Infectious Bursal Disease Virus (IBDV)
10995
The virus is attracted to lymphoid cells and especially those of B-lyphocyte origins. Young birds at around two to eight weeks of age that have highly active bursa of Fabricius are more susceptible to disease. Birds over eight weeks are resistant to challenge and will not show clinical signs unless infected by highly virulent strains.
After ingestion, the virus destroys the lymphoid follicles in the bursa of Fabricius as well as the circulating B-cells in the secondary lymphoid tissues such as GALT (gut-associated lymphoid tissue), CALT (conjunctiva), BALT (Bronchial) cecal tonsils, Harderian gland, etc. Acute disease and death is due to the necrotizing effect of these viruses on the host tissue. If the bird survives and recovers from this phase of the disease, they remain immunocompromised which means they are more susceptible to other diseases and vaccination in the face of outbreak will not be effective (Wiki: Infectious Bursal Disease).
Infectious Bursal Disease
Passive immunity protects against disease, as does previous infection with avirulent strains. In broiler farms, breeder flocks are immunized against IBD so that they would confer protective antibodies to their progenies which would be slaughtered for consumption before their passive immunity wears out (Wiki: Infectious Bursal Disease).
Chickens
Infectious bursal disease (IBD) is a highly contagious disease of young chickens caused by infectious bursal disease virus (IBDV), characterized by immunosuppression and mortality generally at 3 to 6 weeks of age. It is economically important to the poultry industry worldwide due to increased susceptibility to other diseases and negative interference with effective vaccination. In recent years, very virulent strains of IBDV (vvIBDV), causing severe mortality in chicken, have emerged in Europe, Latin America, South-East Asia, Africa and the Middle East.
Baboon
Papio cynocephalus
9556
Bank vole
Clethrionomys glareolus
447135
Bear
Ursus americanus
9643
Birds
Passeroidea
175121
Brown Trout
Salmo trutta
8032
Buffalo
Bison bison
9901
Carnivores
Vulpes
9625
Cat
Felis catus
9685
Catfishes
Siluriformes
7995
Cattle
Bos taurus
9913
Chicken
Gallus gallus
9031
Chimpanzee
Pan troglodytes
9598
chinchillas
Chinchillidae
10150
Copper Pheasant
Syrmaticus soemmerringii
9067
Deer
Cervus elaphus
9860
Deer mouse
Peromyscus maniculatus
10042
Dog
Canis familiaris
9615
Ducks
Anas
8835
Ferret
Mustela putorius furo
9669
Fish
Hyperotreti
117565
Gerbil
Gerbillina
10045
Goat
Capra hircus
9925
Gray wolf
Canis lupus
9612
Guinea pig
Cavia porcellus
10141
Hamster
Mesocricetus auratus
10036
Horse
Equus caballus
9796
Human
Homo sapiens
9606
Macaque
Macaca fascicularis
9541
Mongolian Gerbil
Meriones unguiculatus
10047
Monkey
Platyrrhini
9479
Mouse
Mus musculus
10090
None
None
Parrot
Psittacidae
9224
Pig
Sus scrofa
9823
Rabbit
Oryctolagus cuniculus
9986
Rainbow trout
Oncorhynchus mykiss
8022
Rat
Rattus
10114
Raven
Corvus corax
56781
sei whale
Balaenoptera borealis
9768
Sheep
Ovis aries
9940
Squirrel
Spermophilus richardsonii
37591
Tree shrew
Tupaiidae
9393
Trouts, salmons & chars
Salmoninae
504568
Turkey
Meleagris gallopavo
9103
Vole
Microtus ochrogaster
79684
Water buffalo
Bubalus bubalis
391902
Bursal Disease Killed Virus Vaccine (USDA: 1275.00)
Wyeth
VO_0001632
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease Killed Virus Vaccine (USDA: 1275.02)
Lohmann Animal Health International
VO_0001633
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease Killed Virus Vaccine (USDA: 1275.20)
Intervet Inc.
VO_0001634
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.00)
Wyeth, Intervet Inc., Lohmann Animal Health International, Merial, Inc.
VO_0001635
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.01)
Biomune Company
VO_0001636
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.02)
Lohmann Animal Health International
VO_0001637
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.04)
Biomune Company
VO_0001638
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.0A)
Merial, Inc.
