Arthritis Arthritis is inflammation of one or more of your joints. The main symptoms of arthritis are joint pain and stiffness, which typically worsen with age. The two most common types of arthritis are osteoarthritis and rheumatoid arthritis. Osteoarthritis is usually caused by normal wear and tear, while rheumatoid arthritis is an autoimmune disorder. Other types of arthritis can be caused by uric acid crystals, infections or even an underlying disease, such as psoriasis or lupus (Mayo Clinic - Arthritis). Baboon Papio cynocephalus 9556 Bank vole Clethrionomys glareolus 447135 Bear Ursus americanus 9643 Birds Passeroidea 175121 Brown Trout Salmo trutta 8032 Buffalo Bison bison 9901 Carnivores Vulpes 9625 Cat Felis catus 9685 Catfishes Siluriformes 7995 Cattle Bos taurus 9913 Chicken Gallus gallus 9031 Chimpanzee Pan troglodytes 9598 chinchillas Chinchillidae 10150 Copper Pheasant Syrmaticus soemmerringii 9067 Deer Cervus elaphus 9860 Deer mouse Peromyscus maniculatus 10042 Dog Canis familiaris 9615 Ducks Anas 8835 Ferret Mustela putorius furo 9669 Fish Hyperotreti 117565 Gerbil Gerbillina 10045 Goat Capra hircus 9925 Gray wolf Canis lupus 9612 Guinea pig Cavia porcellus 10141 Hamster Mesocricetus auratus 10036 Horse Equus caballus 9796 Human Homo sapiens 9606 Macaque Macaca fascicularis 9541 Mongolian Gerbil Meriones unguiculatus 10047 Monkey Platyrrhini 9479 Mouse Mus musculus 10090 None None Parrot Psittacidae 9224 Pig Sus scrofa 9823 Rabbit Oryctolagus cuniculus 9986 Rainbow trout Oncorhynchus mykiss 8022 Rat Rattus 10114 Raven Corvus corax 56781 sei whale Balaenoptera borealis 9768 Sheep Ovis aries 9940 Squirrel Spermophilus richardsonii 37591 Tree shrew Tupaiidae 9393 Trouts, salmons & chars Salmoninae 504568 Turkey Meleagris gallopavo 9103 Vole Microtus ochrogaster 79684 Water buffalo Bubalus bubalis 391902 Adjuvant arthritis DNA vaccine CII encoding type II collagen VO_0004409 DNA vaccine Research Intramuscular injection (i.m.) Intramuscular injection (i.m.) DNA vaccine construction In vitro analysis of anti-CII T cells demonstrated reduced production of the pro-inflammatory cytokines IFN-γ and TNF-α in CII vaccinated mice. Further, CII DNA vaccines reduced epitope spreading of auto-reactive B cell responses in CIA (Ho et al., 2006). VO_0000286 DNA encoding CII reduced the disease severity and disease incidence of collagen-induced arthritis to 50% as compared to the PBS-treated control group in which the disease was more severe and the disease incidence was 89% (Ho et al., 2006). CII-stimulated lymphocytes isolated from CIA mice treated with a DNA vaccine encoding CII produced significantly less IFN-g and TNF-a compared to PBS and DNA vector-IL-4 treated mice (Ho et al., 2006). CII-stimulated lymphocytes isolated from CIA mice treated with a DNA vaccine encoding CII produced significantly less IFN-g and TNF-a compared to PBS and DNA vector-IL-4 treated mice (Ho et al., 2006). Adjuvant arthritis DNA vaccine pcDNA-CCOL2A1 encoding type II collagen VO_0004410 DNA vaccine Research pcDNA3 [Ref2328:Song et al., 2009] Intramuscular injection (i.m.) Intramuscular injection (i.m.) DNA vaccine construction Vector pcDNA3 expressed chicken type II collagen (CCOL2A1) (Song et al., 2009). CD4+CD25+Treg cells play a role in restraining auto-aggressive T cells in experimental settings, and 200 μg/kg of pcDNA-CCOL2A1vaccine increased the proportion of CD4+CD25+Treg cells in the blood of arthritic rats compared with those in all other groups (Song et al., 2009). VO_0000286 Comparison of all treated and control groups demonstrated clearly that 200 μg/kg of pcDNA-CCOL2A1 vaccine alone in a single intravenous treatment significantly reduced the severity of disease, footpad swelling, arthritic incidence, clinical scores, and deferred the onset of disease (Song et al., 2009). pcDNA-CCOL2A1 vaccine significantly reduced the levels of serum anti-CII IgG antibodies compared to the negative control group (P < 0.05) (Song et al., 2009). Concentrations of the Th2-cytokine IL-10 in 200 μg/kg of pcDNA-CCOL2A1 vaccine group were significantly higher than those in all other groups, including the MTX positive control group (P < 0.05) (Song et al., 2009). Concentrations of the Th3-cytokine TGF-β in 200 μg/kg of pcDNA-CCOL2A1 vaccine group were significantly higher than those in all other groups, including the MTX positive control group (P < 0.05) (Song et al., 2009). Concentrations of the Th1-cytokine TNF-α in both 200 μg/kg of pcDNA-CCOL2A1 vaccine and MTX groups were significantly lower than those in the negative control and other treatment groups (P < 0.05). Of note, the level of TNF-α in 200 μg/kg of pcDNA-CCOL2A1 vaccine group recovered to that of the normal group (Song et al., 2009). Adjuvant arthritis DNA vaccine pCMV3.65 encoding HSP65 VO_0004407 DNA vaccine Research pcDNA3 [Ref2325:Ragno et al., 1997] Intramuscular injection (i.m.) Intramuscular injection (i.m.) DNA vaccine construction Vector pcDNA3 expressed mycobacterial heat shock protein 65 (hsp65) (Ragno et al., 1997). Rats treated with pCMV3.65 showed a significantly elevated antibody levels (median 0.707) when compared with vector-treated rats (median 0.351; P < 0.01) and with naive animals (median 0.0715; P < 0.01). Similarly, spleen cells from pCMV3.65-treated rats exhibited significantly higher proliferative responses against the mycobacterial recombinant antigen when compared with vector treated animals (P < 0.05) or with naive rats (P < 0.01) (Ragno et al., 1997). VO_0000286 The pCMV3.65-treated rats were significantly protected from disease development in comparison with the control groups injected with the empty plasmid (Ragno et al., 1997). Pristane-induced arthritis DNA vaccine DNA-hsp65 encoding Mycobacterium leprae 65-kDa heat shock protein VO_0004408 DNA vaccine Research pcDNA3 [Ref2326:Santos-Junior et al., 2005] Intramuscular injection (i.m.) Intramuscular injection (i.m.) DNA vaccine construction Vector pcDNA3 expressed hsp65 from M. leprae (Santos-Junior et al., 2005). Cellular and humoral immune responses to the protein are elicited, and long-lived memory lymphocytes are induced (Santos-Junior et al., 2005). VO_0000286 DNA-hsp65 vaccination was protective against arthritis in AIRmax mice (maximal acute inflammatory reaction), as evidenced by the absence of arthritis incidence during the 150-day follow-up period. This protective effect was more pronounced after the onset of pristane-induced arthritis (Santos-Junior et al., 2005). Collagen type II Gallus gallus 395069 45383309 AADN05000742 NP_989757 9031 33 7292547 7311105 + transcript variant X1 8.52 131719.18 1420 >NC_008465.4:7292547-7311105 Gallus gallus breed Red Jungle Fowl isolate RJF #256 chromosome 33, GRCg6a ACGCGGCGTCGGGGCGGTGCGGCACTGCTCGGCCCGACGGACGGTGAGAGGGGCTCCGCCGCCCGCCATG CACGGCCGCCGCCCGCCCCGCTCCGCCGCTCTCCTCCTCCTCCTCCTCCTTCTCACGGCCGCCGCAGCCG CGCAGGACCGCGACCTCCGTGAGTACCACCCGCCGCCCCCCCCCAGGCCCCCCCCGCTCCACCCCGTCGG GACTCGGAGCTGCGGGATCCCTGCGGTGCGGTGGGGGTGCGGGGTGGGGGGTTGGAAGGGGGGAAAGTGG GGTGGAGGTGGAAGTTGTGTGTGTGGGGGGGGGGACAGCGTGGCGTGGAGGGGGGTGGGGGGGAAAGTGC GAAGGAGAACGCGAGATGGGGGGGGCGGTGTGGGGTATGTGGGGAAAGTGATGGAGAGAGTGTGAGGATG GGGGGGACGGTGGGGGGAAATGGGGTGAAGTGTGAGGATGGTGAGGGGGGCGGTGTGGGACAGTGAGGAC GCGTGGGGTGGGGGGGACAGTGAGGGATACGTGGGGAAAGTTTGGGATGAGTGGGGAAAGTGATGGGGAC AGCGTGGGGGTGGGGGGGACGGATGGGACGGTGCAAAGATAGTGGGGTGACAGCGTGGGGTATGTGAGGA CTGCGTGAGGATGGTGGGGGGGGGACAGTGGGGGACAGGTGGGGAAGTGTGAGGATAGTGGAGGGAAGTG GGGGGAACTGTGGGGTACATGGGGACAGTGTGGGATAAATGGGGACAGCGTGAGGGTGGTGGGGGGGGGG ACACAGCAGGGAACAGTGTGGGACAGATGGGGAATGTGTGAGGACAAAGGGGGGACGGTGTGGGAACGGG GGGGACACAGATTGAGACAAAGTGGGCTGATAGGGGGAAAGTGTGACAGTGGGGGTGGGGACAGCGTGGG ACACTGCAGGCTGTGTTAGGACGGGAAGATTGTCTGGGATGGGGGGGGACAGCCTGGGAATGGGGTTTGG GCAGCACTGGGACCATAGCGTACAGCTGAGACAGTGGGGTGCAGAGTGGGGACGGAGAGCTGCAGTGTGG AGCAGTGGGGGACAGCCTGGGGACACAGGTCCAGCTGGGGATGGGATGTGGGGTCCCACTGGGACGTGGG GTCCCATTGGGGACATGGGGTCCCATTGGGGACATGGGGTCCAGCCCTGGGGCCCCTCCTGGCCACCCCG GGGGGCCTCTGGGGACCCTGGAGCACCTCGTGGAGATGCCAGGACACATCCCTGAGGCACGGGGACACCT CCTGGGGGGGATTTTGGGGGTGGCTTCTGGCCATGCAGGGGTACCTCGTGGGGACACATCCTGGGGACCC TGGGGTACCCCCTGAACACACGGGGATGCCTCTTGGGACCCTGGGGTGTAGCCTGGGGGGGGTCCCCAAG GCAGAACATGGTGACTTTGGGCCACCTGCGGGGGATCCCAGTGAGGGACACTTCTTGGGGACCCCAAGGC AACGCATGGGGACTTCAGGGCCCCTCCTGGGGTCCCTGGGACATCTTTTGGGGACACTGAGACACTTCTT GGAGTCCCCAAGGAACAACCTGGAGACTTTGGGGCCCCTCTTGGGGTCCCCGGGACATCTTCTTGGGACC TCGGGGGACCACCTGGGGATGCTGAGGCTCAGTTTGGGGACAGTGGGACACCTTTTGGAGACCTCGGGGA CACCGCGTGGGGACCTGAGGCACAAGTGGGGACCCTGGGGCACCACCCGAGGACCCCCAGGCACACCCCG GAGACCTCAGGACCCTTTTTGTGGACCTTTGGACACCTCCTGGGGACGAACCCTGCAGACCCTTCGGGCT CCATGGGAGCACCGGGGATGCCCCCCCCCCCCCCCCCCCCCCAGGTTCAGTCCCACCAGAAAGCGCTGAT TGTCCGCGAGGGTCCCCGTGTGGCACAGTGACACCGAATGCCATCGGGGTTGGGGCACTCCGGGAGAGGT CTCCTCACTTCCCCCCCCCCCCGCCCCCCCGCTGCGCACCGCCTCGCTGCTTGGGGATCCTTCCTCCTCC TCCTCCTCCTCCTCCTCCTCTGGATGGGATGGAGGCATCGCATCCACACCTCCCCCCCCCGCCCCCGCTG CCGAATCCCCGCGTTTCGCTCCATCCCATGAATCGCTCCATTCATTGCGCACAGCGAAGGCAAACCGGGA GGGGAAGGAGGGTGGGATCGGGGAGGGGGGGGGGTGGGGGGTTCCCCATGCCACCACGGTGCGGGGGTGA TGCCGTCCCCCCCTCCCCACTCCTCCCCCCGTTCCCCACCCCATCGCCCCCGCAGCGGAGGCCGCCGGGG GCTGCGTGCAGGACGGGCAGAGCTACAGCGATAAGGACGTGTGGAAGCCGGAGCCGTGCCGGATCTGCGT GTGCGACACCGGGACCGTTCTGTGCGACGAGATCATCTGCGAGGAGCCGCAGGACTGCCCCAGCCCCGAA ATCCCCTTCGGAGAGTGCTGCCCCGTCTGCCCCGCAGAGCTGCCCGCCGCCGCCCGTAATTTATTTATGA CGCCCCCCCCCCCCCGTCCCCCCAAATCACTTTAATGACCCCCCCCCCCCTCCCCCCCTCCTCCCTCCAC AGATAAATAAATTACCGTGCGCTTAATTGCCCCATGGATGGGGGGCGATCCATGGGGACGGCGGGGAAAA GGCAACTTGGGACCCCCTCCCTAATAGGACCACCACCTCCCCCCCATAGGGACCCCCCCGGGGATCTCTC TCCCCCAAACAGCCGCTTTTCAACATTTTTGGCCCCTTCTTGCCTTTTTTGGGGGCCCTTTGGGGCCTTT TATTGCCCCTTTTGGTCTCTATTTGCTCCATTTTGCCTTTTTGGAGTCCCTTTTATTGCCCCTTTTTTCC TCCATTTCCCCCTTTTTTGCCCTTATTTGCCCCCTTTTTGCCCTTTTTGACCCCTCTTCATCATTTATTA CCCTTTTTTTTGCCACTCTTTACCCCATTCTTGGCACTCTTTGCCCCTTTGGGGTCTTTAATTCCCCCTT TTCCCCCTTTTCCCTTTTTTGCCCAATTTTTGCCCCCATTTGGCCCTGTTTTGCCATTTTGGGCTCCTCG TGGGACATTTATTGCCCCCTTTTCCCTTTCTTGCCCATTATTTGCCATTTTGGGCCCTTTATTCTCATTT ATTCCTTCTTTTATCCTCTTTTTTTCCCTTTAATGCCCCCTTTTCTCCTCTGTTTTCCCCCTTTTTTTGC CCTTATTGTCACTTTTTGGCCCTTTTGGGGCCCTCTTGGAGCTTTTCTTTCCCCTTATTTATCTTTTATG CTCCATTTTGCCATTTTTTTGCACGTTTTTTGCCATTTTGGAGCCCCTCTGTTCCCCCTTTCCCCACTTA TTGCCCCTTTTTTCTCTGTTTACCCAATTTTCTCCTATTTTGGCCATTTTCAGCCTTTTTTTGCCCCCCT CCCCCCCTTTGTTCTCCTTTCCTCCCTTTTCCTCCTCTTCTCCCACTTTCTGGCCTTCCCCCCCTCCCCT TTTTTGCTTTATTTTCCCTTTTATTGATGATTTTTTGCCCCGTTTTCACCTTCTTGGCCATTTTCTTCCC TTTTGCTTCTCTTTTTACTGCCTTTTAACCCATTTCTCCCCCCTTCCCCCCTTTTTTTTTGCCTTAATTT ACCTCTTTTTGGTCCCTTTTTGCCCCTTTTTTTTGGCCTTTTTTATCTCCTTTGTTTCCCCCCATTAATG TTTGCCTTTTTTTCCCCATTTTCCCATTTTTGCTCCCCCCTTTTGCCCTTTTTTTGCCCTCTTTTCCCCT CAGTTGTGACCATTTTCTCCCCATTTTTTTCATTCTCAGTGCCCCCCCCCCCATTTTGCACAACCAAACA CACCCCATGAGGTTGGGGGGGTCACAGCCCCGGGTTGGATTTGGATTTGTTTTTCCTCCCCACAGTGATT TGGCTGCCCCAAATCTCCCATTATTCACCCCAACCCCATTTCCACCCCCAGTGATGGGGAAGAGGCGCTG ACCCCATTTTTCCCACATCAGCCCAACCCCCCCCCCCCCTCACCCCAATCCCCCCCCCCCAAACCCCAAA GTTGCCTTTTTTTAACCCTTTCCTGCCCCCAGCCATGGAGGGGTGAAGGGTTGAGCATTTCCCCCAGCCC AAAGCGCGTGTCCCCGCTTCCGCGTGCTTCGCTTCTGGGGGGGCCCTGAACCCCCCCCAGTGCCCCCAGT GCACCCCAGTTTGACCAACCCCCCCCCCTCCTCGCTCTAATTTATCATTCTTTCTTTCCCTTCCCAACAG GACAACCTGGCCCCAAGGTGAGGCTGTTCCCCCCTCCCACCTCATTTCCAGCATAATCCCAAATTCTGGG GATTTTCAACCTTTTTCTTTGGGGGGGGGGGGGAGGGAGGGGGGGGACTGAATCCTTGGACATGTGTATG GGGATTCGGGTTTGTCTCCTCCTGGGAGGGGTGTTTCACCTCCTGGGGGGGGTTGGTCGCTTCTTGGGGG GGGGGGGGAATCAGAAAGTTGGGGGTGGGCACAAGAGGGGCACCCCCGCTCTCTCTCACCCCCATCTTTG