AATTAGCCGGGTGTAAGTGGTGCATGCCTGTAATCCCACCTACTCGGGAGACTGAGGCATGAGAATCGCT
TGAACGTGGGAGGTGGAGGTTGTAGTGAGCCGAGATCACACCACTGCACTGCACTGCACTTCAGCCTGGG
TGACAGAGTGAAACTGCATCTCAAACAAACAAACAACCCCACAGTTTAATGTGTATTACAACACACACGC
TGCAACTTTTTTGAGTATTTTAAAGATATGAATTCTAAAAGATTGTTTTTAACTTTTAAATGCTAAATAA
AATATTTAAAATATATGTTAAGGTAAGTATTCAGTATTTTTAAAGAATGCACATTCACTGCTTCAACTCA
GCCTAACTTTGATATTTGGAATTCATATTTTGGAAGGCACAGTAGACTTGATCATTTTCTTTTCTTAAGT
TTTTTTTTTTTTTTTTTTTTTTTTAATTTTAGAGACAAGGTCTGTATATCACCCAGGCTGGAGTGCAGTG
GCTATTCACAGGTACGATCACAGTGTACTACAGCCTCAAAGTCCTGGCCTCAAGCAATCCTCCTGCTTGA
GCCTCCCAAGTAGCTAGGATTACAGATAGATGCCACCACACCTGGTAAACTATCAGCATTTTCAGCTGTA
ACAAGCAGGGATTAAGCATCCAACTATAGAGGTTTTAAACAGTTAATGCAATCACAATAAAGGGATTGGT
GATTCAAAGGCAGGCTCAGAGAGGCATGACCCCTAGCAATGTCTTATTGTATCCAATTTTTTACCCCAAC
TAAAAAACGTGGATGCCTTATAAAGTTTCCTGTAAGTGAAATTATTGTCACTCCTGTGACTTTTCATCTG
AGGATTGGGACTAGCACGGAACAATGTAAGCAGTAAAACAGAATGGGAAGAAGTAGCTAGTCATTTCTAT
GTTTGCGAATTAAAAAAAATACCTCTACAGTCAGAATCAGTCATATCTTCAAATAGAGGCCGATTTCCTT
GGTCAATGAAGAGAACTTGGTCATTCAAATTTCTTATGACTGATAATTTAGATTCAAGCTTGCCAAAGTA
ATCTGATTCCAGGTTTTCTACAATAAACATTAAATCTCATTTAAAAATACATAGTTTCTTTGTTAATTGA
CAAATAAGTATGCTATATATTTTAGTTTTCTAAAACTATTAATGACAATCTTCTGTTCCAGAAGTAGCTA
CAATAAAGTTGCCTATTGTTTTTTAACCTACTCTCAAAGGCACACTCAATTTCTTGTTACCATTCAGAAC
TACTCTGCCTCTGAAGTGTTAACTTCAAATAGCCTACTTTCTGACCGGTCTCTTACCCTTCTAGTTTTCT
TACACTTTTACTCCAACTCTATGTGTTCTTAAATTTCACAACATCTTCCAGTCTCCTGACTCTTGTATTT
CCTATCTAACCTCTTCCCGTCTTCCCTTCCTTCCCTGTGCAGCTGGATCTCAGAGTTCATTTTGTCTACC
ATTTTGCCAGGATATTAAATCCCTAACTTATTTGTCTTTCTGCTACAAAACTCCAAACTTGGCTGCTGAG
TGCTGCTGGTGAACAATGGCACAAGCGTTCAAATCGGTGCCATTACAAGCATACCAATTGTCAATACTTC
TTTTGTTTTCCAGTTCAGCACTCTCTTCCATAGCTGATAGCCGCAATTTCAAATTTTCTTTGCTCTCTTC
AGGACCTCTACACCATCATCTCTGTTTTCATTTTCAGCAAATGATTTCCTGCTACTCCACGTACAAATTT
AACTCTGGCAGCACCAGTTATTGCCTCTCTCCCTTTTGTCCCAAGGGGAAATGAGAAAGTGCCATTTCTG
GTATCTAGGGCTGATCCCATTTGTGCTCGGCATGTACCCTCTACTGAAGCTTTAATTTGCCAATCATCCT
TTCTCTTCTATCAACCCAGCAATTCTACCTCCTGGGTTTTATCCTGAAGAAAAAATCAGACAAATGTGTG
AACATTTTTGTACAGGAATGCTTATGGGAACATTGTTAATAACAACAACAAACTGGAAACAAACATTCAC
CAATTAAGAATTGATTAAATAAAAAGGGCAAAGATATGCCCTTATTGTGAAATATCATGAACTTAATATA
ACTGCAATTACTCGTTGCCATGGAGAGATGTCCATATATATCACTAACTAGAAAAAGCAGCTTAGGTATA
GTACAATCCCTTTTAATAAAAATATAAGCATTTCTGTGTCTGTATATATACATAGAAAGGAGTGTAGAAA
TATTGTATCAAAATGGTAGCTATCATTATTTCTGGGTGGTTTTTATATTTTTATCTTTCATATTATTATC
TTTTTTCATTGCCTCAATTAGTTACAATTAACACATTATTTTCATAATCAAAAAAGCACAAAGCTCTTTA
TTTTGAGATTTAAAACTGCTCCATCAACCCAATCTCACTTTGCAGCTAGTCTTGTTTCTCTCCTCCTTTT
AACAGCCAAGCTTTTAGCAAGAATTATCTGTATCATTTCTTCACTTTCCATTCACTGTTTCACTCATTGC
AATCTGCCTCTGCCTCCATTTCACCATCAAGCTGCTTTCACTGAGATCACCAAACTCCTTGTTGCTAAAT
