Newcastle disease virus
11176
Newcastle disease
Domestic and wild birds are affected by Newcastle virus, Amazon parrots are can be asymptomatic carriers of the disease (Wiki: Newcastle disease).
Newcastle disease virus (NDV) is a negative-sense single-stranded RNA virus. Transmission occurs by exposure to faecal and other excretions from infected birds, and through contact with contaminated feed, water, equipment and clothing. NDV strains can be categorised as velogenic (highly virulent), mesogenic (intermediate virulence) or lentogenic (nonvirulent). Velogenic strains produce severe nervous and respiratory signs, spread rapidly and cause up to 90% mortality. Mesogenic strains cause coughing, affect egg quality and production and result in up to 10% mortality. Lentogenic strains produce mild signs with negligible mortality. In 1999, promising results were reported using an attenuated strain of the Newcastle virus codenamed MTH-68 in cancer patients. Newcastle disease is a contagious bird disease affecting many domestic and wild avian species. Its effects are most notable in domestic poultry due to their high susceptibility and the potential for severe impacts of an epidemic on the poultry industries. It is endemic to many countries (Wiki: Newcastle disease).
Baboon
Papio cynocephalus
9556
Bank vole
Clethrionomys glareolus
447135
Bear
Ursus americanus
9643
Birds
Passeroidea
175121
Brown Trout
Salmo trutta
8032
Buffalo
Bison bison
9901
Carnivores
Vulpes
9625
Cat
Felis catus
9685
Catfishes
Siluriformes
7995
Cattle
Bos taurus
9913
Chicken
Gallus gallus
9031
Chimpanzee
Pan troglodytes
9598
chinchillas
Chinchillidae
10150
Copper Pheasant
Syrmaticus soemmerringii
9067
Deer
Cervus elaphus
9860
Deer mouse
Peromyscus maniculatus
10042
Dog
Canis familiaris
9615
Ducks
Anas
8835
Ferret
Mustela putorius furo
9669
Fish
Hyperotreti
117565
Gerbil
Gerbillina
10045
Goat
Capra hircus
9925
Gray wolf
Canis lupus
9612
Guinea pig
Cavia porcellus
10141
Hamster
Mesocricetus auratus
10036
Horse
Equus caballus
9796
Human
Homo sapiens
9606
Macaque
Macaca fascicularis
9541
Mongolian Gerbil
Meriones unguiculatus
10047
Monkey
Platyrrhini
9479
Mouse
Mus musculus
10090
None
None
Parrot
Psittacidae
9224
Pig
Sus scrofa
9823
Rabbit
Oryctolagus cuniculus
9986
Rainbow trout
Oncorhynchus mykiss
8022
Rat
Rattus
10114
Raven
Corvus corax
56781
sei whale
Balaenoptera borealis
9768
Sheep
Ovis aries
9940
Squirrel
Spermophilus richardsonii
37591
Tree shrew
Tupaiidae
9393
Trouts, salmons & chars
Salmoninae
504568
Turkey
Meleagris gallopavo
9103
Vole
Microtus ochrogaster
79684
Water buffalo
Bubalus bubalis
391902
Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.10)
Wyeth
VO_0002065
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.11)
Intervet Inc.
VO_0002066
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.43)
Lohmann Animal Health International, Biomune Company
VO_0002068
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease Standard & Variant, Killed Virus Vaccine (USDA: 12G5.42)
Intervet Inc., Biomune Company
VO_0002067
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 12H1.4M)
Merial, Inc.
VO_0002069
Live vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 12H1.67)
Merial, Inc.
VO_0002070
Live vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.40)
Wyeth
VO_0002071
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.43)
Lohmann Animal Health International
VO_0002072
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.62)
Biomune Company
VO_0002074
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12D5.45)
Lohmann Animal Health International, Merial, Inc.
VO_0002060
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12J5.61)
Intervet Inc., Biomune Company
VO_0002073
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.00)
Lohmann Animal Health International, Biomune Company
VO_0002075
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.01)
Intervet Inc., Lohmann Animal Health International, Biomune Company
VO_0002076
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Killed Virus Vaccine (USDA: 12M5.40)
Wyeth
VO_0002078
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.11)
Intervet Inc.
