Human cytomegalovirus 10359 Humans Also known as human herpesvirus 5. Cytomegalovirus (CMV) is a common virus that can infect almost anyone. Most people don't know they have CMV because it rarely causes symptoms. However, if you're pregnant or have a weakened immune system, CMV is cause for concern. Once infected with CMV, your body retains the virus for life. However, CMV usually remains dormant if you're healthy. CMV spreads through body fluids, such as blood, saliva, urine, semen and breast milk. People with weak immune systems have a greater risk of becoming ill from CMV. If you're pregnant and develop an active infection, you can pass the virus to your baby. There's no cure for CMV, but drugs can help treat newborns and people with weak immune systems (Mayo Clinic - CMV). Baboon Papio cynocephalus 9556 Bank vole Clethrionomys glareolus 447135 Bear Ursus americanus 9643 Birds Passeroidea 175121 Brown Trout Salmo trutta 8032 Buffalo Bison bison 9901 Carnivores Vulpes 9625 Cat Felis catus 9685 Catfishes Siluriformes 7995 Cattle Bos taurus 9913 Chicken Gallus gallus 9031 Chimpanzee Pan troglodytes 9598 chinchillas Chinchillidae 10150 Copper Pheasant Syrmaticus soemmerringii 9067 Deer Cervus elaphus 9860 Deer mouse Peromyscus maniculatus 10042 Dog Canis familiaris 9615 Ducks Anas 8835 Ferret Mustela putorius furo 9669 Fish Hyperotreti 117565 Gerbil Gerbillina 10045 Goat Capra hircus 9925 Gray wolf Canis lupus 9612 Guinea pig Cavia porcellus 10141 Hamster Mesocricetus auratus 10036 Horse Equus caballus 9796 Human Homo sapiens 9606 Macaque Macaca fascicularis 9541 Mongolian Gerbil Meriones unguiculatus 10047 Monkey Platyrrhini 9479 Mouse Mus musculus 10090 None None Parrot Psittacidae 9224 Pig Sus scrofa 9823 Rabbit Oryctolagus cuniculus 9986 Rainbow trout Oncorhynchus mykiss 8022 Rat Rattus 10114 Raven Corvus corax 56781 sei whale Balaenoptera borealis 9768 Sheep Ovis aries 9940 Squirrel Spermophilus richardsonii 37591 Tree shrew Tupaiidae 9393 Trouts, salmons & chars Salmoninae 504568 Turkey Meleagris gallopavo 9103 Vole Microtus ochrogaster 79684 Water buffalo Bubalus bubalis 391902 Human cytomegalovirus DNA vaccine pcGB VO_0004599 DNA vaccine Research pcDNA3 [Ref2792:Hwang et al., 1999] Intramuscular injection (i.m.) Intramuscular injection (i.m.) DNA vaccine construction VO_0003057 Neutralizing antibody was developed, and the percent reduction of input infectivity in 1:100 diluted sera was 74.5% in three-times immunized groups. The induction of neutralizing antibody with HCMV gB in this study might be useful to attenuate or prevent HCMV infection (Hwang et al., 1999). Human cytomegalovirus DNA vaccine VCL-CB01 encoding phosphoprotein 65 and gB VO_0004341 DNA vaccine Clinical trial Intramuscular injection (i.m.) CRL-1005 and BAK (Schleiss, 2009) Intramuscular injection (i.m.) DNA vaccine construction This DNA vaccine expressed the major hCMV surface glycoprotein B (Schleiss, 2009). DNA vaccine construction VCL-CB01 increased T-cell responses compared with placebo (Schleiss, 2009). VO_0000286 VO_0003057 Preclinical