Leptospira spp. 171 Leptospirosis Leptospirosis is transmitted by the urine of an infected animal and is contagious as long as it is still moist. Although rats, mice and moles are important primary hosts, a wide range of other mammals including dogs, deer, rabbits, hedgehogs, cows, sheep, raccoons, possums, skunks, and certain marine mammals are able to carry and transmit the disease as secondary hosts (Wiki: Leptospirosis). Leptospirosis (also known as Weil's disease, Weil's syndrome, canicola fever, canefield fever, nanukayami fever, 7-day fever, Rat Catcher's Yellows, Fort Bragg fever, and Pretibial fever) is a bacterial zoonotic disease caused by spirochaetes of the genus Leptospira that affects humans and a wide range of animals, including mammals, birds, amphibians, and reptiles. The disease was first described by Adolf Weil in 1886 when he reported an "acute infectious disease with enlargement of spleen, jaundice and nephritis". Leptospira was first observed in 1907 from a post mortem renal tissue slice. In 1908, Inada and Ito first identified it as the causative organism and in 1916 noted its presence in rats. Though recognised among the world's most common zoonoses, leptospirosis is a relatively rare bacterial infection in humans. The infection is commonly transmitted to humans by allowing water that has been contaminated by animal urine to come in contact with unhealed breaks in the skin, the eyes, or with the mucous membranes. Outside of tropical areas, leptospirosis cases have a relatively distinct seasonality with most of them occurring August–September/February–March. Leptospirosis is caused by a spirochaete bacterium called Leptospira spp. that has at least 5 serovars of importance in the United States and Canada causing disease in dogs (Icterohaemorrhagiae, Canicola, Pomona, Grippotyphosa, and Bratislava).There are other (less common) infectious strains. Genetically different leptospira organisms may be identical serologically and vice versa. Hence, an argument exists on the basis of strain identification. The traditional serologic system is seemingly more useful from a diagnostic and epidemiologic standpoint at the moment (which may change with further development and spread of technologies like PCR). Leptospirosis is transmitted by the urine of an infected animal and is contagious as long as it is still moist. Although rats, mice and moles are important primary hosts, a wide range of other mammals including dogs, deer, rabbits, hedgehogs, cows, sheep, raccoons, possums, skunks, and certain marine mammals are able to carry and transmit the disease as secondary hosts. Dogs may lick the urine of an infected animal off the grass or soil, or drink from an infected puddle. There have been reports of "house dogs" contracting leptospirosis apparently from licking the urine of infected mice that entered the house. The type of habitats most likely to carry infective bacteria are muddy riverbanks, ditches, gullies, and muddy livestock rearing areas where there is regular passage of either wild or farm mammals. There is a direct correlation between the amount of rainfall and the incidence of leptospirosis, making it seasonal in temperate climates and year-round in tropical climates. Leptospirosis is also transmitted by the semen of infected animals. Slaughterhouse workers may contract the disease through contact with infected blood or body fluids. Humans become infected through contact with water, food, or soil containing urine from these infected animals. This may happen by swallowing contaminated food or water, or through skin contact. The disease is not known to be spread from person to person and cases of bacterial dissemination in convalescence are extremely rare in humans. Leptospirosis is common among water-sport enthusiasts in specific areas as prolonged immersion in water is known to promote the entry of the bacteria. Surfers and whitewater paddlers are at especially high risk in areas that have been shown to contain the bacteria, and can contract the disease by swallowing contaminated water, splashing contaminated water into their eyes or nose, or exposing open wounds to infected water. Occupations