CTTTGCAGGGACAGAAGGGAGAACCCGGAGATATTAAAGATGTAAGTGATGGAGAGCAGGGGGGGTCCCC AACATGGGATGGGGGGGTTGTTACCGTGGGGGTCTCCATGTGCCTTCCTCTCACCCTCCCATTTTCCCCC CCCCCCCCCTTCCCCATGCAGGTTGTAGGACCCCGAGGGCCTCCAGGACCACAGGTGGGAGCGCGTTTCT CCAGGCGCATTGCTGGAATATTTGTGGGGGGGGGGGGGGGGGGGTGGGAATTTTTTAGGGTGGGGGGGTG GTGCTGGGGAGAGCTGACCCCCCCCTCACCTCCTTAGGGCCCAGCAGGAGAGCAGGGACAGCGAGGGGAC CGTGGCGAGAAGGGGGAGAAGGTGAGCGCACCCCCAGAACCGGGGGGGGGGAGCACAAAGCCCATCCCCC CCCCCCACCAACATGGAGCGTTCTGGGGTACAACAGTGCTGTGTCCCCCCCATAGGGTGCTCCTGGCCCC CGTGGAAGGGATGGAGAACCCGGCACCCCTGGAAACCCAGGCCCCCCCGGTCCCCCCGGACCTCCTGGCC CCCCCGGACTTGGTGGAGTGAGTATTGAGGGATGGAGGGGAGGGGGGGGGGGTGGGGCATTTTGGGGTGA AACATGGCAGTTTTGGGGCTGAGCACTTCTCTGTTTGCAGAACTTTGCGGCGCAGATGGCGGGCGGCTTC GATGAGAAGGCGGGTGGAGCGCAGATGGGTGTCATGCAGGGACCCATGGTAAAGCCTCCCCCTCCCCAAA CCCCCCTCCCACCCCAAAACCAGGAGGCCCTCCAGAATTCACACCCCTCTCCCCCCCAGAAACTCAACCC AAACCCACACCAAGGGGTCTCATCCCCTCAGCCCCATTGTGGGACATGGGGGACCCCACAGCACAGCCGC CATTCTGGGGAGGGGTACCCTCTGTCTCTGCAGTCTGGGGTGGGGGTGTGATGGTGGTGAGAGCAACACC CCCCCCCCCCCCATCTCCCCCATAAAACACCCCAAACTCACACCTGGGAGTCCCATAGGGGACCCTGTGC CATCACCACTGTTCTCAGGGGGCACCCTCTGATTTTTTGGGGGGGAGGCGATGGTGTTGATGGCCGCCTC GCTTCCCCCTCCCCCCCAAAAAAAAACCCCACAACCCAACAACACACACCTGGGGGTCTCATCCCTACTG TGGGACATAGGGGGTGTCTCATCCCCCCAGCCCCACTGTGGGACAAAGAGGACCTGCAGCATCACCACCA CTTGGGGGGGGGCACCCTCTGTTTTGGGTGGTGGGGGGGGGTGATGGTGATGACAGCCACCTCAACCCCT CCCCCATGGTGACACTGTCCCTCATCTCTCTCCCTACAGGGCCCTATGGGACCCCGCGGCCCCCCTGGCC CCACTGGCGCACCTGTAAGTACCCGCAGCCCCCCTGGGCTCCGGGGGGCTCCGGTTGGGTGTCCCACCGC CCCCCCAATGCCACCCCCTGTGCTCTCTCCCCACTTTAGGGTCCCCAGGGATTTCAAGGCAACCCCGGTG AGCCCGGCGAACCCGGCGCTGCTGTGAGTGTCCCCTCCTTGTCCCCACTCTGCCCCCCTTTGCGTCCCCC CTCAACTTGGGGACGTGTCTCCTGCCCTCCTCCCCCTCCCCCCCCCACCTCACCGCTGTCTCTTTGTCCC CTGTAGGGTCCGATGGGTCCCCGGGGACCTCCGGGACCACCTGGGAAACCCGGTGACGATGTGAGTCCCC CCGTAACAGCGGTGCTGAGCACGAGCAGCTCGGTGCACTGATACCCCCCTTTCGAGCGCTGCTTCCTCTC CATTAAAACCCCATTATTTCCCTGCAGGGTGAGACAGGCAAACCCGGCAAATCTGGTGAACGTGGCCCCC CCGGCCCCCAGGTGAGGCAGCACTGGGCTGAACGTTGCCCCCATCGCTGCCCCCAACCCTTTTTCCCCTC CCCACCTCAAGTTCACCCTAACCCTATTTCTCTCCACAGGGCGCTCGTGGCTTCCCTGGGACTCCTGGTC TCCCCGGAGTGAAAGGCCACCGAGTGAGTGCCCCCCACCCACACCGTCCCCCCATCACTTATATCCCACC GTGCCCCCTCATAACGTTGTTTCTGCCTCTCTCCCTTCACCCCCAACCAGGGCTACCCCGGTTTGGATGG TGCCAAAGGAGAGGCGGGGGCTCCTGGAGCCAAGGTGAGTGGGGGGCGACCGCCTCCATGGCGTGGGGAT GTGTACCCCAACCTGGGGCTCATCCTCTCTCGACCCTTTTTCCCATACAGGGTGAATCTGGTTCGCCGGG TGAGAACGGCTCCCCCGGCCCCATGGTGAGTGCGGGGGGTGGGCATAGGGGAAACTGAGGCACAGAATAT GAGGACGGACCCCATAACCTCTGCGCTGAGCCCAACCCAACACTGTGCCCCCTCCACCCCCGCAGGGACC CCGTGGGCTGCCCGGAGAGCGAGGACGTCCCGGCCCCTCCGGCGCCGCCGTGAGTGTGACAGTGGCCCTA TGGCACAGGGCTGCGTGTGGGGGGGGATCGGGGTGCTGTGACCCCCCCCATGACTGCCGTCTCCCCCCAG GGTGCTCGTGGCAATGACGGTCTCCCTGGCCCTGCTGGACCCCCTGTAAGTATAGGGCTGCTTTGACCCC ACACCTCAACTTTCTGCTGAACCCCGTAGGGGTTCTCCGGGAGCCCCCCCAGCCTGGGCAGCCCCCCCAC ACTCTCCTGTTCCCCCAGGGACCCGTCGGCCCTGCCGGAGCCCCCGGCTTCCCCGGAGCCCCCGGTTCAA AGGTAAGGGGTGAGCAGAGGGACGTGGGGAGGACTGGGGGGGGGGAAACTGAGGCGCAGTGCCCCGTCTC ACCCCACTTCTCTCCCCCCAGGGTGAAGCCGGCCCCACTGGCGCACGGGGTCCCGAGGGTGCCCAAGGAC CCCGCGGCGAATCCGGCACCCCCGGCTCTCCCGGCCCCGCTGGCGCACCCGTAAGTGTCCCCACTGTCAC ATCCCTGGGATGTCCCATCCTCGTGGCATCCCCTTGGGCTCGGGAGCTGTGGGGATGGGGACACGGCGGG GAGAGTGGGATGGGGGGGGGGATCTGAGCGGCAGAGGGGTTATCCTGTGCTTGGGGATGGGGAAACTGAG GCACGGGGTGAGAGATGTCTCGCTGTTGTTCTTTTAGGGTAACCCAGGGACTGATGGCATCCCCGGTGCC AAGGGCTCGGCGGTGAGTATGGACCAGGGTGGGAAGGGGGGAGGGGTCCCGGAACCTTTGGGGTGGAGCT GGTGGGTCACGTGGGGGATGCTGGGAGTCATAAGGATGCTGGGGGGAGGGTTGGAGGGTGCTGAGGGGTA CGGTGGAGATGTTGGGGGCGCTGGAGGTGCTGTTGGGGGGGGGGATGCTGGGGGGTGTGTAATGTGTGTG GGATGCGGGGGTCACTGTGAGATGCTGGGGGGCAAGGGAGGATGATGAGGGATGTGGGGATGCTGGGGGG TGTGTGGGAGTGCTGGGAGCCATGGAGTCATGGGGGGGGCCATGGGGCCGTGCCGTGCTCCCCCTGACGG CTGCTGTGTGCCTGCAGGGTGCCCCGGGCATTGCAGGCGCTCCAGGATTCCCCGGCCCACGCGGCCCCCC CGGACCCCAAGGTGCCACCGGACCACTGGGACCCAAAGGACAGACGGTAAGAGACCCCCTGAGACCCCCA CGTGGGGACCCCGGGTATGGCCCCGCCCACTGCCAGGTGGCCCCGCCCATACTGGAGGTAGCCCCGCCCA CTTTGCCCCAGGCCCCGCCCACCGTGCCGCAGGATGCGCCCCCTGCAGGACCCCAATGTGGGGCACTCTG TGTCCCCTCCCCAAAGTGCCCCATGGTCACTCCCAGGAGACCCTCTTCTGGTCCCCAAAGGGGCCACTGG GGATGGGATGGGTGATGAGGTTGGGGTGGGATGGGAATGGGATGAGATGAGATGGGAATGTGACGGTGAT GGGGATGAGATGGGCACGTGGGTGGGTATAGGGACAGGAAAGAGGATGAGGAAAGGGCTGGGGACATGGA TGGTGGTGGGGAGGAGGATAGGGTTGAGGATATGGGAAATGGGGGATGGGAAAGGGGATGGGGCTGAAGA ATAAGAGGGAGATTAAGAAGGGGGCAGCTGTGGTTAGGGATTGAGGTGGGGATGGGGACACAGCTGGGAA TAGATGGAGGCAGGAATGGGAGGGGTGTGCAGGGGAAAAGGGATGGAGGATACAGGTGGGGATGGAGTGG GAATAGAGATGGGAGTGAGACTGTAGGGCAGGGAAAGGGATGGGGGACAGTGACGGTGTGGGGACAGAGA TGGAATGGGGACAGGGATTTGATGGGGACAAGGATGCAGATAGGGGTGAAGGTAGGGGTAGGGGCAGGAA AAATGCTGGAGAGATGGGGACGGGACGGAATTGGGATAGAAATGGGGTGGGGTGGGATGGGAATGAGGCC GGGAATGGGAATGGGAATAGGGCTGGGGTTGGGATGGGGACCGCGATGGGGGCACTGAGAGCCCATTGCC CACCGCCCTCTCTTCCCCCAGGGCGAACCCGGCATCGCAGGCTTCAAGGGCGAGCAAGGACCGAAGGGCG AGACGGTGAGTTCTGGGGGGGCCCATCCAGCCCCCCCCCCATCCGGGGAGGACCCCGCTGCGGGGCTGCG TCTCTAACGAACCTCTTCCCCTAACGAGGCCCCTCGAGGGGCAGCATCCCCCCTCCTGCAGCGGGGGGTG GAGGGGGAACAATAGGCTCTGTGTTAGGGCCGCGCTGTGCCCCCCCCTCGGCCCCGGGGCCGGGGACATT CCCCCATCGCTTCATTAACCAACCTCAATGCGTGGGGCCGCTTCCCACTGCGGGGCCGCTGAGCCCCGGC GCCGTCGTGACATGCAGCACCGTGTGGACCCCCGGAGATGGGGCTTTTGGTTGGGGGGGGGGGGCTGCGA ACTGAACCCCAACCCCCCACCCGTCCCGGTTTGCTGCTCTGACCCCTTTTCCTCCTCTTCCTCAGGGCCC CGCAGGACCCCAAGGTGCCCCCGGGCCGGCTGGCGAGGAAGGCAAGAGAGGAGCTCGTGGTGAACCTGGT GCCGCCGGCCCTGTGGGCCCCCCCGGAGAAAGGGTGTGTGCAGAGCGCTGCCCCCCACCCCGAAAAAGAC AAAAACCCCACAGCCAGCCCTGACTTTGCCCCTCTTCTTCTTCTTCCATAGGGCGCTCCTGGCAACCGTG GATTCCCCGGGCAGGACGGGCTGGCCGGACCCAAGGTGGGACTTCGGGGTTATGGGGGGGGGTCCTATAG GGAGTGCCGACTCCCTGTGCCCCCCTCCAACCTGTGCCCCCCTTCCCCCCACACAGGGTGCTCCAGGTGA ACGCGGCCCCGCTGGTCTTGCCGGTCCCAAAGGTGCCACCGGTGACCCCGGACGTCCCGGAGAGCCCGGG CTGCCCGGAGCGAGGGTGAGAGCTGGGGGGGAGTCCCCATGGGGGGGTGGGGGTGCTGGGGGGGCTCAGG TGGGGCAGAGGGATGTGGGGTGGTGGTGGTGGGGGCTGCTGGGGTCAGCAAGGAGGGGTTTGGGGAGCAG TTCAGGGGGTTTTGGGGTTGGTTAAGGAGCATTTTGGGTTTGTTAAGGAGCATTTGGGGTTGGTTAGGGG ACGTTTGAGGTTTGTTACAGAACATTTGGGGTTGGTTAGGGAGCTTTGGGGGGTTGATGCCTTTGGGGTT GCTTCCTTTGGTTTCAGCCACGAAGCGCTTTGCCATGAAGGTGCTCTTTGGGGTTGGTTCAGGTGCTGCT GGGCTCTGATCAGGATGCACTTTGGCATCAGCTGAGATGCACGTAGGGGTGGTTACGGTGCAGGTGGGGC TCATTGTGGTGCATTAGGGGTGGGGGTGCTCCTTGGTGCTCATTAACGTTGTCTGTGGGGTGAGTTAGGA TGCATTTGGGATGAGTTAAGTTGCTTTTGGAGTTACCAAAGGTGCTCCCTGGGGTTACTAAAGATGCTCT TTAAGGGCACGCAGCCCCCCGTGCCCTCACCCGGCCCATTTCAGCCCTGGAGCTGGGCAGGGCAGGGGTT CCCATTGTATCCCCCTCCCAACTGGGGGCCACCCGCTGCAGCCCCCACTGCTTCCTTCCCCTGCAGGGTC TCACCGGCCGCCCTGGCGATGCGGGACCTCAAGGCAAAGTCGGCCCAACTGTAAGTGATGCTCTATGGGG TGGGGGAAGGAGGGCTGGGGGTGGCTGTTGTGACCCACGCCGATGTTCCCCTCCCCATGTAGGGTGCTCC TGGCGAGGATGGCCGCCCCGGCCCCCCCGGCCCTCAGGGTGCTCGTGGGCAGCCCGGTGTGATGGGTTTC CCCGGTCCCAAAGGCGCTAATGTGAGTATTGACCATTTTCTGCCCCAAAATGGAGCTGTGAAGGTCAGCG CAGCTGTGAGCCCATCCCGTCTCCTCTCTGTAGGGTGAGCCTGGAAAAGCTGGAGAGAAAGGACTGCCCG GCGCTCCAGGGCTGCGGGTGAGCTCCTTCTGCCACTCTGACCCCATAAAATCACCTTGTGGGGTTTCCCC TGCACTGTGCCCTGTATGTGGATGGGGAAACTGAGGCACGGGGCTGAGTGCCGGGGATTTCTCCTCTGCA GGGTCTGCCTGGCAAGGATGGGGAGACGGGAGCTGCCGGCCCCCCTGGACCCGCTGTGAGTGTCCCTTCT TTTCCTCTTGGGGACAGATGTTTGAAATGTGGGGCTGGGGGGTGTAGCCCCCAGATCTGGGTGGAAGACC AGCCCAGGAGTGCTGGAGATACGGGGTGGGCAAAAGCCCCGGTGTTGAAGTGTGGGGATTTGGTGTCCCA GCCGCCCCATCCCGGTGTGATTTGGATTTTGCCCAAAACCTTGGGGTGGGTGAGGGGCTGCAAAGGGGCG AATCCAGGAGGGAGGAGGGATCTCAGAGCTGTCACTGCTGTCCTCCCTTTAGGGTCCTGTGGGTGAGAGA GGAGAGCAAGGAGCCCCCGGTCCTTCCGGCTTCCAGGTGAGTGGGGACACACAAGGAGGGTTGGGGTGAT GCAGGTGGGCACCCCCCCCTAACACCACTCCTTGTCCCCAAACAGGGACTGCCCGGACCACCAGGTCCCC CTGGGGAGAGCGGCAAACCCGGAGACCAGGTGAGGCCATTCATCCCTAGGCTGCAAGTGGGGGCTTAGCC TGTGCTGACCCCCCCCCCCCCCCCCCCCCAGTGCTGACCCCCCCAGTGCTGACCCCTGGCTCTTCCCTCC TCTCTGCAGGGTGTTCCTGGAGAAGCCGGTGCCCCCGGTCTTGTTGGTCCCAGAGTGAGTATTGCTCATC CCCCCCCCGCTCCTCCTGTCCCACTGAAGGGTTTGGGGGCTCAGGGGGGAGCAGAATCCAACCACCCCCA CCAAAGCCATCGGACCCCCACAGTTCCAGCAGCTCAGTGTCCCCCCTCTCCTCCCAGTTCACCCCAATCC CACCTGGGATGGATGCGCTGCCCTCTGTCCTGAGGACAGTGCCATTGTGTTCCTCACTATGGCCTCGGGG GGCTTCTCTCTGACCGTCTCCCCCTCTCCCCCCCATAGGGTGAACGTGGATTCCCCGGTGAACGCGGCTC TCCCGGTGCCCAAGGGCTGCAGGGTCCCCGTGGGCTCCCCGGAACGCCCGGCACTGACGGACCCAAGGTG GGTGACAGAGGATGGGTGGCACAGTGCCACCACCATGGAGCCGTGATGCCATCGCGGCCCCAATGACCTC ATCACTGTTCTGCTTTTAGGGTGCAACCGGTCCAGCCGGCCCCAACGGTGCCCAGGGTCCCCCAGGGCTG CAGGGAATGCCCGGTGAGAGAGGAGCAGCTGGCATCGCTGGCCCCAAGGGTGACCGGGTAAGGTGATGCG TCCCATAAGTGTCCTGAGTGACATCGGGTCTCAGCTCGGCTCACACTCATCCCATCCCACAGGGAGATGT TGGTGAGAAAGGACCTGAGGGAGCTCCAGGCAAGGATGGCGCACGTGTAAGTGGGGCACGGCCATGGGGT GGGCTGGCAAAGGATGCTCACAGAGACCACATCCTCATCTCTCTCTCTCTCCCATAGGGTCTGACGGGTC CCATTGGTCCCCCTGGCCCTGCTGGCCCCAACGGTGAGAAGGTGAGAGCAGCATCACAGCACCCCACATT ACGCCCCATGGGATGACCCCAGTGCCTCCACCTCTCCATCCTTTCTTTTCCAGGGTGAATCCGGCCCTCC TGGTCCATCTGGTGCTGCCGGTGCCCGTGGTGCCCCCGTAAGCACAATGTCTGCAGCCCCTGGGTGCCCC TAACCTTCACCCTAAACCCCCATCAACCCCTTTATCAACCTCCCCCATCTCTTCCCATTAGGGTGAGCGT GGCGAGCCCGGTGCCCCCGGTCCTGCTGGATTTGCTGGCCCCCCGGTGAGTGTTTCACCCCGAAGCCCCC ATCGCACACCCACGTCTTCACCCCACATCCTCACCCCACTCATGGTGGCTGCTGTTCCCATCAGGGCGCC GATGGACAACCCGGTGCCAAAGGCGAGCAGGGAGAGCCCGGGCAGAAGGGTGACGCGGGCGCTCCTGGTC CCCAAGGTCCCTCCGGCGCTCCTGGCCCCCAGGTACAACCCCAAATGGGGCAAACCCCCAAATTTGGGAC GTCACGGCCCCAATGCAGGCACACTGCAGCTCCCGTTCGGATTTGTAACCTGTTTTTCTCTCCTTCCTAG GGTCCAACCGGTGTCACTGGTCCCAAAGGAGCTCGTGGGGCTCAGGGTCCCCCTGTGAGTACCGGGGGGT GGGCTGCAGGGTGGGGAAGGAACGGCCGTGGGGCTGAGCTGTGTCTGAGCCGTTTCTCCTCTCCCTCTCT CCTCTGACTCTGTGATTCCCTCCCCAGGGAGCCACGGGATTCCCCGGAGCTGCCGGCCGTGTGGGACCGC CCGGCCCTAATGTGAGTCTGGGGGCGTTCTGGGATTGCCCCCACCTGGGGTTTGGGTGCTGCTTCTCCGT GCTGCGTGTTGGAGGGGGCACTGTTTCCCTGCACAGACACGTGGGGTTTTCCTCCTTGGCTCTCTGATGT TGGCTTTTGGGGCCATTCCAGTGGTAGAGAAGGACTTTTCTAAGGGCAAGAGCTCCCCAAGAAGCAGCAG TGGGATGCGGGTGATAAAGATGGAATGGCTGCCTCTGGTTTGCACCAGCGCTGCTTTCCTTCCCTTTAGG GTAACCCAGGCCCCCCCGGACCCCCTGGCTCTGCTGGCAAAGACGGCCCCAAGGGTGTTCGTGGCGACGC CGGCCCCCCCGGCCGTGCAGGTGACCCCGGCCTCCAAGGCCCCGCCGGCCCCCCCGGCGAGAAGGGCGAA CCCGGCGAGGACGGCCCCGCGGTGAGGATTCTGGGGGTCTCCTCCCTCCGTGCACCCCCTGGCTGCGTGG TGCCGTTGTTCTTAGTCTGATTTCCCCCTCTGCCGCCCTGCAGGGTCCCGACGGCCCCCCCGGCCCTCAA GGCTTGGCAGGACAGCGTGGTATTGTGGGTCTCCCAGGACAGCGTGGTGAGAGAGGCTTCCCCGGACTGC CGGGGCCATCGGTGAGTGGGTCGCTCTCATTTGGGTGCACTGAATCCTATGGGGTGCAGAGATGTGGGGG CCGCGATGCTCTGGAGCCCATCTCAGGGGTCGCCAGCCCTTTGGTGCAGCCCGGGGACACCGTTTGCAGG TGGGTTGGGGTTTTGCAGAGCTCCTTTTTCCCCACCAGGAGCCGCTGGTGCAAGGCTTAAAGCCGGGGCA GGAAAACCATCGGTGGTTATTTGTTGCAGAGGGGTCTGGGAGCCATAAAAAACGGGGAAGGGGCAGCGCT GGGGTCTCTCCCACTCATGCACTTCTTTCCCCTCTTTCAGGGAGAACCTGGAAAGCAAGGAGCGCCTGGC TCTGCGGGTGACCGAGGTCCCCCCGGCCCCGTGGGGCCCCCTGGGCTGACAGGTCCTGCTGGAGAACCCG GGCGCGAGGTAAGCAAAACCCCACAGCATCACAGCGGCACCGGGCATCACCAACCCCATGGCACAGCTCA GCTCCCAGAGCTCCCCGGTGTCTTTTTCTCCAGCACTGAAAGGAGACTTTGCACAAATCCTGCTCCACCC GGGTTGTAACATCCCCTTTTCCTCCTAGGGCAACCCTGGTGCTGACGGTCCCCCAGGCAGGGATGGCGCA GCTGGCGTGAAGGTGAGCTTGCCATGCGCTCCCCATTGGCACTCGCCATCCCCGTGCCAAAAGCTGTGGG GTTTTGCACAGATCTGACCTCTCTGTTGTCTGCTCGCAGGGTGATCGTGGTGAGACCGGCCCTGTGGGTG CCCCCGGTGCTCCTGGAGCCCCTGGCGCCCCCGGCCCTGTTGGTCCCACTGGAAAACAAGGAGACAGAGG CGAGACGGTGAGTGCTGGCACAAGGGTTTAGGGTTTAGGGTCTCCTTATGGCTGAAAATGTGCAGGGGTT CCCCTCGAGGTTTGTTCCTTGCACCAGTGCTGAGAGCATTTAAAGATGCTGTGAGGCACCAATAGCTGCT GATTGTCACTGTTGCCCGGATCTGGGGTGCGGAGCATGGGGCTGGCTCAGACACCCCCGAAATCCCAAAT TCATGGCTTCGAGGTGGTGCTTCTGGTCGCTGGCACCTTCTGATGTCCTTTTTTTCTCCCTGCAGGGTGC ACAAGGGCCCATGGGTCCCTCTGGTCCCGCTGGAGCTCGAGGAATGCCGGTGAGTGGTGCTGAGTGCATC GGCACATCCCACGTACAGAGCGTGGGGTCCTCCGTGCCAGGAGGGGGTCTGCCACCCTGAGCCCGACACA GCCCTGTCCCCACTTTAGGGTCCCCAAGGACCTCGTGGTGACAAAGGTGAGACGGGAGAGGCTGGAGAGA GAGGGCTGAAGGGCCACCGTGGCTTCACCGGTCTGCAGGGTCTGCCCGGACCACCCGTAAGTTGGTTTGG GGAGCACTGAGCCCCCCCCCCCCGTACGATGTGGCTCCTTTGGGGTCTCTGTGGCCACCGAGGCTCTGTC TGGCCCAAAGTGCTGACCGCAGAGCTGTGACCACCCCGGCTTCCTCCTCAGGGCCCGTCTGGAGACCAAG