VO_0001639
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.10)
Wyeth, Merial, Inc.
VO_0001640
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.11)
Intervet Inc., Lohmann Animal Health International
VO_0001641
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.12)
Intervet Inc., Merial, Inc.
VO_0001642
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.13)
Merial, Inc.
VO_0001643
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.16)
Intervet Inc.
VO_0001644
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.17)
Intervet Inc.
VO_0001645
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.18)
Intervet Inc.
VO_0001646
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.19)
Intervet Inc.
VO_0001647
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.40)
Intervet Inc.
VO_0001648
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1271.41)
Intervet Inc.
VO_0001649
Live vaccine
Licensed
USA
Bursal Disease Live Virus Vaccine (USDA: 1272.00)
Lohmann Animal Health International
VO_0001650
Live vaccine
Licensed
USA
Bursal Disease Modified Live VirusVaccine (USDA: 1271.15)
Wyeth
VO_0001651
Live, attenuated vaccine
Licensed
USA
Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.01)
Lohmann Animal Health International
VO_0001652
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.40)
Merial, Inc., Biomune Company
VO_0001653
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.41)
Intervet Inc., Biomune Company
VO_0001654
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.4A)
Lohmann Animal Health International
VO_0001655
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease Standard & Variant, Live Virus Vaccine (USDA: 12B1.00)
Intervet Inc., Merial, Inc.
VO_0001656
Live vaccine
Licensed
USA
Bursal Disease Standard & Variant, Live Virus Vaccine (USDA: 12B1.01)
Merial, Inc.
VO_0001657
Live vaccine
Licensed
USA
Bursal Disease Variant, Killed Virus Vaccine (USDA: 12A5.00)
Intervet Inc.
VO_0001658
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease Variant, Live Virus Vaccine (USDA: 12L1.00)
Intervet Inc.
VO_0001659
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotype 3, Live Marek's Disease Vector Vaccine (USDA: 1A88.R0)
Merial, Inc., Biomune Company
VO_0002197
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1288.42)
Merial, Inc.
VO_0002043
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1288.4A)
Merial, Inc.
VO_0002047
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1A82.50)
Wyeth
VO_0002196
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotypes 1 & 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1281.R0)
Biomune Company
VO_0002040
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotypes 1 & 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1281.R0)
Biomune Company
VO_0002040
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotypes 1 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1281.R1)
Biomune Company
VO_0002041
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.43)
Merial, Inc.
VO_0002044
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.44)
Merial, Inc.
VO_0002045
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1288.45)
Merial, Inc.
VO_0002046
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1B82.50)
Wyeth
VO_0002200
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1A88.R1)
Biomune Company
VO_0002198
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Serotypes 2 & 3, Live Virus, Live Marek's Disease Vector Vaccine (USDA: 1A88.R2)
Merial, Inc.
VO_0002199
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Standard & Variant, Serotype 3, Live Virus Vaccine (USDA: 12C8.40)
Merial, Inc.
VO_0002051
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Standard & Variant, Serotype 3, Live Virus Vaccine (USDA: 12C8.43)
Merial, Inc.
VO_0002053
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Standard & Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C8.42)
Merial, Inc.
VO_0002052
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Standard & Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C8.44)
Merial, Inc.
VO_0002054
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Variant Strain, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.52)
Intervet Inc.
VO_0002050
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Variant, Serotype 3, Live Virus Vaccine (USDA: 1282.50)
Intervet Inc.
VO_0002042
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: )
Intervet Inc.
VO_0002031
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.50)
Intervet Inc.
VO_0002048
Live vaccine
Licensed
USA
Bursal Disease-Marek's Disease Variant, Serotypes 2 & 3, Live Virus Vaccine (USDA: 12C2.51)
Intervet Inc.
VO_0002049
Live vaccine
Licensed
USA
Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.10)
Wyeth
VO_0002065
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.11)
Intervet Inc.
VO_0002066
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease Killed Virus Vaccine (USDA: 12G5.43)
Lohmann Animal Health International, Biomune Company
VO_0002068
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease Standard & Variant, Killed Virus Vaccine (USDA: 12G5.42)
Intervet Inc., Biomune Company
VO_0002067
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 12H1.4M)
Merial, Inc.