investigation of the hCMV gB/pp65 DNA vaccine was initially conducted in mice. When formulated in PBS, lone gB and pp65 plasmids were highly immunogenic, but vaccination with the bivalent vaccine reduced immune responses to each antigen by 2.8- and 4-fold of the lone values, respectively. However, formulating the bivalent vaccine with 02A significantly (p = 0.048) increased the antigen-specific immune responses relative to those induced with the bivalent vaccine in PBS, as well as completely abrogating a decrease in pp65-specific T-cell responses (Schleiss, 2009). licensed Cytomegalovirus infection human vaccine Generic Unknown VO_0001227 Subunit vaccine Licensed A generic representation of vaccines utilized to prevent human cytomegalovirus infection in humans, most commonly based on subunit formulations such as glycoprotein B or other viral protein antigens. These vaccines aim to elicit protective immune responses without using live virus components. Glycoprotein B Human betaherpesvirus 5 3077424 52139241 HHV5wtgp060 AY446894 YP_081514 10359 82065 84788 - envelope glycoprotein B 7.31 94542.1 907 >NC_006273.2:82065-84788 Human herpesvirus 5 strain Merlin, complete genome TTCAGACGTTCTCTTCTTCGTCAGAGTCTTTCAAGTGTCGGTAGCCGTTTTTGCGATGTCGCAGTCGGTC TAGTAGGTTGGGCTTCTGTCCCTTGTCCTGCGTGCCAGTCCGTCCGTCCAAAGAATCTGTACCGTTCTGC TGCGCTCGCTGCTCTGCGTCCAGACGGGCCAGGGCCAGAAGCATCTGGTAAGCCTGCTCGTTGGTGTAAG GCGGAGCCGCCGTGGATGCATCAGACGACGGTGGTCCCGGTCCTTTGCGACCAGAATTATAAACACTTTC CTCGTAGGAAGGCGGAGCCTGTAACGACGTGTCTTTGGTGCTGCCCGACGTCACGGTGGTCCCGTCGGCG GACACCAGATAGGGAAAGAGGTTCTGCAGCGGCTGCGTGCACAAACGCCGCTGTCGAGTATAGATCAAAT AAGTGATAATGACTACAGCTATGGCCACGAGGATGATGGTGAACGCTCCGAAGGGGTTTTTGAGGAAGGT GGCAACGCCTTCGACCACGGAGGCCACCGCGCCACCCACGGCCCCAATGGCTACGCCAACGGCCTTTCCC GCGGCGCCCAGGCCGCTCATGAGGTCGTCCAGACCCTTGAGGTAGGGCGGTAGCGGGTCGACTACCTTGT CCTCCACGTACTTTACCCGCTGCTTGTACGAGTTGAATTCGCGCATGATCTCTTCGAGGTCAAAAACGTT GCTGGAACGCAGCTCTTTCTGCGAGTAAAGTTCCAGTACCCTGAAGTCGGTATTTTCCAGCGGGTCGATA TCCAGGGCGATCATGCTGTCGACGGTGGAGATACTGCTGAGGTCAATCATGCGTTTGAAGAGGTAGTCCA CGTACTCGTAGGCCGAGTTCCCGGCGATGAAGATCTTGAGGCTGGGAAGCTGACATTCCTCAGTGCGGTG GTTGCCCAACAGGATTTCGTTGTCCTCGCCCAGTTGACCGTACTGCACGTACGAGCTGTTGGCGAAATTA AAGATGACCACGGGTCGTGAGTAGCAGCGTCCTGGCGACTCCTTCACGTTCATATCACGCAGCACCTTGA CGCTGGTTTGGTTGATGGTCACGCAGCTGGCCAGGCCCAAGACATCACCCATGAAACGCGCGGCAATCGG TTTGTTGTAAATGGCCGAGAGAATGGCTGACGGGTTGATCTTGCTGAGTTCCTTGAAGACCTCTAGGGTG CGCCGTTGATCCACACACCAGGCTTCTGCGATTTGCGCCAGCGCCCGGTTGATGTAACCGCGCAACGTGT CATAGGTGAACTGCAGCTGGGCGTAGACCAGATTGTGCACCGATTCCATGTTGGATAAATGAGTTGCATT GTTGCCATCTGTACTTCTTTTGGTTCTATTATGAGTAAGATTCAGACTGGAGCGGTTGGCCAAACGTTCG AGTTCCACCAGAGATTTTTGCTTGATACCTTGCCAGAACACTACCAAACCACCAGTGGTTTCAAAGACGG ACACGTTTCCATATTTTTCATATGTTTGATTGTATGAAGTATTGAAAATCTGCTGTAACTTATTTATAGC CTCATCACGTACGCAGTCCAGCGCAGAGTCGGACATGTTCACCTCTTGCTTCTTAGATAAGAAAGTGGCG GTCATTTTGGCAGAAGAAAAGTGATACGAGTCCTCGGCTTCGGAACGAATGGTGCGTTCCGAGGCTTCCC AGAAAGTGAGTTGACAAGTGACATTCTTTTCGTCCTGTATATCCCAGGAGATCACCGAGTCCGCACGTTC AAGAAAAGCCACCAACCTGTGGGTCTCTAACGCAGAATTCGGTCTTCCAAAGTCGGAGACGATAGTGTAG