GTGCTGCCGGTCCCGCTGGTCCCTCCGGTCCCAGAGTAAGTCCTGACAGTGGTGTTTGGGGTGGTGGAAG GGGAAGGAGCAGCAGTGGCCTCCCTGGGCACCTGCAGCCTCTGTTCGCTCCTGTCTGCTCATCAGCACCA TCGCCTTCCCTGCCCTGAGGCCCCGCAATGCCTTCACCTCCCCGTTTTGGGGCTCTCTCCTAGGGTCCCC CTGGTCCCGTCGGCCCCTCTGGCAAAGATGGCTCTAACGGCATGCCCGGCCCCATCGGTCCTCCCGGTCC CCGTGGACGGAGTGGTGAACCCGGCCCTGCGGTGAGTCCTGGTGAGGGGAGGCAGGGAATGGGGTCCAGC TCGCAGAGCAGCCCATCAGCATCACTTCTTTCTCCCATAGGGTCCTCCTGGAAACCCCGGTCCTCCCGGT CCTCCTGGCCCCCCCGGCACCGGCATCGACATGTCTGCTTTTGCTGGACTGGGTCAGACGGAGAAGGGCC CCGACCCCATCCGCTACATGAGGGCAGACGAGGCGGCCGGAGGGCTGCGGCAGCACGACGTGGAGGTGGA TGCCACCCTCAAATCCCTCAACAATCAGATTGAGAGCATCCGCAGCCCCGAGGGCTCCAAGAAGAACCCT GCCAGGACCTGCCGCGACATCAAACTCTGCCATCCCGAGTGGAAGAGCGGTAAGAGCTCCGCGTGCCTCT CCCGTCCTCCCCTCTTCCCCACAGGAGAGCATCCCCAGCATCCTCGCACCGACCTGCGGTCAGGTTGGAT GTTAGGAAAGATTCCTTGTCCAAAAGAGCTCTGGGCGCTGGGCTGGGCTGCCCGGGGAGGTGGGGCAGTC GCTGTCCCCATAGGTGTTGGGGAACTGTGGAGATGTGGCACTTGGGAGCGTGGCTTAGTGGGGATGAGGC AGCAGTTGGACCAATCTTCGAGGTCTTCTCCAGTCTTAATGGCTCTGTGCTTCTGTCGGTGTGCATGGTG GTGATGGGTGGCCATTTAGACTTGGCGATCTTTGAGGTCTTTTCCGATCTTAACGACTCCTAGACCTCCC CAACCCCATGAACGCTGTTTGTCCTCCCCCCTGCAGGAGATTACTGGATTGACCCGAACCAGGGCTGCAC CTTGGACGCCATCAAAGTATTCTGCAACATGGAGACGGGCGAGACCTGCGTCTACCCGACCCCCAGCAGC ATCCCCAGGAAGAACTGGTGGACCAGCAAGACGAAAGACAAGAAGCACGTCTGGTTTGCAGAGACCATCA ACGGCGGTTTCCACGTGGGTGTCCCCCGGGTGTCCTTGGAAGGATCGATCCCACCTGGGATGTCCTTCTT GCGGTCATGTGGATGGGTTTTAATGAAGTTATAGAGGGTGATTCTGAAGGTGTAGGTTTGGGTCAGTTCA GCTCCACAAATCAAAGGGAAAGGATGGGATGGAGCAACTGAGCTCCCTCGGTTTGTTTGGCCCAGAAAAG GTGAGGATGAGGGGAGGCCTCACGGCCCTACAGCCCCTTACGGCCCTACAGCAGCGTTAGGAAAAAAGTT CTGCCCCGGAGCTGTGTTGGGCACAGAACAGCCCTGTGATGCCGGAGCTCGGGGAGCATTGGGACAACGC TCTCAGACATTGGGTTTGGGTCAGGTCCTGGGTAACGTGATGTGCAGGGGGCAACCAGCCCATGGGTGGG CTTTAAGGACCCTTCCAAGCCAACCATTCCATGGTTCTGTGATCTGTAAGGACCTTTCCAATCCAAACCA CTCTGATTTTTTTCTCAGCCATTTGGGAACCTGAAGTACGGAAGTCCTCCCAAAAAGCTCCTGAGAGTAA GGTGGTCATAATGCCCGCAGGCTTTAACTCCTCACCTCTTCCCTCCAGTTCAGCTACGGCGATGAGAACC TGTCCCCCAACACCGCCAGCATCCAGATGACCTTCCTGCGCCTCCTGTCCACCGAGGGCTCCCAGAACGT CACCTACCACTGCAAGAACAGCATCGCCTACATGGACGAGGAGACGGGCAACCTGAAGAAAGCCATCCTC ATCCAGGGATCCAACGACGTGGAGATCAGAGCCGAGGGCAACAGCAGGTTCACCTACAGCGTCTTGGAGG ACGGCTGCACGGTAGGTTGCTGGGCGCCTGCAAAGGAAAGGTGCAGATGGGGAGGGGGATGCTGAGGCTG CGGGGATGAGGCCGGAGCAGCTGACAGCATCCCTGCCCTCCTTCCCTCCCCAGAAACACACTGGCAAATG GGGCAAGACGGTGATCGAGTACCGGTCGCAGAAGACCTCGCGCCTGCCCATTGTAGATATTGCACCTATG GACATTGGCGGAGCCGATCAGGAGTTTGGCGTGGATATTGGCCCAGTCTGCTTCTTGTAAAAAGGGTTGT TGTTATTTGTGTGTTTGTTTGTTGTTTGGTTGTTGTTTTTTGTTTCTTTTTTTTTTTTTTTTAAAAAAAA GAAAGGAATCCAGCCCAATCCCATAAAAGCAAACCAGTCCCACCCCCAGGACCCGCACGTTCCCAGCACA ACTTCTGCACTGAACGGATGGCACGACCCCGCGCCCCTTCGGGACCCTCCGGCGCCGTCACCGGGCAGAC TGCGAAATACAACCACGGGCTTATATTTATTTATTGCCTTCCTGGAAGGCCTGGTTTCGTAGGGCGGGTG GAGGTGGGAATCAATCTGGCAGGTGTGACGGCCCCCCTCCCCACAAAGGGATCTGGCAAACGCAGGTATC GCGAATCCCCTCCCCTCCCCGTGTATCACCAGCAGGAGTGCTAATGTATCATACAACAGAAATGGTGCTA TTCTTGTAAAACAAGTCTGTATTTTTTAACATCAGTTGATATAAAAACAACAAAAAAAAAAACTTTTGGT GGAAAGTAA >NP_989757.1 collagen alpha-1(II) chain precursor [Gallus gallus] MHGRRPPRSAALLLLLLLLTAAAAAQDRDLRQPGPKGQKGEPGDIKDVVGPRGPPGPQGPAGEQGQRGDR GEKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQMGVMQGPMGPMG PRGPPGPTGAPGPQGFQGNPGEPGEPGAAGPMGPRGPPGPPGKPGDDGETGKPGKSGERGPPGPQGARGF PGTPGLPGVKGHRGYPGLDGAKGEAGAPGAKGESGSPGENGSPGPMGPRGLPGERGRPGPSGAAGARGND GLPGPAGPPGPVGPAGAPGFPGAPGSKGEAGPTGARGPEGAQGPRGESGTPGSPGPAGAPGNPGTDGIPG AKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGETGPAGPQGAPGPAGE EGKRGARGEPGAAGPVGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPAGLAGPKGATGDPGRPGEPGLP GARGLTGRPGDAGPQGKVGPTGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPG LRGLPGKDGETGAAGPPGPAGPVGERGEQGAPGPSGFQGLPGPPGPPGESGKPGDQGVPGEAGAPGLVGP RGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGATGPAGPNGAQGPPGLQGMPGERGAAGIAGLKGDR GDVGEKGPEGAPGKDGARGLTGPIGPPGPAGPNGEKGESGPPGPSGAAGARGAPGERGEPGAPGPAGFAG PPGADGQPGAKGEQGEPGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGP PGPNGNPGPPGPPGSAGKDGPKGVRGDAGPPGRAGDPGLQGPAGPPGEKGEPGEDGPAGPDGPPGPQGLA GQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGSAGDRGPPGPVGPPGLTGPAGEPGREGNPGADGLPG RDGAAGVKGDRGETGPVGAPGAPGAPGAPGPVGPTGKQGDRGETGAQGPMGPSGPAGARGMPGPQGPRGD KGETGEAGERGLKGHRGFTGLQGLPGPPGPSGDQGAAGPAGPSGPRGPPGPVGPSGKDGSNGMPGPIGPP GPRGRSGEPGPAGPPGNPGPPGPPGPPGTGIDMSAFAGLGQTEKGPDPIRYMRADEAAGGLRQHDVEVDA TLKSLNNQIESIRSPEGSKKNPARTCRDIKLCHPEWKSGDYWIDPNQGCTLDAIKVFCNMETGETCVYPT PSSIPRKNWWTSKTKDKKHVWFAETINGGFHFSYGDENLSPNTASIQMTFLRLLSTEGSQNVTYHCKNSI AYMDEETGNLKKAILIQGSNDVEIRAEGNSRFTYSVLEDGCTKHTGKWGKTVIEYRLQKTSRLSIVDTAP MDIGGADQEFGVDIGPVCFL Protective antigen Collagen type II Mus musculus 12824 169658375 AC113444 NP_001106987 10090 15 97975601 98004723 - transcript variant 2 8.58 131740.08 1419 Also known as Dmm; Lpk; Col2; Del1; Col2a; Col2a-1; M100856; Rgsc856 >NC_000081.6:97975601-98004723 Mus musculus strain C57BL/6J chromosome 15, GRCm38.p4 C57BL/6J ATCCTTTCCAATGATTTTTTTTTTTTTGGTTTTTAATATCAATTGATGTTTTAAAAAATACAGAGGTGTT TGACACAGAATAGCACCATTGTGTAGGACACGCAGTCCCTGCGCCCAGCATCTGTAGGGGTCTTCTGGCT GGGCTGGGAACAGTCACTCGGGGGGCGTCTGACTCACACCAGATAGTTCCTGTCTCCGCCTGGACCCAGA GGTCTTACAGGAAGACAATAAATAAATAGAACACCGAGATTTTATTTTGCAGTCTGCCCAGTTCAGGTCT CTTAGAAAGGGGAGCACAGTCCGGGCTGTGAGGGGAGGACGGTTGGGTATCATCAGGTCAGGTCAGCCAT TCAGTGCAGATCCTGGAGTGACTGCGGTTGGAAAGTGTTTGGGTCCTTTGGGTTCGCAATGGATTGTGTT GTTTCAGGGTTCGGGGGTTTTACAAGAAGCAGACAGGCCCTATGTCCACACCAAATTCCTGTTCAGCCCC TCCAATGTCCATGGGTGCGATGTCAATAATGGGAAGGCGGGAGGTCTTCTGTGATCGGTACTCGATGACG GTCTTGCCCCACTTACCAGTGTGTTTCTAGGCAGAAAAGGGGAGGTGTCATTTGGGCGATGCCTTACAGC AAGGACTGGCTACTTAGCACCCCCAAACTAAGCAGCCACAAGGTAGGGACGACACTGGGTGGCTTGCTAG AACTTCTCTCCATTTGCCCAAGCCCTCTCCTCTTCAATTGTCCCCTTGATGGTAGAGCCCTCCTCTACTT GTCTTCCTCCTTCCCACAGAGGGCTTCCTGCCTGGGATAGCCTCTCCTCTCCTATGCTAGTTTCTACGAA TACTTCTATAAGAGTTAGTGAGCTTGCCAGCATCTTTATTGCCTCTGAATGAGGAAGTGGACAAGCCAGT ATGGTATACGCTCCTCCCCCATCCCTGCCTCTCAGCTTGTCTCCCACATGCCCCCACGACTCAAGCCTCT AATGAGTCCCTTCACTACAGGAAAGTGACATTTGTCACAGGCTGACCTCAGCCCCACTCACCGTGCAGCC ATCCTTCAGGGCAGTGTATGTGAACCTGCTGTTGCCCTCGGCCCTCATCTCTACATCATTGGAGCCCTGG ATGAGCAAGGCCTTCTTGAGGTTGCCAGCCGCTTCGTCCAGGTAGGCGATGCTGTTCTTACAGTGGTAGG TGATGTTCTGGGAGCCCTCAGTGGACAGTAGACGGAGGAAAGTCATCTGGACGTTAGCGGTGTTGGGAGC CAGGTTGCCATCGCCATAGCTGAACTGTGGGGCAGAGGGGCGAGGGTTGTGAGACCAGGGGCCTAGCATC TGCTGGGATCAGAGGCTAACAGTACATTCATCTGATAGGGGCTCAGAGCATCAGATGGGCCCTGGGGCAG GTGTGGAGCAAGCTCAGAGGACATCTTCTCTCGCTCTAATGGGGAAAATACTTTCTCCTCTTTCTTTCTT CTAAGGCCCAAAGGGACACCGGCGGAGGATGCCAAGAAGGAGCTAAAGAATCGGAGGAGAGAGAAGAGCA CTCAGGAGGGACCAGCTGAGCCTAGACCACCGGGCACTCACGTGGAAGCCACCGTTCATGGTCTCTCCAA ACCAGATGTGTTTCTTTTCCTTGCTCTTGCTGCTCCACCAGTTTTTCCGAGGGACAGTCGCTGGGTTGGG GTAGACGCAAGTCTCGCCGGTCTCCATGTTGCAGAAAACTTTCATGGCGTCCAAGGTGCAGCCCTGGTTG GGATCAATCCAGTAGTCTCCTGCAGGAAAAAGAGGCAGCATCCCATGATGCTTTGCAAGACAGCCTACTG GGAAACAAGTCAGGGGAGGCTTACATGTGGCCTAAGTGGGGGCCAGACAGAAGGGCATGGGAACAAAGAA ATCTGCATGGAAAACCTAATGCTAAAGAGGGGTCCAAGGAAAAAGGGAGAGGCAGAGCTTCCCTGCTGGA CAGAGTCACTTCTGTCATGGTCCTTCACCAGAACTTTCTAGGTCTAACCCCGCTTTGCACTACGGTACAA TGGGGTGTGTCTTCCTGGCTGCTGAAGGCGGACATATTGGTGGGCTGGCTCTCTCCTCTCTGGGGGAGGG GTCCTGCCCTCCAGGCTCACCGCTCTTCCACTCGGGGTGGCAGAGTTTCAGGTCTTGGCAAGTGCGAGCA GGGTTCTTGCGGGAGCCGTCGGGGCTGCGGATGCTCTCAATCTGGTTGTTCAGTGACTTGAGTGTAGCGT CCACCTCCACGTCGTGCTGTCTCAAGGTACTGTCTGCCTCGTCGGCCCGCATGTACTGCATGGGGTCGGG GCCCTTCTCTCTCTGCCCTAAGCCAGCAAAGGCTGACATGTCGATGCCAGGACCAGGAGGACCTGGAGGG CCAGGAGGACCGGGACTTCCAGGGGGACCCTGAAGCAGTAAATAGAGATGTCAGCTAGGAATCACAGGAC AAGGCCCTCCTCTGTGCCCATCTGCTGGGACTATGCTAGTCCTCTTCTTGCTCATCTGGTGGGGACAGAG GACAACAGGACCAAGAAAACCACAGCAACTTCCCCACTGCCTCCCTGGCTCTTCTGTTTCCCAGAACCCC TCATGAGCCCTGTGACCCTCAGCTGGCCCTCAGTCTGTAGGATGCCTTCCCCATTAGTTGCCAGCTGATG TTCCAAAGGCCCTATAAAATGCTGGGGATACCTCCGATGGTGGAAGGGGGAGGGTGGGGTGGGGTCAGGA CACTTACAACAGGGCCTGTTTCTCCTGAGCGTCCACGGGGACCTGGAGGCCCGATGGGGCCAGGGATTCC ATTAGAGCCATCTTTGCCAGAGGGACCAACAGGGCCAGGTGGACCCTATAAGCCAAGAGAGAGGAAATGG TAGGAAAATAGCCTCTGAGTAGTGTAGTGGAGCAGCTATGGCTAGGTGGGTGGCCAGCCCCATGGTGCTG GTCATACCATTCTGTCTCTGATCCCTGCATTCCTCAGCCACACTCCCTAAATGCAGCTCCATTTAGCCAA AGGACTAGCAGGTTAGTTCCATGTCCCTCCTAAGTCATGTTTATAAAAATCTTATTTTATCAGGCTTGTC TTCCAGCCAGTGTGACCTCAGATGTTTAGGCCACAGCCAGTGCAAGAGAGTCCCGCTTTTCTCGGGCTAC CTCCTGGAAGGACTGCTAAATCCAAGGTGCCCTGAAGAATCAATGCTCATATCCATCATCTCCTGGCTGA GGCCTTGGCCCACCCAGCAGAAAAGCTCATTCCACCCCCTGAAACCATCACACTTACTCTAGGGCCAGAA GGACCAGCAGGGCCAGAAGCACCCTGATCTCCAGAAGGACCCTGTGGAAAAGAAGAAAACAGCGGAGGTC AACACAGCTGGGTATAGAAATACATCTTCTTCAGAATGGGAAACAGTCACGTGCACCCCCCCCCCCTTGT ACCCACTAAGAGATTCCAGTGCCTTCTGAGAAAGATGCTAAGCCTTTTGGGTAGCAGGAGAAGCTCAGGG GGTCTGAAAAGTAGGAGGTCTTGGGCAGCCCCCTCATGGACAAATGACATGCAGTGACACCCACCGGAGG GCCAGGCAGACCCTGCAGTCCAGTGAAACCTCGGTGTCCCTTCAGTCCCCTCTCGCCCTGCTCTCCAGAT TCTCCTTTGTCACCTCGGGGGCCTTGAGGGCCCTATGAATGAGAAAGTCACAGATTTGGTCAAGTCTGGT CCACTATGTGTCTCATTTGAGACCTGGTGTCTCTTTTCCAAGGAGGACTCCACACAGGATTTTCCAATAC TTACTGCAATCCCACGGGCTCCAGCAGGTCCTGAGGGACCCATAGGACCTTGTGCACCCTGTTAAGGGGA GATCGAGAAAAGCGTCAGGGAATGAAGTGTCAGGACATGAAACCCCTCGTCTACATCTGCCTCAGGCCCA GGAGGCCCCAGACCCAGGGGCTACCTCTGGATACTCAAAACAGGAAAAGCAAACACGGAACACTCTCTAC CACTTGGTCACCCTCTTCACTCCTAAACTCAGGATACTCACAGCCTCTCCTCTGTCTCCTTGTTTGCCAG TTGGGCCAGCAGGACCAGGAGAGCCTGGGGGCCCAGGAGCTCCAGGGGCACCCAGTGCTCCAGTCTCACC ACGATCTCCCTGTAGGAGCAAAGTGTCAGATTCAGCAAAGAATGTTTCAGAAGAGGCAGGCAGAGATACT TTGTTTCTAGAGTGGCTCATTAGGCCCAGCACAGTTCCCGGAACCCCCATCCCAGACAGACGCCAGTCAC TTACCTTGACTCCAGCTGCACCATCTCTTCCAGGGGGTCCATCAGCACCAGGGCTGCCCTGGACAAGGGG ACATGAGGATTCACTTAGAGCCACTCTCTGTTTACTCTCCCACTCTGGTCTGAAGCATTGACCTGTGCAC TTCTGCCCAACTGAGACTTCGGGGCTAACACGTCCACCAAGCTTCCACCCACCCTCCTCTTTGTACACCC AGCCCTGGTCTCTCTGGGTGTCCTTCCCTCAAGATCATCCTGCCACACCAAGCCCTAGGGCTCACCTCTC GTCCAGGTTCACCTGCAGGCCCTGTCAGGCCAGGAGGCCCCACAGGACCAGGAGGACCTCTGTCTCCAGA CGCGCCAGGTGCACCCTGCTTGCCGGGCTCACCCTGAAAGGATGCAGACAAGGACCATGAACACACATGC TAAACATCCCTGCCAGGGCTCCACCCCACCCTCTTCAGCAGAATCAGCCAACAAAGGGATGCTCCCAAGG GTGCTGAGCTAAAGGAAGACCTAGGGTACCATTGCAGCAAGAACACCCAGTTAAGAGTTTTGAGCCTGAA AAGCATCCTTCACTCACCGATGGGCCGGGAAGGCCGGGGAATCCTCTCTCACCACGCTGACCAGGCAGAC CAACAATGCCCCTTTGACCAGCCAGCCCCTGGGGACCTGGAGGACCATCAAGACCCTAGGAGAAGAAGAA AGAGCTGACACAGGGCTTGGCCTGGCTGTGACTCTTCCCACCCATTGAGTCCATTCTGTGCGGCTCCCTT CCTACAATCCCCCACAGCCCTGCACCCTCCTCCTAGTGCTTAGAGGAGCTCAGGCGACACTCATAGGCCT AGCAGGGGACGTACAGAGGGACCATCATCTCCAGGTTCTCCTTTCTCGCCAGGAGCTCCTGCAGGACCTT GAAGACCGGGGTCACCAGCTCTGCCAGGGGGGCCACTGTCTCCTCGAACACCTTTGGGACCATCTTTTCC AGCAGGACCAGGGGGACCGGCGGGTCCAGGATTGCCCTAGGAGGAACAAATACAGAAAGTGGTAACTTGC CGTCCTCCTCATCCAAGTTACCGAGGCCACTGTGGCCTTGGGGGCCAAGGCATTCCACACGGTCCACCCC TGTGTAAAGCTCTGAGCAGCTAGCTGTGGCTCCATAGTCCTTGCTTAGCCTTTCTTCATCCACTTGGAGC TTTTCCTGCTGGATCAGCTTCATCCTCTATGACAGATACCTCCAGAAACAGCTCCAACCTTGACGCTCTG ACTTGAGTCTGCTGTTCACGCAGCAGCCCCTCCTCCACTCTCAGTGTTGATGGATGGAATTTTTCCTTAT CTCTTCTCACACTGAAGTCCCCCCCTCCGCCCGCCATTATCTGGTCTGGGGCTCATGGGCTTCTTTTACA GATTGTAGATCTAGATGCACTGAACAGGTTTAGGAAATATGTCCCAGGTGCAGGGCATCATGCCAAGTCC AAACCAGCCAGGAAGCCCCATTGCTCCCAGCTACCAATGGTCAATTTGGTAGGAATGGAGAAAAGTCAGG GCCATACGGGAGCTCTTTTGACCCCTATGTTTGGAGGTTTGCTCCAAATGCCTCTGACCCTATCTGGGTC TCCCACGCCAGAAGTAACCTGGAATGGTACTCACATTAGCACCTGGGGGTCCAACTCGGCCAGCAGCTCC AGGGAATCCGGTGGCTCCCTGTGGACACAGAGCGGTGGGTGAGAGAAAGGCCCTGGATACCTCGGGTTCT CAGCAGAGAGCAGAGTCAAGTTGGTAGGACTAGAGAGCTTGTTTCAGAGCTGGGGAATCAAGAAAAGTTG AGGACTACAAAGTAGCAAGTGAGTCACTTGAAAACAATGAACACTGCACCTGGCCACATAGTCAGGCATG GGGTCGGGGTGAGAGGTGTGGCTAGCCTTCAGGGAGCTGAGTGGCAGAGCTGAGGGCTGAGGACTCTAAA GTGACTGTGCGCACACAGCAGAGTTAGATGCCGCCTCTCCTGCCAGGCTGTAGTCATGTGGGCTTAGCCT GGGCATGTTAAAGGCTGGGCACAGAGAAGGTGGAGAATCCGGAACCTAACTAACCCACTGCAGAAATCAT GGCCCAACGCCTTTTTACATGAGATTTACTCACCGGGGGACCTTGGGCACCTCGGGCTCCCTTAGGACCA