CTAAAAGCTGTGTTCTGGCCCTTGATTCTCAAGGCTGCAAAATTCAACACAACACCTATCCCCTCAATCT
TGAAATGCTCTCCTGGGAGTCGGTGGAATTCTCTTGGTTTTTCTTCTTCCCTTTTGGTTAGTCTGCTCTC
TGTTGTTTATTAGCTTCTTTCTACTGCATCCTTTAAATGTAGGTATTCCCCCCAGTTCAGTACTTGGCTT
TTCCTCTCTCACTTTACACATTTCCTCTGATTTGTCTTTTTATCTCTATAGATTCAAATGCCATTTCTAT
GCATAAGCCTTCAATATCTCTATCTCCAGCCCAAATCTTTGTCCTGAACTCAGAACCACATGTAGAAGAG
TTTTTGGACATCTCCACTAGGACGTTCCACAGACATCTCAGATCCAAAACGAAATGCGTCATCCATCCTC
CTCTTTGTATACACCAAAACCTGCTCTTCCTCCTGTGTTTCCTATTTCACTGAATGGTACAAATTGCCTA
AGTGAAAAATGTAGGCATCATCTTTTCTACTTTCTTCTCCTTTCCAAATCCAACCCTAAATCATGTCCTA
TTGATTCTCTCAAGTGTTTCTAAAATCCATTCACAGCTCCTCATCAGCACTCCCCTATGTCTACCTTAAT
TCATGACACCATCATTTCTTGTAATAACTAAAATAATAGCCTCTCAACCCTTAATTTTGTCCTCCTCACC
CCACACCATCAATTCTTTATACCAAAGCCAGAATGATATTTTAAAAATATATTATTTCTGAATTTTAAAG
AGTCATATGGCTACCTGGAATAAAGATTATATTTTCCAGATTTCCTTGCACTTGGTGTGGCCATGTGATT
AAATTCTAGTCAATGGAATATGAGGGGGATTGATGTGTTTAACTTCCAATTAGAGTCTTTGAAAGGAATG
AGCCTGACTTCTCTTGACCCTTTCTTGATAACTGGGATATGAACCCAGGAAGTATGATGATTTTCAACTA
TGTGAGTGAGATCAACAACTAGGGGATGATGGGTACAAGACTGAAGAAAGTTGGGGGTCCCAATATCATC
AGGTTGCTTCCAGCCATACTACTTCTGAGCTGCCTACTTAGACTTTCTTTGAGAGAAAAATTCTCTATCT
TATTCAGCTACTGTATCTTTGGATGTCTTTGTTACAACAAACTAATCTTTACCCTAGCTAATACATATTG
TGCTTAATTAACCCTATTATCTCCAAGATAAAGTCCAAATTTCACATCTTGGGGTGAGAGAACGTCTTGC
TCTACACCCTGTTTATCACTCTAGCTTCTCTCACCAGTCTCCTACTCCTACTCTACTTCCATTCTGAATT
ACCCTGAATTCATCATAAATGCCATGGTTTCTTTCAGCTTTTGGCCTCTGAATGTGGTCTTCTTGCCCCA
CCCATTCCTATCTCCTCTACTTCCAGAATTTTCTGCCCCACCCCACCACCAACCCGGGAACCTTCCAGGC
TTCTTCCCAAAGCATTTCTGAGAGGAGGTGTTACTGATTTTGGACAATTCTAATGCTTCAATCCCTTTTT
CCTATGCAACGCTCCCCCTACAACAGAATCCATGACTTCATGCTAATCTTAGGACCTATGAAACAGGCAA
AGTCTATTTTGTAGATTCTAAGAGCTGGAGAATTTTTTAAGGCATAGAGAAGCATCTTTTGCTAGAGGTT
CTTCTTTGTATCTCTTATGATCATCTTCATTCCAAAGCTGTGCTACTGAGTCCACATTTCTTTGAAGGCA
GATTGGTAGCATGAGAACCATTTTTTTTTTTCCTCAGCTGACAATGGTGAGATAGATGTGTCTCAAGCAG
ATACTTAGTTTGCAAAGAAAAATAAATTCATTTCTACTTTACCATCATCTTCAGCTAAGAGGGGGAAAAA
GAGAGAAACAGAATATGTAAAATTTTGTATTTCGACTCAGAATTCAATCTCATTCTAGCTTTTACTTTTG
CTACTCCTCTTTCTCGAACTCCTATTTTTATGGTTTAAGGGTCTGTCTTGGCTTTCATCAGAATATTATA
TAATCATCCAAAAGGCCCATAAAATGAAGCTTATCAGACTTAGTGTGTTCTCAGGTAATTTAGACATAAA
ACTTAAACCTAGGGTTTAAAAATTTCAATATGTAACTAAAAATAAATTTTATAAAATTAGAGATTTTACT
TTTAAATTTATTGCTTAAACGGAAAGTCACCTAAGAAAAGTCAACTAATAATTTTTTATGAAGGTTTTTT
TTTGTGTGTGTGTGTCAGGGTCTACTGTCATGCAGGCTGGAGTGTAGGGGTGGGATCATAGCTCACTGCA
GGCTCAAATTCCTAGGCTCAAGTGATCCTCCTGCTTCAGCCTCCAAAGAAGGTAGGAGGTGTCCACAGGA
TATTTTGCAGTTTTTTGTAGAGATGGGGTCTCACTTTGTTGCTCAGGCTTTTAAATGAAGGTTTCAAATG
AAGGCAAACTTTCAAATGAAGCCAAATTGTTCACAGAAGATTAATCATAAGAATCAATTTTTAGGCCATG
TGTGGTGGTTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGAGGATCATCTGAGATCAGGAG
TTCAAGACCAGCCTGGACAACATGGCAAAACCCTGTCTCTAGTAAAAATACAAAAAATTAGCCAGGCATG
GTGGGATGCACCTGTAGTCCCAGCTACTCAGAAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGTGG
AGGTTGCAGTGAGCAGAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAAAAAAAAAAAAAAGAATCA
ATTTTTACTTGTCAAACATATTTACATAAAATGGTGTAATTCACAGAACTCTAAATTTAGAGAATCTCTT
ACATAATTTGCCAATTTGCTTTGGGAAATTGTATTTCCTGAATGCACCCAGTTTTGTACTGGGATTTTTC
CCATGGAAATCCAATGAAAACTGGGATTTTCCCATGAAAACTGGGATTTTCATGATGTGCACTTACTGCC
AACTGGAGAGTGAGCTACTGCTGATTAAAGTGCCAGGACACGTGGTGTGACAAGGTGCTGAGACCTTGGA
CATGTTGTGGTTAATTTCTAGAGGTCCACTATTTTTTTAAGAGCCATTAATATTACAGTGAAATTTGGTG
ACAAAAAGAGTCACTTAATAGTTCACCTCACAACATCTTTTCTAATTGAATAGATTTATCTGAACCTGGT
ATTTGTTCTATGGCATTAGCCTTACCTATAAAGTAAAGCGTATTGTCAATAAATTTCATTGCCACAAAGT
TGATGCAATTGTCTTCTACTGGTTCAGCAGCCATCTTTATTCCTAATGAAAGCAAAGAGCCATCTGTTAA
GAGACAATGATTGTACCTTTTACTACTACTTTATACTACCTTCAAGTTCAGTGGTCAGTTAATCACCTAG
TATACTGATGAACAATCTTGACATTCAATAAATGCCAGAAGTTTCAGCTTATGAATACCCATGTTTAAGT
GTTCTCTTACAAATCATCAGATATTTGGAAGATAGAAAGCATTTTCTCATTAAACAATATTATAAAGGGT
AGATAAATGGCCTAGTACTGAACTGAATCATTATTCTAGTATTCCTTGAGAAATATAAATATATTGTCAA
TATAAATATAGTTTCACCTGAGGATGCCATAAACACATCTAATCGTGCCCTTTAGGAAGGACTGGCTTCA
TCCTTCTCTTACAACCAGTGGGTTCCTATGGGTGAGAGGCTGAAGGTTTGTGACTTCATTGTCAAAATGC
TAAAGGTGAAACAATGATAAAAAAGTGCTTCCATCTGAGGGTACAGGCAGGGTGGGAGAAGGCTGAAGGG
CTCTGGCATTTGGTGGCCCTCTTTCTCCCTGAGCTGCGGTGATTTTTGATCTGGAGTCTCGATTATACTA
TATTTTTAACACAAGTAATACATAAATACAATCTTGCTGTAAAATCAAGGGATACAGGATTTGAAAAAAA
TTTAAATCCTTCCATTTGCTTTTCCTTTCTGCCCCTCTTCCAATACGGTGTGCAGGCTTCCAGAATTTTG
TTATGGAATAGGAGTTCTCAGTGTGAGAAATCTGTGAACTTGGATGGGGAAAAAAATACACATGTATTTT
CACCAACCTCTGAAATTTAGCATTCCTCCCATGATTAGTTGCAGGAAACAAACCACAGTATTATTAGTAG
TACTTGTGACTCTGTCATTAATAGAAATACCTATTTTCTGTTGTGCTACAATTATTGCAGAGATCTTGAG
ACATGGTTTAAACTCATTACTACTTTGAAATTACAGAAGTTTAGTCCTCACAGTAGATCTTATTATTTAA
TGTGTTGGTAAAAAGGCACATATATACTGCATTAAAATTTGTTTAAAAATTAAATGGTATGCAGGAGAGT
ATTCATAAATCTGTGCTCAAAATTTTTCTAGCATAATATGAGGCCTAGCATGTATGGTAGAGTAAGCAGG
AATTTAAAACTCAGTTTAAAAAAAATTAATCTGAATTAAGCTAACCCCAAAATAGTTGTTAGTTGGTGTT
ATACAACTAACTTTGTATAATTTTGGCCTCCCAAAGTGCTTGAGATTACAGGCATGAGTCACTGTACCCA
GGCCTTATTTGATAGTTTTATCTAGGTTTAGTTCCTTATGCTCATCTAAGTGCGAACAGTTATTAAATTT
ATCTTATTTAGATAACATTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCACCCAGGTTGGAGTGCAGTG
GCACGATCTCAGCTCACTGCAACATCCACCCCACCCCTCTCACCTGGGTTCAAGCGATTCTCCCATCTTA
GCCTGGGACTCCCATCTGGGACCACAGATGCGTGCCACCACACCCAGATAAGTTTTCATATGTTTGGTAG
AGACAGGGTTTCACCACGTTGCCCAGGGTGGTCTCAAACTCCTGAGCTCAAATGGTTTGCCTGACTTGGC
CTCTCAAAGTTCTGGGATTATAGGTGTCAGCCACCATGCCTGGCCAACACATTTAAATAAAATAAAAACT