VO_0002069
Live vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis B1 Type, B1 Strain, Mass & Ark Types, Live Virus Vaccine (USDA: 12H1.67)
Merial, Inc.
VO_0002070
Live vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.40)
Wyeth
VO_0002071
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.43)
Lohmann Animal Health International
VO_0002072
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis Mass Type, Killed Virus Vaccine (USDA: 12J5.62)
Biomune Company
VO_0002074
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12D5.45)
Lohmann Animal Health International, Merial, Inc.
VO_0002060
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12J5.61)
Intervet Inc., Biomune Company
VO_0002073
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.00)
Lohmann Animal Health International, Biomune Company
VO_0002075
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.01)
Intervet Inc., Lohmann Animal Health International, Biomune Company
VO_0002076
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Killed Virus Vaccine (USDA: 12M5.40)
Wyeth
VO_0002078
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.11)
Intervet Inc.
VO_0002077
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.43)
Lohmann Animal Health International
VO_0002081
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.50)
Biomune Company
VO_0002082
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.90)
Wyeth, Lohmann Animal Health International
VO_0002083
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Mass Type, Killed Virus Vaccine (USDA: 12M5.91)
Wyeth, Lohmann Animal Health International
VO_0002084
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12M5.41)
Lohmann Animal Health International, Merial, Inc.
VO_0002079
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass & Ark Types, Killed Virus Vaccine (USDA: 12M5.42)
Lohmann Animal Health International
VO_0002080
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Bronchitis-Reovirus Standard & Variant, Mass Type, Killed Virus Vaccine (USDA: 12M5.E0)
Biomune Company
VO_0002085
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.40)
Merial, Inc.
VO_0002086
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.41)
Intervet Inc., Biomune Company
VO_0002087
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Newcastle Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12P5.E0)
Biomune Company
VO_0002088
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Reovirus Killed Virus Vaccine (USDA: 12D5.02)
Biomune Company
VO_0002056
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.01)
Merial, Inc., Biomune Company
VO_0002055
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.03)
Lohmann Animal Health International
VO_0002057
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.04)
Lohmann Animal Health International
VO_0002058
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.30)
Intervet Inc.
VO_0002059
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.E0)
Biomune Company
VO_0002061
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.F0)
Intervet Inc.
VO_0002062
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.F1)
Intervet Inc.
VO_0002063
Inactivated or "killed" vaccine
Licensed
USA
Bursal Disease-Reovirus Standard & Variant, Killed Virus Vaccine (USDA: 12D5.T0)
Wyeth
VO_0002064
Inactivated or "killed" vaccine
Licensed
USA
BV-Dual-S1
VO_0004652
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
fp-IBD1
VO_0004622
Recombinant vector vaccine
Licensed
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
FP-IBDV-VP2
VO_0004742
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
(Butter et al., 2013) fp-IBD1, which consists of a fowlpox virus vector carrying the VP2 gene of infectious bursal disease virus (IBDV) fused with β-galactosidase.
Intramuscular injection (i.m.)
Recombinant vector construction
A fowlpox virus vector was used to carry the VP2 gene of infectious bursal disease virus (IBDV) fused with β-galactosidase (Butter et al., 2013).
IBDV DNA vaccine pCAGoptiVP2/rVP2
VO_0004533
DNA vaccine
Research
pCAGGS prime, rVP2 protein boost [Ref2651:Gao et al., 2013]
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
DNA vaccine construction
The synthetic gene for VP2 protein of vvIBDV Gx with codons optimized for chicken usage was synthesized and cloned into pCAGGS vector (Gao et al., 2013).
Chickens in the DNA prime–protein boost group developed significantly higher levels of ELISA and neutralizing antibodies to IBDV compared with those immunized with either the DNA vaccine or the protein vaccine alone (P < 0.05). Furthermore, the highest levels of lymphocyte proliferation response, IL-4 and IFN-γ production were induced following priming with the DNA vaccine and boosting with the rVP2 protein (Gao et al., 2013).
Chickens inoculated with the DNA prime–protein boost vaccine had 100% protection against challenge with vvIBDV, as evidenced by the absence of clinical signs, mortality, and bursal atrophy. In contrast, chickens receiving the DNA vaccine and the rVP2 protein vaccine had 67% and 80% protection, respectively (Gao et al., 2013).