GTCACTCCAGTAGGACCCTGTGAAAGGAAGATGACAATGAGGTCTAGTGGACCTGAGGAGAGTGGTAAAC ATCTGTCTGAACCTTAGCGCAGGACCCCTGAGAACCGGGCTATCAGAGCACCGCTTCCCAACACTAGGAC CCCAGACAAAAGCTATCGTAGGTAGATCTGTGTGCATCACCACCGGAAGACTCTAGGGCTGGACTCTGTA AGCCTTCTACAAATACAACCCCAAAGTCTCCCCTCCTGGGAAACCCACTCTCTCTGCTGCCCCAGGATAC CAACTGCCTGTCCTGGCCATCTGAGGTCAGTGGACACAGCCTATACTCAGTGCTGAGGACCTAATACCCA ACCTGCGTGCCCCACGCACCATTGTCCCTGCACAGCCGAGGTGCCCACGAGGCTCCCAATTAGACTCTGC CTGCATGACCTCCCAGGGTCCTCCTCCTGTCCTGGCAGGCTCTGCCTCATGAGCTCAACAATACTCACCT GTGGCCCAGGGGCTCCCGAGGGGCCTTGTGGGCCGGGGGCACCAGCATCTCCTTTCTGTCCGGCTTCTCC TTGATCACCCTTGGCACCAGGCTGGCCATCAGCACCCTGTAATAGGAAGAAGAGACAGATGAAGGAGAGG CAAGCTGATCACCCCAGGTCCTGCCAAGAGGTTCTGGGAGTACATGTGTACGCGTCTACCCTGGGCCTGA AAACTGGGTTTAAGACTGGGCTGTTCTGTTGCCATAGAAATATGAAGAAAGTCCATTTCTCCCTTTACTG CCCTCTGGCGCCCCCTCCTCTCTCCCACCAGAAGGTGCCCTTGAGTTCTGGATGTGAAGTCAGACTGCAC ACATGGGTGGGAGTAAGGTAGACAGAGATACTCACAGGAGGGCCAGCGAATCCAGCAGGTCCAGGTGGCC CGGTCTCTCCGCGTTCACCCTGTAAGATGACCAGGAAGTGTCATGTCCGTCGCCTGCCTCTGTGCTCGCC TCAGACTGGGAACCCACTGCCCAGCCTCATGCTCAACCCCTCCCAGAGAGAAGGCGTCTGAGTGGCCTAG GTCCCGGGGAGTCAGAGCACTGGTCATGCCTGGGCCTGTGACCTCTGCCTTTCATGACTTCTCTCCTCCC ACCCCTAACCTGAAGGGCATGGCTGGTTTCCTCACTCCTGGGGCCAGGGAAAGCCTAATTTAGAGAGACA CACTCACCGGGGCACCTCGAGCTCCGGTACTTCCTGACGGGCCAGGAGGTCCGACTTCTCCCTAGGAGTT AAGAAGGTAGGGATTAGAGTGGGCCCGAGGACCCAAGTGTACCAGGAAGCCATGATGTTGGGAAGAGGAC TCTGGGTCCCTAGACCCCATTCCACATTAGGTTTCTTCCCAGTCCCAGCTGTCCCATCTATCTCTTCAAG GCCTTGGCCAATGGCACCCTTCTACCAGGCCAACTGCCACACAAGTCACACGTTAACTGGACCTCCACCC TATACTTCTACCACCACCATGGTAGGCAATGGCCAATGAGTGAAATTTGACTGTCTGGCAGGAGGTAAGG GGAAGACATTCTGGGGAGGTGGACAGAGGGATGAAGGTCAGACAGAGGGACAAAGGCCAGCTGCAACTCA CCTTCTCGCCGTTGGCCCCTGCTGGGCCTGGGGGTCCGATGGGCCCAGTCAGACCCTGGAGGGAGAAAGA TGGAGATAAAGGGAGAGAGTCAGGCCAGCATCATGGGGTTCCTTGGGGATTCTGGGAGCCCCATACCCAA TAGACTTTGGTGTACCCTCCCATGGTCTGAGAGCTGCCACTGATGTCTGGGCCCCAGCTCTAAAGGGAAA GCCCCTGTCGTCTTCCAGCCCCTCTTCTGAGTGTGAAAGGTCGTGGGAACACCTGTGTCTGTCTCCCAGC TCCTGAGTCCTATAAGCAACAGCTACTTACTCGGCCGCCATCCTTCCCAGGAGCTCCCTCTGGGCCTTTC TCGCCAACATCGCCCTGCAGAAGAGAATACCGGGTACCTTAGTGGGTACATCAGGAGCGACTGCCAGTTC ATCCCCGCCTGGCTAAGGTTCTGGTATCCTGTCCCTGCCTTAGGAAGTCTTTTCTGTGGGCTTTGGGCTG GTGACAAGGGGTAACGGGTGAGAAAACAGGGAGAAGGAGGTCATGATGGCAGAGCGGTTCGGTTGGTTGG TTGGTTGGTTGGTTGGTTGGTTGGTTGGTTGGTTTCGGGGTAGGGGTTCCTAGTTTCTCAAAGAATGGCC ATGATCCTCATCTTCAGAAGTACAAGGACAGAGTATGAAGCCTGGTGGTTGTGGCGTTGGGGAGAGACAC CCATCACTTACTCTGTCTCCCTTGGGCCCAGCAATGCCAGCGGCTCCTCTCTCACCAGGCATTCCCTGTA GACCTGGAGGCCCCTGAGCCCCAGGGGGGCCATCTGGGCCAGCTGCACCCTAGGATGACAGACAAGAGGA CTCTGTAGGGAACGGCATCTCTCTCTCTCTCTCTCTCTCTGCCCCAGTGTATACAGCCTGGGAAGCCAGG ATCCCAAACCCCTCTTCCCCCTTAAATCCCCTTCCCAGTGCCACCTCCCGCAAGTTCCTCCTAGCCACCA TCTTTCGTGCCCCCTCCCCTCCCTCTCACCCCTCAGTGAGCTTCCCTAGTGCTAGGTAGAAGACACCCGC GGGACTTGGCCTCACTTACTTTGGGACCATCAGTACCAGGAGTGCCAGGGAGGCCTCGGGGACCCTGAAG GCCCTGAGCACCAGGAGAGCCACGTTCACCTGGGAAACCTCGCTCGCCCTGTGGAAGAGACATCAAGCAG AAATCAGGCAAAAGTGATGGAGACGATGAGACAGGGGAGGGGCCCACAGGAAGAGATATGGGTCCCCAAG AACCCAAGGTGGGCTGCAGTGTTGGGAGACATGGGCCAAAATGAATGAAGGCAGGCCCAAGGATATACCA GTGCCGGGTAGCAGGACACTCACCCGAGGACCCACAAGGCCAGGAGCTCCAGCTTCACCAGGAATACCCT AGAGAATACAAAAAAGGATGTAAGAGTGAAGGCTGCCTGCTCCCTCTGGACTCAAGAGCGTGCCTCCCAT GGTGGCTGAGCATGTCCACAGGAGGACTGGGCTCAGACTTGTCCGTGGAGAGCAGGGAATCAGGTCTGGG GCATTCCCAGGCTCCACAGGGCTCTCCATTCACTCCATTTCCCTTGTCTCCTGTACATCAGCTAAACAAG GTCACAGAGCTCCCAACTCACCTGGTCACCTTGCTTTCCACCTTCACCTGGGGGACCGGGAGGGCCAGGA AGTCCCTGAAAGCCAGAGGGACATGGATTAGCAAAGAAGGGTGTCTGGTGCCTCAGCTTCCAGGAGGGCG CAGCACAAGGCAGACCCAAAGGAGAGAATTATTAAGGCCAGGCACGGAGAGCCACACCCTCTGATACCCC ATGAGAGGAGTGGGCTTGCCACCCTTAGTGCCTGCCCAGAGAGCTCTAGGCATAGGAGGGGATTGCATAG AGAGTCTGGTCCAGCCACCTACCTGGAACCCTGATGGTCCAGGAGCGCCCTGCTCGCCTCGTTCACCAGC AGGTCCCTGCAGAAGAAAGAAAAAGTGAGCCAAGCCAGGAATTCCAAGAACCTTAGGCCCCGGGGCGTTG ATTAGAAGCCTTCCTGCCCTGACCAACCAACACGTGGCAGGCCACTTGCTCTCCATCATCTACCCACACT TCCCTCCACTAGGCATGTCCTCTCATCTGGGGATAGTTCAGCCCAGATCCACATCTGTCACCTCTCCTAC TAAATGGATCCAAGGTCCCTCGTTTTAGCAGCAGGTACTCACACTGGGGCCGGGGGGTCCTGCGGCTCCC GTCTCACCGTCTTTTCCAGGAAGACCCTACAGGGCAGAGGAGGAGGAGTTGTAACGACTGATGTCTGTGG CGTCATCTGAGACCAGCAGATGTAGTTTTCCTTCGGTCAGGGGTTTTTAGATCAACAAGGTCTGCAACGG CTCTCCGCTTTCACCCTTCCCTGAACTTCCGTGGTGCGTCCACCATTTGCCTCAGTCTTTCTCCACATAG ACATCTTCCTCTGTACCTCAGCCTTGCCTCTGAAACCCACCAGCAGCCATAGACTGTCTGGGTGGATCCT GACACAATCTAACATGTGCTCATCCACAGAATCAACTCTTGAACGTCCTCCCCACCCCCCCGTTGCTTCT GTGAGGAATTCCACCAACACTAACACTGCACCAATAACAAGCCATAGGTAGTGGGGAGGACACTTACTCT CAGACCAGGAGCGCCAGCCAGACCCTTCTCACCAGCTTTGCCAGGCTCGCCCTGAAGGGAGGGACGAGAA GACCATGAGCTGGGTGATTTGGGATAGAGTGAAGTAGTAGGCTAGAGAGCTGAGGCCTGAAGCCTCAGTG TGGTGCACAAGAGAAGGTGCCATCGAACATCAGCCCCTTCTTTTATAGTCACTGGCCTCCGGGGCACAAG GCTCTATGGGTAATGTTGCAGTGCTGATATCTTAGGGTTTTAAGGTACCCAAGTTTACCCCAGGTCACAT GCATTCCTTGCAGGACATGGAGGACAGAGCTTAATGACATTGAGAGGCCACTGGTCACCCACCCTGGGTT AACTCTGCTCAGGACCCAGCTCCTTCTCCTCGAAGGATATAGGGAAAGACGAAGGAGATGAGAGAGCAAA CTGTCACTTACGTTGGCACCTTTGGGGCCAGGGAAACCCATGACGCCAGGCTGCCCACGAGCTCCCTGAG GACCAGGAGGTCCAGGGCGACCGTCTTCACCAGGGGCTCCCTGAAAGACAGGATTCATTCTCAGGACATA GTCCCTCTGGCTGTATCTCCCCATCACTATTTACTAAGTGTGTGCTGTGTGGCAGGCAGGGAACTAGGTA CCAGCCATACACATGCATCTAGGGTTGACCAACCCCACACACAGACCCAGCTACGGGTAGATGTTCCTGG CTCAGAAGTCTCTCCTGAACTTCTAATCTTTGTCATCACTCCTCCTCCTGGAAAATGTCCAAATGCTGTG TGTGTGTGTGTGTGTGTGTGTTTGTGATTTTCAGAGCTCAGAGTATAGGTCGCATCTGGCCATAAAACCG ACCATGTGTCTCTTACCCCTTCACAAAATGTACAAAGTCCTAGACTGCCCTCACCCAAACTCCCTTCTCT CTTCCCACCATCTACTGGACGATAATCCCTTATTTATCCTCCCAGGAACCTCACTCAGGCTAATAGACTT ACAGAAGGACCAACTTTGCCTTGAGGACCAGCGTCACCAGGGCGACCGGTAAGACCCTTGGTTAGGGAGA GAGAAGAGACCAAGGTTATTCGGGGTGGGGGAGGGGGACAGGCCCCAAATCTTCCAATTCAGGCAGCACA GCTTAGAGGATGCAGGTGGGAAGGGTGTGGGGGTCTGTGTAGTATCCACCTTACCCTGGCTCCAGGAAGA CCAGGTTCTCCAGGACGACCCGGGTCACCGTTGGCTCCCTTGGGACCAGTCAAGCCACTGGGCCCTCGCT CTCCAGGGGCACCCTATACCAGAGGAGACAGGAAGTCCATGGGATGCTCTGTAACTAGGGAAACAGGCAG GGACCAGGCCTCTCCTCCTCCACTCACCTTGGGACCTGCCAGACCATCTTGACCTGGGAATCCACGGTTG CCAGGAGCACCCTAGGGAGAAGGGACGAGGCAGGGGATGAGGATGCTTTTCATCAGCATGCCTGGAAGGA GTCCCACCAGGCTCCAGGGGTCTGTCCCCTCCACCTCCCACCACAGTGACTGTGGGGCGGTAGACACCGC CCGTGAGTCAGAGAAGCTAATGTCCGTCCAGGGCCTGCTCCCACCTCTCTGGGAAGAAGCTACTGTTTTA TGCCACCCTTGGGACAGAGGGTGCAGACAGCATGAGGATGCTGTGACCCTGGTGTTGGATGGGGAAGAGA AGAGCCACGTTATCCAGAAAAGTCATTGGGTGTGGAAGAAAGGATGAGCCACGGAGCAGCGGGCCTGTGA GCTGGAGCTCCTTGCCTACTTACTCTCTCTCCAGGGGGTCCGATTGGTCCAGCACCACCCGGCTCTCCTC GAGCACCTCGTTTGCCTTCTTCACCAGCGGGGCCAGGGGCTCCTTGGGGCCCAGCAGGTCCCTGAAGACA AGCACAAGAGGGGTGGGATGAGGTTTCCACCTAGCCTTGGGGAAAGCACTGGCCTGGTGTGCAGAGGAAG GGGCCTTGGAAATGTTTCGGGGCTTGGCCAAGGGGGTTAAAGGGTCAGCCATTGGGTCTGGGGGCCAGAA ACAGCCCAAGAGGAAGAGATGGCTTGGAACTCAAGCTATTCGAACCAGGAGAGGAGGCTGTGTCAGGGTC TTCTCTACCCTACTTCACTCCCTTCTCCAGGGACAGCAGGAGAGAGCCCGGGATGGGAAGTGGCTGTGGG GAGGGGGCACAGCGGGGGCAGAAGGGTGACCTGTGGGCAGAGCTACAGCAAAGAAAACAAAGTCTTGAGG GCAGATACTCACAGTCTCTCCCTTGGGGCCTTGATCACCTTTAAAGCCAGCAATGCCAGGTTCACCCTAC GTGAAAGAAAGAAATATGCTCGCACTGGCTTCTCTCCATAGAGTCTGCTCACCCTCCTCCCAGAAGCCTC CTACGGTGAGCAGGAGGGCACAGAAAAGAGGAGCCTGTAGGTAGGACCTGCCAATCTTTTTGGGCTCTTA CCGCCTGACCTTTGGGGCCAAGGGGACCAGTTGCACCTTGAGGACCGGGAGGGCCACGGGGCCCAGGGAA GCCAGGGGCACCAGCAATTCCAGGAGCACCCTGTCAGCATGAACAGAAGAGAGGCACGTGAGGAGGATGA GGAGGGACTAAGCCACCTTGGGAACACAGCCCAGGGACAATACTTACAGCGGATCCTTTGGCTCCAGGAA TACCATCAGTCCCTGGGTTACCCTGACAAGAAGATGGTATAGCGATAAAATAAACAGCAAAGAAACAACC CAACCATTCGGCCCATTGGGCCCCAGTCTAGGGGTCAGGGACAAGTGCTGTCTGCTTCAGGGGCATCCCT CCTGCCTGTCTCATGGGGTGGACTACGGGTGAAGGGAGACAGTCGTGGATGTCAGGGGGAGGTGTTTGGC CAGCATGACCATTTAGTGGTCCCAGTGACTGGGACTCCAGGTGACATGTACATTTGTGACAAGGCCACAC ATGCCATGCCTTCCAGGCCAAAGAGATGAACTTACAGAAGCACCTGCAGGCCCAGGGGACCCAGGATTGC CAGGCTCGCCACGAGAACCTTGAGCACCTTCAGGACCGCGAGCACCAGTGGGACCAGCTTCGCCCTGGGA AGAGAGTGGGGGGGCTGAAGTGGGGGTGGTGGTGGCAGCACTTCACGGCCCAGTGTGCTTGACTCTTGTG TGTGCTCACACTCCTGTGAGTGAGTTGCGTATGCATGGGGGTCTGTCTTTTCTGTTCCCACCTGACCAAG CAGCATGAAGAGCCGATATCCCACCCCTGCCTCTTCTACCCTCACCCCTGCCCTGTGACCCCACACACAG CTGCACAGATAGATGCCTACTGCATTCCAGCAGCAAGCAGCTTGCTGGTCCTTCAGTCCAGCAGAAAAGC CTGGGTTAGGAGACCTGCCATCTTAGGGCCATGGGATGATGGACAGATGGGCCTCCACTCCCCCTTCCCC TCCTTTTGTTTTCTCTTTGACAGAGGAACAGAAGCCAGAAGGGTGACTCTGTCTCCTCCAGAGCCTCAGC TCAGAAGTGGCTTTCTTTATGGCTGCTGGGTGATCAGAGCTGCTCCAGGCTTGAGCCTCAGCCTGTTTGA AGTGCCAGGAAGCCAGGGCTGAAAGCAAGCTGAGACAGGCTCTACTTTTCTTTAAGTTAACTGGAAGCCC CTTATCCCCCATGTAAAAATTCTTTTTCTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT CTCTCTCTCTCTCTCTCTTCCTCTCTTATTTTTCTTCTTTCTTTTTCCTAAAAGTCACAGCTCTGTGATC TGGCTCTCTGGACTGGAGCCTCCTCCGGGGACGGCTGCTGCCCTGGAGAGAGGTCAGAGCCTCCTCAGGT TTCTCCACACTGGCATTCTTACTTCACTTTGGTAATTATTATTTTCTAAAGGTCAGGCCCCCCTCACCTT CCGCTGTCCCTCTTCACAATGGGTCTCCTTCACAGGGCTCCCAGGGGCCTCAGACACTGTCTGGTTGCCA TGGAAACCCCCAGGCGTAGAAAAGCAACCTGATGCCAGTGACACAGGGAGGCTCCTTACTCACTCCCAGG GACGTTCACACTGGAATCCCTCCCGGGCCACAGGGGCTTTTCCTTGAGCCGGCTGGCCTCCCGCTGGTCT CTATTAATCCCTGGAAGGACCAGGTTAACAACAGCCCAGCACCCCAAGTGAAGTAGAAATAAGAAAGGGG CAGGGGATGCACAGAAGAGTCGCCTCGCCTCTGCCCCTCCCCCTCTATCCCTTTAAGCTCCTTCTGGGTA CCTCAGCTTTTGCCCACCCCCAGGCTTGTTTTCTTCTTCCTCCCCTCCCTTAGTCTTCTTCTCTCTCTCT CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCGGGTCTGGGGGGGGAGG GTTCCCATCTTTGACTACTAGGTGGACTTCAGCCTCTACAACCGAACCAAACTCTGTCAGAGAGAGATGC TGGAAACACACAGAGAGGCTAGGGGGGATGTGTGCCAACAGGAGCCTTCCTTAGCAAGGACCACAGGAAG ACTGGGTGTCCTGACCCTCTGAGATTCTCAGCTTGACCAGCAGATCACTCACCTTGGCACCAGGAGCACC AGGGAAGCCAGGACCACCTGCGGGACCCACAGGACCCTGGGGAGAAGAAGGGGACAGAGGGTGAGCGCTG GGTGTCAGTGAACTCTGTCCAGGCCTCAAAGAGAGACGCCCCACCTCCCACTCCTTCCACCTCTGTGGCT AGAAGAAACTGCCAGGGCTGCTCTCCCCAAAGACCTCCAGAGAGACACCCTGCTCCTCTTGGAGAGTTTC TGAGTCTGTGAGAAGCCACGGGGCTTTGACCTCTCTCCTTAAAAGAGGAGACTGCTAGGGGCAGCAGGGG ATGTCAGGCTGCAGTGTCAACAGCATGCTCACGGGATGAGCCACCTCCTTCCTGCCACAAAGTACAGGGG CAACCCCACAGACTTCAGGGCTGCACAGCTACTGTCACCTGCTTAAGAAGGACAGCAACTTACCGGAGGT CCAGCGGGGCCTGGCTGGCCATCGTTACCCCGAGCACCCTGTGAACAGCAATAGCACAAAGGAGCCAATT AACACAGTGTTGGGGTGTCCCAGGCTGAGCATGAACAAAGCAGAGGAACCTTCCTGGGATATCTGTACAA GGGGGCAGAGAGACAGACAGAGAGAGGGCTACAGGGCACTGGCCCTCGTGGGTAAGGAAGCTTGGGCAAC TTCCCAGCAGACCTGTCACTTCTAAAACTTCAGTTAGGTCCCCAGTATTCCCGACTTGAAGCTGAATGAT CATTCAAAGAATCCTGTGGGCTGGGCCAAAGGAACCGGACAGAAGGAAGGAGGAGCCTGCCCCTGTGCTG GGTATCCTGGCTTAACAGAAGCAAGTCTTCTCTACCCTCTGGTCCCTCCCAGTCAGCTGCTCTTCAGGAC AGCACAAATACCCCCACAATGTTCCCTGCTGACCGGGAACCTGACCCGCGATGAAGACAGACCCTGTCTA CAACCGCGCCTGAGCTCCTATCTCAGAGACCCTTGGCTTTGCAGGGGTGGGGGTGGGGGGTGGGGGTGGG GTCGAGGTTGTCCCTTCTCTAAAAGACTCGAGCTCCGAGAGTTCCACTGGTTTGGGGTGAAAACATCTTT CTATTTTTCTCCAGTGCCCTTGAGAATTTGTACTCTAACTCCAAGAACCGCTATGTTAGGCACATCCAGG TCTAGGACTGGGTCCCTCCCAGACCCAAAAGGCTAAGCCAGTGGCTCTCAGCTTTCCCAACACTGTGACC CTTCAATACAATTCCTCACGTTGTGGCAAGCCACAATCATAAAATTATTTTCATCGCTCCTTCACGACTG TAATTTGGCCACTGTTATGAATCATAATGTAAGTCTTTTTGGAGATAGCGGTCAGCCAGGGGAGTCACAA CCCACGGGGCTAAGGGGGGACTTTCTGCACGTCTCTGACTCTCAGAAGCACAAGGCAAGGATGCTCTGCG GTGCTCAGTCTCCTTCCTGGTGTGAGCCATCTCTCTTCCCAGAGCCTCTAGCCTGGCAGCCAGAGGGAGG GGCATGGCGAGACAGCAAGACTCAATAGAAGGAAGAGAGAAATCAGAGCCTGATTTCCTGACCCAAGCGC CCTGGAAAACTCTGTTACTGGGGAACCCTACAGTACCTTCCCTCCAGGAGTCAGCAGAGAGCAAGGCAGG GGGAGAGGGCCCAGTCTGAGCTGCCTGTGTCTGAGGCCTACATGGACAACTTCTAGGCTCAGAAGGCCTT TGGGAGTCCTCGCAGCAAACAGCAAGGCAGAGTGGGGAGCCCCGCCCCGCTCCCACCAAAAGGCCCAACA CACATGTAGAGAACATTCTAAACAGAATCTCCTAACAGCGCTGCCACTGCTTTGTGGACGAGACCACCAA GGAAAACCAAGAACTGGGGCTTGTGTCTGGGAAGAAGGAGAGACAATGCGAGAGGCAGTGAGTGAGCCAG TCTGGGTTTGAGCCTCGTTAAAATCCCCAGGCCAGGGTCTCCCGACTCTGCAGAAGCAGCAGGCCCAGAG CTTCCTTCCTTTCATACAAAGCGCCCCTGGGGCGAGGCCTTTGGCCAGCTCTGGTTGGCAGTGCGAGTGC AGGCTGCTGGTTTCACAGACCTGCTCCTGAGGGAACTTTCCCGCCCAGATGCACGGCCTGGAAAGCAGCT GCTTACAGTTGCCCTGCAAGGACCTAGGAGGAGGGGCCTCTGAGCTTGGTTGGCTGGGTGTAGACCAATA GAAAGCCGTAAAACTTGGTTGGCTGGGTTGCAGACCAATAGAAAGCCGGAATCTTTCTTAAGCGCGCCGT TCATCACATCACTCGCCTGACCAAGCACCTACAAGGCTTCTCTATTGCTTGGGGAGCCAAGATAACGGCC