VO_0002077
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.43)
Lohmann Animal Health International
VO_0002081
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.50)
Biomune Company
VO_0002082
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.90)
Wyeth, Lohmann Animal Health International
VO_0002083
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.91)
Wyeth, Lohmann Animal Health International
VO_0002084
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12M5.41)
Lohmann Animal Health International, Merial, Inc.
VO_0002079
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12M5.42)
Lohmann Animal Health International
VO_0002080
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.E0)
Biomune Company
VO_0002085
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.40)
Merial, Inc.
VO_0002086
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.41)
Intervet Inc., Biomune Company
VO_0002087
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.E0)
Biomune Company
VO_0002088
Inactivated or "killed" vaccine
Licensed
USA
HVT-ND
VO_0004632
Recombinant vector vaccine
Research
[Ref3087:Esaki et al., 2013]
Intramuscular injection (i.m.)
A turkey herpesvirus vector Newcastle disease vaccine (HVT/ND) expressing the fusion gene of Newcastle disease virus (NDV) (Esaki et al., 2013).
Intramuscular injection (i.m.)
Recombinant vector construction
A turkey herpesvirus vector Newcastle disease vaccine (HVT/ND) expressing the fusion gene of Newcastle disease virus (NDV) (Esaki et al., 2013).
Chickens were vaccinated by the in ovo route to 18-day-old embryos or by the subcutaneous route to 1-day-old chicks (Esaki et al., 2013).
VO_0003057
Partial protection was observed at 3 weeks of age, when 6 out of 10 (60%) chickens were protected. Full protection was obtained at 4 and 5 weeks of age, when 9 out of 10 (90%) and 10 out of 10 (100%) chickens were protected, respectively. Finally, protection against challenge with virulent Texas GB strain at 19 weeks of age was evaluated in commercial female layer chickens vaccinated at 1 day of age with HVT/ND. All of the vaccinated chickens were protected, while all of the challenge controls succumbed to the challenge (Esaki et al., 2013).
Challenge was conducted using a low-virulence NDV strain (genotype II; pathotype lentogenic) via the respiratory tract each week between 1 and 5 weeks of age, in order to mimic the situation in areas where virulent NDV strains do not normally exist and low-virulence strains cause mild respiratory symptoms leading to economic losses (Esaki et al., 2013).
Marek's Disease-Newcastle Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 16N1.R0)
Intervet Inc., Biomune Company
VO_0002143
Live vaccine
Licensed
USA
Marek's Disease-Newcastle Disease Serotypes 1 & 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 16N1.R2)
Biomune Company
VO_0002145
Live vaccine
Licensed
USA
Marek's Disease-Newcastle Disease Serotypes 1 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 16N1.R1)
Biomune Company
VO_0002144
Live vaccine
Licensed
USA
Marek's Disease-Newcastle Disease Serotypes 2 & 3, Live Virus & Live Marek's Disease Vector Vaccine (USDA: 17H1.R1)
Biomune Company
VO_0002182
Live vaccine
Licensed
USA
Marek's Disease-Newcastle Disease Serotypes 2 & 3, Live Virus & Live Marek's Disease Vector Vaccine (USDA: 17H1.R2)
Intervet Inc.
VO_0002183
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.10)
Wyeth, Lohmann Animal Health International, Merial, Inc.
VO_0001704
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.12)
Intervet Inc.
VO_0001705
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.14)
Intervet Inc.
VO_0001706
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.18)
Wyeth
VO_0001707
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 17A2.10)
Merial, Inc.
VO_0001708
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, C2 Strain, Live VirusVaccine (USDA: 17B1.10)
Intervet Inc.
VO_0001709
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.0A)
Lohmann Animal Health International
VO_0001710
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.10)
Wyeth, Lohmann Animal Health International, Biomune Company
VO_0001711
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.11)
Merial, Inc.
VO_0001712
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.15)
Intervet Inc.
VO_0001713
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.16)
Intervet Inc.
VO_0001714
Live vaccine
Licensed
USA
Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.17)
Intervet Inc.