IBDV DNA vaccine pCAGVP243-IL-18
VO_0004534
DNA vaccine
Research
pCAGGS [Ref2652:Li et al., 2013]
Intramuscular injection (i.m.)
IL-18 (Li et al., 2013)
Intramuscular injection (i.m.)
VP243 gene of vvIBDV HLJ0504 (VP243 can be cleaved into VP2, VP3, and VP4) (Li et al., 2013)
DNA vaccine construction
Chickens immunized with plasmid pCAGVP243-IL-18 carrying both VP243 and IL-18 genes induced significantly higher levels of antibodies, lymphocyte proliferation responses and of the cytokines IL-4 and IFN-γ than those injected with pCAGVP243 encoding the VP243 gene alone (Li et al., 2013).
Furthermore, pCAGVP243-IL-18 provided higher protection (93%) against vvIBDV challenge in chickens than pCAGVP243 (60%), as evidenced by the absence of clinical signs, mortality, and bursal atrophy (Li et al., 2013).
Infectious Bursal Disease Virus DNA Vaccine expressing VP2
VO_0004585
DNA vaccine
Research
pIRES [Ref2718:Kumar et al., 2009]
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
DNA vaccine construction
Birds immunized with pibdVP2-IRES-chiIL-2 plasmid at 21 days post-challenge showed the highest antibody titer. In addition, blood analysis showed a proliferation of CD4-positive cells in the group vaccinated with pibdVP2-IRES-chiIL-2 (Kumar et al., 2009).
The birds were immunized intramuscularly with 50 μg plasmid DNA in the quadricep muscle of the hind limb (Kumar et al., 2009).
VO_0003057
Birds vaccinated with the pibdVP2-IRES-chiIL-2 plasmid showed an 80% protection efficacy (Kumar et al., 2009).
All vaccinated birds and the unvaccinated control birds were challenged with 10^5 ELD50 (50% embryo lethal dose) virulent IBDV (strain KT1/99) through the intrabursal and intraocular routes at 21 days post-immunization (Kumar et al., 2009).
rFPV-IBDV-VP 2.4.3
VO_0004750
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
Recombinant FPV-VP 2.4.3 contained the gene for the VP 2-VP4-VP3 polyprotein under the control of the vaccinia virus late promoter P.L 11 inserted within the thymidine kinase (TK) gene of FPV (Heine and Boyle, 1993).
Intramuscular injection (i.m.)
Recombinant vector construction
Recombinant FPV-VP 2.4.3 contained the gene for the VP 2-VP4-VP3 polyprotein under the control of the vaccinia virus late promoter P.L 11 inserted within the thymidine kinase (TK) gene of FPV (Heine and Boyle, 1993).
Vaccination with FPV-VP2 (Heine and Boyle, 1993).
VO_0003057
A significant level of protection was provided by FPV-VP2 vaccination, although the level was lower than the protection provided by an oil adjuvanted inactivated whole IBDV vaccine. Birds vaccinated with FPV-VP2.4.3 were not protected from infection as assessed by ELISA for the presence of IBD virus in bursae (Heine and Boyle, 1993).
The birds were challenged with IBDV (strain 002-73) (Heine and Boyle, 1993).
rFPV-IBDV-VP2
VO_0004625
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
Marek's disease and Fowlpox viruses expressing the vvIBDV host-protective antigen VP2 (rMDV, rFPV) (Tsukamoto et al., 2000).
Intramuscular injection (i.m.)
Recombinant vector construction
Marek's disease and Fowlpox viruses expressing the vvIBDV host-protective antigen VP2 (rMDV, rFPV) (Tsukamoto et al., 2000).
Chickens vaccinated with the rFPV or rMDV alone, or vaccinated simultaneously with both at their hatch (rMDV-rFPV(1d)) (Tsukamoto et al., 2000).
VO_0003057
Most chickens were protected against developing clinical signs and mortality; however, only zero to 14% of the chickens were protected against gross lesions (Tsukamoto et al., 2000).
rMDV-IBDV-VP2
VO_0004749
Recombinant vector vaccine
Research
Intramuscular injection (i.m.)
Marek's disease and Fowlpox viruses expressing the vvIBDV host-protective antigen VP2 (rMDV, rFPV) (Tsukamoto et al., 2000).