GATGTACAAATGAATTTAAATAAACATTTAAATATTATAAAATTTAAATATTTATCAAACATTTAAATAT
TATAAATATTAAATTTTATAAGCTATTTATAATATTTAAATTTACAATTTAGAATTATCACCTAGTTTTT
TAAAGGAGGGGATAAGGAAGACTCTTAGAGAAAAATAATATAGCAAAGGATGAAAAGATCACTAAGATAA
GTCTAAACATTTTTCACCAAAACCCAAACCAACATTAATATTAAAAATCAGAACAATAATGACTAGGCTG
TGAGCTCCACGAGGGCATGTTCTTTATTCACCTTTATGGCTTCATTGCTGAACAAGGCCCTATTATCAGC
ATCAGAAGGTGTTTGTTAATGACTGCATTAACTGAGAAGGCAGACATTTGTTAACCTGAGAGGCACTCTA
TGTTTTGATTAGTTATCAGTTGGTGAAATAATGATTAGCATGATCTTCTGTACATACTTTAATATTATGT
AATACACACATATTTATCAAACTAATTCACCTGAAATGTACCAAGCAGTATGGGCAGGAATTGGATTAAA
TTACTGGTGTTTACTATTTTGAGTACATAGTTAGTCAATGAGTGAATGGATTTAGAGAAGGACAATATTT
GAGCTGATTCACCAGTTAAGGTTTGAGCATTAACTATGCATCAGGAATGTGGCCAGTAGCTGACCAAACC
ACACATGAATGAGAGTTGGCTCCTACTCTCCAGTGACTCAGAGTCTAGTGGGAGAGAAGAATCTATAAAG
AGTTACAAAATAATGTAATGAATGACGTAAGAGCTGAATTTACAAGAGATTCATTCTTTCTGTTTGATGG
TGCTGGAGAAGGTTACCACAGAAAGTGATGACTGTGCTACCTTGAAAGAGAAGCAGGCATTTTCAAGGCC
AGAGGAAGAGCTTCCACCAAGAAGAAGCAATGTGAACAAAGGCTAGGCAGCGGGGAGACCGAGAAAATAT
GGGTTGTTTGAGGCCTCAACATTTTTACCATAAATAAGGCAAATGTAGTCACATTTTACAGAAAGAATGC
ATTTCTAAAGATCTCACATAGTTCAAGGTTACCTTTTCTTTTCTTTTGTTTTTTGGATACAGAGTTTCGC
TCTTGTTGCCCAGGCTGGAGTGCAATGGCACGATCTCGGCTCACTGCAACCTCCACTGCCTGGGTTCAAG
TGATTCTCTGCCTTAGCCTCCTGAGTAGCTGGGATTACAGTCATGCACCACCACGCCCGGCTAATTTTGT
ATTTTTAGTAGAGACGGGTTTCTCCATGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTTCCTGCTTCG
GCCTCCCAAAGTGCTGGGATAACAGGGGTAAGCCACTGTGCCCGGCCTAATTTTGTATTCTTTTAGTAGT
GAGGGGGGCGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCTGCCCGCCT
TGGCCTCCCAAAGGCTGGGACTACAGGCAAGAGCCACTGCGCCCAGCCAAAGTTAACTTTTCTTTGGAAA
AAACGTAAAAGTTTGAGAGGAGATATTCTTGGAGTACATAAACCTACAACAACCAAAGCATATTGTTGCT
TTCTTTCTTTTTTCAACTTTCTCAGCATTATTACTAGTGTTTTGTAGCCTGCTGTCTCCACACAGCCTAT
TATGGTGGTACTTTGGCCTTTTTAATATTGTTTTCTTGCATATAAACTTGGTTTCAACATATTTATTTGG
AGTTTTTTTTTTTTTGCACAGCAGTAACAATACATCCCTTAGCACTTGGATAACATTATCATATATAAAA
TTATTTAAAATTATGTTTAAAAAGCACAATAATAACCTGTATGTCTGAAGAACTTCTGAGTTATTTAAAG
TCTAATTTACATAATAATGACATGGAAGCAGATAATTCTACCAAGTATAAGAGACACTTGCATGTGGCAA
TAGTGTTAACAGTTTATAACTCATTTGACCTGACAGCTTTGAAATTATGTCATTCTAGATAAACTATTTG
GAAGAGTTAACATTATTTCCATTTTGCCCATATAAACTATAATTTTTATACCGTTGCCTAATTCAATTCA
CATAAAATGCAACTTGCAGTATACTTTGATGAAAGCTTGGAAAGAAGAGTCAGACTACAAAGGCCTTGTG
TAAGCAGACTAAAGAGTTTGAACTGTTTTTTCCTGAAAAAAAAAATACTGACTTAAATAGGAGAAAGATA
TGGTCAAATTTGTGTTTTAAAAACTCAACTCACTCTAGAAGCAACATAAACAATGGATCTGGTCCGTGTG
CAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATTGCTTGAGGTCAGGAGTT
TGAGACCAGCCTGACCAACATGGTGAAACCCTGTCTCTACTGAAAACACAAAATTAGCTGGGTGTGGTGG
CACATACCTGTAGTCCCAGCTACTCGGGAGGGTGAACTGCTTAAACCCAGGAGGCTGTGGTTGCAGTGAA