TCTCGCTGGCACCCATGCCCTCCACTGCCTGCCAGTCCTTTAGCTCATGGTTCTGGGCCCTCGGTACACA GTCTGTCTTAAGCTAGTTATTCTTCCCCGGGGACTCAGTTCCCTCTTCTCTAAAATGGGAACGAGAGATT CAAGTTCACAGAATGAGGGGGAAGATTAGACAAAGAGAAGCAAGCCAGGTTCTAAATCAAGGGTCACGAG GTGGATGCCGCTGGTGTCCTATCTCGACACTACTCAGAACCGCATCAAGGGCGCGGAATCGAGAGAGAGG GCAGAGTGTATAGCATAGAGGGCTGGCACCATCTAAGCCTGATCCTGAACTCTAACATGCACGGCTCAGG AAGGAGCAGAGGCTATTGAAGGGGTGACCTGAAGGATCCCGACTCCGGAAGAGGACTCTCACCAGCATAC TCTCCTATAGTACGCCCTCCTTCCACCCTGCAGGCCCCACCCCACCTGAAGATTGGGCGTAGGAAACCTC AGGATAGAAAGTTCTGGTATGATGATGCGCCCTAATCCTCACCAAGTTGGATTTTGTTGTTTATTAGGTA TTGGGGGGTGGAGTGTGGAGAAAGGTCTTATGTGTGGCGCAGGCTGGCCTTGAACTTATGATTCAGGAAC TCAGCTTCTTGGGTACTATGATTATAGATAGGTACGTCCCTCCTGGCTGGGGTTACCACTGAGTTGATTT GAGGGTCAAGAGAAATTTACTTGTAAGCTGTAAAGTGTTGAGCGTGTGGTGGCACCGGGCTTTGGGGGTT ACTCACAGCAGCACCAGCAGGGCCAGTCCGTCCTCTCTCACCAGGCAGGCCACGGGGACCCTGCAACACA CACCAGCGCGGTTTAAGTGTGAGTTGGCATAATGATGGTCTGCGTCATGACTTCTTCCCACCCACGGTGG CCCCATCTCGACCCTAGATCCTGCTCCCAGGACACAGGGGTTCCTTCAGGGAGACCCCTGTGTCTTCCTG CCCCTTCCTATGGAGAATGCAGCTCGGTTCTCAAAACAGATGAGTCACCCAAATCATTGAAGACAAACAG ATTTTTTTTTAAGAGTAACTGAAATGTGCTTTAAACGTGCCTAACTGTTCCTGTTTCGAGGAAGGGCGTG TGAAATGTTGAACAATCTACGCTGCAGGTTGGGTTGGCTCATAATCGGATAAATCTGTGCGAACAGCTTT GCATGAGTGCATGAAGGAGGAAATGCTGCTGTTTGCAGGGTAGCTGTCTGACAGGTGTTTCGGGAGTCTT AAGAGTGTGGGGTGGCTTCCCCAGGGGTGACTCTCATACTCACCATTGGGCCCGGGGATCCGTTCTCACC AGGGGAACCACTCTCACCCTGGAGAAAGAGACATATAGGGTCAGTGTCTGGAGTCTTGGCTTCCAGAAAC TTCCTAGGTAAGTCATCGATAGGTCTGGCTGGCTCAATTAGGCCTGAGACATGTCAATTTCAGTCCGGGG AGAGACGATGTCCCCAAACTCTAAGGCCTGCTGCTCATGTACCAAGATGTAGACTGGGTGTTCCCAGCTA TGTTCTAACTCCCGACCCCATCAGCGCCGCCTTGACTGGACAGTTGTCCCCTACCGCCACCCCCTGTGTG TCTTGTGGCCCCTTTACCTTCACACCCGGAGCACCAGCTTCCCCCTTAGCACCGTCGAGGCCTGGGTAAC CCTGGGAAACAGGACGAGGGTTCCGTCACATGTCTGGGAGCCCACCCAGGAAATAGTGTGCATAACCCCC AAACATCCTATCCCATGATACTTACTCTGTGACCCTTGACACCGGGGAGACCCGGGGTTCCTGGGAATCC ACGAGCACCCTGCAATACCAAGAGGAGGTACTCAGAGGAAAGCAGAGATTGGGTGAAGGCTGCTGGATAG ACTGCAAGTCCAGCTCCCTCAGGCCTACAGAAACAGGCATCCAGGTGTGTCCACAGCTCCTTCAGCCCAA CCCAGAGCATCACCTTGTGATCATACAAACACGGTATCCAGCGTGAAGGCATTACGTACACAGTACCGTT AGTACCGTGAGCTAACCAAGACGAGTGAGCCATATGGACTCAGAGGGAGACTGGAAAAGCCTGTGAGAGC GAGGAAGATGAAGCTTTACCTGAGGGCCAGGGAGGCCTCTTTCCCCAGACTTTCCGGGCTTCCCAGCTTC ACCCTGAACAGAAAGAGAGGCATCTCATTTTTCTTGGCAGTCTCTTGAGCGTATTCACTCCACGGCTGGG CATCTGCCTATCTGCCCACCTTGACCACGCCCTTCCTGCAGATGCCCGTGACCCAGAATGCCTCTGTGGT TTATCCCTTGGCAAGTTCCTGGGCCCTCACTCCACTGTCCCCAGCAAGCGTCTGGTCCCCTCTCCAGAGC CCTGTGGACTGGCCTGTATGCCCTGATCTCCAGAGGCCTTGCTGTGTGCTGCCAGTCATAAAAAAAAGCT CAAGAAAGCCAGCTCTTCTCTCTATTTTTTTATGTCCCCCTCCTCTGTAGACATTCTGGCTCAGGCTGAG TTTGTCTATCTCATTTACAATTGAGATGATGGTAGCCTGTTTGTTGACCGACTCTTGCTTTGTTTTTCTA CTCTATACCGCTGTGCTTTGAGTCCTCCCATCCCGGCTGGCTCTCTCCTTTCTCATTTCTCTTCCCGAAG TTAATGATGTTTTAATTACTCTCCTTCTTGTGGGATCTAAAGGGATCCCCAGGGATCTGGCAAGCTGAGA TGCAAATAAAGGATATGTGGGTGGTAGATAGCTGGAATTTAGGACTGGCTAGCCTGGTTCCTCAGGACGT CTCTCTACCCCAAGCCCCAGCACATCCTCTCTCTGGGTCTGGGGCTTCTTGGGTCTACTCACGTCGTCAC CAGGTTTTCCAGCAGGGCCAGGAGGACCTCGGGGACCCATGGGACCCTACAAATAGAGAATTCAAGACCT GGTTGGAAGGGAAACACAACTCGAGGCGGTCGCTTTGGAAGCTAGTTACTCTACAAGGAAGAGAGACAAA AAGGTAGTAACAAAACTGTAAAGCAGATCATGGTGGGAGGAGGGGACTGCGCAGGCTGGCGACCCCTAAG GGGAAGTGTCCCGATGGAGTTCCTGCCATATTGATTCTCTGCCGTTGTGCCCCGTGGGTAAGGCACTCCC ATTGTGGGAAAGGGCTGGCAGAGCCTGGGAGCAGACGGTAGCTTGGGTAGAAGATTGTCCCCAGAGCCTC CTGGGAGAGGGTAGCCTGTGGTACTCACAGAGACACCAGGCTCGCCAGGTTCACCAGGATTGCCTTGAAA TCCTTGAGGGCCCTAAAAGGGGAAATAAGGACGCCATGTTGACCTCCAAGCTGTGCCGCCGTCATGTGGA TGATGAGCATCTACAGCGCCCCCAAGAGGAAAAGACTGAACACTTACGGGGGCACCGGCAGGGCCTGGGG GTCCACGGGGTCCCATGGGGCCCTGCATTGGAACAGAAAAAACGAGACGCTTACTGGCCCGCTTTATCAT TGGCTTCTAGGATTCCATCTTAGAAGAGGGACAAGAAGATAGTAAGGGAGCAGGAGGGGGAGGGGCAAAG GGACTCCAGCGGCTGCTCCCTCTTCTTTCCCACTCCCCACTCAACCATCTATCTTTATTTATAGGCCCCA TTTGGACCGAGACGCTGGCCTTGCTCCCTCCTGGATGGCGGCCATGTTTACTAAAGTCTGAATTTCATTT AGCATGTGCCAAGCCATCGCTGCAGGGTGAGATTTCCTGCTGGAAGCCTGGTGGATGCTGAAGAACAGTC GCTGCTGTCTGCATTCTTCAGTTCTCCTTCCAAGAGCAGTGGCAACCAGCCCCCTAATACATCGGCTCTG TGCATCACTCCGTCCCCCTTCCTCCTAGACACACTAGAGCGTCATCCAGACTGGCATCCATCACCATTAA AAACCAAACTCCCCAGGGTTAAATGAGAGGTTTCCCATAGCTGATGGAAATGAGATGCCCTAAATCATCG GCGAAGGCAGAGGTTGCTGGGTCTCTGGCTTTGCGAAAGGTGCCCTCCTCCCGTCCGGTCAGCACAGAAC TGGAATCCTACCATGGGCCCTTGCATGACTCCCATCTGGGCACCACCAGCCTTCTCGTCATACCCTCCAG CCATCTGAGCCGCGAAGTTCTGCAAAGCAACAGAGCCGTGTTAGGGGGCTGAGAGGCCCTGGTGTCATTC CTAATTGCTCGGAGTTCTACCTAGTCTCTGGTTATCAGGGACTAGCCGAGCAGCGTTGGTCAGAATTGCC AAAGGGATCTGACAACGTTTTGGGAGTGTGCCCTTGCGACAGTGGTAGAATCACTTCCTTGGAAAGTCAA GTGTTATTTGTGGTGGTCCCGGTCCCTCACGCTCTGCCTTATAAACGTTCATATTCTGAAACATTCATAA GTAAAACATCGCCTTTAAAAGGCATCCTTTGTTCTCTCTGATGTTGATGTCTGGCAAAGGGCTGAAATCT GGTCTTGAGGTATTTCGGGAAGGGTTATAGTAGGCGTCTGTGAACCCGCTTAAGTTGAAGGATTTAAAAC ACAGCAGACCTCCAAATGGCACACCTACAAAGTGGGCAGTCATATAATTTGTTGACTGGTGTGATTCCAA ACACGACAGTAGCCGCACACCTTCACTCAGTGGGGCTCTTTCATAAGAATGAATAGTTGCTTGCAATGTA CTTGGCAAGGGCTATGGACAAATGTCTTCCAAGGACAGTGGTCACTGCTCTTCCAGAGAAATACAAGTGC CCAGTCATTCTTTGCGGGCACCCCTACACCCTCCCCCAAGAATTAACCGCATGGTGGGGTGCCAGGAAGC CAGATAGCTGAAGGCCTTCTTTACAGAGACCCAGTGAGTGAAAGAAAGTCAGCCCTTAGCCCCCAGCGCC TCGAGCCTCATACACAGATCTTCCTTAATTACAGGCCGTGAACAGGCTGTGTGCGTACTGCTGGCTGGCT CTGGGAGGCTGCCAGGTAAGAGAGTAGCAATTTAGAAGCCACAGTTCTGGAGGGTCAGCCTGGAGAAAGG AGAACTAAGGGCACTTACTCCTGCACTAAGGCCAGGGGGACCAGGGGGACCTGGAGGGCCAGCGGGGCCA GGATTTCCAGGGGTACCAGGTTCTCCATCTCTGCCACGGGGTCCAGGCGCACCCTTGACAGGAAGAGAAA AAAAAGTTATCAGTGGAGCACCGCTACCTTTGGAACCATCTGCCCTGGGCAGCACTTGGGAGGTAGCCAG GCCTTTAGACGACCCAGGGGACACAGACATCAGTATTTGTTGCTGTCTGCTCACCTTTTCTCCCTTGTCA CCACGATCACCTCTGGGTCCTTGTTCACCTGCAGGTCCCTGAAGGTGAGGGGCAAGGTGTGTTGACATGA AACTAGAGGTCATGATGGGTCAGGGGCAGTCAGAGAAGAATGGAAAAAGAGATCTCTCCCTTTCTTACCT GAGGGCCAGGAGGTCCTCTGGGTCCTATGATCTGTGTCAGAGAGAGCCATGAGCCCATTGGTTAGAGGGG TGCATTTGGGTCAGCAGGTGCACGGGTTGTGGCGGAGGTGAGTCGGGTGGGGACGGGTCACGGTGGGGAT AATTTGTACTTACATCTCTGATATCTCCAGGTTCTCCTTTCTGCCCCTGCATCACAAAACATCGACAGGT GAAGGCTGAGCAAGCCCGCTGAGCCCCCACACAGAACCCCACCCCACAACCCTAGCCTCTCAGATGGACA TCTGAGGGCTAAAGAAGAGGCACAGACCAGATTAGTATCTCAGTACCCCTGAAGAAGGACACGACACATG AAAGCAAAACATGGACCAGTGAAATGGCCCGGTGGCTAAGGCTCTGACAGAGCCGCCCTAATGCCCTATG GTGGGAAGAGAGACCCAAGTCTTCAATGTTATCCTCGGGCCGCCACACATGCGCCATAGCACGCTTGTGT CCACGCTCATACATACAATCGCGTGGGCAGGGAGTGAGAATGTAATTAGATTAATTAAATTAAATTAAAA ATGGGGTGCCTTACCTTTGGCCCTAATTTTCCTGCAAGGGAAGACAGAGAAGGAGAAGTGAGACAGGGAT GATAATTTGACACTCAAACTCTCTTCGAAGGATCAGAAAGGAAAGGGCCACAACCGAGGAAGGAAGCGCA TCCCTCTGTCCCCGGAATCCCTCTGTGGTGGGGTTAGGATCACGGAGCCCTTTTGTGGCTGGGGACTTAG AAGGGACAGAGGTGCCTCTACCTCATTAGTCAAGAAGCATGCATAGTGTACAGGAATATGGCGGAGAGCA GGGGAGGAGGCAACCAGGGGTTGGAGGGCAAAGCGCAGAAGACCCAGAGGTCAGGCAGTCCTTCCCAACC CGTGCCCTCCCAAAGAAGAGTCTAAGGAAGCCAGCCTTACATTAGCGTGGAGTCTCCTTGACGTAAGCAC AAAAGAGAGCGGGACACAGGTGTTACAAAGAGCATTGCAGCCAGGGCCATCCCAGACCCATACGCCCCTC CCCCACCACAGCAGCAAGCTCCACTGGGTCCTCACACCGCACTGGTATGGGCGCCTCCCTCTGAGAATCT GCGCCATACCAGGCAACAGTGTGGGGGAAGCATGCAGGAAAGGCGACTTCTCGATTCCAGTTCAGCCCTC TTCTCCATAGGAGTAGGAAGGGAACCATGAGCCTGTGCGGGCATCCCCCACGCTCTCCGTAGGGAGATGG GACACTTGCGTGGGTGCTGGGAAGGGGTCAGCTGTACTCTTCTTTGTTAGCACTGGTTCTAGCTGGGAGT GGGTAACCACAGCAGCTTGCAGGGGCACGATCATCCTTTCAACTCCCAGAGCCCAGCTACCCCTTTGGCT TTTCTTAAATTAATTAGCCGACTTGACTCAGGAGGGAAAACTTTTGTGGAAGCATAATTGTGTTTCTGTA CGCATCCTCCTGGGGTGTTAGGTGAGGGAGGGTCTCTGTAGTGATTCAGGCTCACCAGCCTTCAACCTGG TGGAACCGAGAAGTGGCCTTGCCTTTGTGCCCCTGCTGGTGGGATCAAATAGATTGATTAGCAGCTTCTC CGCTTCAAAGAGAAGGCCAAAACCCACGGAAGGCATTTGCTGTGTCTCCGAGTAATTTATTTATGTTGAA TAATAAATAAATAAATTACGACCACTGGCAGTGGCGAGGTCAGCTGGGCAGATGGGACAGCACTCTCCGA AGGGGATCTCGGGGTTGAGGCAGTCTGGGTCTTCACAGATAATGTCATCGCAGAGGACATTCCCAGTGTC ACACACACAGATGCGGCAAGATGAGGGCTTCCATACATCCTTATCTTTATACCTCTGCCCATTCTGCAGA CAGCTGCCAGCCTCCTCTGCACCAAGTGGGGTGGGAGGGGCGGCGTGCCAAGCAGGAGCGGGGAAGAGCC AGAGAGAAAGAGAAAGAGGTTGTAATAAACTTGACATAATTAGTCCAAATGCTAGGGAATGGTGGGGGTG AGGTAGCAGACCACACCAGACAGGCTGAACTGACACAGTAGTTTTGAAAAACATAATTTGTCTTTCTATG TATTCTACAGTAGCTATTATGTTTTGCACTGTGCAAGACTGGTATGTTGGGTGGAGTGGGAATCGTGAAC CAGCGATAAAGGAGGGCTGTTACTCCATTATGTCTCTTCTTCCCAGCATTGGGGGAGGGGGAATGGAGAT AGGGAAGGGTAGTTGGTGAAACTAAGTGGCAGGGGGAGATGATGCTCTGAGCAGGAACCCTGGGGCAGTA AAGATGGAGAATACAGAAAAAAAAAAAATAGCGGGACACTCTAACTGCAGAGCAAAGACATCCTTTTTGT CATCCTCTAGGAATAACAAGATTTTCTAAATATAGCGACAACTAAGAATCAGAAAGCGCAGAGAATTCTA CCTACAAACGTTAGAAGACACAAGCAATACATAATAATCTGAAAGGCAGGCCGAGCCCTCGGGCTGGGAC GCTCCTGCCAGAAGTCTTGCCTCTGACTGAAGATGGCAGCCACAATATGGGTGGCAGAAGATTCTCAATG CCTAGTCGTGGCTAAGACTGACCAGTCTAGACCTGCGTTCTCCAAGAATGCTAAGAAGTAGCTCGGGCTG GACCCTCTCCACCAGCGCCCTGCCGTCTGGAATTCGCCCTGCACATGAGAACGGTGCTGACAAGAGAGCG CCAGGGACTGAAGAGCCCGCACCGTGTGCTAGGCAGCGCCCGGCGCTGTTTTTCTCATCAAAATCTCAAA AGCAGTGGCAAAAGCTGAGGGTGAATAATAGCGAAGAGCCACAAACCCAGTGGGCGTGGAGAGAAACGGG CCTGCCCTCTGCTCTTCAAGGAGGGCGAGAATCCAAAGATCAAAGTCTCCTTTTTCTTTTCCACTGGAAG AAACCCATCTATCTAGCCTTTAGATAAGACAATCGAGGAGAAGCTGAAGGAATCCCAGGGGGAAAAGGTC GAAGCTGCTGGGATACTCCCTGCTCCTCCACCTCAGGCTCCAATCCCACTTTCCCCACCCCCAGCGGCGC TAATATCGCTGGAGGTGAGGAAAGGCTAGTGACGCCCTGTCTTGACTAAGAAATGGCACTCTATTGCCCA AGACTGCCTAGGACAACCCGAGAAAATCCTGGAGAGGGTGCGTCGTGAAAGCTGATCGGGTTCCCCAGGA AGGGCGCCCTAGGGCCGCGCGGGCCAAAGGAGGGGCGGGTCTGGCCGGGTGTGAGAGCTGCTGGCTGACT CTTTGTGGCTGGGGCTCCGGACACAGCCCTCCAGCAGACAGACATCCGTAGAGTAAAATGTAGGATTAAA TGACTGCCCAAGAAAGGAGCCAACGCTGTAACCAGATCGCCTAGGTGCGGTCCGAAGAAGCCAGCACCAC CCTAATTGTGGCACGAAAGGGGCTACAGATAGCATCCTGGCCGCCCGATCCGGTTCCCCTCGTTACCGCC GTGCGGCATAAGTGATTCTTTGTGGCCGGCCAATTAAAAAGCTACCTCTTTCGGGGAACTGTTTTGCTTC GTCGCCGCTGTGCGCGGGGCTGGAGCCCGGGAGGTGGCGGCAGGCGGGCACGGGGGGTGGGGGGGGGATG AGGGCGGGGAGGCTGTGCATTGTGGGAGAGGGGGGTCGGGGAGTTGGGGGACCCACTGGGCCTTGCCTCT CATGAATGGGGCTTTTCTCAAGCGCATACAGAGCCCGATTCACAGCTCTCCACGAGGAACCAGTTTAAAT AAATACGGGCAGGGTTTCAGCCCATCTGGAAGCCATCGCTGCCAATCCCCCAACGCAAACAAGTCTCACA AAGGAGGACTGAGGTCTCCCCTCCCGAACCAGCAGCACTTTTGGAAGGCTAGGGCTGAGAAATGCAGATG TGGGTCAATGTCTTCGCGGCCAACAAGTTTCCCAAACTCGTGGAAAGATGGAGAGGAGGAGCGCGGTGGA CTCTAGGTTTCTGACATTCCTAACGTCCACACAGGCTACGCCTTGCCCCACGTCAGGTCTTTGGGTCCTG TGGATCCAAGGCTAGAGTGTGGGGTGTCTGCCATTGGTGAGGCAAGCTGGGGTGTAAAACCAACGATTTT TTTTGGGGGGGGGGGGCATGGTCAGATGCAGAATCGTAAGAGACCGAAAGTTTTAGACAACCTCCCCCCA CCCACCCACACTCATACAAAGCTGTGGAATTCACTCTGTCAAAAAGGTTGCAGCAGTGAGAGAGAGCTCT TTGACACTTAAGCGAGCGCCTCTGCTATCAGATGAAGAATTCGAGAAAGCGTTAAGACGCTCAGTTCACT CCACTGCGCTCCATAAAGAACACCGGTCAAGACCGCAGCTTTGTGGGGTGTGTGCTTGAAAGTTTAGGAC AAAAAATACAGTCAGGCCTATCTCAGACCACATACAAACACTTCGATGCCCCCCCACCCCCGCCCCCAGA GCTCGAACGCAGGACTCTGGCTTAGCTCGCCACCCTGCCACCCTGCGCGGCGGGGTCGGAAAGTGCTATC CCGGGCTTCTCGCGGCAGCGCTCCCCGCTCTAGCCCTGCCCCCCGCCGGGTCCGCCAAGCTAAAGAGCAA AAAGTCCGCCCGGGCCCGCCTCCTTCTAAAGCATCTCTGGAGACAGCCTGGTGGCAGGGGAAAGAGCACA GAGTCTCACGGGCAGAGGGTCTTTGATCCCCACCTACTGTCCAAACAGTTTCACCTGCGATTGATTAACA GTCTGTAACATACAGAGAAAGACAGGGCTGGAACCCTACCCGTCGGAAACGTGCCCAAACACGTGGAAGA AAATTCTCTACCTAATACACTTTCCAGGCTTCGGTTGTCCTGAATATAATCCCAGACAGTGGATCTTACC CAGGGAGGAGATGGAAAGGTGCGGGAACCGCCCTTGGACCGAGGCTATACAGCTGCCACCTCTAACGATA GCCATACGCAGGTCACTAGCCTGACCCCATATCCATCCACGGCTACACACGCTGTAAAGTAACTCATTGT AGGGTATACAGTGTGTGTGTGTGCGGGTGGGTGCTCTTGGGGACACATTTGGAAAGCAGGTCTGTTTGCA ATGTCAACGTTTTTCAGTGTCAAATTCCTGCAGCCTAACGGAGGCAAGGGGAGAGCCGAGTTTCAAAGAA GGGCTGCCCGGCTGCACCTTACTGTGGGCCAGCCTGATAGCGGAGGGGACTGGAGAGCTGCGCTGAAGTC GCCGGGAGCCGCTTTTTCTTTGTGGCCTCAGATTTCAACCCATCAGGGTCAGAGTTAGTTCTTTGTCTAG CGCCCCTTTGAGTTCTGCAGCGTCTAACCCCTAGACTAGGCTGATAAATCAACCCGTAGGCGTCTCTCGA TTTCTCTCCTACTTTTAAGTGTGGGGCTTCTTTTACTGAGCTCGAAACGTCCTGGTCAAAGCTGGTGGAA GGTGATGCGTCTGTGTTCAAACCTGTTGCATATCCTTGCTTAACGCAGGGACCTGAGAAAGTCTCCAATC GTGACTCTCACTGAAGATGCTGCGACAGAGGTCCTTACTCGCAGAATTAGGATCAGTGTACTCCTGTATA CTCTGCGCTTAGGACTTAGCGCCCTAACCCGGACCAGTACTTGGGGGAGGGAGTAGGAGGAAAAGGGTCA