Intramuscular injection (i.m.)
Recombinant vector construction
IBDV host-protective antigen VP2 was expressed in a recombinant vaccine vector (Tsukamoto et al., 2000).
Chickens vaccinated with the rFPV or rMDV alone, or vaccinated simultaneously with both at their hatch (rMDV-rFPV(1d)) (Tsukamoto et al., 2000).
VO_0003057
Most chickens were protected against developing clinical signs and mortality; however, only zero to 14% of the chickens were protected against gross lesions (Tsukamoto et al., 2000).
VP2
Infectious bursal disease virus strain GX
32482035
CDD:280020
10995
?
VP2
4.01
14476.16
208
type: vvIBDV
>AAP84370.1 VP2, partial [Infectious bursal disease virus]
YTITAADDYQFSSQYQAGGVTITLFSANIDAITSLSIGGELVFQTSVQGLILGATIYLIGFDGTAVITRA
VAADNGLTAGTDNLMPFNIVIPTSEITQPITSIKLEIVTSKSGGQAGDQMSWSASGSLAVTIHGGNYPGA
LRPVT
Protective antigen
VP2-VP4-VP3
Infectious bursal disease virus strain 3529/92 serotype 1
452029936
CDD:280020
CDD:280022
CDD:280021
10995
?
polyprotein
5.6
102895.25
1086
subtype: vvIBDV
>AGF91988.1 polyprotein [Infectious bursal disease virus]
MTNLQDQTQQIVPFIRSLLMPTTGPASIPDDTLEKHTLRSETSTYNLTVGDTGSGLIVFFPGFPGSIVGA
HYTLQSNGNYKFDQMLLTAQNLPASYNYCRLVSRSLTVRSSTLPGGVYALNGTINAVTFQGSLSELTDVS
YNGLMSATANINDKIGNVLVGEGVTVLSLPTSYDLGYVRLGDPIPAIGLDPKMVATCDSSDRPRVYTITA
ADDYQFSSQYQAGGVTITLFSANIDAITSLSIGGELVFQTSVQGLILGATIYLIGFDGTAVITRAVAADN
GLTAGTDNLMPFNIVIPTSEITQPITSIKLEIVTSKSGGQAGDQMSWSASGSLAVTIHGGNYPGALRPVT
LVAYERVATGSVVTVAGVSNFELIPNPELAKNLVTEYGRFDPGAMNYTKLILSERDRLGIKTVWPTREYT
DFREYFMEVADLNSPLKIAGAFGFKDIIRALRRIAVPVVSTLFPPAAPLAHAIGEGVDYLLGDEAQAASG
TARAASGKARAASGRIRQLTLAADKGYEVVANLFQVPQNPVVDGILASPGILRGAHNLDCVLREGATLFP
VVITTVEDAMTPKALNSKMFAVIEGVREDLQPPSQRGSFIRTLSGHRVYGYAPDGVLPLETGRDYTVVPI
DDVWDDSIMLSNDPIPPIVGNSGNLAIAYMDVFRPKVPIHVAMTGALNAYGEIENVSFRSTKLATAHRLG
LKLAGPGAFDVNTGSNWATFIKRFPHNPRDWDRLPYLNLPYLPPNAGRQYDLAMAASEFKETPELESAVR
AMEAAANVDPLFQSALSVFMWLEENGIVTDMANFALSDPNAHRMRNFLANAPQAGSKSQRAKYGTAGYGV
EARGPTPEEAQREKDTRISKKMETMGIYFATPEWVALNGHRGPSPGQLKYWQNTREIPDPNEDYLDYVHA
EKSRLASEEQILRAATSIYGAPGQAEPPQAFIDEVAKVYEINHGRGPNQEQMKDLLLTAMEMKHRNPRRA
PPKPKPKPNVPTQRPPGRLGRWIRAVSDEDLE
Protective antigen
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journal
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3-4
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2009
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Vaccine
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journal
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Vaccine
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journal
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website
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http://en.wikipedia.org/wiki/Infectious_bursal_disease
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journal
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BacMam virus-based surface display of the infectious bronchitis virus (IBV) S1 glycoprotein confers strong protection against virulent IBV challenge in chickens
2014
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6
664-670
Vaccine