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Vaegen quary
Vaegen BLAST
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Record Information
Record ID 107
Pubmed ID 33762734
SNP
Gene ID 3417
Protein ID O75874
Vaccine Adverse Events injection site induration, erythema
Vaccine IDH1(R132H)-specific peptide vaccine (IDH1-vac)
Gene Name IDH1
Official Symbol isocitrate dehydrogenase (NADP(+)) 1 [Homo sapiens (human)]
Aliases HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD
Other Designations isocitrate dehydrogenase [NADP] cytoplasmic; NADP(+)-specific ICDH; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrogenase, peroxisomal; epididymis luminal protein 216; epididymis secretory protein Li 26; epididymis secretory sperm binding protein; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase 1 (NADP+), soluble; oxalosuccinate decarboxylase
Chromosome 2
Location 2q34
Annotation Chromosome 2 NC_000002.12 (208236227..208255071, complement)
MIM 147700
DNA Sequence >NC_000002.12:208236227-208255071 Homo sapiens chromosome 2, GRCh38.p14 Primary Assembly AATGGTAATTAGCACTTAATTTTAATTAAAATCAACAGTTCAGGAGAAGATAAGATAGTGTTTAATATCA ATTTCTGAGAAATCACATTTATATAAAAGAAATAAAACAGGCCAGCAGAAGTCCAAAAAAGATTCAGCTT ACATTATTGCACTTGGATGAAATATGCTATTTAGAGTAGTATAATATTCAGGCCAGGCCAGGAGGAGAAA GAGAAAAATGGAGAGGACAAACCTCCAGGTAGTATTTATTCCGGATTCCAAACTCTCCTGCGGCCTAAAC AGTATTTAGTCTATTGGAAACATTCAGCAAGGTCTTTACAAAAATGACTGCAGTATCTTCAACACATTTG AGTTGCACTCCTACTTCGTTCCAGTCATGTGCAAGTTTAATGCACAGCTCTACCTCACAAAACGGGATAT CTATGACACCAGAACTTCCCTGTGCCCAAGGTCATGGACAGGAGGGGAAGGCAGTGAATTTCTACTTTAT GCATATTTTAGGGAGCAATACTGTGGCTATCATTTACCCTTTTGAGCAATCTTGATTTTGGTCATTTATA ATTAGAACATGAGAAAAAGTGACAGTGAATACAAATGAGTACTAACCGAATTCCTAGGCTGGTACTAGAA AATAAAATAAAAATTGTAAAAAAGTCCCTTGCCATGTTCACAAAGGTGGCAATAACTGTATATATAAGAA AAAGGCTGTAAACTTATAGAAAAGATAAACTCTGGCTTCTAAACAAATTACAAAATTGATTTTGCCTTTA TCCTTGAGTGTAACACAGAAAAATGTAAACCTGTAGACCTAGTTACCAAAAGACAATTATCCTTCTTAGC TCAGGTATGAACTTAAAGTTTGGCCTGAGCTAGTTTGATCTTCAAGTTTTCTCCAAGTTTATCCATGAAC TCAAATGTATTCAAGTAGTCAGAACGTTGCACACTAACGGGAAGGAAAAAAAAAAGAAAATTTAGTTGGT CTCTGATATGGTAGCAGGTAGTGGTAAAGTCCTAGAAATGCTACTTAAAATAGTATTCTATTTGTTTCTG GAAGAAAACGCATTCATGTTAGTAAGCTACAAAATCTATAGACAATGACTATGTTCAGGGTTCCTGGGGC TGACCCAGGCTCAGTACTCAGGCTCTCTAGGCAACCGGCAGTAGAGACAGCCATACATACTCAGTTAGGT TTCTTGCTATGTAGCTTTGGGGGTGAAATTATCATTGAGTTTCGGTTCAGACTAATGCTGCTGAGACCAA AATCATCACACTTCTTCCTCATTCTTAAACATAACAAAACTTATTCAGGGCATAGCCAAACCTTTACCCA CCTTCCCACAAACCGTTACATGTCCTTAAAAAAAGTTATAATGTTGTTATTTCTATCAGTGTCTTAAGAA AAACAAAAGACAGGCCGGGCCTGGTGGCTCACGCCTATAATCCCAGCACTTTGGGGGGCCAAGGCGGGTG GATCATGAGGTCAGGAGATGGAGACCATCCTGGCTAACAAAGTGAAACCCCGTCTCTACTAAAAATACAA AAAAAAAAAAAAAAAAATTAGCCGGGTGTTGTGGCACAAGTCCCAGCTACTTGGGAGGCTGAGGCAGAAG AATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCGAAGATCACGCCACTGCACTCCAGCCTGGGCAA AGCGAGACTCTGTCTCAATAAAAAGAAAAAAAAAGAAAAACAAAAGACAGGATAACATAATCCTGCTGAC AGGTGCCTGTTAAATAGGCTACAAAGGTATTCCACTGATAAGACCATTTTGAACACTGCAATCTTTTTTT TTTTTTTGAGATGGAGTCTCGCTCTGTCACGCAGGCTGGAGTGCAGTGGCACCATCTCGGCTCACTGCAA GCTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCGC CACCACGCCTGGTTAATTTTTTGTATTTTTAGTGGAGATGGGGTTTCACTGTGTTAGCCAGGATGGTCTT GATCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACAGC ACCCAGCGAACACTGCAATCTTGTTGGAAATTTAAATTAAGAAACATGCAGTGACCAAGTATATCCCCAT TATGGGGTATACTGACCCTACCTGGGACCTCTGCAGATGCACTGGTTGAGATATGGAGACAATCCCCCCA