CAAGTCAGGGAAGTAGGCAGGGGCGGCGGGCGACTTACGGGCATCCTGGCCCTGACACCGTAGGACCGCG GCGATGAGCAGCGTCAGCAGCACCAGCGACTGGGGAGCCCCGAGGCGGATCATGGCTCACCGCGAGGCCT GGCAGAGCCTGGCCCGGGCGAAGCGCAGCGAGGCGGCAGAGCACGGAGCGGGTCCGGGTCTCTACCGCTC CCTCATGCAGGAGGCCCTAGGAGCAGGAGGAGGCAGGAGACCCGGCAGCCCAGCGGCGCTCTGCGTCTTC CCCCGGCAGAGGCTCCAGTTATATGCTCCCGGTCGCTCCAAAGGCTGGCAAACCGGCCCAAACCGCGGGC CGC >NP_001106987.2 collagen alpha-1(II) chain isoform 2 precursor [Mus musculus] MIRLGAPQSLVLLTLLIAAVLRCQGQDARKLGPKGQKGEPGDIRDIIGPRGPPGPQGPAGEQGPRGDRGD KGEKGAPGPRGRDGEPGTPGNPGPAGPPGPPGPPGLSAGNFAAQMAGGYDEKAGGAQMGVMQGPMGPMGP RGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPAGKPGDDGEAGKPGKSGERGLPGPQGARGFP GTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDG QPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGSRGEPGNPGSPGPAGASGNPGTDGIPGA KGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQAGEPGIAGFKGDQGPKGETGPAGPQGAPGPAGEE GKRGARGEPGGAGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLTGPKGANGDPGRPGEPGLPG ARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLAGAPGL RGLPGKDGETGAAGPPGPSGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKQGDQGIPGEAGAPGLVGPR GERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGAAGPDGPPGAQGPPGLQGMPGERGAAGIAGPKGDRG DVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPSGSTGARGAPGERGETGPPGPAGFAGP PGADGQPGAKGDQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPP GANGNPGPAGPPGPAGKDGPKGVRGDSGPPGRAGDPGLQGPAGAPGEKGEPGDDGPSGLDGPPGPQGLAG QRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGR DGAAGVKGDRGETGALGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIAGPQGPRGDK GESGEQGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGSNGIPGPIGPPG PRGRSGETGPVGPPGSPGPPGPPGPPGPGIDMSAFAGLGQREKGPDPMQYMRADEADSTLRQHDVEVDAT LKSLNNQIESIRSPDGSRKNPARTCQDLKLCHPEWKSGDYWIDPNQGCTLDAMKVFCNMETGETCVYPNP ATVPRKNWWSSKSKEKKHIWFGETMNGGFHFSYGDGNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIA YLDEAAGNLKKALLIQGSNDVEMRAEGNSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPM DIGGAEQEFGVDIGPVCFL Protective antigen hsp65 Mycobacterium leprae 34333423 CDD:295468 1769 ? heat shock protein 65 4.14 19773.694 271 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; cl02777 >AAQ64514.1 heat shock protein 65, partial [Mycobacterium leprae] EDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVKEGLRNVAAGANPLGLKRGIEKAVDKVTETLL KDAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGY FVTDAERQEAVLEEPYILLVSSKVSTVKDLLPLXXXXXXXGKSLLIIAEDVEGEALSTLVV Protective antigen Ifng (Interferon gamma) Mouse 15978 33468859 NM_008337 NP_032363.1 MGI:107656; UniProt:P01580 10090 ? >gi|145966741|ref|NM_008337.3| Mus musculus interferon gamma (Ifng), mRNA ATAGCTGCCATCGGCTGACCTAGAGAAGACACATCAGCTGATCCTTTGGACCCTCTGACTTGAGACAGAA GTTCTGGGCTTCTCCTCCTGCGGCCTAGCTCTGAGACAATGAACGCTACACACTGCATCTTGGCTTTGCA GCTCTTCCTCATGGCTGTTTCTGGCTGTTACTGCCACGGCACAGTCATTGAAAGCCTAGAAAGTCTGAAT AACTATTTTAACTCAAGTGGCATAGATGTGGAAGAAAAGAGTCTCTTCTTGGATATCTGGAGGAACTGGC AAAAGGATGGTGACATGAAAATCCTGCAGAGCCAGATTATCTCTTTCTACCTCAGACTCTTTGAAGTCTT GAAAGACAATCAGGCCATCAGCAACAACATAAGCGTCATTGAATCACACCTGATTACTACCTTCTTCAGC AACAGCAAGGCGAAAAAGGATGCATTCATGAGTATTGCCAAGTTTGAGGTCAACAACCCACAGGTCCAGC GCCAAGCATTCAATGAGCTCATCCGAGTGGTCCACCAGCTGTTGCCGGAATCCAGCCTCAGGAAGCGGAA AAGGAGTCGCTGCTGATTCGGGGTGGGGAAGAGATTGTCCCAATAAGAATAATTCTGCCAGCACTATTTG AATTTTTAAATCTAAACCTATTTATTAATATTTAAAACTATTTATATGGAGAATCTATTTTAGATGCATC AACCAAAGAAGTATTTATAGTAACAACTTATATGTGATAAGAGTGAATTCCTATTAATATATGTGTTATT TATAATTTCTGTCTCCTCAACTATTTCTCTTTGACCAATTAATTATTCTTTCTGACTAATTAGCCAAGAC TGTGATTGCGGGGTTGTATCTGGGGGTGGGGGACAGCCAAGCGGCTGACTGAACTCAGATTGTAGCTTGT ACCTTTACTTCACTGACCAATAAGAAACATTCAGAGCTGCAGTGACCCCGGGAGGTGCTGCTGATGGGAG GAGATGTCTACACTCCGGGCCAGCGCTTTAACAGCAGGCCAGACAGCACTCGAATGTGTCAGGTAGTAAC AGGCTGTCCCTGAAAGAAAGCAGTGTCTCAAGAGACTTGACACCTGGTGCTTCCCTATACAGCTGAAAAC TGTGACTACACCCGAATGACAAATAACTCGCTCATTTATAGTTTATCACTGTCTAATTGCATATGAATAA AGTATACCTTTGCAACC >gi|33468859|ref|NP_032363.1| interferon gamma [Mus musculus] MNATHCILALQLFLMAVSGCYCHGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQI ISFYLRLFEVLKDNQAISNNISVIESHLITTFFSNSKAKKDAFMSIAKFEVNNPQVQRQAFNELIRVVHQ LLPESSLRKRKRSRC IFN-gamma plays a critical role in Th1 type immune response. It is important for protection against infections by various viruses and intracellular bacteria. Vaximmutor The experimental data demonstrated that three time vaccinations with BCG in BALB/c mice induced strong TB Ag-specific IFN-gamma immune responses in splenocytes [Ref2101:Wang et al., 2009]. IgG (partial) Rattus norvegicus 204718 CDD:209398 10116 ? immunoglobulin gamma-1 chain 106 Immunoglobulin domain; cl11960 >gi|204718|gb|AAA41373.1| immunoglobulin gamma-1 chain, partial [Rattus norvegicus] RTQVPHVYTMSPTKEEMTQNEVSITCMVKGFYPPDIYVEWQMNGQPQENYKNTPPTMDTDGSYFLYSKLN VKKEKWQQGNTFTCSVLHEGLHNHHTEKSLSHSPGK Vaximmutor Il10 from Rattus norvegicus Rattus norvegicus 25325 148747382 AABR06074649 NP_036986 10116 13 52824593 52828559 + interleukin 10 8.68 19532.21 178 Also known as IL10X >gi|389675116:52824593-52828559 Rattus norvegicus strain BN/SsNHsdMCW chromosome 13, Rnor_5.0 TCGGTATAAAAGGGGGACACCGGGCAGGAGATCTACACATTAGGGACTTGCTCTTATACTACCATAGCCA CAACGCAGCCTTGCAGAAAACAGAGCTTCAGCATGCCTGGCTCAGCACTGCTATGTTGCCTGCTCTTACT GGCTGGAGTGAAGACCAGCAAAGGCCATTCCATCCGGGGTGACAATAACTGCACCCACTTCCCAGTCAGC CAGACCCACATGCTCCGAGAGCTGAGGGCTGCCTTCAGTCAAGTGAAGACTTTCTTTGTAAGTATAATGC CCACCTAGCCTTTCTTCCTAGGATCAACTGAAATATGCATTCTGATGGAACTGTAGCTCTCCTCCTCCTC CTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCCTCCTGCTACTCCTCC TCTATCTCCAGCATCTATTACCCTTAAACTTGAATCCAGAGAGTCCTAGGCCAAGCCATGGGTTATGAGT TAAACTAAATCCAGGCATAGCTGAAAACTAGGTTAACTAGCTAGCTAGCTAGCTAGCTAGCTAGGTTAAC TCCTAGCTAGCTAGGAGGTGAATGCATTGACTCTCCCATGCTCAAGAACTTTCTGTTAAGTTTCCGATGA GACCCCATGTTTTGCTGGCTAGGACAAAGCCTGGGGTAGAAGATACATGCTGTCTCTGCTTAGTCTCAAG ATCTGGAGGACCAAAGTCTGGGGGTTTGGGGGAACACCAGAGCTCAGGAAACTGCTGTAGGAGGTCCAGA GAAGGCAGAGAACCATGCAAAGCAGAGGCTTGCCGTAAGGGACTCCAGACAGGAAGGCTTGACACAGGTG CCCTAGAAACCTCAACTGACTCATCTGAAAGAAGACCAGGCCTGGGTCAAACTTCTCCCAATCTGTTAAA TTCAGTCAGAAGTTTTTAAAAACAACTTGATCCAAAGAGGAAGGACTTTGATTTAACTCCGGGCTCTAGC ACCATCTAATCCTGTTTTTAAAACTCACCTTTCCAAAGTCACCAGGGCTACCTTGATTACAAATTCAAAA CTCTACAAATGGAAAAGGTATTCAAATGGCACGCGTGATGGGTATTCCCCCAGCCCTTGTATTCATGGTC CTATTGTCCCTCCAGCAAAAGAAGGACCAGCTGGACAACATACTGCTGACAGATTCCTTACTGCAGGACT TTAAGGTAAGAATCCACTGGGTGCTGGGGAGCAATTAAGTGATTAGGGAGGGGAGGTGCTGCTTGTGACA GAGAGAGCTGGGTCTGGTGCCGTGGCTTTCAAAAAGAGAAGTGAGAAGACCTTAACTCAGCATATTGCCA GCAGTCGAGGGTTATGAAGAGCTCATTCTGTGGTAAAGAGAGAAAATGTAACTGGGGGGGGGGGGTCCCC TAGGGACAAGACTGTCCATCAACATTAGTGGCAACAGTCCATCCTTCCAATAAGCCACACCCAACCTTTG ATCCCTGCCTTTAGGGTTACTTGGGTTGCCAAGCCTTGTCAGAAATGATCAAGTTTTACCTGGTAGAAGT GATGCCCCAGGCAGAGAACCATGGCCCAGAAATCAAGGAGCATTTGAATTCCCTGGGAGAGAAGCTGAAG ACCCTCTGGATACAGCTGCGACGCTGTGTGAGTAGCAGACCAGTTCTTTCCCCTGTAGCCACCCAACAAA CACTGTCTCCTACAATCCAGCCAGGCCATGCGCATCCAGACACACACAGACTAGACAGAGGACTAGGTAA ATCTAGAGGGACACCCGGAGTCAGATCTCTTGCTTGTCTGTCTCTGGGCGAGAGTGGGGGTGGCTTTGAG GCGATCACACGTGAAGATTTGCGTATAGCCTTCCTGTTATTTGTGAGTCATTGTGGGTCATTAGCTACTC CCCTCTCTTCAAGGGAAGGCTAGGGCTTCAGTCATAGTTCCCTCGTGTTGGGGCTGCCAGCCAAGGCTCC CCAAGCAGAGGAAAACATTGGTCTCTGTATCTCCTCTTTTGGAAAGCAAAGTCAGTGCCACACACCTGGG CTGATAGAAATCTCCCCGGTATTTCAGAAGGGCCAGAAGACTACTGTCTCTAAGCCAGTATCTATGAATA GCATATCCAGGACATCTATGTCTCTGACTGAAGTGATTCCTTCGCTGCTGTTGTTTCTTCTTTCTTCTCT CACCGATACTGGAAAATCAGTTGGAGTCTACCTGTGCCCAACGATGGTTCTGGCCCAACAATTTGGCGCC AGTAACTGAGGCTTTTTCCGATCCACTCTCAGACACCTAGAAATAGCTCATGGTGGTTGAGATTGGAGCT AGACAAGGAGAGACATTAAAAACATAACATGTTTTGGGGCTGGCTCGGAGGAACAAAACCCAAGACCTAC CTAAGTTCACACCCACGCTCAGCAAACCATGATTTCAAAGACATACATTGTATCTTCTTTAGGCTGTTTT CCTCGGCACAGAAAGATAAAGGGCCAATCATGGCTCAGTTCTCCCTGGGGGCTAGGAAGTAGATATCGAA GATAAGCAAGGGTAGCTCCTTCCTCATTACAAGAAGATAGTTTCCTCCCAAGAGCCATGGATACAGGGTT CGAGCAAGAATTATCAACACTCTTTTTTTTTTTTTCTTCTACAGCATCGATTTCTCCCCTGTGAGAATAA AAGCAAGGCAGTGGAGCAGGTGAAGAATGATTTTAATAAGGTAAGCCTGGGCCATGGCAAAGAGAACGCG TGGAACGTGACCTCCGTCCGTCCACTCGCAAGGGCAGAAAGAGGGCCCGACCTATTCCGACCGAACCTGG AGTGTGGGAACCAGCAAATGGTGTGACCTCCTCTGCCAGTTAGAAAGCCACCACCTCAGTCACATTTGTT TTCTGCAAAGCGTCTCTGGCAGTTTCTAAATGACTGCTCCACTTTTGCAGGCTTTTGGCTTAGACTGACC AGACAGCCTATAAGCGCAGAGCGCTAGGTGCTGGGGAGAGCGCCGTAGGAAACAGAAAGTACAGAAAGTA CCTTGTTGGGAAACAGGCAGAACCCACAAGTACAGAAAGCAGACATGCATGAGTGCACGCAGGTACATCT TGGGGCTCAGCCTGGATGCTCCTCGGAACCAGAAGGAGCAGGAAGCAGAATTCTTAGGGGTCCCAGGGCA CTCTCCACCTGGCAAACAAAATGAGGTTTCATACTTCCTTCTGCCTGTGAACCTATTCAACCCTAGTTCC CAGAAGCCATGTGGCCCACATCTTCTTTGTGGGCTAGGCAGAGCTCCAACATCAGTGGGCATGGATTCCA TGACAGCAGGCCAGAGCAGCGGGGTGAAGACTGCCTACACACGCAAAACATTAAAAAAAAAATGTTTTTC CTTGTTATCTCTATCACTGTCCTGCTTTGAAATTGCTTCCTCTAGCATCTTTGCATAACATTCTGCATAC GCATTATGTGGGCACTGGCCTCTGGGGGGGGGGGGGGGAGTTGAAAAGGCTCTACTCTGAAGACAGTGCT TTGAGAACCGAATGCTTCCCTTTCCCTACTGACCCCTGGCAGTGCTTAAAGTCGGAGAAGGTGCAAGGGA AGACACAGCCCCTTCCCAAAGCAGATGAACAAATCTGCTTTGGGTCCTTCAGCTCCCAACACAAGAAAGC TGAGATCTTTCTACACTCAGTGGCCTTCCTAGTGCAGGGAGCCCCTCAGCCCTCCAATGGGTCCTAACCA GATTCTTCTCTCCCCACACAGCTCCAAGACAAAGGTGTCTACAAGGCCATGAATGAGTTTGACATCTTCA TCAACTGCATAGAAGCCTACGTGACACTCAAAATGAAAAATTGAACCACCCGGCATCTACTGGACTGCAG GACATAAATAGAGCTTCTAAATCTGATCCAGAGATCTTAGCTAACGGGAGCAACTCCTTGGAAAACCTCG TTTGTACCTCTCTCCAAAATATTTATTACCTCTGATACCTCAGTTCC >gi|148747382|ref|NP_036986.2| interleukin-10 precursor [Rattus norvegicus] MPGSALLCCLLLLAGVKTSKGHSIRGDNNCTHFPVSQTHMLRELRAAFSQVKTFFQKKDQLDNILLTDSL LQDFKGYLGCQALSEMIKFYLVEVMPQAENHGPEIKEHLNSLGEKLKTLWIQLRRCHRFLPCENKSKAVE QVKNDFNKLQDKGVYKAMNEFDIFINCIEAYVTLKMKN Other TGF-B from Rattus norvegicus Rattus norvegicus 59086 11024652 AABR06003977 NP_067589 10116 1 83742150 83758471 + transforming growth factor, beta 1 8.63 42045.82 390 Also known as Tgfb >gi|389675128:83742150-83758471 Rattus norvegicus strain BN/SsNHsdMCW chromosome 1, Rnor_5.0 TCAACCTCAAATTATTCAGGACTATCACCTACCTTTCCTTGGGAGACCCCACCCCACCCCACAAGCCCTG CAGGGGCGGGGCCTCCGCATCCCACCTTTGCCCGGGGTTCGCGCTCTCCGAAGTTCCGTGGGGCGCCGCC TCCCCCATGCCGCCCTCGGGGCTGCGGCTGCTGCCGCTTCTGCTCCCACTCCCGTGGCTTCTAGTGCTGA CGCCCGGGAGGCCAGCCGCGGGACTCTCCACCTGCAAGACCATCGACATGGAGCTGGTGAAACGGAAGCG CATCGAAGCCATCCGTGGCCAGATCCTGTCCAAACTAAGGCTCGCCAGTCCCCCGAGCCAGGGGGAGGTA CCGCCGGGCCCGCTGCCCGAGGCGGTGCTCGCTTTGTACAACAGCACCCGCGACCGGGTGGCAGGCGAGA GCGCTGACCCGGAGCCCGAGCCCGAGGCGGACTACTACGCCAAAGAAGTCACCCGCGTGCTAATGGTGGA CCGCAACAACGGTGAGCTCTGAGGGGCTGGGGAGCCAGGAGGGAGCCCCCAGGGGGCGCCGGAGTGCAGG GGTCACCGGGAGGAAATTACCCGCAGAGGAAACTGGCTGGAGGAAGGGGACCCCTGGGGGCGCTGGGATG ACTGTTTGGGTGTCCCAAAGAGGATGGCGCTTACCCCTACCCCAGGTGTCTGGTCTTAGAGAGAAAGACA GCCTGCAAAAGTGAACCTCCCCTAGAAAGGCATGATCCTGGGGAGAGTCCACTCTAGAAGAGGAGCATTT GTCAGGTTTTGTTTTAAGTTCCCCTTATGGTGCCTGAAAATGCAAGGCTCGTTGGGTCCTTTTCCAGAAA GGTAAAGCCCGGCTCAGGAAAAATGGAAGGCGCCCAGCATTTGGGAAACAAGAGACAGTGTGGAAAGCCG ACACTAGACCGGGTCGTGAGATGGAGAGAAGAGATTCAAGGGAAAAAAAAAACCTAGGGGATGGGTACCC TAGAAATGCCAAATAAAATCTCTACTGGGCTTACTACCAGAAGGCGACAGGCGCGTGCTGGAGGGTGTGA TCTGTGGAGTCATTGTGGGGTTCCAAGTGATAGAGGAAAGCGAAGTTGTTAGGAGAAGGAGGCTAGAGAG AGAGGAGCGGAGAGGGTGCGGAAAATGAGCCCGGAGGTGTCACGAGTGTTTTGCTTGGGGGCGTAAAAAA GCTTGCGAGCGGGCAGGCGGAGCCCAGTGGAGGAAGCGAGCGAGTCCTCAAGAAATTTAGAATACTGGGT CATTGGGAAGGAATTATAAAAGAGGGGAGACTGGCGTAGGAAGGTGGCCCCGCGAGGCGGGCAGGCAGAA CAGGGATACTATGCCATCCAGGCGAGAGTGGCGAGCGCCCCTCGCCTGGGCGTGGAAGGGAGTGGCTGAA CCTCGGGCCCTAGGGGAGCTGCTAGAGGTAGGAGAGAGGCAGTCTTCAAAACCCAAATGAAAAAAACGAG TCGGTAAGGGTGAGGAATCTCCACGTGGGTGCCACGCGCGTGGGGAGGAGCTTGCGCTTCTTGAGGGGGT TAGAGGACCCCACGGAGCTGAACGCTGGCAGGCTGTACCCCCAAAGTCCCAGTTCCTTCTACGGGAGGCT GGGGAAAACCCAGCGTCCGGTCGCCTCGCCCTCCTCCCTTCCCTTTCCTTTCCGTGCCCAGGAGGAGGGG