VO_0001715
Live vaccine
Licensed
USA
Newcastle Disease Killed Virus Vaccine (USDA: 1705.10)
Wyeth, Intervet Inc., Biomune Company
VO_0001716
Inactivated or "killed" vaccine
Licensed
USA
Newcastle Disease Killed Virus Vaccine (USDA: 1705.11)
Wyeth, Lohmann Animal Health International
VO_0001717
Inactivated or "killed" vaccine
Licensed
USA
Newcastle Disease Killed Virus Vaccine (USDA: 1705.13)
Wyeth
VO_0001718
Inactivated or "killed" vaccine
Licensed
USA
Newcastle Disease Killed Virus Vaccine (USDA: 1705.15)
Lohmann Animal Health International
VO_0001719
Inactivated or "killed" vaccine
Licensed
USA
Newcastle Disease VG/GA Strain, Live Virus Vaccine (USDA: 1701.10)
Merial, Inc.
VO_0001720
Live vaccine
Licensed
USA
Newcastle Disease VG/GA Strain, Live Virus Vaccine (USDA: 17A2.V1)
Merial, Inc.
VO_0001721
Live vaccine
Licensed
USA
Newcastle disease virus DNA vaccine pCAGF encoding the F protein
VO_0004324
DNA vaccine
Research
Pcaggs [Ref2160:Sakaguchi et al., 1996]
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
DNA vaccine construction
Vector Pcaggs expressed the Newcastle disease virus Fprotein (NDV-F) (Sakaguchi et al., 1996).
VO_0000286
At 9 weeks post-injection, chickens were challenged with the velogenic NDV Sato strain. The chickens that had the antibody against NDV-F from immunization were protected from lethal NDV challenge. The DNA vaccine conferred efficient protection against the disease (Sakaguchi et al., 1996).
Newcastle Disease Virus HN Glycoprotein Subunit Vaccine
VO_0011552
Subunit vaccine
Research
Baculovirus [Ref1215:Lee et al., 2008].
Intramuscular injection (i.m.)
Montanide Incomplete Seppic Adjuvant (Lee et al., 2008).
Intramuscular injection (i.m.)
Hemagglutinin-neuraminidase (HN) glycoprotein (Lee et al., 2008).
Recombinant protein preparation
For vaccination, chickens were inoculated intramuscularly with the Seppic-adjuvanted antigen (Lee et al., 2008).
A single dose of rNDHN(V) had a protective effect against mortality (p <0.01) in chickens (Lee et al., 2008).
Each group of vaccinated and unvaccinated chickens was challenged with the vvNDV Kr-005/00 strain through an intraocular inoculation with an 10^5.5 EID50 per bird. vvNDV Kr-005/00 was the representative strain of genotype VII, which is the dominant epizootic genotype in Korea. The chickens were kept under observation for 14 days after infection (Lee et al., 2008).
Newcastle disease virus vaccine by Dow AgroSciences
Dow AgroSciences
VO_0011474
Live, attenuated vaccine
Licensed
Intramuscular injection (i.m.)
HN recombinant produced in plant cell lines (registered but not on market)(Meeusen et al., 2007)
Intramuscular injection (i.m.)
Newcastle Disease-Bronchitis Mass & Ark Types, Killed Virus Vaccine-Salmonella Enteritidis Bacterin (USDA: 48D7.10)
Lohmann Animal Health International
VO_0002282
Inactivated or "killed" vaccine
Licensed
USA
Newcastle Disease-Bronchitis Mass & Ark Types, Killed Virus Vaccine-Salmonella Enteritidis Bacterin (USDA: 48D7.11)
Lohmann Animal Health International
VO_0002283
Inactivated or "killed" vaccine
Licensed
USA
Newcastle Disease-Fowl Pox Live Fowl Pox Vector Vaccine (USDA: 17C1.R0)
Merial, Inc., Biomune Company
VO_0002181
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Conn Type, Live Virus Vaccine (USDA: 1761.13)
Merial, Inc.
VO_0002150
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Conn Type, Live Virus Vaccine (USDA: 1761.1A)
Intervet Inc.
VO_0002156
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Conn Type, Live Virus Vaccine (USDA: 1762.13)
Merial, Inc.
VO_0002158
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 1791.1X)
Intervet Inc.
VO_0002176
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 17A1.1M)
Wyeth, Merial, Inc.
VO_0002177
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 17A1.1N)
Intervet Inc.
