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| Record Information |
| Record ID |
101 |
| Pubmed ID |
28991404 |
| SNP |
|
| Gene ID |
6347 |
| Protein ID |
P13500 |
| Vaccine Adverse Events |
moderate myalgia, moderate injection site pain |
| Vaccine |
inactivated trivalent influenza vaccine (TIV) |
| Gene Name |
CCL2 |
| Official Symbol |
C-C motif chemokine ligand 2 [Homo sapiens (human)] |
| Aliases |
GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF |
| Other Designations |
C-C motif chemokine 2; chemokine (C-C motif) ligand 2; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; monocyte chemotactic protein 1; monocyte secretory protein JE; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small-inducible cytokine A2 |
| Chromosome |
17 |
| Location |
17q12 |
| Annotation |
Chromosome 17 NC_000017.11 (34255285..34257203) |
| MIM |
158105 |
| DNA Sequence |
>NC_000017.11:34255285-34257203 Homo sapiens chromosome 17, GRCh38.p14 Primary Assembly
GAGAGGCTGAGACTAACCCAGAAACATCCAATTCTCAAACTGAAGCTCGCACTCTCGCCTCCAGCATGAA
AGTCTCTGCCGCCCTTCTGTGCCTGCTGCTCATAGCAGCCACCTTCATTCCCCAAGGGCTCGCTCAGCCA
GGTAAGGCCCCCTCTTCTTCTCCTTGAACCACATTGTCTTCTCTCTGAGTTATCATGGACCATCCAAGCA
GACGTGGTACCCACAGTCTTGCTTTAACGCTACTTTTCCAAGATAAGGTGACTCAGAAAAGGACAAGGGG
TGAGCCCAACCACACAGCTGCTGCTCGGCAGAGCCTGAACTAGAATTCCAGCTGTGAACCCCAAATCCAG
CTCCTTCCAGGATTCCAGCTCTGGGAACACACTCAGCGCAGTTACTCCCCCAGCTGCTTCCAGCAGAGTT
TGGGGATCAGGGTAATCAAAGAGAGGGTGGGTGTGTAGGCTGTTTCCAGACACGCTGGAGACCCAGAATC
TGGTCTGTGCTTCATTCACCTTAGCTTCCAGAGACGGTGACTCTGCAGAGGTAATGAGTATCAGGGAAAC
TCATGACCAGGCATAGCCTATTCAGAGTCTAAAAGGAGGCTCATAGTGGGGCTCCCCAGCTGATCTTCCC
TGGTGCTGATCATCTGGATTATTGGTCCGTCTTAATGACACTTGTAGGCATTATCTAGCTTTAACAGCTC
CTCCTTCTCTCTGTCCATTATCAATGTTATATACCCATTTTACAGCATAGGAAACTGAGTCATTGGGTCA
AAGATCACATTCTAGCTCTGAGGTATAGGCAGAAGCACTGGGATTTAATGAGCTCTTTGTCTTCTCCTGC
CTGCCTTTTGCTTTTTCCTCATGACTCTTTTCTGCTCTTAAGATCAGAATAATCCAGTTCATCCTAAAAT
GCTTTTTCTTTGTGGTTTATTTTCCAGATGCAATCAATGCCCCAGTCACCTGCTGTTATAACTTCACCAA
TAGGAAGATCTCAGTGCAGAGGCTCGCGAGCTATAGAAGAATCACCAGCAGCAAGTGTCCCAAAGAAGCT
GTGATGTGAGTTCAGCACACCAACCTTCCCTGGCCTGAAGTTCTTCCTTGTGGAGCAAGGGACAAGCCTC
ATAAACCTAGAGTCAGAGAGTGCACTATTTAACTTAATGTACAAAGGTTCCCAATGGGAAAACTGAGGCA
CCAAGGGAAAAAGTGAACCCCAACATCACTCTCCACCTGGGTGCCTATTCAGAACACCCCAATTTCTTTA
GCTTGAAGTCAGGATGGCTCCACCTGGACACCTATAGGAGCAGTTTGCCCTGGGTTCCCTCCTTCCACCT
GCGTTCCTCCTCTAGCTCCCATGGCAGCCCTTTGGTGCAGAATGGGCTGCACTTCTAGACCAAAACTGCA
AAGGAACTTCATCTAACTCTGTCCTCCCTCCCCACAGCTTCAAGACCATTGTGGCCAAGGAGATCTGTGC
TGACCCCAAGCAGAAGTGGGTTCAGGATTCCATGGACCACCTGGACAAGCAAACCCAAACTCCGAAGACT
TGAACACTCACTCCACAACCCAAGAATCTGCAGCTAACTTATTTTCCCCTAGCTTTCCCCAGACACCCTG
TTTTATTTTATTATAATGAATTTTGTTTGTTGATGTGAAACATTATGCCTTAAGTAATGTTAATTCTTAT
TTAAGTTATTGATGTTTTAAGTTTATCTTTCATGGTACTAGTGTTTTTTAGATACAGAGACTTGGGGAAA
TTGCTTTTCCTCTTGAACCACAGTTCTACCCCTGGGATGTTTTGAGGGTCTTTGCAAGAATCATTAATAC
AAAGAATTTTTTTTAACATTCCAATGCATTGCTAAAATATTATTGTGGAAATGAATATTTTGTAACTATT
ACACCAAATAAATATATTTTTGTACAAAA
|
| Protein Name |
CCL2_HUMAN |
| Length |
99 |
| Moltype |
AA |
| Topology |
linear |
| Division |
PRI |
| Update Date |
12-OCT-2022 |
| Create Date |
01-JAN-1990 |