GGATACTGGCTACTATGTTCTCAGAAAAATTCTCAGTAAACATATGGGCTGTCAAATATTTGCCCAAATA TTGGTTACAGATACTTAAGGGACTGTAATCAATTGCACACCTTAAACTTGTGCTGCTCACTTTTCTCATC AGTAAGTTAAAGAAAATAAAGGAGTAGAATAAAATAGCCTCTGAAGTATCTTTGTTTCTATTTGTCTATA ATCTGCTTCTTAAAATTAAATAGAACCTTTTCGTTCAATGATTATCAACTAGATGGGATGTCAGCAAATT ACAGCCCAGCACATGAACCAAATCGAGGCTGGTTTTGAACATAAAAGTTTGATTGGTACCAGCCACACCA TTTGATTCTGTATTGTCTATGACTGCTTTCCTGCTACAATGGCAGAGGCAAAGTTGAATAGTTGTGTAGT TGCAAAAAGACTATATGTTCCACAAAGCCTAAAATGTTCACTATCTGACAATTTACAGATATCTGCTGAC TCCTGAACTAGATGATGAATAACAATTTATATAATTCCAGAAAGCACCGATGCTCTGAGCCCAGTGAGGA TAAGTGTTAATTTGACCATAGAAACTAGGGCATCTTATACTTACTTGGGTAAACCTTTAATGCAAGCAGC CAAGTCCTTGGTCATGAAGCCAGCCTCAATTGTCTCAATAGAGACTTCTTCCAAAGCATTTGCAAAGAAG GCAAGCTCTTTATTGTTATCAAGCTTTGCTCTGTGGGCTAACCCTCTGGTCCAGGCAAAAATGGAAGCTA AAAGAGGGGAAAAAAAACACAACACTCCAATCATCCTAGTTATAGAGGTTTCCAAATGTCTCATAGTTCC CCAAAACAGAATAGTTTTTTGTTTAGGTGACAGACTTCTTTAGATACTAACCACATGGGCTAGAAGTTTT AGGAGAGTTAGAAATATTTTACCAAACAGAAACTTTAAAAAAACACATTTTCATGGCATGGTACTAGTGT TTGAAACTTAAGGCATTTTCTAATTTGAAAAAGGTCACAATCTCTTCTATCTCTTGTCTATATTGGTCTC CTTTTTCCAGGCTGTAATCTCTTTTTGAAGTGCTATCTTTGAAACTTGTTAAAAGGATCTATCCATGTGA CTTTTAGATTTGTAGCCTTATGTGACATTTCACTGCACCAGAGGTAAAGGAAAATGCTTGTTGATAACAT TCCTCTCTGTAACCTATGTTCTCCCACAAAACAGAAAAGCAAATATTGTATATTTTAAGAAGCATATTCA AATAGATCTTACTAGTAGAACAAATCAGCTACTTGGTGATGACTTTGCACACAAAACACTGAGCAGCCAA GGGAACACATCTGGGCTGCTTTGGAGAGCACTCTCTGGTGAGAAATCAATGTAAACACCATCTTACCAAT GGGATTGGTGGACGTCTCCTGTCCTTTCTGGTACATGCGGTAGTGACGGGTTACAGTCCCGTGGGCAGCC TCTGCTTCTACTGTCTTGCCATCTGGACAAACCAGCACGCTGGTCATCATGCCGAGAGAGCCATACCCTG TAAGTAGTGGAGCATGAAGCGTTGGGTCCAACTGCATGAAGAGCACTGAGTCTCTCAGAGATGAGAGCAT AAATGACTCAATCTTGATAGGTCTTGGTAAGCAAAGTAAACAAGAGCACATGGAATCACCAATAATTCTG CCTTTCAGAAGGCAGGATCCCCGCTCCAGATATCAGAGCCAATGGGTCTGGAAAGGCTGCATTTTCCCCT CACTTATTTCAGGGATACCTACTCCTTGATGGAGGGTTCAGGGTCCAACTGCCTACATTCCACTCTAGTT CTATGACTTCATAGCTACTGCGGCTCAGTTTTCTTATCTGTAAAATGGGAGTAATAACAGCACCTACTTC ACTAGGTTGCTGTGGGATTAGATAAATATACATATATTCATAAATATATATGAATATATATTTATATTCC TTAGAATAGTACTGGACACAGAGCTCAATCTATTATTGTTATTCTTATGTGCAATGCTCTGCTGTTCTGG GGAAATAAAGATGGACGAGAGCTGTCTCTTAAGAACCCTCAAGCTGCTCATACACTTGCTGGGACTGGGA AGAGAAGGCAGGTAAACACAGGATCGGTTGGATCTAAGAACATCCCAGTTGCCCTTCCTCGCTCTCTTTC ATACCCTCAGTACAACAGTTCTCTTCTGTGGTTTCTTATTGAAAGAACCACATTACAACTCTTATATCTA TATAATTGATTTTCTTCTTTTCTCCATTTTTGCTACCTCCCAACATCACCTGTGAAGTTAATAATCAACC ACGGAGTCATCACAAAGCAATAACACTCCTTCCTCTGTTGCATTCAGTACAAATGATTGTGAGGATGTAG AGAAACAGAAGGATGGTAAGGAGAGTTGTGTAACTCATTTATCTGGCAAAAAGTTATCTTTAACCAGGTT GATCTACTGATTTTCAAACTGAGAGGAGATGTTTAACACTGATAAGAGACAGAAAAAGTAGTACTTCTTG GGAAAAACAAACATAATTAAAGTTAACAAACATTCATCTGGGGAGATTCAAGTTCATACAGCTACCAAGG GCAACTGAAACTGAAGGGCAACTTGGTGCTGAGGAAACCAGGCGCTGTGTTTCTGTTGATTTGGCCCTTA CCCCATGCATGAAACTTCTCCTGGAATTTCTGTAAACAGCCCCTAGGGTTCTTTGCTCAATTGATTTGTG TGTAAGCTAAGCAGTAAACAAAAACACTTTTTCTTTGTTGTTGTTGAGACAAGAGTCTTGCTCTGTTGCC CAGGCTGGAGTATAGTGGCGTGATCTCAGCTCACTGCAACCTCCGCTTCCCAGGCTCAAGAAATTCTCAT GCTTTAGCCTCCTGAGTGCCAGGGACTATAGGCATGCGACCACACCTGGCTAATTTTTTTTTTTTTTTTT TTTTGAAGTAGAGATGGGGTTTTGCTATGTTGGCCAGGCTGGTCTTGAACTCCTGGCCTCAAGTGATCCA CTGCCTTGGCCTCTCAAAGTGCTAGGATTACAGGCGTGAGCCACTGTGCCCAGCCAAACACATTTGTTTT ATATTCTACCAGAACAGCAGCTGGCAGAGGGACATGAGTAGGTCCTGCTGCCCAATAAATGAGCTTTGCA GGCACCAAAGCTTGGTTATGACATGATCAAGCTCCTCACTTTATCCCTCCTTGCCTGAGTGCCCTGGTTT TTTACATTTTCACCAAAGGACAAGGAGGGCAGGGAAAGGGAGTGATTTTCAGATCAGGTAGGCTTTAAAA CTTCAAGGAGTGACACTGGAGCCAGGAGTGTCAATCCACTAATTTACTTCCCATGTGGTCTTGAGTAAAT