at risk include veterinarians, slaughterhouse workers, farmers, sewer workers, and people working on derelict buildings. Rowers are also sometimes known to contract the disease (Wiki: Leptospirosis). Baboon Papio cynocephalus 9556 Bank vole Clethrionomys glareolus 447135 Bear Ursus americanus 9643 Birds Passeroidea 175121 Brown Trout Salmo trutta 8032 Buffalo Bison bison 9901 Carnivores Vulpes 9625 Cat Felis catus 9685 Catfishes Siluriformes 7995 Cattle Bos taurus 9913 Chicken Gallus gallus 9031 Chimpanzee Pan troglodytes 9598 chinchillas Chinchillidae 10150 Copper Pheasant Syrmaticus soemmerringii 9067 Deer Cervus elaphus 9860 Deer mouse Peromyscus maniculatus 10042 Dog Canis familiaris 9615 Ducks Anas 8835 Ferret Mustela putorius furo 9669 Fish Hyperotreti 117565 Gerbil Gerbillina 10045 Goat Capra hircus 9925 Gray wolf Canis lupus 9612 Guinea pig Cavia porcellus 10141 Hamster Mesocricetus auratus 10036 Horse Equus caballus 9796 Human Homo sapiens 9606 Macaque Macaca fascicularis 9541 Mongolian Gerbil Meriones unguiculatus 10047 Monkey Platyrrhini 9479 Mouse Mus musculus 10090 None None Parrot Psittacidae 9224 Pig Sus scrofa 9823 Rabbit Oryctolagus cuniculus 9986 Rainbow trout Oncorhynchus mykiss 8022 Rat Rattus 10114 Raven Corvus corax 56781 sei whale Balaenoptera borealis 9768 Sheep Ovis aries 9940 Squirrel Spermophilus richardsonii 37591 Tree shrew Tupaiidae 9393 Trouts, salmons & chars Salmoninae 504568 Turkey Meleagris gallopavo 9103 Vole Microtus ochrogaster 79684 Water buffalo Bubalus bubalis 391902 Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4019.00) Wyeth, Colorado Serum Company VO_0001880 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4059.00) Colorado Serum Company VO_0001881 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Hardjo-Pomona Bacterin (USDA: 4069.20) Wyeth VO_0001882 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4089.00) Colorado Serum Company, Heska Corporation VO_0001883 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4089.20) Boehringer Ingelheim Vetmedica, Inc., Heska Corporation, Merial, Inc. VO_0001884 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4129.00) Colorado Serum Company, Heska Corporation VO_0001892 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4179.00) Colorado Serum Company VO_0001893 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4209.00) Colorado Serum Company, Heska Corporation VO_0001894 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4145.20) Novartis Animal Health US, Inc. VO_0001903 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4145.21) Heska Corporation VO_0001904 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4335.20) Heska Corporation VO_0001907 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4336.30) Heska Corporation VO_0001908 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4141.20) Boehringer Ingelheim Vetmedica, Inc., Intervet Inc. VO_0001914 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4339.00) Colorado Serum Company, Heska Corporation VO_0001915 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4359.00) Colorado Serum Company VO_0001916 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Hardjo-Pomona Bacterin (USDA: 4399.20) Wyeth VO_0001917 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.00) Colorado Serum Company, Heska Corporation VO_0001918 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.20) Boehringer Ingelheim Vetmedica, Inc., Merial, Inc. VO_0001919 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.21) Heska Corporation VO_0001920 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4435.20) Novartis Animal Health US, Inc. VO_0001922 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4560.24) Pfizer, Inc. VO_0001931 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4560.25) Pfizer, Inc. VO_0001932 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Haemophilus Somnus-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4489.30) Boehringer Ingelheim Vetmedica, Inc. VO_0001933 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4439.00) Colorado Serum Company VO_0001934 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4439.20) Wyeth, Heska