GTGCTCCACTGCACTTCAGCCTGGGCAGCAAAAGCGAAACTCTGTCAACACCACCACCACCACCAAGAAC
AAAAGAATGGACCTGATTGAACAAGATTGGACAGAGGTCAGACAACAACTACTGAAGTAATTTTAACAAT
TAAGAGTTGATGAGGCTATAAATTAAGGTAATGAATTCAAGAGATACTAAACAGCGGGATTTCTCAGCTG
ATCTGTTGTGGGTCAAACAGAAGAAGGAGGAACTGAGGATGACTTCGTAGTTTTTGGCTTGGGCAATTTG
TTGAGTGGTTACCTCATTCATTAAGAAAAAAGAACGAAAATACAGCTCAAGTGTAAAATAATTAGTTCAG
TTTTGTAAATCTGAGATGTGTCACAGAAGTCAAAAGAGAAAGGGTTTCAGGAGGGGCTGCTCGAAATCAA
ACTGTAGAGCTCCTAATTTACATATAAGCTTAAACTTGTTCATTGAATTTGGCAATTAGGAAGTTTTGGG
CAACCGTAGAACAGTTTGGGTAAAGTGGAGGCAGCAGATGGTAGGTGGACAAATATCTAGGACAGAATGG
GAGGGGAAAAGTAAAGACAGTGACTACAAACTATTCTTTTAGGAAGTCTGGCTACAAAGTAGAGAGTTAG
GGAAGTAGTTACTGGTGGTGGGGGGAGAGTTATATACATGTACAAATTTTAATTTGGCTCCACATACATA
GTTCCAATGGTAAGAGATCTAATACATTACTTTTCAAAACATGTCCTAGTTACCTGCCCCAAACTGAAAC
CTGGGAGTCATTCTTAACTCCTTTGTCTAATCTTTCCCTTGTCTGATAAATACTGTAGATTCTAACTCAG
AAATGTCTCCAGAATTTGGTATCTCCTCTCCATCTCCAACAGCACTGTTTTAAATCAAGCCCTCATTACC
CCTGGCATCTTCTATTTTAATACTCTTCTACTTGGTTTTCTTGCTTCCAGACTCTCCTCCATTGTTGCCA
CAGTTATTCTCTCTGCCAGGCCAGAACTTCCCCTTCCCCTGCCTTTTTTTTTTTTTTGCCTGCAAACCCT
GCCTCATCTTTCATCCCGTAACTCCCAGCTTTAATAGTTCCTCTAGGAAAACTTCTCTGCTCTTTCATTC
CTAGCTAATTATTCTCTCCTCAGAGTCCTACCTCCTTCACACCTGTTCATGCTTCTTAAATAGCTCTTAC
TACCCTAAATTGAGATTACTTTGATTAAAAATAGGTCTGTTCAGCTTTCATCTGAGTTTTAAGACAATGA
GTTGTCTTTTTTCCCCTGAATTTTCAACACCTGGAAAGAGCTTACCACACAGTAAGAACTCAATAAATGT
TGTATGAATAAAAGTTTGCTATGATAAACCTTGTTGCCATGACAACAGCGTAGAAAGGGATGTGTAGAAT
ATATATATTTTTTCTATCTTAAACTTTCCCTCCACCTGAAAGCCAATGAGAAGGAGGAAGAACAGGAGGG
AAGCCTGAAAACAGAATTTTAAAAATAGAATAATTTTTCTAATGTCTTCTCCATTTTTCCCTAGTAGTTT
CTTTTTTATTTCATGTGTTGATTTTGAATTCTTCATTCTTATTTTCTTACAATTCTTCTTGTTAGTTCTC
AATACATCTATGACTGATTACAAGTAGTGTGTTCTCATCCCCATTCCTCCTCTCCTCAATTTTCCTCTTC
CTTTCTCATCCGTGTTTCTTTGCTTTAACTCTAATCTATGAAAATTATAGTATCCATTGGATAAAAATGC
TTTGACTATTTCATCTAAAATTCTCAGACTACTGACTTTTTTTTTTTTTAAGAGTTATAAACCACCTCAG
AAAGATCCTCCCAGGAGTAAGCAGTGACAATTTGTTCTTTAAAACAGACATAAAAATTTAGTTATGCAAT
ACTTTGACAACTAGCCAGAGGCTAGTGAATGGTAGAATTTCATGATGGAAATTAGGACACATGAGTTCCA
GTTTTGTCTGGGGCAAGTCACTTAATTTTAAGGGTCTCAGTTCCCTCATTTGGACAAGGAAGTTGGCTAG
TCAGTCTTTAAGGTCTGTTCCAGCTCTACCAACCTGCAATTCTAGACTCTAGTTAAAGCTGTAAGGAGAG
AACCATTGATATGTGGCAAACGGCCTAGTAACCACTTCTTCATAATTCTAAGACAGTAAATATTTATGGC
ATATTTATTATACAACCAGCATTGTTAAGCCACTAAGAGTTTAAAAACATACTATTAGGCTGGGCACGGT
GGCTTATGCCTGTAATACCAGCACTTTGGGAGGCCGAGGCGGCTGGATCACTTGAGGTCAGGAGTTCGAG
ACCAGCCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCAT
GTGCCTTGTAGTCCCAGCTACTTGGGACACTGAGGCAGAATAACTGATTGAACCCATGAGGCAGAGGTTG
CAGTGAGCCGAGTTCGTGCCACTGCACTCCAGCCTGGGTGACACAGCAGGGCTCCATCTCAAACAACAAC
AACAACAACAAACATACTACTAGATTAAAAGTTAAAATGCCTTGAACTTGAAAAGCAACTATGATTATGT