CATTTCTCTAGTCTGAGCTTAATTTCCTTAGCTGTCAGGTAAGACGGTGGACCTGGAGGTTTAACATTCC AAGATTTTACAACAAAGGACTACAAAACTCCCCTTCCCAAATTAGAGAACTACCCTGGAATGACCCTGTT CCTACAGGCCAGGCTCCACCTCTGTACCTTGGGCCACAGAGTCCGACTGCACGTCACCATCATAGTTTTT ACAGGCCCAGATGAAGCCTCCCTCTGATTTCATAGCTTGGGCCACCATGTCGTCGATGAGCCTATGCTCA TACCAGATCTTTTGAGCTTCAAACTGGGACTTGTACTGCCTGGGAAACAAAAGGTAAAAGAGAATAATAA TAAAGAAAATTGATTTTGTTAGGGATATCATCTGCTTGTCCCAAACAGAAGACCGGACACACAAGAAGCA GCATATTTTAGTAGAAGTAGCAGAAACTCAGGAATCTGACAGACATTGGCTCAAATCCTAGCCCAATCAT TTTCTAACTGTAAAACTCAATTTGACTATCTGTAGGAACAATTTTACCCACCTTGCAGGGAAGCCGTGAG AATTAAGTGAGACAGTAGAGTATCCCAATGACTACTTCACTTTTCAGTTTTCATTATACTATAGATCAGA TTCTTGAGATTCAGCTTATTTTTAAAATACATTTTTGAAAAGACTGTTCTACTTCTTGGTGTCATTCAGG AAACTAAAATATATTCCAGACAGTTTCTGGGCTTGGTATAGATGGGCAGCAGGAGGAGGAATCAAAATGC CTCAGGAACATTTTGGCCTGAACACTTGCACCTAAAGGGAGTTATGCCAATCTTAAATATTAACACATGC TCACCTCCTGTGCTGTGGAAGCCAGTGTTGTTATAAACTTAGACTTAAGTTCAAATGACTCCACTAAAAC AGAATTTTAAATTCTTTTTTTTCTTTTCTTTTCTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCC CAGGCTGCAGTGCAGTGGCGTGATTTCGGCTCACTGCAACCTCCGCCTCCCGGGTTCACGCCATTCTCCT GCCTCAGCCTCCCCAGTAACTGGGACTAGAGGCGCCCGCCACCACGCCCGGCTAATTTTTGGTATTTTTA GTAGAGTCAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCG GCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTGCCTGGCCAACAGAATTTTAAATTCTAACAA TGGGCTTCAGAAAGAATGGAAATGGGTCTGACTTAGAAACTCACACATGAAAAATTAGAACTTATCACTA ACAGCGTACGTTTATTTAAACATTAAAGAACCTGGCTCTGAAAACAATTCATGTGGGGACCTTATTTAAG AACATGTTTATCTTATAAAAGCAAGTCAGAGTGGTTTTGTTTCACTCCTGCTAAACCTCAGTTTTGCCCT TATCTTTAAGAGACAGTGATGATTTTCACTCAATTTACCCAGAATCATAGGGATAGGGAGATACATACTC TATATGCAAATGTCAGCTTACTTGAGAATAAAGAAAAAGTTAAAAAAGAACTATAGTTACTTGTCATATA TCTCCTGAAAGATGTCTTTAAAACGCCCATCATATTTCTTCAGAATAGTGTTTTTGGTGCTCAGATACAA AGGCCAACCCTTAGACAGAGCCATTTGGAAGGAACTGTGTGCAAAATCTTCAATTGACTTATCTTGATTA TACATCCCCATGGCAACACCACCACCTTCTGTAGAGGAGAAGCCAGTGAGAGGAAAAAAGGGAGAAGAAT AAATGTAATGTAGTTGTAATAAGGCTAAAATCACCCACCACAACCAAATGACCTACTTCTCAGCTCTCAC ATCTGAGACTAGATTTCAGAAGTCCCAGACAGGTTTCCAACAAATTTCTGAGGCACATAATGAGAGAAAA GCCAGTTCTAGATAAGGACATTCTAACTTGTTTTGGAAGGACAGCAGAAATGAAAAAACATACAGTCTTT AAAATCCTGAAGATGCAGAAATGCCAAAAACTGATATGAACCAGAAATACATTTAAGAAAAGGCAAATAA TTTTGAAACTTCTTTTACATACTGATATGGTTTGGATATTTGTCCCTTCCAAATCTCATGTTGAAATGTG ATTCCCAGTGTTGGAGGTGGGGCCCAGTGGGAGGAGATTGGAACATGGGGTTGGATCCCTTATGAATGGC TTAGGACCATCCCCTTTGGTGATTACGTGAGTTCTCGCTCAGTTAATTCACTTGAAATCTGGTTGTTTAA GAGTCTGGGACCTCCCCCTTCTCTTTCTCTTGTTCCCGCTCTTGCCATGTGATACACCTATTGTCTGTTT GCCTTCTGCCAAGATTGGAAGCTTCCTGAGGCCCTCACCAGGAACAGGTGTTGGAGCCAGGCTTGTACAG CCTGCAGAACCATGAGCCAATTAAACCTCTTTTCTTTATAACTTACGCAGCCTCAGGTATTTCTTTATAG CAACGCAAGAATGGACAAACACCCTACCTTTACAATTCCCAACATCTATTTTAAACTTTAGGGGTGTACT CAATCCTCAGTTATTGAGAAAAACTTAAATTTCAAATACTGAATGAAAATTCTTATAATCTCCTGGAGGA TACTGAGCACTCCTACTGTAGTTGGTAGAAATAAGTAGAAATAATTATGCTACATGTAATCACTGTGTTT TACAACTATTATTGAACTTTGTTATTACTTAAAGATAGAACTTGAATCCATGCCAATGCTCAGGGTTAAC TTGGGTTCAGGGTGAAAGGTGCTGAAGCCTGCAGAACCAGATTCCAACAGATATTATTTGGAAGAGGCAA GAAAAACAAAAGGTAGGTGAGTGTTGGGTATTTTTGTTTGTGTGAGTGCTTTCAACAACTTCAATAGTGA AGGAAAAGGGCCCACTAATTATTTCAACAACTTTTGGGTGGGATTTGCCATCAAAGGTAGCAGGGTAGCT GGGAAAGAAAAGGCAAAAAGCAAATGTTCTACTTTTTCACAGGATAAATACCCAGAAGGGCAAGAAGAAA ACTTCAGCAAATATATAAGGAAACCTCTTCCAGATACAAGAGCCCTACCAGAGCAAAGGGCAGGATTATA TGCTGGGTGATTTGAGAATATTAATATTTAATGTATATAATTCATGCACAGCAGATTTCTGCCAACCTTC TCTCTGTGCTTTAAGATAAATGCATAATCATCTCCTTGTCTTTGCCTAAAGGCATTTCCAATTAAGTGGG