Corporation, Merial, Inc. VO_0001935 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4479.00) Colorado Serum Company VO_0001936 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4509.00) Colorado Serum Company, Heska Corporation VO_0001937 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.20) Novartis Animal Health US, Inc. VO_0001951 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.22) Novartis Animal Health US, Inc. VO_0001952 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B5.20) Novartis Animal Health US, Inc. VO_0001953 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.20) Novartis Animal Health US, Inc. VO_0001954 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.21) Novartis Animal Health US, Inc. VO_0001955 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D7.20) Wyeth, Boehringer Ingelheim Vetmedica, Inc., Novartis Animal Health US, Inc. VO_0001959 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D7.22) Novartis Animal Health US, Inc. VO_0001960 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.20) Wyeth, Boehringer Ingelheim Vetmedica, Inc., Merial, Inc., Novartis Animal Health US, Inc. VO_0001962 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.21) Wyeth VO_0001963 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.22) Wyeth VO_0001964 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4466.20) Novartis Animal Health US, Inc. VO_0001965 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4466.21) Novartis Animal Health US, Inc. VO_0001966 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona-Mannheimia Haemolytica Bacterin (USDA: 4475.20) Wyeth VO_0001967 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.21) Heska Corporation VO_0001975 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.22) Pfizer, Inc. VO_0001976 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.20) Heska Corporation VO_0001978 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.22) Pfizer, Inc. VO_0001979 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.25) Pfizer, Inc. VO_0001980 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.30) Heska Corporation VO_0001981 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.20) Boehringer Ingelheim Vetmedica, Inc., Intervet Inc. VO_0001982 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.22) Pfizer, Inc. VO_0001983 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.23) Pfizer, Inc. VO_0001984 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.25) Pfizer, Inc. VO_0001985 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.20) Boehringer Ingelheim Vetmedica, Inc. VO_0001990 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.21) Boehringer Ingelheim Vetmedica, Inc. VO_0001991 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.23) Boehringer Ingelheim Vetmedica, Inc. VO_0001992 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.24) Boehringer Ingelheim Vetmedica, Inc. VO_0001993 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.20) Wyeth, Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., Heska Corporation VO_0001994 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.21) Pfizer, Inc. VO_0001995 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.22) Wyeth, Intervet Inc. VO_0001996 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.25) Pfizer, Inc. VO_0001997 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.00) Heska Corporation VO_0001998 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.01) Boehringer Ingelheim Vetmedica, Inc. VO_0001999 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.23) Boehringer Ingelheim Vetmedica, Inc. VO_0002000 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.24) Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc. VO_0002001 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.26) Pfizer, Inc. VO_0002002 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Hardjo Bacterin (USDA: 4L49.20) Pfizer, Inc. VO_0002003 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.20) Heska Corporation VO_0002013 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.26) Pfizer, Inc. VO_0002014 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.30) Heska