TTATCCTTGCTGTGGAATTCCAATCCTGTTGAATAGGTATGGGATGAAATGAGGGAGCATGCTACATAAT
TAATTACCTGAGATCAGGTAGGTAGTCATCTTGACAGCAACAAGATCAAAACCTAACTTTTCAGTTCTAT
AAATCATTTTATCCTTGAACATTCTGCCATCTTATTATGAATGCGTGTATGTGAGTGTTGAAGAGGTGAG
AGTAGCAGAAAACTTAAAAAATAAGTTTTTAAGTTTTTGTTTTTGAGTCTGTAGACTCAAAGCAAAAAAA
TCAAAATGGAACTGATGTAGTTTAAATGGCCTAGTTTGAAAAGGAGAATTGAGTTGAATCTCAAAGAATG
CTTAAAGATTTGAATAGATAGAGAAGGCAATGGACCAGCATTTATGTGATAATCAAAACAATGTTGTGGT
GGGGGTGAACTGAATAGAGCGATGTTTTTTTCTTTTCTTTTCTTTTTTTTTTTTTTTTTGAGACATGGTC
TTGCTCTATCACCCAGGCTGGAGTGCAGTGACACAGCAAACATGGCTCACTGTAGCCTTGACCTCCTGGG
CTCAAGTGATCCTCTTGCCTTAGCCTTTTGAGTAGTTGGGACTACAGGCACATACTACCACATCTGGCTA
ATTTTTGTATGTTTTGGAGAGACAGGGTTTTTGCCATGTTGCCCAGGCTGGTCTTGAACTCCTGAGCTGA
AGCAATCCACCTGCCTTGGCCTTCCAAAGTGTTGGGATTACAGGAGTGAGCCACTGCACCCAACCTGTGA
TTTTTGGATTGTAGTGGAACAGTCCTGCTATTTTGCAGTGAACACAAGGTAAAGTCGGATTAGATTATGG
AGGGCTTTGGAAATCAGGTAAAAGAGTAAATTTAATCTCACAGGCAATAGGAAAACATTGCAGATAAAAA
GTTATTTTGAAGGAAGTTTGTTTGTTTTTTTGTTTGTTTTTTTGAGAAAGTCTCGCTCTGTTTAGTGGCT
GAACTCACCACAGATTTGGCTATCCTGGGCTCAAGCAGTCCTCAGCATCCTGAGTAGTTCTACAGGCATG
CACCAACACACCCAGGTAATTTTTTATTTTTTTGTAGAGACTGTGTTGCCCTGGCTGGTCTCAAATTCCT
GGGCTCAGGCCTGCCTGAGATTCTAGGCATGAGCTAGTGCACCTGGCCTGAAAGAAGATTTAATAGAACG
TAAAGTAGCTGAATATAGGCAAAAAGACGAATTTCAGGAGTCCTAAAATTTAGGGGGTCCTAATTTTTGT
TATTCAACTTCAAACAGAGATATTTATTCAGCCCTTTCCTTAATTGTGAAAGAAAATTATCTCGGGGAAT
GCTATATTATCCAATTGTAGCCCAGTCCAAAGGTGTGGCAGATTTCACAAGATGACTAACCATGGGCAAA
TTTTTTGTTTGCTTTTAATGTAACTGATTCTGTCTTGAGATTCCGTTTAAAGAGAAGCTTATTTATTTTA
CCACTCTAAAGCAGCAATTCTCAGGGAGTTCCTAAAGTGAAAGCTATTTCTAATAATTCTAAGACGTAAT
TTGTCTTTTTCACTCATTCTCTCATGAGTGTACAACAGAGTTTACCAGAGGCTACATTCTGTGCAATATT
GCAATAGTCTGAATGCAAAGCAGATGAGAATCCAGCAGATCTATATGGCTTCTATTAAACCAGTTAAAAC
ACTTGTAAAAATAAAAAAGTGTCACTCTTTATGCTTTTTTTTTGTTGTTAAAAAAGTACATAGTTATTTT
TAATTAAAAATGTTACTTATGCTAACATGTGATGTGCTTAGTGTAAAGGGAACATGAGAGCAAAAAGTTT
GAGAACCTCTCCTCTAAAGTGATACTCTCCCATATCTGATAAAAGAAAAAAATTCTACTCTGACTTTGCT
TATATTTCTTATGTTGATACTGACTGCTCATCGTAGTGATGCTAGATGGTTTATATTCCTCTCAATTGCT
TTCTAGCTTATTTACCTCTAATTGCCATGGCTGACTTTCCAAATAAAGAGGAATGATATTTCTTACCTGC
GACAAATAGTTTGTTGCGAGAGGAAGCGATCTGGAAGGTCTGAGGTTCCTTTCCTCTTCCCGAAGCTGTG
TAGACTGCAGCAGGTGGCAGCCGCTTTAGCAGCCAGAGTTGGCAGCCAGGAGGGCAAAATGCACTGGGAG
ACAATTCCTTGCTGACTGTCCAGGCAGTCGCCAGGGGAGCAAAGG
|
| Protein Name |
IL18_HUMAN |
| Length |
193 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
15-JUL-1998 |
| Definition |
RecName: Full=Interleukin-18; Short=IL-18; AltName: Full=Iboctadekin; AltName: Full=Interferon gamma-inducing factor; Short=IFN-gamma-inducing factor; AltName: Full=Interleukin-1 gamma; Short=IL-1 gamma; Flags: Precursor |