TTCGGAAAAATGAAAAACTTGTCGGCGTTTTCTCCAAAGTAGCTGGCATTGCGATTGGTTCCGTTGTAGA AAGGAGAAATGTCAACCACGTCACCCGTGGAAGTGGCGAAAAAATGATAAGGATATTTGGAGCGCGCAGT AGTGATGGTCACCATACAATTCAGATTACAGGTCTCACGATAGAGCCAGGTGCTGCCGCGGCTGTGCCAT TGATCCTTGACCGTCACGTAACGGGTACTGTGGGTGTTGGAATAATCGTCGGGCATTAATTGCATGGTTT TGTTTTCATAGCTGTCCCTATGATAAGCCACGAAAACCGTGCCTGCTATAACGCGGCTGTAGGAACTGTA GCACTGACTGTGGCTGTTGATATGATGAATCTCCCACATAGGAGGCGCCACGTATTCCGTGTTGCTGCCC AGCAGATAAGTGGTGTGGATGTAAGCGTAGCTACGACGAAACGTCAAAACCTTCTGGTAGACTCGTACCT TAAAGGTGTGCGCGACGATGTTGCGTTTGTAGACCACCATGATGCCCTCGTCCAGGTCTTCATTGATGGG CTTCATCGAGGTGCAGACGATATTACGTTCAAAGCGAATAAGATCCGTACCCTGGGCCATAGAACACACG CGATAGGGGTACTTGGTGGTATTGACCCCCACCACATCTCCGTACTTGAGGGTAGTGTTGTAGATGGTCT CGTTAACACCATGGCTGACCGTTTGGGAAGAAGTTACGCGTTGAGAGACTGAACCGGATCGAGAGTGAGC AGCAGACGTCGTATGAGAGGAATGGTGACTGTGAGTAGCAGAAGTTCCACGAGTAGAAGATGAGGAAACC GCAGCACCCAGACAGACGATACACAAGTTAACGCAGACTACCAGGCACCAGATCCTGGATTCCA >YP_081514.1 envelope glycoprotein B [Human betaherpesvirus 5] MESRIWCLVVCVNLCIVCLGAAVSSSSTRGTSATHSHHSSHTTSAAHSRSGSVSQRVTSSQTVSHGVNET IYNTTLKYGDVVGVNTTKYPYRVCSMAQGTDLIRFERNIVCTSMKPINEDLDEGIMVVYKRNIVAHTFKV RVYQKVLTFRRSYAYIHTTYLLGSNTEYVAPPMWEIHHINSHSQCYSSYSRVIAGTVFVAYHRDSYENKT MQLMPDDYSNTHSTRYVTVKDQWHSRGSTWLYRETCNLNCMVTITTARSKYPYHFFATSTGDVVDISPFY NGTNRNASYFGENADKFFIFPNYTIVSDFGRPNSALETHRLVAFLERADSVISWDIQDEKNVTCQLTFWE ASERTIRSEAEDSYHFSSAKMTATFLSKKQEVNMSDSALDCVRDEAINKLQQIFNTSYNQTYEKYGNVSV FETTGGLVVFWQGIKQKSLVELERLANRSSLNLTHNRTKRSTDGNNATHLSNMESVHNLVYAQLQFTYDT LRGYINRALAQIAEAWCVDQRRTLEVFKELSKINPSAILSAIYNKPIAARFMGDVLGLASCVTINQTSVK VLRDMNVKESPGRCYSRPVVIFNFANSSYVQYGQLGEDNEILLGNHRTEECQLPSLKIFIAGNSAYEYVD YLFKRMIDLSSISTVDSMIALDIDPLENTDFRVLELYSQKELRSSNVFDLEEIMREFNSYKQRVKYVEDK VVDPLPPYLKGLDDLMSGLGAAGKAVGVAIGAVGGAVASVVEGVATFLKNPFGAFTIILVAIAVVIITYL IYTRQRRLCTQPLQNLFPYLVSADGTTVTSGSTKDTSLQAPPSYEESVYNSGRKGPGPPSSDASTAAPPY TNEQAYQMLLALARLDAEQRAQQNGTDSLDGRTGTQDKGQKPNLLDRLRHRKNGYRHLKDSDEEENV Protective antigen UL83 Human herpesvirus 5 270355835 CDD:283448 10359 ? tegument protein pp65 7.27 58927.11 631 unpassaged strain in the original clinical sample; acronym: HCMV; acronym: HHV-5 >ACZ79994.1 tegument protein pp65 [Human betaherpesvirus 5] MESRGRRCPDMISVLGPISGHVLKAVFSRGDTPVLPHETRLLQTGIHVRVSQPSLILVSQYTPDSTPCHR GDNQLQVQHTYFTGSEVENVSVNVHNPTGRSICPSQEPMSIYVYALPLKMLNIPSINVHHYPSAAERKHR HLPVADAVIHASGKQMWQARLTVSGLAWTRQQNQWKEPDVYYTSAFVFPTKDVALRHVVCAHELVCSMEN TRATKMQVIGDQYVKVYLESFCEDVPSGKLFMHVTLGSDVEEDLTMTRNPQPFMRPHERNGFTVLCPKNM IIKPGKISHIMLDVAFTSHEHFGLLCPKSIPGLSISGNLLMNGQQIFLEVQAIRETVELRQYDPVAALFF FDIDLLLQRGPQYSEHPTFTSQYRIQGKLEYRHTWDRHDEGAAQGDDDVWTSGSDSDEELVTTERKTPRV TGGGAMAGASTSAGRKRKSASSATACTAGVMTRGRLKAESTVAPEEDTDEDSDNEIHNPAVFTWPPWQAG ILARNLVPMVATVQGQNLKYQEFFWDANDIYRIFAELEGVWQPAAQPKRRRHRQEALPGPCIASTPKKHR G Protective antigen Hwang et al., 1999 journal Hwang ES, Kwon KB, Park JW, Kim DJ, Park CG, Cha CY 1999 43 3 307-310 Microbiology and immunology Mayo Clinic - CMV website http://www.mayoclinic.com/health/cmv/DS00938 Tang et al., 2017 journal Tang A, Freed DC, Li F, Meschino S, Prokop M, Bett A, Casimiro D, Wang D, Fu TM 2017 13 12 2763-2771 Human vaccines & immunotherapeutics