Corporation VO_0002015 Live, attenuated vaccine Licensed USA Bovine Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 45B5.21) Pfizer, Inc. VO_0002023 Inactivated or "killed" vaccine Licensed USA Bovine Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4595.21) Pfizer, Inc. VO_0002025 Inactivated or "killed" vaccine Licensed USA Bovine Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4595.25) Pfizer, Inc. VO_0002026 Inactivated or "killed" vaccine Licensed USA Bovine Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4599.00) Colorado Serum Company VO_0002027 Live, attenuated vaccine Licensed USA Canine Coronavirus Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 47E5.21) Wyeth VO_0002244 Inactivated or "killed" vaccine Licensed USA Canine Coronavirus Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 47E5.20) Wyeth VO_0002243 Inactivated or "killed" vaccine Licensed USA Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46E5.21) Wyeth VO_0002222 Inactivated or "killed" vaccine Licensed USA Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46E5.24) Wyeth VO_0002224 Inactivated or "killed" vaccine Licensed USA Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46E5.23) Wyeth VO_0002223 Inactivated or "killed" vaccine Licensed USA Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46E5.25) Wyeth VO_0002225 Inactivated or "killed" vaccine Licensed USA Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46E5.20) Intervet Inc. VO_0002221 Inactivated or "killed" vaccine Licensed USA Canine Coronavirus Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46D5.27) Wyeth VO_0002220 Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4629.27) Wyeth VO_0002207 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4629.20) Pfizer, Inc. VO_0002206 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46B9.21) Wyeth VO_0002219 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.25) Wyeth VO_0002231 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.29) Wyeth VO_0002234 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47L9.20) Pfizer, Inc. VO_0002246 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.21) Wyeth VO_0002230 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.26) Wyeth VO_0002232 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.27) Wyeth VO_0002233 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.20) Intervet Inc., Pfizer, Inc. VO_0002226 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.22) Pfizer, Inc. VO_0002227 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.20) Intervet Inc. VO_0002229 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46L9.27) Wyeth VO_0002236 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.R1) Merial, Inc. VO_0002235 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46P9.27) Wyeth VO_0002237 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4659.20) Pfizer, Inc. VO_0002218 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4637.29) Wyeth VO_0002211 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4639.25) Wyeth VO_0002214 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47K1.20) Intervet Inc., Pfizer, Inc. VO_0002245 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.27) Wyeth VO_0002215 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.28) Wyeth VO_0002216 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.20)_ Intervet Inc., Pfizer, Inc. VO_0002208 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.22) Intervet Inc. VO_0002209 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.23) Pfizer, Inc. VO_0002210 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.21) Wyeth, Pfizer, Inc. VO_0002212 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.22) Pfizer, Inc. VO_0002213 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J8.20) Boehringer Ingelheim Vetmedica, Inc. VO_0002228 Live, attenuated vaccine Licensed USA Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.R1) Merial, Inc. VO_0002217 Live, attenuated vaccine Licensed USA Canine Distemper-Hepatitis-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 47P9.22) Boehringer Ingelheim Vetmedica, Inc. VO_0002247 Live, attenuated