| Definition |
RecName: Full=C-C motif chemokine 2; AltName: Full=HC11; AltName: Full=Monocyte chemoattractant protein 1; AltName: Full=Monocyte chemotactic and activating factor; Short=MCAF; AltName: Full=Monocyte chemotactic protein 1; Short=MCP-1; AltName: Full=Monocyte secretory protein JE; AltName: Full=Small-inducible cytokine A2; Flags: Precursor |
| Primary Accession |
P13500 |
| Accession Version |
P13500.1 |
| Other SeqIDs |
sp|P13500.1|CCL2_HUMAN,gi|126842 |
| Organism |
Homo sapiens |
| Taxonomy |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Comment |
On Mar 15, 2005 this sequence version replaced gi:280830.; [FUNCTION] Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690). {ECO:0000269|PubMed:10529171, ECO:0000269|PubMed:10587439, ECO:0000269|PubMed:8107690, ECO:0000269|PubMed:8195247, ECO:0000269|PubMed:8627182, ECO:0000269|PubMed:9792674, ECO:0000269|PubMed:9837883}.; [SUBUNIT] Monomer or homodimer; in equilibrium (PubMed:8898111, PubMed:9837883, PubMed:15033992, PubMed:8989326). Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans (PubMed:9792674). Interacts with TNFAIP6 (via Link domain). {ECO:0000269|PubMed:15033992, ECO:0000269|PubMed:27044744, ECO:0000269|PubMed:8898111, ECO:0000269|PubMed:8989326, ECO:0000269|PubMed:9792674, ECO:0000269|PubMed:9837883}.; [INTERACTION] P13500; P13501: CCL5; NbExp=2; IntAct=EBI-1034732, EBI-2848366; P13500; P80075: CCL8; NbExp=2; IntAct=EBI-1034732, EBI-16803830; P13500; P02776: PF4; NbExp=2; IntAct=EBI-1034732, EBI-2565740; P13500; P78317: RNF4; NbExp=3; IntAct=EBI-1034732, EBI-2340927; P13500; Q9Y320: TMX2; NbExp=3; IntAct=EBI-1034732, EBI-6447886; P13500; Q2F862; Xeno; NbExp=5; IntAct=EBI-1034732, EBI-16161937; PRO_0000005146; P98066: TNFAIP6; NbExp=2; IntAct=EBI-11711396, EBI-11700693.; [SUBCELLULAR LOCATION] Secreted {ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:2513477}.; [TISSUE SPECIFICITY] Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) (PubMed:23765988). Expressed in monocytes (PubMed:2513477). {ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:2513477}.; [INDUCTION] Up-regulated upon hypertonic conditions (PubMed:23233732). In pancreatic islets, secretion is stimulated by IL1B (PubMed:23955712). {ECO:0000269|PubMed:23233732, ECO:0000269|PubMed:23955712}.; [PTM] Processing at the N-terminus can regulate receptor and target cell selectivity (PubMed:8627182). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (PubMed:8627182). {ECO:0000269|PubMed:8627182}.; [PTM] N-Glycosylated. {ECO:0000269|PubMed:2513477}.; [POLYMORPHISM] Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948]. {ECO:0000269|PubMed:16352737}.; [SIMILARITY] Belongs to the intercrine beta (chemokine CC) family. {ECO:0000305}.; [WEB RESOURCE] Name=Wikipedia; Note=CCL2 entry; URL='https://en.wikipedia.org/wiki/CCL2'.; [WEB RESOURCE] Name=SeattleSNPs; URL='http://pga.gs.washington.edu/data/scya2/'. |
| Source Db |