GGAGACTGAGAACGCGCGCGCGGAGCCTGGGGCGAGACGAGGCAGGTCCGGATCCCGCCCTCCCTAGGCT GTTAGTCTCCCGCCCTCCTCACCCCAGCAGTGGGCGGGGACACTCACGGCCTCGCCCTTTAGTCACCCAC GCGGGACCTAGGAGTCCAGTGTGACCGGGAACTGTGGGTGTCAGAAGCTTCTCCAGGTTTCACCGTCCTA ACCCCCAGAGGTGGACTTAAGAATTCCTTGCACATCGCTGAACCCAATTGTGGCTCAGGCCTAATGACAC CCCTCCCTAGTCACCATTTAATGTGACCTCTTCGTTAAAGTCTTTTCCTCTCCCCTAAGACTGTATTTCT TCTCTTACGCATATATCTCTTCCGGCATGTGCCTCCCCGTTTCCGTCTCCTCTCCCACGTATCTATTCAT CTCTATGTCACCCCACTTCCCTCTGCGACACCCACAATCCTTCCTGCCCTCTTATCTCTCCCCTATCTGC TACCCCCAACTGAGATCCCACCCCCTCCATTGTGGTTTGCTGAGTAACAACTGGTCCAAGAATAGGGCCC CTCTGTCCTTCATCGATGTCTGGGTCACCATCTCATCCCCACTACAGGAAGTCAAAAGCTCCAGTTGATG GAGGATTTCAGGACTTTGCCCCTTCGTCCACCGACGCAGACATCCTTTAGCCAAGGAAGCCCTTTAGTGA ATGGGGCTCCCAAACATGCAGTTATTCTTGCCTAGAAATCAACCTCGCTACTAACCCGGCCAGGAAGTGG GCTAAAGAGGGAAGTAGCCGATGATAGGCAGATGATAATTACCCTGCACTGGCCAGGAAGTAACAGAGTT TCACGATTAAGACCACAGTCTGGTTGTCTCTACACCTGATTCCCCACCCCCCCAACTCCCCTCTCCCACT CAGTTCTCTCCCTTCATCACCTCTGATGGCTTCCTGACTTGATGTGCAGGGCTGGATTGGTACCCAGCGG TGAGGGAAGGGGCTGTGTGAGGGGGGGACTGGAAAGAGGGAAATCTTCCGTTGGGATGAATAAATAAATA AGTAAATAAATAAGTGGGGGGGGGGACAAACCACCATCTGCCAAGCAGAGCCGTCCATGACTGTAGTCCC AGTACGAGGGAGATAGAGGCGAAAGGATTGCTTCGAGCCTAAGCTATGAGATCCTGTCACCAGAAACAAA AGAAAATAAACAAACAAAAAATTAGCCCCTAGCATAAGATGGCTTGAATCTTACCACATTGTGAAGTCTT GATGTCTTTATCTTTGTAGTGTTTAAAACAATTTCGTTACCATTCACTGTATTCCCCTCACCCTTATTCA CACATGCATGCACGCATGCACGCAGGCAGGCAGGCAGGCTAACTCCCAGTGAACAGCTTCCTGACTCGGG CTCCTGAGTGCTGCTGGCTGCAGACTCGCACCGGCTAAAATACACATTATCGACGTGTGTGTCACATGTT TAGCTTTTGCCCCATGTCTTATCAGCTCCCTGGAATTGGATGGTATCTTGCAGTTAAAGAGAAGAATTTG CTCACCATTGGGTACATAGTGCTTCAGTTGAGGCCACCTCAGTTGGGAGTCAGAACTTAATGGTACCTGT TTCTTCCAAGGTCAGAAGGAGATTGGCCCAATGGGAGAGCATTTCCCTAGAATCCACCTTTGAGGTGTTC GCTCCAGCACAGCTGTTCGTTCCAGCCTAGAACCCGCTGTGGAAGTCACTCAGTGCCACTTTCTGGTCCC CACAATTATGCTATGCCATTCACTCTACAACTGCTGTGTGGTTTTGTTTGAGGTGTGGTTTTGTTTGAGG CGTGGTCTCGCAAAGCCCAGGTGAGGTCAGCCAGTTAAGAGCATTAGAGAGGGGCTCAGCAGTTCAGAGA ACCAGCTGTTCTTCCAGAGGTCAGCCGGGGCCCACATGGCTGCTCACAGCCCTCTGTGGCTCCAGTTCTA GAGGATCTGACGCCCTCTTCTGGCCTCCACAGGCGCCAGGCATACACTCAGTACACAGACGCACAGACAC AGCCGAGAACACCCATAGACTTAAAGTTAGAAGAGTGGACATGTCAAAGTGGAGCGCCAACCTGAGTTAG AGCCCATGGGCTCAGAAGCAGGGCACCTCTTTTTCTCCCATCCTCGCCACAGACCTGATGTCTTTCTCCT TCTGCTCCTCCCCACCCAGCAATCTATGACAAAACCAAAGACATCACACACAGTATATATATGTTCTTCA ATACGTCAGACATTCGGGAAGCAGTGCCAGAACCCCCATTGCTGTCCCGTGCAGAGCTGCGCCTGCAGAG ATTCAAGTCAACTGTGGAGCAACACGTAGAACTCTACCAGGTGAGGCTTTGAGCCTGAGAGGTGGCTCAC AGGTCACAACTGCTGAGGTGTGGCCAGGTGGCTCTGTTTGACAACTACAGGGCACACAGCCAGTCCTTGA GGAGAGAATACAGAGTGTTGAAGCCTAAGGGTCTTCTTGTTTTCTTTTGGTTGGTTGTTTCGGTTTTTCA GGACAAGGTCTCTGTGTAGCCCTGGCTGCCCTAGAACTCACTCTGTAGATCAGGCTGGCCTCAAATTCAC AGAGATCCATCCACCTGCCTTTGCCTCTCCAGTGCTGGGACTGAAGGCAGGTGTGTGTCACCATAGCCCC CGAGAATCCTAAGGTTTTTAAAAAATGCTTAGATTTCGTCCCATTAGTTGAATTTGGGATGTTGAACTAA AAATGCAGAAAGAGCCATGGGATGGATATCTGGATTTGTATGCTTGCCTAGAATCCCCCAGTGAGGGGCT AGGGGCGTGGCTCAGTGGTAGACTGCCTAGCATGAGTAAAGCATGGGGGTGGGAGTGGGTGGGTGAGGAG AGGGGATAACAGTGAGGAAGGAAAGGAAGTTGGCAGACACTTGCAATCCCAGCACTTGGAGGATGGAGGC AGGAGACCAGGAGTCTGAGGCCAGCCTGAGCTACTTGAGACCCCGTCTGGAGGCTGAGGCAATAAGATCT CTTGAACCCAAGTATTCAAGTCCAACATGGAATAGTGAGATCTTGTCCCGGACAGAGAAATTAAGCATTT GAAATGCCCTTGTAGTCTCTTAAGTCAGCAATCACCATTCTGGACTTCAAAAGTAGCTTCTTTTTTTCTT TTTAAAGACAGGGGTTCTCTGGGTGTCTTGGAACTCAGCAATCCACTCACCTCTGCCTTCTGAGACTTGG GCCTTAAAGGCTTGGGCCACCACTGCCAAGCCAAAAATAAAAATTTTAAACCAGGAGGCAGAGGCAGGAG GGTCTCAGAGTTCAAGGCCAGCCTGGTCTCCATTGTTAGCTCCAGAACAGCCAGGGCAACACAGAGAGAC CCTGTCTCAAAAAACAACAATGACAAAAACAAAAACATTGGGAAGACTGTTTTGTGAGTGTACTCATAAT AATAATTGTAAGTAAGATAACAAACTAAAGATAGAGAGATAGATAGATAGATAGATAGATAGATAGATAG ATAGGAAAGAGAGTCACCACTCTCCCAAACTCAGGATAGTAAACCGGTTAAACTGTGCTCCACAGTATGA GCAATGAGCACTTGCGTTGAGGGCCCTCCCAGCTGCTCAGCAGCGTCCACCATGGAAGAGATTGAGGTCC CGCAAGGCTGTTGAGTGCCCATAGCTTGCACAGAATCTCATGCCCAAGGGGGAGCCTCACGACTGACCAC AGCCTGGGGTTGTCGTTCCTGTCCCATGCTGTGTTCCAGTCTCTGTCCACCCCTCCACCCCCACTCCTGG CTACTTTTTGCTCTTGGGTGCTGTATGTGAGGGCGTGGCCTGCAGGATCCAGAGTCTGTACGTGTCAGAA GCCAGTGTCTGGGGGATGCCAGTTTGTGGGACAGGCAGCATGGGTTTGCAGCCAGATGATCTGGGGACAA GATGGCAGCCACCATACTCCTCTTTGCTTTCTTTGTTTCCATTCAGAAATATAGCAACAATTCCTGGCGT TACCTTGGTAACCGGCTGCTGACCCCCACTGATACGCCTGAGTGGCTGTCTTTTGACGTCACTGGAGTTG TCCGGCAGTGGCTGAACCAAGGAGGTGAGATTGCTTGTCTTGTACCATCCTCCAGTGGGCCCCCCCCCGT TTGTCCTGGCATCATTGTGCATAGCACTGCATTCCCCCCAACTGCACCCCTAACACACACACACACACAC ACACACAAACACACACCACACACACACTCACACACACACACACACACACACACACACACCACACACACAC ACACACACACACATACCTGGTACTGATGTCAAGAAGTAGTACTTCACAGTTCTTACCAATGGATCAATCT GTGGAGGGATGCTAGGGATAGACGGTGACCCAAACAGTCCCTATCCTTGCCTTCAGTAGACCGAGTGGTA CCTTGGACAGTTGAAGGATAGGTTGACTTTTAGCTGTGCTTTATGACTCATCGTAGAGAGGAACGTGGTT GAGCACTCAGGAGGTGCCTGACTGTCTGGATTCAAGGAGGGCTTCCTGTAGGAGAGGGCATCTGAGGTAA TGTCTCTGAGATGAATAAAAGCAAGCAGGAAAAGGAGAAATGAGAGTATCCTGTACCAAGGCTCTGCAGC CAGGGAGAGAGCCTGCTGTGTCCGTTTGTCCAGGAGTGAACAGTCTCCCTTGTCTCTTGTGGGTCCTTCC CTTGCAAGGCCCACACGATCTTTCCAGACACTGGTAAGGTCCTGTCAGAGCCCTAGCAGGCAGTAATGGC CTATAAGGATGTAGGCCAGAAAGGGAGACCTACAGAGAGGGCAAGGCTTAGATGAGGGAAACCAAAGTGT TGTGGAAACCCAGGCAAGGTTAGGACCCAGGAGGGCTTCTGGGATGAGAGAAGACTGACTCATGGGATGT GTAGTTTAGCCACATGGAGGATGAGTCCGAGTGGGCTGGCACCAAGAGGAATGTGGAAAGCCCACTGGAT GGAGGTCAAGAAGAATTTTGTGTGGTATACAGTAGGCGCTTAGTATCATTTATGTGTCCACTCAAGGAAC ATCTCCCTTGAACCAGTAAGATGGCTCAGCAGATAAAGGTGCCCACTGCTGAGATTAATGGCTTAGGTTC AAGCCCCAGGAACACCCAGGAAGTTGGAGGGAACCAACTTCTACAAATTGACCCCTGACCTCCCTGCATA CCCTGGCACATGTGCACCCCCCTGAATAATGAGAAGAGGCCAGCTTAGGTTTGCACCGTGCCTTTGCCTC TGGCTCCCTGTGTGGCCCTGGCTAAGTCGCTTCCTCCTGGAGTGAAGGACTCTGAAGATCAGTGGAGTTT AGATCAGTGAGTGACTGGCGTCTGTGTTCGCTCTGAATGTCCTTCGACACCAACACTGCTCCTGGCCCTT GGCACCTAGATCATGATGATGTTTATCTTTGTGACCAAGGACCAGGCTTTACAGAGCAAGAAGATAGCAA GAACCCAGGGCAACATGCCTGATGGTACGAAAGCCTGCTAAACTCTGCGCTTGGGAGGCGAAGGCAAGAG GATCATGAGTTCAAGGTCTTAGCTCCATAGTGAGTTCGAGAATTTGAGGCCAGCTTGGGCTACGTGAGAC CCTGTCTCCAAAGAAAAAGAGGGCCATGGAGAGGGGTCATGGGCGCAAGAGCTTCCATTTTGCAAGCACA AGGACCTGAATTCTCATCCCTGGCACTCATGTAAAAGTCCGACATTGGCGTAGTGTGTGCCTGTAACCCC AGCCTTGTTGGGGGTTCGGTGTATGTATGGAGACAGGCCAACTCATGACTCTGTGATCTGCCAATCTGGC CAAAGGGGTGGGCTCAAGTCCAGAGATCTGTCTGAGGCAATGAGGGAGAAAGGATTAGAGGAAGATGCTT GTCACCCAGGTATAAGCCTACCTGGTATAAAATGTACATTATACATGCATACATATACATATATACACAT ACATATCTACAGTTCCAAAAAATATAAAATGAAAGGAAATAAGGCAGGCACAGGATCCCTCCTCTGTTCA TGTTGTTCTACTGAGAATAATCAAAGAAGTAAATACTCATGCAGAAATGTCAGAGCCCCTGCCCGCTATG GAGGAAAGGAATGGATGCCACATTTGGAGAGGGAAGTGTCTCCTCAGAGCCTTTCCCAAGGGGTTGACGT TTGAGCTGAGCCCTGAATAAAGGGGAGAAGGAACCAGCAACTTAAAGAGCGAAAAGTGTGGGGTGACTAG CAAGGAGGCCCCAGGGCTGGCAGCTTCCTGCCCCCTCTCCCTTCCCCCCATCAAGGCCTCACCAGTCACC TCAGACTCCTTTCCTCTCCTGCAGACGGAATACAGGGCTTTCGCTTCAGTGCTCACTGCTCTTGTGACAG CAAAGATAATGTACTCCACGTGGAAATCAATGGTGAGTTAACTTCCCAGCTCCTGCCGGACACAGACCCT GCATGTGCGTGCGTGCGTGCGTGCGTGCGTGCGTGCGTGTGTGTGTGTGTGTGTGAGAGAAATCTCACTC GCCCCTTGCTCACCCATCCATCCCTCCACAACATTCAAACCCAAACAGGGATCAGTCCCAAACGTCGAGG TGACCTGGGCACCATCCATGACATGAACCGACCCTTCCTGCTCCTCATGGCCACCCCCCTGGAAAGGGCT CAACACCTGCACAGCTCCAGGCACCGGAGAGCCCTGGATACCAACTACTGCTTCAGGTAAACTCTGTCTC TCTCGGAGGCTGCACAGGCTGGGGGCTTGACTGCAGCCTGTGGACTGGTGTGCCACCATTCATGCCTGGA GGGCTTGGGGACAAGTTCTTGGTTCTGTGGGCAGCTGAGAGTCTAGAATGTGGGGTGTTTTCTGGCTGGA GTGTTCAGGTTAGCACAAGAGTTAGAAGTCGGTTGGAAGGTTATCTTGTTGGGTTTTAAAATTCTTGCTA GGCTTCCACCACTTTGCAATGCTAATGAAAGAATTTACTGTGAGCAATTGAGAGTGCTGACCCTAGAAAG CGGGAGAGTTGAGATCCAAGCATTTGGGTTCAGAATCAGAAGGCGGTCTGCACTGGGTTCCCACACTCGA GGCAGATGGTGGTCTCCAATGCTGGTAGTTGGGAACGACAATTATTGGGGCTCAGAATGGCAGGGTCTGG CATGGAGATGTTAGCGTTCAGAGTGGAGGTGGAGAAAGCCAGAATGTGAGTCCCCTGAGGGTCAGGGCTT CATCTTGCAGTGGTGCACCCTGAGGAAGCTGGGAGGCGGAACTTCCTGAGATGTAGGCTTACAAGTGTGG AGTGTTGGAAGACAGCACTGAAGCAGGGAACTCTGAGGAGTCGGAGAGTGGGCATCCTAGAGTGTCCAGA ATGGCCATCCCAAGGGCAAATGCTTTTTGGTCATTGTTTTTAAATTATATCTGTGTGTGCGTGTGTGTGT GCGTGCTTGCGTGTAGGGGCACCCATGCCATGACACTTGTGTGAAGGTCAGAGGACAACTGTTGGGAGTC CGTTCTCCTTCCACCGCGAGTGTCCCAGAGATAAGACTCAGGTTATCAGGTTTGGCAGTGAGCACCTTGA CCCACTTTGTTTTGTTCAAGACAGGGCTTTGCTGTGTGACTGAGGCTACCCTCAGATTCACTCCTTTAGC CCAGGCTAGCTTGAATTCTCTGTCCTGGGATTACAGGTGTTACCCAACCACCCCATTTCAGACAGAATGG CAGACTCATACTAAGCCTCGGTAATGCGGATTGCGAGAAAGAAGTTGAAACACTAGATCCTAGGAGGTGT GAAATTCAGGAGAGTTGAGATGAGAGCAGTGAGCTACCTGTCCCTTCCCTGCTTCAGACTTTATAGAGTG CTGTGTTGTATGTCGGTCCTTGGCTGGAGCTGCTCCTCCCCCTCCCCCACCTCCACCTCCTCCTCCTCCT CCTCCTTCACCGTCCCTTTTTTTTTTTTTTTTTTTGGTTCTTTTTTTCGGAGCTGGGGACCGAATCCAGG GCCTTGTGCTTCATAGGCAAGCGCTCTACCACTGAGCTAAATCCCCAACCCCCCCAACGCCTTCACCGTC CTTTTGCTGTTAGCCTTCACATAGGAACAGATGGAGGGGCTTCACACTGCAGGTTACTAAGAGATGAGAA AACTATGCAAGCTCTGTTCCCCGCATACTGGGAAACGAACTTAGGGAATCAGGAAAATCTCTTTGTCTGT CTGTCTGTCTGTCTGTCTGTCTGCCTGCCTGCCTGCCTGCCTGCCTGCCTCTCTCTCTACATTTGTTTTG TTTATGCCTGATGTATGTGTGGGCTCTGGGAATCCAAACCCAGGTCTTCATGCTTGCATAGCAAGCACTT GACTCACTGAGCCACGTCCTCTGCTGTGACAAGTCCCCAGTTGCTTGGAAGAACATAGTGCCAACGAAGA AGGCCTGTCAGATACATCAACCGTGATCTGATGGGGATGGTAGCTCCAACTCCCATGTTTCCCTGCAACA GAGGGACAGACTAGCAACATTAACCAGCACCACAGGGATGCACCCAGCAAAGTGCAGATGGTGGGAAACC TAGTCGTTTCTTTAACACATACAGTACAAAGAAGGGAGGGCAGGATATATAACCCACAGGACTAGAAGAG AGGGAGAGAAGGGCCAAGAGGTGGGAAGAGGAGGAAAGAAAAGGAAAGGGAAAAAGACTTTTATGGGATA TGGTGGGAAATATGAACCTTGAGTAGTATTTGATTTTAGTGAGTTACTGTTAAATTCTTGACCAGGGTTG GGGATGCTGTGAAGAGATGGCTCAGTGGTTAAGAGCACTGGCTGCTCTTCAAGAGAACCTGGGTTCAATT CCCAGCCCCCACATGGAGGATCACACCTGTGTGTAACTCTTGTTCCAGAAGATCTGATGCCCTCACACAG GCATAGATGCAGGCAGAACAGCAATGTACAGAAAAAAATTCTTGCCTAGGATTTTGTTGTTGCTGCTGCC TTTGTGATACTGAGGAGGGAACCCAGTACCTTGTACGTGGTAGAAAAGCAGTTGACCACTGAGCCACGCC CCCAGCCCCTCACTGGGGGATTCTAGGCAGGGGCTCTACCACTGAGCCACGCCCCCGGGCTCTACCACTG AACATATTGATCTATACTTTTGGTTCATGTTTAAATTGTAAAATATTCTTCACTTTCTAAGAGAAAGTGA ACCATTCTATAAAAGTTCATTAAACAAATGAGAAAAAAACTACAGTGGCGGACAGGAAGTGTAGGTAGGA TGAAATTAGCCACGAGTCAGCAACTGTTGCACTTAACAATTGTGGGGATGTGAATTAATTAAGAAACCAT AATTCAGAAGTCCAAAAATCTCTCTGGCCATGATGAGGAACAGGAACAGAAGGAGCTCAAAGTCATTGGT AGGTATGCAGTGTGTTTGTGGCAACCTGGACTACATTAGACCCTGCCTCAAGAAAAGGGTTGGGGCACCA GAGCTCAGCTGCTCTTTTATACAGGACGCAGCAGCTCTGGGGCGTTCTAGGCACCCACATGGCTGCTCAC AACAATCCATTAAGGCCAGTTCCAGGGAATCTCATTCCTTCTTCTGGCCTCTGCGGGCACTGCACGGATA TGGCGTGTGCACACATATGTGCAGAGACATACTCCTACACATAAAACTTTCTTTTAAATTGCCAGGTGCG GTGGCGCATGTCTCTAATCCCAGCATTCAGGAAGCAGAGAGAGGCAGATCTCTGTTTGAGTTTGAGGCTG GCAAGTTCACTCACATAGCAAATTCCAGGACATAACATGTCGAGATCTTGTCTCAAGAACTAGGAGGAAT AATAAAAATAAAATTGGGGGCTGGGGATTTAGCTCAGTGGTAGAGCGCTTACCTAGGAAGCGCAAGGCCC TGGGTTCGGTCCCCAGCTCCGAAAAAAAAAAAACCAAAAAAAAAACAAAAAAAAAATGTGGAGCAGGAGG GTACTTGACATTTTATAAAGTCTGTGTAAATATCCCCTTATCCCCAAAAGCTTTTAGTCCCTAGCACTTC TGAAAAGGGGTATTCAGTTTGTATTGTAACACTCTGCTTCTGTGTCCGTTCGCAACTTTCCACGGCAAAG CTGGTTTTATGCCAGCTTATCGGCTCAAAAACCACCTCCCCCAGGGCCGCAGAGAGGGCCCTTCACAGAT TAGGCACGGCTGGCTCTCAGTAGACTGGCAAGGGAGGCTTGAAAAAGCAGTGGCTGTGAAAATCCTAAGA CTGCTTCCCAGAAAGAAAGGCCGATATGTGCCAGGCTGTGGTGGTGCACAGCTTTAATCCCAGCACTCAG TAGGCAGAGGCAGGTGGATCTCTGTGAGGGCAAGTCCAGCCTGGCCTGTAGATTGAGTTTCAGGACAGCT GGGGTTACAGAGAAGAACCTTGTCTCCAAAAAAAGAAAGCAAGCGAGCCCTGGGGTGTGTCACCCTGGGG TGTGTCACCCTGGGGTATATCACGGTTACCCGGAAGGCTTGCTTGTTCAATATGGGCCCAGTGTCTCTGT CTCAGCAGAAACGAGTGGGTAGAGTCCACAGGAGCCCCAGTACCCTGAGCCTGGAGCTCTGTGCTCTGAA AAGGAGGTGTCACCCTGTCCCGGGAGCTGCTCACGAGAACCTCCCTTTCAGCCACCCTACCCTGTTGTGT CTCCTTCCAGAGTTTCTTTCTCTCTGTGGCATACCTTCAGATGCTTTGTATGTCATTGTTGAAAACAGGG TCTCCCCGTGTAGCCCTGCCTGGATTAAAATGTTCTGCATGGACCAGGCTGGCTTTGAACTTGCAGCGAC CCTCCCATTTCTGCTTCCTGACTGCTGGGGTTATAGGTGTGCACGTGTGCATAATCATGCCTGCCTGGCT CACATGTGTCAAATTTTATTTATTATTTTATTTTACATGCATGTTTTGCCCACATGGGTATATGTGCACT GTGCATACGTGATACCCAGAGGACAAAAGAGGACATTGGATCCCCTAGGTCTGGAGTTACAGATGGCCAT GAGCCTCCATGGGGGTGCTGGGAATTGAACCTGGGTCTTCTGCAAGAGCAGCCACTGCACTTGACCACTG AGCCATCTCCTAGTCCCTTGCCCACATTTTTAGAGTTATTTTTAAAGGTGTAATGAGGAGGAACCTGCAT TTTCCTTCCTTGAATTACTTCGTTCTGATTCTAAAAATAATCCCAGCCCCTGCTAAGAGTGTGGGAAATC