| Primary Accession |
Q14116 |
| Accession Version |
Q14116.1 |
| Other SeqIDs |
sp|Q14116.1|IL18_HUMAN,gi|3219817 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before Feb 8, 2013 this sequence version replaced gi:74722873, gi:74738962.; [FUNCTION] Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:33883744}.; [SUBUNIT] Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell (PubMed:25261253, PubMed:14528293, PubMed:25500532). Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion (PubMed:32272059). {ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25261253, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:32272059}.; [INTERACTION] Q14116; Q15847: ADIRF; NbExp=3; IntAct=EBI-3910835, EBI-7162516; Q14116; Q13478: IL18R1; NbExp=2; IntAct=EBI-3910835, EBI-9817499; Q14116; Q9IW12; Xeno; NbExp=2; IntAct=EBI-3910835, EBI-15748155.; [SUBCELLULAR LOCATION] Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33883744}. Note=The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33883744}.; [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14116-1; Sequence=Displayed; Name=2; Synonyms=Delta3pro-IL-18; IsoId=Q14116-2; Sequence=VSP_044934.; [INDUCTION] In macrophages, release is increased by endocannabinoid anandamide/AEA. {ECO:0000269|PubMed:23955712}.; [PTM] The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form. {ECO:0000269|PubMed:15326478, ECO:0000269|PubMed:25261253}.; [MISCELLANEOUS] [Isoform 2]: Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4. {ECO:0000305}.; [SIMILARITY] Belongs to the IL-1 family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Interleukin-1 entry; URL='https://en.wikipedia.org/wiki/Interleukin_1'. |
| Source Db |
UniProtKB: locus IL18_HUMAN, accession Q14116;; class: standard.; extra accessions:O75599,Q6FGY3,Q6WWJ7; created: Jul 15, 1998.; sequence updated: Nov 1, 1996.; annotation updated: Oct 12, 2022.; xrefs: D49950.1, BAA08706.1, AY266351.1, AAP92112.1, AF077611.1, AAC27787.1, AY044641.1, AAK95950.1, CR541973.1, CAG46771.1, CR542001.1, CAG46798.1, AP002007.4, AP002884.5, CH471065.1, EAW67184.1, BC007007.1, AAH07007.1, BC007461.1, AAH07461.1, U90434.1, AAB50010.1, NP_001230140.1, NP_001553.1, XP_011541107.1, XP_011541108.1, 1J0S_A, 2VXT_I, 3F62_B, 3WO2_A, 3WO2_B, 3WO2_C, 3WO2_D, 3WO3_A, 3WO3_C, 3WO3_E, 3WO3_G, 3WO3_I, 3WO3_K, 3WO4_A, 4EEE_B, 4EEE_D, 4EKX_B, 4EKX_D, 4HJJ_A, 4R6U_B, 4R6U_D, 4XFS_A, 4XFS_B, 4XFT_A, 4XFT_B, 4XFU_A, 4XFU_B; xrefs (non-sequence