TAACCCTTTTGTGCCTTTATTCATGCCACAGGAAGGTATGGAAGCAAATTACTTCTTTATGTCAAGTTTC GGGTTTTGCAAAAACACTGTAGATTCAGATTATATTTTTAGGCAGTCACATAACTAACAAAAAAAGCAAT AAAAATATTATCTAAATCATTTGTTTAAAAAAAAAAGAAGCTTATGCTACAGTCATACATACCTTCAAAG TTATGTACCAGGTATGTCACCTTTTGGGTTCCGTCACTTGGTGTGTAGGTTATCTCTACTTTTCCAGGCC CAGGAACAACAAAATCAGTTGCTCTGTACTGTGTAGAGGGGAAAAAGGTATAAAGAAAAAAAAAATACCC TAGCAGGAATTGTAAGGAGAATATTCATATAATATAGACCTAGAAGACACCTAGACAAATAGGGCAGTAT GTCAAACTTCTTTTTTTTTTTTTTTTTTTAGGAGATGGGGATGAAGAGGTCCAGACATTCCCCTAAATCA GTAAATATTTATTAGGTGCCTATACGAGGTATAGGAAAGTTTTCTGAGCACTGATTTGAAGAGGACAGAG AATAACATAAGCCACTTTCCTTTAGGAAGTTTACAACCCTATAAAGACATATATAAGTGAAAAGCAATAT AAGAGCTTTCAAATGCCAAAAGAGGGTATTAGACCCCCCCCCCAAAAAAAAAAAAACTATAGGATGACAG AGGAAAAGAGGTGACCATGGAAGGAAGTCAGGGAAGTCTCCCTAGAGGGTGATGATAACAATACTAATTG TAGTACTGAGGTAGCTAATGCTTTGTCCTTACTCTATGCCAGATGCTTTAAATGCTTAACTTGCATAATC TCATTTGATTCTTACATCAGTCTTACAAGGAGGGAACTATGATATAGTAGAAATAATGCATCCAGGGTCA AAGGACTTGAGGTCTCGTCCTTACTTAGGCCATCGGGGCTCGGTCTCTCATGGTATCATTGTTACTAGTG TTATAGGACTTGTTCATATGGAGCAATCAAATCATTCTGGGAGCAGCTACAATGGGATGATGATGATTTT TAGGAAAGGGCTGTTCAAGGACAGGCACCTCCCTCATGGGCCTCAGCTACTCAGTGGAATAATATGCCTG GCATATACTAGACATCCATAAGTCTTTGCTGCATTGTATCTTCTTCAATGAATTGAATCAGATACTTGCA GAGTTAGGTACCAGCAGGTGCCGGCCACATCTATAAGTGTAGAGAAATACTAATAACAACTGGTAAAAGA GCAGTAAGTAACAATAAAGATTAAACACCTACTTTACACAGAACATTTTTGACATATAAAATCCATAAAG TAAATATGGGTGGTAATTTATTACTATTTCTGAAAAGGGAGAAACTGAGGTACCAAAGCACCATAAATGC TTTGTATAGGTTTATGTATATTTAAACAGTCCATGAATCAACCTGAGGTTTGAAATTCTCTTTCTGGACT TTAATAAATAGAATGGCCATTTTTACAAATGACTGATGCCAAAATAATTAAAAAAAAAAAAAAAAAGAGG AAGGCCGGGCATGGTGGCATGCCTGTAATCCCAGCACTTTGGGAGGCGGAGGCGGAGGCGGGCGGATCAC AAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAACACAAAAATTA GCCGGGCATGGTAGCATGTGCCTGTAATCCCAGCTACTCAAGAGGCTGAGGCAGGAGAATTGCTTGAACC CGGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTC TGTCTCAAAAACAAAAAACAAAAAGGATATACGCAGAAAAAAGGCACGACTGAACTGGAAAGAATCTAGG GTGATTTTTACAAGATTAGCGAGTTTGCACCACTGCCATCTACCTTCCCTTGCTTGGGCCCCTGGGAGCT ATTTCTGAAGGCTTTGGCCAGGATGAAAGGATAGTTTTAGCCACAGAGTGGAACAAAGTTAACTGACCCC TCAAGGACTAAACTGTTTACCCTCAACACACTGTTTTCAATGATGGCTACATTAAAACCTCTGGATTTCA GCATGAGAGATTCCTGTTTTTAAGGTCCTTTTAAGACATAAACTACTTTCTGTGAAAGTCTGAAACCTCA GTTTCAACACTGAACTTTGATTTTGTTTACTTGGCAGTTTTTTTGCTTAATTTGGCAACAAGTGTACTGG TACAGAAGTAAAGAAGCAATACTTTTTTTCCAGGCAGGAAGGAATGCTTTAGTAAGGCTGCTTTCAACTA CCGAGTCAGTTTTTTTTTTCTTTTTCTTTTTCGAGACAGGGTCTTGCTCTGTTGCGTAGGCAGTGGTGTG ATCATAGCTCATAGCTGTAACCTTGAACTCCTAGGCTTAAGGGATCCTCAGGCCTCAGCCTTCCAAGTAG CTGGGACTATAGGCACATGCCACCCCACTCAGCTTCGCCTACTCACTTTGTATATGAATAAACAAAACTG GCTCTTCCATGAACAATTGACATAATTATTGAAATACTTTTCATTTTTGTAGAGACAGGGTTCTGCTATG TTGTCCAGGCTAGTCTCAAACTCCTGGCCTCAAGCAGTGCTTCCAAATTGGCCTCCAAAGTGCTAGGATT ACAGGTGTGAACCATAGTACCCAGCCAGTTTTTTCTTTTATGCATGATGGGATCATGTTTAATACAATCT TTGGTGGTTCTCAAGTTTGCACATTAGATTCACCTGGGGAGCTTTAAAATGCCTGAACCCCATGGAATTC AGATTTTAATTTGTGTAGGGTGGTACTCAAGCATTGAAACTAAAACAAAGAAACAAATCAAGCAAAGCAA AACAAAACCACCAAAAAAACTTGTAAGGGGATCCTATTGTGCAGCCAGTGTTGAAAACCACAGATCTGGT TGAACCATATGAAATTACCAACATAAAAATGGCAATATCATATGGTATAACTGAATAAAAGGATAAAGGA AAAAAAACAGCATGTTTGAAAAAAAATGTGTTGAGATGGACGCCTATTTGTAAGTTTATTTGTATTTGCC TTTAGCTAAATGTGTGTAAATATACAGTTATACATATATGCATTTCTCAATTTCATACCTTGCTTAATGG GTGTAGATACCAAAAGATAAGAATAAAACACATACAAGTTGGAAATTTCTGGGCCATGAAAAAAAAAACA TGCAAAATCACATTATTGCCAACATGACTTACTTGATCCCCATAAGCATGACGACCTATGATGATAGGTT TTACCCATCCACTCACAAGCCGGGGGATATTTTTGCAGATAATGGCTTCTCTGAAGACCGTGCCACCCAG