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Record Information
Record ID 100
Pubmed ID 33057068
SNP
Gene ID 2348
Protein ID P15328
Vaccine Adverse Events injection site reactions, arthralgias, pruritus, myalgias
Vaccine dendritic cell vaccine
Gene Name FOLR1
Official Symbol folate receptor alpha [Homo sapiens (human)]
Aliases FBP, FOLR, FRalpha, NCFTD
Other Designations folate receptor alpha; FR-alpha; KB cells FBP; adult folate-binding protein; folate binding protein; folate receptor 1 (adult); folate receptor, adult; ovarian tumor-associated antigen MOv18
Chromosome 11
Location 11q13.4
Annotation Chromosome 11 NC_000011.10 (72189709..72196323)
MIM 136430
DNA Sequence >NC_000011.10:72189709-72196323 Homo sapiens chromosome 11, GRCh38.p14 Primary Assembly GTAGAGCAGAGCAGAAGCCTGAGCCAGACGGAGAGCCACCTCCTCTCCCAGGTATGTGACACTCCCCATC CCCCTTCAGAGGCCACACACCCTATGGCATTCCCACCATGTGTTAAGGATTTTCTGAACTGGAAGGGCCC TCTGTTTGCCTGAAGGCCAGAGAATCTTGAAGTGGAGACTGAGGCCCAGACCAGAGTGTGGCCTGCTCAA GGTTAAACGACAAGTTAGTGTTCATCCCCCTGAACTAGTACCTGGGCTCTAGCCCTTCAGTCCAGAGCTG AGTTCTCAGCTCTTCTAGTCTGGGGCCCCAAGGTTGGGTGTGGGGGTCATGATTGTTGGTGGGGAGGGGT CACAGCTGGACTAAGACCTGAAGGTGAGACTAGGCAGGTGGGAAAGGAGCTTGCAGAGTGATGCTGCTCA AAAGGACAGGAAGAGAGCCTGGCTTCAGAAGCAGCCACAGCAAGAGAGACTACTGACTGAACAGGTGGGC TCCACTGGGGGCTGGGGAAAGGATTTTCTCAGCCCCCATCCCCAGCACTGTGTGTTGGCCGCACCCATGA GAGCCTCAGCACTCTGAAGGTGCAGGGGGCAAAGGCCAAAAGAGCTCTGGCCTGAACTTGGGTGGTCCCT ACTGTGTGACTTGGGGCATGGCCCTCATCTGTGCTGAAATGATTCCACAAAGATTAAACTGGCTATCATT TGTTGATTTCCCCCTTCTTACATTTAATCCTTGCAGGAGAAAGCTAAGCCTCAAGATAGTTTGCTTCTCT TTCCCCCAAGGCCAAGGAGAAGGTGGAGTGAGGGCTGGGGTCGGGACAGGTTGAACGGGAACCCTGTGCT CTAAACAGTTAGGGTTTGTTCCCGCAGGAACTGAACCCAAAGGATCACCTGGTATTCCCTGAGAGTACAG ATTTCTCCGGCGTGGCCCTCAAGGTTAGTGAGTGAGCAGGTCCACAGGGGCATGATTGGATCCTGGAATG AATGAATCAACCATGAGAGAGTGAATGAACACTGGAATCAATAGAGTAGCAGAGTAATGGATTGTGGAGC AGGAAAGAGAGCTGCTGGGTGGGAATTCAATTCCAGGCTTATATGAGCCCTGCTGTGCAGTCGGCCTGGA GACAGCCCAGCTCAGGCCCTGCCTAGACCCCTGTCAAGGAGGCCCTGTCAAGAGGAGAGGAGGGGCAGCA CGGGGGCAAGGCAAGCTTGTGAGCGGGAAAGGCATGTCCACTTTAGCGACTGGTATGTGGAAGATGAGTT AGAGGAGACAGATGGAGAGAAGTCATAGGAAATAAATTCTGAGCATTTTAGGAGGGCCCAGACACCTGGT GTCCAGTGGAGTGAAGGAAACAGTCGCCTCCCAAAATTCAGTGTCTGAGGTCAAAGGATTGAAGTTCTGT GATGACCAAGGAGAAGCCAGCTCTGTGGTAGGGGGCACAGGAGCTCCCCAAGGCCCCAGGGCTGTCCAGC TGGCTGTCCCCTGCCAGCACCCATGTCCTGTGACCCCACCCCACCAAGATCCCATGGTTTCCGGGAAGGG CCTACTAAACTAGCTTGAGTGATGAGGCTAGAAAGGGGCTGGGACCAAGGTTTAAAAAGCAAAACAAACT AACAAAAACCACACTGCAGCCCCCCCAACTAAAACATTTTTATAAACTTTTTTTTTTTTTTTGAGATGGA