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| Record Information |
| Record ID |
105 |
| Pubmed ID |
28991404 |
| SNP |
|
| Gene ID |
3576 |
| Protein ID |
P10145 |
| Vaccine Adverse Events |
moderate injection site pain |
| Vaccine |
inactivated trivalent influenza vaccine (TIV) |
| Gene Name |
CXCL8 |
| Official Symbol |
C-X-C motif chemokine ligand 8 [Homo sapiens (human)] |
| Aliases |
GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8 |
| Other Designations |
interleukin-8; T-cell chemotactic factor; alveolar macrophage chemotactic factor I; beta endothelial cell-derived neutrophil activating peptide; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; emoctakin; granulocyte chemotactic protein 1; interleukin 8; lung giant cell carcinoma-derived chemotactic protein; lymphocyte derived neutrophil activating peptide; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; tumor necrosis factor-induced gene 1 |
| Chromosome |
4 |
| Location |
4q13.3 |
| Annotation |
Chromosome 4 NC_000004.12 (73740569..73743716) |
| MIM |
146930 |
| DNA Sequence |
>NC_000004.12:73740569-73743716 Homo sapiens chromosome 4, GRCh38.p14 Primary Assembly
ACAAACTTTCAGAGACAGCAGAGCACACAAGCTTCTAGGACAAGAGCCAGGAAGAAACCACCGGAAGGAA
CCATCTCACTGTGTGTAAACATGACTTCCAAGCTGGCCGTGGCTCTCTTGGCAGCCTTCCTGATTTCTGC
AGCTCTGTGTGAAGGTAAGCACATCTTTCTGACCTACAGCGTTTTCCTATGTCTAAATGTGATCCTTAGA
TAGCAAAGCTATTCTTGATGCTTTGGTAACAAACATCCTTTTTATTCAGAAACAGAATATAATCTTAGCA
GTCAATTAATGTTAAATTGAAGATTTAGAAAAAACTATATATAACACTTAGGAAAGTATAAAGTTTGATC
AATATAGATATTCTGCTTTTATAATTTATACCATGTAGCATGCATATATTTAACGTAAATAAGTAATTTA
TAGTATGTCCTATTGAGAACCACGGTTACCTATATTATGTATTAATATTGAGTTGAGCAAGGTAACTCAG
ACAATTCCACTCCTTGTAGTATTTCATTGACAAGCCTCAGATTTGTCATTAATTCCTGTCTGGTTTAAAG
ATACCCTGATTATAGACCAGGCATGTATAACTTATTTATATATTTCTGTTAATTCTTTCTGAAGGCAATT
TCTATGCTGGAGAGTCTTAGCTTGCCTACTATAAATAACACTGTGGTATCACAGAGGATTATGCAATATT
GACCAGATAAAAATACCATGAAGATGTTGATATTGTACAAAAAGAACTCTAACTCTTTATATAGGAAGTC
GTTCAATGTTGTCAGTTATGACTGTTTTTTAAAACAAAGAACTAACTGAGGTCAAGGGCTAGGAGAATAT
TCAGGAATGAGTTCACTAGAAACATGATGCCTTCCATAGTCTCCAAATAATCATATTGGAATTAGAAAGG
AAGTAGCTGGCAGAGCTGTGCCTGTTGATAAAATCAATCCTTAATCACTTTTTCCCCCAACAGGTGCAGT
TTTGCCAAGGAGTGCTAAAGAACTTAGATGTCAGTGCATAAAGACATACTCCAAACCTTTCCACCCCAAA
TTTATCAAAGAACTGAGAGTGATTGAGAGTGGACCACACTGCGCCAACACAGAAATTATGTAAGTACTTT
AAAAAAGATTAGATATTTTGTTTTAGCAAACTTAAAATTAAGGAAGGTGGAAATATTTAGGAAAGTTCCA
GGTGTTAGGATTACAGTAGTAAATGAAACAAAACAAAATAAAAATATTTGTCTACATGACATTTAAATAT
GGTAGCTTCCACAACTACTATAAATGTTATTTTGGACTTAGACTTTATGCCTGACTTAAGGAATCATGAT
TTGAATGCAAAAACTAAATATTAATCTGAACCATTTCTTTCTTATTTCAGTGTAAAGCTTTCTGATGGAA
GAGAGCTCTGTCTGGACCCCAAGGAAAACTGGGTGCAGAGGGTTGTGGAGAAGTTTTTGAAGAGGTAAGT
TATATATTTTTTAATTTAAATTTTTCATTTATCCTGAGACATATAATCCAAAGTCAGCCTATAAATTTCT
TTCTGTTGCTAAAAATCGTCATTAGGTATCTGCCTTTTTGGTTAAAAAAAAAAGGAATAGCATCAATAGT
GAGTTTGTTGTACTCATGACCAGAAAGACCATACATAGTTTGCCCAGGAAATTCTGGGTTTAAGCTTGTG
TCCTATACTCTTAGTAAAGTTCTTTGTCACTCCCAGTAGTGTCCTATTTTAGATGATAATTTCTTTGATC