CAGAAAGCCATCACACCAGGGAACATAAAGACCCACGGGCAGCATCTTTAGTGCGCAGTCTGCCGGCCTC TTTGTAATGGGATTTGATTTACTCACTACCTGCATCTTTAGATCCTGATTCTGATACATGCCGTGAACAC AGGTGCCCAAGTGTTCTTCTGGTCAGCCTGGGCTACAAGGTGAATTCTGGGGCAACTTAGGGTACATGGC GAGACCTCATCTTAACTTTCCTCCCTCTTGAGGGGATCGTGCAGGGTGAGGTGGCAATTGCTGGTAATTC CAGCACTTGGGAGGCGAAGGCAGGAATTATCAGGAGTTCATGGCCAGCCTGGGTTACCTAACAAAACCCA GTCTTGAAACAAAGGACTGACCAGTACTCAGGAAGCAGGGACAGGAGGGCCTCGGGCAGCCTGGTCTTTG TAGTGAATACTGGGACAGCCAGGACTCCACAGAGAGAGTCTCTCTTAAAAAAAAAAAATGTAATGTTTGT CAGTTAATTCATATAACCAGCATTTGCCAAGCATGTGTACATTAAGAGACACTGCCCCATGGTGAGATGA ATCAGATGATATTTAATAAAAACAAGCGGAAACATTCTGAGCAGGAAAATAAAGCTGGTGAAGGGGGCAG GTTAGAAGCCAGGCCAGGAAAAATGAATAATAGTGGAAGCCAAGTGTGGTGCACCCTTGTGATCCCAGCA CTTGAGAGGCAGAGGCAGGAGGGTCAGGAGTTTAGGGTTGGCCTTGGCTACAAAGGGTCTTGGAGTCCAG CCTTGGCTACATGAAAGCCTGTTTCAGAAAAGACAAAGAGGGGTTGGGGATTTAGCTCAGTGGTAGAGCC CTTGCCTAGGAAGCGCAAGGCCCTGGGTTCAGTCCCCAGCTCTGAGAAAAAAAAAAAAAAGAACCAGAAA AGACAAAGAACAAAAGACATCTTGGGGACTGATTAATTTTTCTATTCTGATGAAAATCATTTTATGGTGG AAAATTTAAATATAGACAGAAAAAGCAGAGGTAGTATAACCTTCCAGCTTCCAGAATTATCAGGATTTTG ATGACTCGCTTCAGACAGTTTGGGGCTGGAGACTTGGCCCAAGAGTTAAAAGCACTGGCTGTTCTTCCAG AGGACCTGGGTTCAGTTCCAAGCACCCGTATATGGTCGCTTAAAAGGACAACTATCAATAACTCCAGTTT CCGGGAACCTGATGCCCTCTTCTGGCCTTCTTGGGCATTGCACAAATATGGTGCACATAAAAATAAATCT TTAAAACAGAACAAGCCAGGTGGTGGTGGTGCACACCTTTAGTCCCAGCACTCTGGAGGCAGAGACAGGT GCGTTCCCAAGTTTGAGGCCAGCCTGGTCTACAGAGTGAGTTCTGGGTCAGCCAGGGCTACACAGAGAAA CTCTGTCTCAAGCAAGCAAACAAACAATACCGAAACAGCTGCATAGAAATTCACAGTCCTTGCAGTAAGT GTAGCATTGAATTCCCAGGATGGAATTGAACAGTTGTATGGAGGGACGCTTTGGATGGCAAGTGGGCAGG GCTGGTCAGAGGAGGGAGGCACTGTTCATTTATGTAACGGGGATACTGAATATCTGCCTCAAGCCAGGCA GCATTTTTAGGAGTTAAAGCTCCCTGGGTGGTAGATAGTATTTAAAGGCACCGTCTTACCCTGTAGCCGT AGCTACCCTGGAACCGTCAGGGATCCAGCCTACCCTGCCTCTTTGTTGGTAGTAAAGGTATGCACCGCCA TGCACGGATTCACTTTAATCTTGTTGTTATTTTGTGCAAGTGCCCACACATGCTGTGGTGCACACGAGCA GGGCAGAGGTCAGTCTCGTGGAGCCTCTTCTCCACACTCAACTCATCCGGTTTTCAAGTCAGGCTCCTTT ATCCGCTAGGCTGTCTTGTCAACCCTGAGTCAAACCTAAATGTAGTGAAGGAGGAAGCCAGAGTGGGCAT CTCTGGGAAGAACAAGTCAGGCAAACAAAAACAACCAGCGTGTGTAAATGCCCTGAGGTAGGCTTGACTG TGTCTGAGGACTAGAGAGGAAGCCTGTGTGGCTGATGTCAGGGGTGGGTGAGGGCAGAAGCTGAGGAAAG CCATATTCGGTGTACCTGTGACTCATGGTGATAATTTAGGCATTTGTAGTAAAGGGGAAGGAAGAGTATC ATAGCCGGCTATGGCCTCCAAAGGCTGCCCTCGGCCTTGTTTGTGCCACTCAGCTGCACAGGCCTTAGCC CCACATGCAGTAGAGGTTCAGTAAACACTTGTCGGACAGATAGGATGTGTCGGCACACGTGGGGCCGTGG ACATGGCATGATTTATTACGTCCCCCCCGTGAGTGCTCATGGGCCTTCTCAGTGCCTGTCGTGATGGATG GTTGTAGTGTTTCTGTTATCGCAGGGGTCCTGGGGAGCCTGGGCTGGAGGCTGAGGGCAGCCTAGGGTTG GAGGGGGCAGCAGGGTTGTCCCTGCTCCTGACCTTTGTTCCTCCCGCCTGCAGCTCCACAGAGAAGAACT GCTGTGTACGGCAGCTGTACATTGACTTTAGGAAGGACCTGGGTTGGAAGTGGATCCACGAGCCCAAGGG CTACCATGCCAACTTCTGTCTGGGGCCCTGCCCCTACATTTGGAGCCTGGACACACAGTACAGCAAGGTG GGTCTGGCCTGTGGGACAGGCTGGAGCAGAGGCTGGGTGGTTGGGAGAGAATGAGAGGCTAGAGCAGTGG GGGAGTCAAGGGAATAGGGTGACAGGGAAACAGAGGAGAGACAGAAATACAGAGAGGCAGAGTTGGAGAG ATGGGAAGAAACAGATTAGGTGAGAAAGACAGGAGAGCTAGTGATGTGGAGAGACACAGAAATGGAGGTG GGGAGGATTGGAGATGGGAACTAGAGTAAGTGACCAAGACAGACAGGGAGGGGAGATAAGATGAAGAGAG GGAGAGAGGAAGAGGCAGAGATGGGGGCAGATGAGAGAGAGGTGGAACATTAGGAAGAGACATAAATAGA AATAGACTAGGATAGGTATCGAGGCCGATGGAAGCTGGGGAGACTCAGAGATAAGAGACAGAAATGTAGA GATCCTGGTAGGGAGAGAGACCGGGGAGTCCCTGGACACTGGCAGTGACTCTGGCCCACCCGCAGGTCCT TGCCCTCTACAACCAACACAACCCGGGTGCTTCCGCATCACCGTGCTGCGTGCCGCAGGCTTTGGAGCCA CTGCCCATCGTCTACTACGTGGGTCGCAAGCCCAAGGTGGAGCAGTTGTCCAACATGATCGTGCGCTCCT GCAAGTGCAGCTGAGGCCCCGCCCCCGCCCCGCCCCGCCCCTCCCGGCAGGCCCGGCCCCGCCCCCGCCC CGCCCGCAGTGCCCGGGGCTGTATTTAAGGACACCTGCACCCCCCCCAAGCCCATCTGGGGGCCCATTAA AGGTGACAGAGG >gi|11024652|ref|NP_067589.1| transforming growth factor beta-1 precursor [Rattus norvegicus] MPPSGLRLLPLLLPLPWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPP GPLPEAVLALYNSTRDRVAGESADPEPEPEADYYAKEVTRVLMVDRNNAIYDKTKDITHSIYMFFNTSDI REAVPEPPLLSRAELRLQRFKSTVEQHVELYQKYSNNSWRYLGNRLLTPTDTPEWLSFDVTGVVRQWLNQ GDGIQGFRFSAHCSCDSKDNVLHVEINGISPKRRGDLGTIHDMNRPFLLLMATPLERAQHLHSSRHRRAL DTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGA SASPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS Other TNF-alpha Mus musculus 21926 7305585 AB039224 NP_038721 10090 17 35199389 35201995 - tumor necrosis factor 4.75 24010.47 235 Also known as DIF; Tnfa; TNFSF2; Tnfsf1a; TNFalpha; TNF-alpha; MGC151434 >gi|372099093:35199389-35201995 Mus musculus strain C57BL/6J chromosome 17, GRCm38 C57BL/6J CTTTATTTCTCTCAATGACCCGTAGGGCGATTACAGTCACGGCTCCCGTGGGGAGCAGAGGTTCAGTGAT GTAGCGACAGCCTGGTCACCAAATCAGCGTTATTAAGACAATTGGGTTAGATAAATATTTTGTTTTAAAC ATAAGCAAAAGAGGAGGCAACAAGGTAGAGAGGCCAGGTGGGGACAGCTCAGCTCCGTTTTCACAGAAAA CATGTCTGTCTGAAGACAGCTTCCCACACTGGGTCCTCCAGGACACCCCGGCCTTCCAAATAAATACATT CATAAGCAAATAAATAAATAATAAATAAATAATAAATAATAAGTGCAAATATAAATAGAGGGGGGCTGGC TCTGTGAGGAAGGCTGTGCATTGCACCTCAGGGAAGAATCTGGAAAGGTCTGAAGGTAGGAAGGCCTGAG ATCTTATCCAGCCTCATTCTGAGACAGAGGCAACCTGACCACTCTCCCTTTGCAGAACTCAGGAATGGAC ATTCGAGGCTCCAGTGAATTCGGAAAGCCCATTTGAGTCCTTGATGGTGGTGCATGAGAGGCCCACAGTC CAGGTCACTGTCCCAGCATCTTGTGTTTCTGAGTAGTTGTTGAAAGCTCTGAGCACAGAGTTGGACCCTG AGCCATAATCCCCTTTCTAAGTTAGAAGGATACAGACTGGGGGCTCTGAGGAGTAGACAATAAAGGGGTC AGAGTAAAGGGGTCAGAGTGGGGGCTGGGTAGAGAATGGATGAACACCCATTCCCTTCACAGAGCAATGA CTCCAAAGTAGACCTGCCCGGACTCCGCAAAGTCTAAGTACTTGGGCAGATTGACCTCAGCGCTGAGTTG GTCCCCCTTCTCCAGCTGGAAGACTCCTCCCAGGTATATGGGCTCATACCAGGGTTTGAGCTCAGCCCCC TCAGGGGTGTCCTTGGGGCAGGGGCTCTTGACGGCAGAGAGGAGGTTGACTTTCTCCTGGTATGAGATAG CAAATCGGCTGACGGTGTGGGTGAGGAGCACGTAGTCGGGGCAGCCTTGTCCCTTGAAGAGAACCTGGGA GTAGACAAGGTACAACCCATCGGCTGGCACCACTAGTTGGTTGTCTTTGAGATCCATGCCGTTGGCCAGG AGGGCGTTGGCGCGCTGGCTCAGCCACTCCAGCTGCTCCTCCACTTGGTGGTTTGCTGAGGGGGGGGGGG AGGATTGAGTCAGTGTCACCCTCTTAGTTCACACTCCACATCCTGAGCCTCAGCAGCTACCCACACTTCA CTTCCGGTTCCTGCACCCTCTGTCTTTCCACATCCCATTGGCTATGAGGTCCCGGGTGGCCCCCTGATGC CTTGCTTTTGAGTCACTGCTCTGACTCTCACGTGCTGTCTCTAAGAGCTCTGTCTTTTCTCAGCCTGGCT CGACACCCCTCAACCCGCCCCCCAAAATCATGCCCCTTCATTCTCAAGGCACATGTAAAGAAATCTTACC TACGACGTGGGCTACAGGCTTGTCACTCGAATTTTGAGAAGATGATCCTGGAGGGGAAGAGACAAAGGCA AGGATGAGCCTTTTAGGCTTCCCAGCAAGCATCTATGCACTTAGACCCCTTTCCTCCCAAACCAAAGCTT TAAGTTCTCCCCCCACCCCATCTCATCCCATGCCTAACTGCCCTTCCTCCATCTTAAATTAAGAGAGAGG TGTGGGAACACTTACTGAGTGTGAGGGTCTGGGCCATAGAACTGATGAGAGGGAGGCCATTTGGGAACTT CTGTGTAGGAAAAGGAGGTTAGTTAAGACAGACTCACCCCAAAGGAGAAGCCTCCCGGCTGATTGCCCCG CTTACAGTTCCTCTTTGCCCCACCCCACCCCCCAGCTTTGTGTTTTTCTTCTTCATTCATTCATCTGTCC AACCCACGGCTTCTTTCTGCGGTGCCCTCTGTGCTTGATCTCCCGTTATCTCCCCTTCATCTTCCTCCTT ATCTCTCATGCCTCTCTCATTTCTGTCTCTGAGTTTTATCTCTTGCTTATCCCCTCTTCCCCTGGCCACA TCTTTCCAGATCTCTCCACGTGTGAACACACTTGTTCGTTCATTCATCTCTCTGTGCATCCGACGAAGGA TGTTTAGTCAGCTGGACGCATGGGTCCGAGGTCCTGACTCTGTCCCCTCCACACTCTCCTCCACCTTGCC CTGCCCATTAGCCCACTTCTTTCCCTCACACTGTCCTTCTTGCCCTCCTAACCCGTTTTGCTTGTGAGCG AGAATAAGGGTTGCCCAGACACTCACCTCATCCCTTTGGGGACCGATCACCCCGAAGTTCAGTAGACAGA AGAGCGTGGTGGCCCCTGCCACAAGCAGGAATGAGAAGAGGCTGAGACATAGGCACCGCCTGGAGTTCTG GAAGCCCCCCATCTTTTGGGGGAGTGCCTCTTCTGCCAGTTCCACGTCGCGGATCATGCTTTCTGTGCTC ATGGTGTCTTTTCTGGAGGGAGATGTGGCGCCTTGGGCCAGTGAGTGAAAGGGACAGAACCTGCCTGGTT GGCTGCTTGCTTTTCTGGGAGCTATTTCCAAGATGTTCTGGAGTTTCTGTTCTCCCTCCTGGCTAGTCCC TTGCTGTCCTCGCTGAG >gi|7305585|ref|NP_038721.1| tumor necrosis factor [Mus musculus] MSTESMIRDVELAEEALPQKMGGFQNSRRCLCLSLFSFLLVAGATTLFCLLNFGVIGPQRDEKFPNGLPL ISSMAQTLTLRSSSQNSSDKPVAHVVANHQVEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQ VLFKGQGCPDYVLLTHTVSRFAISYQEKVNLLSAVKSPCPKDTPEGAELKPWYEPIYLGGVFQLEKGDQL SAEVNLPKYLDFAESGQVYFGVIAL Vaximmutor TNF-alpha from Rattus norvegicus Rattus norvegicus 24835 6981662 AABR06099883 NP_036807 10116 20 6936228 6938846 + tumor necrosis factor 4.9 24217.89 235 Also known as Tnfa; RATTNF; TNF-alpha >gi|389675109:6936228-6938846 Rattus norvegicus strain BN/SsNHsdMCW chromosome 20, Rnor_5.0 ACACCAAGGGACCAGCCAGGAGGGAGAACAGCAACTCCAGAACACCCTGGTACTAACTCCCAGAAAAGCA AGCAACCAGCCAGGCAGGTTCCGTCCCTCTCATACACTGGCCCGAGGCAACACATCTCCCTCCGGAAAGG ACACCATGAGCACGGAAAGCATGATCCGAGATGTGGAACTGGCAGAGGAGGCGCTCCCCAAAAAGATGGG GGGCCTCCAGAACTCCAGGCGGTGTCTGTGCCTCAGCCTCTTCTCATTCCTGCTCGTGGCGGGGGCCACC ACGCTCTTCTGTCTACTGAACTTCGGGGTGATCGGTCCCAACAAGGAGGAGGTGAGTGCCTGGGCAGCGT TTATTCTCACTCACAAGCAAAGTAGGGTGGGAGGGCAAGAAAGGCAGGAGGGTAAGGGAAAGAGGTCGGC TGGTGGGCACAGTAATGTGGAGGAGAGTTGGGGAGGGAGACCTCGGACCCGTGCAGCCAGTTGTCTAAAC ATCCTTGGGTGGATGCACGGAGGGGCGAATGAACGAACAAGCGTGCGTACACGTGCAGAGATGTGCAGAG ACGTGGCCAGGGGAACAGGGAAGAAGCAAGAGATAAAAATTCGAGACGGAGATGGGAGACGAGGGAGATA AGGAGATATGAGAGATAAGGAGGGAGATGGAGGGGAAACAACAGATCAAGCACAGAGGGTACCACAGAAA GATGCTGAGGTTGGACGGATAAATGAATGAGGAGGAAAAGCACTGACTGGGGGGGGGGGGCTGGCAAAGA GCGGGGAGGCTTCTCCTTTGTGGTGAGTCTGTCTACTAACCTACTTCTTTCCCTACACAGAAGTTCCCAA ATGGGCTCCCTCTCATCAGTTCCATGGCCCAGACCCTCACACTCAGTAAGTGTTCCCAAGCCTCTCTCTT AATTTAGGATGGGGGGCGGGGGACTTAAAGCTTTGGTTTGGGAGGAAAGGGAATAGGGGTCTAACTACAC AGATGCTTGCTGGGAAACCTAAGGGTCTCATCTCCGCCTTTGTCCCCTTCCAGGATCATCTTCTCAAAAC TCGAGTGACAAGCCCGTAGCCCACGTCGTAGGTAAGTTTCTTCGCATGTGCCTTGGGGGGGGGGGTGTGA CAGGGCAGGATTTTGGGGTCGTGCCAGGCTGAGAGAAGACAAGGGCTCTCAGAGACAGCAGGTGAGAGAG TCAGAGCGGTGATTCAAAGGCAAGGCATTAGGAGGCCACCCCGGACCTCGTAGCCAATGGGACGTGGAAA GACCAGAGGGCGCAGGAACCGGAAGTGAAGTGTGGGTAGAAGTTGAGGTTCAGGATGTGGAGTGTGAACT AAGAGGGTGACACTGACTCAATTCTCCCTCCCTCAGCAAACCACCAAGCGGAGGAGCAGCTGGAGTGGCT GAGCCAGCGTGCCAACGCCCTCCTGGCCAATGGCATGGATCTCAAAGACAACCAACTGGTGGTACCAGCA GATGGGCTGTACCTTATCTACTCCCAGGTTCTCTTCAAGGGACAAGGCTGCCCCGACTACGTGCTCCTCA CCCACACCGTCAGCCGATTTGCCATTTCATACCAGGAGAAAGTCAGCCTCCTCTCTGCCATCAAGAGCCC TTGCCCTAAGGACACCCCTGAGGGAGCTGAGCTCAAGCCCTGGTATGAGCCCATGTACCTGGGAGGAGTC TTCCAGCTGGAGAAGGGGGACCTGCTCAGCGCTGAGGTCAACCTGCCCAAGTACTTAGACATCACGGAGT CCGGGCAGGTCTACTTTGGAGTCATTGCTCTGTGAGGCGACTGGCGTGTTCATCCGTTCTCTACCCAGCC CCTGTCCCCGACTCTGACCCCCATTACTCTGACCCCTTTATCGTCTACTCCTCAGAGCCCCCAATCTGTG TCCTTCTAACTTAGAAAGGGAATTGTGGCTCTGGGTCCAACTCCGGGCTCAGAATTTCCAACAACTACGA TGCTCAGAAACACACGAGACGCTGAAGTAGTGGCCTGGATTGCGGGCTGCTCATGAGCCGCCACCGGCAA GGATTCCAATGGGCTTTCGGAACTCACTGGATCCCGGAATGTCGATGCCTGAGTGGATCGGGGGAGTGGA GGGGGGAGTGGATCAGGCTGCCTCTGGCTCACAAGGCTGCTGAAGATGTCTCAGGCCTCCCTTCCTTCCT TCCTTCCCTCCCTCAGAGCTTCCCAGACTGTTCCCTGAGGCACAGCGCCCAGCCTTCCTTACGGAACCCC CTCTATTTATAATTGCACCTGTGACTATTTATTTATTATTTATTATTTATTTATTTGCTTATGAATGTAT TTATTTGGAAGGCCGGGGCGTCCTGGAGGACCCAGCGTTGGGAAGCTGTCTTCAGGCCAACATGTTTTCT GTGAAAACGGAGCTAAACTACCAGCTATCCCCATCTGGTCCCCCACCCCTGCCTCGTTGCCTCCCCCCTT TTCTTTTGCTTATGTTTAAAACAAGATATTTATCTAACCCAGTTGTCTTAATAATGCTGATTTGGTGACC AGGCTGTCGCTACATCACTGAACCTCTGCTCCCCACGGGAGCCGTGACTGTAATCGCCCTACGGGTCATT GAGAGAAATAAAGTTCGCTTGGAAAAGAA >gi|6981662|ref|NP_036807.1| tumor necrosis factor [Rattus norvegicus] MSTESMIRDVELAEEALPKKMGGLQNSRRCLCLSLFSFLLVAGATTLFCLLNFGVIGPNKEEKFPNGLPL ISSMAQTLTLRSSSQNSSDKPVAHVVANHQAEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLIYSQ VLFKGQGCPDYVLLTHTVSRFAISYQEKVSLLSAIKSPCPKDTPEGAELKPWYEPMYLGGVFQLEKGDLL SAEVNLPKYLDITESGQVYFGVIAL Other Ho et al., 2006 journal Ho PP, Higgins JP, Kidd BA, Tomooka B, Digennaro C, Lee LY, de Vegvar HE, Steinman L, Robinson WH 2006 39 8 675-682 Autoimmunity Mayo Clinic - Arthritis website http://www.mayoclinic.com/health/arthritis/DS01122 Quintana et al., 2002 journal Quintana FJ, Carmi P, Mor F, Cohen IR 2002 169 6 3422-3428 Journal of immunology (Baltimore, Md. : 1950) Ragno et al., 1997 journal Ragno S, Colston MJ, Lowrie DB, Winrow VR, Blake DR, Tascon R 1997 40 2 277-283 Arthritis and rheumatism Santos-Junior et al., 2005 journal Santos-Junior RR, Sartori A, De Franco M, Filho OG, Coelho-Castelo AA, Bonato VL, Cabrera WH, Ibañez OM, Silva CL 2005 16 11 1338-1345 Human gene therapy Song et al., 2009 journal Song X, Liang F, Liu N, Luo Y, Xue H, Yuan F, Tan L, Sun Y, Xi C, Xi Y 2009 27 5 690-700 Vaccine