Bovine Respiratory Syncytial Virus
11246
Respiratory Disease
Cattle
Bovine respiratory syncytial virus (BRSV) is an RNA virus classified as a pneumovirus in the paramyxovirus family. This virus was named for its characteristic cytopathic effect—the formation of syncytial cells. In additional to cattle, sheep and goats can also be infected by respiratory syncytial viruses. Human respiratory syncytial virus (HRSV) is an important respiratory pathogen in infants and young children. Antigenic subtypes are known to exist for HRSV, and preliminary evidence suggests that there may be antigenic subtypes of BRSV. BRSV is distributed worldwide, and the virus is indigenous in the cattle population.
BRSV infections associated with respiratory disease occur predominantly in young beef and dairy cattle. Passively derived immunity does not appear to prevent BRSV infections but will reduce the severity of disease. Initial exposures to the virus are associated with severe respiratory disease; subsequent exposures result in mild to subclinical disease. BRSV is an important virus in the bovine respiratory disease complex because of its frequency of occurrence, predilection for the lower respiratory tract, and ability to predispose the respiratory tract to secondary bacterial infection. In outbreaks, morbidity tends to be high, and the case fatality rate can be 0-20% (Merck Vet Manual: BRSV).
Baboon
Papio cynocephalus
9556
Bank vole
Clethrionomys glareolus
447135
Bear
Ursus americanus
9643
Birds
Passeroidea
175121
Brown Trout
Salmo trutta
8032
Buffalo
Bison bison
9901
Carnivores
Vulpes
9625
Cat
Felis catus
9685
Catfishes
Siluriformes
7995
Cattle
Bos taurus
9913
Chicken
Gallus gallus
9031
Chimpanzee
Pan troglodytes
9598
chinchillas
Chinchillidae
10150
Copper Pheasant
Syrmaticus soemmerringii
9067
Deer
Cervus elaphus
9860
Deer mouse
Peromyscus maniculatus
10042
Dog
Canis familiaris
9615
Ducks
Anas
8835
Ferret
Mustela putorius furo
9669
Fish
Hyperotreti
117565
Gerbil
Gerbillina
10045
Goat
Capra hircus
9925
Gray wolf
Canis lupus
9612
Guinea pig
Cavia porcellus
10141
Hamster
Mesocricetus auratus
10036
Horse
Equus caballus
9796
Human
Homo sapiens
9606
Macaque
Macaca fascicularis
9541
Mongolian Gerbil
Meriones unguiculatus
10047
Monkey
Platyrrhini
9479
Mouse
Mus musculus
10090
None
None
Parrot
Psittacidae
9224
Pig
Sus scrofa
9823
Rabbit
Oryctolagus cuniculus
9986
Rainbow trout
Oncorhynchus mykiss
8022
Rat
Rattus
10114
Raven
Corvus corax
56781
sei whale
Balaenoptera borealis
9768
Sheep
Ovis aries
9940
Squirrel
Spermophilus richardsonii
37591
Tree shrew
Tupaiidae
9393
Trouts, salmons & chars
Salmoninae
504568
Turkey
Meleagris gallopavo
9103
Vole
Microtus ochrogaster
79684
Water buffalo
Bubalus bubalis
391902
Bovine Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1161.00)
Heska Corporation
VO_0001875
Live, attenuated vaccine
Licensed
USA
Bovine Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1161.20)
Heska Corporation
VO_0001876
Live, attenuated vaccine
Licensed
USA
Bovine respiratory syncytial virus glycoprotein G mutant vaccine
VO_0002951
Live, attenuated vaccine
Research
intranasal immunization
intranasal immunization
Gene mutation
This glycoprotein G mutant is from Bovine respiratory syncytial virus (Schmidt et al., 2002).
A glycoprotein G mutant is attenuated in calves (Schmidt et al., 2002).
A glycoprotein G mutant induces significant protection in calves from challenge with wild type BRSV (Schmidt et al., 2002).
Bovine Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1095.20)
Boehringer Ingelheim Vetmedica, Inc., Merial, Inc.
VO_0001558
Inactivated or "killed" vaccine
Licensed
USA
Bovine Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1095.21)
Boehringer Ingelheim Vetmedica, Inc.