vaccine Licensed USA Canine Parainfluenza Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 47A9.20) Intervet Inc. VO_0004212 Live, attenuated vaccine Licensed USA Canine Parvovirus Modified Live Virus Vaccine-Leptospira Canicola Icterohaemorrhagiae Bacterin (USDA: 47B1.20) Boehringer Ingelheim Vetmedica, Inc. VO_0002240 Licensed USA Leptospira interrogans DNA vaccine ompL1-pcDNA3.1(+) VO_0004562 DNA vaccine Research pcDNA3.1(+) [Ref2683:Maneewatch et al., 2007] Intramuscular injection (i.m.) Intramuscular injection (i.m.) DNA vaccine construction VO_0003057 The vaccine was shown to confer the delay in the death time and reduced morbidity in the vaccinated animals when compared to animals immunized with the plasmid alone or PBS. Hamsters of group 2 (mock) and group 3 (positive leptospirosis) were all dead between days 5 and 6 post-challenge. For the vaccinated group, two hamsters were dead on day 9, one each died on days 11 and 18, respectively. Two hamsters survived the lethal Leptospira challenge until day 21 when they were sacrificed (Maneewatch et al., 2007). Leptospira interrogans DNA vaccine pTARGET/ LigBrep VO_0004563 DNA vaccine Research pTARGET [Ref2684:Forster et al., 2013] Intramuscular injection (i.m.) Intramuscular injection (i.m.) DNA vaccine construction The vaccine induced an IgG antibody response and, additionally, conferred sterilizing immunity in 80% of the surviving animals (Forster et al., 2013). VO_0003057 Immunization with a DNA vaccine encoding LigBrep resulted in the survival of 5/8 (62.5%) hamsters against lethal infection (P < 0.05). None of the control hamsters or animals immunized with the other vaccine preparations survived (Forster et al., 2013). licensed Leptospirosis human vaccine Generic Unknown VO_0000391 Inactivated or "killed" vaccine Licensed A generic representation of vaccines utilized to prevent leptospirosis in humans, most commonly formulated as inactivated (killed) whole-cell preparations of Leptospira species. These vaccines aim to induce protective immunity without the risk of causing disease. Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4989.00) Colorado Serum Company VO_0002295 Live, attenuated vaccine Licensed USA Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.20) Wyeth, Pfizer, Inc. VO_0002321 Inactivated or "killed" vaccine Licensed USA Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.21) Intervet Inc., Pfizer, Inc. VO_0002322 Inactivated or "killed" vaccine Licensed USA Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.22) Pfizer, Inc. VO_0002323 Inactivated or "killed" vaccine Licensed USA Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.01) Wyeth VO_0002277 Inactivated or "killed" vaccine Licensed USA Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.20) Pfizer, Inc., Novartis Animal Health US, Inc. VO_0002278 Inactivated or "killed" vaccine Licensed USA Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.21) Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., Pfizer, Inc., Novartis Animal Health US, Inc. VO_0002279 Inactivated or "killed" vaccine Licensed USA Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.22) Pfizer, Inc. VO_0002280 Inactivated or "killed" vaccine Licensed USA Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.01) Wyeth VO_0002292 Inactivated or "killed" vaccine Licensed USA Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.20) Novartis Animal Health US, Inc. VO_0002293 Inactivated or "killed" vaccine Licensed USA Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.22) Novartis Animal Health US, Inc. VO_0002294 Inactivated or "killed" vaccine Licensed USA Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4960.00) Boehringer Ingelheim Vetmedica, Inc. VO_0002291 Live, attenuated vaccine Licensed USA Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.22) Pfizer, Inc. VO_0002309 Inactivated or "killed" vaccine Licensed USA Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.23) Pfizer, Inc. VO_0002310 Inactivated or "killed" vaccine Licensed USA Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.24) Pfizer, Inc. VO_0002311 Inactivated or "killed" vaccine Licensed