databases): CCDS:CCDS44731.1, CCDS:CCDS58180.1, PDBsum:1J0S, PDBsum:2VXT, PDBsum:3F62, PDBsum:3WO2, PDBsum:3WO3, PDBsum:3WO4, PDBsum:4EEE, PDBsum:4EKX, PDBsum:4HJJ, PDBsum:4R6U, PDBsum:4XFS, PDBsum:4XFT, PDBsum:4XFU, AlphaFoldDB:Q14116, SMR:Q14116, BioGRID:109819, DIP:DIP-3785N, IntAct:Q14116, MINT:Q14116, STRING:9606.ENSP00000280357, ChEMBL:CHEMBL1741305, GlyGen:Q14116, iPTMnet:Q14116, PhosphoSitePlus:Q14116, BioMuta:IL18, DMDM:3219817, OGP:Q14116, CPTAC:CPTAC-1249, CPTAC:CPTAC-1250, CPTAC:CPTAC-1431, CPTAC:CPTAC-1432, CPTAC:CPTAC-1433, CPTAC:CPTAC-1434, CPTAC:CPTAC-1435, CPTAC:CPTAC-705, EPD:Q14116, jPOST:Q14116, MassIVE:Q14116, MaxQB:Q14116, PaxDb:Q14116, PeptideAtlas:Q14116, PRIDE:Q14116, ProteomicsDB:59823, ProteomicsDB:67779, ABCD:Q14116, Antibodypedia:1287, CPTC:Q14116, DNASU:3606, Ensembl:ENST00000280357.12, Ensembl:ENSP00000280357.7, Ensembl:ENSG00000150782.12, Ensembl:ENST00000524595.5, Ensembl:ENSP00000434561.1, Ensembl:ENST00000528832.1, Ensembl:ENSP00000434161.1, GeneID:3606, KEGG:hsa:3606, MANE-Select:ENST00000280357.12, UCSC:uc001pnb.2, CTD:3606, DisGeNET:3606, GeneCards:IL18, HGNC:5986, HPA:ENSG00000150782, MIM:600953, neXtProt:NX_Q14116, OpenTargets:ENSG00000150782, PharmGKB:PA29802, VEuPathDB:HostDB:ENSG00000150782, eggNOG:ENOG502SDJZ, GeneTree:ENSGT00390000001053, HOGENOM:CLU_113349_0_0_1, InParanoid:Q14116, OMA:GKNFCLY, OrthoDB:1190337at2759, PhylomeDB:Q14116, TreeFam:TF336297, PathwayCommons:Q14116, Reactome:R-HSA-448706, Reactome:R-HSA-5620971, Reactome:R-HSA-6783783, Reactome:R-HSA-6785807, Reactome:R-HSA-9012546, Reactome:R-HSA-9660826, SignaLink:Q14116, SIGNOR:Q14116, BioGRID-ORCS:3606, EvolutionaryTrace:Q14116, GeneWiki:Interleukin_18, GenomeRNAi:3606, Pharos:Q14116, PRO:PR:Q14116, Proteomes:UP000005640, RNAct:Q14116, Bgee:ENSG00000150782, ExpressionAtlas:Q14116, Genevisible:Q14116, GO:0005829, GO:0005576, GO:0005615, GO:0005125, GO:0045515, GO:0032148, GO:0001525, GO:0008283, GO:0007267, GO:0071407, GO:0042632, GO:0050830, GO:0061436, GO:0006954, GO:0035655, GO:0031663, GO:0000165, GO:0030101, GO:0042267, GO:0045662, GO:0042119, GO:0038061, GO:0042104, GO:0032722, GO:0120162, GO:0032725, GO:0050729, GO:0032729, GO:0032736, GO:0032740, GO:0010744, GO:0032819, GO:0150078, GO:0051092, GO:1901224, GO:0051142, GO:0014068, GO:0051897, GO:0048661, GO:2000556, GO:0045630, GO:0034105, GO:0045944, GO:0042531, GO:0030155, GO:0030431, GO:0042088, GO:0070328, GO:0042092, InterPro:IPR015529, InterPro:IPR000975, InterPro:IPR008996, Pfam:PF00340, PIRSF:PIRSF015162, PRINTS:PR01933, SUPFAM:SSF50353 |
| Sequence |
maaepvedncinfvamkfidntlyfiaeddenlesdyfgklesklsvirnlndqvlfidqgnrplfedmtdsdcrdnaprtifiismykdsqprgmavtisvkcekistlscenkiisfkemnppdnikdtksdiiffqrsvpghdnkmqfesssyegyflacekerdlfklilkkedelgdrsimftvqned |
|
