Human Immunodeficiency Virus
12721
The 3 major routes of HIV transmission are sexual intercourse, contaminated needles, and transmission from an infected mother to her baby at birth, or through breast milk. HIV primarily infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. This decreases CD4+ T cells through direct viral killing of infected cells, increased rates of apoptosis in infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity (CMI) is lost, and the body becomes progressively more susceptible to opportunistic infections (Chan et al., 1997).
Acquired Immunodeficiency Syndrome (AIDS)
HIV can infect a variety of immune cells such as CD4+ T cells, macrophages, and microglial cells. HIV-1 entry to macrophages and T cells is mediated through interaction of the virion envelope glycoproteins (gp120) with the CD4 molecule on target cells and also with chemokine coreceptors. Macrophages play a key role in several critical aspects of HIV infection. They appear to be the first cells infected by HIV and perhaps the source of HIV production when CD4+ cells become depleted in the patient. T-tropic isolates, or syncitia-inducing (SI) strains replicate in primary CD4+ T cells as well as in macrophages. Dual-tropic HIV-1 strains are thought to be transitional strains of the HIV-1 virus. HIV can also infect a subtype of myeloid dendritic cells, which probably constitute a reservoir that maintains infection when CD4+ T cell numbers have declined to extremely low levels (Chan et al., 1997)(Coakley et al., 2005)(Deng et al., 1996)(Knight et al., 1990).
AIDS has killed more than 25 million people since it was first recognized in 1981. Globally, ~40 million people currently live with HIV. Sub-Saharan Africa remains by far the worst-affected region. More than 64% of all people living with HIV are in sub-Saharan Africa, as are more than three quarters of all women living with HIV. Two-thirds of HIV/AIDS infections in Asia occur in India, with an estimated 6 million infections, surpassing South Africa's 5.5 million infections, making India the country with the highest number of HIV infections in the world (Palella et al., 1998).
Human immunodeficiency virus (HIV) is the retrovirus that causes acquired immunodeficiency syndrome (AIDS). Within bodily fluids, HIV is present as both free virus particles and as virus within infected immune cells. So far, AIDS has killed more than 25 million people since it was first recognized in 1981, making it one of the most destructive pandemics in recorded history. Antiretroviral treatment reduces both the mortality and the morbidity of HIV infection, but routine access to antiretroviral medication is not available in all countries. Most HIV-infected individuals develop AIDS and die; however, about 10% remains healthy for many years, with no noticeable symptoms. Treatment with anti-retrovirals increases the life expectancy of people infected with HIV (Palella et al., 1998) (Buchbinder et al., 1994).
Baboon
Papio cynocephalus
9556
Bank vole
Clethrionomys glareolus
447135
Bear
Ursus americanus
9643
Birds
Passeroidea
175121
Brown Trout
Salmo trutta
8032
Buffalo
Bison bison
9901
Carnivores
Vulpes
9625
Cat
Felis catus
9685
Catfishes
Siluriformes
7995
Cattle
Bos taurus
9913
Chicken
Gallus gallus
9031
Chimpanzee
Pan troglodytes
9598
chinchillas
Chinchillidae
10150
Copper Pheasant
Syrmaticus soemmerringii
9067
Deer
Cervus elaphus
9860
Deer mouse
Peromyscus maniculatus
10042
Dog
Canis familiaris
9615
Ducks
Anas
8835
Ferret
Mustela putorius furo
9669
Fish
Hyperotreti
117565
Gerbil
Gerbillina
10045
Goat
Capra hircus
9925
Gray wolf
Canis lupus
9612
Guinea pig
Cavia porcellus
10141
Hamster
Mesocricetus auratus
10036
Horse
Equus caballus
9796
Human
Homo sapiens
9606
Macaque
Macaca fascicularis
9541
Mongolian Gerbil
Meriones unguiculatus
10047
Monkey
Platyrrhini
9479
Mouse
Mus musculus
10090
None
None
Parrot
Psittacidae
9224
Pig
Sus scrofa
9823
Rabbit
Oryctolagus cuniculus
9986
Rainbow trout
Oncorhynchus mykiss
8022
Rat
Rattus
10114
Raven
Corvus corax
56781
sei whale
Balaenoptera borealis
9768
Sheep
Ovis aries
9940
Squirrel
Spermophilus richardsonii
37591
Tree shrew
Tupaiidae
9393
Trouts, salmons & chars
Salmoninae
504568
Turkey
Meleagris gallopavo
9103
Vole
Microtus ochrogaster
79684
Water buffalo
Bubalus bubalis
391902
Adenoviral vector Ad5 expressing SIV gag protein
VO_0000788
Recombinant vector vaccine
Research
Adenoviral vector (Ad5)
Intramuscular injection (i.m.)
The adenoviral vector was based on a serotype 5 adenovirus that is incompetent to replicate with deletion of the E1 and E3 viral genes, and was propagated subsequently in E1-expressing 293 cells. Recombinant adenovirus expressing the codon-optimized SIV gag gene was then prepared. The recombinant adenovirus (Ad5-SIVgag) was grown in large quantities by multiple rounds of amplification in 293 cells. The virus was purified by caesium chloride gradient centrifugation (Shiver et al., 2002).
Intramuscular injection (i.m.)
SIVmac239 gag protein (Shiver et al., 2002)
Recombinant vector construction
In general, all of the monkeys developed p11CM-specific cellular immune responses after the initial immunization series. The p11CM (residues 181–189) is an immunodominant SIV gag epitope that is presented by the Mamu-A*01 MHC protein and is capable of binding T-cell receptors in the model monkeys. Administration of the third dose of the Ad5 vector resulted in an additional increase of p11CM-specific CD8+ T cells at the time of virus challenge. After the booster inoculation, these animals exhibited peak levels of p11CM-specific CD8+ T cells (Shiver et al., 2002).
rhesus monkey (Macaca mulatta)
In this study, 21 rhesus monkeys were divided into 6 groups, including an unimmunized control cohort. Each of the test vectors expressed the identical SIVmac239 gag gene that had been codon optimized for expression in mammalian cells. In the first study, the two viral vector vaccines were administered, followed by a booster dose; preparations of DNA plasmid vector vaccine were delivered thrice, followed by a booster (Shiver et al., 2002).
Each of the animals in both control groups exhibited acute CD4+ T-cell lymphopenia and peak viral loads of viral RNA copies at about 3 weeks after challenge. With the exception of one animal, all of the control monkeys experienced dramatic loss of CD4+ T cells. During the acute phase of the infection, most monkeys immunized with either the DNA or MVA vectors exhibit an acute CD4+ T-cell lymphopenia. By about 70 d after challenge, many of the immunized monkeys exhibit some evidence of a positive immunization benefit, as manifested by control of viremia and recovery of CD4+ T-cell counts. However, the animals immunized with Ad5 vector exhibited the most pronounced attenuation of the infection with a pathogenic HIV–SIV hybrid virus (SHIV) (Shiver et al., 2002).
At 12 weeks after the final immunization, all monkeys were challenged i.v. with the pathogenic HIV–SIV hybrid virus (SHIV) 89.6P16. The challenge of the control and immunized animals within the context of each of the two independent studies occurred concurrently (Shiver et al., 2002).
ALVAC-HIV-2
VO_0004727
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
A live non-pathogenic HIV-2 following priming with ALVAC HIV-2 (recombinant canarypox virus expressing HIV-2 env, gag and pol) (Walther-Jallow et al., 2001).
Intramuscular injection (i.m.)
Recombinant vector construction
Live non-pathogenic HIV-2 following priming with ALVAC HIV-2 (recombinant canarypox virus expressing HIV-2 env, gag and pol) (Walther-Jallow et al., 2001).
Recombinant vector construction
Live non-pathogenic HIV-2 following priming with ALVAC HIV-2 (recombinant canarypox virus expressing HIV-2 env, gag and pol) (Walther-Jallow et al., 2001).
Five monkeys were immunized either three times with ALVAC HIV-2 alone or twice with ALVAC HIV-2 and once with purified native HIV-2 gp125 (Walther-Jallow et al., 2001).
VO_0003057
After challenge with SIVsm, three of five monkeys were completely protected against SIVsm infection. Vaccination with an ALVAC HIV-2 vaccine followed by exposure to live HIV-2 could induce cross-protection against mucosal infection with SIVsm and seemed to be more efficient than immunization with a live HIV-2 vaccine only (Walther-Jallow et al., 2001).
The monkeys were then challenged with HIV-2 given intravenously and finally with pathogenic SIVsm given intrarectally (Walther-Jallow et al., 2001).
ALVAC-HIV-2- env/gag/pol
VO_0004737
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
A live non-pathogenic HIV-2 following priming with ALVAC HIV-2 (recombinant canarypox virus expressing HIV-2 env, gag and pol) (Walther-Jallow et al., 2001).
Intramuscular injection (i.m.)
Recombinant vector construction
Live attenuated human immunodeficiency virus type 2 (HIV-2) vaccine alone versus boosting with live non-pathogenic HIV-2 following priming with ALVAC HIV-2 (recombinant canarypox virus expressing HIV-2 env, gag and pol) (Walther-Jallow et al., 2001).
Recombinant vector construction
Live attenuated human immunodeficiency virus type 2 (HIV-2) vaccine alone versus boosting with live non-pathogenic HIV-2 following priming with ALVAC HIV-2 (recombinant canarypox virus expressing HIV-2 env, gag and pol) (Walther-Jallow et al., 2001).
Six monkeys were first inoculated intravenously with live HIV-2(SBL-6669) (Walther-Jallow et al., 2001).
VO_0003057
Vaccination with an ALVAC HIV-2 vaccine followed by exposure to live HIV-2 could induce cross-protection against mucosal infection with SIVsm and seemed to be more efficient than immunization with a live HIV-2 vaccine only (Walther-Jallow et al., 2001).
7 to 10 months after vaccination, the monkeys were challenged intrarectally with 10 MID(50) of cell-free simian immunodeficiency virus (SIV) strain SIVsm (Walther-Jallow et al., 2001).
ALVAC-SIV/gp120
VO_0004638
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
CVB4/p24(73(3))
VO_0004719
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
A live coxsackievirus B4 recombinant, CVB4/p24(73(3)), that expresses seventy-three amino acids of the gag p24 sequence (HXB2) (Gu et al., 2010).
Intramuscular injection (i.m.)
Immunization was by intraperitoneal (IP) injection or by oral gavage. Mice were immunized with either CVB4/p24(733) or the parental CVB4. PBS-treated mice served as controls (Gu et al., 2010).
VO_0003057
Results showed that oral immunization with CVB4/p24(73(3)) induced gag p24-specific immune responses in vector-immune mice (Gu et al., 2010).
Mice immunized with the avirulent CVB4 variant are protected when subsequently challenged with a virulent variant (Gu et al., 2010).
DNA and poxvirus priming-boosting SHIV vaccine
VO_0000825
DNA vaccine
pV1R plasmid and recombinant fowlpox virus
An HIV vaccine should elicit a cytotoxic T lymphocyte (CTL) response, but the characteristics of effective vaccine-induced CTL response remain unclear. The SHIV/rhesus monkey model has been used to in the course of assessing the relative immunogenicity of vaccine regimens that include a cytokine-augmented plasmid DNA prime and a boost with DNA or recombinant pox vectors. This study indicates that the steady-state memory, rather than the peak effector vaccine-elicited CTL responses, may be the critical immune correlate of protection for a CTL-based HIV vaccine (Santra et al., 2004).
IL-2/Ig (Santra et al., 2004)
The recombinant vaccinia viruses (rVac) expressing SHIV89.6P env and SIVmac239 gag were constructed by inserting these genes in the HindIII M region of TBC-Wy, Therion strain of vaccinia. rFPV viruses expressing these same genes were constructed by inserting the genes in the BamJHI region of POXVAC-TC (Schering-Plough) strain of FPV (Santra et al., 2004).
SHIV89.6P env and SIVmac239 gag (Santra et al., 2004)
DNA vaccine construction
DNA vaccine construction
Recombinant vaccinia virus, MVA, and fowlpox were comparable in their immunogenicity. Magnitude of peak vaccine-elicited CTL responses in pox virus-boosted monkeys is substantially greater than that seen in monkeys immunized with plasmid DNA alone, but magnitudes of recombinant pox boosted CTL responses decayed rapidly and were comparable to those of the DNA-alone vaccinated monkeys by the time of viral challenge. Clinical protection seen in all groups of experimentally vaccinated monkeys is similar, indicating that steady-state memory, rather than peak effector vaccine-elicited T lymphocyte responses, may be the critical immune correlate of protection for a CTL-based HIV vaccine (Santra et al., 2004).
rhesus monkey (Macaca mulatta)
Nonrecombinant wildtype vaccinia virus was designated VV-WT, wild-type fowlpox virus was designated FPV-WT, and wild-type MVA was designated MVA-WT. These wild-type viruses were used as control vector immunogens (Santra et al., 2004). One group of monkeys were vaccinated by separate i.m. injections of HIV-1. Half the dose was delivered to each quadriceps muscle. Seven of the 28 monkeys were vaccinated by both i.d. and i.m. injections of rFPV expressing HIV-1 89.6P Env and the same virus expressing SIV mac239 Gag. Seven monkeys received rMVA-HIV-189.6P Env and rMVA-SIVmac239 Gag, and another seven monkeys received rVac-HIV-1 89.6P Env and rVac-SIVmac239 Gag administered both i.d. and i.m. Another 28 monkeys received sham plasmid DNA and empty pox vectors (Santra et al., 2004).
Persistence levels were measured 2 weeks after challenge with results mentioned in Challenge Protocol section (Santra et al., 2004).
Control monkeys developed tetramer-binding CD8 T lymphocyte responses that were maximal 2 weeks after viral challenge and no detectable p41A-specific CD8 T cells. In contrast, all four groups of vaccinated monkeys developed robust secondary p11C-specific CTL responses that were comparable in magnitude. Animals boosted with plasmid DNA had Gag p11C-specific CD8 T cell responses similar in magnitude to that seen in the recombinant pox virus-boosted animals. Magnitudes of the postchallenge IFN ELISPOT responses to both vaccine antigens were comparable in all four experimentally vaccinated groups of monkeys. Therefore, although the pre-challenge peak vaccine-elicited immune responses were greater in the groups of monkeys boosted with recombinant pox vectors, the pre-challenge plateau and post-challenge peak secondary responses were equivalent in magnitude in all four experimental groups of animals (Santra et al., 2004).
Eighteen weeks after the final immunization, all animals were challenged with cell-free SHIV-89.6P i.v. (Santra et al., 2004).
There was a greater contraction of the vaccine-elicited IFN-γ-secreting T cell responses in the groups of monkeys boosted with recombinant pox vectors than in the group of animals boosted with plasmid DNA. Although the pre-challenge peak vaccine-elicited immune responses were greater in the groups of monkeys boosted with recombinant pox vectors, the pre-challenge plateau and post-challenge peak secondary responses were equivalent in magnitude in all four experimental groups of animals (Santra et al., 2004).
DNA vaccine expressing multiple HIV epitopes
VO_0000817
DNA vaccine
Auxo-GTU vector system [Ref319:Malm et al., 2005]
A significant limitation for HIV vaccine development is that there are no small animals in which actual productive HIV-1 infection can be established. DNA immunization with candidate vaccines comprising multiple genes of clades A, B, C, F, G, and H create strong cellular responses in BALB/c mice, especially after gene gun immunization (Malm et al., 2005).
A vaccine platform was constructed with an HIV-1 subtype B DNA immunogen expressing full-length consensus sequences from HIV-1 rev, nef, tat, and gag with additional cellular epitope clusters from the env and pol regions. Furthermore, this platform has been extended to three additional plasmids expressing the same immunogens but originating from subtypes A or C consensus or FGH ancestral sequences (Malm et al., 2005).
The antigens are named MultiHIV-A (based on the subtype A consensus sequence), MultiHIV-B (subtype B consensus sequence), MultiHIV-C, and MultiHIV-FGH (based on ancestral sequence for subtypes F, G, and H). The MultiHIV DNAs encode polypeptides consisting of a fusion of the full-length regulatory proteins Rev, Nef and Tat as well structural proteins p17 and p24 (Malm et al., 2005).
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
Though the immune response detected was quite low, the majority of g.g. immunized animals responded with specific IFN production. Interestingly, the gag specific response in the same gene gun immunized animals was weaker than the envelope responses and also drastically weaker than the responses seen before the experimental challenge (Malm et al., 2005). The CTL response, following i.d. injection, was detected five weeks after the first immunization and persisted up to 12 weeks later. In contrast, i.m. immunization induced detectable IFNy only at week 17 (Malm et al., 2005).
C57BL/6, BALB/c
C57BL/6 mice were divided into groups g.g. immunized or i.m. inoculated. Mice were bled 2 weeks after the last immunization, and individual blood and spleen samples were collected post-challenge and used fresh in ELISPOT assays (Malm et al., 2005).
BALB/c were immunized by MultiHIV/MultiClade DNA. Initially the immune response was evaluated after 3 immunizations by g.g. Equal amounts of clade A, B, C, and FGH MultiHIV plasmids were mixed together and coated onto the gold particles to construct the subtype cocktail MultiHIV DNA immunogen (MultiHIVmix). Mice were sacrificed 10 days after the last immunization and individual spleens were collected and the cells preserved at –70°C until used. In a second set of experiments a short-term immunization schedule was used to address three different administration routes; g.g., i.m., and i.d. Mice were immunized 3 times with MultiHIVmix DNA (Malm et al., 2005).
The vaccine-induced immunity has in vivo efficacy. Here a mouse model showed that the HIV-1 GTU-MultiHIVmix vaccine induces virus-specific CD8 T cellular immunity and protects against experimental HIV-1 challenge (Malm et al., 2005).
no side effects occurred (Malm et al., 2005)
C57BL/6 mice transgenic for HLA-A201 were given an experimental challenge after a short-term immunization schedule. Amphotropic murine leukemia virus was used to prepare pseudovirus with HIV-1 isolate. Challenged animals were given i.p. injections of sHIV-1/MuLV infected cells (Malm et al., 2005).
The cocktail of MultiHIV protected 19/24 animals against an experimental HIV-1 challenge. This experiment also demonstrates cross-clade protection, as the subtypes A and B viruses used for challenge were derived from different subtypes than the sequences found in the clade A or B specific MultiHIV constructs. Furthermore, it demonstrates that consensus approach used in Multi-HIVmix vaccine is functional and causes protection against naturally occurring isolates. Gene gun immunization was superior to intramuscular immunization in terms of both the T cell immunity induced, as well as higher frequency of protection. Data generated in this work support the hypothesis that DNA representing several HIV-1 subtypes and several genes are immunogenic and protective (Malm et al., 2005).
IFN-gamma levels in mice immunized by gene gun or intramuscular delivery with HIV-1 subtype B DNA immunogen showed strong up regulation in response to an H-2d restricted gag peptide (AMQMLKETI) and even stronger up-regulation in response to an env epitope (RGPGRAFVTI) (Malm et al., 2005).
Gag-VRPs
VO_0000822
VEE replicon particles (VRPs)
Gag-VRPs is a cocktail vaccine of V3014-packaged VRPs expressing the SIVsm H-4i nonmyristylated matrix-capsid region, full-length gp160, and a secreted form of gp160 (gp140). Structural proteins for packaging of replicon RNA into VRPs are expressed from separate helper RNAs. VRPs expressing either the matrix-capsid portion of Gag, the full-length envelope gp160, or the secreted gp140 of cloned SIVsm H-4i were mixed in a cocktail and used to immunize macaques (Davis et al., 2002).
HIV matrix-capsid portion of Gag, envelope gp160, secreted gp140, cloned SIVsm H-4i, SIVsm E660 (Davis et al., 2002)
In BALB/c mice, the two vectors elicited cellular immune responses to MA/CA as determined by bulk CTL assays and precursor frequency analysis, but the humoral response induced by the downstream vector was significantly stronger. These findings suggest that VEE vectors can be optimized to elicit strong, balanced and long-lived immune responses to foreign viral proteins (Caley et al., 1999).
BALB/c
VRPs with wild-type glycoprotein spikes were inoculated into the footpads of mice (Davis et al., 2002).
At 11 months post-boosting with the downstream vector, serum antibody levels against HIV MA/CA were undiminished, and MA/CA specific CTLp were detectable in all mice tested. These findings suggest that VEE vectors can be optimized to elicit strong, balanced and long-lived immune responses to foreign viral proteins (Caley et al., 1999).
Both humoral and cellular immune responses were induced. On the day of challenge, all vaccinated animals had neutralizing antibody to the homologous SIVsm H-4, most had CTL specific for Gag, Env, or both. The animals were followed for a period of 40 weeks postchallenge, and although vaccination did not prevent infection by the high dose IR challenge, several protective effects of vaccination were seen. Peak virus titers in plasma were reduced, and the range of peak titers was much smaller for the controls, suggesting that a clear protective effect against the acute phase of infection was induced in some of the vaccinated animals (Davis et al., 2002).
rhesus monkey (Macaca mulatta)
A cocktail vaccine of V3014-packaged VRPs expressing the SIVsm H-4i nonmyristylated matrix-capsid region, full-length gp160, and a secreted form of gp160 (gp140) was used to immunize rhesus macaques. Animals were given each VRP subcutaneously in the arm and later were challenged by the intrarectal (IR) route. Control animals received an equivalent dose of HA-VRPs (Davis et al., 2002).
Animals were followed for a period of 40 weeks postchallenge, and although vaccination did not prevent infection by the high dose IR challenge, several protective effects of vaccination were seen. Four of six vaccinated animals, as compared to one of six controls, showed virus loads below 1,700 copies per ml at the “set point” (23 weeks postchallenge). By 41 weeks postchallenge, when the experiment was terminated, there was a significant decrease in the mean plasma virus load in the vaccinated animals compared to that in the controls. Most vaccinated animals showed virus loads below the “set point” (23 weeks postchallenge). By 41 weeks postchallenge, when the experiment was terminated, there was a significant decrease in the mean plasma virus load in the vaccinated animals compared to that in the controls. Finally, the CD4C cells of the vaccinated animals were preserved and even increased postchallenge compared to those of the controls. In fact, in the vaccinated animals, there is a clear correlation between increased CD4C cells and lowered viral load (Davis et al., 2002).
No side effects were encountered (Davis et al., 2002).
Animals were given a dose of VRP subcutaneously in the arm and 1 month later were challenged by the intrarectal (IR) route. Control animals received an equivalent dose of HA-VRPs. The challenge virus was the highly virulent swarm SIVsm E660 (Davis et al., 2002).
gp120 recominant with GMDP adjuvant
VO_0004233
Subunit vaccine
Research
subcutaneous injection
subcutaneous injection
Recombinant HIV gp120 derived from CHO cells (Bomford et al., 1992).
Mice immunized with gp120 and GMDP in combination with pluronic emulsion resulted in a secondary antibody response (Bomford et al., 1992).
BALB/c
Mice were subcutaneously immunized with antigen and adjuvant (Bomford et al., 1992).
gp120 recominant with MDP adjuvant
VO_0004234
Subunit vaccine
Research
subcutaneous injection
subcutaneous injection
Recombinant HIV gp120 derived from CHO cells (Bomford et al., 1992).
Mice immunized with gp120 adjuvanted with MPD plus pleuronic emulsion resulted in a secondary antibody response (Bomford et al., 1992).
BALB/c
Mice were subcutaneously immunized with antigen and adjuvant (Bomford et al., 1992).
gp140, Gag and Tat Protein Vaccine with MF59
VO_0004238
Subunit vaccine
Research
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
gp140, Gag and Tat recombinant proteins (Bråve et al., 2007).
C57Bl/6
The protein vaccine component consisted of 20 μg ro-gp140 delivered in the right tibialis muscle and 20 μg rGag and 5 μg rTat delivered in the left tibialis muscle. The proteins were formulated in 50% MF59 solution. Mock treatment consisted of MF59 adjuvant alone or empty DNA plasmid alone (Bråve et al., 2007).
83% of mice were tested negative for HIV-1 after challenge (Bråve et al., 2007).
Briefly, 3 weeks after the final immunization (week 12), the animals were injected intraperitoneally with 1 million syngeneic splenocytes infected with HIV-1/MuLV of subtype B (LAI) (Bråve et al., 2007).
HIV DNA and adenoviral vector Ad5 expressing SIV gag protein
VO_0000786
DNA vaccine
Research
V1R plasmid and adenoviral vector (Ad5)
Intramuscular injection (i.m.)
Immunization and viral challenge studies were conducted in rhesus macaques (Macaca mulatta). Each of the test vectors expressed the identical SIVmac239 gag gene that had been codon optimized for expression in mammalian cells. The plasmid DNA vector was formulated in either PBS solution, a solution containing adjuvant, or a solution containing MPL/alum. All immunized animals were genotyped for the MHC class I Mamu-A*01 allele, allowing analysis of the responses of T cells (CD8+) to the test vaccines (Shiver et al., 2002).
CRL1005 for DNA vaccine (Shiver et al., 2002)
No virulence has been reported associated with this vaccine (Shiver et al., 2002).
The V1R DNA vector expressed the identical SIVmac239 gag gene that had been codon optimized for expression in mammalian cells (Shiver et al., 2002). The plasmid DNA vector was formulated in a solution containing a nonionic blocked copolymer adjuvant (CRL1005) (Shiver et al., 2002).
The adenoviral vector was based on a serotype 5 adenovirus that is incompetent to replicate with deletion of the E1 and E3 viral genes, and was propagated subsequently in E1-expressing 293 cells. Recombinant adenovirus expressing the codon-optimized SIV gag gene was then prepared. The recombinant adenovirus (Ad5-SIVgag) was grown in large quantities by multiple rounds of amplification in 293 cells. The virus was purified by caesium chloride gradient centrifugation (Shiver et al., 2002).
Intramuscular injection (i.m.)
SIVmac239 gag protein (Shiver et al., 2002)
Recombinant vector construction
DNA vaccine construction
In general, all of the monkeys developed p11CM-specific cellular immune responses after the initial immunization series. The p11CM (residues 181–189) is an immunodominant SIV gag epitope that is presented by the Mamu-A*01 MHC protein and is capable of binding T-cell receptors in the model monkeys. Administration of the third dose of the Ad5 vector resulted in an additional increase of p11CM-specific CD8+ T cells at the time of virus challenge. After the booster inoculation, these animals exhibited peak levels of p11CM-specific CD8+ T cells (Shiver et al., 2002).
rhesus monkey (Macaca mulatta)
This study used 14 monkeys, 3 each in the immunized groups and 8 in the unimmunized control group. Each of the test vectors expressed the identical SIVmac239 gag gene that had been codon optimized for expression in mammalian cells. The DNA vector priming inoculations were administered, followed by viral vector boost inoculations (Shiver et al., 2002).
Each of the animals in both control groups exhibited acute CD4+ T-cell lymphopenia and peak viral loads of viral RNA copies at about 3 weeks after challenge. All of the control monkeys experienced dramatic loss of CD4+ T cells. During the acute phase of the infection, most monkeys immunized with either the DNA or MVA vectors or with the DNA/CRL1005–MVA vector prime–boost combination exhibit an acute CD4+ T-cell lymphopenia. By about 70 d after challenge, many of the immunized monkeys exhibit some evidence of a positive immunization benefit, as manifested by control of viremia and recovery of CD4+ T-cell counts. However, the animals immunized with Ad5 vector exhibited the most pronounced attenuation of the infection with a pathogenic HIV–SIV hybrid virus (SHIV) (Shiver et al., 2002).
None of the vaccinated monkeys have yet exhibited any signs of immunodeficiency or suffered any consistent weight loss (Shiver et al., 2002).
At 6 weeks after the final immunization, all monkeys were challenged i.v. with the pathogenic HIV–SIV hybrid virus (SHIV) 89.6P16. The challenge of the control and immunized animals within the context of each of the two independent studies occurred concurrently (Shiver et al., 2002).
Levels of interferon-gamma in monkeys stimulated intramuscularly with either the p11CM peptide or a pool of peptides derived from SIV gag were significantly upregulated and correlated well with the tetramer-staining results after the final boost. Intracellular IFN-[gamma]-staining assays confirmed that these responses were primarily mediated by CD8+ T cells (Shiver et al., 2002).
HIV DNA vaccine Ad26/Ad5HVR48 encoding HIV or SIV env or gag
VO_0004342
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
Recombinant vector construction
This recombinant vector vaccine expressed env from HIV-1 (Barouch et al., 2012).
DNA vaccine construction
This recombinant vector vaccine expressed gag from HIV-1 (Barouch et al., 2012).
Recombinant vector construction
This recombinant vector vaccine expressed env from SIV (Barouch et al., 2012).
DNA vaccine construction
This recombinant vector vaccine expressed gag from SIV (Barouch et al., 2012).
VO_0000286
After the high-dose vaginal SHIV-162P3 challenge, 7/8 control animals were infected. Similarly, 7/8 animals in the vaccine-only group (group V) were infected. In the microbicide-only group (group M), 4/8 animals were infected. In the combination group (group V+M), only 2/7 animals were infected. The intervention efficacy in group V+M was 67%. In summary, the data supports that vaccines and microbicides used in combination may confer protection against sexual HIV-1 transmission to women by the vaginal route (Barouch et al., 2012).
HIV DNA vaccine pCMN160
VO_0004345
DNA vaccine
Research
pCMN160 [Ref2214:Boyer et al., 1997]
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
env and rev of HIV-1 strain MN and gag/pol from HIV-1 III8 (Boyer et al., 1997)
DNA vaccine construction
This DNA vaccine encoded env (Boyer et al., 1997).
DNA vaccine construction
This DNA vaccine encoded rev (Boyer et al., 1997).
DNA vaccine construction
This DNA vaccine encoded gag/pol from HIV-1 III8 (Boyer et al., 1997).
VO_0000286
Animals were challenged with a heterologous chimpanzee titered stock of HIV-1 SF2 virus. Polymerase chain reaction coupled with reverse transcription results indicated infection in the control animal, whereas those animals vaccinated with the DNA constructs were protected from the establishment of infection (Boyer et al., 1997).
HIV DNA vaccine pHIS-SHIV-B
VO_0004348
DNA vaccine
Research
pHIS-64 [Ref2227:Dale et al., 2004]
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
full-length unmutated SIVmac239 Gag and Pol, HIV-1AD8, Tat, Rev, and Vpu, and the 5′ third of HIV-1AD8 Env (Dale et al., 2004)
DNA vaccine construction
The DNA vaccine strain, pHIS-SHIV-B, encoded full-length unmutated SIVmac239 Gag and Pol, HIV-1AD8, Tat, Rev, and Vpu, and the 5′ third of HIV-1AD8 Env (Dale et al., 2004).
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
VO_0000286
DNA vaccination alone primed for protection almost as effectively as the DNA/fowlpox virus regimen (Dale et al., 2004).
SIV Gag-specific CD8 T cells expressing IFN-γ were dramatically boosted after challenge. Mean Gag-specific CD8 T cells peaked 3 weeks following challenge at 11.7% of all CD8 T cells in these outbred pigtail macaques immunized with the 2DNA/FPV regimen. The other vaccine groups had lower mean postchallenge CD8 T-cell responses, with peak responses at week 2 following challenge numbering 3.8% in the 3DNA group, 1.1% responses in the 1DNA/FPV group, and 2.0% in the 2DNA/FPV-IFN-γ-immunized animals (Dale et al., 2004).