AATATTTCGTATGGTGCCATTTGGTGATTTCCACATTTGTTTCAACTTGAACTCCTCAACCCTCTTCTCA TCAGGAGTGATAGTGGCACATTTGACGCCAACATTATGCTTCTTTATAGCTTCTGCAGCATCCTTGGTGA CTTGGTCGTTGGTGGCATCACGATTCTCTATGCCTAAATCATAGCTTGAAAGAGAAAAATTAGAAGCAAA GTTTTTCAGACAAATGGATAGTTATAACCTACAACTGCAGTGATGGCATATAGAGCTCATTATGCAGAAA GCGAAGGCTCTGAGTACACCAAAATCTGCCAAGTTTTAGCACTGGCACACCCTAAACACAGAAGATGGGT GCCAACTACAAAGAGAACTAAGAGAGGCTAGACTGCTGGGCTGCCCCTCCTCTTGTAATGGGAAGCTGTC TATCAGGAAAATGAATGGAAACCATCAAACTCTGCCCTTTGCCTCCTGTTTTTCACCAGATAGAGGCAAT AATGGCCTGGTTTCTCTCCATATAATTAGTATAATAAGTGTAAGTCTAAGGACCACCTTTTTCCCTTAGT AAATATTGCTCTTTAAAAATAAAAGGGGGTGGGAGGGGTTAAAGGATTTTTTGTATTTTGACGTTGAAGT GGTGGGAGGTAAAGATGTGACAGTTGATGCCAAAAATGCGAATGACTACTTCATTAATGCCAGTTAGTCA TAAAATGAGCCTTTCCCTTTTTTTTTTTTTTTTAGATGAGTCTCGTTTTGTTGCCCAGGCTGGAGTGCAG TGGCACGATCTTGGCTCACTCAACCTCTGCCTTCCTGGGTTCAAGTGATTCCCCCGCCTCAGCCTCCCCA GTAGCGGGGACTACAGGCATGCACCACCATGCCCAGCTAATTCCTTCTGTAATTCTTGAGCAAGTGTTTG CTCTGGAAACAAGCCTACAATTTATTGGGTAAGTAAAGGAATCCATCAATGGTTTTCTACATACCAGAGA GTAATAGCTTAATATACACCAACACAAAGATTGCAGGTCATTCAGAGCTGAAAGAATGTTAGTTGTCCAG GGAGCATAGAAAATGACTGCAAAGCTTTATTTGAAGCATGCAATAGTTTGTTAAAAAGCAAGAAAACAAA ATAATGTTTTGTTTATTCTGTTCTCCAAGGATTTAAAAGGTTTTTCAGCTCTTAAAACCTGCCTCTAGAT TTCTTTTTGGTTCCCTTATCTTCCTTTCTTAGATCTCCTACCCAACTCATGATGCAAACAAAGAGATAGT AATCTTGACATATTTCCAAATAAAAATAACTTCCAACTGCTTCGACTTTAGATAATTCATATAAATCTAA CAAAGTCATGTCCTTTGTTATCTTCTTGCATAGGAAATGTTGATCCAATCCCAACTCCAACAGGAAGTAT GATCAGTAGTTTTCAAGTTCCTAGGAACCATTTCTCATAAGGAGAATCTATCAGCAAATTATTAGATTTT TTGCTTGTCTTCTTAACATTTCTAAGAAGATAAGAAAGGAAGGAACAAATTGCCCAGACCACTGTCCAGC CTACATAAAACAAACTACCTGCTCCATTCTCCTGAAAAAGAACCAGTCAGTGATAATAATAGGAATTTTG GAAAAATTTAAAACTTGTTTGAGCCTCCAAAAATTATCTAGTCTGCAGCCACCAAATTTTTTCCTCCTAG TCATAGTGACTCCCCTTTAAAACTCCTCATGATTCCACACTAAAGAGGCTCAAAGCATCTTTAGTTGCAG CCATTATAAGGAAAAGAACCCTGCCAGTTCACCTACTGTCATGTAAAGTCCTGAAACAGGAGTTCCTAAG ATGCTTTTTTTTTTTAACCTAGTTGGAAGATGTTTTTATGCCTAATTTCTTATGTTTGGTTGACTTCTGC AAGTATTTATATCTTATCATGATTTCAATATAGACATCAGCAGCTTAGGTTTAGAACAATTAAAAAGTAT GTTTAATGACATTATGTGAATTAAATGTCTCCACTCAAACAGGTCCTTAGGACAAATTTTGATGACTAAT TCTGGGCTGAGGCAAACACACTTAGAGTTGCCAATAGTTTGGCTGAAACGTGTTGCTCAATATTTTTCTA TGCCAGTCTTCAGCCACTTTACCCTTTTAAAAATTCTATCTCTACCTAAAGGTACAAAGAACAGAAGCAA GTTTATGAAAAACACAGCGAAAAAAATGAGAGAATTACATAGACTTTTGCATCTGTCCCCAGGCACTTTA CACACAGGGCAAAGGGACACAGGATTTAAGGGAATTTTGCTGGAAAGGAGGGGTTCAACTAAGAAACATC ATGAATTCTTTCTGCACTACAATTGTATGAAAAGGGCAAAAGGTGAGGCATGAAAAGGAAACAGGTCCAT TGACTAAGTAAAGTGATAGAAAATTGAGTTTGAAATGACAAAATTGTGTTAACTGCATTTAGTTTACTGT TTCTTACATCCTCTCTTATTTCCCTTTTCTCAATACATTGTACTATTCTTAGCCACTGTTTTATTACAAA TAAAACCTTCACAGGAAACAGAAGGTTAGAAGAATCTGAAAATCATTCTTTCCCTTATAATTCTTGACTT TTAGATGATAAATCCAGTTTTTCTAGCAGTATGTTAAAATTAGAAGATTCATCTGAATATATTTAGGCTT AAAACAAACTTTATTCACAAAACACAGCTATATCTATATAAAAAAAGCTAACTTCACCTCAAAATAATTC AGATTATATTCTTTTTTTTTTTCCTGTTTCTCCTTCCCTTTTTTTTCCTTTTTTTTTTAAAGTGATGGGG TCTCACTCTGTTGCCCAGGCTGGACTTGAATTCCTGGTCTTGAGGGATCCTCCTGCCTCTGCCTCCTAAG TAGCTGGGACTTCACGTGTGCACCACCATGCCCAGCCAGATTATCCTTTCTGAGTTTGCTACACGGAGGG GTAACTCATTTACCTATGTAGATCCAATTCCACGTAGGGAAAAATGAGTTTCTCTTTAATCAATTCCCAA ATGATTCGTGTCATTTCATCTCCTTGCATCTCTACCACAGAACCGCCACTGATTTTTTTGGACATTTTGA CTTCAATAAACCTAAAAAGAAAAAAAAAATACATGCCTTGTCATTTATTTCATTATAAAGTGAAATATAT AAACAACGTAGTGTTTATATAAACAACGTAGTGACTACTAAAAGAACAATTCATGCAATTCAATTTATGT GTAGTTGAATAAAAAGCTAGTAACAGCAATTCTATTTACCATTAGAATTGAGTATCTTCTCTGAACAAAG