USA Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.22) Pfizer, Inc. VO_0002312 Inactivated or "killed" vaccine Licensed USA Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.23) Pfizer, Inc. VO_0002313 Inactivated or "killed" vaccine Licensed USA Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.24) Pfizer, Inc. VO_0002314 Inactivated or "killed" vaccine Licensed USA Porcine Reproductive & Respiratory Syndrome-Parvovirus Reproductive Form, Modified Live & Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4P19.20) Boehringer Ingelheim Vetmedica, Inc. VO_0002324 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Trichomonas Foetus Vaccine, Killed Protozoa-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4990.00) Wyeth VO_0002296 Licensed USA ligB Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 2771118 45656362 LIC10464 AE016823 YP_000448 267671 I 526394 532066 - hypothetical protein 7.03 190366.08 1890 Big; identified by sequence similarity; ORF located using Blastx/Glimmer >NC_005823.1:526394-532066 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130, chromosome I, complete sequence ATTATTGATTCTGTTGTCTGTAAATTTTGACCGGTTTATTTTTGTTTCCTACGCTTATATATACGAAATT TACACCAAAATTCATTCCGGATATAGCCGAATAAATTTGACGATTGGTAACGTCTCTTAATCCGCCTATT CCTATAGGTTCCCAGTTGTGTGATGAACTTCCAGGATTTTCAAGATTTGTTCTCCAGATTTGAATTCCGT TTTCGTTATCAAAACCTATGTAGAGATAAGATCCACTTGCAACCATCATCGTCATACTGTGATTGGAATT GTCTCCAAAGTTTGTAAATCCGGTTCCGTTATCTCCTACTAAAGACCAATCTTCTGCTTCGCAGGTTGTT GTATCGCCGGTTAGAGTCGGATCACATTTCCAAAGTTGGGGTCTTCGATTTGTATAACTTCCGTCCGTAC AACCTTCCACAGTTTGTAAACTTTGTCTGAGTCCGGAGTGATCTTCTTTCGTTACGCAGATCGTTCTTGT TACATACAATCTTCCGTTAAATTCTGCGAATTGAGAGAATGCTTTATCCGCCGGAATTAAATTCCGATAC TTTGTAAGCTCCAGTGAAAACCAATTGTTATGAGGAGAGTTATGCCACTTCGGATTGGATCTAGGTGCTG TGTCTTTCCAACTGGAACAACGATTGCTCCCCTCACAAGGACTAGGATTTGCACTGGTAGAGTGTATTAT ACTTCCATTATGTAGTGAATTTGGAAATCCTCCGTTTGCGGCGTAAAGTTTTTCTTTAAAAACGAATAGA GAATCTATTCCCACATAATAACCCCAGTTGATCGAGGAGTTATCAGATGTATAAGTTTCATAATTGTCTG CATCCTCCACGGAGAGGCCGCCGAAATAAGGCATTCTATCGATTCTAAAACGATTACCGCGGTATCCGTC AGAGGCGTCACAATTGTTTCCGGCTGCACATCTATTTTGATCGGATGTATTAAAGGTGATTTTACCGAAA TCAGGTGCGTTTAGATTTTTATTTTTTTTTGCAAAACCCACATGGATCCGATCGTCTATAACCGCGATAG ATGAAGTTCCTGCAGTCGCCGTTCCAGTAATTTCTCCCATATCGATATATTTAAAATTAAGATTTGTATC GGTATCTGAGGAATAATAGAGATAGTCGAATCTCCTTGGTCTTGAACCTGCTATAAAAATATGAGATTTT TTGTTTAATGATCCGATGGCAAAAACTCCACGTCCATCTTCGTTATCCGGACCACATCCAGTAGTAATGT CTGCACTATTGAGAGTACAACCGGTATGACCGATCGTAACGTAATTCGGAACCGGAATTCCTCCATCTCT TGAAGACGCACGGTTATCGGCATTTATATCTTTGGTAAAAGAGAAAAAAATAGATTCGGGAAAAGTTCCG TCGTAATTGAATCGAGCTGCTTGGTTTCCTTTTACATTCGGTCCTAGATAGATTTGATTGTTGTAATCTA CAAGAAAGCCGAAATCGGAACCGTCTCCAAAAGGATCTGACATGATCGGGCCATCCATAAAGTTGAGAGG GGAATTTCCACAACCTATAAAGTTGATTCTATCTTTCGGAGAAGATTGTAGGTTTTCTTGATCGAATGAA TCTCTAATTGCTCCCCAGGATTTGTTGTCAAAGCCGTCTCCGTTCAAATCATTTGCGGCGATGATCGTAT ATTGACCACCTGATTGAAGAAGGGAGTGTGTTAAACATATTTTCGAGGAGTCTGCCGGTGCTCCACCGCA TACTTTTCCATCTAAAATTCTAACGCTCGTAATACTTCCCAATGAAGACACACCTGCAAATTTATATCTG GATTCACACTGGGACGGATTTGAACATTCCACGGATTTTGTTGCTTCCTTTCCCGAATATAAAGGTTTGG AAAAAGAAACGATCACTTGGTTTAAGGAATTACAAACTGCACTTGTAAGTTTGAGTTGTTCTTTTCCTAT AAAATCAGAGTTATTTGGACAACTTAAGGAATTTGGAATGGAAGAAAGATCGTGAATTCCTTGTTTGTTG ACTACAAGTGTGTATGATTTGTTTAAGATTTGTGAATGTGAAAGTGTGATCGTAAAAGTATTTTTACTTC CTTTGATACTACTAAGAGAAAAATCTGCGGTTTGAGAATTGGAATTGAAGTCCGTATTATCTGAACAATG TCCTATAAAATTGGAACTATCAATTATTTTGTAATTGGATAAATCAAGGGCTTCCTTATTGTTTATGGAT TCTGAATATACAACTTGGATGGTAGTAGGTGATAAGGAAACTACCGATTGAACCGTTGGAGCTATCGTGT CCGTTTTGTTTACTGTGAGGATTGTATTTCCAGATACTGAACCGTAGGTCGCTGTGATTATAGAGTTTCC AGAAGCAATCCCTGTAACCAATCCTTTCGTTTTAGATGCGTTACTCACCTTTGCCTGAGATTTATTTGAG CTGGACCATGTAACCGAAGAAGTTAAATCCGCTTTGGTCCCATCCGAATACGTTCCCACCGCGAAAAATT GTTTTGATACGGTTGCGTTTATATTTGTATTGATAGGAGATATTGAAATCGAAGAAAGGGTTGCTGCGCT GACCGTTATGTCTATGTTTTCCGAGATGGAATTGTAAGTCGCAGTGATTTTGCTGTTTCCAATCTGTAAA GCGGTCGCTTTTCCCTTGGTTTCGGTCGAATTAGAGATGCTGATCGAGTCAGAATTGGAACTGGACCAGG TAACTGAATCGCTGATGTCCTGAATGGTGGAGTCTGAATAAACGCCAAGCGCAGTATATTGTTGGGTAAG TCCCTTGGCGATGTTATTGTTGACTGGATTGATTTTAATGGAATCTAACGTGGCAGCACTTACATTAAAA TTTATTTTATTACTGCTTATAGAATTGTAAATCGCAGAGATGTTGGAAGAACCTATTGAAAGTGCGGTTG CTAAACCTTTTGCATTGGCAGCGTTATTGATAGGGGCAACGTCGGATTTGGAAGAATACCAGGTCACAAG ATTCGTAATTTCTTGTTCAGAGCCATCTATAAAAGTTCCGATCGCTTTAAATTGCTGGGTCAATCCTTTG