VO_0001559
Inactivated or "killed" vaccine
Licensed
USA
Bovine Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 40A5.20)
Boehringer Ingelheim Vetmedica, Inc.
VO_0002205
Inactivated or "killed" vaccine
Licensed
USA
Bovine Respiratory Syncytial Virus recombinant vector vaccine BHVl/BRSVG encoding the G protein
VO_0004289
Recombinant vector vaccine
Licensed
BHVI [Ref2118:Schrijver et al., 1997]
intranasal immunization
intranasal immunization
Recombinant vector construction
The gE gene was replaced by a gene encoding the G protein of BRSV in a BHVI vector (Schrijver et al., 1997).
VO_0000286
Flow cytometric analysis showed a significant relative increase of gamma/delta+ T cells in peripheral blood after BRSV challenge-infection of the calves of the control group but not in the vaccinated groups. These results indicate that the G protein of BRSV can induce significant protection against BRSV infection in cattle, and that the BHV1/BRSV-G vaccine protects effectively against a subsequent BRSV and BHV1 infection (Schrijver et al., 1997).
Bovine Respiratory Syncytial Virus Vaccine Modified Live Virus (USDA: 1091.20)
Pfizer, Inc., Heska Corporation
VO_0001560
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.00)
Heska Corporation
VO_0001895
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.20)
Wyeth, Pfizer, Inc., Heska Corporation, Texas Vet Lab, Inc.
VO_0001896
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.21)
Pfizer, Inc.
VO_0001897
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.22)
Pfizer, Inc.
VO_0001898
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.23)
Pfizer, Inc.
VO_0001899
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11B5.20)
Merial, Inc.
VO_0001900
Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.00)
Wyeth
VO_0001939
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.20)
Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., Heska Corporation, Novartis Animal Health US, Inc.
VO_0001940
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.21)
Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.
VO_0001941
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.22)
Wyeth, Intervet Inc., Pfizer, Inc.
VO_0001942
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.23)
Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.
VO_0001943
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.24)
Boehringer Ingelheim Vetmedica, Inc.
VO_0001944
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.25)
Pfizer, Inc.
VO_0001945
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.26)
Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.
VO_0001946
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.28)
Pfizer, Inc.
VO_0001947
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.30)
Intervet Inc., Heska Corporation
VO_0001948
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.20)
Boehringer Ingelheim Vetmedica, Inc., Merial, Inc., Novartis Animal Health US, Inc.
VO_0001949
Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.22)
Wyeth
VO_0001950
Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.20)
Novartis Animal Health US, Inc.
VO_0001951
Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.22)
Novartis Animal Health US, Inc.
VO_0001952
Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B5.20)
Novartis Animal Health US, Inc.
VO_0001953
Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.20)
Novartis Animal Health US, Inc.
VO_0001954
Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.21)
Novartis Animal Health US, Inc.
VO_0001955
Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.20)
Heska Corporation
VO_0001968
Live, attenuated vaccine; Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.21)
Wyeth, Pfizer, Inc., Merial, Inc.
VO_0001969
Live, attenuated vaccine; Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.22)
Merial, Inc.
VO_0001970
Live, attenuated vaccine; Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.25)
Pfizer, Inc.
VO_0001971
Live, attenuated vaccine; Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.00)
Heska Corporation
VO_0001972
Live, attenuated vaccine; Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.21)
Merial, Inc.
VO_0001973
Live, attenuated vaccine; Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.30)
Heska Corporation
VO_0001974
Live, attenuated vaccine; Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.21)
Heska Corporation
VO_0001975
Live, attenuated vaccine; Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.22)
Pfizer, Inc.
VO_0001976
Live, attenuated vaccine; Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.20)
Boehringer Ingelheim Vetmedica, Inc., Intervet Inc.
VO_0001982
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.22)
Pfizer, Inc.
VO_0001983
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.23)
Pfizer, Inc.
VO_0001984
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.25)
Pfizer, Inc.
VO_0001985
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Hardjo Bacterin (USDA: 4L49.20)
Pfizer, Inc.