VO_0002178
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 17A2.1M)
Merial, Inc.
VO_0002179
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1761.14)
Wyeth, Intervet Inc., Merial, Inc.
VO_0002151
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1761.15)
Merial, Inc.
VO_0002152
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1761.17)
Lohmann Animal Health International
VO_0002153
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1762.1H)
Merial, Inc.
VO_0002159
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1791.14)
Intervet Inc.
VO_0002173
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1791.15)
Intervet Inc.
VO_0002174
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.11)
Wyeth, Merial, Inc.
VO_0002148
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.12)
Intervet Inc., Lohmann Animal Health International, Merial, Inc.
VO_0002149
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.18)
Wyeth, Intervet Inc.
VO_0002154
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1761.19)
Intervet Inc.
VO_0002155
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1762.11)
Merial, Inc.
VO_0002157
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1791.19)
Intervet Inc.
VO_0002175
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, B1 Strain, Mass Type, Live Virus Vaccine (USDA: 1791.1X)
Intervet Inc.
VO_0004207
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, C2 Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1XC1.10)
Intervet Inc.
VO_0002204
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, C2 Strain, Mass Type, Live Virus Vaccine (USDA: 1XB1.10)
Intervet Inc.
VO_0002203
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, LaSota Strain, Mass & Conn Types Vaccine (USDA: 17B1.17)
Intervet Inc.
VO_0002180
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, LaSota Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1771.14)
Intervet Inc., Merial, Inc.
VO_0002162
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, LaSota Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 1771.17)
Merial, Inc.
VO_0002163
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.11)
Wyeth, Lohmann Animal Health International, Merial, Inc.
VO_0002160
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.12)
Wyeth, Merial, Inc.
VO_0002161
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.18)
Intervet Inc., Lohmann Animal Health International
VO_0002164
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.19)
Intervet Inc.
VO_0002165
Live vaccine
Licensed
USA
Newcastle-Bronchitis B1 Type, LaSota Strain, Mass Type, Live Virus Vaccine (USDA: 1771.1A)
Intervet Inc.
VO_0002166
Live vaccine
Licensed
USA
Newcastle-Bronchitis Mass & Ark Types, Killed Virus Vaccine (USDA: 1785.10)
Lohmann Animal Health International
VO_0002170
Licensed
USA
Newcastle-Bronchitis Mass & Ark Types, Killed Virus Vaccine (USDA: 1785.12)
Merial, Inc.
VO_0002172
Inactivated or "killed" vaccine
Licensed
USA
Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1775.10)
Wyeth, Biomune Company
VO_0002167
Inactivated or "killed" vaccine
Licensed
USA
Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1775.11)
Intervet Inc.
VO_0002168
Inactivated or "killed" vaccine
Licensed
USA
Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1776.10)
Wyeth
VO_0002169
Inactivated or "killed" vaccine
Licensed
USA
Newcastle-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 1785.11)
Lohmann Animal Health International
VO_0002171
Inactivated or "killed" vaccine
Licensed
USA
Newcastle-Bronchitis Mass Type, Killed Virus Vaccine-Mycoplasma Gallisepticum Bacterin (USDA: 48B5.10)
Lohmann Animal Health International
VO_0002275
Inactivated or "killed" vaccine
Licensed
USA
Newcastle-Bronchitis Mass Type, Killed Virus Vaccine-Mycoplasma Gallisepticum Bacterin (USDA: 48B6.10)
Wyeth, Intervet Inc.
VO_0002276
Inactivated or "killed" vaccine
Licensed
USA
Newcastle-Bronchitis Mass Type, Killed Virus Vaccine-Salmonella Enteritidis Bacterin (USDA: 48D6.10)
Wyeth, Intervet Inc., Biomune Company
VO_0002281
Inactivated or "killed" vaccine
Licensed
USA
Newcastle-Bronchitis VG/GA Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 17V1.10)
Merial, Inc.
VO_0002185
Live vaccine
Licensed
USA
Newcastle-Bronchitis VG/GA Strain, Mass & Conn Types, Live Virus Vaccine (USDA: 17V1.11)
Merial, Inc.