GCTATTGAACTTGAGGAAGGACTGATAGTTATACTTTTCAGTTTTAAGTCAGTGACTGTAATCGGAATTG GGGAGCTTTGGATGAATTTGTAGACGGCCTTAATATTCGAACTTCCTAATTTAGAGGCTGTCGCTATACC TTTTTTACCGGAAGTGTTTTCGATCTCAATCTTAGATGGATCGGAAGAAATCCAAGTTACAAGCTGAGTC AAATTTTGAGTAGATTTATCTGAAAAGATACCAGTCGCTTTAAATTGTTTTGTAAGACCGTGAGTGATAG AGTTAATCGTCGGTGTTATCTCGATAGAAGTAAGAAGTGCAGGAGTGACATTCAAAACGGAAGAGCCAGA TATGGAGTCTATCGTTGCTTTAATATTTGTATTTCCGGTAGCCACTGTTGTAACCGAACCTGTAACGTTG TTAACCATTGCTTTTCCGGGATTGGAAGAAGACCAGGTAGCTAGGGCAGTCACGTCTTGTACGGAATGAT CCGTATATGTTCCGGTGGCTTTAAATTGTCGTATTAGACCTTTTGCAACTGACGGATTTATAGGTGTTAC GGCAATGGAAATCAATTGTGCCGGAGTTACCTTTAAAATTACTTTAGAACTTTTGATTGAACCGAGGGCT GCGGATATTTCACTCGATCCTGGAGTGAGTGTATTTGTAATACCTTTACTTCCACTGGTATTTTTAATTT CAGCAATATCCGTATTAGAGGAATTCCAGGTAACTTGATTTGTAATATCGGAATTTGAGTTATCCGTAAA GATACCAGTAGCCTTGAATCTTTCTGTGAGTCCCTTTGCTTTGGAAGCAGCAGCCGGTGTGATTTGGATT TCAACAAGCTTTGCAGCTGTAACAGATAACGTAGAAACCGGACTACTTACCTTTCCGAATGTGGCTTTAA TATCCGTTGCTCCTGTAGCTGCTCCGTAAGCGTTTCCTTGATTTTTTTGGGCGTTTGAAATCGTCGCGAT TGAAGAATCGGATGAGAACCACGTAACAGCGGAAGTAATGTCCTTGTTAGAGTTGTCAGAGTAGATCCCA GTAGCCGTAAATTTTTGAGTTAACCCTTTTGCAAGAGAAGGATTTACAGGATTGATTTGAATAGAAGTGA GAACCGCAGGAACTACAGTAAACCAAGTGTTACCTGAAACTTTTCCTAAGGTTGCGGTAATAGTCGTGTT TCCAACTGAGTTGGTTTTTCCCAGACCTTTATTGTTGTCTAAGTTAGACACGCTTACGATTGCTGAAGAA GAATTCCAAGTGACTTGATCCGTAATATCCTTCTTAGAGTTATCCGTAAAAATCCCGATCGCAGTAAACT TTTGAGTTAGTCCTTTTGCAATGGAAGTGCGAGTTGGAGAGACTTCGATGGAAGTCAATGCAGCTTGTGT AACTTTAAAATCAGTGGATCCTTGTATTCCACCGATGGAAGCAGTGACTTTAACATTCCCTTGGTTGAGT GTGGAAGCTAATCCGTGGCTATCACTTGCATTGGAAATTGAGAGAATATCGGTATTAGAAGAATCCCAAG TAACTTGGTCGGTAATATCCGAGTTTGAATTATCTGTAAAGATCCCTGTAGCTTTAAAGTTTTCTTGTAA ACCTTTTGCAACTGTAGAATTTGTCGGAGAAACAGAAATAGAAACTAAGGCTGCTGGAGTAACGATTAGT TTTACGGATCCGATTATATTCTCGCTAGAAGCAGAAACAGTGACAATACCAGTATCAGCTGTTTCTAATA TTCCGTTGTTTTGAATATTAGCGATAGTGGAATTAGAAGAATTCCAAATAACAGAAGAGGAAATATCCCT GTTAGAGTTATCCGAATAGATTCCCGTAGCTGTTAGTTTTTGTTTTTTTCCGAGAGGAATATTCAGATCG TTTGAAGTTACTTGGATTTGAGAGAGAACAGCATCTCCAACGGTCATTTCTTCAGCCCCTTGTTTTGATT GAAAGGATGCACGAATATGAGCTGTTCCTAAATTGATCCCTGATGCCAACCCTGAATCATCTACTCGAAC CAAATCAGGATTACTGGAAGACCAAACGATCAGTGGTTCGTTGGAAATATCCTGATGAGAACCATCCGAA AAGATACCGATGGCTGAGAATTGACGATTAGTACCTTTAGGTAGTATACCTGACTCTAAACTCGTAACTT GAATTGAGTTAAGAATGGCTGGTGTAACGGTAATTTTTTGTTCAGAGTATAGGCCGTTGTATTCTGCTTT TATAATGGAAGAACCAGAAGCGATTCCTTTGACTCTGTTGCCTTCGATTGTTACAACGGATTGGGAATCG GGGACGATGGATGTCAAATCCGTAATATTCTGATTTGTTCCGTTATCAAAGATTGCGGTAACTTCTAGGG TTGTACTGGTACCGTTTGCGATAGAAGAATCTTGATAACTAAGTTCGATTCTTGTAATAGTCGGATTGAA GTTACCTAACAGAAGGTGGAAAAAGGACAGCCCATTACTTTTTTTACCAGCGGTTAATCCTACCAGACCG GTTAAAAGTGGCCAAGACATACAACTTTGAAAAAACATCGAAAGAAAAATCGAAATACAAAATATTTTCT TCA >YP_000448.1 hypothetical protein LIC10464 [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130] MKKIFCISIFLSMFFQSCMSWPLLTGLVGLTAGKKSNGLSFFHLLLGNFNPTITRIELSYQDSSIANGTS TTLEVTAIFDNGTNQNITDLTSIVPDSQSVVTIEGNRVKGIASGSSIIKAEYNGLYSEQKITVTPAILNS IQVTSLESGILPKGTNRQFSAIGIFSDGSHQDISNEPLIVWSSSNPDLVRVDDSGLASGINLGTAHIRAS FQSKQGAEEMTVGDAVLSQIQVTSNDLNIPLGKKQKLTATGIYSDNSNRDISSSVIWNSSNSTIANIQNN GILETADTGIVTVSASSENIIGSVKLIVTPAALVSISVSPTNSTVAKGLQENFKATGIFTDNSNSDITDQ VTWDSSNTDILSISNASDSHGLASTLNQGNVKVTASIGGIQGSTDFKVTQAALTSIEVSPTRTSIAKGLT QKFTAIGIFTDNSKKDITDQVTWNSSSAIVSVSNLDNNKGLGKTNSVGNTTITATLGKVSGNTWFTVVPA VLTSIQINPVNPSLAKGLTQKFTATGIYSDNSNKDITSAVTWFSSDSSIATISNAQKNQGNAYGAATGAT DIKATFGKVSSPVSTLSVTAAKLVEIQITPAAASKAKGLTERFKATGIFTDNSNSDITNQVTWNSSNTDI AEIKNTSGSKGITNTLTPGSSEISAALGSIKSSKVILKVTPAQLISIAVTPINPSVAKGLIRQFKATGTY TDHSVQDVTALATWSSSNPGKAMVNNVTGSVTTVATGNTNIKATIDSISGSSVLNVTPALLTSIEITPTI NSITHGLTKQFKATGIFSDKSTQNLTQLVTWISSDPSKIEIENTSGKKGIATASKLGSSNIKAVYKFIQS SPIPITVTDLKLKSITISPSSSSIAKGLTQQFKAIGTFIDGSEQEITNLVTWYSSKSDVAPINNAANAKG LATALSIGSSNISAIYNSISSNKINFNVSAATLDSIKINPVNNNIAKGLTQQYTALGVYSDSTIQDISDS VTWSSSNSDSISISNSTETKGKATALQIGNSKITATYNSISENIDITVSAATLSSISISPINTNINATVS KQFFAVGTYSDGTKADLTSSVTWSSSNKSQAKVSNASKTKGLVTGIASGNSIITATYGSVSGNTILTVNK TDTIAPTVQSVVSLSPTTIQVVYSESINNKEALDLSNYKIIDSSNFIGHCSDNTDFNSNSQTADFSLSSI KGSKNTFTITLSHSQILNKSYTLVVNKQGIHDLSSIPNSLSCPNNSDFIGKEQLKLTSAVCNSLNQVIVS FSKPLYSGKEATKSVECSNPSQCESRYKFAGVSSLGSITSVRILDGKVCGGAPADSSKICLTHSLLQSGG QYTIIAANDLNGDGFDNKSWGAIRDSFDQENLQSSPKDRINFIGCGNSPLNFMDGPIMSDPFGDGSDFGF