VO_0002003
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus-Mannheimia Haemolytica-Pasteurella Multocida Modified Live Virus, Avirulent Live Culture Vaccine (USDA: 11A8.22)
Intervet Inc.
VO_0002008
Live vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11A5.20)
Merial, Inc.
VO_0002009
Inactivated or "killed" vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.20)
Heska Corporation
VO_0002010
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.26)
Pfizer, Inc.
VO_0002011
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.30)
Heska Corporation
VO_0002012
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.20)
Heska Corporation
VO_0002013
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.26)
Pfizer, Inc.
VO_0002014
Live, attenuated vaccine
Licensed
USA
Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.30)
Heska Corporation
VO_0002015
Live, attenuated vaccine
Licensed
USA
Bovine Virus Diarrhea-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 12A5.20)
Novartis Animal Health US, Inc.
VO_0002028
Inactivated or "killed" vaccine
Licensed
USA
BRSV DNA vaccine VCL-Fb
VO_0004574
DNA vaccine
Research
pVCL1012 [Ref2702:Taylor et al., 2005]
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
DNA vaccine construction
Seven days after BRSV challenge, BRSV-specific serum IgA titres in calves vaccinated i.m. with VCL-Fb were significantly greater than those in calves vaccinated by the i.d. route (P < 0.05) (Taylor et al., 2005).
VO_0003057
Vaccination with DNA encoding the BRSV F protein can induce a significant reduction in BRSV excretion in young calves. At slaughter, 7 days after challenge, BRSV was isolated from the lungs of three out of four calves vaccinated with control plasmid, two out of six calves vaccinated i.d. with VCL-Fb, but none of the calves vaccinated i.m. with VCL-Fb (Taylor et al., 2005).
F
Bovine respiratory syncytial virus strain Snook
3451386
CDD:278924
GOA:O90698
HSSP:1G2C
InterPro:IPR000776
InterPro:IPR013055
UniProtKB/TrEMBL:O90698
11246
?
F protein
9.09
59125.88
632
Fusion glycoprotein F0; pfam00523
>CAA76980.1 F protein [Bovine orthopneumovirus]
MATTAMTMIISIIFISTYVTHITLCQNITEEFYQSTCSAVSRGYLSALRTGWYTSVVTIELSKIQKNVCK
STDSKVKLIKQELERYNNAVVELQSLMQNEPASFSRAKRSIPELIHYTRNSTKKFYGLMGKKRKRRFLGF
LLGIGSAIASGVAVSKVLHLEGEVNKIKNALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKELLPKVNNH
DCRISNIATVIEFQQKNNRLLEIAREFSVNAGITTPLSTYMLTNSELLSLINDMPITNDQKKLMSSNVQI
VRQQSYSIMSVVKEEVIAYVVQLPIYGVIDTPCWKLHTSPLCTTDNKEGSNICLTRTDRGWYCDNAGSVS
FFPQAETCKVQSNRVFCDTMNSLTLPTDVNLCNTDIFNTKYDCKIMTSKTDISSSVITSIGAIVSCYGKT
KCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKLEGKALYIKGEPIINYYDPLVFPSDEFDA
SIAQVNAKINQSLAFIRRSDELLHSVDVGKSTTNVVITTIIIVIVVVILMLIAVGLLFYCKTRSTPIMLG
KDQLSGINNLSFSK
Protective antigen
glycoprotein G
Bovine respiratory syncytial virus
1489813
9631274
BovRSVgp07
AF092942
NP_048054
1BRV
11246
4689
5528
+
mRNA
10.63
27981.73
257
>gi|9631267:4689-5528 Bovine respiratory syncytial virus, complete genome