TCCCTATTTATAGTTGAGAATATAGAGCATTTCTAACACATGAATGTCAAAGACTATATTGACTTTTCAA
GAACCCTACTTTCCTTCTTATTAAACATAGCTCATCTTTATATTTTTAATTTTATTTTAGGGCTGAGAAT
TCATAAAAAAATTCATTCTCTGTGGTATCCAAGAATCAGTGAAGATGCCAGTGAAACTTCAAGCAAATCT
ACTTCAACACTTCATGTATTGTGTGGGTCTGTTGTAGGGTTGCCAGATGCAATACAAGATTCCTGGTTAA
ATTTGAATTTCAGTAAACAATGAATAGTTTTTCATTGTACCATGAAATATCCAGAACATACTTATATGTA
AAGTATTATTTATTTGAATCTACAAAAAACAACAAATAATTTTTAAATATAAGGATTTTCCTAGATATTG
CACGGGAGAATATACAAATAGCAAAATTGAGGCCAAGGGCCAAGAGAATATCCGAACTTTAATTTCAGGA
ATTGAATGGGTTTGCTAGAATGTGATATTTGAAGCATCACATAAAAATGATGGGACAATAAATTTTGCCA
TAAAGTCAAATTTAGCTGGAAATCCTGGATTTTTTTCTGTTAAATCTGGCAACCCTAGTCTGCTAGCCAG
GATCCACAAGTCCTTGTTCCACTGTGCCTTGGTTTCTCCTTTATTTCTAAGTGGAAAAAGTATTAGCCAC
CATCTTACCTCACAGTGATGTTGTGAGGACATGTGGAAGCACTTTAAGTTTTTTCATCATAACATAAATT
ATTTTCAAGTGTAACTTATTAACCTATTTATTATTTATGTATTTATTTAAGCATCAAATATTTGTGCAAG
AATTTGGAAAAATAGAAGATGAATCATTGATTGAATAGTTATAAAGATGTTATAGTAAATTTATTTTATT
TTAGATATTAAATGATGTTTTATTAGATAAATTTCAATCAGGGTTTTTAGATTAAACAAACAAACAATTG
GGTACCCAGTTAAATTTTCATTTCAGATAAACAACAAATAATTTTTTAGTATAAGTACATTATTGTTTAT
CTGAAATTTTAATTGAACTAACAATCCTAGTTTGATACTCCCAGTCTTGTCATTGCCAGCTGTGTTGGTA
GTGCTGTGTTGAATTACGGAATAATGAGTTAGAACTATTAAAACAGCCAAAACTCCACAGTCAATATTAG
TAATTTCTTGCTGGTTGAAACTTGTTTATTATGTACAAATAGATTCTTATAATATTATTTAAATGACTGC
ATTTTTAAATACAAGGCTTTATATTTTTAACTTTAAGATGTTTTTATGTGCTCTCCAAATTTTTTTTACT
GTTTCTGATTGTATGGAAATATAAAAGTAAATATGAAACATTTAAAATATAATTTGTTGTCAAAGTAA
|
| Protein Name |
IL8_HUMAN |
| Length |
99 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-JUL-1989 |
| Definition |
RecName: Full=Interleukin-8; Short=IL-8; AltName: Full=C-X-C motif chemokine 8; AltName: Full=Chemokine (C-X-C motif) ligand 8; AltName: Full=Emoctakin; AltName: Full=Granulocyte chemotactic protein 1; Short=GCP-1; AltName: Full=Monocyte-derived neutrophil chemotactic factor; Short=MDNCF; AltName: Full=Monocyte-derived neutrophil-activating peptide; Short=MONAP; AltName: Full=Neutrophil-activating protein 1; Short=NAP-1; AltName: Full=Protein 3-10C; AltName: Full=T-cell chemotactic factor; Contains: RecName: Full=MDNCF-a; AltName: Full=GCP/IL-8 protein IV; AltName: Full=IL8/NAP1 form I; Contains: RecName: Full=Interleukin-8; AltName: Full=(Ala-IL-8)77; AltName: Full=GCP/IL-8 protein II; AltName: Full=IL-8(1-77); AltName: Full=IL8/NAP1 form II; AltName: Full=MDNCF-b; Contains: RecName: Full=IL-8(5-77); Contains: RecName: Full=IL-8(6-77); AltName: Full=(Ser-IL-8)72; AltName: Full=GCP/IL-8 protein I; AltName: Full=IL8/NAP1 form III; AltName: Full=Lymphocyte-derived neutrophil-activating factor; Short=LYNAP; AltName: Full=MDNCF-c; AltName: Full=Neutrophil-activating factor; Short=NAF; Contains: RecName: Full=IL-8(7-77); AltName: Full=GCP/IL-8 protein V; AltName: Full=IL8/NAP1 form IV; Contains: RecName: Full=IL-8(8-77); AltName: Full=GCP/IL-8 protein VI; AltName: Full=IL8/NAP1 form V; Contains: RecName: Full=IL-8(9-77); AltName: Full=GCP/IL-8 protein III; AltName: Full=IL8/NAP1 form VI; Flags: Precursor |