GTCTCGCTCTGTCACCCAGGCTAGAGTGCAATGGCACAATCTTGGCTCACTGTAACCTCCACCTCCTGGA TTCAAGTGATTCTCCTGCCTCAGCCTCCCACGTAGCTGGGACTACAGGCACACGACACCGCACCCAGCTC ATTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTGGCCAGGCTGGTCTCAAACTTCTGACCTCAGG TGATCCACCCACCTCAGCCTTCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCAGCCCATTTTT GTAAACTTTTACAATGAAGTAATTTGGTGTCAAAATCTGACCTGAAAATTAATGTGAGTTTATGTATAGT TTTAATTTATCCCACTAGTGTAACTGTTTCACCCCAGAATATACACTTGATTATTGGGTATATGAAAATT ATATTTTCTTTGAATCACCTTTGATGAAATCCTAAAAAATTTTAACCCTGAAACATTTGAATAAGGCATT GTGGACCTATGGCAAACTCCTGGCTATTTCTGCATTTTGCCCAAATCCATCCTTGAATTATATCACCTGA ACCTCGTGACCACCTGGAGAAGGCAATGAGGCTCAAGCCAGGGAGGGGTGGTGTCTAATCCTACCTTTCA TTGGATCTGGGAAAACTGAGGGAGATGGGGGCAGGGCTCTATCTGCCCCAGGCTTCCGTCCAGGCCCCAC CCTCCTGGAGCCCTGCACACAACTTAAGGCCCCACCTCCGCATTCCTTGGTGCCACTGACCACAGCTCTT TCTTCAGGGACAGACATGGCTCAGCGGATGACAACACAGCTGCTGCTCCTTCTAGTGTGGGTGGCTGTAG TAGGGGAGGCTCAGACAAGGATTGCATGGGCCAGGACTGAGCTTCTCAATGTCTGCATGAACGCCAAGCA CCACAAGGAAAAGCCAGGCCCCGAGGACAAGTTGCATGAGCAGGTGGGCCAGGGGGTGATCTGGGGTGGT GAGGGACTGGCTCAGGAAGAGGAAACGAGGACATGGAAATGCCAAACCCCATTCACTGGTGAACTGAAGT GGAGGAGCCCTTCAGTTTGCATTAATATGGGTGACTATTTCACAGACACTGTGCCAAATGTCGGTACAAT GCCAACAGTTCACCTTCTTGGTTGTTGAGTTTCCGCATTACAGAAATAAGGAAGCAGGCCCAAAGGAGAG CCTGGGAAATGAAGTTGGAGTGACCCATCCTGGGGTTGCTTGATTTAGGGATTTAGACTGGGAATGACTC CTCCAAAGATCTGAGGGAAGAAACTGCACACTGTGCATAGTGGCCTCTTTTCTGCCAGCCCTAAACAGCT CAAGAAGGGAGAGTCTCTCACATTATGAGGCTGTGTGCAAAGCATTCTTTTTTTTTTTTCCTGAGACAAA GTCTCCATATGTTGCCCAGGCTGGTCTCAAATTCCTGGACTCAAGTGATCCTCCCACCTCAGCCTCCCAA AGTGTGGGATTACAGAAATGAGCCGTACGCCCTCCTGAAGCATCTTGGTTCATGCATCTCGCAAAACTTT GGGCTGTGTCTCTCGACCACATTGGACCTGAGGTCTCCCTATAACATTTATTTTGCTACCACCCCTTTAA TATCCTGAACATGATGATATAACTAAAGAAAAAGCAGAGGAAAAGTAATTTGTAGGCCAGGTGTTACGGC TCACGCCTGTAATCCCAACACTGTGGGATGTCGAGATGGGCAGATCACTTGAGCTCAGGAGTTCGAGACC AGCCTGGGCAAGATGGCAAAACCCCATCTCTACTAAAAAATAAAAAAAATTAGTCAGGTGTGGTGGCACA TGCCTGCAGTCCCAGCTACTCAGGAGGCTGAGGTGGGCAGGTCAGTTGAGCCCAGGAGGCAGAGATTGTA GATCGTGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACCTTGTCAAAAGAAAGAAAGAACGAAAAAA AGAAAGAAAGGAAGGAAGGAAGGGGAGGAAGGAAAGGGAGGGAGGAAAGGGAGGGAGGAAAGGGAGGGAG GCAAGGGAGAGAAACTTGTAATACGCATTTCTTTTTTTTTTTCTTGAGATAGAGTTTTGCTCTTGTTGCC CAGGGTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCCT GCCTCAGCCTCCTGAGTAGGCACACGCCACCACACCCAGCTAATTTTTTGTTTGTTTGTTTGTTTTGTTT GTTGGTATTTTTAGTAGAGATGGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTCACCTCATA ATCCGCCCCTCTTGGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACTGCGCCCGGCCTTAAGTGCA CATTTTATTTATTTATTTATTTATTTATTTATTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGC AGTGGCACAATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTTGGCCTCCA GAGTAGCTGGGACTATAGGCACCTGCCACCATGCCTAGCTAATTTTTGTATTTTTAGTAGAAATGGGGTT TTGCCATGTTGGCCAGGCTGGTCTCCATTCTTGACCTTAAGTGATCTGTCCACCTCCACCTCCCAAAGTG CTGGGATTACAGGCACTATGTGAGCCACTGTGCCGGCCCACATTTTAATATTTAGCTTGTCAGCCTTAAG TAATGAGATTCAGGAAGCTTGAGGATAGGCACACAGGAGCATAGTTTCAAGTTGTCCTGAATTTTGCAGC CATCACAAGTTAGTTTTTAAGGAAAAAGATTAGTTCCTAAGTTGTTTCTCAATAACTTATAATAAAATAA CATCCACAATTGATTGGCTATACATTGTTTTTTTGTATCACAAATTCCACAAACAGATAATGGGTGAGGC AGCTAGTCAGGGACAAAACACTTCCCAAGTAGCTGGGATTACAGGTGTCCGCCACCACACTTGGCTAGTT TTTTGTTTGTTTATTTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCATGATCTC GGCTCACTGCAAGCTCCACCTGCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACT ACAGGTGCCAGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGC CAGGATGGTCTTGATCTCTTAGCCTCGTGATCCACCCGCCTCGGCCTCCCAAAATGCTGGGATTACAGGC GTGAGCCACCGCACCCGGCCTAATTTTTATATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCT GGTCTCAAACTCTTGATCTCAGGTGATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACACAAGTAA GCCACTGCACCCAGCCTGGGGTTACAATTTAAATTGCTTTTTTACCTTCAAATCTTTGACACCTCAGTGA GGCTTAATCTGACCGCACTATTACACTACAAGTCCCCATCCGTCTCTGCTTAATTTTTGTCCAAAGCAAA AATCAGGTGATGTGTTCATTGTTGTAACCCCAGTTTCTACAAAAGTACCTGGGTGAGAGTAAGTAGGATC TCAATAAAGGTTGAATTAACAAATTTTGTAATGACTGCAACTCCAGCAGGAGCTCCCTTTTGGGCTCCCA CTGTCTCTGACGGCCCTCTCCCCTAAAGAGGTCCCAATAGCAAGTATTTTCCTGGGTGACTTCCAGTGGG CTGGGGAATCAAGGACTAAGAGGGGAGACACTGCATGTGGAATATTCTGGCTGTGCTGGCTGTGCTGGCT GTGGACTGAGTCCTCTGTCTTCCCCCATCCAGTGTCGACCCTGGAGGAAGAATGCCTGCTGTTCTACCAA CACCAGCCAGGAAGCCCATAAGGATGTTTCCTACCTATATAGATTCAACTGGAACCACTGTGGAGAGATG GCACCTGCCTGCAAACGGCATTTCATCCAGGACACCTGCCTCTACGAGTGCTCCCCCAACTTGGGGCCCT GGATCCAGCAGGTATGCATGGCTTCCTGCAGGTACAAGACCTAGCGGAGCAGCTGAGCTTTCCAGGCATC TCTGCAGGCTGCAACCCCAGCTCCAGTTCTATTCGGGGCTGAGTTGCTGGGATTCTTGAACCTGAGCCCT TCTTTTGTATCAAAATCACCCAGGTGGATCAGAGCTGGCGCAAAGAGCGGGTACTGAACGTGCCCCTGTG CAAAGAGGACTGTGAGCAATGGTGGGAAGATTGTCGCACCTCCTACACCTGCAAGAGCAACTGGCACAAG GGCTGGAACTGGACTTCAGGTGAGGGCTGGGGTGGGCAGGAATGGAGGGATTTGGAAGTGGAGGTGTGTG GGTGTGGAACAGGTATGTGACAATTTGGAGTTGTAGGGCTGGCAGACCTCAAGATAGTTCCGGGCCCAGT GGCTAAAGGTCTTCCCTCCTCTCTACAGGGTTTAACAAGTGCGCAGTGGGAGCTGCCTGCCAACCTTTCC ATTTCTACTTCCCCACACCCACTGTTCTGTGCAATGAAATCTGGACTCACTCCTACAAGGTCAGCAACTA CAGCCGAGGGAGTGGCCGCTGCATCCAGATGTGGTTCGACCCAGCCCAGGGCAACCCCAATGAGGAGGTG GCGAGGTTCTATGCTGCAGCCATGAGTGGGGCTGGGCCCTGGGCAGCCTGGCCTTTCCTGCTTAGCCTGG CCCTAATGCTGCTGTGGCTGCTCAGCTGACCTCCTTTTACCTTCTGATACCTGGAAATCCCTGCCCTGTT CAGCCCCACAGCTCCCAACTATTTGGTTCCTGCTCCATGGTCGGGCCTCTGACAGCCACTTTGAATAAAC CAGACACCGCACATGTGTCTTGAGAATTATTTGGA