VO_0002186
Live vaccine
Licensed
USA
Newcastle-Paramyxovirus Type 3, Killed Virus Vaccine (USDA: 17P5.10)
Lohmann Animal Health International
VO_0002184
Inactivated or "killed" vaccine
Licensed
USA
rAPMV3-F (newcastle disease)
VO_0004684
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
Recombinant virus, rAPMV3-F generated expressinv the NDV fusion protein (Kumar et al., 2011).
Intramuscular injection (i.m.)
Recombinant protein preparation
Recombinant viruses, rAPMV3-F and rAPMV3-HN, were generated expressing the NDV fusion (F) and hemagglutinin-neuraminidase (HN) proteins (Kumar et al., 2011).
Recombinant vector construction
Recombinant viruses, rAPMV3-F and rAPMV3-HN, were generated expressing the NDV fusion (F) and hemagglutinin-neuraminidase (HN) proteins (Kumar et al., 2011).
2-week-old chickens were immunized by the oculonasal route in order to evaluate the contribution of each protein to the induction of NDV-specific neutralizing antibodies and protective immunity (Kumar et al., 2011).
VO_0003057
With oculonasal or intramuscular challenge, all three recombinant viruses (rAPMV3, rAPMV3-F, and rAPMV3-HN) were protective, while all unvaccinated birds succumbed to death. However, with intravenous challenge, birds immunized with rAPMV3 were not protected, whereas birds immunized with rAPMV3-F alone or in combination with rAPMV3-HN were completely protected, and birds immunized with rAPMV3-HN alone were partially protected. These results indicate that the NDV F and HN proteins are independent neutralization and protective antigens, but the contribution by F is greater (Kumar et al., 2011).
The immunized birds were challenged 21 days after vaccination with virulent NDV via the oculonasal, intramuscular, or intravenous route (Kumar et al., 2011).
rFPV-NDV-H/F
VO_0004751
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
(Boursnell et al., 1990)
Intramuscular injection (i.m.)
Vectormune FP-ND
Vectormune FP-ND
Biomune
VO_0001016
Recombinant vector vaccine
Licensed
Intramuscular injection (i.m.)
Fowlpox virus vectored
Intramuscular injection (i.m.)
F fusion protein
Newcastle disease virus B1
VO_0011208
912271
11545723
NDVgp4
AF309418
NP_071469
3MAW
139270
4497
6278
+
fusion protein
8.34
55332.07
553
>NC_002617.1:4497-6278 Newcastle disease virus B1, complete genome
CACGGGTAGAAGACTCTGGATCCCGGTTGGCGCCCTCCAGGTGCAGGATGGGCTCCAGACCTTTTACCAA
GAACCCAGCACCTATGATGCTGACTATCCGGGTCGCGCTGGTATTGAGTTGCATCTGTCCGGCAAACTCC