TGGGGCAAATACAAGTATGTCCAACCATACCCACCATCTTAAATTCAAGACATTAAAGAGGGCTTGGAAA
GCCTCAAAATACTTCATAGTAGGATTATCATGTTTATATAAGTTCAATTTAAAATCCCTTGTCCAAACGG
CTTTGACCACCTTAGCAATGATAACCTTGACATCACTCGTCATAACAGCCATTATTTACATTAGTGTGGG
AAATGCTAAAGCCAAGCCCACATCCAAACCAACCATCCAACAAACACAACAGCCCCAAAACCATACCTCA
CCATTTTTCACAGAGCACAACTACAAATCAACTCACACATCAATTCAAAGCACCACACTGTCCCAACTAC
CAAACACAGACACCACTAGAGAAACTACATACAGTCACTCAATCAACGAAACCCAAAACAGAAAAATCAA
AAGCCAATCCACTCTACCCGCCACCAGAAAACCACCAATTAACCCATCGGGAAGCAACCCCCCTGAAAAC
CACCAAGACCACAACAACTCCCAAACACTCCCCTATGTGCCTTGCAGTACATGTGAAGGTAATCTTGCTT
GTTTATCACTCTGCCAAATCGGGCCGGAGAGAGCACCAAGCAGAGCCCCTACAATCACCCTCAAAAAGAC
TCCAAAACCCAAAACCACCAAAAAGCCAACCAAGACAACAATCCACCACAGAACCAGCCCTGAAGCCAAA
CTGCAACCCAAAAACAACACGGCAGCTCCACAACAAGGCATCCTCTCTTCACCAGAACACCACACAAATC
AATCAACTACACAGATCTAACAACACACCTCCATATAATATCAATTATGTTCATATATAGTTATTTAAAA
>gi|9631274|ref|NP_048054.1| G [Bovine respiratory syncytial virus]
MSNHTHHLKFKTLKRAWKASKYFIVGLSCLYKFNLKSLVQTALTTLAMITLTSLVITAIIYISVGNAKAK
PTSKPTIQQTQQPQNHTSPFFTEHNYKSTHTSIQSTTLSQLPNTDTTRETTYSHSINETQNRKIKSQSTL
PATRKPPINPSGSNPPENHQDHNNSQTLPYVPCSTCEGNLACLSLCQIGPERAPSRAPTITLKKTPKPKT
TKKPTKTTIHHRTSPEAKLQPKNNTAAPQQGILSSPEHHTNQSTTQI
Virmugen
A glycoprotein G deletion in bovine respiratory syncytial virus(rBRSV) and recombinant rBRSV was attenuated and provided protection against a BRSV challenge infection in calves [Ref1989:Schmidt et al., 2002].
Blodörn et al., 2014
journal
Blodörn K, Hägglund S, Fix J, Dubuquoy C, Makabi-Panzu B, Thom M, Karlsson P, Roque JL, Karlstam E, Pringle J, Eléouët JF, Riffault S, Taylor G, Valarcher JF
Vaccine safety and efficacy evaluation of a recombinant bovine respiratory syncytial virus (BRSV) with deletion of the SH gene and subunit vaccines based on recombinant human RSV proteins: N-nanorings, P and M2-1, in calves with maternal antibodies
2014
9
6
e100392
PloS one
Gershwin et al., 2017
journal
Gershwin LJ, Behrens NE, McEligot HA, Carvallo-Chaigneau FR, Crum LT, Gunnarson BM, Corbeil LB
A recombinant subunit vaccine for bovine RSV and Histophilus somni protects calves against dual pathogen challenge
2017
35
15
1954-1963
Vaccine
Merck Vet Manual: BRSV
website
Merck Veterinary Manual-Bovine Respiratory Syncytial Virus
http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/121211.htm
Schmidt et al., 2002
journal
Schmidt U, Beyer J, Polster U, Gershwin LJ, Buchholz UJ
Mucosal immunization with live recombinant bovine respiratory syncytial virus (BRSV) and recombinant BRSV lacking the envelope glycoprotein G protects against challenge with wild-type BRSV
2002
76
23
12355-12359
Journal of virology
Schrijver et al., 1997
journal
Schrijver RS, Langedijk JP, Keil GM, Middel WG, Maris-Veldhuis M, Van Oirschot JT, Rijsewijk FA
Immunization of cattle with a BHV1 vector vaccine or a DNA vaccine both coding for the G protein of BRSV
1997
15
17-18
1908-1916
Vaccine
Taylor et al., 2005
journal
Taylor G, Bruce C, Barbet AF, Wyld SG, Thomas LH
DNA vaccination against respiratory syncytial virus in young calves
2005
23
10
1242-1250
Vaccine