TATTGTGTTATGTTTCACACGCGGTTTCTGAGCTAGCCCTCATAACAATCCAAAAAAATGGCCATCATTT CCCCATTTTACTTTGTTAAAAAAAAAAGAGCTTTCCCAAGGCCACCTAGCTAGAGCGTGGCAGAGCCTGA CCCTATAACGTGCCCTTCATAATGCAATCATTATTCTCAACTACTGGTTTGTCTTAAGAAATGAGATTAT TTCCACAATCTCATGTTTATTGAACACTTCAGTCCAACTCATCATTTTACTGGGCTCTCAAGATGTCCAG AATGGTGAGTGCTAGCATTTCTCCTCCTTTAAGAGGCTGTTTTTGTTATTTAATAAAAATAACTAGCCAT GAGGAGATTCAGCTGGTTCCTGTGACCCATATTCAGGGAAACTTTAAGTCTAAAAGCGAGACGAAGAATT CCTGGTGGAACTGTTTTCCTAGAGATAACACAGACATTGGAGATGTGGGGCTAAATACAACAAAGTGATT TCTCAATTAGAAGAATCTCTATACAGTAGGGCCACTGCCCAGGACCCAAGCATGTCCCTGTCATCTTCTT CTGGCTGTTCACAGGCAAGGGTAAGCTGCTAGTGAGTGGGATAGGACAAACTGTGCATTGTCCTAGGAAG ACAGCACTTTAAGGATAGGGTGTGGGGGTAGCATATACAAATCAATCTGATTCTCAGAAAGTGCAAGGTT GGACGCTTTGGAAGAAATGAAACTGTCCCAGCTTGTCCCTAGAGGCAGAAGAAGCTCTGAGCCTGCTAAA AGTTATCTATTCCTTCTAATGATGCTCTAATCGAAACTCTTTTTTAATCCAACAACACAGCTGCAAATTG CTTTTATTCTCTTAAGGACTAAAAAAGTCAAGAGAATTGACTTTAAAGAATTATTAGATAAGAAGCCTAA AATAGTCTTTCTTGAAAAATTGAGCTAAAGTAATTTGGTCTTTAAATAAAAATGTAATGATTAGTAGACA GTAAGCGTCTGTTTCTTGACAAGCCTGGATGTATTTCCAATCCCCAGGCCCATTTTCACTTCCCAAATTC GCAATTCTAGAATTCTTCTTACTAGTGTTTAGGAGATTCCTTTGGGGGAACCTTCTGGAACTGAACTAGA CTAAAAGAAATGAACAGAATGGTGTGGATGAGTCAATTACTTCCCATTTGTAATGTCAAGTATAATTTGT AGTACAGCTGAAAGCATATGATTCAGTTCATGTTTGATTCCACTGTCACACCTATCCTTGTTTTAAAACA AAGCAAAAAAGGAGGCAGTGAACTTATCTGGTTCCTGATAATACACTTCCATGGCCATGTCCCTATATAG TATGATGCAACAGTCATGACATGGCAATTTATTCTTGATGGCAAATACAGTTAATAGAGGTCAAATATTG TACCTAAAATGTGAAGACTGATATCTTTTTAGTTCACTATTTCCTTCTCAGTTAAAGCAACTGTACTCTC TGCAGTAATCTTTCTTTATCTCATAATGCATACTTCAGACGCTTCAGGTTTTCCTCACATTACTTAGCCA TGAAATTTTTACCATCTTTTAACTAAAACAGTGAAGCTTTATTGTTACTACCATGTGGAACATAATTGTA TTTCTTCTGGATCTGATTTCCATGGGATGGGCTTGAGGCCCCACTGGACTGACTTCTCCACCTTTGTTGC CCCTCAGATTTTGTCTCCAACCCAATCCCAACTTCAGAAGGAAGGGCTGTTCCAAGACCAGCAGGCACCA GCTCATATGAAGTAGCTGAATCCTATCTCCTAACATAATTGTGCAATTCCAGAAAATAAACCTGGAATAA CAATACAGAGTAGTTTAATGAAAAAAAAGAGCCATTTAATATTATTTTCATCAACCTCAAGTTTTTGGCC AGATTGTTTTTTGCCGAGTTCATGAACTACAATAATTTCTGGGCAAAAAGGATCTCTTGCAGATAAGACA CTGTATTAAAAGAAACAAGGAAGCTGTTGGAATTCGTTGTTGGAAATATTCCTCACTCATTCCCTTGCAG TGCCTCGGCCTGCCCCCAAGACCAGTTAAACACTGTACTGCCACATCAAAGAAAGTACAGAAGAAGGGGG AAAATTTGCTAATTCTCACCTTGACAGTGAATAGATTTCTTATCACCCCAGTTCCTCCCAGTCTTGCAGA CTCAACTGAATGTAGTTTATCGCCTAAAACAAAACAAGGAATAAAAGTGTTAACATACAGAACACTCACA GGAGAATTTAGCTGTTTTTAGTACCTGCCAGACAGCCCAGTTTATCCGGTTTAAAGTACAGTGCTGAGTG TACTCGGTGGGACAAAGGCCAATTTTAGGCCCGCAGGCACTTTCCAAATAAAGGTCATGGGAGCACAATT TATCTCTGCGTGTGCGAGGGCGTGCCCCCGCTTCGCCGCCCGTTAGCAGGTCTTGGGGTTTGCATGTCCT TGCTCTTGGCCTGCACCCGTCCTTATGGCCGTTGTGCAAGAGGGCTGCAATCAAGGCTGGATCGGTACCT CCTTCCAGGTCTCCACGCCCGCCCCTCCCCTCCCCTCCCCTCGCTGGTGCTGGGACCTTTTAAACTCCAG GCACCCGGAACTGGCGGGGGTGTTTCCCCCAGCCCCCTCTCGCCCCGTGTGGCCTAGCGACCCCTCTGAA GGCCGCTGGAGCTCCGCCCCTCCACGCCCCCTGGCGGACGCGAGGGATCGGCTTCAAGGCTATTCCTCGC CGCCTGAGTTGCCTGCAGACGCCCGTCTGCGGCTTACAGCCTTCTTTGCATCCAGCCCCCAGCTGCTGCA CGTTTTCTTCCTCCTACACTCCAGGCTTAGTCTTCTACATGCATTCTTGCAACTTCCACCCCTCGATTTT CCAACCCAAGTGCAGACCTGATTTTCCCCTTGTCGTTGCATCCAACTTCCTCACCGCCCAGTTTCTCCCT CCCAGGCCCAAAAGCAGACCTTCTGCATATCCAAGCATCCAGCATCCCCTCCTTCCCTTTTCTTTTCCCA TTCTCAATACCTGGATTTGTTCCCTTCTTTGCACGCAGGCCTTGACTCCCTCCACACCCAAGATCTGCGC TTTTTTCCTTTACCCCATTCCTGCCTTCTGCGGAATTAGAGCCACCCCTCCACAGCCAGGGACCGGGGCC GCCCCTTGGAGCCTGAGGTTACCTGCCGGGATGATATGCTGGCGAAGAGTTGGGGCGCCACAGCCGCTCA CAAGCTCAGACTCACAACCACAGCCTGGCAATCCCAAACCGGACTCCCAGTGCCTCCGCTTCTGAAGTAG ACTCTGCAGAAACCC
Protein Name IDHC_HUMAN