ATTGATGGCAGGCCTTTTGCAGCTGCAGGAATTGTGGTTACAGGAGACAAAGCAGTCAACATATACACCT
CATCCCAGACAGGATCAATCATAGTTAAGCTCCTCCCGAATCTGCCCAAGGATAAGGAGGCATGTGCGAA
AGCCCCCTTGGATGCATACAACAGGACATTGACCACTTTGCTCACCCCCCTTGGTGACTCTATCCGTAGG
ATACAAGAGTCTGTGACTACATCTGGAGGGGGGAGACAGGGGCGCCTTATAGGCGCCATTATTGGCGGTG
TGGCTCTTGGGGTTGCAACTGCCGCACAAATAACAGCGGCCGCAGCTCTGATACAAGCCAAACAAAATGC
TGCCAACATCCTCCGACTTAAAGAGAGCATTGCCGCAACCAATGAGGCTGTGCATGAGGTCACTGACGGA
TTATCCCAACTAGCAGTGGCAGTTGGGAAGATGCAGCAGTTTGTTAATGACCAATTTAATAAAACAGCTC
AGGAATTAGACTGCATAAAAATTGCACAGCAAGTTGGTGTAGAGCTCAACCTGTACCTAACCGAATTGAC
TACAGTATTCGGACCACAAATCACTTCACCTGCCTTAAACAAGCTGACTATTCAGGCACTTTACAATCTA
GCTGGTGGGAATATGGATTACTTATTGACTAAGTTAGGTATAGGGAACAATCAACTCAGCTCATTAATCG
GTAGCGGCTTAATCACCGGTAACCCTATTCTATACGACTCACAGACTCAACTCTTGGGTATACAGGTAAC
TCTACCTTCAGTCGGGAACCTAAATAATATGCGTGCCACCTACTTGGAAACCTTATCCGTAAGCACAACC
AGGGGATTTGCCTCGGCACTTGTCCCAAAAGTGGTGACACAGGTCGGTTCTGTGATAGAAGAACTTGACA
CCTCATACTGTATAGAAACTGACTTAGATTTATATTGTACAAGAATAGTAACGTTCCCTATGTCCCCTGG
TATTTACTCCTGCTTGAGCGGCAATACATCGGCCTGTATGTACTCAAAGACCGAAGGCGCACTTACTACA
CCATATATGACTATCAAAGGCTCAGTCATCGCTAACTGCAAGATGACAACATGTAGATGTGTAAACCCCC
CGGGTATCATATCGCAAAACTATGGAGAAGCCGTGTCTCTAATAGATAAACAATCATGCAATGTTTTATC
CTTAGGCGGGATAACTTTAAGGCTCAGTGGGGAATTCGATGTAACTTATCAGAAGAATATCTCAATACAA
GATTCTCAAGTAATAATAACAGGCAATCTTGATATCTCAACTGAGCTTGGGAATGTCAACAACTCGATCA
GTAATGCTTTGAATAAGTTAGAGGAAAGCAACAGAAAACTAGACAAAGTCAATGTCAAACTGACCAGCAC
ATCTGCTCTCATTACCTATATCGTTTTGACTATCATATCTCTTGTTTTTGGTATACTTAGCCTGATTCTA
GCATGCTACCTAATGTACAAGCAAAAGGCGCAACAAAAGACCTTATTATGGCTTGGGAATAATACCCTAG
ATCAGATGAGAGCCACTACAAAAATGTGAACACAGATGAGGAACGAAGGTTTCCCTAATAGTAATTTGTG
TGAAAGTTCTGGTAGTCTGTCAGTTCGGAGAG
>NP_071469.1 fusion protein [Newcastle disease virus B1]
MGSRPFTKNPAPMMLTIRVALVLSCICPANSIDGRPFAAAGIVVTGDKAVNIYTSSQTGSIIVKLLPNLP
KDKEACAKAPLDAYNRTLTTLLTPLGDSIRRIQESVTTSGGGRQGRLIGAIIGGVALGVATAAQITAAAA
LIQAKQNAANILRLKESIAATNEAVHEVTDGLSQLAVAVGKMQQFVNDQFNKTAQELDCIKIAQQVGVEL
NLYLTELTTVFGPQITSPALNKLTIQALYNLAGGNMDYLLTKLGIGNNQLSSLIGSGLITGNPILYDSQT
QLLGIQVTLPSVGNLNNMRATYLETLSVSTTRGFASALVPKVVTQVGSVIEELDTSYCIETDLDLYCTRI
VTFPMSPGIYSCLSGNTSACMYSKTEGALTTPYMTIKGSVIANCKMTTCRCVNPPGIISQNYGEAVSLID
KQSCNVLSLGGITLRLSGEFDVTYQKNISIQDSQVIITGNLDISTELGNVNNSISNALNKLEESNRKLDK
VNVKLTSTSALITYIVLTIISLVFGILSLILACYLMYKQKAQQKTLLWLGNNTLDQMRATTKM
Protective antigen
A recombinant fowlpox virus expressing the fusion protein of Newcastle disease virus strain F48E8 protected chickens against virulent NDV challenge. The protective rate was 96.7% [Ref1317:Wu et al., 2000].