| Primary Accession |
P10145 |
| Accession Version |
P10145.1 |
| Other SeqIDs |
sp|P10145.1|IL8_HUMAN,gi|124359 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On or before May 6, 2009 this sequence version replaced gi:74720272, gi:74720273, gi:74720274, gi:74720183, gi:74738943, gi:74724749, gi:88001.; [FUNCTION] Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:7636208, PubMed:18692776). Also plays an important role in neutrophil activation (PubMed:9623510, PubMed:2145175). Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells (PubMed:1840701, PubMed:1891716). G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways (PubMed:8662698, PubMed:11971003). {ECO:0000269|PubMed:11971003, ECO:0000269|PubMed:11978786, ECO:0000269|PubMed:1840701, ECO:0000269|PubMed:18692776, ECO:0000269|PubMed:1891716, ECO:0000269|PubMed:2145175, ECO:0000269|PubMed:2212672, ECO:0000269|PubMed:7636208, ECO:0000269|PubMed:8662698, ECO:0000269|PubMed:9623510}.; [SUBUNIT] Homodimer (PubMed:31235521). Dimer formation is disrupted by tick evasin-3 (PubMed:31235521). Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans. {ECO:0000269|PubMed:24501198, ECO:0000269|PubMed:31235521}.; [INTERACTION] P10145; P25025: CXCR2; NbExp=3; IntAct=EBI-3917999, EBI-2835281; P10145; P02776: PF4; NbExp=2; IntAct=EBI-3917999, EBI-2565740; P10145; P98066: TNFAIP6; NbExp=15; IntAct=EBI-3917999, EBI-11700693; P10145; P9WGV3: ahcY; Xeno; NbExp=3; IntAct=EBI-3917999, EBI-11740468; P10145; P9WMN3: glmU; Xeno; NbExp=3; IntAct=EBI-3917999, EBI-11740532; P10145; Q6MX51: Rv0296c; Xeno; NbExp=3; IntAct=EBI-3917999, EBI-11740572.; [SUBCELLULAR LOCATION] Secreted.; [INDUCTION] By ER stress in a DDIT3/CHOP-dependent manner. {ECO:0000269|PubMed:20829347}.; [PTM] Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. {ECO:0000269|PubMed:11023497, ECO:0000269|PubMed:11978786, ECO:0000269|PubMed:2145175, ECO:0000269|PubMed:2212672, ECO:0000269|PubMed:2523801, ECO:0000269|PubMed:2648135}.; [PTM] Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. {ECO:0000269|PubMed:18710930, ECO:0000269|PubMed:19608678}.; [PTM] (Microbial infection) Cleaved by group A Streptococcus protease SpyCEP; leading to impaired neutrophil endothelial transmigration and thus increased virulence. {ECO:0000269|PubMed:18692776}.; [SIMILARITY] Belongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.; [SEQUENCE CAUTION] Sequence=AAK00048.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=Interleukin-8 entry; URL='https://en.wikipedia.org/wiki/Interleukin_8'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/il8/'. |
| Source Db |