UniProtKB: locus CCL2_HUMAN, accession P13500;; class: standard.; extra accessions:B2R4V3,Q9UDF3; created: Jan 1, 1990.; sequence updated: Jan 1, 1990.; annotation updated: Oct 12, 2022.; xrefs: M24545.1, AAA18164.1, M28225.1, AAA60308.1, M28223.1, M28224.1, M28226.1, AAA60309.1, M31626.1, AAA36330.1, M30816.1, M31625.1, X14768.1, CAA32876.1, M37719.1, AAA18102.1, S71513.1, AAB20651.1, S69738.1, AAB29926.1, Y18933.1, CAC14049.1, A17786.1, CAA01352.1, BT007329.1, AAP35993.1, AF519531.1, AAM54046.1, AK311960.1, BAG34900.1, CH471147.2, EAW80212.1, BC009716.1, AAH09716.1, A60299, NP_002973.1, 1DOK_A, 1DOK_B, 1DOL_A, 1DOM_A, 1DOM_B, 1DON_A, 1DON_B, 1ML0_D, 2BDN_A, 2NZ1_D, 2NZ1_E, 2NZ1_Y, 3IFD_A, 4DN4_M, 4R8I_A, 4ZK9_B, 7SO0_B; xrefs (non-sequence databases): CCDS:CCDS11277.1, PDBsum:1DOK, PDBsum:1DOL, PDBsum:1DOM, PDBsum:1DON, PDBsum:1ML0, PDBsum:2BDN, PDBsum:2NZ1, PDBsum:3IFD, PDBsum:4DN4, PDBsum:4R8I, PDBsum:4ZK9, PDBsum:7SO0, AlphaFoldDB:P13500, SMR:P13500, BioGRID:112251, DIP:DIP-5838N, IntAct:P13500, STRING:9606.ENSP00000225831, BindingDB:P13500, ChEMBL:CHEMBL1649052, DrugBank:DB09301, DrugBank:DB01406, DrugBank:DB01055, DrugCentral:P13500, GlyGen:P13500, BioMuta:CCL2, DMDM:126842, MassIVE:P13500, PaxDb:P13500, PeptideAtlas:P13500, PRIDE:P13500, ProteomicsDB:52921, ABCD:P13500, Antibodypedia:4427, DNASU:6347, Ensembl:ENST00000225831.4, Ensembl:ENSP00000225831.4, Ensembl:ENSG00000108691.10, GeneID:6347, KEGG:hsa:6347, MANE-Select:ENST00000225831.4, UCSC:uc002hhy.4, CTD:6347, DisGeNET:6347, GeneCards:CCL2, HGNC:10618, HPA:ENSG00000108691, MalaCards:CCL2, MIM:158105, MIM:607948, neXtProt:NX_P13500, OpenTargets:ENSG00000108691, PharmGKB:PA130413151, VEuPathDB:HostDB:ENSG00000108691, eggNOG:ENOG502S6ZP, GeneTree:ENSGT01060000248576, HOGENOM:CLU_141716_1_0_1, InParanoid:P13500, OMA:PITCCYT, OrthoDB:1575018at2759, PhylomeDB:P13500, TreeFam:TF334888, PathwayCommons:P13500, Reactome:R-HSA-380108, Reactome:R-HSA-380994, Reactome:R-HSA-6783783, Reactome:R-HSA-6785807, SignaLink:P13500, SIGNOR:P13500, BioGRID-ORCS:6347, ChiTaRS:CCL2, EvolutionaryTrace:P13500, GeneWiki:CCL2, GenomeRNAi:6347, Pharos:P13500, PRO:PR:P13500, Proteomes:UP000005640, RNAct:P13500, Bgee:ENSG00000108691, ExpressionAtlas:P13500, Genevisible:P13500, GO:0005576, GO:0005615, GO:0048020, GO:0031727, GO:0008009, GO:0004672, GO:0005102, GO:0001525, GO:0009887, GO:0043615, GO:0007155, GO:0007166, GO:0019725, GO:0044344, GO:0071346, GO:0071347, GO:0071222, GO:0071407, GO:0071356, GO:0070098, GO:0006935, GO:0019221, GO:0007010, GO:0048245, GO:0007186, GO:0007187, GO:0035684, GO:0006959, GO:0006954, GO:0031663, GO:0048247, GO:0048246, GO:0000165, GO:0002548, GO:2000134, GO:0034351, GO:2000502, GO:0043524, GO:1905563, GO:0030593, GO:2000427, GO:0090280, GO:2000353, GO:0070374, GO:0043547, GO:0051770, GO:1904783, GO:0051968, GO:0050870, GO:0043491, GO:0006468, GO:0007259, GO:0008360, GO:0009617, GO:0019233, GO:0007165, GO:0019079, InterPro:IPR039809, InterPro:IPR000827, InterPro:IPR001811, InterPro:IPR036048, PANTHER:PTHR12015, Pfam:PF00048, SMART:SM00199, SUPFAM:SSF54117, PROSITE:PS00472 |
| Sequence |
mkvsaallcllliaatfipqglaqpdainapvtccynftnrkisvqrlasyrritsskcpkeavifktivakeicadpkqkwvqdsmdhldkqtqtpkt |
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