Length 414
Moltype AA
Topology linear
Division PRI
Update Date 12-OCT-2022
Create Date 30-MAY-2000
Definition RecName: Full=Isocitrate dehydrogenase [NADP] cytoplasmic; Short=IDH; Short=IDH1; AltName: Full=Cytosolic NADP-isocitrate dehydrogenase; AltName: Full=IDPc; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase
Primary Accession O75874
Accession Version O75874.2
Other SeqIDs sp|O75874.2|IDHC_HUMAN,gi|21903432
Organism Homo sapiens
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Comment On or before Jan 24, 2014 this sequence version replaced gi:74735945, gi:74738987, gi:74723305, gi:11374664, gi:6647551.; [FUNCTION] Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity). {ECO:0000250|UniProtKB:Q9XSG3, ECO:0000269|PubMed:10521434, ECO:0000269|PubMed:19935646, ECO:0000303|PubMed:10521434}.; [CATALYTIC ACTIVITY] Reaction=D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH; Xref=Rhea:RHEA:19629, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.42; Evidence={ECO:0000269|PubMed:10521434, ECO:0000269|PubMed:19935646}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19630; Evidence={ECO:0000269|PubMed:19935646}.; [COFACTOR] Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:19935646}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:19935646}; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit. {ECO:0000269|PubMed:19935646}.; [BIOPHYSICOCHEMICAL PROPERTIES] Kinetic parameters: KM=112 uM for NADP(+) {ECO:0000269|PubMed:10521434}; KM=49 uM for NADP(+) {ECO:0000269|PubMed:19935646}; KM=29 uM for magnesium chloride {ECO:0000269|PubMed:19935646}; KM=76 uM for isocitrate {ECO:0000269|PubMed:10521434}; KM=65 uM for isocitrate {ECO:0000269|PubMed:19935646}.; [SUBUNIT] Homodimer. {ECO:0000269|PubMed:15173171, ECO:0000269|PubMed:19935646}.; [INTERACTION] O75874; P0DP23: CALM1; NbExp=7; IntAct=EBI-715695, EBI-25817233; O75874; P27797: CALR; NbExp=3; IntAct=EBI-715695, EBI-1049597; O75874; P36957: DLST; NbExp=3; IntAct=EBI-715695, EBI-351007; O75874; O75874: IDH1; NbExp=4; IntAct=EBI-715695, EBI-715695; O75874; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-715695, EBI-1055945; O75874; P16284: PECAM1; NbExp=3; IntAct=EBI-715695, EBI-716404; O75874; P17612: PRKACA; NbExp=3; IntAct=EBI-715695, EBI-476586; O75874; P50454: SERPINH1; NbExp=3; IntAct=EBI-715695, EBI-350723; O75874; P37173: TGFBR2; NbExp=3; IntAct=EBI-715695, EBI-296151; O75874; Q05086-3: UBE3A; NbExp=3; IntAct=EBI-715695, EBI-11026619.; [SUBCELLULAR LOCATION] Cytoplasm, cytosol {ECO:0000269|PubMed:10521434}. Peroxisome {ECO:0000269|PubMed:10521434}.; [PTM] Acetylation at Lys-374 dramatically reduces catalytic activity. {ECO:0000250}.; [DISEASE] Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. {ECO:0000269|PubMed:19117336, ECO:0000269|PubMed:19935646}. Note=The gene represented in this entry is involved in disease pathogenesis. Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors. {ECO:0000269|PubMed:19935646}.; [DISEASE] Note=Genetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Mutations of Arg-132 to Cys, Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. {ECO:0000269|PubMed:26161668}.; [SIMILARITY] Belongs to the isocitrate and isopropylmalate dehydrogenases family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Isocitrate dehydrogenase entry; URL='https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase'.