Protein Name FOLR1_HUMAN
Length 257
Moltype AA
Topology linear
Division PRI
Update Date 12-OCT-2022
Create Date 01-APR-1990
Definition RecName: Full=Folate receptor alpha; Short=FR-alpha; AltName: Full=Adult folate-binding protein; Short=FBP; AltName: Full=Folate receptor 1; AltName: Full=Folate receptor, adult; AltName: Full=KB cells FBP; AltName: Full=Ovarian tumor-associated antigen MOv18; Flags: Precursor
Primary Accession P15328
Accession Version P15328.3
Other SeqIDs sp|P15328.3|FOLR1_HUMAN,gi|544337
Organism Homo sapiens
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Comment On or before Mar 3, 2009 this sequence version replaced gi:74725862, gi:74738955, gi:74709704, gi:74734947, gi:321130, gi:120462.; [FUNCTION] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728, PubMed:19074442). Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728). Required for normal embryonic development and normal cell proliferation (By similarity). {ECO:0000250|UniProtKB:P35846, ECO:0000269|PubMed:19074442, ECO:0000269|PubMed:23851396, ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}.; [INTERACTION] P15328; Q8N357: SLC35F6; NbExp=3; IntAct=EBI-2556557, EBI-713484.; [SUBCELLULAR LOCATION] Cell membrane {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Apical cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Basolateral cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Secreted {ECO:0000305|PubMed:3476960}. Cytoplasmic vesicle {ECO:0000269|PubMed:8567728}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:8567728}. Endosome {ECO:0000269|PubMed:8567728}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. {ECO:0000269|PubMed:8567728}.; [TISSUE SPECIFICITY] Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:2768245, ECO:0000269|PubMed:9063895}.; [PTM] The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. {ECO:0000305|PubMed:3476960}.; [DISEASE] Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]: An autosomal recessive neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. {ECO:0000269|PubMed:19732866}. Note=The disease is caused by variants affecting the gene represented in this entry.; [SIMILARITY] Belongs to the folate receptor family. {ECO:0000305}.