HN hemagglutinin-neuraminidase
Newcastle disease virus B1
VO_0011209
912270
11545724
NDVgp5
AF309418
NP_071470
1USR
139270
6320
8311
+
hemagglutinin-neuraminidase
7.24
59257.8
577
>NC_002617.1:6320-8311 Newcastle disease virus B1, complete genome
TACGGGTAGAACGGTAAGAGAGGCCGCCCCTCAATTGCGAGCCAGACTTCACAACCTCCGTTCTACCGCT
TCACCGACAACAGTCCTCAATCATGGACCGCGCCGTTAGCCAAGTTGCGTTAGAGAATGATGAAAGAGAG
GCAAAAAATACATGGCGCTTGATATTCCGGATTGCAATCTTATTCTTAACAGTAGTGACCTTGGCTATAT
CTGTAGCCTCCCTTTTATATAGCATGGGGGCTAGCACACCTAGCGATCTTGTAGGCATACCGACTAGGAT
TTCCAGGGCAGAAGAAAAGATTACATCTACACTTGGTTCCAATCAAGATGTAGTAGATAGGATATATAAG
CAAGTGGCCCTTGAGTCTCCATTGGCATTGTTAAATACTGAGACCACAATTATGAACGCAATAACATCTC
TCTCTTATCAGATTAATGGAGCTGCAAACAACAGCGGGTGGGGGGCACCTATTCATGACCCAGATTATAT
AGGGGGGATAGGCAAAGAACTCATTGTAGATGATGCTAGTGATGTCACATCATTCTATCCCTCTGCATTT
CAAGAACATCTGAATTTTATCCCGGCGCCTACTACAGGATCAGGTTGCACTCGAATACCCTCATTTGACA
TGAGTGCTACCCATTACTGCTACACCCATAATGTAATATTGTCTGGATGCAGAGATCACTCACACTCATA
TCAGTATTTAGCACTTGGTGTGCTCCGGACATCTGCAACAGGGAGGGTATTCTTTTCTACTCTGCGTTCC
ATCAACCTGGACGACACCCAAAATCGGAAGTCTTGCAGTGTGAGTGCAACTCCCCTGGGTTGTGATATGC
TGTGCTCGAAAGCCACGGAGACAGAGGAAGAAGATTATAACTCAGCTGTCCCTACGCGGATGGTACATGG
GAGGTTAGGGTTCGACGGCCAATATCACGAAAAGGACCTAGATGTCACAACATTATTCGGGGACTGGGTG
GCCAACTACCCAGGAGTAGGGGGTGGATCTTTTATTGACAGCCGCGTATGGTTCTCAGTCTACGGAGGGT
TAAAACCCAATTCACCCAGTGACACTGTACAGGAAGGGAAATATGTGATATACAAGCGATACAATGACAC
ATGCCCAGATGAGCAAGACTACCAGATTCGAATGGCCAAGTCTTCGTATAAGCCTGGACGGTTTGGTGGG
AAACGCATACAGCAGGCTATCTTATCTATCAAAGTGTCAACATCCTTAGGCGAAGACCCGGTACTGACTG
TACCGCCCAACACAGTCACACTCATGGGGGCCGAAGGCAGAATTCTCACAGTAGGGACATCCCATTTCTT
GTATCAGCGAGGGTCATCATACTTCTCTCCCGCGTTATTATATCCTATGACAGTCAGCAACAAAACAGCC
ACTCTTCATAGTCCTTATACATTCAATGCCTTCACTCGGCCAGGTAGTATCCCTTGCCAGGCTTCAGCAA
GATGCCCCAACTCGTGTGTTACTGGAGTCTATACAGATCCATATCCCCTAATCTTCTATAGAAACCACAC
CTTGCGAGGGGTATTCGGGACAATGCTTGATGGTGAACAAGCAAGACTTAACCCTGCGTCTGCAGTATTC
GATAGCACATCCCGCAGTCGCATAACTCGAGTGAGTTCAAGCAGCATCAAAGCAGCATACACAACATCAA
CTTGTTTTAAAGTGGTCAAGACCAATAAGACCTATTGTCTCAGCATTGCTGAAATATCTAATACTCTCTT
CGGAGAATTCAGAATCGTCCCGTTACTAGTTGAGATCCTCAAAGATGACGGGGTTAGAGAAGCCAGGTCT
GGCTAGTTGAGTCAACTATGAAAGAGTTGGAAAGATGGCATTGTATCACCTATCTTCTGCGACATCAAGA
ATCAAACCGAATGCCGGCGCGTGCTCGAATTCCATGTCGCCAGTTGACCACAATCAGCCAGTGCTCATGC
GATCAGATTAAGCCTTGTCAATAGTCTCTTGA
>NP_071470.1 hemagglutinin-neuraminidase [Newcastle disease virus B1]
MDRAVSQVALENDEREAKNTWRLIFRIAILFLTVVTLAISVASLLYSMGASTPSDLVGIPTRISRAEEKI
TSTLGSNQDVVDRIYKQVALESPLALLNTETTIMNAITSLSYQINGAANNSGWGAPIHDPDYIGGIGKEL
IVDDASDVTSFYPSAFQEHLNFIPAPTTGSGCTRIPSFDMSATHYCYTHNVILSGCRDHSHSYQYLALGV
LRTSATGRVFFSTLRSINLDDTQNRKSCSVSATPLGCDMLCSKATETEEEDYNSAVPTRMVHGRLGFDGQ
YHEKDLDVTTLFGDWVANYPGVGGGSFIDSRVWFSVYGGLKPNSPSDTVQEGKYVIYKRYNDTCPDEQDY
QIRMAKSSYKPGRFGGKRIQQAILSIKVSTSLGEDPVLTVPPNTVTLMGAEGRILTVGTSHFLYQRGSSY
FSPALLYPMTVSNKTATLHSPYTFNAFTRPGSIPCQASARCPNSCVTGVYTDPYPLIFYRNHTLRGVFGT
MLDGEQARLNPASAVFDSTSRSRITRVSSSSIKAAYTTSTCFKVVKTNKTYCLSIAEISNTLFGEFRIVP
LLVEILKDDGVREARSG
Protective antigen
Recombinant baculoviruses containing the fusion (F) and hemagglutinin-neuraminidase (HN) glycoprotein gene of the viscerotropic velogenic (vv) Newcastle disease virus (NDV) isolate, Kr-005/00, and a lentogenic La Sota strain of the NDV were constructed. A single dose of rNDHN(V) had a protective effect against mortality (p <0.01) in chickens [Ref1215:Lee et al., 2008].
Boursnell et al., 1990
journal
Boursnell ME, Green PF, Samson AC, Campbell JI, Deuter A, Peters RW, Millar NS, Emmerson PT, Binns MM
A recombinant fowlpox virus expressing the hemagglutinin-neuraminidase gene of Newcastle disease virus (NDV) protects chickens against challenge by NDV
1990
178
1
297-300
Virology
Esaki et al., 2013
journal
Esaki M, Godoy A, Rosenberger JK, Rosenberger SC, Gardin Y, Yasuda A, Dorsey KM
Protection and antibody response caused by turkey herpesvirus vector Newcastle disease vaccine
2013
57
4
750-755
Avian diseases
Kumar et al., 2011
journal
Kumar S, Nayak B, Collins PL, Samal SK
Evaluation of the Newcastle disease virus F and HN proteins in protective immunity by using a recombinant avian paramyxovirus type 3 vector in chickens
2011
85
13
6521-6534
Journal of virology
Lee et al., 2008
journal
Lee YJ, Sung HW, Choi JG, Lee EK, Yoon H, Kim JH, Song CS
Protection of chickens from Newcastle disease with a recombinant baculovirus subunit vaccine expressing the fusion and hemagglutininneuraminidase proteins
2008
9
3
301-308
Journal of veterinary science
Meeusen et al., 2007
journal
Meeusen EN, Walker J, Peters A, Pastoret PP, Jungersen G
Current status of veterinary vaccines
2007
20
3
489-510
Clinical microbiology reviews
Sakaguchi et al., 1996
journal
Sakaguchi M, Nakamura H, Sonoda K, Hamada F, Hirai K
Protection of chickens from Newcastle disease by vaccination with a linear plasmid DNA expressing the F protein of Newcastle disease virus
1996
14
8
747-752
Vaccine
Wiki: Newcastle disease
website
Newcastle disease
http://en.wikipedia.org/wiki/Newcastle_disease_virus
Wu et al., 2000
journal
Wu YT, Peng DX, Liu XF, Liu WZ, Zhang RK
[A recombinant fowlpox virus expressing the fusion protein of Newcastle disease virus strain F48E8 and its protective efficacy]
2000
16
5
591-594
Sheng wu gong cheng xue bao = Chinese journal of biotechnology