LVDYNNQIYLGPNVKGNQAARFNYDGTFPESIFFSFTKDINADNRASSRDGGIPVPNYVTIGHTGCTLNS ADITTGCGPDNEDGRGVFAIGSLNKKSHIFIAGSRPRRFDYLYYSSDTDTNLNFKYIDMGEITGTATAGT SSIAVIDDRIHVGFAKKNKNLNAPDFGKITFNTSDQNRCAAGNNCDASDGYRGNRFRIDRMPYFGGLSVE DADNYETYTSDNSSINWGYYVGIDSLFVFKEKLYAANGGFPNSLHNGSIIHSTSANPSPCEGSNRCSSWK DTAPRSNPKWHNSPHNNWFSLELTKYRNLIPADKAFSQFAEFNGRLYVTRTICVTKEDHSGLRQSLQTVE GCTDGSYTNRRPQLWKCDPTLTGDTTTCEAEDWSLVGDNGTGFTNFGDNSNHSMTMMVASGSYLYIGFDN ENGIQIWRTNLENPGSSSHNWEPIGIGGLRDVTNRQIYSAISGMNFGVNFVYISVGNKNKPVKIYRQQNQ Protective antigen ompL1 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 2769678 45656861 LIC10973 AE016823 YP_000947 267671 I 1173341 1174303 - outer membrane protein 8.87 31373.06 320 contains porin activity; identified by sequence similarity; ORF located using Blastx/Glimmer >NC_005823.1:1173341-1174303 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130, chromosome I, complete sequence CTTAGAGTTCGTGTTTATAACCGAATCTGTAGATTTGCCCACCGACAACGATTGGATATGCAGGAAAAGG AGAAAGGTTCGTAGCTCCTCCTGCAGATTGAGTTTTACCAACTGCATACGCAGCAGACATGATCGTTTCT AATTCAAGAAAAACGTGTCCTTTATCGGTTACTCTGGCCTGAGTTCCAATTAAAAAGTTAGGAGCAATTC CAGAAGTTCTAAATCGAACGTGTTCACGAGTCGTGACTGGATCTGTTCCGTCTGCGATCAAGTTTGCAAC ACTTCCCGCTCCCGCTGCAGCTAAAATGTCATGACCTCCTTTGAGGTTGTTTGATCCGTTTAAACTCCAT CCACCATTGAAATAGTTTAAACCTGCTCCCATATATATTGCAGCGTCTTCAGTAACATTCAATTTGATAC CAACGGTTGCAGGAATGACGATAGAACTAAAACCCCAAGTCATATCTACAATGTTATAACCAGCGATGTC TGCTTTTGTAATACCGCCAGAAATTTTTTGAGTATATTCTGCAGCAACTCTCCAGAAAAAATATTTACCA AAGTCGGACTCATAACCTACCATCAAGTTTCCTCCGACCATGGCGCCTTTAGTGCTTCTTGCGTTGATCA AGCCGCCAGTAGTTCTATCGAGGGTAATCAATTTATTTTCAGCAGGAATCGCTTTTCTGGGAGCAACTCC TAGATAATTTCCTTCACCTGTAGGTTTTCCTGGATTTTGTACACAAGTAGGATCGTTTGGACCTACTGTA CAAGTATCTGTTGATCGGACCGGGCCATAATAACTTGCAGCGTCTAAACCATCTTTGGTGATGGTTCCTC CTAATTGTCCTAGGTCTAACTGTAACCCAAATCCTACAATTGCATATGTTTTTGCACTTAGGCTTGCAGC CGAAGATAATGCTACGGCTAAAATGAGCAATGCCTTACTTATGTTACGGATCA >YP_000947.1 outer membrane protein [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130] MIRNISKALLILAVALSSAASLSAKTYAIVGFGLQLDLGQLGGTITKDGLDAASYYGPVRSTDTCTVGPN DPTCVQNPGKPTGEGNYLGVAPRKAIPAENKLITLDRTTGGLINARSTKGAMVGGNLMVGYESDFGKYFF WRVAAEYTQKISGGITKADIAGYNIVDMTWGFSSIVIPATVGIKLNVTEDAAIYMGAGLNYFNGGWSLNG SNNLKGGHDILAAAGAGSVANLIADGTDPVTTREHVRFRTSGIAPNFLIGTQARVTDKGHVFLELETIMS AAYAVGKTQSAGGATNLSPFPAYPIVVGGQIYRFGYKHEL Protective antigen Atzingen et al., 2012 journal Atzingen MV, Vieira ML, Oliveira R, Domingos RF, Mendes RS, Barros AT, Gonçales AP, de Morais ZM, Vasconcellos SA, Nascimento AL 2012 6 79-87 The open microbiology journal Conrad et al., 2017 journal Conrad NL, Cruz McBride FW, Souza JD, Silveira MM, Félix S, Mendonça KS, Santos CS, Athanazio DA, Medeiros MA, Reis MG, Dellagostin OA, McBride AJ 2017 11 3 e0005441 PLoS neglected tropical diseases Evangelista et al., 2017 journal Evangelista KV, Lourdault K, Matsunaga J, Haake DA 2017 12 7 e0180004 PloS one Fernandes et al., 2017 journal Fernandes LGV, Teixeira AF, Filho AFS, Souza GO, Vasconcellos SA, Heinemann MB, Romero EC, Nascimento ALTO 2017 57 61-69 International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Forster et al., 2013 journal Forster KM, Hartwig DD, Seixas FK, Bacelo KL, Amaral M, Hartleben CP, Dellagostin OA 2013 20 5 725-731 Clinical and vaccine immunology : CVI Humphryes et al., 2014 journal Humphryes PC, Weeks ME, AbuOun M, Thomson G, Núñez A, Coldham NG 2014 21 4 546-551 Clinical and vaccine immunology : CVI Lin et al., 2016 journal Lin X, Xiao G, Luo D, Kong L, Chen X, Sun D, Yan J 2016 16 1 241 BMC microbiology Maneewatch et al., 2007 journal Maneewatch S, Tapchaisri P, Sakolvaree Y, Klaysing B, Tongtawe P, Chaisri U, Songserm T, Wongratanacheewin S, Srimanote P, Chongsa-nguanz M, Chaicumpa W 2007 25 1 75-82 Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand Umthong et al., 2015 journal Umthong S, Buaklin A, Jacquet A, Sangjun N, Kerdkaew R, Patarakul K, Palaga T 2015 25 4 526-536 Journal of microbiology and biotechnology Vijayachari et al., 2015 journal Vijayachari P, Vedhagiri K, Mallilankaraman K, Mathur PP, Sardesai NY, Weiner DB, Ugen KE, Muthumani K 2015 11 8 1945-1953 Human vaccines & immunotherapeutics Wiki: Leptospirosis website http://en.wikipedia.org/wiki/Leptospirosis