UniProtKB: locus IL8_HUMAN, accession P10145;; class: standard.; extra accessions:B2R4L8,Q6FGF6,Q6LAE6,Q96RG6,Q9C077,Q9UCE1,Q9UCR8,Q9UCR9,Q9UCS0; created: Jul 1, 1989.; sequence updated: Jul 1, 1989.; annotation updated: Oct 12, 2022.; xrefs: M17017.1, AAA35611.1, Y00787.1, CAA68742.1, M28130.1, AAA59158.1, M26383.1, AAA36323.1, D14283.1, BAA03245.1, BT007067.1, AAP35730.1, AK311874.1, BAG34815.1, CR542151.1, CAG46948.1, AF385628.2, AAK60276.1, CH471057.1, EAX05688.1, BC013615.1, AAH13615.1, Z11686.1, CAA77745.1, AF043337.1, AAK00048.1, A37034, NP_000575.1, 1ICW_A, 1ICW_B, 1IKL_A, 1IKM_A, 1IL8_A, 1IL8_B, 1ILP_A, 1ILP_B, 1ILQ_A, 1ILQ_B, 1QE6_A, 1QE6_B, 1QE6_C, 1QE6_D, 1ROD_A, 1ROD_B, 2IL8_A, 2IL8_B, 3IL8_A, 4XDX_A, 5D14_A, 5WDZ_A, 6LFM_D, 6LFM_E, 6LFO_D, 6N2U_A, 6WZM_E, 6WZM_F, 6XMN_A; xrefs (non-sequence databases): CCDS:CCDS34005.1, PDBsum:1ICW, PDBsum:1IKL, PDBsum:1IKM, PDBsum:1IL8, PDBsum:1ILP, PDBsum:1ILQ, PDBsum:1QE6, PDBsum:1ROD, PDBsum:2IL8, PDBsum:3IL8, PDBsum:4XDX, PDBsum:5D14, PDBsum:5WDZ, PDBsum:6LFM, PDBsum:6LFO, PDBsum:6N2U, PDBsum:6WZM, PDBsum:6XMN, AlphaFoldDB:P10145, BMRB:P10145, SMR:P10145, BioGRID:109790, DIP:DIP-3778N, IntAct:P10145, STRING:9606.ENSP00000306512, BindingDB:P10145, ChEMBL:CHEMBL2157, DrugBank:DB05434, DrugBank:DB05484, DrugBank:DB05855, DrugBank:DB06083, DrugCentral:P10145, BioMuta:CXCL8, DMDM:124359, EPD:P10145, MassIVE:P10145, PaxDb:P10145, PeptideAtlas:P10145, PRIDE:P10145, ABCD:P10145, Antibodypedia:13311, DNASU:3576, Ensembl:ENST00000307407.8, Ensembl:ENSP00000306512.3, Ensembl:ENSG00000169429.12, GeneID:3576, KEGG:hsa:3576, MANE-Select:ENST00000307407.8, UCSC:uc003hhe.3, CTD:3576, DisGeNET:3576, GeneCards:CXCL8, HGNC:6025, HPA:ENSG00000169429, MIM:146930, neXtProt:NX_P10145, OpenTargets:ENSG00000169429, PharmGKB:PA29841, VEuPathDB:HostDB:ENSG00000169429, eggNOG:ENOG502S7MM, GeneTree:ENSGT00940000160757, InParanoid:P10145, OMA:IGTELRC, OrthoDB:1471901at2759, PhylomeDB:P10145, TreeFam:TF333433, PathwayCommons:P10145, Reactome:R-HSA-2559582, Reactome:R-HSA-375276, Reactome:R-HSA-380108, Reactome:R-HSA-380994, Reactome:R-HSA-418594, Reactome:R-HSA-6783783, Reactome:R-HSA-6785807, SignaLink:P10145, SIGNOR:P10145, BioGRID-ORCS:3576, ChiTaRS:CXCL8, EvolutionaryTrace:P10145, GeneWiki:Interleukin_8, GenomeRNAi:3576, Pharos:P10145, PRO:PR:P10145, Proteomes:UP000005640, RNAct:P10145, Bgee:ENSG00000169429, ExpressionAtlas:P10145, Genevisible:P10145, GO:0005576, GO:0005615, GO:0008009, GO:0045236, GO:0008201, GO:0005153, GO:0001525, GO:0061844, GO:0019722, GO:0044344, GO:0071347, GO:0071222, GO:0071356, GO:0070098, GO:0006935, GO:0048566, GO:0007186, GO:0050930, GO:0006954, GO:0035556, GO:0031640, GO:0060354, GO:0008285, GO:0045744, GO:0010629, GO:0042119, GO:0030593, GO:0045766, GO:0031328, GO:0010628, GO:0090023, GO:0031623, GO:0030155, GO:2000535, GO:0045091, GO:0034976, GO:0002237, GO:0007165, CDD:cd00273, InterPro:IPR001089, InterPro:IPR018048, InterPro:IPR001811, InterPro:IPR033899, InterPro:IPR028469, InterPro:IPR036048, PANTHER:PTHR10179, PANTHER:PTHR10179:SF42, Pfam:PF00048, PRINTS:PR00437, SMART:SM00199, SUPFAM:SSF54117, PROSITE:PS00471 |
| Sequence |
mtsklavallaaflisaalcegavlprsakelrcqciktyskpfhpkfikelrviesgphcanteiivklsdgrelcldpkenwvqrvvekflkraens |
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