Source Db UniProtKB: locus FOLR1_HUMAN, accession P15328;; class: standard.; extra accessions:Q53EW2,Q6FGT8,Q6LC90,Q9UCT2; created: Apr 1, 1990.; sequence updated: Jun 1, 1994.; annotation updated: Oct 12, 2022.; xrefs: J05013.1, AAA35823.1, M28099.1, AAA35822.1, X62753.1, CAA44610.1, U20391.1, AAB05827.1, U78793.1, AAB39751.1, U78794.1, AAB39752.1, BT007158.1, AAP35822.1, CR542019.1, CAG46816.1, AK223527.1, BAD97247.1, CH471076.1, EAW74848.1, BC002947.2, AAH02947.1, M25317.1, AAA74896.1, A45753, NP_000793.1, NP_057936.1, NP_057937.1, NP_057941.1, 4KM6_A, 4KM7_A, 4KM7_B, 4KMX_A, 4LRH_A, 4LRH_B, 4LRH_C, 4LRH_D, 4LRH_E, 4LRH_F, 4LRH_G, 4LRH_H, 5IZQ_A, 5IZQ_B, 5IZQ_C, 5IZQ_D, 5IZQ_E, 5IZQ_F, 5IZQ_G, 5IZQ_H; xrefs (non-sequence databases): CCDS:CCDS8211.1, PDBsum:4KM6, PDBsum:4KM7, PDBsum:4KMX, PDBsum:4LRH, PDBsum:5IZQ, AlphaFoldDB:P15328, SMR:P15328, BioGRID:108631, IntAct:P15328, MINT:P15328, STRING:9606.ENSP00000377284, BindingDB:P15328, ChEMBL:CHEMBL2121, DrugBank:DB05595, DrugBank:DB00158, DrugBank:DB00563, DrugBank:DB15413, DrugBank:DB05168, DrugCentral:P15328, TCDB:9.B.92.1.1, GlyConnect:1248, GlyGen:P15328, iPTMnet:P15328, PhosphoSitePlus:P15328, SwissPalm:P15328, BioMuta:FOLR1, DMDM:544337, EPD:P15328, jPOST:P15328, MassIVE:P15328, MaxQB:P15328, PaxDb:P15328, PeptideAtlas:P15328, PRIDE:P15328, ProteomicsDB:53130, ABCD:P15328, Antibodypedia:16919, DNASU:2348, Ensembl:ENST00000312293.9, Ensembl:ENSP00000308137.4, Ensembl:ENSG00000110195.14, Ensembl:ENST00000393676.5, Ensembl:ENSP00000377281.3, Ensembl:ENST00000393679.5, Ensembl:ENSP00000377284.1, Ensembl:ENST00000393681.6, Ensembl:ENSP00000377286.2, Ensembl:ENST00000675784.1, Ensembl:ENSP00000502440.1, GeneID:2348, KEGG:hsa:2348, MANE-Select:ENST00000393676.5, UCSC:uc001orz.3, CTD:2348, DisGeNET:2348, GeneCards:FOLR1, HGNC:3791, HPA:ENSG00000110195, MalaCards:FOLR1, MIM:136430, MIM:613068, neXtProt:NX_P15328, OpenTargets:ENSG00000110195, Orphanet:217382, PharmGKB:PA28207, VEuPathDB:HostDB:ENSG00000110195, eggNOG:KOG3656, GeneTree:ENSGT00950000183144, HOGENOM:CLU_070826_1_1_1, InParanoid:P15328, OMA:HKQCSPW, OrthoDB:1224404at2759, PhylomeDB:P15328, TreeFam:TF328532, PathwayCommons:P15328, Reactome:R-HSA-204005, Reactome:R-HSA-5694530, Reactome:R-HSA-6807878, SignaLink:P15328, SIGNOR:P15328, BioGRID-ORCS:2348, GeneWiki:Folate_receptor_1, GenomeRNAi:2348, Pharos:P15328, PRO:PR:P15328, Proteomes:UP000005640, RNAct:P15328, Bgee:ENSG00000110195, ExpressionAtlas:P15328, Genevisible:P15328, GO:0031362, GO:0016324, GO:0016323, GO:0031526, GO:0009986, GO:0030136, GO:0005789, GO:0033116, GO:0005768, GO:0012507, GO:0070062, GO:0000139, GO:0016020, GO:0005634, GO:0005886, GO:0030133, GO:0005542, GO:0061714, GO:0038023, GO:0061713, GO:0031103, GO:0003253, GO:0007155, GO:0071231, GO:1904447, GO:0046655, GO:0015884, GO:0007342, GO:0001947, GO:0003147, GO:0061626, GO:0006898, GO:0060828, GO:0017015, GO:0070293, GO:0035036, InterPro:IPR004269, InterPro:IPR018143, InterPro:IPR032935, PANTHER:PTHR10517, PANTHER:PTHR10517:SF15, Pfam:PF03024
Sequence maqrmttqlllllvwvavvgeaqtriawartellnvcmnakhhkekpgpedklheqcrpwrknaccstntsqeahkdvsylyrfnwnhcgemapackrhfiqdtclyecspnlgpwiqqvdqswrkervlnvplckedceqwwedcrtsytcksnwhkgwnwtsgfnkcavgaacqpfhfyfptptvlcneiwthsykvsnysrgsgrciqmwfdpaqgnpneevarfyaaamsgagpwaawpfllslalmllwlls