Mannheimia haemolytica 75985 Bovine Respiratory Disease Mannheimia haemolytica is the principal bacterium isolated from respiratory disease in feedlot cattle and is a significant component of enzootic pneumonia in all neonatal calves. A commensal of the nasopharynx, M. haemolytica is an opportunist, gaining access to the lungs when host defenses are compromised by stress or infection with respiratory viruses or mycoplasma (Rice et al., 2007). Baboon Papio cynocephalus 9556 Bank vole Clethrionomys glareolus 447135 Bear Ursus americanus 9643 Birds Passeroidea 175121 Brown Trout Salmo trutta 8032 Buffalo Bison bison 9901 Carnivores Vulpes 9625 Cat Felis catus 9685 Catfishes Siluriformes 7995 Cattle Bos taurus 9913 Chicken Gallus gallus 9031 Chimpanzee Pan troglodytes 9598 chinchillas Chinchillidae 10150 Copper Pheasant Syrmaticus soemmerringii 9067 Deer Cervus elaphus 9860 Deer mouse Peromyscus maniculatus 10042 Dog Canis familiaris 9615 Ducks Anas 8835 Ferret Mustela putorius furo 9669 Fish Hyperotreti 117565 Gerbil Gerbillina 10045 Goat Capra hircus 9925 Gray wolf Canis lupus 9612 Guinea pig Cavia porcellus 10141 Hamster Mesocricetus auratus 10036 Horse Equus caballus 9796 Human Homo sapiens 9606 Macaque Macaca fascicularis 9541 Mongolian Gerbil Meriones unguiculatus 10047 Monkey Platyrrhini 9479 Mouse Mus musculus 10090 None None Parrot Psittacidae 9224 Pig Sus scrofa 9823 Rabbit Oryctolagus cuniculus 9986 Rainbow trout Oncorhynchus mykiss 8022 Rat Rattus 10114 Raven Corvus corax 56781 sei whale Balaenoptera borealis 9768 Sheep Ovis aries 9940 Squirrel Spermophilus richardsonii 37591 Tree shrew Tupaiidae 9393 Trouts, salmons & chars Salmoninae 504568 Turkey Meleagris gallopavo 9103 Vole Microtus ochrogaster 79684 Water buffalo Bubalus bubalis 391902 Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45H5.20) Texas Vet Lab, Inc. VO_0001877 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45H5.21) Texas Vet Lab, Inc. VO_0001878 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida-Salmonella Typhimurium Bacterin-Toxoid (USDA: 4109.20) Texas Vet Lab, Inc. VO_0001879 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Parainfluenza 3 Killed Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin (USDA: 4265.00) Boehringer Ingelheim Vetmedica, Inc. VO_0001885 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 43S5.20) Texas Vet Lab, Inc. VO_0001905 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida-Salmonella Typhimurium Bacterin-Toxoid (USDA: 43T5.20) Texas Vet Lab, Inc. VO_0001906 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Mannheimia Haemolytica Bacterin (USDA: 44A5.20) Wyeth VO_0001938 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica Bacterin (USDA: 4477.20) Wyeth VO_0001961 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica Toxoid (USDA: 4X49.20) Wyeth VO_0002004 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica Toxoid (USDA: 4X49.21) Wyeth VO_0002005 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45B9.20) Boehringer Ingelheim Vetmedica, Inc. VO_0002006 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 45B9.21) Boehringer Ingelheim Vetmedica, Inc. VO_0002007 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus-Mannheimia Haemolytica-Pasteurella Multocida Modified Live Virus, Avirulent Live Culture Vaccine (USDA: 11A8.22) Intervet Inc. VO_0002008 Live vaccine Licensed USA Bovine Virus Diarrhea Killed Virus Vaccine-Haemophilus Somnus-Mannheimia Haemolytica-Pasteurella Multocida Bacterin-Toxoid (USDA: 4C95.20) Texas Vet Lab, Inc. VO_0002024 Inactivated or "killed" vaccine Licensed USA Mannheimia haemolytica aroA mutant vaccine VO_0002856 Live, attenuated vaccine Research Intraperitoneal injection (i.p.) Intraperitoneal injection (i.p.) Gene mutation This aroA mutant is from Mannheimia haemolytica (Homchampa et al., 1994). An aroA mutant is attenuated in mice (Homchampa et al., 1994). An aroA mutant induced significant protection in mice from challenge with wild type M. haemolytica (Homchampa et al., 1994). Mannheimia Haemolytica-Pasteurella Multocida Avirulent Live Culture Vaccine (USDA: 1861.01) Intervet Inc. VO_0002029 Live vaccine Licensed USA aroA M. haemolytica NADC-D60 451485 CDD:179423 CDD:30129 75985 ? 5-enolpyruvylshikimate 3-phosphate synthase 434 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional >gi|451485|gb|AAA21529.1| 5-enolpyruvylshikimate 3-phosphate synthase [Mannheimia haemolytica] MEKLTLTPISRVEGEINLPGSKSLSNRALLLAALATGTTQVTNLLDSDDIRHMLNALKALGVKYELSDDK TVCVLEGIGGAFKVQNGLSLFLGNAGTAMRPLAAALCLKGEEKSQIILTGEPRMKERPIKHLVDALRQVG AEVQYLENEGYPPLAISNSVCRGGKVQIDGSISSQFLTALLMSAPLAEGDMEIEIIGDLVSKPYIDITLS MMNDFGITVENRDYKTFLVKGKQGYVAPQGNYLVEGDASSASYFLASGAIKAGKVTGIGKKSIQGDRLFA DVLEKMGAKITWGEDFIQAEQSPLKGVDMDMNHIPDAAMTIATTALFAEGETVIRNIYNWRVKETDRLTA MATELRKVGAEVEEGEEGEDFIRIQPLALENFQHAEIETYNDHRMAMCFSLIALSNTEVTILDPNCTAKT FPTYFRDLEKLSVR Virmugen An aroA mutant is highly attenuated in mice and induced significant protection after two doses from challenge with wild type M. haemolytica [Ref1773:Homchampa et al., 1994]. Homchampa et al., 1994 journal Homchampa P, Strugnell RA, Adler B 1994 42 1 35-44 Veterinary microbiology Rice et al., 2007 journal Rice JA, Carrasco-Medina L, Hodgins DC, Shewen PE 2007 8 2 117-128 Animal health research reviews / Conference of Research Workers in Animal Diseases