HIV DNA vaccine SHIV-89.6 DNA (DNA/89.6)
VO_0004344
DNA vaccine
Research
pGA [Ref2205:Robinson et al., 2006]
Intramuscular injection (i.m.)
GM-CSF (Robinson et al., 2006)
Intramuscular injection (i.m.)
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
Co-delivery of GM-CSF and vaccine DNAs enhanced the temporal appearance of neutralizing Ab and broadened the specificity of the neutralizing activity to include SHIV-89.6P (Robinson et al., 2006).
VO_0000286
The GM-CSF-adjuvanted group showed a trend towards better control of the challenge infection and had better control of re-emergent virus (P < 0.01) than the non-adjuvanted group. After 52 weeks, the non-GM-CSF group continued to show some peaks of re-emergent virus whereas the GM-CSF group continued to maintain control below our level of detection (Robinson et al., 2006).
HIV DNA vaccine SIVmac239 Gag-Pol-Nef and mock Env with rAd5 boost
VO_0004349
DNA vaccine
Research
pVR1012 prime, rAd5 boost [Ref2230:Mascola et al., 2005]
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA priming-rAd5 boosting immunization platform can elicit potent anti-HIV-1 cellular immune responses and anti-HIV-1 neutralizing antibodies (Mascola et al., 2005).
VO_0000286
In a challenge study, all monkeys were immunized with DNA plasmids at 0, 4, and 8 weeks and boosted with rAd5 at week 26. Serial plasma dilutions were tested against four of the more neutralization-sensitive viruses, and the plasma dilution that produced 50% virus neutralization, which is required to protect 50% of the cells from virus-induced killing, was determined. The data clearly demonstrates that both the vaccine platform and these immunogens elicit IgG-mediated virus neutralization (Mascola et al., 2005).
HIV DNA vaccine VlJns-tPA-gp120
VO_0004351
DNA vaccine
Research
VlJns [Ref2235:Lekutis et al., 1997]
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
DNA vaccine construction
This vaccine encoded gp120 from HIV IIIB (Lekutis et al., 1997).
The secretion of IFN-y stimulated CD4+ Th cell lines and rgp120-stimulated PBL from the vaccinated monkeys suggest that an HIV-1 env plasmid DNA vaccine elicits a Thl-like immune response in primates as well as in rodents (Lekutis et al., 1997)
VO_0000286
The secondary immune response that arose after repeated plasmid DNA administration was Thl-like, suggesting that the nature of the DNA vaccine-elicited Th cell response was maturation dependent. Evidence from vaccinated nonhuman primates suggests that a vigorous Th cell response, including viral Ag-specific IFN-y production, may be a correlate of protection from HIV- 1 and Simian Human Immunodeficiency Virus infection (Lekutis et al., 1997)
HIV priming with DNA vaccine expressing HIV gp160 protein and boosted with Ad5/35 vector expressing the same protein
VO_0000789
DNA vaccine
pCAGGS and a replication-defective chimeric Ad5 vector with the Ad35 fiber (Ad5/35)
Replication-defective Ad5 HIV recombinants and replication-defective MVA elicit potent CD8+ T-cell responses and provide a high degree of protection in NHPs. The Ad5 (subgroup C) has well-defined biological properties and has been widely used as a vector for gene therapy and vaccine. The replication-defective Ad5 vector can easily be produced in high titers and is highly effective in boosting HIV-specific immunity. However, this virus uses CAR as its primary attachment receptor, which confers tropism for liver parenchymal cells. This raises important safety concerns. Thus, a replication-defective chimeric Ad5 vector with Ad type 35 fiber (Ad5/35) has been developed, which not only induces strong antigen-specific humoral and cellular immune responses and exhibits minimal hepatotoxicity in both mice and NHPs, but is also significantly less susceptible to the pre-existing Ad5 immunity than a comparable Ad5 vector (Xin et al., 2005).
This novel Ad5/35 vector showed minimal hepatotoxicity after intramuscular administration with the novel Ad5/35 vector (Xin et al., 2005).
A replication-defective chimeric Ad5 vector with the Ad35 fiber (Ad5/35) was prepared and used to express HIV Env gp160 protein. The product is named Ad5/35-HIV (Xin et al., 2005).
HIV Env gp160 protein (Xin et al., 2005)
Recombinant vector construction
An Ad5/35 vector was used to express HIV Env gp160 protein (Ad5/35-HIV) (Xin et al., 2005).
DNA vaccine construction
The DNA vaccine contained env and rev from HIV-1 IIIB (Xin et al., 2005).
DNA vaccine construction
The DNA vaccine contained env and rev from HIV-1 IIIB (Xin et al., 2005).
A detectable HIV-specific serum Ab response developed within 2 weeks of the first immunization. At 4 weeks post boosting, titers in excess of 1:50 000 were achieved. Similar results were observed in neutralizing Ab. A increase in the number of HIV-specific IFN-gamma-secreting T cells was also detected in the peripheral blood mononuclear cells (PBMCs). Boosting with Ad5/35-HIV vector further increased this T-cell response (Xin et al., 2005).
rhesus monkey (Macaca mulatta)
10^11 vp of Ad5/35-HIV vector was injected i.m. into two rhesus monkeys (2 years old, male) at weeks 0 and 8 (Xin et al., 2005).
Liver infection with Ad5 vector was 20- to 40-fold stronger than that with Ad5/35 vector. Ad5-Luc vector was two- and four-fold higher, respectively, than that of the monkeys that received the Ad5/35-Luc vector. The Ad5/35 recombinants exhibits minimal hepatotoxicity in non-human primates but is also significantly less susceptible to the pre-existing Ad5 immunity than a comparable Ad5 vector (Xin et al., 2005).
The animals immunized with Ad5/35-HIV vector developed a high-titered anti-gp160 antibody (Ab) response. The magnitude of this response was not significantly altered by preimmunization with the DNA-HIV vaccine. DNA-HIV vaccination alone generated a low level of HIV-specific serum Ab. HIV-specific neutralizing Ab was only detectable in the Ad5/35-HIV vaccinated mice and DNA prime/Ad5/35-HIV boosted mice. HIV-specific cellular immune responses persisted through 7 months after final immunization (Xin et al., 2005).
Mice were injected i.m. with Ad5-Luc or Ad5/35-Luc. Luciferase expression was monitored using an in vivo imaging system (IVIS). The expression of HIV gp160 was confirmed by Western blotting. Mice were immunized with Ad5/35-HIV vector, and the HIV-specific CMI was periodically monitored by the intracellular cytokine staining (ICS) assay (Xin et al., 2005).
The animals that were vaccinated with the Ad5/35 vector alone or in combination with the DNA-HIV vaccine were completely protected from infection; however, the DNA-HIV vaccination alone had little impact on the susceptibility to infection by vPE16. DNA-HIV vaccination by itself was not protective, but the combination of DNA-HIV priming and Ad5/35-HIV boosting yielded a prolonged and complete protection (Xin et al., 2005).
The hepatotoxicity caused by the Ad5 vector was circumvented by the use of an Ad5/35 vector (Xin et al., 2005).
Immunized mice were challenged with vPE16 2 weeks after final immunization. Vaccinated mice were challenged with vPE16 7 weeks after final immunization. The strain vPE16 is HIVBH8 gp160-expressing replication-competent vaccinia virus (WR strain, vPE16; HIVBH8 gp160 has 97.32% amino-acid homology with HIVIIIB gp160) (Xin et al., 2005).
HIV recombinant gp160 Protein Vaccine
VO_0004274
Subunit vaccine
Research
subcutaneous injection
subcutaneous injection
Recombinant gp160 (Barrett et al., 1989).
The highest potency in mice was obtained using a preparation with 0.2% Al(OH)3 and 0.25% deoxycholate (Barrett et al., 1989).
The potency of the vaccine was determined by injecting mice with serial dilutions of gp160 alone or adjuvanted with different formulations. Groups of 10 mice were injected subcutaneously with 1 ml of fourfold dilutions of the test substance. A total of 50 mice were injected in each test (Barrett et al., 1989).
HIV recombinant vector vaccine MVA-gag encoding gag
VO_0004347
Recombinant vector vaccine
Research
pSC59 [Ref2225:Casimiro et al., 2003].
Intramuscular injection (i.m.)
CRL1005 (Casimiro et al., 2003)
Intramuscular injection (i.m.)
Recombinant vector construction
This recombinant vector vaccine expressed gag from HIV-1 (Casimiro et al., 2003).
Immunization of macaques with MVA-gag resulted in relatively weak antigen-specific T-cell responses; the levels did not exceed 150 spot-forming cells (SFC)/106 PBMCs after three doses and were significantly less than those observed in the Ad5-gag vaccinees. Only one of six MVA-gag vaccinees elicited any detectable Gag-specific antibody response (140 mMU/ml at 4 weeks post-dose 3 for monkey V215) (Casimiro et al., 2003).
VO_0000286
The study reports that SIV Gag delivered by DNA, MVA, or adenovirus type 5 vectors is able to inhibit viral replication and disease progression in rhesus macaques following challenge with the SHIV89.6P virus. However, only 50% of the animals that received MVA alone or in combination with DNA were able to effectively control viremia (Casimiro et al., 2003).
HIV recombinant vector vaccine MVA.HIVA encoding env and rev
VO_0004350
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
Recombinant vector construction
This DNA vaccine encoded env from HIV-1 (Peters et al., 2007).
Recombinant vector construction
This DNA vaccine expressed rev from HIV-1 (Peters et al., 2007).
HIV-1 gp120 with mCT E112K
VO_0004268
Subunit vaccine
Research
intranasal immunization
intranasal immunization
HIV-1LAIEnv gp120 (Yoshino et al., 2004).
Macaques given nasal gp120 with either mCT E112K or nCT showed elevated gp120-specific IgG and IgA Ab responses with virus-neutralizing activity in both their plasma and mucosal external secretions, as well as higher numbers of gp120-specific IgA Ab-forming cells in their mucosal and peripheral lymphoid tissues and of IL-4-producing Th2-type CD4-positive (CD4(+)) T cells than did controls. Even though significant mucosal adjuvanticity was seen with both mCT E112K and nCT, neuronal damage was observed only in the nCT-treated, but not in the control or mCT E112K-treated groups (Yoshino et al., 2004).
rhesus macaques
Rhesus macaques were divided into four groups and nasally immunized with vaccine containing: 1) 100 µg of gp120 alone, 2) 100 µg of gp120 plus 10 µg of nCT, 3) 100 µg of gp120 plus 25 µg of mCT E112K, or 4) 100 µg of gp120 plus 100 µg of mCT E112K. Macaques were anesthetized with ketamine and placed in dorsal recumbancy with head tilted back so that the nares were pointed upward. Vaccine solution (0.5 ml) was instilled dropwise into each nostril without inserting the syringe into the nasal cavity. Macaques were kept in that position for 10 min and then placed in lateral recumbancy until they recovered from anesthesia, as described previously (16). Nasal immunization was conducted on days 0, 7, 14, 28, 42, and 56 (Yoshino et al., 2004).
Macaques given nasal gp120 with either mCT E112K or nCT showed significantly elevated IgA Ab responses with virus-neutralizing activity in both their plasma and mucosal external secretions, as well as higher numbers of gp120-specific IgA Ab-forming cells in their mucosal and peripheral lymphoid tissues compared to controls, who were vaccinated without the adjuvant (Yoshino et al., 2004).
Macaques given nasal gp120 with either mCT E112K or nCT showed significantly elevated gp120-specific IgG responses with virus-neutralizing activity in both their plasma and mucosal external secretions compared to controls, who were vaccinated without the adjuvant (Yoshino et al., 2004).
Vaccinated animals that received the adjuvant had a greater increase in IL-4-producing Th2-type CD4-positive (CD4(+)) T cells in mesenteric lymph nodes (MLNs) than did controls vaccinated without the adjuvant, which did not produce IL-4 (Yoshino et al., 2004),
HIV-2 DNA vaccine
VO_0004259
DNA vaccine
Research
pND-14 [Ref2023:Locher et al., 2004]
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
The DNA vaccine constructs were developed based on the gene sequences of the gp140 envelope, p55 Gag, Nef, and Tat proteins from the HIV-2UC2 isolate (GenBank accession number U38293) (Locher et al., 2004).
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
Each baboon was immunized four times with the experimental or control DNA constructs formulated with Vaxfectin. The time intervals were chosen to permit maturation of the immune response (Locher et al., 2004).
At 2 weeks post-HIV-2 challenge, viral loads ranged from 100 (below the threshold of detection) to 81,000 viral RNA copies in the plasma, with the lowest average viral loads in the group of baboons that received the HIV-2 DNA without the genetic adjuvants (a mean of 852 copies/ml), followed by the group of baboons the received the HIV-2 DNA and the genetic adjuvants (a mean of 2499 copies/ml) (Locher et al., 2004).
One month after the fourth immunization, the baboons were challenged twice (6 h apart) by the intravaginal route using 50 baboon infectious dosages (30,000 tissue culture infectious dosages) of HIV-2UC2/9429 for a total of 100 baboon infectious dosages. This virus isolate is a more virulent variant of the HIV-2UC2 isolate and was recovered from a baboon with an AIDS-like disease (Locher et al., 2004).
Inactivated HIV-2 Vaccine with PMMA
VO_0004242
Inactivated or "killed" vaccine
Research
subcutaneous injection
subcutaneous injection
Mice immunized with PMMA adjuvant had higher antibody counts than mice immunized with an alum adjuvant (Stieneker et al., 1991).
NMRI
Mice received 0.5 ml of the specified vaccine preparations subcutaneously under the abdominal skin on day 0 (Stieneker et al., 1991).
L. T -HIV-1 Gag
VO_0004629
Recombinant vector vaccine
Research
[Ref3082:Breton et al., 2007]
Intramuscular injection (i.m.)
A non-pathogenic protozoan parasitic vector, Leishmania tarentolae, which shares common target cells with HIV-1, was used to express full-length HIV-1 Gag protein (Breton et al., 2007).
Intramuscular injection (i.m.)
Recombinant vector construction
A non-pathogenic Leishmania tarentolae was used to express full-length HIV-1 Gag protein (Breton et al., 2007).
Immunization of BALB/c mice with recombinant L. tarentolae led to the expansion of HIV-1 Gag-specific T cells and stimulated CD8(+) T cells to produce gamma interferon in response to specific viral Gag epitopes. A booster immunization with recombinant L. tarentolae elicited effector memory HIV-1 Gag-specific CD4(+) T lymphocytes and increased antibody titres against HIV-1 Gag (Breton et al., 2007).
Balb/c
VO_0003057
Immunization of human tonsillar tissue cultured ex vivo with Gag-expressing L. tarentolae vaccine vector elicited a 75% decrease in virus replication following exposure of the immunized tonsils to HIV-1 infection (Breton et al., 2007).
MVA expressing HIV Gag, Pol and Env proteins
VO_0000824
Recombinant vector vaccine
modified vaccinia Ankara (MVA)
An rMVA vaccine that expresses HIV Gag, Pol, and Env proteins was constructed (Liu et al., 2006).
HIV Gag, Pol, and Env proteins (Liu et al., 2006)
CD8 T cells were boosted more effectively than CD4 T cells with the ratio of elicited CD8 to CD4 cells for the immunodominant CD8 epitope in Gag increasing with boosts. The most effective boost for CD8 T cells resulted in the greatest skewing of the CD8 to CD4 T cell ratio. This could represent better access of CD8 than CD4 T cells to APCs (Liu et al., 2006). The dose–response studies showed good increases for antigen expression with increasing MVA dose. A 1000-fold increase in the dose of MVA resulted in a 300-fold increase in the frequency of antigen-expressing cells. In contrast, dose–response studies for in vivo immunogenicity showed <10-fold increases in elicited T cells and Ab for 100–1000-fold increases in the dose of inoculated MVA. Shallow dose–response curves for immunogenicity were observed post priming as well as post boosting of an MVA or a DNA prime (Liu et al., 2006).
BALB/c
Female BALB/c mice were used for immunizations. All were conducted on anesthetized mice. Immunizations with MVAs were accomplished by inoculating the desired amount of MVA into a single quadriceps muscle. Immunizations with DNA were accomplished by injecting the desired amount of DNA into the quadriceps, half in each leg (Liu et al., 2006).
Temporal CD8 responses were conducted in BALB/c mice using MVA. Responses were steady for >10 weeks (>6 weeks post-MVA) (Liu et al., 2006).
No adverse effects were encountered (Liu et al., 2006).
NYVAC-HIV-1
VO_0004774
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
Attenuated poxvirus-HIV-1 recombinants followed by protein boosting (Patterson et al., 2000).
Intramuscular injection (i.m.)
Twenty-four macaques were primed with NYVAC (a genetically attenuated Copenhagen vaccinia strain) recombinants with HIV-1 and HIV-2 env and gag-pol or NYVAC vector alone and boosted with homologous, oligomeric gp160 proteins or adjuvant only (Patterson et al., 2000).
VO_0000287
Virological assessments verified that both NYVAC-HIV-1 and NYVAC-HIV-2 immunization significantly reduced viral burdens and partially protected against HIV-2 challenge, although cross-protection was not at the level that had been previously reported. Humoral antibody and/or CTL and CD8AA were associated with protection against homologous HIV-2 challenge, while cellular immune responses seemed more important for cross-protection. No significant protection was observed in the SHIV-challenged macaques (Patterson et al., 2000).
One half of each immunization and control group were intravenously challenged with SHIV(HXB2) the other half was challenged with HIV-2SBL6669 (Patterson et al., 2000).
NYVAC-HIV-2
VO_0004775
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
Attenuated poxvirus-HIV-1 recombinants followed by protein boosting (Patterson et al., 2000).
Intramuscular injection (i.m.)
Twenty-four macaques were primed with NYVAC (a genetically attenuated Copenhagen vaccinia strain) recombinants with HIV-1 and HIV-2 env and gag-pol or NYVAC vector alone and boosted with homologous, oligomeric gp160 proteins or adjuvant only (Patterson et al., 2000).
VO_0003057
Virological assessments verified that both NYVAC-HIV-1 and NYVAC-HIV-2 immunization significantly reduced viral burdens and partially protected against HIV-2 challenge, although cross-protection was not at the level that had been previously reported. Humoral antibody and/or CTL and CD8AA were associated with protection against homologous HIV-2 challenge, while cellular immune responses seemed more important for cross-protection. No significant protection was observed in the SHIV-challenged macaques, although NYVAC-HIV-1 immunization resulted in significantly lower viral burdens compared with controls (Patterson et al., 2000).
One half of each immunization and control group were intravenously challenged with SHIV(HXB2) the other half was challenged with HIV-2SBL6669 (Patterson et al., 2000).
NYVAC-SIV
VO_0004779
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
The gag, pol, and env genes of SIV(K6W) were expressed in the NYVAC vector (Benson et al., 1998).
Intramuscular injection (i.m.)
The macaques were immunized with NYVAC-SIV and NYVAC-IL-12 or NYVAC-SIV alone (Benson et al., 1998).
VO_0003057
Significantly, five of the eleven vaccinees exposed mucosally to SIV(mac251) showed a transient peak of viremia 1 week after viral challenge and subsequently appeared to clear viral infection. In contrast, all 12 animals inoculated intravenously became infected, but 5 to 6 months after viral challenge, 4 animals were able to control viral expression and appeared to progress to disease more slowly than control animals. Protection did not appear to be associated with any of the measured immunological parameters. Further modulation of immune responses by coadministration of NYVAC-cytokine recombinants did not appear to influence the outcome of viral challenge (Benson et al., 1998).
At the end of the immunization regimen, half of the animals were challenged with SIV(mac251) by the intravenous route and the other half were exposed to SIV(mac251) intrarectally (Benson et al., 1998).
rBCG-SIVgag and rDIsSIVgag Prime-boost SHIV vaccine
VO_0004600
Recombinant vector vaccine
Research
Mycobacterium bovis bacillus Calmette-Guérin (BCG)-Tokyo and a replication-deficient vaccinia virus strain (DIs) [Ref2794:Ami et al., 2005]
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
gag from simian immunodeficiency viruses
Recombinant vector construction
The SHIV gag gene was inserted to a recombinant BCG vector and a replication-deficient vaccinia virus strain (DIs) vaccine vector (Ami et al., 2005).
cynomologus macaque
cynomologus macaques were primed with rBCG-SIVgag, and then boosted with rDIsSIVgag (Ami et al., 2005).
VO_0003057
For the prime-boost vaccination group, plasma viremia levels remained undetectable and CD4+ T-cell counts stayed above 500 cells/μl for the entire year of testing (Ami et al., 2005).
Ten weeks after the second booster immunization, the macaques were challenged by intrarectal inoculation with 2 × 10^3 TCID50 or 50 50% monkey infectious doses (MID50) of SHIV KS661c, an SHIV-89.6 variant clone (Ami et al., 2005).
Recombinant HIV gp120 with adjuvant NanoEmulsion
VO_0000819
Subunit vaccine
An oil-in-water nanoemulsion (NE) (Bielinska et al., 2008).
The gp120 and NE vaccines were prepared by mixing NE with gp120 protein solution, using pyrogen-free saline as a diluent (Bielinska et al., 2008).
HIV glycoprotein 120, which has a role in facilitating coreceptor interaction and in mediating virus binding to cellular CD4 (Bielinska et al., 2008).
Immunized mice demonstrated robust serum anti-gp120 IgG, as well as bronchial, vaginal, and serum anti-gp120 IgA . The analysis of gp120-specific CTL proliferation, INF- induction, and prevalence of anti-gp120 IgG2 subclass antibodies indicated that nasal vaccination in NE also induced systemic, Th1-polarized cellular immune responses (Bielinska et al., 2008).
BALB/c
BALB/c mice were immunized with two or three intranasal administrations of gp120/NE formulation at 3 weeks apart. The immunizations of 10 microliters were performed by slowly applying gp120/NE mixes to the nares.Control mice were immunized with gp120 in saline, with NE alone or saline. Intramuscular immunization was performed with two doses, 3 weeks apart, of 20 micrograms of gp120 injected in 50 microliters of either saline or 1% NE (Bielinska et al., 2008).
Immunization produced significant levels of serum anti-gp120 IgG antibodies in all animals, as was seen with the mice. The analysis of gp120-specific CTL proliferation, INF gamma induction, and prevalence of anti-gp120 IgG2 subclass antibodies indicated that nasal vaccination in NE also induced systemic, Th1-polarized cellular immune responses (Bielinska et al., 2008).
Hartley
Hartley guinea pigs were immunized intranasally with two administrations (50 microliters per nare) of gp120/NE mix at 3 weeks apart (Bielinska et al., 2008).
rgp120 HIV Vaccine with immunoliposomes
VO_0004264
Subunit vaccine
Research
subcutaneous injection
subcutaneous injection
rgp120 (Ozpolat et al., 1998).
Mice vaccinated with immunoliposomes were found to have a strong delayed-type hypersensitivity (DTH) response to the weakly immunogenic gp120 that was dependent on the presence of the MAbs. However, this vaccination protocol did not induce humoral immunity (Ozpolat et al., 1998).
C3H/HeN
Groups of five mice were immunized subcutaneously three times at 14-day intervals. The immunoliposomes were suspended in PBS and each mouse received 0.1 ml per injection. Each injection contained 380 μg of PC, 193 μg of CH, 10 pg of PE-B, 2.0 μg of MAb, and 10 μg of rgpl20 (Ozpolat et al., 1998).
rMVA-SIV-CD40L
VO_0004792
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
Co-expressed the CD40L with our DNA/SIV vaccine such that the CD40L is anchored on the membrane of SIV virus-like particle (VLP) (Kwa et al., 2014).
Intramuscular injection (i.m.)
The macaques were divided into 3 groups and group 1 was vaccinated with a DNA/MVA SIV vaccine, group 2 was vaccinated with the DNA/MVA SIV vaccine with CD40L in the DNA, and the third group was an unvaccinated control (Kwa et al., 2014).
VO_0003057
CD40L adjuvant enhanced the functional quality of anti-Env antibody response and breadth of anti-SIV CD8 and CD4 T cell responses, significantly delayed the acquisition of heterologous mucosal SIV infection and improved viral control. Notably, the CD40L adjuvant enhanced the control of viral replication in the gut at the site of challenge that was associated with lower mucosal CD8 immune activation, one of the strong predictors of disease progression (Kwa et al., 2014).
The macaques were intrarectally challenged with SIVE660 at a dose of 5000 TCID to test the level of protection of the vaccines (Kwa et al., 2014).
rMVTT-SIV-gpe
VO_0004760
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
(Sun et al., 2013) a modified replicating vaccinia virus Tiantan strain (MVTT(SIVgpe))
Intramuscular injection (i.m.)
Recombinant vector construction
A recombinant modified replicating vaccinia virus Tiantan strain (MVTTSIVgpe) and a recombinant, nonreplicating adenovirus type 5 strain (Ad5SIVgpe) expressing the SIVmac239 Gag, Pol, and Env structural proteins were generated (Sun et al., 2013).
Recombinant vector construction
A recombinant modified replicating vaccinia virus Tiantan strain (MVTTSIVgpe) and a recombinant, nonreplicating adenovirus type 5 strain (Ad5SIVgpe) expressing the SIVmac239 Gag, Pol, and Env structural proteins were generated (Sun et al., 2013).
Recombinant vector construction
A recombinant modified replicating vaccinia virus Tiantan strain (MVTTSIVgpe) and a recombinant, nonreplicating adenovirus type 5 strain (Ad5SIVgpe) expressing the SIVmac239 Gag, Pol, and Env structural proteins were generated (Sun et al., 2013).
Eight monkeys were divided into two groups: (i) four monkeys received the MVTTioin+Adim testing regimen as in study I, and (ii) four monkeys received an empty MVTT control vector (10^9 PFU) through intraoral (0.5 ml) and intranasal (0.5 ml) routes and an empty Ad5 control vector (10^11 vp in 1 ml of PBS) through intramuscular injection (Sun et al., 2013).
VO_0003057
The reductions in peak and set-point viral loads were significant in most animals, with one other animal being protected fully from high-dose intrarectal inoculation of SIV(mac239). Furthermore, the animals vaccinated with this regimen were healthy, while ~75% of control animals developed simian AIDS. The protective effects correlated with the vaccine-elicited SIV-specific CD8(+) T cell responses against Gag and Pol (Sun et al., 2013).
At either week 30 after the initial vaccination or week 24 after the final vaccination, each animal was challenged intrarectally with 5 × 10^5 50% tissue culture infective doses (TCID50) of Chinese rhesus monkey-adapted and neutralization-resistant SIVmac239. In all cases, the challenge virus stock was administered in 1 ml of PBS (Sun et al., 2013).
SHIV DNA vaccine encoding env and gag
VO_0004596
DNA vaccine
Research
pSW3891 [Ref2784:Pal et al., 2006]
Gene gun
Gene gun
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
VO_0003057
The immune response elicited by the multivalent DNA prime/protein boost vaccine was able to protect macaques from rectal challenge with SHIV-Ba-L isolate. This polyvalent vaccine formulation was able to confer protection in four out of six animals against SHIV-Ba-L and significantly reduced plasma viremia in the two remaining animals (Pal et al., 2006).
SHIV(Ba-L) DNA vaccine encoding env and gag
VO_0004597
DNA vaccine
Research
pSW3891 [Ref2786:Pal et al., 2005]
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
DNA vaccine construction
VO_0003057
one of six immunized animals was completely protected whereas all six naïve animals were infected. These results demonstrate that a vaccine based on priming with a polyvalent DNA vaccine from multiple HIV-1 subtypes followed by boosting with homologous Env proteins elicits anti-HIV-1 immune responses capable of controlling rectal transmission of SHIV(Ba-L) (Pal et al., 2005).
V3 VLPs with Gamma inulin adjuvant
VO_0004232
Subunit vaccine
Research
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
gp120 V3 loop (Harris et al., 1996).
Mice immunized with V3 VLPs adjuvanted with gamma inulin showed good CTL responses (Harris et al., 1996).
BABL/c
Mice were immunized with 10 μg of V3-VLPs without adjuvant in the muscle of the left leg. At the same time, the mice were immunized in the right leg with the other immunogens (Harris et al., 1996).
YF17D- HIV-1 p24
VO_0004690
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
HIV-1 p24 (clade B consensus), was inserted near the 5' end of YF17D, in frame and upstream of the polyprotein (YF-5'/p24) (Franco et al., 2010).
Intramuscular injection (i.m.)
Mice were immunized two times subcutaneously at the base of the tail with PBS or 10^6 pfu of YF17D, YF-E/p24/NS1, or YF-5′/p24 in 100 μl on days 0 and 14 (Franco et al., 2010).
VO_0003057
The protective efficacy of the YF17D recombinants, particularly YF-E/p24/NS1, in mice challenged with a vaccinia expressing HIV-1 Gag was demonstrated (Franco et al., 2010).
Three weeks after the second immunization, half of the mice in each group were challenged intranasally with 5 × 10^5 pfu of Gag-expressing recombinant vaccinia virus (Vac-gag). The remaining animals in the groups were challenged intranasally with the same dose of wild-type vaccinia virus (Vac-wt) (Franco et al., 2010).
env
Human immunodeficiency virus 1
VO_0010937
8218033
CDD:278917
CDD:295533
CDD:197369
GOA:Q9IBN3
HSSP:1MEQ
InterPro:IPR000328
InterPro:IPR000777
UniProtKB/TrEMBL:Q9IBN3
11676
?
ENV (gp160)
8.84
92355.68
920
HIV-1 GB8 isolated into the cell line JM and the provirus clone was derived by PCR off extracted high molecular weight DNA
>gi|8218025:6237-8786 Human immunodeficiency virus type 1 proviral genome, isolate GB8, clone 46R
ATGAAAGCGAAGGGGACCAGGAAGAATTATCAGCACTTGTGGAAATGGGGCATCATGCTCCTTGGGATGT
TGATGATCTGTAGTGCTACAGAAAAATTGTGGGTCACAGTCTATTATGGGGTACCTGTGTGGAAAGAAGC
AACCACCACTCTATTTTGTGCATCAGATGCTAAAGCATATGACACAGAAAAACATAATGTTTGGGCCACA
CATGCCTGTGTACCCACAGACCCCAACCCACAAGAGGTAGTATTGGGAAATGTGACAGAAAATTTTAACA
TGTGGAAAAATAACATGGTAGAACAGATGCATGAGGATATAATCAGTTTATGGGATCAAAGCCTAAAGCC
ATGTGTAAAATTAACCCCACTCTGTGTTACTTTAAATTGCACTGATTTGAGGAATGATACTAATACCGAT
AATAGTATAATGGAGGGAGGAGAAATGAAAAACTGCTCTTTCAATATCACCACAAGCATAAGGGATAAGA
TGCAGAAAGAATATGCACTTTTGTATAAACTTGATATAGTATCAATAGGTAGTGATAATACTAGCTATAT
ATTGACAAAGTGTGACGCCTCAGTCATTACACAGGCCTGTCCAAAGATATCCTTTGAGCCAATTCCCATA
CATTTTTGTGCCCCGGCTGGTTTTGCGATTCTAAAGTGTAACAATAAGACATTCGATGGAAAAGGACCAT
GTACAAATGTCAGCACAGTACAATGTACACATGGAATTAGGCCAGTAGTGTCAACTCAACTGCTGTTAAA
TGGCAGTCTAGCAGAAGAAAAGGTAGTAATTAGATCTGACAATTTCATGGACAATACTAAAACCATAATA
GTACAGCTGAAAGAAGCTGTAGAAATTAATTGTACAAGACCCAACAACAATACAAGAAAAGGTATATACA
TAGGACCAGGGAGAAGATTTTATACAACAGGAAGAATAATAGGAGATATAAGACAAGCACATTGTAACAT
TAGTAAAGAAAAATGGAATAATACTTTACACCAGATAGTTATAGAATTGAGGAAACAATTTAGGAATAAA
ACAATAGTCTTTAATCAATCCTCAGGAGGGGACCCAGAAATTGTAATGCACAGTTTTAATTGTGGAGGGG
AATTTTTCTACTGTAAGACAGCACAACTGTTTAATAGTACTTGGAATAGTACTGGAAATGGTACTATAAA
GTCAAATACCACTGAAATTATCACACTCCCATGTAGAATAAAACAAATTGTAAACATGTGGCAGGAAGTA
GGAAAAGCAATGTATGCCCCTCCCATCACAGGACAAATTAGATGTGCATCACATATTACAGGGCTACTAT
TAACAAGAGATGGAGGTAGGGAGAACAATACCAACGAGACCGAGACCTTCAGACCTGGAGGAGGAGATAT
GAGGGACAATTGGAGAAGTGAATTATATAAATATAAAGTAGTAAAAATTGAACCATTAGGAGTAGCACCC
ACCAAGGCAAAGAGAAGAGTGGTGCAGAGAGAAAAAAGAGCAGTGGGAATGATAGGAGCTATGTTCCTTG
GGTTCTTGGGAGCAGCAGGAAGCACTATGGGCGCAGCGTCACTGACGCTGACGGTACAGGCCAGACTATT
ATTGTCTGGTATAGTGCAACAGCAAAATAATTTGCTGAGGGCTATTGAGGCGCAACAGCATCTGTTGCGA
CTCACAGTCTGGGGCATCAAGCAGCTCCAGGCAAGAGTCCTGGCTGTGGAAAGATACCTAAAGGATCAAC
AGCTCCTAGGGATTTGGGGTTGCTCTGGAAAACTCATTTGCACCACTACTGTGCCTTGGAATGTTAGTTG
GAGTAATAAATCTCTGGATAAGATTTGGAATAACATGACCTGGATGGAGTGGGAAAGAGAAATTGACAAT
TACACAAACACAATATACACCTTAATTGAAGAATCGCAGAACCAACAAGAAAAGAATGAACAAGAATTAT
TGGAATTGGATAAGTGGGCAAATTTGTGGAATTGGTTTGACATAACAAACTGGCTGTGGTATATAAAAAT
ATTCATAATGATAATAGGAGGCTTAATAGGTTTAAGAATAATTTTTGCTGTAATTTCTATAGTGAATAGA
GTTAGGCGGGGATACTCACCATTATCATTGCAGACCCACCTCCCAACCCCAAGGGGACCCGACAGGCCCG
AAGGAATCGAAGAAGAAGGTGGAGAGCAAGACAGAGACAGATCCATCAGATTGGTGAATGGATTCTTAGC
GCTTTTCTGGGACGACCTGCGGAGCCTGTGCCTCTTCAGCTACCACCGATTGAGAGACTTACTCTTGATT
GTGACGAGGATTGTGGGACTTCTGGGACGCAGGGGGTGGGAAGCCCTCAAGTATTGGTGGAATCTCCTGC
AGTATTGGATCCAGGAACTAAAGAATAGTGCTATTAGCTTGCTTAATACCACAGCTATAGCAGTAGCTGA
GGGGACAGATAGGGTTATAGAAGTAGTACAAAGAGCTTATAGAGCTATTCTCCACATACCTACAAGAATA
AGACAGGGCTTAGAAAGGGCTTTGCAATAA
>CAB92793.1 ENV (gp160) [Human immunodeficiency virus 1]
MKAKGTRKNYQHLWKWGIMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEKHNVWAT
HACVPTDPNPQEVVLGNVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDLRNDTNTD
NSIMEGGEMKNCSFNITTSIRDKMQKEYALLYKLDIVSIGSDNTSYILTKCDASVITQACPKISFEPIPI
HFCAPAGFAILKCNNKTFDGKGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEKVVIRSDNFMDNTKTII
VQLKEAVEINCTRPNNNTRKGIYIGPGRRFYTTGRIIGDIRQAHCNISKEKWNNTLHQIVIELRKQFRNK
TIVFNQSSGGDPEIVMHSFNCGGEFFYCKTAQLFNSTWNSTGNGTIKSNTTEIITLPCRIKQIVNMWQEV
GKAMYAPPITGQIRCASHITGLLLTRDGGRENNTNETETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAP
TKAKRRVVQREKRAVGMIGAMFLGFLGAAGSTMGAASLTLTVQARLLLSGIVQQQNNLLRAIEAQQHLLR
LTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKLICTTTVPWNVSWSNKSLDKIWNNMTWMEWEREIDN
YTNTIYTLIEESQNQQEKNEQELLELDKWANLWNWFDITNWLWYIKIFIMIIGGLIGLRIIFAVISIVNR
VRRGYSPLSLQTHLPTPRGPDRPEGIEEEGGEQDRDRSIRLVNGFLALFWDDLRSLCLFSYHRLRDLLLI
VTRIVGLLGRRGWEALKYWWNLLQYWIQELKNSAISLLNTTAIAVAEGTDRVIEVVQRAYRAILHIPTRI
RQGLERALQ
Protective antigen
env
Human immunodeficiency virus 1
155971
9629363
HIV1gp8
AF033819
NP_057856
11676
5770
8340
+
Envelope surface glycoprotein gp160, precursor
9.19
91753.45
856
>NC_001802.1:5770-8340 Human immunodeficiency virus 1, complete genome
AATGAGAGTGAAGGAGAAATATCAGCACTTGTGGAGATGGGGGTGGAGATGGGGCACCATGCTCCTTGGG
ATGTTGATGATCTGTAGTGCTACAGAAAAATTGTGGGTCACAGTCTATTATGGGGTACCTGTGTGGAAGG
AAGCAACCACCACTCTATTTTGTGCATCAGATGCTAAAGCATATGATACAGAGGTACATAATGTTTGGGC
CACACATGCCTGTGTACCCACAGACCCCAACCCACAAGAAGTAGTATTGGTAAATGTGACAGAAAATTTT
AACATGTGGAAAAATGACATGGTAGAACAGATGCATGAGGATATAATCAGTTTATGGGATCAAAGCCTAA
AGCCATGTGTAAAATTAACCCCACTCTGTGTTAGTTTAAAGTGCACTGATTTGAAGAATGATACTAATAC
CAATAGTAGTAGCGGGAGAATGATAATGGAGAAAGGAGAGATAAAAAACTGCTCTTTCAATATCAGCACA
AGCATAAGAGGTAAGGTGCAGAAAGAATATGCATTTTTTTATAAACTTGATATAATACCAATAGATAATG
ATACTACCAGCTATAAGTTGACAAGTTGTAACACCTCAGTCATTACACAGGCCTGTCCAAAGGTATCCTT
TGAGCCAATTCCCATACATTATTGTGCCCCGGCTGGTTTTGCGATTCTAAAATGTAATAATAAGACGTTC
AATGGAACAGGACCATGTACAAATGTCAGCACAGTACAATGTACACATGGAATTAGGCCAGTAGTATCAA
CTCAACTGCTGTTAAATGGCAGTCTAGCAGAAGAAGAGGTAGTAATTAGATCTGTCAATTTCACGGACAA
TGCTAAAACCATAATAGTACAGCTGAACACATCTGTAGAAATTAATTGTACAAGACCCAACAACAATACA
AGAAAAAGAATCCGTATCCAGAGAGGACCAGGGAGAGCATTTGTTACAATAGGAAAAATAGGAAATATGA
GACAAGCACATTGTAACATTAGTAGAGCAAAATGGAATAACACTTTAAAACAGATAGCTAGCAAATTAAG
AGAACAATTTGGAAATAATAAAACAATAATCTTTAAGCAATCCTCAGGAGGGGACCCAGAAATTGTAACG
CACAGTTTTAATTGTGGAGGGGAATTTTTCTACTGTAATTCAACACAACTGTTTAATAGTACTTGGTTTA
ATAGTACTTGGAGTACTGAAGGGTCAAATAACACTGAAGGAAGTGACACAATCACCCTCCCATGCAGAAT
AAAACAAATTATAAACATGTGGCAGAAAGTAGGAAAAGCAATGTATGCCCCTCCCATCAGTGGACAAATT
AGATGTTCATCAAATATTACAGGGCTGCTATTAACAAGAGATGGTGGTAATAGCAACAATGAGTCCGAGA
TCTTCAGACCTGGAGGAGGAGATATGAGGGACAATTGGAGAAGTGAATTATATAAATATAAAGTAGTAAA
AATTGAACCATTAGGAGTAGCACCCACCAAGGCAAAGAGAAGAGTGGTGCAGAGAGAAAAAAGAGCAGTG
GGAATAGGAGCTTTGTTCCTTGGGTTCTTGGGAGCAGCAGGAAGCACTATGGGCGCAGCCTCAATGACGC
TGACGGTACAGGCCAGACAATTATTGTCTGGTATAGTGCAGCAGCAGAACAATTTGCTGAGGGCTATTGA
GGCGCAACAGCATCTGTTGCAACTCACAGTCTGGGGCATCAAGCAGCTCCAGGCAAGAATCCTGGCTGTG
GAAAGATACCTAAAGGATCAACAGCTCCTGGGGATTTGGGGTTGCTCTGGAAAACTCATTTGCACCACTG
CTGTGCCTTGGAATGCTAGTTGGAGTAATAAATCTCTGGAACAGATTTGGAATCACACGACCTGGATGGA
GTGGGACAGAGAAATTAACAATTACACAAGCTTAATACACTCCTTAATTGAAGAATCGCAAAACCAGCAA
GAAAAGAATGAACAAGAATTATTGGAATTAGATAAATGGGCAAGTTTGTGGAATTGGTTTAACATAACAA
ATTGGCTGTGGTATATAAAATTATTCATAATGATAGTAGGAGGCTTGGTAGGTTTAAGAATAGTTTTTGC
TGTACTTTCTATAGTGAATAGAGTTAGGCAGGGATATTCACCATTATCGTTTCAGACCCACCTCCCAACC
CCGAGGGGACCCGACAGGCCCGAAGGAATAGAAGAAGAAGGTGGAGAGAGAGACAGAGACAGATCCATTC
GATTAGTGAACGGATCCTTGGCACTTATCTGGGACGATCTGCGGAGCCTGTGCCTCTTCAGCTACCACCG
CTTGAGAGACTTACTCTTGATTGTAACGAGGATTGTGGAACTTCTGGGACGCAGGGGGTGGGAAGCCCTC
AAATATTGGTGGAATCTCCTACAGTATTGGAGTCAGGAACTAAAGAATAGTGCTGTTAGCTTGCTCAATG
CCACAGCCATAGCAGTAGCTGAGGGGACAGATAGGGTTATAGAAGTAGTACAAGGAGCTTGTAGAGCTAT
TCGCCACATACCTAGAAGAATAAGACAGGGCTTGGAAAGGATTTTGCTATA
>NP_057856.1 Envelope surface glycoprotein gp160, precursor [Human immunodeficiency virus 1]
MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWA
THACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLKNDTNT
NSSSGRMIMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLDIIPIDNDTTSYKLTSCNTSVITQACPKVSF
EPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSVNFTDN
AKTIIVQLNTSVEINCTRPNNNTRKRIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNNTLKQIASKLR
EQFGNNKTIIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRI
KQIINMWQKVGKAMYAPPISGQIRCSSNITGLLLTRDGGNSNNESEIFRPGGGDMRDNWRSELYKYKVVK
IEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQARQLLSGIVQQQNNLLRAIE
AQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSGKLICTTAVPWNASWSNKSLEQIWNHTTWME
WDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFA
VLSIVNRVRQGYSPLSFQTHLPTPRGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHR
LRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGACRAI
RHIPRRIRQGLERILL
Protective antigen
env
Human immunodeficiency virus 1 MN
3342812
CDD:278917
CDD:295533
CDD:197369
11676
?
envelope glycoprotein
8.75
92117.65
938
MN neutralization phenotype variant clone
>AAC31819.1 envelope glycoprotein [Human immunodeficiency virus 1]
MRVKGIRRNYQHWWGWGTMLLGLLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEAHNVWAT
HACVPTDPNPQEVELVNVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDLRNTTNTN
NSTDNNNSNSEGTIKGGEMKNCSFNITTSIGDKVQKEYALLYKLDIESIDNDSTSYRLISCNTSVITQAC
PKISFEPIPIHYCAPAGFAILKCNDKKFSGKGSCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSE
DFTDNAKTIIVHLKESVQINCTRPNYNKRKRIHIGPGRAFYTTKNIKGTIRQAHCIISRAKWNDTLRQIV
SKLKEQFKNKTIVFNPSSGGDPEIVMHSFNCGGEFFYCNTSPLFNSTWNGNNTWNNTTGSNNNITLQCKI
KQIINMWQKVGKAMYAPPIEGQIRCSSNITGLLLTRDGGIDTDTNDTEIFRPGGGDMRDNWRSELYKYKV
VTIEPLGVAPTKAKRRVVQREKRAAIGALFLGFLGAAGSTMGAASVTLTVQARPLLSGIVQQQNNLLRAI
ESQQHMLQLTVWGIKQLQARVLAVERYLKDQQLLGFWGCSGKLICTTTVPWNASWSNKSLDDIWNNMTWM
QWEREIDNYTSLIYSLLEKSQTQQEKNEQELLELDKWASLWNWFDITNWLWYIKIFIMIVGGLVGLRIVF
AVLSIVNRVRQGYSPLSLQTRPPVPRGPDRPEGIEEEGGERDRDTSGRLVHGFLAIIWVDLRSLFLLSYH
HLRDLLLIAARIVELLGRRGWEVLKYWWNLLQYWSQELKSSAVSLLNAAAIAVAEGTDRVIEVLQRAGRA
ILHIPTRIRQGLERALL
Protective antigen
env
Simian-Human immunodeficiency virus strain SHIV89.6P
72398919
CDD:278917
57667
?
envelope protein
9.92
40473.44
461
Envelope glycoprotein GP120; pfam00516
>AAZ72871.1 envelope protein, partial [Simian-Human immunodeficiency virus]
LNCTNLNITKNTTNPTSSSWGMMEEGEIKNCSFYITTSIRDKVKKEYALFNRLDVVPVENTSYRLISCNT
SVITQACPKVSFQPIPIHYCVPAGFAILKCNNKTFNGSGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEE
DIVIRSENFTNNVKNIIVQLNESVVINCTRPNNNTRERLSIGPGRAFYARRNIIGDIRQAHCNISRAKWN
NTLQQIVIKLREKYRNKTIAFNQSSGGDPEIVMHSFNCGGEFFYCNTAQLFNSTWNVTGGTNGTKGSDII
TLQCRIKQIINMWQKVGKAMYAPPIKGQIRCSSNITGLLLTRDGGSSTETEPEIFRPGGGDMRDNWRSEL
YKYKVVRIEPIGVAPTRAKRRTVQREKR
Protective antigen
env
Simian-Human immunodeficiency virus strain SHIV-89.6
2828045
CDD:278917
CDD:295533
CDD:197369
57667
?
env
9.04
91775.38
922
Envelope glycoprotein GP120; pfam00516
>AAB99966.1 env [Simian-Human immunodeficiency virus]
MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWREATTTLFCASDAKAYDTEVHNVWA
THACVPTDPNPQEVVLGNVTENFNMWKNNMVDQMHEDIISLWDESLKPCVKLTPLCVTLNCTNLNITKNT
TNPTSSSWGMMEKGEIKNCSFYITTSIRNKVKKEYALFNRLDVVPIENTNNTKYRLISCNTSVITQACPK
VSFQPIPIHYCVPAGFAMLKCNNKTFNGSGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEDIVIRSENF
TDNAKTIIVQLNESVVINCTRPNNNTRRRLSIGPGRAFYARRNIIGDIRQAHCNISRAKWNNTLQQIVIK
LREKFRNKTIAFNQSSGGDPEIVMHSFNCGGEFFYCNTAQLFNSTWNVTGGTNGTEGNDIITLQCRIKQI
INMWQKVGKAMYAPPITGQIRCSSNITGLLLTRDGGNSTETETEIFRPGGGDMRDNWRSELYKYKVVRIE
PIGVAPTRAKRRTVQREKRAVGIGAVFLGFLGAAGSTMGAASVTLTVQARLLLSGIVQQQNNLLRAIEAQ
QHMLQLTVWGIKQLQARVLALERYLRDQQLMGIWGCSGKLICTTSVPWNVSWSNKSVDDIWNNMTWMEWE
REIDNYTDYIYDLLEKSQTQQEKNEKELLELDKWASLWNWFDITNWLWYIRLFIMIVGGLIGLRIVFAVL
SIVNRVRQGYSPLSFQTLLPASRGPDRPEGTEEEGGERDRDRSGPLVNGSLALIWDDLRSLCLFSYHRLR
DLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGACRAIRH
IPRRIRQGLERILL
Protective antigen
env
Human immunodeficiency virus 2
1845209
CDD:278917
CDD:278918
CDD:197369
11709
?
envelope polyprotein
8.65
93936.04
945
similar to HIV2BEN, GenBank Accession Number M30502, and to HIV2D194, GenBank Accession Number J04542
>AAB47784.1 envelope polyprotein [Human immunodeficiency virus 2]
MEPGRNQLLAVILLTSACLIYCKQYVTVFYGVPVWRNASIPLFCATKNRDTWGTIQCLPDNDDYQEIPLN
VTEAFDAWDNTVTEQAIEDVWRLFETSIKPCVKLTPLCVAMNCNPVTGNNTNATAKPTAARPTTNPSYLT
IINESSTCVGADNCTGLGDEGMVNCKFNMTGLEQDKIKGYTDTWYSDDVVCDSTNKTGTNTTCYMRHCNT
SVIKESCDKHYWDSMKFRYCTPPGYALLRCNDTNYSGFAPNCPKVVAASCTRMMETQTSTWFGFNGTRAE
NRTYIYWHGRDNRTIISLNKHYNLTMHCKRPGNKTVVPITLMSGHRFHSQAVINKKPRQAWCWFKGNWKG
AMQEVKQTLAGHPRYKGTNDTSKINFVKPGVGSDPEVTYMWTNCRGEFFYCNMTWFLNWVENRTSQKQRN
YAPCHIRQIINTWHKVGQYVYLPPREGELTCNSTVTSIIANIDTDGNQTNITFSAEVAELYRLELGDYKL
IEITPIGFAPTSEKRYSSAPARNKRGVFVLGLLGFLATAGSAMGAASLTLSAQSRTLLAGIVQQQQQLLD
IVKRQQELLRLTVWGTKNLQARVTAIEKYLKDQAQLNSWGCTFRQVCHTTVPWVNDSLTPRWNNMTWQEW
EKQVRYLEANISQSLEEAQIQQEKNMYELQKLNSWDVFGNWFDLTSWIKYIQYGVYIVVGIIALRIAIYV
VQLLSRFRKGYRPVFSSPPGYLQQIHIHTDRGQPANEETEGDAGDASGYDFWPWPINYIQLLIHLLTRLL
TGLYSICRDLLSANSPTRRLISQNLTAIRDWLRLKAAYLQYGCEWIQEAFQAIARTARETLAGAWRGLCK
AVQRIGRGILAVPRRIRQGAEIALL
Protective antigen
env
Human immunodeficiency virus 1 isolate 715 from Baltimore clone 6
475647
CDD:278917
CDD:295533
CDD:197369
11676
?
envelope glycoprotein
8.4
91460.08
942
Envelope glycoprotein GP120; pfam00516
>AAB04079.1 envelope glycoprotein, partial [Human immunodeficiency virus 1]
VTGIRKNCQHWWKWGIMLLGILMICNATEKLWVTVYYGVPVWKEANTTLFCASDAKAYDTEVHNVWATHA
CVPTDPDPQEVELENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTNLRNDTNTTRN
ATNTTSSETMMEEGEIKNCSFNITTSIRDKVQKEFALFYKLDVVPIENDTTSYRLISCNTSVLTQACPKV
SFEPIPIHFCAPAGFAILKCKDKKFNGTGPCTNVSTVQCTHGIKPVVSTQLLLNGSLAEEEVVIRSANLS
DNAKTIIVQLNESVQMNCTRPNNNTRKSIHIGPGRAFYTTGEIIGDIRQAHCNLSRTKWNETLKRIVIKL
REQYENKTIVFNQSSGGDPEIVMLSFNCGGEFFYCNSTKLFNSTWNGTESNNTGDDPIVLPCRIKQVINM
WQEVGKAMYAPPIRGQIRCSSNITGLLLTRDGGNSNETNTTEIFRPGGGNMKDNWRSELYKYKVVRIEPL
GIAPTRAKRRVVQREKRAAGLGVMFLGFLGAAGSTMGAASIALTVQARQLLSGIVQQQNNLLRAIEAQQH
MLQLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTTVPWNASWSNKSHDQIWQNMTWMQWEKE
IDNYTSLIYNLIEVSQNQQEKNEQELLELDKWASLWNWFDITNWLWYIKIFIMIVGGLIGLRIVFIVLSI
VNRVRQGYSPLSFQTHLPARRGPDRPEGIEEEGGERDRDRSGQLVTGFLAIIWVDLRSLCLFSYHRLRDL
LLIVARIVELLGRRGWEILKYWWNLLQYWSQELKSGAVSLLNATAIAVAEGTDRVIEVLQRAGRAILHIP
RRIRQGFERALL
Protective antigen
env
Human immunodeficiency virus 1 strain Ba-L subtype B
326367
326371
CDD:278917
CDD:295533
CDD:197369
11676
?
8.87
91185.73
918
Envelope glycoprotein GP120; pfam00516
>AAA44191.1 env [Human immunodeficiency virus 1]
MRVTEIRKSYQHWWRWGIMLLGILMICNAEEKLWVTVYYGVPVWKEATTTLFCASDRKAYDTEVHNVWAT
HACVPTDPNPQEVELKNVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDLRNATNGN
DTNTTSSSRGMVGGGEMKNCSFNITTNIRGKVQKEYALFYKLDIAPIDNNSNNRYRLISCNTSVITQACP
KVSFEPIPIHYCAPAGFAILKCKDKKFNGKGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSAN
FADNAKVIIVQLNESVEINCTRPNNNTRKSIHIGPGRAFYTTGEIIGDIRQAHCNLSRAKWNDTLNKIVI
KLREQFGNKTIVFKHSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWNVTEESNNTVENNTITLPCRIKQ
IINMWQEVGRAMYAPPIRGQIRCSSNITGLLLTRDGGPEDNKTEVFRPGGGDMRDNWRSELYKYKVVKIE
PLGVAPTKAKRRVVQREKRAVGIGAVFLGFLGAAGSTMGAAAMTLTVQARLLLSGIVQQQNNLLRAIEAQ
QHLLQLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTAVPWNASWSNKSLNKIWDNMTWIEWD
REINNYTSIIYSLIEESQNQQEKNEQELLELDKWASLWNWFDITKWLWYIKIFIMIVGGLIGLRIVFSVL
SIVNRVRQGYSPLSFQTHLPSSRGPDRPGGIEEEGGERDRDRSGPLVNGFLALIWVDLRSLFLFSYHRLR
DLLLIVMRIVELLGLAGGWEVLKYWWNLLQYWSQELKNSAVSLLNATAVAVAEGTDRVIEVLQRAVRAIL
HIPRRIRQGLERALL
Protective antigen
env
Human immunodeficiency virus 1 strain 96ZM651
13569225
CDD:278917
CDD:197369
11676
?
envelope glycoprotein
8.71
93508.85
949
isolated in 1996
>AAK30970.1 envelope glycoprotein [Human immunodeficiency virus 1]
MRVREILRNWQRWWTWGILGFWMLMICNVWGNLWVTVYYGVPVWKEAKTTLFCASDAKSYEKEVHNVWAT
HACVPTDPNPQEIVLGNVTENFNMWKNDMVDQMHEDIISLWDQSLKPCVKLTPLCVTLNCTEVNVTRNVN
NSVVNNTTNVNNSMNGDMKNCSFNITTELKDKKKNVYALFYKLDIVSLNETDDSETGNSSKYYRLINCNT
SALTQACPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCHNVSTVQCTHGIKPVVSTQLLLNGSLAEE
GIIIRSENLTNNVKTIIVHLNRSIEIVCVRPNNNTRQSIRIGPGQTFYATGDIIGDIRQAHCNISRTNWT
KTLREVRNKLREHFPNKNITFKPSSGGDLEITTHSFNCRGEFFYCNTSGLFSINYTENNTDGTPITLPCR
IRQIINMWQEVGRAMYAPPIEGNIACKSDITGLLLVRDGGSTNDSTNNNTEIFRPAGGDMRDNWRSELYK
YKVVEIKPLGIAPTEAKRRVVEREKRAVGIGAVFLGFLGAAGSTMGAASITLTAQARQVLSGIVQQQSNL
LRAIEAQQHLLQLTVWGIKQLQTRVLAIERYLKDQQLLGLWGCSGKLICTTAVPWNISWSNKSKTDIWDN
MTWMQWDREISNYTNTIYRLLEDSQSQQEQNEKDLLALDSWNNLWNWFDITKWLWYIKIFIMIVGGLIGL
RIIFAVLSIVNRVRQGYSPLSFQTLIPNPREPDRPGRIEEEGGEQDKERSVRLVSGFLALAWDDLRSLCL
FSYHRLRDFILVTARAVELLRRSSLKGLQRGWEALKYLGSLVQYWGLELKKSAISLLDTIAIAVAEGTDR
IIELIQGICRAIRNVPRRIRQGFETALL
Protective antigen
env
Human immunodeficiency virus 1 strain 976 clone 17
475668
CDD:278917
CDD:295533
CDD:197369
11676
?
envelope glycoprotein
8.59
92331.19
944
Envelope glycoprotein GP120; pfam00516
>AAB04093.1 envelope glycoprotein, partial [Human immunodeficiency virus 1]
VKETQMNWPNLWKWGTLILGLVIICSASDNLWVTVYYGVPVWKDADTTLFCASDAKAHETEVHNVWATHA
CVPTDPNPQEIHLENVTENFNMWKNKMVEQMQEDVISLWDQSLKPCVKLTPLCVTLTCTNATLNCTNLTN
GNKTTNVSNIIGNLTDEVRNCSFHMTTELRDKKQKVYALFYKLDIVQINSSEYRLINCNTSVIKQACPKI
SFDPIPIHYCTPAGYAILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIISSENLT
NNAKTIIVHLNKSVEISCTRPSTNTRTSIRIGPGQVFYRTGDITGDIRKAYCEINETKWNEALKQVAGKL
KEHFNKTIIFQPPSGGDLEITMHHFNCRGEFFYCDTTQLFNRTWGENETREGRNITLPCKIKQIVNMWQG
AGQAMYAPPISGIIKCVSNITGILLTRDGGANNSASETFRPGGGNIKDNWRSELYKYKVVQIEPLGIAPT
RAKRRVVEREKRAVGIGAMIFGFLGAAGSTMGAASITLTVQARQLLSGIVQQQSNLLRAIEAQQHLLQLT
VWGIKQLQARVLAVERYLKDQKFLGLWGCSGKIICTTAVPWNSTWSNKSYEEIWNNMTWIEWEREISNYT
NQIYEILTESQDQQDRNEKDLLELDKWASLWNWFDITNWLWYIKIFIMIVGGLIGLRIIFAVLSIVNRVR
QGYSPLSFQIPFHHQREPDRPERIEEGGGEQGRDRSVRLVSGFLALAWDDLRSLCLFLYHRLRDLLLIAT
RTVEILGHSSLKGLRRGWEGLKYLGNLLIYWGQELRISAISLLNATAIAVGGWTDRIIEVAQRAWRAILR
IPRRIRQGLERSLL
Protective antigen
env
Human immunodeficiency virus 1 isolate 037 clone 08
487257
CDD:278917
CDD:295533
CDD:197369
11676
?
envelope glycoprotein
8.4
91749
946
Envelope glycoprotein GP120; pfam00516
>AAB05027.1 envelope glycoprotein, partial [Human immunodeficiency virus 1]
VMGIERNYPCWWTWGIMILGMIIICNTAENLWVTVYYGVPVWKDAETTLFCASDAKAYDTEVHNVWATHA
CVPTDPNPQEIYMENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVQLTPLCVTLDCSYNITNNITNSI
TNSSVNMREEIKNCSFNMTTELRDKNRKVYSLFYKLDVVQINNGNNSSNLYRLINCNTSALTQACPKVTF
EPIPIRYCAPAGYAILKCNDKEFNGTGLCKNVSTVQCTHGIRPVVSTQLLLNGSLAEGKVMIRSENITNN
VKNIIVQLNETVTINCTRPNNNTRKSVRIGPGQTFYATGDIIGDIRQAHCNVSGSQWNRALHQVVGQLRE
YWNTTIIFKNSSGGDLEITTHSFNCGGEFFYCNTSGLFNSNWTHNDTASMKPNDTITLPCRIKQIINMWQ
RVGQAIYAPPIQGVIRCESNITGLILTRDGGGNINESQIFRPGGGDMRDNWRSELYKYKVVRIEPLGVAP
TKAKRRVVEREKRAVVELGAVFIGFLGTAGSTMGAASITLTVQVRKLLSGIVQQQSNLLRAIEAQQHLLK
LTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTNVPWNSSWSNKSEREIWENMTWLQWDKEISN
YTHIIYELIEESQKQQEKNEQELLELDKWANLWNWFDISNWLWYIKIFIMIVGGLIGLRIVFAVLSVINR
VRQGYSPLSFQTLTPNPRDPDRPGRIEGEGGEQDRGRSIRLVSGFLALAWDDLRNLCLSSYHQLRDFILI
VARTVELLGHSSLKGLRLGWEGLKYLGNLLLYWGRELKTSAINLFDTIAIVVAGWTDRVIEVGQRLGRAI
LNIPRRIRQGLERALL
Protective antigen
env from SIV
Simian immunodeficiency virus
1490007
9627208
SIVgp6
M58410
NP_054372
11723
6201
8765
?
envelope protein
8.73
91594.7
854
>NC_001549.1:6201-8765 Simian immunodeficiency virus, complete genome
TATGGGGAGATTGCTTATAAAAATACTAATAATAGCAATAGGGATAAGTATAGGAATAGGTAACCTGTAT
GTGACAGTGTTTTATGGAATCCCAGTATGGAAAAATTCAACAGTTCAGGCATTTTGCATGACGCCCAATA
CCAATATGTGGGCAACCACCAACTGCATACCAGATGATCATGATAATACAGAGGTGCCTCTAAACATTAC
AGAAGCTTTCGAGGCTTGGGATAATCCGCTGGTAAAACAAGCAGAGAGTAATATACATCTACTCTTTGAA
CAAACGATGAGGCCTTGTGTTAAGCTCTCCCCCATATGTATTAAAATGTCCTGTGTAGAGCTGAATGGTA
CAGCCACGACAAAGGCCACCACTACTGCAACTACAACAATGACTACCCCCTGTCAGAATTGCAGTACAGA
GCAGATAGAAGGAGAAATGGCAGAGGAACCAGCATCCAACTGCACTTTTGCAATTGCAGGATATCAAAGA
GATGTAAAAAAGAATTATAGCATGACCTGGTATGATCAGGAGTTAGTCTGCAATAATAAAACAGGAAGTG
AAAAGGGAAGTAAGGATTGTTACATGATACATTGTAATGATTCAGTGATAAAAGAAGCTTGTGATAAAAC
ATATTGGGATACTTTAAGAGTAAGATACTGTGCACCAGCAGGGTATGCTTTGCTAAAATGTAATGATAAG
GATTATAGAGGCTTTGCTCCAAAGTGCAAGAATGTTTCAGTAGTGCATTGTACTAGATTAATCAATACTA
CTATAACTACAGGGATAGGATTAAATGGTAGTAGATCAGAAAATAGAACAGAGATATGGCAGAAAGGAGG
AAATGATAATGATACAGTTATAATAAAGTTGAATAAGTTTTACAACTTGACAGTGAGATGCCGAAGACCT
GGTAATAAAACAGTGTTGCCAGTAACAATCATGGCAGGGTTAGTATTTCACTCTCAGAAATATAATACCA
GGTTAAAACAAGCGTGGTGCCACTTCCAAGGAGATTGGAAAGGGGCATGGAAAGAAGTCAGAGAAGAAGT
AAAGAAAGTGAAAAATCTTACAGAAGTAAGCATAGAAAATATACATCTGAGAAGGATATGGGGAGATCCA
GAATCAGCGAATTTTTGGTTCAATTGTCAAGGTGAATTTTTCTATTGTAAGATGGACTGGTTTATCAATT
ATCTAAACAATCGAACAGAAGATGCAGAAGGTACTAATAGGACCTGTGACAAAGGGAAGCCAGGACCAGG
ACCATGTGTTCAGAGAACTTATGTTGCCTGCCATATACGACAAGTAGTAAATGATTGGTACACTGTCTCT
AAAAAGGTATATGCTCCACCAAGGGAAGGTCATTTGGAGTGTAACTCATCAGTCACGGCACTATACGTGG
CAATAGATTATAACAACAAGTCTGGCCCAATAAATGTGACCCTAAGTCCTCAGGTACGCAGCATATGGGC
GTACGAACTGGGAGACTATAAATTAGTAGAGATAACACCAATTGGCTTTGCTCCTACAGATGTAAGAAGA
TATACTGGCCCCACAAGAGAAAAAAGGGTGCCATTCGTGCTAGGGTTTCTAGGCTTCTTGGGAGCTGCTG
GAACTGCAATGGGCGCAGCGGCAACAACGCTGACAGTCCAGTCTCGGCATTTGCTTGCTGGGATATTGCA
GCAGCAGAAGAACTTGCTGGCGGCTGTGGAACAGCAACAACAGTTGTTGAAGCTGACCATTTGGGGTGTG
AAAAACCTCAATGCCCGCGTCACAGCTCTCGAGAAGTACCTAGAGGATCAGGCACGGCTAAATTCATGGG
GATGTGCGTGGAAACAAGTATGTCACACCACAGTGCCATGGAAGTATAATAACACTCCTAAGTGGGACAA
TATGACTTGGTTGGAGTGGGAGAGACAAATTAATGCCTTGGAAGGCAACATAACTCAACTATTGGAAGAA
GCACAAAATCAGGAATCAAAGAATCTGGATCTGTACCAGAAATTGGATGATTGGTCAGGGTTCTGGTCAT
GGTTCTCACTGTCAACTTGGTTAGGCTATGTTAAAATAGGATTTTTAGTGATAGTGATTATTCTAGGATT
AAGATTTGCATGGGTATTATGGGGATGTATCAGAAATATTAGGCAGGGATATAATCCTCTCCCCCAGATC
CATATCCACAGTTCAGCGGAACGGCCAGACAACGGAGGAGGGCAAGACAGAGGTGGAGAAAGCAGCAGCA
GCAAATTGATAAGATTGCAGGAAGAGTCCTCAACACCTTCGAGGATCAACAACTGGTGGCTCAACTTCAA
GAGCTGCAGCTTGAGAATAAGGACTTGGTGTTACAACATCTGCCTGACCCTCCTCATATTCATCAGGACA
GCAGTGGGATACCTGCAGTATGGGCTCCAGCAACTCCAAGAGGCAGCAACAGGGCTTGCTCAAGCTCTGG
CGAGGGCTGCGAGGGAAGCCTGGGGCAGACTGGGTGCTATTGTCCGATCCGCTTATCGGGCAGTCATCAA
CAGTCCAAGAAGAGTGCGGCAAGGCCTTGAAAAAGTCCTGGGGTA
>NP_054372.1 envelope protein [Simian immunodeficiency virus]
MGRLLIKILIIAIGISIGIGNLYVTVFYGIPVWKNSTVQAFCMTPNTNMWATTNCIPDDHDNTEVPLNIT
EAFEAWDNPLVKQAESNIHLLFEQTMRPCVKLSPICIKMSCVELNGTATTKATTTATTTMTTPCQNCSTE
QIEGEMAEEPASNCTFAIAGYQRDVKKNYSMTWYDQELVCNNKTGSEKGSKDCYMIHCNDSVIKEACDKT
YWDTLRVRYCAPAGYALLKCNDKDYRGFAPKCKNVSVVHCTRLINTTITTGIGLNGSRSENRTEIWQKGG
NDNDTVIIKLNKFYNLTVRCRRPGNKTVLPVTIMAGLVFHSQKYNTRLKQAWCHFQGDWKGAWKEVREEV
KKVKNLTEVSIENIHLRRIWGDPESANFWFNCQGEFFYCKMDWFINYLNNRTEDAEGTNRTCDKGKPGPG
PCVQRTYVACHIRQVVNDWYTVSKKVYAPPREGHLECNSSVTALYVAIDYNNKSGPINVTLSPQVRSIWA
YELGDYKLVEITPIGFAPTDVRRYTGPTREKRVPFVLGFLGFLGAAGTAMGAAATTLTVQSRHLLAGILQ
QQKNLLAAVEQQQQLLKLTIWGVKNLNARVTALEKYLEDQARLNSWGCAWKQVCHTTVPWKYNNTPKWDN
MTWLEWERQINALEGNITQLLEEAQNQESKNLDLYQKLDDWSGFWSWFSLSTWLGYVKIGFLVIVIILGL
RFAWVLWGCIRNIRQGYNPLPQIHIHSSAERPDNGGGQDRGGESSSSKLIRLQEESSTPSRINNWWLNFK
SCSLRIRTWCYNICLTLLIFIRTAVGYLQYGLQQLQEAATGLAQALARAAREAWGRLGAIVRSAYRAVIN
SPRRVRQGLEKVLG
Protective antigen
gag
Simian-Human immunodeficiency virus strain SHIV-89.6
2828037
CDD:249943
CDD:279002
CDD:331526
57667
?
gag
9.12
54236.02
573
gag gene protein p17 (matrix protein); pfam00540
>AAB99958.1 gag [Simian-Human immunodeficiency virus]
MGVRNSVLSGKKADELEKIRLRPNGKKKYMLKHVVWAANELDRFGLAESLLENKEGCQKILSVLAPLVPT
GSENLKSLYNTVCVIWCIHAEEKVKHTEEAKQIVQRHLVVETGTTETMPKTSRPTAPSSGRGGNYPVQQI
GGNYVHLPLSPRTLNAWVKLIEEKKFGAEVVPGFQALSEGCTPYDINQMLNCVGDHQAAMQIIRDIINEE
AADWDLQHPQPAPQQGQLREPSGSDIAGTTSSVDEQIQWMYRQQNPIPVGNIYRRWIQLGLQKCVRMYNP
TNILDVKQGPKEPFQSYVDRFYKSLRAEQTDAAVKNWMTQTLLIQNANPDCKLVLKGLGVNPTLEEMLTA
CQGVGGPGQKARLMAEALKEALAPVPIPFAAAQQRGPRKPIKCWNCGKEGHSARQCRAPRRQGCWKCGKM
DHVMAKCPDRQAGFLGLGPWGKKPRNFPMAQVHQGLMPTAPPEDPAVDLLKNYMQLGKQQREKQRESREK
PYKEVTEDLLHLNSLFGGDQ
Protective antigen
gag
Human immunodeficiency virus 2
1845205
CDD:249943
CDD:279002
CDD:197667
11709
?
gag polyprotein
9.25
55390.11
591
similar to HIV2BEN, GenBank Accession Number M30502, and to HIV2D194, GenBank Accession Number J04542
>AAB47780.1 gag polyprotein [Human immunodeficiency virus 2]
MGARNSVLRGKKADELEKIRLRPGGKKKYRLKHIVWAANELDRFRLAENLLESKEGCQKILTVLDPLVPT
GSENLKSLFNTVCVIWCLHAEEKVKDTEEAKKLVQRHLVAETGTAEKMPNTSRPTAPPSGKGGNFPVQQA
GGNYVHVPLSPRTLNAWVKLVEEKKFGAEVVPGFQALSEGCTPYDINQMLNCVGDQQAAMQIIREIINEE
AADWDAQHPIPGPLPAGQLRDPRGSDIAGTTSTVDEQIQWMYRQQNPVPVGNIYRRWIQIGLQKCVRMYN
PTNVLDVKQGPKESFQSYVDRFYKSLRAEQADPAVKNWMTQTLLVQNANPDCKLVLKGLGMNPTLEEMLT
ACQGVGGPGQKARLMAEALKEALTPPPIPFAAAQQRRTIRCWNCGKEGHSAKQCRAPRRQGCWKCGKPGH
IMANCPDRQAGFLGMGSRGKKPRNFPVAQAPQGLIPTAPPADPAADLLEKYLQQGRKQREQRERPYKEVT
EDLLHLEQGETPRREATEDLLHLNSLFGKDQ
Protective antigen
Gag from HIV 1
Human immunodeficiency virus 1
VO_0011263
155030
9629360
HIV1gp2
AF033819
NP_057850
11676
335
1837
+
Pr55(Gag)
9.42
53447.94
500
>NC_001802.1:335-1837 Human immunodeficiency virus 1, complete genome
GATGGGTGCGAGAGCGTCAGTATTAAGCGGGGGAGAATTAGATCGATGGGAAAAAATTCGGTTAAGGCCA
GGGGGAAAGAAAAAATATAAATTAAAACATATAGTATGGGCAAGCAGGGAGCTAGAACGATTCGCAGTTA
ATCCTGGCCTGTTAGAAACATCAGAAGGCTGTAGACAAATACTGGGACAGCTACAACCATCCCTTCAGAC
AGGATCAGAAGAACTTAGATCATTATATAATACAGTAGCAACCCTCTATTGTGTGCATCAAAGGATAGAG
ATAAAAGACACCAAGGAAGCTTTAGACAAGATAGAGGAAGAGCAAAACAAAAGTAAGAAAAAAGCACAGC
AAGCAGCAGCTGACACAGGACACAGCAATCAGGTCAGCCAAAATTACCCTATAGTGCAGAACATCCAGGG
GCAAATGGTACATCAGGCCATATCACCTAGAACTTTAAATGCATGGGTAAAAGTAGTAGAAGAGAAGGCT
TTCAGCCCAGAAGTGATACCCATGTTTTCAGCATTATCAGAAGGAGCCACCCCACAAGATTTAAACACCA
TGCTAAACACAGTGGGGGGACATCAAGCAGCCATGCAAATGTTAAAAGAGACCATCAATGAGGAAGCTGC
AGAATGGGATAGAGTGCATCCAGTGCATGCAGGGCCTATTGCACCAGGCCAGATGAGAGAACCAAGGGGA
AGTGACATAGCAGGAACTACTAGTACCCTTCAGGAACAAATAGGATGGATGACAAATAATCCACCTATCC
CAGTAGGAGAAATTTATAAAAGATGGATAATCCTGGGATTAAATAAAATAGTAAGAATGTATAGCCCTAC
CAGCATTCTGGACATAAGACAAGGACCAAAGGAACCCTTTAGAGACTATGTAGACCGGTTCTATAAAACT
CTAAGAGCCGAGCAAGCTTCACAGGAGGTAAAAAATTGGATGACAGAAACCTTGTTGGTCCAAAATGCGA
ACCCAGATTGTAAGACTATTTTAAAAGCATTGGGACCAGCGGCTACACTAGAAGAAATGATGACAGCATG
TCAGGGAGTAGGAGGACCCGGCCATAAGGCAAGAGTTTTGGCTGAAGCAATGAGCCAAGTAACAAATTCA
GCTACCATAATGATGCAGAGAGGCAATTTTAGGAACCAAAGAAAGATTGTTAAGTGTTTCAATTGTGGCA
AAGAAGGGCACACAGCCAGAAATTGCAGGGCCCCTAGGAAAAAGGGCTGTTGGAAATGTGGAAAGGAAGG
ACACCAAATGAAAGATTGTACTGAGAGACAGGCTAATTTTTTAGGGAAGATCTGGCCTTCCTACAAGGGA
AGGCCAGGGAATTTTCTTCAGAGCAGACCAGAGCCAACAGCCCCACCAGAAGAGAGCTTCAGGTCTGGGG
TAGAGACAACAACTCCCCCTCAGAAGCAGGAGCCGATAGACAAGGAACTGTATCCTTTAACTTCCCTCAG
GTCACTCTTTGGCAACGACCCCTCGTCACAATA
>NP_057850.1 Pr55(Gag) [Human immunodeficiency virus 1]
MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQT
GSEELRSLYNTVATLYCVHQRIEIKDTKEALDKIEEEQNKSKKKAQQAAADTGHSNQVSQNYPIVQNIQG
QMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAA
EWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPT
SILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTAC
QGVGGPGHKARVLAEAMSQVTNSATIMMQRGNFRNQRKIVKCFNCGKEGHTARNCRAPRKKGCWKCGKEG
HQMKDCTERQANFLGKIWPSYKGRPGNFLQSRPEPTAPPEESFRSGVETTTPPQKQEPIDKELYPLTSLR
SLFGNDPSSQ
Protective antigen
HIV-1 DNA plasmids expressing Env, Gag and Tat, either alone or combined with the corresponding protein immunogens formulated in the MF59 adjuvant, resulted in protection against an experimental HIV-1 infection in C57Bl/6 mice [Ref1301:Bråve et al., 2007].
gag from HIV-1 vector pNL4-3
HIV-1 vector pNL4-3
12831136
CDD:249943
CDD:279002
CDD:331526
CDD:312289
11676
?
gag polyprotein
9.31
54183.8
569
from sequence deposited in GenBank Accession Number M19921
>AAK08483.1 gag polyprotein (plasmid) [HIV-1 vector pNL4-3]
MGARASVLSGGELDKWEKIRLRPGGKKQYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQT
GSEELRSLYNTIAVLYCVHQRIDVKDTKEALDKIEEEQNKSKKKAQQAAADTGNNSQVSQNYPIVQNLQG
QMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAA
EWDRLHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPT
SILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPGATLEEMMTAC
QGVGGPGHKARVLAEAMSQVTNPATIMIQKGNFRNQRKTVKCFNCGKEGHIAKNCRAPRKKGCWKCGKEG
HQMKDCTERQANFLGKIWPSHKGRPGNFLQSRPEPTAPPEESFRFGEETTTPSQKQEPIDKELYPLASLR
SLFGSDPSSQ
Protective antigen
Gag protein from SIV-mnd 2
Simian immunodeficiency virus SIV-mnd 2
VO_0010949
956108
27311167
Siv2gp1
AF367411
NP_758886
159122
736
2289
+
gag protein
8.78
55072.29
517
>NC_004455.1:736-2289 Simian immunodeficiency virus 2 isolate SIVmnd-2, complete genome
AATGGGCGCGAGCGCGTCAGGTCTTAGGGGAGAAAAATTGGACGAGCTGGAAAAGATTAGGTTACGGCCC
TCCGGAAAAAAGAAATACCAGCTGAAACACATAATATGGGTAAGCAAGGAACTAGACAGATTTGGCCTTC
ATGAAAAGCTGTTAGAAAGTAAGGAAGGATGCGAGAAAATTCTTAGCGTACTCTTTCCACTAGTTCCTAC
AGGGTCAGAAAATTTAATCTCGCTGTACAACACCTGCTGCTGCGTATGGTGCGTACATGCGAAAGAGAAA
GTAACAGATACAGAGGAAGCGAAAGAGAAAGTAAAACAAAAGCTCCATCTAGTGGCCGAAAAGGAAAATG
CAGCATCAGAAAAAGAACAAAGAGCAATAGTGACACCTAGTGGCCGCTCAAAAAATTACCCAATACAGAT
AATAAATCAGACCCCAGTCCATCAGGGAATTTCACCGCGCACGCTGAATGCGTGGGTAAAATGCATAGAA
GAGAAGAAGTTTAGCCCAGAAATAGTGCCCATGTTCATAGCCTTGTCTGAAGGGTGCCTCCCCTATGATC
TCAATGGCATGCTCAATGCTATTGGAGACCATCAGGGAGCGCTTCAAATAGTGAAGGATGTCATCAATGA
GGAAGCTGCAGACTGGAACTTGAGACACCCACAAGTGGGTCCTATGCCCCAAGGTGTCTTGAGAAACCCA
ACGGGCAGTGATATTGCTGGAACAACAAGCTCCATAGAAGAGCAGATAGAATGGACTACAAGGGAGCAAG
ATGCAGTAAATGTGGGAGGAATATATAAACAATGGATAGTTTTAGGGCTTCAGAAGTGTGTAAGCATGTA
TAATCCAGTAAACATCCTGGACATAAAGCAAGGACCAAAGGAGCCGTTCAAGGACTATGTGGACAGGTTT
TACAAAGCTCTGCGGGCGGAGCGGACTGATCCACAAGTCAAAACCTGGATGACACAAACTTTGCTCATCC
AGAATGCTAACCCAGATTGTAAATCCATCCTTAAAGGGCTAGGCATGAATCCCTCTTTAGAAGAGATGCC
GCTAGCCTGCCAAGGGGTAGGAGGCCCTAAATATAAAGCACAAATGATGGCAGAGGCTATGAAGGAAGCC
CAGTCAGCTGTAATGATGCAGAATTCGGGAGGGCCACCGCGGGGCCCCCCGAGACAACCTCCTAGAAACA
TCAGATGCCCTAACTGTGGAAAATTTGGTCATGGGCTGAGGGACTGTATAAGCCCTCGAAAAAAGGGATG
CTTCAAGTGTGGAGATCTAGGACACATAATGAGAAATTGCCCAAAGATGGTGAATTTTTTAGGGAATACC
CCCTGGGGCAGTGGCAAACCCAGGAACTTCCCGGCGATGCCATTGACCCCAACGGCCCCTCCAATGCCAG
GGATGGAAGACCCAGCAGAGAGAATGCTGTTAGATTACATGAAGAAAGGGCAACAGCAGAAAGCGGAAAG
CAAACAGGAAAAGAAAGAGAGGGGTCCATACGAGGCAGCTTACAACTCCCTCAGTTCTCTCTTTGGAACA
GACCAACTACAGTA
>NP_758886.1 gag protein [Simian immunodeficiency virus SIV-mnd 2]
MGASASGLRGEKLDELEKIRLRPSGKKKYQLKHIIWVSKELDRFGLHEKLLESKEGCEKILSVLFPLVPT
GSENLISLYNTCCCVWCVHAKEKVTDTEEAKEKVKQKLHLVAEKENAASEKEQRAIVTPSGRSKNYPIQI
INQTPVHQGISPRTLNAWVKCIEEKKFSPEIVPMFIALSEGCLPYDLNGMLNAIGDHQGALQIVKDVINE
EAADWNLRHPQVGPMPQGVLRNPTGSDIAGTTSSIEEQIEWTTREQDAVNVGGIYKQWIVLGLQKCVSMY
NPVNILDIKQGPKEPFKDYVDRFYKALRAERTDPQVKTWMTQTLLIQNANPDCKSILKGLGMNPSLEEMP
LACQGVGGPKYKAQMMAEAMKEAQSAVMMQNSGGPPRGPPRQPPRNIRCPNCGKFGHGLRDCISPRKKGC
FKCGDLGHIMRNCPKMVNFLGNTPWGSGKPRNFPAMPLTPTAPPMPGMEDPAERMLLDYMKKGQQQKAES
KQEKKERGPYEAAYNSLSSLFGTDQLQ
Protective antigen
A novel primate lentivirus was identified in Mandrillus sphinx. One of the newly isolated SIV strains was intravenously inoculated into two rhesus macaques and resulted in chronic infection. These SIVs do not cluster with SIVmndGB1, the former representative strain of SIVmnd, but form a new, independent lineage. These results indicate that these SIVmnds are a novel type of SIVmnd and have infected Cameroonian mandrills for a long time. To date, M. sphinx is the only primate species other than humans that is naturally infected with two different types of SIV [Ref265:Takehisa et al., 2001].
gag-pol
Human immunodeficiency virus 1
155348
28872819
HIV1gp1
AF033819
NP_057849
11676
335
4641
+
Gag-Pol
9.02
152515.27
1435
Pr160
>NC_001802.1:335-4641 Human immunodeficiency virus 1, complete genome
GATGGGTGCGAGAGCGTCAGTATTAAGCGGGGGAGAATTAGATCGATGGGAAAAAATTCGGTTAAGGCCA
GGGGGAAAGAAAAAATATAAATTAAAACATATAGTATGGGCAAGCAGGGAGCTAGAACGATTCGCAGTTA
ATCCTGGCCTGTTAGAAACATCAGAAGGCTGTAGACAAATACTGGGACAGCTACAACCATCCCTTCAGAC
AGGATCAGAAGAACTTAGATCATTATATAATACAGTAGCAACCCTCTATTGTGTGCATCAAAGGATAGAG
ATAAAAGACACCAAGGAAGCTTTAGACAAGATAGAGGAAGAGCAAAACAAAAGTAAGAAAAAAGCACAGC
AAGCAGCAGCTGACACAGGACACAGCAATCAGGTCAGCCAAAATTACCCTATAGTGCAGAACATCCAGGG
GCAAATGGTACATCAGGCCATATCACCTAGAACTTTAAATGCATGGGTAAAAGTAGTAGAAGAGAAGGCT
TTCAGCCCAGAAGTGATACCCATGTTTTCAGCATTATCAGAAGGAGCCACCCCACAAGATTTAAACACCA
TGCTAAACACAGTGGGGGGACATCAAGCAGCCATGCAAATGTTAAAAGAGACCATCAATGAGGAAGCTGC
AGAATGGGATAGAGTGCATCCAGTGCATGCAGGGCCTATTGCACCAGGCCAGATGAGAGAACCAAGGGGA
AGTGACATAGCAGGAACTACTAGTACCCTTCAGGAACAAATAGGATGGATGACAAATAATCCACCTATCC
CAGTAGGAGAAATTTATAAAAGATGGATAATCCTGGGATTAAATAAAATAGTAAGAATGTATAGCCCTAC
CAGCATTCTGGACATAAGACAAGGACCAAAGGAACCCTTTAGAGACTATGTAGACCGGTTCTATAAAACT
CTAAGAGCCGAGCAAGCTTCACAGGAGGTAAAAAATTGGATGACAGAAACCTTGTTGGTCCAAAATGCGA
ACCCAGATTGTAAGACTATTTTAAAAGCATTGGGACCAGCGGCTACACTAGAAGAAATGATGACAGCATG
TCAGGGAGTAGGAGGACCCGGCCATAAGGCAAGAGTTTTGGCTGAAGCAATGAGCCAAGTAACAAATTCA
GCTACCATAATGATGCAGAGAGGCAATTTTAGGAACCAAAGAAAGATTGTTAAGTGTTTCAATTGTGGCA
AAGAAGGGCACACAGCCAGAAATTGCAGGGCCCCTAGGAAAAAGGGCTGTTGGAAATGTGGAAAGGAAGG
ACACCAAATGAAAGATTGTACTGAGAGACAGGCTAATTTTTTAGGGAAGATCTGGCCTTCCTACAAGGGA
AGGCCAGGGAATTTTCTTCAGAGCAGACCAGAGCCAACAGCCCCACCAGAAGAGAGCTTCAGGTCTGGGG
TAGAGACAACAACTCCCCCTCAGAAGCAGGAGCCGATAGACAAGGAACTGTATCCTTTAACTTCCCTCAG
GTCACTCTTTGGCAACGACCCCTCGTCACAATAAAGATAGGGGGGCAACTAAAGGAAGCTCTATTAGATA
CAGGAGCAGATGATACAGTATTAGAAGAAATGAGTTTGCCAGGAAGATGGAAACCAAAAATGATAGGGGG
AATTGGAGGTTTTATCAAAGTAAGACAGTATGATCAGATACTCATAGAAATCTGTGGACATAAAGCTATA
GGTACAGTATTAGTAGGACCTACACCTGTCAACATAATTGGAAGAAATCTGTTGACTCAGATTGGTTGCA
CTTTAAATTTTCCCATTAGCCCTATTGAGACTGTACCAGTAAAATTAAAGCCAGGAATGGATGGCCCAAA
AGTTAAACAATGGCCATTGACAGAAGAAAAAATAAAAGCATTAGTAGAAATTTGTACAGAGATGGAAAAG
GAAGGGAAAATTTCAAAAATTGGGCCTGAAAATCCATACAATACTCCAGTATTTGCCATAAAGAAAAAAG
ACAGTACTAAATGGAGAAAATTAGTAGATTTCAGAGAACTTAATAAGAGAACTCAAGACTTCTGGGAAGT
TCAATTAGGAATACCACATCCCGCAGGGTTAAAAAAGAAAAAATCAGTAACAGTACTGGATGTGGGTGAT
GCATATTTTTCAGTTCCCTTAGATGAAGACTTCAGGAAGTATACTGCATTTACCATACCTAGTATAAACA
ATGAGACACCAGGGATTAGATATCAGTACAATGTGCTTCCACAGGGATGGAAAGGATCACCAGCAATATT
CCAAAGTAGCATGACAAAAATCTTAGAGCCTTTTAGAAAACAAAATCCAGACATAGTTATCTATCAATAC
ATGGATGATTTGTATGTAGGATCTGACTTAGAAATAGGGCAGCATAGAACAAAAATAGAGGAGCTGAGAC
AACATCTGTTGAGGTGGGGACTTACCACACCAGACAAAAAACATCAGAAAGAACCTCCATTCCTTTGGAT
GGGTTATGAACTCCATCCTGATAAATGGACAGTACAGCCTATAGTGCTGCCAGAAAAAGACAGCTGGACT
GTCAATGACATACAGAAGTTAGTGGGGAAATTGAATTGGGCAAGTCAGATTTACCCAGGGATTAAAGTAA
GGCAATTATGTAAACTCCTTAGAGGAACCAAAGCACTAACAGAAGTAATACCACTAACAGAAGAAGCAGA
GCTAGAACTGGCAGAAAACAGAGAGATTCTAAAAGAACCAGTACATGGAGTGTATTATGACCCATCAAAA
GACTTAATAGCAGAAATACAGAAGCAGGGGCAAGGCCAATGGACATATCAAATTTATCAAGAGCCATTTA
AAAATCTGAAAACAGGAAAATATGCAAGAATGAGGGGTGCCCACACTAATGATGTAAAACAATTAACAGA
GGCAGTGCAAAAAATAACCACAGAAAGCATAGTAATATGGGGAAAGACTCCTAAATTTAAACTGCCCATA
CAAAAGGAAACATGGGAAACATGGTGGACAGAGTATTGGCAAGCCACCTGGATTCCTGAGTGGGAGTTTG
TTAATACCCCTCCCTTAGTGAAATTATGGTACCAGTTAGAGAAAGAACCCATAGTAGGAGCAGAAACCTT
CTATGTAGATGGGGCAGCTAACAGGGAGACTAAATTAGGAAAAGCAGGATATGTTACTAATAGAGGAAGA
CAAAAAGTTGTCACCCTAACTGACACAACAAATCAGAAGACTGAGTTACAAGCAATTTATCTAGCTTTGC
AGGATTCGGGATTAGAAGTAAACATAGTAACAGACTCACAATATGCATTAGGAATCATTCAAGCACAACC
AGATCAAAGTGAATCAGAGTTAGTCAATCAAATAATAGAGCAGTTAATAAAAAAGGAAAAGGTCTATCTG
GCATGGGTACCAGCACACAAAGGAATTGGAGGAAATGAACAAGTAGATAAATTAGTCAGTGCTGGAATCA
GGAAAGTACTATTTTTAGATGGAATAGATAAGGCCCAAGATGAACATGAGAAATATCACAGTAATTGGAG
AGCAATGGCTAGTGATTTTAACCTGCCACCTGTAGTAGCAAAAGAAATAGTAGCCAGCTGTGATAAATGT
CAGCTAAAAGGAGAAGCCATGCATGGACAAGTAGACTGTAGTCCAGGAATATGGCAACTAGATTGTACAC
ATTTAGAAGGAAAAGTTATCCTGGTAGCAGTTCATGTAGCCAGTGGATATATAGAAGCAGAAGTTATTCC
AGCAGAAACAGGGCAGGAAACAGCATATTTTCTTTTAAAATTAGCAGGAAGATGGCCAGTAAAAACAATA
CATACTGACAATGGCAGCAATTTCACCGGTGCTACGGTTAGGGCCGCCTGTTGGTGGGCGGGAATCAAGC
AGGAATTTGGAATTCCCTACAATCCCCAAAGTCAAGGAGTAGTAGAATCTATGAATAAAGAATTAAAGAA
AATTATAGGACAGGTAAGAGATCAGGCTGAACATCTTAAGACAGCAGTACAAATGGCAGTATTCATCCAC
AATTTTAAAAGAAAAGGGGGGATTGGGGGGTACAGTGCAGGGGAAAGAATAGTAGACATAATAGCAACAG
ACATACAAACTAAAGAATTACAAAAACAAATTACAAAAATTCAAAATTTTCGGGTTTATTACAGGGACAG
CAGAAATCCACTTTGGAAAGGACCAGCAAAGCTCCTCTGGAAAGGTGAAGGGGCAGTAGTAATACAAGAT
AATAGTGACATAAAAGTAGTGCCAAGAAGAAAAGCAAAGATCATTAGGGATTATGGAAAACAGATGGCAG
GTGATGATTGTGTGGCAAGTAGACAGGATGAGGATTA
>NP_057849.4 Gag-Pol [Human immunodeficiency virus 1]
MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQT
GSEELRSLYNTVATLYCVHQRIEIKDTKEALDKIEEEQNKSKKKAQQAAADTGHSNQVSQNYPIVQNIQG
QMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAA
EWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPT
SILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTAC
QGVGGPGHKARVLAEAMSQVTNSATIMMQRGNFRNQRKIVKCFNCGKEGHTARNCRAPRKKGCWKCGKEG
HQMKDCTERQANFLREDLAFLQGKAREFSSEQTRANSPTRRELQVWGRDNNSPSEAGADRQGTVSFNFPQ
VTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAI
GTVLVGPTPVNIIGRNLLTQIGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEK
EGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGD
AYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQY
MDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWT
VNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSK
DLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPI
QKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGR
QKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYL
AWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKC
QLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTI
HTDNGSNFTGATVRAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIH
NFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNPLWKGPAKLLWKGEGAVVIQD
NSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
Protective antigen
gp120
Human immunodeficiency virus 1
2326505
CDD:278917
GOA:O40515
InterPro:IPR000777
UniProtKB/TrEMBL:O40515
11676
?
9.81
11668
172
Envelope glycoprotein GP120; pfam00516
>CAA74764.1 gp120, partial [Human immunodeficiency virus 1]
NGSLAEGEVVIRSENFTDNAKTIIVQLNESVVINCTRPNNNTRKNIHLGRGRSVYATEKIIGNVKQAHCN
ISRAKWNDTLKQIVEKLREQFGKNKTIVFNQSSGGDPEI
Protective antigen
IFNG
Macaca mulatta
574282
74136365
EGK_03901
CM001263
NP_001028077
9544
11
65143979
65148219
-
interferon-gamma
9.92
18339.63
165
Also known as IFN-gamma
>gi|109156580:65143979-65148219 Macaca mulatta chromosome 11, Mmul_051212, whole genome shotgun sequence
ATTATTGGGATGCTCTTCGACCTCGAAACATCTGACTCCTTTTTCGCTTCCCTATTTTAGCTGCTGGCGA
CAGTTCAGCCATCACTTGGATGAGTTCATGTACTGCTTTGCGTTGGACATTTGAGTCAGTTACCTATTGG
GAAAGAAAAGAGCAAAATTAATTTCAGGCATATAAGCCATCAGGATATTCAGTTAATGGCATGATGGTCA
GTGAAAATAAAACTATTCCTTTAAAAAAATGGACCATATTACCTTAATATACAATATTTACTTCTTCAGC
AGTTGAGGCTAAAAATTACAATTACATTACTAGTTGTGCAATGATGTGGTGGAGTCCGTCACATATCTTT
AAATCTACTCCCATAGAATTCTTGAAATCATATAGTGAAAAGACCCCTGGTGTGGAGTCAATGTAAAAAG
GTGGATCTGAATCTCATGCGTGCAATAATTCTGACCTTGAGCCAGCTACTTAACCTTTTGGAACCTCTAT
TTTCTCATCTAAAGGAAGAGAAGACTGTTTCTATGACCTCTCTATCATCAATCTACCAATTATATCACTT
TATACTTTAGTCTCTCCTGTATGTATCAAACGAGTAACTATAGGTCAATGATTCTCACTGTTGTGCATAG
CAGATTAACCTGGAAACCTAATAAAGACCTCAGAGATCCAGGGGCACGAATTGGAAGGACTGTGCCCTGT
GCATTCACTAAGCTCCCCAGGTGATTCTGACATCCACCTAAGTTTGAGAACCACTGATCTAGGTTAGGTA
CCCTAGAAAACATCAAATCCAAAACAAGTGAAAACTGTAATTTTTAATTTCTCCCAGATTAGATCAGTCT
CTCAATTTCCATAATAGGTTTTAAAATAACCACCAATCATATTTATATATGGCTTACTGATATATAAAGT
TTAAAATTAGGAATTGCAACAACTTTTTCAGTACCCTACCTTCTAGGCCAGCAAATTGAACTACTTGCAT
TTCCTCACTCTAACTAATAGGGCCATTTAGGTGATTTCATTCTTCCTAAAATGTGGACCATTTACTTTCC
TCTTGACTCTGCCATTATATTTTTTCTAATCTTGGGAACACTATGGCTACCTCGCCACATTTCTGAGGAT
GGCTGGGGGATTACAGGCTACAGAGCTAATTATGAAAGGGCATAACATACCTCAGCTTAGCAACTGAGCC
AAAGAGAACAATAATTAATAGAGCTCACTCAAGATTGCCCATCAAGAAACAGGAGGTTTGTAGCTTCCAG
AAGGAAGAAACCCACAGATTTTTTTTTCACTTTTTTAAGGCCCAGTTCCTGCGGAGTAGAAAAAGTTTTC
TACAAGCTGTGTGTTTGCAAGTGACAGATTTTACTTTCCAGTGTTCAAATCATCACCAAGAAACTAAGAG
ACTTATCCAGGACGGAACAGTAAGCCAGGGGCACCACTGGGTTGGTGGCAAGTGCTGAGTGTCTAGTTTC
TAACCAAAGGAGACCTGTTGCCATGTCCCTCCTTTCAGTTTCTGGGGGTTCACATGAGAGGAGTGAGAGG
CAGGCCCGGCAATAGTGAAAGCTGAGCACAAATCCTAAGAGCACAAATGCCAGCTTGAGCTCTCATTTGA
GCCCATTTATATCAAAGCCAATCCCAAAGGAATCTAGAGGTCTTTGTCTTCTAGATAAAATTTTGAAAAA
CGTGTTTTGTCTTTATGCCTCAATGTTATCTTTCTGTTTATAGAAGGCATAATTTAAAGATAATTTAAAG
ATACAAGTTCATGAGGTATGACTTAGGAGTCTAAGGAGTTCTCCAGCTGAGATATTCTGAAAGTTGATAG
AGACTTGATAGAACAATGTTTTCATAAGCTATAAATTCTACCTATTTTTCCCTAAAAACAAACAGCAACC
ATTCTTGCTTCTAATTAGGCAGTACAATCTGATAGGTTGGCTAGAGAATTGCAGTGGGGTGCACTGGTAC
CTACTCAAAGGCTGTAGCTTTCTTCTATCTCATTCTCATTTTCTATTCTTGGCATTGTAGAGTTTTGGAG
CAAAGAATGTCATCAAACTTATGCAGTGAACCTAACAGTTTCCTTTTAAGATGAGGGCACTGAGCCCCAG
CCAGCCATGTGATTCATCACAGTTCCCTGGTGGCTGAGATGGGAGGAGAACACACATCTTCTCAGCTCCT
CCCACTGCTCTTTCCATTAAGACAGACAGCCTCTCATTCAAAGTAAGAGAATTTCCATCATATGAGCAAA
GGACAATGAGAGAATTGCTTCTCAGTACTCCCCACTACTTCCTCACCTACTTCCTCTTCATTGGATTTGT
CAATTCACCTGTCTTTACACAATAGTTACAATGCCAGCACTTTTCCTACATTACATACTTCAGTGATTCC
CATACTGGCTTTGCAAAGTCATCCAAACACAAATAGAATTAGTAAGAGTTTCAGCTACGGGTTGAGTTCA
TAGCTTTAGCAACTGTTAAATAGCTAATGTCTACTTTCTGGAGAACAAATGCTTTGCAAGACCTTCCGCA
ATGAAACCAAAGAAAGAATTTAAAGAGCCTTACCGAATAATTGGTCAGCTTTTCAAAGTCATCCCGTTTC
TTTTTGTTGCTATTGAAAAACTTGACATTAATGTCTTCCTTGATGGTCTCCACACTCTTTTGGATCCTCT
GGTCATCTTTGAAGTTTTTAAAAAGTTTGAAGTAAAAGGAGACAATTTGGCTCTGCATTATTTTTCTGTC
ACTCTCCTTGGAAGGAAAGAACACAAACAGAGGATGATGTGTATTTATCCATCAGAAAGCAAGCAACAGG
AAAATTAGCCAAATGGGAATATTCAGCTTACCTCTTTCCAATTCCTCAAGATGTCTAAGAAAAGAGTTCC
ATTATCTGCTACATCTGGATCACCTGCATTCTGGGGGAAAAAAAAGGGTTTACAATTAGCCCATAAATTG
TCTTAAAAATATATTTCAAGTTTCATTAAACTCAGATGTGACAATATTCACTGATTTCCTTTTCAATTCT
TCTGCTTAGTTCTAACAATAAGTGTTCACAAAATGTTTATGTGAGATATAGCCAAAGACTACTATGCTCT
TTTAGCTTTTTTATTTTCCAACATAACCATTAAATTGCAATGTCACAAAGGAGTTAAACAAAGCTGATGA
TACTCCAAGGGTCTCAAAAACTATAGTAGGCTAAAGAAAGTATTTTCAAGCTAGGCTAAAAAATACAGAA
CAAAAAACAGCAAAGCCACCCCACTATAAAATACTGCCCCCCAATGGCACAGGTTTCTATTACATCTACT
ATGCCTTCCTGTAGGGTATTATGTCAACTTTAAAAGATAGTTCCAAACGTGTGCGTGCGTGTGTGTGTGT
GTGTGTGTGTGTGGTCTGATTTTGTGTTGTAGGAATAAAATTAATTGTGAATGTCTGAATATTAGTATGA
CAGCTATAATTATAACTAAGTTTTAAATAAATAATGAAATATTTAAAATGTAAAAACTTTTCATTAACCA
TCAATAAAATTTTAAAAGAAACTCAAAAAACTCACTTAAAATTTTTAAACATTCCATAGCCAGAATCATA
ATTCCTACAAAATCCCAGTGAGCAACTAAGTTCAGGAGTAATTCACAAGGAATATAGATAGAGCAGCAGA
ATGTTGAAATAACTTTTTGGAGAAAATCACCTATCAGTGATTTTTTTTAAGCCAAAACTTTAAGGACCTT
TTTTACTTTAATTTGTAAACGTTTCCTATTAACTTTTGAATGCTAATCTTGACCTTAGAGTCTGAGAAGT
CAAAAACTAATAGCCAATCATTTTTTTCAATATGCATACTCCTTGACTTATCACATCTGAATGAGTTCTC
ACCACAAAATTATTAACATCATTATGCTTCATATCCATATTATGCCCATCTTTGGGAAGATTCATAAATC
CCTTTTAAGTCTCTATACAAACTGAGCAGAAGGTTAAAACAATATCTAGATTATGTAGTCAAGAAACTCA
TCCAGTCAATAATTAACAAAATAAAACCAGATCTCAAAATGACTGCGTACGAGAGGACAGTCTATCAGAG
ATGCTACAGCAAGTCAATATTCAGACATTTTCAACCACAAAAAAGTACTATTAAAAAGCCATACTTACAA
AATATTTCTTAAGGTTTTCTGCTTCTTTTACATATGGGTCCTGGCAGTAACAGCCAAGAGAACCCAAAAC
AATGCAGAGCTGAAAAGCCAAGATATAACTTGTGTATTTCA
>gi|74136365|ref|NP_001028077.1| interferon gamma precursor [Macaca mulatta]
MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGDPDVADNGTLFLDILRNWKEESDRKIMQS
QIVSFYFKLFKNFKDDQRIQKSVETIKEDINVKFFNSNKKKRDDFEKLTNYSVTDSNVQRKAVHELIQVM
AELSPAAKIGKRKRSQMFRGRRASQ
Vaximmutor
Ifng (Interferon gamma)
Mouse
15978
33468859
NM_008337
NP_032363.1
MGI:107656; UniProt:P01580
10090
?
>gi|145966741|ref|NM_008337.3| Mus musculus interferon gamma (Ifng), mRNA
ATAGCTGCCATCGGCTGACCTAGAGAAGACACATCAGCTGATCCTTTGGACCCTCTGACTTGAGACAGAA
GTTCTGGGCTTCTCCTCCTGCGGCCTAGCTCTGAGACAATGAACGCTACACACTGCATCTTGGCTTTGCA
GCTCTTCCTCATGGCTGTTTCTGGCTGTTACTGCCACGGCACAGTCATTGAAAGCCTAGAAAGTCTGAAT
AACTATTTTAACTCAAGTGGCATAGATGTGGAAGAAAAGAGTCTCTTCTTGGATATCTGGAGGAACTGGC
AAAAGGATGGTGACATGAAAATCCTGCAGAGCCAGATTATCTCTTTCTACCTCAGACTCTTTGAAGTCTT
GAAAGACAATCAGGCCATCAGCAACAACATAAGCGTCATTGAATCACACCTGATTACTACCTTCTTCAGC
AACAGCAAGGCGAAAAAGGATGCATTCATGAGTATTGCCAAGTTTGAGGTCAACAACCCACAGGTCCAGC
GCCAAGCATTCAATGAGCTCATCCGAGTGGTCCACCAGCTGTTGCCGGAATCCAGCCTCAGGAAGCGGAA
AAGGAGTCGCTGCTGATTCGGGGTGGGGAAGAGATTGTCCCAATAAGAATAATTCTGCCAGCACTATTTG
AATTTTTAAATCTAAACCTATTTATTAATATTTAAAACTATTTATATGGAGAATCTATTTTAGATGCATC
AACCAAAGAAGTATTTATAGTAACAACTTATATGTGATAAGAGTGAATTCCTATTAATATATGTGTTATT
TATAATTTCTGTCTCCTCAACTATTTCTCTTTGACCAATTAATTATTCTTTCTGACTAATTAGCCAAGAC
TGTGATTGCGGGGTTGTATCTGGGGGTGGGGGACAGCCAAGCGGCTGACTGAACTCAGATTGTAGCTTGT
ACCTTTACTTCACTGACCAATAAGAAACATTCAGAGCTGCAGTGACCCCGGGAGGTGCTGCTGATGGGAG
GAGATGTCTACACTCCGGGCCAGCGCTTTAACAGCAGGCCAGACAGCACTCGAATGTGTCAGGTAGTAAC
AGGCTGTCCCTGAAAGAAAGCAGTGTCTCAAGAGACTTGACACCTGGTGCTTCCCTATACAGCTGAAAAC
TGTGACTACACCCGAATGACAAATAACTCGCTCATTTATAGTTTATCACTGTCTAATTGCATATGAATAA
AGTATACCTTTGCAACC
>gi|33468859|ref|NP_032363.1| interferon gamma [Mus musculus]
MNATHCILALQLFLMAVSGCYCHGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQI
ISFYLRLFEVLKDNQAISNNISVIESHLITTFFSNSKAKKDAFMSIAKFEVNNPQVQRQAFNELIRVVHQ
LLPESSLRKRKRSRC
IFN-gamma plays a critical role in Th1 type immune response. It is important for protection against infections by various viruses and intracellular bacteria.
Vaximmutor
The experimental data demonstrated that three time vaccinations with BCG in BALB/c mice induced strong TB Ag-specific IFN-gamma immune responses in splenocytes [Ref2101:Wang et al., 2009].
IFNG from Macaca nemestrina
IgA Fc fragment
Macaca mulatta
664734
90265825
NP_001035039
9544
19
60887587
60904465
+
Fc fragment of IgA, receptor for
7.75
30407.11
287
Also known as CD89
>gi|109156886:60887587-60904465 Macaca mulatta chromosome 19, Mmul_051212, whole genome shotgun sequence
GATGGACCCCAAAGAGACCACCCTCCTGTGTCTCGGTGAGTTTCAGAGTAAAAGTGGGTTAGAGGGGAAA
ACAGGGAAATCCCAAAATAATCCGGGTGTCTCTTGACAGTATGACTAGGAGATTTTAGTGGCTGCCAAGG
AGATTCTGACCTCCTTAGTGGAAAGGCAGTCTTTATCAATATGTCTATAACTTTGTCTCTGCCCAAGTCC
AACCTAGCTTGTGGGACTCAAGGGTTAATATTTTTATTAAACCTATAGTGTGTTATCTGGGATTAATGAT
GGTTCCAAGGTTCCCATCAAAGACAGACTTAGGGGCTGGAATCTGAAAGGTAAAAATAAAGAATGAGCCT
CAAAACTGTGATTGTTGTGGAATGAAAAAATATGATTGAACCCCATATAGAAATATGGTTACTAGTATTT
TGTTGAAGATTTTTGCATTTATGTTCAACAAAGACGTTATCCCGAAGTTTTCTGGTTTTGTTGCGTCTCT
GCCACGTTTTGTTATCAGGATGATGCTGGCCTCATAGAATGAGTTGGGGAGGAGTCCCTCCTCCTGGATT
TTTTCAATAGTTTCAGTAGGAATAATACTAGTTCTTCTTGGCCAGGTGCAGTGGCTCACGCCTATAATCC
CAGCACTTTGGGAGGCCAAGGCAGGTGGAACACACGGTCAGGAGATCACATCCTGCCTAACACAGTGAAA
CCCCGTCTACTAAAAATACAAAAAAATTAGCCAGATGTGGTGGCGGGCACCTGTAGTCCCAGCTACTCGG
GAGGCTGAGGCAGGAGAATGGCATGAACCTGGGAGGCAGAGCTTGCAGTGAGCTGAGATCGCACCACTGC
ACTTCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAATACTAGCTCTTCTTTATATATC
TAGTGGGACTGAGCTGTGTCTCCATCTGGTACTGGTCTTTTCCTGGTCTATCATTACAGAGGGTGATTTG
TCATAAAGATTGGAAATGGAAGCTTGATTTTTCATAAATCTCTCTCTTCCAGTGCTCTGTCTGGGCCAGA
GGATTCAGGCACAGGAAGGTAAGTGTCCTGTAAATCTCTCCCAGCCCCTTTAGACTCTCTTGGAAGCTCA
GGATAAAGAAATTGAGGAATAGCCTGAAGTACAGATTCTTATTTTAGTCCCCATTCCAGTTGTTTCTGCT
GTGCTTCTCTTGCATAATTTCTATCACACTTTGTTATAGCCAAATCCTTCAGACTCATTAATGCTCAGAC
CTGGATTTATAGTTAGTCCTTGCCTGTGTTAGACTGCCCATGAAGGATCTGTAATCTACTGAATGCTCAA
AACTGCAAGAATGAGGAAATCAGGAGTCATTTGCCCAACATCCTTCCTTATGCTTTGTTTTAGCAACCTA
CTTCCTCCTGTCACTTCATTTAAAGGGATACTGCCATAGTCTAATCCTACTGAACATTCTACTATTCTAT
AGTACTACTGCAGTACTAAGCATGCAGTAGTCTTAAGAGTACTACTGAATATTCTGCCACCCCAACTACT
ACTGCCTTAGCCTCCTAATGGGTGTAAGCCCCATGTCCATCCATGTCTGCTCTCTTCCAGCTCCTTCTAT
AGCCTGAATTATTTGTGTGTTGAACAATATTCATTCTTCCTATCCATGAGCATGGAATGTTTTTCCATCT
GTTTGTGTCATCTATGATTTCTTTGAGCAGCGTTTTGTAGTTCTCCTTGCAGATATCTTCCACCTCCCTG
GTTAGCTGTATTCCTAGGTATTTTATTCTTTTTGTGGTAATTGTGAATGGATTCTGTTCTTGATTTGGCT
CTTAGCTGAGACGTTTTTGGTGCATAGGAATGCTACTGATTTTTGTATATTGATTTTGTGTCCTGGAACT
TTGTCAGAGTCGTTTATCAGATTAAGAAGTGTTTGGGCAGAGATTGTGGTTTTCTAGGTATAGAATCACA
TCATCTGCAAACAGGGATGGTTTGACTTCCTTTCTTCCTATTTGGATGCCTTTCATTTCTTTCTCGCCTG
ATTGCTTTGGCTAGGACTTCCAGTACTATGTTGAATAGAAGTAGTGACAGAGGGTATCCATGTCTTGTGT
CAGTTTTCAAGGGGAATACTCCCAGCTTTTGCCCATTCAATATTATGTAGGCTGTGAGTTTGTCATAGAT
CTTCCTTATTATTTTGAAGTACGTTTCTTCAATGCCTAGTTTGTCGAGGTTTTTTAGCATAAAGGGATGT
TGGATTTTATCAAAAGCTCTATTGAGATGATTATATGTGTGTGGCCGGGGGATTGTTCTATGAATCACAT
TTAAGATTTGTGTATATTGAATCAACCTTGCATCCCAGAAATAAAGCCTACCTCATGGTGGTGGACTGGC
TTTCTGATGTGCTGCTGGATTGTTTGCTAGTATTTTCTTGAGGATTTTTGCATTTATGTTCAACAAGGAT
ATTGTCCTGAAGTTTTCTGGTTTTGTTGTGTCTCTGCCATGTTTTTGCATCTATGCGGGTCTCATAGAAT
GACTTGGGGAGGCATTCCTCTTCCTGAATTTTCTGGAAAGCTTCAGTAGATATAGTACCAGCTCTTCTCT
ATGTATCTGATGGGATTCAGCAGTGAGTTTGTCTGGTACTGGCCTTTTTCTTCTTTTGAAGAGGCCTTTT
TATTACTGATTCAATTTTGGAGTTCATTATTGGTCTGGTTCATGGAATCAGTTTGTTCTTGGTTCAATCT
CAGAAGGATGTATGTGTCCAGGAATCTCTCCATTTATTCTGGATTTTCTAGTTTGTGTGCACAGAGGTGT
TCCTAATATTCTCTGATGATTGTATTTCTGTGGGGTCAGTGGTAATATCCCCTTTGTTGTTTCTAATTGT
GTTTATCTGGATCATCTCTCTTTTCTTCTTAATTAGTCTAACTAGTCACCTGTCTTACTAATTTTTTTCA
AAAATCCAACTCCTGGATTTGCTGATCTTCTGAATGGTTTTTTGCATCTCAATCTCCTTCTGTTCAGCTC
TGGTTTTGGTTATTTCTCGTTTTCTACGAGCTTTGGGGTTGATTTCCTCTTGGTTCTCTCAGTTCCTCTC
GTTGTGATGTTAGGTTGTTAATTTGAACTTTTTCTAACTTTTTGACGTGGGAGTTTAGTACTATAAACTT
CCCCCTTAACACTGCCTTAGTTGTGTCCCAGAGATTCTGCTGTATTTACCCACAAATTCCAGAACAGACT
GTTTAATTTCCATGCATTGTACAGTTTTGAGTGGTTTTCTTAGTATCTATTCCTATTTTTATTCCACTGT
GCTCTGAGAATGTGCCTGGTATGATTTCACTATTCTGGATTTGTTAAGGATTGTTGTATGTCTGATTGCA
TGATTGACTTTAGAGTATGTGCCACGGGGCAATGAAAACAATGTAGATTCTGTTGTTTTGGGGGTGGAGA
GTTCTGTAGATGTCCATCAGGTCCCTTTGGTCCAGTGCTGAGTTCAGGTCCTGAATATCTTTGTTTGCCT
CAGTGATCTAACACTGTTGACGAGATGTTAAAGTCCCCCCCTATTATTGTGTGGTTGTCTAAGTCTCTTT
GTTGGTCTCTCAGAACACGCTTTATGAATCTGGGTGCTTCTGTGTTAGATGCATGATATTTAGGATAGTT
AGGTCTTCATGTTCTGTCTTTATTTTTTTCTTTTTCTTTTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TGAGATGGAGTCTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGTGCAATCTCGGCTCACTGCAAGCTTCA
CCTCCCGGGTTCACGCCATTCTCCTGCTTCAGCCTCCCGAGTAGCAGGGACTACAGGTGCCTGCCACCAC
GCCCGGCTAGTTTTCCAACATGGAAAACTATGTTTTCCATATTGCTTGCTTTCTCCCCATCTCTTTCGGG
GACCCCAATGGGTTGCCTATTTGGTCTCTTTACATAATCCCATGTTTCTTAGAGGTTTCAAATTTCATTC
ATTCTTTTGTATTCTTTTGTCTTCATTTTTGTCTGACTGAATTAGTTCAGAGAGCCAGTATTCATGCTCT
GAGATTCCTTCCTCGTTTTGCTTTATTCTGCCGTTAATACTTGTGATTGCATTATGAAATCTTGCAGTGT
GTTTTTCAGCTCTATCAGATCCGTTCGGTTCTTTCAAAATGACCGTTTCTTAGATTAGCCCCTGTGTCAT
TTTATCGTAATCTTTCGATTCCTCGCATTGGGTTTCAACTTTCTCCTGAATTTGATGACCTTGATTTCTA
CTCATATTCTGAATTCTATTTCTGTCATTTCAGCCACTTCCTCCTGGTAAAGAGCCCTTGCTGGGAAGCT
CATGTGGGAATTTGGAGGAAGGAAGACACTTGCTTTTTGAGTCTTGTGCTAATTCTTTCTCATCCGTGTG
GGCTAATGTTCTTTTAAGTGTGGTGCAATTGGAGTGTTTTTCTTTTTTCTTTTAACTGTGGTGTAATTTG
AGTACAGTCAGTAGACTTCTTTTCTGGGTGGTTTCAGAGGGCTGGGGCTTCGCACAGGGTCTTTACTGAT
AGCTAAATTCTTGTCCTTGGTATAACGGGGGGTATATTAGCAAGCATTTTTGGTGTTGAAGTTTGGGCTG
CAATCCAGTAAGTGATGCTTAAGCATAATGGCCAGTAGGTCATTCCTCATGACGGCCGCTGTGCTCCCTC
TCATGCTCTGAATGTGTGGGCTCCTCTCCCACTCAAGCACTGGCTGCAGATCTGGGCTCCGCACTCCCAG
GCTGCCCATCACAGCGCTGGGGTGAGCTCAGGTTTTATGTTCCCTCCGTGGCTTGGGGGCAGCAGGGGAA
GGGACCTCAGCAGTGGCTGTGGCAGATGGCCTTTCACTTGTCCCTTGGGACTCCACCCCAGAGAGATGTG
GAACCACTATCAGTAGTGTGATGAGCCAAGAGTGGGGCGACTGCGCTGTGGGCCCAAGCTAGGGGCCCTG
CCTAGTGATGAGCAGCGGGGACAGGTGGGTCACAGGGGTGACAGACTGGCCTCTTCTCCTTAGGGCAGCT
TGCGGGAGGTGTGGTTAAGGCACTCAGAGTCTTTGCTCCTTCCCCAGTCTGAGGGCAGCAAGGCCAGGAC
CACCGCAGTGGCAGCCGCAGAGGGGCTGTGAGTTGCCTCTGGGAGCTCCGCCACAGAGAAATGCAGACCC
ACAGCTCCCAGGCACGCTCCGCAGAGGGTGGGGCTGCTGTGCTGCGGGCTCAGGCTGGGGTTTGGTGAAG
AGCAGGGGGCTGAGGGCTCGCAGGGAGAGGAGACTGAGCTCCTCTCTTACGGTGACTGTGGTGTGCTAGA
GGCATGAATGAAGGCTGGGGCTCGGCGGCTCACACCTGTCATCCCAGCACTTTGGGAGGCCGAGGCGGGC
GGATCACGAGGTCAGGAGATCGAGGCCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACA
AAAAACTAAGCCGGGCGTGGTGGCAGGTGCTTGTAGTCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCTACAAA
TGCTCAGTAAAAAAAATACTAATAATAAAATAAAATAAAATAAAGCATGAATGAAGCTCCTAGGCTCCTT
GTTCTTCCTCAGACCACAGGCAGCAGGGGCAGAATCCTTGCCATGGCGGTGGCAGAGGGGCCGTCAGTTG
CCTCTGGGAGCCATTCCCCAGGGAAACACGGAGCCACCACCAGTGAGGATGCTGAGGGTAGGGCAGCTGC
TCTGCAGTCCCAAGCTGGGGGCTCTGCCTGGTAAAGTGGGGGTGGGGGCTCACGGGGAAGAGAGACTAGA
CTCCTCTCTGTCTGATGGCTGTGGCATAATGACCAGTCCCCAACACGTGAAAAAGAATTGTGGGAACTCA
GAAACCCAGTTTGTCCCCACCATGGACTCCTTGCACTGCGTTTCAAATTTCTCCTCAATCTCCATGAGCT
TCCCAGCCATCCAGATTCTGAATTCTATGTCCCTCGTTTCATTCATCTCAATCTAGCTAAGAACCAGATT
TCCAGGGGACTATCGAGTTGCCAGAGTTCTTGTGTTCCTTTTATTTTTTCCTTTTGTGTGACAAGAGTCT
TACTCTGTTACCCAGGCTGGGGTGCGGTGGCGTGATCTCAGCTCACGGCTGCAACTTTCACCTCCCAGGT
TCAAGCTATTCTCCTGTCTCAGCCTCCCAAGTAGCTGGGATTACAGCTGCGTGCCACCACACACAGCTAA
TTTTTGTATGTTTAGTAGAACCCAGGTTTTGTCAGGTTGGTCAGGCTGGTCTTGAACTCTTGACCTCCGG
TGATCCGCCCGCCTGGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCGGCCTTGGTGT
CGATTCTTTCTCTTGTGTGAGGGCTGGTGTTCCTTTAACTGTGATGTCAGTTGAATACAGTCACTTAGCT
TCATTTCTGGGTGTTTTCAGATGCCAGGACTCTGCACGGAATCTTTATTTGTGGCTGGATTTTTCACTTC
GTTGTCTACTGGCAAAATATTTCAGTCTTGTATTTTGACGTGTGATCCAGTAGGTGGCACTTAAAAGGGG
CTGGCCAGCATACAGGATCTTAGCCACAAGGCTGTTTTGTAGTTTTGTTTCGTTTTTTGTTTTGTTTTTT
GACACAGGGTCTTGCTCTGTCACCCAGGCTGGAGCGCAGTGGCACAGTCTCGGCTCACTGCAGCCTCCAT
CTATCAGGCTAAGTGATCCTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTACAAGCACATACCACCATAC
CAAGAAAATGTTTGTAATTTTTTTTTTTTTTTTTTTTTAGAGATGGGGTTTCACCATGTCTGCCAGGCTG
GTCTCAAACTCCTGGGTTTAAGTGATCTGCCTCCCTTGGCCCCCCAACTCTTGTATTTTGACAAAGTTAG
CAGTAGTGCTCTGTGGTTGTGGGGAGGGGTGACTTCCTCACCTGGTCCATTCCTGGGCCTTGGAGGAGCC
TCCTACAATCACTAGCTCTGCACCCACCGTTTCCTTTGTTAGGATTGTTCTGCCCACGGGGTTCCTTCAG
GCAGTGCATGGTGGGAAGACAGGCTGTATCCTTCCCCAGCCAGCCTACGGAGGGAGGACCACCCCACTCC
TCTGCAGACTGATGAAATCACGTGTTTCATTCTTCTGAGTGTTCTGAGAATGAGGGCTCCTCACCGCTCA
GTCGCCACCCAAGCTGGTGAGTCCTTCTCAGCAAGGGCGGTTGGAACCACCTGATCTGCCATCTCAGTGC
TTCCCAGGGGAACCCAGAGCTGCTGGGGCATGGCAGCTCATGCCTGTAATCTCAGTACTTTGGGAGGCCA
AGGCGGGCAGATCACGAAGTCAGGAGATCGAGACCATCCTGGATAACATGGTGGAACCACATTTCTACTA
AAAATACAAAAATTATCCAGGCATGTGGCGGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGA
GAATTGCTTGAACCCGGGAGGCGGAGTTTGCAGTGGGTCGAGATTGCGCCACTGCACTGCAGCCTGGGCG
ACAGAGCGAGACTCTGTCTCGAAAAATAATAACAAAAAAAAATAAAGATGGCAACCACAGACACTGGAGA
CGACTAGACGGGGAGGAAGAGAGGGGCTTGAAAAACTAACTGCCTACTGGGTACTACGCTCAGCACCTGG
GTGACAGGATCCACCGTACCCCAAACCTCAGCATCATAAATTATTTACATGTTTATTTTTATTTATTTAT
TTATTTTAATTGAGACAGAGTCTCACTCTGTGGCCCAGGCTGGAGTGCCATGGCGGGATCTCAGCTCACT
GCAAGCTCCGCCTCCTGGGTTCACGCCACTCTCCTGACTCATCCTCCCAAGTAGCTGGGACTACAGTCGC
CCACCCCCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGAGGTTTCACCATGTTAGCCAAGATGG
TCTCGATCTCCTGACCTCGTGTTCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCA
CCACACCTGGCCTAAATTTTTCTTTAAATAAAGAATGACAGGTTCTTCATACCCTAATTTTCTTCCAGGG
AACTTTTCCACGCCTTTCATATCTACCAGGTCAAGTCCTGTGGTTCCCTGGGGTGGGTCTGTGAGAATCC
AGTGCCAGGCCATTCCTGACGCTTACCTGATCTGGCTGATGATGCTAAAAAACTCCACGTACGAGAAGAG
AGACGAAAAACTGGGGTTTTGGAATGATACTACGCCTGAGTTCGTCATTGACCACATGGACGCGAACAAA
GCAGGGCGCTATCAGTGCCGATATAGGATAGGGTTCTCCAGGTTCCGGTACAGTGACACCCTGGAGCTAG
TGGTGACAGGTAAGGAAACATCCAGGGTCCACAGCCCTGGTGTGATTTTTTTTCTTATTTTTAATAGAGT
ATTTTTCGATAAGTTTTAGATTTACAGAAAAAAGAAAAATTGAGATGACTGCTTCACAGAGTTCTCAGCT
ATCTGGCCACTTCCCCCAGAGTTAACATCTGACATTACTATGGCACATTTCTTTTTTTTTTTTTTTTTTA
ATTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCCGGATCT
CAGCTCACTGCAAGCTCCGCCTCCCGGGTTTACACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGAC
TACAGGTGCCCGCCACCTCGCCTGGCTAGTTTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCGTGTTA
GCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAG
GCGTGAGCCACCGCGCCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
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NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCACACACAC
ACACACACACACACAGAGGTTACACACACACACACACACACACAGAGGTTACACACACACACACACACAG
AGGTTACACACACACACAAACACACACACACAGAGGTTACACACACACACACACACACACAGAGGTTACA
CACACACACACACACACACAGAGGTTACACACACACACACACACACAGAGGTTACACACACACACAAACA
CACACAGAGGTTACACACACACACACACACAGAGGTTACACACACACACACACACAGAGGTTACACAAAC
ACACACACACACAGAGGTTACACACACACACACACAAACACACACACACACACACACACACACACAGGTT
TCACTTTGCATTCAGGTGTCATGTATCTTTAGCTTTCTCCCGGCTCTCACAGCTTCTCCGATGTTGCTGG
TTTTCCATGGCCTTGTCAGTTTTGAGAGTAGAAGTCCATCACTTTCATTGGCCGGGCGCGGTGGCTCAAG
CCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGG
CTAACACGGTGAAACCCCGTCTCTACTAAAAAATACAAAAAAACTAGCCGGGCGAGGTGGCGGGCGCCTG
TAGTCCCAGCTACTCGGGAGTCTGAGGCAGGAGAATGGCGGGAACCCCGGAGGCGGAGCTTGCAGTGAGC
TGAGATCCGGCCACTACACTCCAGCCTGGGCGGCAGAGCCAGACTCCGTCTCAAAAAAAAAAAAAAAAGT
CCATCACTTTCAAGGGTACTCCCACTATTGGAAATTGTCCGATGTGTTGCTCATGACTAGACTGAGTTAT
GGGTTGTTGAAGACCACAGAAGCAAAGTGCCGTTTCATCTCCTCATAGCAAAGGTTTAAACTGTCCATGG
GAATATGACTGTTGATGCTGAACTGGCTGTTGTTGAAAGCCTGGCTGAAGTAGTGACTGTGACCAGGCAC
CGAGGCTCACGCCTGTAATCCCAGCGCTTTGAGAGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCA
CTTTGGGAGGCCGGGCGCAGTAATCCCAGCGCTTTGAGAGGCCAAGACAGGCGGATCACTTAAGCCCAGG
AGACCAGCCGAGGCAACATAGTAAGACCCCATCTGTACAAAAAAAACAAAAAATTAGCTGGGCATGGTGG
CACCCACCTGTAGTCTCAGCTACTTGAGAGGCTGAGATGGTAGGATCACTTGAGCCTGGGAGGTCGAGGC
TGCAGTGAGCCGCGATTATGCCACTGCCCTCAGCCTGGGCGACGGAGTGAGACCCTCTCTAAAATAAATA
AATAAATAAAATTTTAAAAAGAAAAAAGAGGCTGGGCACTGTGGTTCACGCCTGTAATCCCAGCACTTTG
GGAGGCTGAGGCGGGTGGATCACCTGAGGTCAGAGATTCAAGACCAGCCTGACCAACATGGTGAAACCTC
GTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGGAGGTGCCTGTAATCCCAGCTACTCAGGAGG
CTGAGGCAGGAGAATCACTTGAACCTCGGAGGTGGAGGTTGTGGTGAGCCAAGATTGTGCCACTGCACTG
CAGCCTCGGTGACAGATCGAGACTCCATCTCAAAACACAATAATAGGCCGGGTGCGGTGGCTCACGCCTG
TAATCCCAGCACTTTGGGAGGCCAAGATGGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGACC
AACATGGAGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGCACACCTGTAATC
CCAGCTTCTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGTAGTGAGCCGAGA
TCACACAATTGCTCTCCAGCTTGGGCAACAAGAGCAAAGCTCCGTCTCAAAAAATATATATAATAATAGC
AATAATCAGAAGAAGAAAAAAATAAAGGAGAAAAGGTCTTGCTAACAGCTCACTCTTCTCTCTCTTAGGC
TTGTATGGCAAACCTTCCCTCTCTGTGGATCGGGGTCCAGTGTTGATGCCGGGAGAGAATATTTCCGTCA
CGTGCAGCTCAGCACACATCCCATTTGATAGATTTTCACTGGCCAAGGAGGGAGAACTTTCTCTGCCACA
GCACCAAAGTGGGGAACACCCGGCCAACTTCTCTCTGGGTCCTGTGGACCTCAATGTCTCAGGGAGCTAC
AGGTGCTACGGCTGGTACAACAGGAGCCCCTACCTGTGGTCCTTCCCCAGTAATGCCCTGGAGCTTGTGG
TCACAGGTAGGTACCTCCCCATCCAGCCCTGTGTCCGGGTTGGCTGTCCAGGCCCTTGTCACTGGGCAGG
AATATGAATATGAAGAGGTGCACTGAGAATAATGTGAAGAGAGGCAAAGACTCACCCACTCCAGGACAGT
GGAGAAAGAAAGTCTTCCCATCACACTTTCCACCTTCACTTCCTCGCTAGAGTTCTCCAGACAGTGTTCA
TTGAAAACTTGTGGTCTATGGAGAAAAGAAGGACTGACTCATTTTATTTTATTTTATTTTCTGTGATGGA
GTCTTGTTCTGTCGCCAAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTTCGCCTCCCGGG
TTCAAGCAGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACCATGCAGAGTTTCACCATGTTGTTCAGG
CTGGTCTCGATCTCATGACCTTGTGATCCACCCACCTCAGCTTCCCAAAGTGCTGGAATTACAGGCGTGA
GCCACCGTGCCCAGTCAAAAAAGGCTAACTTAGAGTCACAGGTTTATGGGCTATGTTGAGACAGTAGATA
CCAGGCTCAACCTTGTCTACCACACCTCTCCTTTCCAGTTGCAGCTGGAAATCCTCGAACTCACCAACCG
TACTGGAATTTACCATGAGTAATCAAATGGTCATTCATGGTGACCATTTAGTGACCAAATAGTGAGTGAG
GGGTCAAATAGTGACATATTTGGTGACCAAATAGTGAGTGAGAGGTCATAGGAAAGACTTTTAAAACCTC
TATCATGAGCCCCATTTTTATTTTATTCATTTATTTATTTTGAGACAGAATCTCGTTCTGTCGCCCAGGC
TGGAGTGCAGTGGCACAATCTCTGTTCACACTGCAACCTCCACCTCCCAGGTTGAAGCAATTCTCGTGCG
TCGGCCTCCTAAGTAACTGGGACCACAGGCGTGCACCACCGCACCAGGCTACTTTTTGTATTTTTAGTAG
AGATGGGGTTTTGCCATGTCGCCCAGGCTAGTCTCAAACTCCTGGCCTCAAGTGATCTGTCTGCCTCAGC
CTCACAACGTGCTGGGATTACAGGCGTGAGCCACCACGCCTGGTGGTGAAGACTCTAAAGGCTCTTCTCA
GACCAGCCTTTGTCCTGAGGGTCACATGCCCGTGTCCAGTTACCTCTCCAGCATCTTTTCAGGAGTTCCA
CGGACTCGCCCCTTCATTATCCAGGGTTGAGCTACAGATATTCTGATTAGGATTCCACCTAGTTCTGGTG
GTGGTGTAGAGATATGATTAGATATTTAGTGAAATCACCAAGTGAGGAGAGAATGAAAAGAAAACACAAC
TTGCCTGGCCGGGTGTGGTGGCGTGAGCCTGTGGTCCCAGCTACGCAGGAGGCTGAGGCAGGAGAATCGC
TTGAACCCAGGAGGCGTTGGTTGCACTGAGCCAAGATTGCGCCATTGCACTCCAGCCTGGGTGACAGAAT
GAGACTCCATCTCAAGAAAAAAAAAAAAAAACATGGCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCA
CATTGGGAGGCTGAGACGGGCGGATCACTTGAGGTCGGGAGTTCGAGACCAGCCTGGCCAACATGGTGAA
ACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCGGGCGCCTGTAATCCCAGCTACTTG
GGAGGCTGAGGCAGGAGAATCGTTTGACCAAGGAGGTGGAGGTAGTAGTGAGCCGAGATCGCGCCACTGC
ACTCCAGCCTGGGCGACAGAACAAGACTCCGTCTCCAAAAAAAAAAAAAAAACAACCTGCCCGTAATCAC
TCCCTTCCCAGTTTATGGAACTTCCCTGCCTGTGGACACAGTCCTGCTGACTGATCAATGTGGTGCTTGC
AAAGTGTGAGCCCATCGAGGAGATGCCTGAGGGAGTCACATTTTGGCAAGCGAATAGGGAAATGGGCTCC
CGTTTCAGGGCTCTGGGGTTGGGATGGAATGGAACACACCCGCCAACCATTCATCTCCCCGAATTGTGTC
TCCAGACTCCATAAACCGAGATTACACGACGCAGAACTTGATCCGCATGGCCATGGCAGGACTGGTCCTC
GTGGCTCTCTTGGCCATACTGGTTGAAAATTGGCACAGCCATAAGGCGCTGAACAAGGAAGCCTCGGCAG
ATGTGGCTGAACCGAGCTGGAGCCACCAGATGTGTCAGCCAGGATGGACCTTTGCACGAACACCAAGTGT
CTGCAAGTA
>gi|90265825|ref|NP_001035039.1| immunoglobulin alpha Fc receptor precursor [Macaca mulatta]
MDPKQTTLLCLVLCLGQRIQAQEGNFSTPFISTRSSPVVPWGGSVRIQCQAIPDAYLIWLMMLKNSTYEK
RDEKLGFWNDTTPEFVIDHMDANKAGRYRCRYRIGFSRFRYSDTLELVVTGLYGKPSLSVDRGPVLMPGE
NISVTCSSAHIPFDRFSLAKEGELSLPQHQSGEHPANFSLGPVDLNVSGSYRCYGWYNRSPYLWSFPSNA
LELVVTDSINRDYTTQNLIRMAMAGLVLVALLAILVENWHSHKALNKEASADVAEPSWSHQMCQPGWTFA
RTPSVCK
Vaximmutor
IgG Fc fragment
Macaca mulatta
718859
383873191
EGK_10892
CM001271
NP_001244449
9544
19
55776057
55793029
+
3
6.71
38189.56
365
>gi|109156886:55776057-55793029 Macaca mulatta chromosome 19, Mmul_051212, whole genome shotgun sequence
AGAAGGATATTAAAGAGCACCTGCAGGACCTTTCTAACGGGATGTCGGGGGAAGGGCTTGAAGGAGGATC
TAGGGAGGCTTCCATAAGATTTTGATTAACATCCAGCGCTAGGGAAGGTCACAGGGATACAAAAGGGTAG
GAGGAGGATCCAGAGACCTGCATGTTGTGGACTTCGAAGGCATCCGGTTCCTTTCCCAGCTTTGTCAAGA
ATTCCCTGGGCGGCGGACACCCTCATAATAAAAAAAACGGGAACCACAGGGAAGGGGAATAGAAGAACCA
CAAGCGTTTTGAGAAACATACATAGGCTGGGCCTAGGGCCTGGGGTGTGCCCTGCAACTGGGGGGGGTGG
GGCTGGATGTTCTTGGAGTCAGGGAGCAGCAGCCTCCCACAGGATGTGAGAGAGGAACTGGGGTCTCCAG
TCACGGGAGCCAGGAGCCGGCCAGGGCCGCAGGCAGGAAGGGAGCGAGGCTGAAGGGAACGTGAGCCGAC
CAGGCCCCGATTGAGGGAGGAGGGAAGGGCCTGGACCCCTGGGCCTGAGGGAGGAGGGGCTGGGGGTCTG
GACAGTGCGTCTGAGGGAGGAGGGGCTGGGGGGGTCTCGACACTGGTTCTGAGGGAGGAGGGGCTGGGGG
CCTGGACGCCTGGGACGGAGGGAGGAGGCACTGGGGGTCTGGACACTGGGTCCGAGGGAGGAGGGGCTGG
GGGCCCGGACTCCTGGGTCCGAGGGAGGAAGGGTTGGGGGCCCGGACTCCTCGGTCGGAGGGTGGAGGGG
CTGGTGGCCCGGACTCCTGGGTCCGAGGGAGGAAGGGTTGGGGGCCCGGACTCCTGGGTCAGAGGGTGGA
GGGGCTGGTGGCCCGGACTCCTGGGTCCGAGGGAGGAAGGGTTGGGGGCCCGGACTCCTCGGTCGGAGGG
TAGAGGGGTTGGGGGCCCGGACTCCTCGGTCGGAGGGTGGAGGGGCTGGCGGCCCGGACTCCTGGGTCCG
AGGGAGGAAGGGTTGGGGGCCCGGACTCCTCGGTCGGAGGGTGGAGGGGCTGGTGGCCCGGACTCCTGGG
TCCGAGGGAGGAGGAGCTGGGGGCCCGGACTCCTCGGTCGGAGGGTGGAGGAGCTGGGGGCCCGGACTCC
TCGGTCGGAGGGTGGAGGGGCTGGGGGCCCGGACTTCTCGGTCGGAGGGTGGAGGGGCTGGGGGCCCGGA
CTCCTCGGTCGGAGGGTGGAGGGGCTGGGGGCCCGGACTTCTCGGTCGGAGGGTGGAGGGGTTGGGGGCC
CGGACTCCTGGGTCCGAGGGAGGAGGGGCTGGGGCCTGAGGGGGACGGAAGGGGCGTGGCCGAGCTCGGG
GCCGGGACTCTCAGCCTATCAAGTTTCTGTAATTAATTAACTAACTGAGATCCAGTTCAGGGGTGAAAGT
TCTTCAGGTAGGAGGAGGGCATTGTTGTCAGTCTGGACCGAGCCCGCAGAGCCCCTCCTCGGCGTCCTGG
TCCCGGCCCCTGCCCCGGTACCCCGGGAGGAAGGGCGGGGCCGGGGGTTTTTCGGGAGGAGTCACGTGCC
CCCTCCCGCCCCAGGTCGTCCTCTCAGCATGAGGGTCCCGCGGCCTCAGCCCTGGGCGCTGGGGCTCCTG
CTCTTTCTCCTGCCCGGGAGCCTGGGCGCAGGTGAGGGCCGCTGCGGGCCGGGGCCCTGCTGCAGGCGGG
CGGTGGGAGGCGGCCCCAGGCAGGCAGGGGCGAAGCCAGCGGGACCCGAGTTCCCCGCGAGTCCCGGGCG
CTGCCTTCTCCGCTCAGTTCACTTTCTCAGCGTCTCCTGCTGGGCCTGAGGCTGAGAACCACCTGTCGCT
TCTGTGTCTCTGTTTCCCTCTCTCTCTCTCTGGGTCTCTGTCCTCTCTCTCTCTCTGGGTCTCTGTCCTC
TCTCTCTCTCTGGGTCTCTGTCTCTGTCTCCCTCTCTCTCTCTGGGTCTCTGTCCCCTCCCTCTGAATCT
TCCCTCTCCATAATAGATTCTTCTCCCTCCCTGGATATCTGTCCCACTGCAATCTAGTTCCCCGCCCATG
TTCTCCCTTCAGCTCTGTCTCTGTCTGCAGAAAGTCACCTCTCCCTCCTGTACCACCTCACCGCGGTGTC
CTCGCCTGCCCCGGGGACGCCTGCCTTCTGGGTGTCCGGCTGGCTGGGCCCGCAGCAGTACCTGAGCTAC
GACAGCCTGAGGGGCCAGGCGGAGCCCTGTGGAGCTTGGGTCTGGGAAAACCAAGTGTCCTGGTATTGGG
AGAAAGAGACCACAGATCTGAGGATCAAGGAGAAGCTCTTTCTGGAAGCTTTCAAAGCTTTGGGGGGAAA
AGGTGAGATTCGAATCCGGAGGGGCAAGGGGCTGGGTCCATGCTCCTGGGCCCCACTTACATGTGTGTGG
GCGCCCCAGGCCCCTACACTCTGCAGGGCCTGCTGGGCTGTGAACTGAGCCCTGACAACACCTCGGTGCC
CACCGCCAAGTTCGCCCTGAACGGCGAGGAGTTCATGAATTTCGACCTCAAGCAGGGCACCTGGGGTGGG
GACTGGCCCGAGGCCCTGGCTATCAGTCAGCGGTGGCAGCAGCAGGACAAGGCGGCCAACAAGGAGCTCA
CCTTCCTGCTATTCTCTTGCCCACACCGGCTGCGGGAGCACCTGGAGAGGGGCCGTGGAAACCTGGAGTG
GAAGGGTGAGCCGGATCTGCAGCCACAGGCTGTTCTGTCCTCTCTGCCATCACGCCCACCTGCCTCAGTT
CCCCTGTCAGGACCCTCAGTCAGCCTCCCACTGCAGCCCACGCTCTGCCCCCATTCCTCAGGGGTTTTTC
TACATTCAGCCCTCCCATGGCTCCCCAGCGCCCCCCAAGACAAACTCTTGGCTTCCTTGCCTTTTTTTGT
TGAGACGAAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGTAACCTCC
GCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCTAGTAACTGGATTACAGGCATGCATCACCAT
GCCTGGCTAATTTTGTATTTTTAGTAGAGGCGGGGTTTCTTCATGCTGGTCAGGCTGGTCTCAAATTCCC
AACCGCAGGTGATCCGCCCGTCTCAGCCTCCCAAAGTGCTGGGATTACAAGCGTGAGCCATCGCACCTGG
CTGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGATTCTCTGTCACCCCAGGCTGGAGTGTGGT
GGCACAATCTCAGCTCACTGCAGCCTGAACCTCCCAGGCTCAAGCAATCCTCCCACGTCAGCCTCCCAAG
TAGCTGCGACCACAGCATCGTCACACCTGGCTGACTTTAATTTTTATAGACACAGTGTCTCACTACGTTG
CCCAGGCTGGTCTTGAACTCCTAGGCTCAAGCAGTCTTACTGCTTTGGCCTCCTGAATAGCTGAGATTAC
AGGTGCATACCACCATAACTGGCTAATTTTTTTTTTAGTTTTCCGCACAGTCTGCCTCCCAGGCTAGTGT
GCAGCAGCGTGATCTCAGCTCGCTGCACACTCTGCCTCCTGGGTTTAAGCGATTCTCCTGCTGCAGCCTC
ATGAGTAGCTGGCACTACAGGCACATCCACCATCTCTGGCTAATTTTTGTAGTTTTAGTAGAGACAGGGT
TTCGTCATGTTAGCTAGGCTGGTCTCAAACTCTTGACCTCAAGTGATCCACTCACCTCAGCCTCCCAAAG
TGGTGGGATTACAGGCGTGAGCCACCGCATTTGACCATAACTGGCTAATTTTTAAAATTTGTTGTAGAGA
TGGCATCTCGCTGTGCTGCCCAGGCCAGACTCAAACTCCTGGCCTCAAGTGATTCTCCCACTTTGGCCTC
TCAGGGTGCTGGGATGACAGGTGTGAACCACTGTGCTTGGCCTTCCTTGCCTTAATGCCCTCGTCAGACC
CACGCAGCAGCACTTGTCTCTACACAGCTGTCAGAGTCTAGGCTCCAGCCACCCAACATGAGCAATCTTC
TCCCTCTGAGCATTTGTTCATCCAGTTCCCCCGGCCCCTCTCTGTTCCACCCTTCCCCCTCTCTGCATAT
ACTCCAGCCCTCCTTATTCTTCAAGGTCGGGGCTGGATATCACTTCCTCTGAGAAGCCTTCTCTCAGCTC
TGTAGGGCAGAGTTCACTGTTTCCTCCCCAGCGGCCCCAGATCCCCATTCATTCAGCTGTTGGCCAAGAG
CATTTGCACTGCCAGACACCGCTCTGGGACGCCGCTCTGGGCCTTGAGCAAAGAGGGAAGTGACACACGT
TCACCCTCTGTGGCTTCCAGGCTGCTGGACAAAGATAGATATCGGCTGGGGATTTGCACAGATGTTCATT
CCAAGTGCCACAAAGGAGAAGTTGAGACTTAACCAGGTAGTTTTTCTTTGATCGTCTTCTTTCTTTTTTA
AGTAGGGAAAATTTCCTTTTTTTTGAGATGGAGTCTCGCTCTTGTCGCCCAGGCTGGAGTGCAATGGCGC
AATCTCGGCTCACTGCAACCTCCGCCTCCCAGCTTCAAGTGATTTCTGCCTCAGCCTCCCGAGTTGCTGG
GACTACAGGCACGTACCACCATACCTGGCTAATTTTTGTATTTTTTTTAGTAGAGACAGGGTTTCACCAT
GTTGGCCGGGATGGTCTTGATCTCTTGACCTTGTCATCCGCCTGCCTCGGCTTCCCAAAGTGCTGGGATT
ACAGACATGAGCCACTGTGCCCGGCCTTTTTTTTTTTTTTTTTTTGAGACAGACTTTTGCATTGTTGCCC
AGGCTGCAGTGCAGTGGCACAGTCTTGGCTCACTGCAACCTCCACCTCCCAGGGTCAAGCAATTCTCCTA
CCTCAGCCTCCCGAGTAGCTGGGAATACGGGCACGCACCACCCTGCCTGGCTAACTTTTGTATTTTTAGT
AGAGACGGGTTTCACCATGCTGGCCAGGCTGGTCTCGAACACCTGATCTCGTGATCCGCCCACCTTGGCC
TCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCACACCTGGCCTAAGTAGGGAAAGTTTCAAACCACAC
TTAAGTAGACACAATAGTATAAAAAGGACCAGGCATGGTGGCTCATGCCTGTAATCACAGCATTTTGGGA
GGCCAAGGCAGGTGGATTGCTTCATCCCAGGAGTTCAAGACCAGCCTGGGCAACATAGCAAGACCTCATC
TCTACTAAAAACTCAAAAAATTAGCCTGGCATGGTGGTATGTGCCTCTAGTCCCAGCCACTGGGGAGGCT
ATGGTGGGAGGATCACTTGAGCTCAGGAGTTTGAGGCAGTAGTGAACTGTGATTGCAATCCTGCACTCCA
GCCCAGACTACAGAGCCAGACCCTGTCTCAAAAAGAAAAAAAATATGATGGCCAGACGCGGTGGCTCATG
CCTGAATTCCAACACTTTGGGAGGCTGAGGTGGGCAGATCACTTAACAGGAGTTTGAGATAAGCCTGGCC
GACATAGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGCGGTGGTGGGCGCTTGTAATC
CCAGCTACCCTCCACTTCAAGTGATCCACCCTCCTTGGCCTCCCAAAGTGCAAGAGTCACGGTGCCCGGC
CAGAGTGTTTTGTTGATAAGTACTTTAGTATGTAACTCTACTAGGTAAGGGCATGTAAAAAAAATTAATA
CCAAAACCATTATCACACCTACGATCAATTAACTGTAACTCCTTAATGGCATCAGATGTCTAGTTTTTGT
TCACATTTTCCTGACTGTAAATTTTTTTTTTTTTTTTTTGAGACAGTCTCTTTCTCTGTCACCCAGGCTG
GAGTGCAGTGGCCGGATCTCAGCTCACTGCAAGCTCCGCCTCCCAGGTTTACGCCATTCTCCTGCCTCGG
CCTCCTGAGTAGCTGAGACTACAGGCGCCTGTCACCTTGCCCGGCTAGTTTTTTGTATTTTTTTTTTTTT
TGTTTGTTTGTTTTTTTTGAGACGGAGTCTGGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCCGGATCTCA
GCTCACTGCAAGCTCTGCCCCCCGGGTTTACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTA
CAGGCGCCCGCCGCCTCGCCCGGCTAGTTTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCGTGTTCGC
CAGGATGGTCTCGATCTCCTGACCTAGTGATCCGCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGC
TTGAGCCACCGCGCCCGGCCGTTTTTTGTATTTTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGA
TGGTCTCGATCTCCTGACCTCGTGATCTCCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNGCACACCACCATGCCTGGCTATTTTTTGTATCTTTAATAGAGACAGAGTTTCACCAT
GTTGGCCAGGCAGGTTTTGAACTCCCGACCCCAGGTGATCCACCTCCCTCGGCCTCCCAAAGTGTTGGGA
TTACAGGCATGAGCCACCGCGCTCAGCCGTATTTTTGTTTTCTTTTTTTTTTTTTGGAGACGGAGTCTCG
CTCTCTCGCCCAGGCTGGAGTGCAGGGGTGCCATCTCAGCTCACTGCAACCTCCACCTCCCGGGTTCAAG
CGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCCTGCCACCACGCCTGGCTAATTTTT
GTATTTTTAGTAGAGATGGGGTTTCACGTGTTAGCCAGGATGGTCTCGATCTCTTGACTCGTGATCCGCC
CTCCTCGGCCTCCCAAAGTGCTGGAATTACAGGCATGAGCCACTGTGCCTGGCCATAATTTTTGTATTTT
TAGTAGAGACAAGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCATGATCCGCCTACCT
CGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCTACTGTGCCCGGCTGGATTCCAATTTTTTATCAGA
TAGGTGTTTTGCAAATATTCCTTACACTCTCTAAGTTGTCTTTTCATTGTTTTAACTGTGCCTTTCAGAA
AGAAAAAGTTTTTAACTTCGATAAAATAGTTTATTCTTTTTTTTTTTTTTTTTTAAATCATGGGTTATGC
TTTTGGTGTCTTATTTCAGAAGTAAGCACTAAACCCAAAATCAGCTAGATCTTCTCCTGTGTATTTTACG
AGTTTTAAAGTTTTGCATTTTATAGTTAGGTCTGTGATTCATTTTGAGGTAATTTGAGTTACTTGTGATC
TTGAGTGTCTTTTGATTTACAGGTTTCCCATTTTCTTTTTTTTTTTTCCCCTCGTAATTGTGGTTTGAAG
AAAGTCCGTTTATGTCCTATTGAGTTTCCCTCAGACTGGATTTTACCCTTTGCATCCTCTGATGTTGCTG
GACATAGTCCTCCTTCTCTTCTTTAAAGGAGCAGCTCGATCTGCAAGCTTGATCAGATTCTGGTTCAGTT
TTTATGGCAAGAAAAGTTTCGGCCGGGCGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGTGGATC
ACAAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAAAATACAAAA
ATTAGCTGGGCGAGGTGGCGGGCGCCTGTAGTCCCAGCTATACTGGAGGCTGAGGCAGGAGAATGGCTTG
AACCCAGGAGGCGGAGCTTGCAGTGAGTGGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGGGCGAG
ACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAACTTTCTGGGTAGTTGGTGGTTATGTCTGTGTG
CATAGGCTGCAAATATCTGCTCGCTTCTGTGCTGTTCTGCGGACCACTGGATTCGGGTGTTACAAAGTTC
TCTGTCAGGTTTTCTCCTGATGCTTTTAGCGGACAGCCATGGCCACTGCCTTAATCTTTTTTATTTATTT
ATTTATTTATTTTTGAGATGGAGTCTTGCTCTGTCGCCCAGGTTGGAGTGCAGTGGTGTGATCTCGGCTC
ACTGCAACCTCTGCCTTCCAGGTTCAGGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGG
CGCATGCCACTATGCCCGGCTAATTTTTGTATTTTTTTGGTAGAGATGGGGTTTCACCATGTTGGTCAGG
CTGGTCTTAAACTCCTGACCTTGTGATCCACCTGCCTCGGCCTCCCAAAATGCTGGGATTACAGGCATCA
GGCATGAGCCAGCGCGCCTGGCCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGAGGGAGTCTGC
CTCTGTCACCAGGCTGGAGTGCAGTGGGCATGATCTCGGTTGACTGCAACCTCCACCCCTCAGGTTCAAG
TGATCCTCCTGCCTCAGCCTCCTTAGTCGCTGGAATTACAGGTGCACACTACCACACCCAGCTACTTTTT
GTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGATGGATTTCTTTTTTTTTAGAGAGATGGAG
TTTCACTCTTATTGCCCAGGCTGTAATACAATGGCATGAACTCGGCTCACTGCAACCTCTGCCTCCTAGA
TTCAAGTAATCCTCCTGCCTCAGCCTCCAGGGTAGCTGGGACTACAGGCATGCGCCACCATGCACAGCTA
ATTTTTATATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCGAAGCTGGTCTTGAACTCCTGACATCAG
GTGATCCGCCTGCCTCAGCCTCGCAGAGTGCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNCACCGCGCCAGCCTTTTTCTTTTTTTTTTTTTTTAGACAGAGTCTTGCTCTGTC
GCCCGGGCTGGAATGCAATGGTGCAACCTCTGCCCACTGCAACCTTCGCATTCCGAGTTCAAGTGGTTCT
CCTGTCTCAGCCTCCTGAGTAACTGGGACTATAGGCGCCTGCCATCATGCCCAGCTAATTTTATGTATTT
TTAGTAGAGATGGGGTTTCACCATATTGGCTAAGCTGGTCTTGAACTCCTCACCTTGTGACCCACCCGCC
TCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCTGGCCCCAAGTTTATAAATTTTAAT
TTATAAAGCTCAATTTTATCTTTGATTCTGTAGCTTTGTTGTGTATTCTCTTTAAGGAATCTTTCCTCCG
AGAAAGGTATTCACCTATGTCTTCTAGAAGCTTAGTTGATGAATAGCTTCCACATTTAGTGATACCATTG
ATTTTGAGTTAATTGCCTGTTATGATGAGGGTAGGAGTTGAGGTTCATATGTCCAGCCAGCATCATTTGT
TGCTAGACCATCATCCCCTCTCCCTCACTGGACTGCAGGGGAGTGTGTTTTGTGTGTAAGGTGTGGATCT
GCTTCTGACCCTCTCCTATTCTGCTGATTATTGGACTTAGTGTCAGTACCTCACTCTTGATTTGATGTAG
CTTTTTTTTTTTTTTTTCTTTTTTGAGATGGAGTCGCACTCTGTCGCCCAGGCTGGAGAGTAGTGGTGTG
ATCTCGGCTTACTGCAAGCTCCGACTCCCGCGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTG
GTACTACAGGCGCCCGCCACCACACCCGGCTCATTTTTTTGTATTTTTAGTAGAGATGGAGTTTCACTGT
GTTAGCCAGGATGGTCTTGATCTCCTGACCTCCTGATCCGCCCACCTTGGCCTCCCAAAATGCTGGGATT
CCAGGTGTGAGCTACTGCACCCATCCTGAATCTATTTTTATGAGAGACATTGGCCTTAAGTTCTCTTTCT
TATAATGTCCTTTGTTGTCAAGATGATGCTGACCTCATAAAATATGCTGGGAGAGTGTTTCCTCTGTTTT
ATTGCCTGAAGAGTTTGCGTAGGAGTAGAATCATTTCTACATTGGAAGAATTCACTAATTGATGTCTTCC
GGACCTGGAATTTTAGTTTTCGGAAAGTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTATGT
CGCCCAGGGGGGGGGGCAGTGGCCGGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTTTTACCCCAT
TCTCCTGCCTCAGCCTCCCGAGTAGCCGGGACTACAGGTGCCCACCACCTCCCCTGGCTAGTTTTTTGTA
TTTTTTAGTAAAAACAGAGTTTCACTGTGTTAGCCAGGATGGTCTCGAACTCCTGACCTCGTGATCCGCC
CGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCTTGAACCACCGCGCCCGGCCAGTTTTCGGAAAGTTT
TAAACTATGGATTAAACATTTTATTTATTTATTTTTTTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNCAGCTACTCGGGAGGCTGAGGCCGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCTG
AGATCCGGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAATA
CTTACAGGACTGCTGACATTTTAAATTTCCTCTTGTGTCAGTTTAGAAGGTTGTATTTATCAAGAATGTG
TTCAGTTCATCTAAATTTTCAAATGTGTTAGTATGGAATTTTTCATAATTATCCTCTATCTTTTTTTTTC
CTTTCCCCAAGACGAAATCTCGCTCTGTCACTCAGGCTGGAGTGCAGTGGCACGATCCCAGCTCACTGCA
ACCTCTGCCTTCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCA
GCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCACGTTGGCCAGTCTGGTCTCAAACTCCTGACC
CCAGGTGATCCACCCACTTTGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCATGCCCAGCCCA
GGGAGGTGACATCTTGAGGGGACACCTTCAGGGTGGATAGGTTCAGTCTCTGTCACCTGGGAAGCGCCTC
CTCTTTTACCACCACATTATCCGGGGTTAGCACATTGCAAACATGGAGGCCTCTTTCTGTCATTACCCAG
CCCTGGCCCTGGGAGTGGTGGGCTCGGGGCTTAGACCTGTCTGCCTGGTTTCCTGCAGAGCCCCCCTCCA
TGCGCCTGAAGGCCCGACCCGGCAACCCTGGCTTTTCCGTGCTTACCTGCAGCGCCTTCTCCTTCTACCC
TCCGGAACTGCAACTGCGGTTCCTGCGGAATGGGATGGCCGCTGGCACCGGACAGGGCGACTTCGGCCCC
AACAGTGACGGCTCCTTCCACGCCTCGTCGTCACTAACAGTCAAAAGTGGCGATGAGCACCACTACTGCT
GCATCGTGCAGCACGCGGGGCTGGCGCAGCCCCTCAGGGTGGAGCTGGGTGAGGCCCCGCCCGGTGGTGA
TGCTCCTGGTTTCCCGTTGCCTTGTCTCACTGCTGCGCCGGTCCTTCCTGAGTCTGACCTTCCTCCCCGC
TGCTGCCATCTCCTTGAATCTGACTGCCTTGTGCCTCGCGCCTTTCAGTGCCCCCAAAGCCTGATGCCTT
GTCCTTCCCAAGGCCGACTGCCTTCCGTCCTGCTGCTTCTGGCCTCACTGAGTCTGAAGAGCTGTTAACC
ACCATGGCCAGTCCTCCCTGAGTCTGACCGTCTTCCATCCTGCTGCTGCTGCGGCTGCAGGTCTTCCTGG
AATCTGACCATTCGTTGTCTGCTATGCCCGTCCTCACCAAGACTGACCACTTGCTGCCTTGCTACTGCTG
GGGCCCATGAGGCTGACTTCCCACTGCTCTGCCTGCCTCTCCCCGCTGCGCCGGGACAGCCCCACCCTGC
CGCTGCTGGTCCATTGCCAGTGTGACCACGGCGGCCGCTCGTGCTGTGGCTGGTTCTTACATCCAGCCTG
GGGGCACCCTGCCGAGATCGCCCGCCTGGCCTTGCCTCTGTCCATCAGACACTTGGTGCTGGGATCTCCA
AGGCTGGGAGGGACTGGGACCCCCCACTGCTGTGTCCTGACTGGGTGGGGGTGGACGGGCTGCTCCACAT
CTCACAGCGTTCTCTGGCTGCAGAAACTCCAGCCAAGTCCTCGGTGCTCGTGGTGGGAATCGTCATCGGT
GTCTTGCTACTCACGGCAGCGGCTGTAGGAGGAGCTCTGTTGTGGAGAAGGATGAGGAGTGGGCTGCCAG
GTGTGGGCAGCGGGAGGAAGAGCCTTGGAGAGAGGGACAGAGACCCCAAGAGAGGGGCACACAGACCTGG
GAGGAGAGACCTGGTGTGGGGACAGACCCAAAGAGAGGAGGACAGAGACCAGAGAGAAGTGGAGACAGAA
ACCCAGAGACGGGGGAACAGAGGCACAGAGAGAGGGGACAGAGGAAGGGGGAGACAGAGACCCCGAGGAG
GGAGGCAAAGATGTAGAAAGAGGGGGGATGGAAAATTGGGAGAAGGGGAGACAGGCCCAGAAGGAAGGGG
TTAGAGACTGAGGGAGTGTGTGTGAGACACACACAGAAATGGGGGATGCCAGTCAGACCCAGAGCACCTC
AGAGATTCTGATGACCTCCCCCTCTCTCTCCACAGCCCCTTGGATCTCCCTCCGTGGAGATGACACCGGG
TCCCTCCTGCCCACCCCGGGGGAGGCCCAGGATGCTGATTCGAAGGATATAAATGTGATCCCAGCCACTG
CCTGACCATCTGCCATTCCGACTGCTAAAAGCGAATGTAGTCAGGCCCCTTTCATGCTGTGAGACCTCCT
GGAACACTGGCATCTCTGAGCCTCCAGAAGGGGTCCTGGGCCCTGTTGTCCTCCCTCTGGAGCCCCGTCC
TGTGGTCTGCCTCAGTTTCCCCTCCTAATACATATGGCTCTTTTCCACCTCGATAATATAACACGAGTTT
GGGCCCGAATCAGTGTGTTCTCATCATTTTTCAGGCAGGGGAGGTAAGGGAATAAATCAGGGGACTGAAT
GGCCGCTGAGGCTCAGATCTCTCCTACAGGTAA
>gi|383873191|ref|NP_001244449.1| Fc fragment of IgG, receptor, transporter, alpha precursor [Macaca mulatta]
MRVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYDSLRGQAEP
CGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELSPDNTSVPTAKFALNGEEF
MNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKAR
PGNPGFSVLTCSAFSFYPPELQLRFLRNGMAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHA
GLAQPLRVELETPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGSLLPTPGEA
QDADSKDINVIPATA
Vaximmutor
IL4
Macaca mulatta
574281
74136371
EGK_16838
CM001258
NP_001028076
9544
6
129082063
129090398
+
interleukin 4
9.44
17265.73
153
>gi|109157119:129082063-129090398 Macaca mulatta chromosome 6, Mmul_051212, whole genome shotgun sequence
AATGGGTCTCACCTCCCAACTGCTTCCCCCTCTGTTCTTCCTGCTAGCATGTGCCGGCAACTTTGCCCAC
GGACACAACTGCCATATCGCCTTACGGGAGATCATCGAAACTCTGAACAGCCTCACAGAGCAGAAGGTGA
GTACCTATCTGGCACCATCTCTCCAGATGTTCTGGTGATGCTGTCAGTATTTCTAGGCCATGAAAACGTT
AACAGTTGCTAGAGAAGTTGGAACTGGTGGTTGGTGGCAGCCCGGGGCACACAGCCAGGCTTCCCCTGTC
ACTCTTTTTTCTGAGGGTTTGTAGGAAGTTTCCTCAGTTGGAGGGAGTGAGAGATGCTCATCAAGGACTG
CTCTGTCCAGTTGGAGGTTAACTCTGTCTCTTGCTCTCTCATTTCTGCCTGGACCAAGACTCTGTGCACC
AAGTTGACCATAACGGACATCCTTGCTGCCTCCAAGGTAAGAAGCCGTCCCACGGTCTGTTTTAGCACAT
GGGGAGATCCATCCCCAAGTGTCTGAATAAGAAACTTGTCTAATGGAAAACAAGCGGGCCCAAATTAACT
CTAAGGTGTTAGATGTTTTCAAAGAACGAGAAGTCTGATTTTTACTCTTAAGTGTGTTTTGGTCTTTCTG
GTTTCACTTGATTTAGATGTGTAATAGAAAGCTTACATGCTATAGTCCTGACTCAGATCCTGGTCAAAGA
AAAGCCCTCTTGGGTTTTACTTAGCTTTGGCATAGTGCCTGGAACGTAGGAGGCACTCAATAAATGCCTG
TTGAATGGGAGAATTTTTCTGGCCCATACATTTCTGAAAAACCAAATACTCTCACAGAAACAGATATTGA
GATGACAGGTTGAGGGAGCTTTCATTTTGTCTAAGAGACTTCCTATGGCAACAGAAAAGGTATCACCAGA
GCCCCTCCTCTTCCACAGCCTGGCCACCTAACAGCCCTCTGGGTTCCAGGGCTGGCGGTCCAGGGCTCCT
CAGCTTGCTCTGGCGGGTCGAATTCCCGTCCAGCTCGGTCCGGAACCATCCTGCTGGGCAGCGTCCAGCA
CATCCCTGCTTCCGGTTGCCTGGGCACCTCGCCTCTCTGCCTCCTGTGCTGCCTCACCCCCACCCCTCTA
TCTGTAGTGGGAGGAGATAGATTTGACAGCTGATAGTGCATTTTCTCTGACAAACACATGACTACAGCCG
TATCAATAGTTTTGTGCATTTCAGTTCCTGTTTTCATGGAAACACACAGCTGAGAATGAAAGCCCCAAAG
CCTCAATTTCACAGTGGTCTCCTAACTACTGCTTTCCATGCGAACTAGGGGGATGATTTGGCCAGCAGTG
AAGCCCTGTGTGTTGGGCAGGGTCACGCCCTGGCACCCAGGCCATAGAACAGGGCCCATCCTGCTTCATG
AGGGAAACTGCTCTTCGGGCCTTTATCTGGACTATCTCATTCATTAAACGTTATCCCAGGAGTTCAATAC
AGGATGAGATTCCTGAAGGGTAAATCCACACTTTGTTTTTTTTTTCTTTTGAGATAGGGTCTTGCTCTGT
CACCCAGGCTAGAGTGCAGTGGTGCGATTTCAGCTCACAGCAGCCTCCACCTCCCAGGCTCAAGCTAACC
TCCCACCTCAGCCTCCCAAGTAACTGGGATGACAGGTCTGCGCCACCACGCCTGGCTAACTTTTGTATTT
TTGTTGTAAAGATGGGGTCTTGCCATTTCATTTTGCCCAGGCTTGTCTTGAACTTCTGAGCTCAAGCAAT
CCATCCACCTCGGCCTCCCAAAGTGCTGGGATTAGCCACTGCACCTGGACAACAGTTTGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTATACACAAAATTTCTAAGTCCTTCCAACCGAGATGGCTCCTACTAGAAGCCA
AGAGTCCACCGGGTTGAGCACTGGGTCTCTGGAGGCCTGTGGCACTGCTGAGAAGGCTCTAACAAAGCCA
AGGGAAGGGCCACCTCACTAGAAGTCAGGCCTGGAGGAAGGGTGAGGGTTGAGGGCCTGGAGGTGAGACT
GCCTATGGTTTTAGACCCCGCTCTGCCACTGACAGCTGTGTGGCTGGCCTTCGGCACATCTTCACACCTC
TCTGCACCTCAGTTTCCACGTGTGAAGATACGAAAGTGATTCTGAAGGTGATTGCAAGGTTGATTGGAAT
CCAGTTCTTGAGTTAGTGGAAAGGGTTATTGTGAGATGATATAACCCTGATTAAAAGCAAGGACACGTTG
CAGAGAAGCGATGATTCTAAGAAGGAGGTGCCCAGGTTGGAAAGGATCAAACCCTCCAGGATGCTGAGCC
TGGGGCTATCCATCTGGGCTGTTTCTGGAAGACCTCCAGGCGCAGGCGAGGACACCACTGCCCTCCCGTC
CTTAACTCCCCTCTTCACTCAGTCCTCACTCACCTCCCTCTCACACACACAGACATCTCCTAGAACAATC
CCCACTGCCTGCCTTTACTCTTACCTGTCTCATTCGCCTTCCCCGAACTTCATCCTCCTGGAGTTCTCAA
TCTCACTCTTCTACTCTTTTCTTCCCCTTGAAGATTCAGCACTGCTTACTTACATGTTAAGATATTTCAG
AACAGTGAAATGTTGCTATTTTCAAAAACCTACAAAGGTGGTATGCAGAGGAAAAGGTACTTCTTTGTGT
TCCCAAAGAAAACATCTTTCCAAAATCCAGCCTATTGATTTTATTTCTTCGGGGGGAACAAGAATTTTAG
TATCTCTAAGTTGGGTAGCATTCTACTCTTGGCAGTTGCTGGAAAGAAGGCACTGATCTAGGTCCTGGGC
TTCATAGGTAACACCTGTTGGGGTGTCTATGAAGTCAAGGCTGTCTGAGGAACAGCAAAGTGGGAAGAAG
CAAGCTGGCTGGTCGATGAAGGGTTTCTTGGGTGGACAAGTAGATGGAGCTATTTCCTACTTACCAAAGA
GAGCTAAAGTTCATAATTCTACAGAGAGTTCCATAATGAACCTCAAATATCTCTGTTTTTTGAAGGAGTT
TCTCATATAGAGCACTAGCTGACTACCCTGGGCAGGATGGGAGATAATGAATGCAGTGCCAGTCGGGCTG
GATTTGTATGGTCCTCAGTGAGGCTGGTCAAGAACCAAGTCAGAACTCTCACAGAGTCACTGCCACAGAA
GAAATCTCCTAAGTGGCTGTTTCCTGACATTCCCGGGAGGGACAGACCTCCTTCTCAGTCACTCCCTAAG
CAGTTCTGAACGGTGAGGTCAGCCAGGCTGTCAAAGTGCACTCCCTGAGCCACTGGCAGACACACTCAGC
AGCCGGAGCTAGACAGGCAGGTAGAAGGAGTCCAGGGTCACAGCAGGGATGGAGTGTCGCCCCCTCGCTG
CGATACCAGAGCAACTAAAACGTAAAGGCCGCACTAAAGCTGCCCTTAGGATGTATTCTTTTAAAGTTTT
TCCATTTAATGCAGACTCTTTTCAATTCTTATTTTATCCTTGTTTCCTTTAGAAAGTCCTTTGAAAAATA
TCTTTAGAGGATTTTTTCCTATACTATGTGGCCATATATGGGTCAAAATTAAGTTTAATTTCCAGGGTCC
AAGCCAGCATTTCAGAAAAATCTCACCAAGGTTTGTGGGAAAAGAAGCAAAGGCTTTTTGGCCTTCTTGA
AGCTCACTGTTCCCTCTGCAGCAGCATGCATGTCTGCCCACCTCCAGACACTCAGGTAGCATGTGCTGCC
CCCCACCAGCCCCTGTGTCCCCTCCACCTCGACTCGCCCACAAAGCACAGAGAGGTCTGTTTCTTGGCTC
CAAGAGCCCAAAAATACTGACACACTCTTGTATTTCCAACTAGAATCAGGAACCAGGAGTGACTCTCAGT
CAGTTCATTAAGTAAATGTCTTTCCAACCGCTCTGCCCATGGGATGTCACGCCCCACAGAGGAAAGGGGA
AGCTTCCGTAGCCTGGGATTCTGGTGCCTCAATCTGGGTCTAGATCTTCCTGAAAAAAAAACGTTAAAAT
ATGAACTGCATTCCTAGAATGTAGCCTATATAAATAAGAGATGAACACAAAGATTTATATAGTTTACTCA
CTGCCACTTATTTACAGAAAGAGAAAGCTGCTGTAAATAAGGCAAATTACAATTGTAAAGGGGCCTGACA
AATGACAGCACCACTATGCAATACGTTTCTATGCAGCTCTCAAACCCATGTTCTCAAATACCACCGAAGG
GCTTAGGAAATGCTTATAGTATATGCAAAGGGTAAAAAAGTTACAAAACAGTATCAACAGTTGATCCCTA
TTTTAAAAAGTGTTTTTTAAAGTGTGATGATATTTACCAAAATATTAACAGCAGTAGTTACCTCTGGCTG
ATGGGATGAGTGAATGTACTTTTGTTGAATATATAATTACCTTTATAGTAAATACACGTTACCTTGATCA
TCAGAAAAAAAAATGTAACCGTAAGAACTTGAAAGCTGCTTGGACAGTGCTGCTGATAGAAATCCCTGAG
GATCTTGTCACTGTTCTGATTCAGAGGGTCTGGGTGGGGCAGGGGTGGTCTGAGATTCTGTATTCTAAGA
AGCTCCCAGTGATGTCCATGATTCTGGTCATGGACCACACTTTTGAGTAGCAAGGGACCAGAGCATGTCG
GGGGAGAGGCTGGGGATAGCTTTATCTCAACTGGATAAAGGAACTAGGCTCAAGCTAAGAACCCTCTCCA
AGTTCTGCATCTTTGTTCTTCAGTGAAAAATGAGAGGACAGACCAGTTCAGACCGAGACAAAATCCCTCT
CCTGGGTTCCCAATGACTTGTCTCCCTGTGTGTCCATTCCCTTCTCTAAGGTTAAGGGCCCCAGGAAGAG
CCATGTGGCCAGACCCTCACAGTTGCCAGCATTTCAGGGAGATTCTCACTCTGCACCATTTGGGGCCAAA
AGGCCCCTTACAGAAACTCTGCCCAACGCTCAGCTCAATGGCACCTGCTCCCAGAGCCTCCCCTGATCTC
CCAGGACACCTTTCCCCAATCTGTACACTTATCTCTTGCTGCCTGGGGTAATGTCTTAGCTCCTCACTTG
GACCATGTGCTGCTCTCCTCTCCCATGGGGAGGACCAAACGGATAGTGCTGCCCAAAGCAGCAGAGTCCA
GGCCAAAGGATGTGCCCTCATTTATTCAACAGGCATGCAGGATTTCCAGGGAAAGCTGGATTTTAAAACC
TTTGGGAACGAGAGCAGAACCTGACTGAGAGCTCATGTGGGCACTGTCCATAGCAGAATAGCTCATGGGG
TATAGAGATACGGACGCGGAACGTGGGCTGTAGCGATAGATAGTCCTGCATTCTAGTCCCCACTGTGCCC
TTTCCTTGCGGGGTGGCTTTATTCAGGTACCCTTTCAGCAAAATCCTCCAAGAGAAAAGAAACTGGGGGG
TTCTGGGGAGAAGGCTGCTGCGTTTGCAATTGGGAGAGGTTGTTGACAGAGGTTTGTGTCTGTGGCAAGC
AGCCTTCCTTCAGTGGAATACTTGAAGACAGGTCTGTAGTTGAGCAAACTCACCTCCATTTGTCCCTCTG
GAAAGAAGAAATCAAGAGGAAAAAATCTCTTTCCCATCCTCCAAATGGAGCTGGCACATGGCTATCTATG
GCATTTGTCTTTCCAGAACACAACTGAGAAGGAAACCTTCTGCAGGGCTGCGACTGTGCTCCGGCAGTTC
TACAGCCACCATGAGAAGGACACTCGCTGCCTGGGTGCGACTGCACAGCAGTTTCACAGGCACAAGCAGC
TGATCCGATTCCTGAAACGGCTCGACAGGAACCTCTGGGGCCTGGCGGGCTTGGTAAGCTGCACTGTATT
CCTAGCAAGCTGGCAGCATGGCTCCTGGTGGACAGCAGCCTCACTTCTAAACACTCCTCCTTAGGAGCTG
CAGCACCCTTGGTCAACCCATTCATTCATTCACTCATTCACTAAGTATTTGTTGAAGTTCCGTAAGTGCT
GGGTGCGGTTCTAGGTGCTGAGGACGTGTCACTAAAGACACGCAGGCCAAGTCCCTGTTCTCGTGGGATG
TTCTAGTGGGAGAGTCAGAAAAACAAACATGTAAAATGATGCCCAGTAGTGATACGTGCTACAAAGAAAA
ACATAGGAATAAAGAATGTAAGGGTCATGGGGGAGGGGGCTGACTTAGGAGCTGGTGACATTATCTGAGC
AGATATTTGAATTAAGTGAGGGAGCAGGCCACATGACTAACTGGGGAGAGACCATTCCAGGCAGAAGGAG
GAGCTATGCAAAGGCCTTAGGATGGAAATGAACTTCCTGTATTTGAAGACCAGTAGGAAGGCCAGTGTGG
CTGGATCACAGTGAGTGAGGGGGAGTTTCTAGGACAGCAGATCACACAAGGCCTTGAGATTCCACCACGA
GTATGGCAGGGAACACCTGCAGAGCTCTGGGCAGGGCAAAGACTGTACGATCTGATTTACGTGATTTAAA
AGGGTCAGTCTGGCTACTGTGTGGTAAATAGGCTGAAAGGGGGAGGCATAGAAGCAAGATGGCCTGTTGG
GAGGCAGTAAACCAGGCTAGAGATGATGGTGGCATGGACAGGATGGGAACAGTGGATAGATTTGGGATAT
GACTAAAAATAAAACCAGAAAGATTTGCTGACAGATCAGTTGTAAGGGGTAAGATACAGGGGAGGAAAAG
ATGACCTCTTCGTTCCTGCCTAAACCCGTCTGGCGATGGTTGGTACCGTTTATAGAGCGATGGAAGACTG
GGGGCAAGGCAGGGCTGGAGGTTAAGCAGAAGATCAAGAGTTCAATTTTGTACGTTGTACATGTAAGGTG
GCTGTTGGACAGCCAAGTGAAGATGTTGAGAAGATGGTTAGAAGAGTCTGGAACTTAGAGGAGAGGTCAG
AACTTGCAGTACAAAAAGGAGAGTCCTTAGATAGATGCTATTGAAAGTCTGAATGACAGAAAGGGAGAGA
TCAAAGGACTGAGCCTGAGATCAACACATGGAGGTCAGGAGAGGAGGATCCAGTAAAGGCGCCTGAGACT
CCTCAGACCAGTGAGGCAGGAGAACACTGGAGAGTGGGCGGTATCCCAGGAGGCCAGTGAGGACACTCAC
GGAGGGAGGGTCGACTGTTTCAAATGTACTGAAAGGTCAGGTCAGGTAAGGACTGAGAAAGGCCCCTGGG
TTTGACTGATGGAGGTCATGGGTGAGGCTGATGTAAATGGAGAAGCAGGAAGGAAAGTCCAGCTGGAGTG
GGCTCACCGAGGATGGGGCGGTGAGAGAAGCCAAAGAAGGAACAGTGAGGGCAGAACACTCTTTGAAGGT
GTTTAGCTATAAGGCTGCAGAGAAACTGAACCATGGCTGCAGGGCGGTTATGGAGTGAGGGAAGCTCTTT
TAAGGTGGGGTGTATACCCAGCATGCTAATGCACCTGGGGGAACGGTCTGGTGGAGTAGGGAGAACTGAA
GAGAGGAGAAGGAGGAGGAATCATTAGAGGGCAGAAGTCCTTGTGGCCCAGAGTGGGTGTTATCTAATAT
CGAGTGGAGGAATTAATTGGCTTTAGAAGAGAACAAGGACATGTATCCCTTCTTTGGGCCTATCACCTTG
TAGACAATGGGATAGGTCATGGGATAGGAACTTGGCACAACACATGTTCTCTTTTAATTCTCTCCATTAT
CTTATGAAGCAGGCAAGTAGGCAAACAATTGTCCCGACTTTAAAAATAAACTGAAGCTTTTATAAATTAA
GTAGTACGTTCTCAGCAATACAATTAATAAATGGTAGAGCTGAGATTCAAACTGAAGCAGTGGCCTGGGG
GTAGCATCTGGAACCCTTCCCACCTTTAGGGCTGCTGTGCTGCAGTGCTGCTGTTTAATGACAGGAGGGC
CACATGACTGAATCTCTCTCAGCAGTCCAGGCAGCCATGCAGAAGGCCCAGTAGAGCACGGGCAGGTCTG
AGCCAGCACCTTCAAGTTCTACCCTCTGAGCAAGCACCTAGCTGTGACACACCTCTCCAGAGACTGCACT
CCCCGCCGCCCTGCCCACCGCAAAAGCAGATAGGTAATGGTATACAGTAACCATTTCTAGAAGTGTAAGT
AGTATGCACCCAAAACAGGCAACACCTGCTGGCCTAGTGATAGAGACGACTCCCAGTCAGGCTAGACTGG
AGGCCTTGGTTTGGTAAGTGTTCAGGTGGCAAGTACCAGAGTAGGCTTGATCAAGTAGACAGGCAGGCAA
GACAAATGCTTACCAATGCAAGCTAATTAAATGCTTCTTTTGTAGAACTCCTGTCCTGTGAAGGAAGCCA
GCCAGAGTACGTTGGAAGACTTCTTGGAAAGGCTAAAGACGATCATGAAAGAGAAATATTCAAAGTGTCG
GAGCTG
>gi|74136371|ref|NP_001028076.1| interleukin-4 precursor [Macaca mulatta]
MGLTSQLLPPLFFLLACAGNFAHGHNCHIALREIIETLNSLTEQKTLCTKLTITDILAASKNTTEKETFC
RAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEASQSTLEDFLERL
KTIMKEKYSKCRS
Vaximmutor
Nef
Human immunodeficiency virus 1
VO_0011261
156110
28872818
HIV1gp9
AF033819
NP_057857
11676
8342
8962
+
Nef
6.42
22179.3
206
This particular nucleotide sequence has a premature stop codon in place of a well-conserved tryptophan codon at position 8712-8714 that truncates the HIV1 Nef protein sequence to a 123 amino acids-long N-terminal portion (not shown).
>NC_001802.1:8342-8962 Human immunodeficiency virus 1, complete genome
GATGGGTGGCAAGTGGTCAAAAAGTAGTGTGATTGGATGGCCTACTGTAAGGGAAAGAATGAGACGAGCT
GAGCCAGCAGCAGATAGGGTGGGAGCAGCATCTCGAGACCTGGAAAAACATGGAGCAATCACAAGTAGCA
ATACAGCAGCTACCAATGCTGCTTGTGCCTGGCTAGAAGCACAAGAGGAGGAGGAGGTGGGTTTTCCAGT
CACACCTCAGGTACCTTTAAGACCAATGACTTACAAGGCAGCTGTAGATCTTAGCCACTTTTTAAAAGAA
AAGGGGGGACTGGAAGGGCTAATTCACTCCCAAAGAAGACAAGATATCCTTGATCTGTGGATCTACCACA
CACAAGGCTACTTCCCTGATTAGCAGAACTACACACCAGGGCCAGGGGTCAGATATCCACTGACCTTTGG
ATGGTGCTACAAGCTAGTACCAGTTGAGCCAGATAAGATAGAAGAGGCCAATAAAGGAGAGAACACCAGC
TTGTTACACCCTGTGAGCCTGCATGGGATGGATGACCCGGAGAGAGAAGTGTTAGAGTGGAGGTTTGACA
GCCGCCTAGCATTTCATCACGTGGCCCGAGAGCTGCATCCGGAGTACTTCAAGAACTGCTG
>NP_057857.2 Nef [Human immunodeficiency virus 1]
MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPV
TPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFG
WCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC
Protective antigen
Study compared the handling of overlapping 24-mer peptides from HIV Nef either mixed or covalently linked in tandem in one protein. With adjuvant, overlapping peptides were capable of protecting Balb/c mice against lethal viral challenge with 3 × 108 plaque forming units of vv-nef, whereas the intact protein was less protective [Ref1296:Zhang et al., 2009].
nef
Human immunodeficiency virus 2
1845210
CDD:249884
11709
?
nef protein
6.88
28422.79
319
similar to HIV2BEN, GenBank Accession Number M30502, and to HIV2D194, GenBank Accession Number J04542
>AAB47785.1 nef protein [Human immunodeficiency virus 2]
MGASGSKKLSKQSQGLRERLLRARGGGYVRQCSASGGESSQSQGGSGREQKSPSCEGQQYRQGDYMNTPW
RTPAMEGQKESYKQQNMDDVDSDDNDQVGVSVTSRVPLRPMTYKLAVDMSHFIKEKGGLEGMFYSRDRHR
ILDLYLEKEEGVIPDWQNYTHGPGVRYPMCFGWLWKLVPVNMSQEAEDDETNCLMHPAQTSRYDDIHGET
LVWRFNSMLAYEYKAFTLYPEEFGHKSGLPEKEWKAKLKARGIPYSE
Protective antigen
Nef SIV
Simian immunodeficiency virus
1490008
9627209
SIVgp7
M66437
NP_054373
11723
8599
9270
?
nef protein
6.4
24504.09
223
>gi|9627204:8599-9270 Simian immunodeficiency virus, complete genome
TATGGGCTCCAGCAACTCCAAGAGGCAGCAACAGGGCTTGCTCAAGCTCTGGCGAGGGCTGCGAGGGAAG
CCTGGGGCAGACTGGGTGCTATTGTCCGATCCGCTTATCGGGCAGTCATCAACAGTCCAAGAAGAGTGCG
GCAAGGCCTTGAAAAAGTCCTGGGGTAAAGGTAAAATGACTCCAGACGGCCGCCGCCTGCAAGAAGGAGA
CACCTTTGATGAGTGGGATGATGATGAAGAAGAAGTAGGCTTCCCTGTGCAACCTCGAGTCCCCTTAAGA
CAGATGACCTATAAATTAGCAGTGGACTTTTCCCACTTTTTAAAATCAAAGGGGGGACTGGATGGGATAT
ATTACTCTGAAAGAAGAGAAAAGATCCTGAATTTGTATGCCTTGAACGAGTGGGGAATAATAGATGATTG
GCAAGCTTACTCACCAGGCCCGGGGATAAGGTACCCGAGAGTCTTTGGCTTCTGCTTTAAGCTAGTCCCA
GTGGACCTGCATGAGGAGGCACGCAACTGTGAGAGACACTGTCTGATGCATCCAGCACAGATGGGGGAAG
ATCCTGATGGAATAGATCATGGAGAAGTCTTGGTCTGGAAGTTTGACCCGAAGTTGGCGGTGGAGTACCG
CCCGGACATGTTTAAGGACATGCACGAACATGCAAAGCGCTA
>gi|9627209|ref|NP_054373.1| nef protein [Simian immunodeficiency virus]
MGSSNSKRQQQGLLKLWRGLRGKPGADWVLLSDPLIGQSSTVQEECGKALKKSWGKGKMTPDGRRLQEGD
TFDEWDDDEEEVGFPVQPRVPLRQMTYKLAVDFSHFLKSKGGLDGIYYSERREKILNLYALNEWGIIDDW
QAYSPGPGIRYPRVFGFCFKLVPVDLHEEARNCERHCLMHPAQMGEDPDGIDHGEVLVWKFDPKLAVEYR
PDMFKDMHEHAKR
Other
pol
Human immunodeficiency virus 1
7021456
CDD:278505
CDD:133149
CDD:238823
CDD:278506
CDD:284283
CDD:284281
CDD:278503
CDD:259998
CDD:280240
CDD:279057
11676
?
pol
7.77
90126.73
918
long-term nonprogressor
>AAF35355.1 pol, partial [Human immunodeficiency virus 1]
FFREDLAFPQGKAREFPSEQTRAISPARRELQVWGRDNNSLSEAGANRQGTVSFSFPQITLWQRPLVAIK
IGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQVAIEICGHKAIGTVLIGPTPVNI
IGRNLLTQIGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENP
YNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFR
KYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEI
GQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLN
WASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAELELAENREILKEPVHGVYYDPAKDLIAEIQKQGQG
QWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKVAIESIVIWGKTPKFKLPIQKETWEAWWTEY
WQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTDTTNQ
KTELQAIHLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGN
EQVDKLVSAGIRKVLFLDGIDKAQEEHEKYHSNWRAMAGDFNLPPVVAKEIVACCDKCQLKGEAMHGQVD
CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSNT
VKAACW
Protective antigen
pol
Simian-Human immunodeficiency virus strain SHIV-89.6
2828038
CDD:133149
CDD:295487
CDD:278506
CDD:238185
CDD:284283
CDD:284281
CDD:278503
CDD:259998
CDD:280240
CDD:279057
CDD:278951
57667
?
pol
7.9
113326.45
1139
Retropepsins, pepsin-like aspartate proteases; cd05482
>AAB99959.1 pol, partial [Simian-Human immunodeficiency virus]
LELWERGTLCKAMQSPKKTGMLEMWKNGPCYGQMPRQTGGFFRPWSMGKEAPQFPHGSSASGADANCSPR
GPSCGSAKELHAVGQAAERKAERKQREALQGGDRGFAAPQFSLWRRPVVTAHIEGQPVEVLLDTGADDSI
VTGIELGPHYTPKIVGGIGGFINTKEYKNVEIEVLGKRIKGTIMTGDTPINIFGRNLLTALGMSLNFPIA
KVEPVKVALKPGKDGPKLKQWPLSKEKIVALREICEKMEKDGQLEEAPPTNPYNTPTFAIKKKDKNKWRM
LIDFRELNRVTQDFTEVQLGIPHPAGLAKRKRITVLDIGDAYFSIPLDEEFRQYTAFTLPSVNNAEPGKR
YIYKVLPQGWKGSPAIFQYTMRHVLEPFRKANPDVTLVQYMDDILIASDRTDLEHDRVVLQSKELLNSIG
FSTPEEKFQKDPPFQWMGYELWPTKWKLQKIELPQRETWTVNDIQKLVGVLNWAAQIYPGIKTKHLCRLI
RGKMTLTEEVQWTEMAEAEYEENKIILSQEQEGCYYQEGKPLEATVIKSQDNQWSYKIHQEDKILKVGKF
AKIKNTHTNGVRLLAHVIQKIGKEAIVIWGQVPKFHLPVEKDVWEQWWTDYWQVTWIPEWDFISTPPLVR
LVFNLVKDPIEGEETYYTDGSCNKQSKEGKAGYITDRGKDKVKVLEQTTNQQAELEAFLMALTDSGPKAN
IIVDSQYVMGIITGCPTESESRLVNQIIEEMIKKSEIYVAWVPAHKGIGGNQEIDHLVSQGIRQVLFLEK
IEPAQEEHDKYHSNVKELVFKFGLPRIVARQIVDTCDKCHQKGEAIHGQANSDLGTWQMDCTHLEGKIII
VAVHVASGFIEAEVIPQETGRQTALFLLKLAGRWPITHLHTDNGANFASQEVKMVAWWAGIEHTFGVPYN
PQSQGVVEAMNHHLKNQIDRIREQANSVETIVLMAVHCMNFKRRGGIGDMTPAERLINMITTEQEIQFQQ
SKNSKFKNFRVYYREGRDQLWKGPGELLWKGEGAVILKVGTDIKVVPRRKAKIIKDYGGGKEVDSSSHME
DTGEAREVA
Protective antigen
Pol SIV
Simian immunodeficiency virus SIV-mnd 2
956107
27311168
Siv2gp2
AF367411
NP_758887
159122
2049
5081
+
pol protein
7.91
106929.88
1010
>gi|27311166:2049-5081 Simian immunodeficiency virus SIV-mnd 2, complete genome
ATTTTTTAGGGAATACCCCCTGGGGCAGTGGCAAACCCAGGAACTTCCCGGCGATGCCATTGACCCCAAC
GGCCCCTCCAATGCCAGGGATGGAAGACCCAGCAGAGAGAATGCTGTTAGATTACATGAAGAAAGGGCAA
CAGCAGAAAGCGGAAAGCAAACAGGAAAAGAAAGAGAGGGGTCCATACGAGGCAGCTTACAACTCCCTCA
GTTCTCTCTTTGGAACAGACCAACTACAGTAGTAGAGATAGAAGGGCAAAAAGTGGAGGCCTTACTGGAC
ACAGGAGCTGATGATACAGTAATCAAAGATCTAGATTTAAAAGGTAATTGGAAACCACAGATTATTGGAG
GAATTGGAGGATCAATCAATGTAAAACAGTTTTTCAATTGTAAAGTAACAATAGCAGGCAAAACTACACA
CGCTTCAGTCCTAGTGGGCCCCACACCTGTAAATATTGTAGGTAGAAATGTGCTGAAGAAATTAGGATGT
ACACTAAATTTTCCAGTTAGTAAAGTAGAAACAGTAAAGGTAACACTAAAACCAGGAACTGACGGACCTA
AAATAAAACAATGGCCATTGTCTAAGGAAAAGATTTTAGCCTTACAAGAAATATGTAGTCAAATGGAGAA
GGAAGGCCAGATCTCTAAGATAGGTCCAGAAAATCCTTACAACACACCGGTGTTTTGCATCAAAAAGAAA
GATGGAACCAGCTGGAGAAAATTGGTAGATTTTAGACAGTTAAACAAAGTAACTCAGGACTTCTTTGAGG
TGCAGTTGGGAATCCCACACCCTGGAGGTCTCAAACAATGTGAGCAAATTACAGTACTGGACATAGGGGA
TGCCTATTTCTCATGTCCTTTGGATGAGGACTTTAGAAAGTACACTGCATTCACCATTCCATCGGTGAAT
AATCAGGGCCCAGGAATCAGGTACCAGTATAATGTCCTACCACAGGGATGGAAGGGCTCCCCAGCCATTT
TCCAGGCAACAGCAGATAAAATCTTACAGCCCTTCAGAGAGAGACATCCAGATGTAGTGATCTATCAATA
TATGGATGATCTCTTTGTTGGGAGTGATAGAGTTGCCCCAGAACACAGCAGAATGATTCAAGAGTTAAGA
GACCACCTCTTGTTTTGGGGGCTCGAGACCCCAGACAAGAAGTTTCAAAAGGAACCACCCTTTGAGTGGA
TGGGATACATACTGCACCCTAAGAAATGGACAGTGCAGAAAGTACAGCTTCCAGAGAAAGAAGAATGGAC
AGTAAATGACATCCAAAAGTTGGTAGGGAAACTTAATTGGGCAAGTCAGATTTATTCCGGAATTAAAACA
AAAGAGCTCTGTAGACTAATTAGAGGGGCAAAACCCCTAGATGAAAAAGTAGAATGGACTAGAGAAGCAG
AATTAGAATATGAAGAAAACAAACTCATAGTGCAGGAGGAAGTGCATGGAGTATACTATCAACCAGAGAA
GCCTTTAATGGCAAAGGTTCAAAAATTGACACAAGGGCAATGGAGTTACCAAATAGAGCAGGAGGATAAT
AAGCCGCTGAAGGTAGGGAAATATGCCAGAACAAAGAATGCTCATACAAATGAGCTTAGAGTGCTTGCAG
GACTAGTACAGAAGATTGCAAAAGAAGCTTTAGTGATCTGGGGAAAACTCCCTAAGTTTTATCTGCCAAT
AGAAAGAGAAGTCTGGGACCAGTGGTGGCCAGAATATTGGCAAGCCACATGGATTCCCGAATGGGAATTT
GTATCCACTCCACACCTTATCGGGTTGTGGTATAACCTGTTGAGAGAACCTGTGCCAGGAGAAGATGTGT
ATTATGTGGATGGAGCAGCTAACAGAAACTCCAAAGAAGGGAAAGCAGGATATGTAACAGCTAGAAATAA
ATCCAGAGTAATAGCCCTAGAGAATACCACAAACCAAAAAGCAGAATTGGAGGCAATAAAAATGGCATTA
CAAGACTCAGGACCAAAAGTAAATATAGTGACAGATTCACAGTATGCTATGGGTATCCTATCGGCAGCAC
CCGACCAATCAGACAACCCCATAGTAAGAGAAATTATAGAACTCATGATCCACAAGGAAGCAGTATACCT
AGCTTGGGTACCAGCACACAAAGGCATAGGAGGGAATGAGCAAGTAGATAAACTAGTGAGCAGAGGAGTA
AGGCAAGTACTGTTTTTAGAAGGCATAGATAAAGCACAAGAAGAGCATGATAAATATCACAATAATTGGA
GGGCATTAGCACAAGACTTCTGTATACCAAACATAGTGGCAAAAGAAATAGTAGCCCAGTGTCCAAAGTG
TCAAACAAAAGGAGAGCCAATACATGGCCAGGTAGATACATCCCCAGGAACCTGGCAAATGGACTGCACA
CATATGGAAGGAAAAGTAATCATAGCAGCAGTCCATGTAGCAAGTAGGTATCTAGAAGCAGAAGTAATAC
CCACAGAAACAGGAAAAGAAACAGCACACTTCCTGTTAAAATTAGCAGGTAGATGGCCAGTAAAACATCT
ACACACAGATAATGGCCCTAATTTCACCAGTGAAAAAGTAGCCACAGTCTGTTGGTGGGCTCAAATAGAG
CACACTACAGGAATTCCCTACAATCCTCAGAGTCAAGGAGTAATAGAGGCAAAAAACCATCATCTCAAAC
AAATCATAGGGCAAGTTAGAGACCAAGCAGAGAAACTAGAAACAGCAGTTCAAATGGCAGTATTAATTCA
CAATTTTAAAAGAAAAGGGGGGATAGGGGAATACAGTCCAGGAGAAAGAATAGTAGACATTATAGCAACA
GACCTCCTAACAACTAAATTACAACACAATATTCAAAAAATTCAAAATTTTCGGGTTTATTACAGAGAAG
GAAGGGACCAACAGTGGAAAGGACCAGCAGAACTCATTTGGAAAGGAGAAGGAGCGGTGGTAATCAAAGA
GGGGACAGACTTGAAGGTAGTACCAAGGAGAAAAGCAAAAATCATCAGAGATTATGGAAAAACAGTGGAT
AGTGATCCCAACGTGGAAGCTTG
>gi|27311168|ref|NP_758887.1| pol protein [Simian immunodeficiency virus SIV-mnd 2]
FFREYPLGQWQTQELPGDAIDPNGPSNARDGRPSRENAVRLHEERATAESGKQTGKEREGSIRGSLQLPQ
FSLWNRPTTVVEIEGQKVEALLDTGADDTVIKDLDLKGNWKPQIIGGIGGSINVKQFFNCKVTIAGKTTH
ASVLVGPTPVNIVGRNVLKKLGCTLNFPVSKVETVKVTLKPGTDGPKIKQWPLSKEKILALQEICSQMEK
EGQISKIGPENPYNTPVFCIKKKDGTSWRKLVDFRQLNKVTQDFFEVQLGIPHPGGLKQCEQITVLDIGD
AYFSCPLDEDFRKYTAFTIPSVNNQGPGIRYQYNVLPQGWKGSPAIFQATADKILQPFRERHPDVVIYQY
MDDLFVGSDRVAPEHSRMIQELRDHLLFWGLETPDKKFQKEPPFEWMGYILHPKKWTVQKVQLPEKEEWT
VNDIQKLVGKLNWASQIYSGIKTKELCRLIRGAKPLDEKVEWTREAELEYEENKLIVQEEVHGVYYQPEK
PLMAKVQKLTQGQWSYQIEQEDNKPLKVGKYARTKNAHTNELRVLAGLVQKIAKEALVIWGKLPKFYLPI
EREVWDQWWPEYWQATWIPEWEFVSTPHLIGLWYNLLREPVPGEDVYYVDGAANRNSKEGKAGYVTARNK
SRVIALENTTNQKAELEAIKMALQDSGPKVNIVTDSQYAMGILSAAPDQSDNPIVREIIELMIHKEAVYL
AWVPAHKGIGGNEQVDKLVSRGVRQVLFLEGIDKAQEEHDKYHNNWRALAQDFCIPNIVAKEIVAQCPKC
QTKGEPIHGQVDTSPGTWQMDCTHMEGKVIIAAVHVASRYLEAEVIPTETGKETAHFLLKLAGRWPVKHL
HTDNGPNFTSEKVATVCWWAQIEHTTGIPYNPQSQGVIEAKNHHLKQIIGQVRDQAEKLETAVQMAVLIH
NFKRKGGIGEYSPGERIVDIIATDLLTTKLQHNIQKIQNFRVYYREGRDQQWKGPAELIWKGEGAVVIKE
GTDLKVVPRRKAKIIRDYGKTVDSDPNVEA
Other
rev
Simian-Human immunodeficiency virus strain SHIV-89.6
2828043
CDD:278833
57667
?
rev
9.94
12952.65
173
REV protein (anti-repression trans-activator protein); pfam00424
>AAB99964.1 rev [Simian-Human immunodeficiency virus]
MAGRSGDSDEELIRTVRLIKLLYQSNPPPSLEGTRQARRNRRRRWRERQRQIRSISERILGTYLGRSAEP
VPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTVLESGTKE
Protective antigen
rev from HIV 1
Human immunodeficiency virus 1
155908
9629359
HIV1gp6
AF033819
NP_057854
11676
5515
8198
+
Rev
9.36
12578.23
116
>NC_001802.1:5515-8198 Human immunodeficiency virus 1, complete genome
TATGGCAGGAAGAAGCGGAGACAGCGACGAAGAGCTCATCAGAACAGTCAGACTCATCAAGCTTCTCTAT
CAAAGCAGTAAGTAGTACATGTAATGCAACCTATACCAATAGTAGCAATAGTAGCATTAGTAGTAGCAAT
AATAATAGCAATAGTTGTGTGGTCCATAGTAATCATAGAATATAGGAAAATATTAAGACAAAGAAAAATA
GACAGGTTAATTGATAGACTAATAGAAAGAGCAGAAGACAGTGGCAATGAGAGTGAAGGAGAAATATCAG
CACTTGTGGAGATGGGGGTGGAGATGGGGCACCATGCTCCTTGGGATGTTGATGATCTGTAGTGCTACAG
AAAAATTGTGGGTCACAGTCTATTATGGGGTACCTGTGTGGAAGGAAGCAACCACCACTCTATTTTGTGC
ATCAGATGCTAAAGCATATGATACAGAGGTACATAATGTTTGGGCCACACATGCCTGTGTACCCACAGAC
CCCAACCCACAAGAAGTAGTATTGGTAAATGTGACAGAAAATTTTAACATGTGGAAAAATGACATGGTAG
AACAGATGCATGAGGATATAATCAGTTTATGGGATCAAAGCCTAAAGCCATGTGTAAAATTAACCCCACT
CTGTGTTAGTTTAAAGTGCACTGATTTGAAGAATGATACTAATACCAATAGTAGTAGCGGGAGAATGATA
ATGGAGAAAGGAGAGATAAAAAACTGCTCTTTCAATATCAGCACAAGCATAAGAGGTAAGGTGCAGAAAG
AATATGCATTTTTTTATAAACTTGATATAATACCAATAGATAATGATACTACCAGCTATAAGTTGACAAG
TTGTAACACCTCAGTCATTACACAGGCCTGTCCAAAGGTATCCTTTGAGCCAATTCCCATACATTATTGT
GCCCCGGCTGGTTTTGCGATTCTAAAATGTAATAATAAGACGTTCAATGGAACAGGACCATGTACAAATG
TCAGCACAGTACAATGTACACATGGAATTAGGCCAGTAGTATCAACTCAACTGCTGTTAAATGGCAGTCT
AGCAGAAGAAGAGGTAGTAATTAGATCTGTCAATTTCACGGACAATGCTAAAACCATAATAGTACAGCTG
AACACATCTGTAGAAATTAATTGTACAAGACCCAACAACAATACAAGAAAAAGAATCCGTATCCAGAGAG
GACCAGGGAGAGCATTTGTTACAATAGGAAAAATAGGAAATATGAGACAAGCACATTGTAACATTAGTAG
AGCAAAATGGAATAACACTTTAAAACAGATAGCTAGCAAATTAAGAGAACAATTTGGAAATAATAAAACA
ATAATCTTTAAGCAATCCTCAGGAGGGGACCCAGAAATTGTAACGCACAGTTTTAATTGTGGAGGGGAAT
TTTTCTACTGTAATTCAACACAACTGTTTAATAGTACTTGGTTTAATAGTACTTGGAGTACTGAAGGGTC
AAATAACACTGAAGGAAGTGACACAATCACCCTCCCATGCAGAATAAAACAAATTATAAACATGTGGCAG
AAAGTAGGAAAAGCAATGTATGCCCCTCCCATCAGTGGACAAATTAGATGTTCATCAAATATTACAGGGC
TGCTATTAACAAGAGATGGTGGTAATAGCAACAATGAGTCCGAGATCTTCAGACCTGGAGGAGGAGATAT
GAGGGACAATTGGAGAAGTGAATTATATAAATATAAAGTAGTAAAAATTGAACCATTAGGAGTAGCACCC
ACCAAGGCAAAGAGAAGAGTGGTGCAGAGAGAAAAAAGAGCAGTGGGAATAGGAGCTTTGTTCCTTGGGT
TCTTGGGAGCAGCAGGAAGCACTATGGGCGCAGCCTCAATGACGCTGACGGTACAGGCCAGACAATTATT
GTCTGGTATAGTGCAGCAGCAGAACAATTTGCTGAGGGCTATTGAGGCGCAACAGCATCTGTTGCAACTC
ACAGTCTGGGGCATCAAGCAGCTCCAGGCAAGAATCCTGGCTGTGGAAAGATACCTAAAGGATCAACAGC
TCCTGGGGATTTGGGGTTGCTCTGGAAAACTCATTTGCACCACTGCTGTGCCTTGGAATGCTAGTTGGAG
TAATAAATCTCTGGAACAGATTTGGAATCACACGACCTGGATGGAGTGGGACAGAGAAATTAACAATTAC
ACAAGCTTAATACACTCCTTAATTGAAGAATCGCAAAACCAGCAAGAAAAGAATGAACAAGAATTATTGG
AATTAGATAAATGGGCAAGTTTGTGGAATTGGTTTAACATAACAAATTGGCTGTGGTATATAAAATTATT
CATAATGATAGTAGGAGGCTTGGTAGGTTTAAGAATAGTTTTTGCTGTACTTTCTATAGTGAATAGAGTT
AGGCAGGGATATTCACCATTATCGTTTCAGACCCACCTCCCAACCCCGAGGGGACCCGACAGGCCCGAAG
GAATAGAAGAAGAAGGTGGAGAGAGAGACAGAGACAGATCCATTCGATTAGTGAACGGATCCTTGGCACT
TATCTGGGACGATCTGCGGAGCCTGTGCCTCTTCAGCTACCACCGCTTGAGAGACTTACTCTTGATTGTA
ACGAGGATTGTGGAACTTCTGGGACGCAGGGGGTGGGAAGCCCTCAAATATTGGTGGAATCTCCTACAGT
ATTGGAGTCAGGAACTAAAGAATA
>NP_057854.1 Rev [Human immunodeficiency virus 1]
MAGRSGDSDEELIRTVRLIKLLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILGTYLGRSAEP
VPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTVLESGTKE
Protective antigen
rev MN isolate
Human immunodeficiency virus 1 MN
3511264
CDD:189539
11676
?
rev protein
116
neutralization phenotype variant molecular clone
>gi|3511264|gb|AAC33786.1| rev protein [Human immunodeficiency virus 1]
MAGRNGDSDEELLKTVRLIKFLHQSNPPPSSEGTRQARRNRRRRWRERQRHIRSISAWILSNYLGRPAEP
VPPQLPPLERLTLDCSEDCGTSGTQGVGSPQILVESPTVLESGTKE
Other
Tat
Human immunodeficiency virus 1
VO_0011262
155871
9629358
HIV1gp5
AF033819
NP_057853
11676
5376
7969
+
Tat
10.43
9638.3
86
the length of Tat varies depending on virus strain or clade
>NC_001802.1:5376-7969 Human immunodeficiency virus 1, complete genome
AATGGAGCCAGTAGATCCTAGACTAGAGCCCTGGAAGCATCCAGGAAGTCAGCCTAAAACTGCTTGTACC
AATTGCTATTGTAAAAAGTGTTGCTTTCATTGCCAAGTTTGTTTCATAACAAAAGCCTTAGGCATCTCCT
ATGGCAGGAAGAAGCGGAGACAGCGACGAAGAGCTCATCAGAACAGTCAGACTCATCAAGCTTCTCTATC
AAAGCAGTAAGTAGTACATGTAATGCAACCTATACCAATAGTAGCAATAGTAGCATTAGTAGTAGCAATA
ATAATAGCAATAGTTGTGTGGTCCATAGTAATCATAGAATATAGGAAAATATTAAGACAAAGAAAAATAG
ACAGGTTAATTGATAGACTAATAGAAAGAGCAGAAGACAGTGGCAATGAGAGTGAAGGAGAAATATCAGC
ACTTGTGGAGATGGGGGTGGAGATGGGGCACCATGCTCCTTGGGATGTTGATGATCTGTAGTGCTACAGA
AAAATTGTGGGTCACAGTCTATTATGGGGTACCTGTGTGGAAGGAAGCAACCACCACTCTATTTTGTGCA
TCAGATGCTAAAGCATATGATACAGAGGTACATAATGTTTGGGCCACACATGCCTGTGTACCCACAGACC
CCAACCCACAAGAAGTAGTATTGGTAAATGTGACAGAAAATTTTAACATGTGGAAAAATGACATGGTAGA
ACAGATGCATGAGGATATAATCAGTTTATGGGATCAAAGCCTAAAGCCATGTGTAAAATTAACCCCACTC
TGTGTTAGTTTAAAGTGCACTGATTTGAAGAATGATACTAATACCAATAGTAGTAGCGGGAGAATGATAA
TGGAGAAAGGAGAGATAAAAAACTGCTCTTTCAATATCAGCACAAGCATAAGAGGTAAGGTGCAGAAAGA
ATATGCATTTTTTTATAAACTTGATATAATACCAATAGATAATGATACTACCAGCTATAAGTTGACAAGT
TGTAACACCTCAGTCATTACACAGGCCTGTCCAAAGGTATCCTTTGAGCCAATTCCCATACATTATTGTG
CCCCGGCTGGTTTTGCGATTCTAAAATGTAATAATAAGACGTTCAATGGAACAGGACCATGTACAAATGT
CAGCACAGTACAATGTACACATGGAATTAGGCCAGTAGTATCAACTCAACTGCTGTTAAATGGCAGTCTA
GCAGAAGAAGAGGTAGTAATTAGATCTGTCAATTTCACGGACAATGCTAAAACCATAATAGTACAGCTGA
ACACATCTGTAGAAATTAATTGTACAAGACCCAACAACAATACAAGAAAAAGAATCCGTATCCAGAGAGG
ACCAGGGAGAGCATTTGTTACAATAGGAAAAATAGGAAATATGAGACAAGCACATTGTAACATTAGTAGA
GCAAAATGGAATAACACTTTAAAACAGATAGCTAGCAAATTAAGAGAACAATTTGGAAATAATAAAACAA
TAATCTTTAAGCAATCCTCAGGAGGGGACCCAGAAATTGTAACGCACAGTTTTAATTGTGGAGGGGAATT
TTTCTACTGTAATTCAACACAACTGTTTAATAGTACTTGGTTTAATAGTACTTGGAGTACTGAAGGGTCA
AATAACACTGAAGGAAGTGACACAATCACCCTCCCATGCAGAATAAAACAAATTATAAACATGTGGCAGA
AAGTAGGAAAAGCAATGTATGCCCCTCCCATCAGTGGACAAATTAGATGTTCATCAAATATTACAGGGCT
GCTATTAACAAGAGATGGTGGTAATAGCAACAATGAGTCCGAGATCTTCAGACCTGGAGGAGGAGATATG
AGGGACAATTGGAGAAGTGAATTATATAAATATAAAGTAGTAAAAATTGAACCATTAGGAGTAGCACCCA
CCAAGGCAAAGAGAAGAGTGGTGCAGAGAGAAAAAAGAGCAGTGGGAATAGGAGCTTTGTTCCTTGGGTT
CTTGGGAGCAGCAGGAAGCACTATGGGCGCAGCCTCAATGACGCTGACGGTACAGGCCAGACAATTATTG
TCTGGTATAGTGCAGCAGCAGAACAATTTGCTGAGGGCTATTGAGGCGCAACAGCATCTGTTGCAACTCA
CAGTCTGGGGCATCAAGCAGCTCCAGGCAAGAATCCTGGCTGTGGAAAGATACCTAAAGGATCAACAGCT
CCTGGGGATTTGGGGTTGCTCTGGAAAACTCATTTGCACCACTGCTGTGCCTTGGAATGCTAGTTGGAGT
AATAAATCTCTGGAACAGATTTGGAATCACACGACCTGGATGGAGTGGGACAGAGAAATTAACAATTACA
CAAGCTTAATACACTCCTTAATTGAAGAATCGCAAAACCAGCAAGAAAAGAATGAACAAGAATTATTGGA
ATTAGATAAATGGGCAAGTTTGTGGAATTGGTTTAACATAACAAATTGGCTGTGGTATATAAAATTATTC
ATAATGATAGTAGGAGGCTTGGTAGGTTTAAGAATAGTTTTTGCTGTACTTTCTATAGTGAATAGAGTTA
GGCAGGGATATTCACCATTATCGTTTCAGACCCACCTCCCAACCCCGAGGGGACCCGACAGGCCCGAAGG
AATA
>NP_057853.1 Tat [Human immunodeficiency virus 1]
MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLS
KQPTSQPRGDPTGPKE
Protective antigen
HIV-1 DNA plasmids expressing Env, Gag and Tat, either alone or combined with the corresponding protein immunogens formulated in the MF59 adjuvant, resulted in protection against an experimental HIV-1 infection in C57Bl/6 mice [Ref1301:Bråve et al., 2007].
tat
Simian-Human immunodeficiency virus strain SHIV-89.6
2828042
CDD:278940
57667
?
tat
10.4
11598.34
158
Transactivating regulatory protein (Tat); pfam00539
>AAB99963.1 tat [Simian-Human immunodeficiency virus]
MEPVDPRLEPWKHPGSKPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLS
KQPSSQPRGDPTGPKEQKKKVERETETDPVH
Protective antigen
tat
Human immunodeficiency virus 2
1845211
CDD:278940
11709
?
tat protein
9.61
14481.48
190
similar to HIV2BEN, GenBank Accession Number M30502, and to HIV2D194, GenBank Accession Number J04542
>AAB47786.1 tat protein [Human immunodeficiency virus 2]
METPLKAPESSLKSYNEPSPCTSEWEVAAQELAKQGEELLAQLHRPLEACTNPCYCKKCSFHCQLCFLKK
GLGIWYVRKGGRRRTPKRTKTHPPSTPDKSISIQTGDSRPTKKQKETPETPVATTSGLGR
Protective antigen
vif
Simian-Human immunodeficiency virus strain SHIV-89.6
2828039
CDD:278957
57667
?
vif
10.5
24244.15
273
Retroviral Vif (Viral infectivity) protein; pfam00559
>AAB99960.1 vif [Simian-Human immunodeficiency virus]
MEEEKRWIAVPTWRIPERLERWHSLIKYLKYKTKDLQKVCYVPHFKVGWAWWTCSRVIFPLQEGSHLEVQ
GYWHLTPEKGWLSTYAVRITWYSKNFWTDVTPNYADILLHSTYFPCFTAGEVRRAIRGEQLLSCCRFPRA
HKYQVPSLQYLALKVVSDVRSQGENPTWKQWRRDNRRGLRMAKQNSRGDKQRGGKPPTKGANFPGLAKVL
GILA
Protective antigen
vpr
Simian-Human immunodeficiency virus strain SHIV-89.6
2828041
CDD:278923
57667
?
vpr
5.91
11514.23
158
VPR/VPX protein; pfam00522
>AAB99962.1 vpr [Simian-Human immunodeficiency virus]
MEERPPENEGPQREPWDEWVVEVLEELKEEALKHFDPRLLTALGNHIYNRHGDTLEGAGELIRILQRALF
MHFRGGCIHSRIGQPGGGNPLSAIPPSRSML
Protective antigen
vpu
Human immunodeficiency virus 1
155945
9629366
HIV1gp7
AF033819
NP_057855
11676
5607
5855
+
Vpu
4.43
8250.01
82
Vpu and gp160 are translated from different reading frames of the same bicistronic mRNA
>gi|9629357:5607-5855 Human immunodeficiency virus 1, complete genome
AATGCAACCTATACCAATAGTAGCAATAGTAGCATTAGTAGTAGCAATAATAATAGCAATAGTTGTGTGG
TCCATAGTAATCATAGAATATAGGAAAATATTAAGACAAAGAAAAATAGACAGGTTAATTGATAGACTAA
TAGAAAGAGCAGAAGACAGTGGCAATGAGAGTGAAGGAGAAATATCAGCACTTGTGGAGATGGGGGTGGA
GATGGGGCACCATGCTCCTTGGGATGTTGATGATCTGTA
>gi|9629366|ref|NP_057855.1| Vpu [Human immunodeficiency virus 1]
MQPIPIVAIVALVVAIIIAIVVWSIVIIEYRKILRQRKIDRLIDRLIERAEDSGNESEGEISALVEMGVE
MGHHAPWDVDDL
Other
vpu
Simian-Human immunodeficiency virus strain SHIV-89.6
2828044
CDD:109608
57667
?
vpu
4.6
8647.38
138
Vpu protein; pfam00558
>AAB99965.1 vpu [Simian-Human immunodeficiency virus]
MQPIQIAIVALVVAIIIAIVVWSIVIIEYRKILRQRKIDRLIDRLIERAEDSGNESEGEISALVEMGVEM
GHHAPWDVDDL
Protective antigen
Aggarwal et al., 2005
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