Source Db UniProtKB: locus IDHC_HUMAN, accession O75874;; class: standard.; extra accessions:Q567U4,Q6FHQ6,Q7Z3V0,Q93090,Q9NTJ9,Q9UKW8; created: May 30, 2000.; sequence updated: Jul 11, 2002.; annotation updated: Oct 12, 2022.; xrefs: AF020038.1, AAD02918.1, AF113917.1, AAD29284.1, AL136702.1, CAB66637.1, CR541695.1, CAG46496.1, BX537411.1, CAD97653.1, AC016697.8, AAX93221.1, CH471063.1, EAW70439.1, BC012846.1, AAH12846.1, BC093020.1, AAH93020.1, U62389.1, AAB17375.1, T46280, NP_001269315.1, NP_001269316.1, NP_005887.2, 1T09_A, 1T09_B, 1T0L_A, 1T0L_B, 1T0L_C, 1T0L_D, 3INM_A, 3INM_B, 3INM_C, 3MAP_A, 3MAP_B, 3MAR_A, 3MAR_B, 3MAS_A, 3MAS_B, 4I3K_A, 4I3K_B, 4I3L_A, 4I3L_B, 4KZO_A, 4KZO_B, 4KZO_C, 4L03_A, 4L03_B, 4L03_C, 4L04_A, 4L04_B, 4L04_C, 4L04_D, 4L04_E, 4L04_F, 4L06_A, 4L06_B, 4L06_C, 4L06_D, 4L06_E, 4L06_F, 4UMX_A, 4UMX_B, 4UMY_A, 4UMY_B, 4XRX_A, 4XRX_B, 4XS3_A, 4XS3_B, 5DE1_A, 5DE1_B, 5GIR_C, 5GIR_D, 5K10_A, 5K10_B, 5K11_A, 5K11_B, 5L57_A, 5L58_A, 5LGE_A, 5LGE_B, 5LGE_C, 5LGE_D, 5SUN_A, 5SUN_B, 5SVF_A, 5SVF_B, 5SVF_C, 5SVF_D, 5TQH_A, 5TQH_B, 5TQH_C, 5TQH_D, 5YFM_A, 5YFM_B, 5YFM_C, 5YFN_A, 5YFN_B, 6ADG_A, 6ADG_B, 6ADG_C, 6B0Z_A, 6B0Z_B, 6B0Z_C, 6B0Z_D, 6BKX_A, 6BKX_B, 6BKX_C, 6BKY_A, 6BKY_B, 6BKY_C, 6BKY_D, 6BKY_E, 6BKY_F, 6BKZ_A, 6BKZ_B, 6BL0_A, 6BL0_B, 6BL0_C, 6BL1_A, 6BL1_B, 6BL1_C, 6BL2_A, 6BL2_B, 6BL2_C, 6IO0_A, 6IO0_B, 6O2Y_A, 6O2Y_B, 6O2Y_C, 6O2Z_A, 6O2Z_B, 6PAY_A, 6PAY_B, 6PAY_C, 6PAY_D, 6Q6F_A, 6Q6F_B, 6U4J_A, 6U4J_B, 6VEI_A, 6VEI_B, 6VG0_A, 6VG0_B, 6VG0_C; xrefs (non-sequence databases): CCDS:CCDS2381.1, PDBsum:1T09, PDBsum:1T0L, PDBsum:3INM, PDBsum:3MAP, PDBsum:3MAR, PDBsum:3MAS, PDBsum:4I3K, PDBsum:4I3L, PDBsum:4KZO, PDBsum:4L03, PDBsum:4L04, PDBsum:4L06, PDBsum:4UMX, PDBsum:4UMY, PDBsum:4XRX, PDBsum:4XS3, PDBsum:5DE1, PDBsum:5GIR, PDBsum:5K10, PDBsum:5K11, PDBsum:5L57, PDBsum:5L58, PDBsum:5LGE, PDBsum:5SUN, PDBsum:5SVF, PDBsum:5TQH, PDBsum:5YFM, PDBsum:5YFN, PDBsum:6ADG, PDBsum:6B0Z, PDBsum:6BKX, PDBsum:6BKY, PDBsum:6BKZ, PDBsum:6BL0, PDBsum:6BL1, PDBsum:6BL2, PDBsum:6IO0, PDBsum:6O2Y, PDBsum:6O2Z, PDBsum:6PAY, PDBsum:6Q6F, PDBsum:6U4J, PDBsum:6VEI, PDBsum:6VG0, AlphaFoldDB:O75874, SMR:O75874, BioGRID:109643, CORUM:O75874, DIP:DIP-59311N, IntAct:O75874, MINT:O75874, STRING:9606.ENSP00000390265, BindingDB:O75874, ChEMBL:CHEMBL2007625, DrugBank:DB09374, DrugBank:DB01727, DrugBank:DB14568, DrugBank:DB03461, DrugCentral:O75874, GuidetoPHARMACOLOGY:2884, GlyGen:O75874, iPTMnet:O75874, MetOSite:O75874, PhosphoSitePlus:O75874, SwissPalm:O75874, BioMuta:IDH1, OGP:O75874, REPRODUCTION-2DPAGE:IPI00027223, UCD-2DPAGE:O75874, EPD:O75874, jPOST:O75874, MassIVE:O75874, PaxDb:O75874, PeptideAtlas:O75874, PRIDE:O75874, ProteomicsDB:50234, ABCD:O75874, Antibodypedia:34198, DNASU:3417, Ensembl:ENST00000345146.7, Ensembl:ENSP00000260985.2, Ensembl:ENSG00000138413.14, Ensembl:ENST00000415913.5, Ensembl:ENSP00000390265.1, Ensembl:ENST00000446179.5, Ensembl:ENSP00000410513.1, GeneID:3417, KEGG:hsa:3417, MANE-Select:ENST00000345146.7, CTD:3417, DisGeNET:3417, GeneCards:IDH1, HGNC:5382, HPA:ENSG00000138413, MalaCards:IDH1, MIM:137800, MIM:147700, neXtProt:NX_O75874, OpenTargets:ENSG00000138413, Orphanet:251579, Orphanet:251576, Orphanet:163634, Orphanet:99646, Orphanet:296, PharmGKB:PA29630, VEuPathDB:HostDB:ENSG00000138413, eggNOG:KOG1526, GeneTree:ENSGT00390000012547, HOGENOM:CLU_023296_1_1_1, InParanoid:O75874, OMA:HGTVQRH, OrthoDB:511880at2759, PhylomeDB:O75874, TreeFam:TF300428, BioCyc:MetaCyc:HS06502-MON, BRENDA:1.1.1.42, PathwayCommons:O75874, Reactome:R-HSA-2978092, Reactome:R-HSA-389542, Reactome:R-HSA-6798695, Reactome:R-HSA-9033241, Reactome:R-HSA-9759194, SABIO-RK:O75874, SignaLink:O75874, SIGNOR:O75874, BioGRID-ORCS:3417, ChiTaRS:IDH1, EvolutionaryTrace:O75874, GeneWiki:IDH1, GenomeRNAi:3417, Pharos:O75874, PRO:PR:O75874, Proteomes:UP000005640, RNAct:O75874, Bgee:ENSG00000138413, ExpressionAtlas:O75874, Genevisible:O75874, GO:0005737, GO:0005829, GO:0070062, GO:0005576, GO:1904813, GO:0005739, GO:0005782, GO:0005777, GO:0034774, GO:1904724, GO:0045296, GO:0042802, GO:0004450, GO:0000287, GO:0051287, GO:0050661, GO:0042803, GO:0006103, GO:0008585, GO:0006749, GO:0006097, GO:0006102, GO:0006739, GO:0071071, GO:0060696, GO:0006979, GO:0048545, GO:0006099, InterPro:IPR019818, InterPro:IPR004790, InterPro:IPR024084, PANTHER:PTHR11822, Pfam:PF00180, PIRSF:PIRSF000108, SMART:SM01329, TIGRFAMs:TIGR00127, PROSITE:PS00470
Sequence mskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvsgwvkpiiigrhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl