Bovine Respiratory Syncytial Virus 11246 Respiratory Disease Cattle Bovine respiratory syncytial virus (BRSV) is an RNA virus classified as a pneumovirus in the paramyxovirus family. This virus was named for its characteristic cytopathic effect—the formation of syncytial cells. In additional to cattle, sheep and goats can also be infected by respiratory syncytial viruses. Human respiratory syncytial virus (HRSV) is an important respiratory pathogen in infants and young children. Antigenic subtypes are known to exist for HRSV, and preliminary evidence suggests that there may be antigenic subtypes of BRSV. BRSV is distributed worldwide, and the virus is indigenous in the cattle population. BRSV infections associated with respiratory disease occur predominantly in young beef and dairy cattle. Passively derived immunity does not appear to prevent BRSV infections but will reduce the severity of disease. Initial exposures to the virus are associated with severe respiratory disease; subsequent exposures result in mild to subclinical disease. BRSV is an important virus in the bovine respiratory disease complex because of its frequency of occurrence, predilection for the lower respiratory tract, and ability to predispose the respiratory tract to secondary bacterial infection. In outbreaks, morbidity tends to be high, and the case fatality rate can be 0-20% (Merck Vet Manual: BRSV). Baboon Papio cynocephalus 9556 Bank vole Clethrionomys glareolus 447135 Bear Ursus americanus 9643 Birds Passeroidea 175121 Brown Trout Salmo trutta 8032 Buffalo Bison bison 9901 Carnivores Vulpes 9625 Cat Felis catus 9685 Catfishes Siluriformes 7995 Cattle Bos taurus 9913 Chicken Gallus gallus 9031 Chimpanzee Pan troglodytes 9598 chinchillas Chinchillidae 10150 Copper Pheasant Syrmaticus soemmerringii 9067 Deer Cervus elaphus 9860 Deer mouse Peromyscus maniculatus 10042 Dog Canis familiaris 9615 Ducks Anas 8835 Ferret Mustela putorius furo 9669 Fish Hyperotreti 117565 Gerbil Gerbillina 10045 Goat Capra hircus 9925 Gray wolf Canis lupus 9612 Guinea pig Cavia porcellus 10141 Hamster Mesocricetus auratus 10036 Horse Equus caballus 9796 Human Homo sapiens 9606 Macaque Macaca fascicularis 9541 Mongolian Gerbil Meriones unguiculatus 10047 Monkey Platyrrhini 9479 Mouse Mus musculus 10090 None None Parrot Psittacidae 9224 Pig Sus scrofa 9823 Rabbit Oryctolagus cuniculus 9986 Rainbow trout Oncorhynchus mykiss 8022 Rat Rattus 10114 Raven Corvus corax 56781 sei whale Balaenoptera borealis 9768 Sheep Ovis aries 9940 Squirrel Spermophilus richardsonii 37591 Tree shrew Tupaiidae 9393 Trouts, salmons & chars Salmoninae 504568 Turkey Meleagris gallopavo 9103 Vole Microtus ochrogaster 79684 Water buffalo Bubalus bubalis 391902 Bovine Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1161.00) Heska Corporation VO_0001875 Live, attenuated vaccine Licensed USA Bovine Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1161.20) Heska Corporation VO_0001876 Live, attenuated vaccine Licensed USA Bovine respiratory syncytial virus glycoprotein G mutant vaccine VO_0002951 Live, attenuated vaccine Research intranasal immunization intranasal immunization Gene mutation This glycoprotein G mutant is from Bovine respiratory syncytial virus (Schmidt et al., 2002). A glycoprotein G mutant is attenuated in calves (Schmidt et al., 2002). A glycoprotein G mutant induces significant protection in calves from challenge with wild type BRSV (Schmidt et al., 2002). Bovine Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1095.20) Boehringer Ingelheim Vetmedica, Inc., Merial, Inc. VO_0001558 Inactivated or "killed" vaccine Licensed USA Bovine Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1095.21) Boehringer Ingelheim Vetmedica, Inc. VO_0001559 Inactivated or "killed" vaccine Licensed USA Bovine Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus Bacterin (USDA: 40A5.20) Boehringer Ingelheim Vetmedica, Inc. VO_0002205 Inactivated or "killed" vaccine Licensed USA Bovine Respiratory Syncytial Virus recombinant vector vaccine BHVl/BRSVG encoding the G protein VO_0004289 Recombinant vector vaccine Licensed BHVI [Ref2118:Schrijver et al., 1997] intranasal immunization intranasal immunization Recombinant vector construction The gE gene was replaced by a gene encoding the G protein of BRSV in a BHVI vector (Schrijver et al., 1997). VO_0000286 Flow cytometric analysis showed a significant relative increase of gamma/delta+ T cells in peripheral blood after BRSV challenge-infection of the calves of the control group but not in the vaccinated groups. These results indicate that the G protein of BRSV can induce significant protection against BRSV infection in cattle, and that the BHV1/BRSV-G vaccine protects effectively against a subsequent BRSV and BHV1 infection (Schrijver et al., 1997). Bovine Respiratory Syncytial Virus Vaccine Modified Live Virus (USDA: 1091.20) Pfizer, Inc., Heska Corporation VO_0001560 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.00) Heska Corporation VO_0001895 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.20) Wyeth, Pfizer, Inc., Heska Corporation, Texas Vet Lab, Inc. VO_0001896 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.21) Pfizer, Inc. VO_0001897 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.22) Pfizer, Inc. VO_0001898 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1071.23) Pfizer, Inc. VO_0001899 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11B5.20) Merial, Inc. VO_0001900 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.00) Wyeth VO_0001939 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.20) Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., Heska Corporation, Novartis Animal Health US, Inc. VO_0001940 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.21) Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc. VO_0001941 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.22) Wyeth, Intervet Inc., Pfizer, Inc. VO_0001942 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.23) Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc. VO_0001943 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.24) Boehringer Ingelheim Vetmedica, Inc. VO_0001944 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.25) Pfizer, Inc. VO_0001945 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.26) Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc. VO_0001946 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.28) Pfizer, Inc. VO_0001947 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 1181.30) Intervet Inc., Heska Corporation VO_0001948 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.20) Boehringer Ingelheim Vetmedica, Inc., Merial, Inc., Novartis Animal Health US, Inc. VO_0001949 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1185.22) Wyeth VO_0001950 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.20) Novartis Animal Health US, Inc. VO_0001951 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.22) Novartis Animal Health US, Inc. VO_0001952 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B5.20) Novartis Animal Health US, Inc. VO_0001953 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.20) Novartis Animal Health US, Inc. VO_0001954 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.21) Novartis Animal Health US, Inc. VO_0001955 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.20) Heska Corporation VO_0001968 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.21) Wyeth, Pfizer, Inc., Merial, Inc. VO_0001969 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.22) Merial, Inc. VO_0001970 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1187.25) Pfizer, Inc. VO_0001971 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.00) Heska Corporation VO_0001972 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.21) Merial, Inc. VO_0001973 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine (USDA: 1189.30) Heska Corporation VO_0001974 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.21) Heska Corporation VO_0001975 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.22) Pfizer, Inc. VO_0001976 Live, attenuated vaccine; Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.20) Boehringer Ingelheim Vetmedica, Inc., Intervet Inc. VO_0001982 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.22) Pfizer, Inc. VO_0001983 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.23) Pfizer, Inc. VO_0001984 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.25) Pfizer, Inc. VO_0001985 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Hardjo Bacterin (USDA: 4L49.20) Pfizer, Inc. VO_0002003 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus-Mannheimia Haemolytica-Pasteurella Multocida Modified Live Virus, Avirulent Live Culture Vaccine (USDA: 11A8.22) Intervet Inc. VO_0002008 Live vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 11A5.20) Merial, Inc. VO_0002009 Inactivated or "killed" vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.20) Heska Corporation VO_0002010 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.26) Pfizer, Inc. VO_0002011 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine (USDA: 11A1.30) Heska Corporation VO_0002012 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.20) Heska Corporation VO_0002013 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.26) Pfizer, Inc. VO_0002014 Live, attenuated vaccine Licensed USA Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.30) Heska Corporation VO_0002015 Live, attenuated vaccine Licensed USA Bovine Virus Diarrhea-Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 12A5.20) Novartis Animal Health US, Inc. VO_0002028 Inactivated or "killed" vaccine Licensed USA BRSV DNA vaccine VCL-Fb VO_0004574 DNA vaccine Research pVCL1012 [Ref2702:Taylor et al., 2005] Intramuscular injection (i.m.) Intramuscular injection (i.m.) DNA vaccine construction Seven days after BRSV challenge, BRSV-specific serum IgA titres in calves vaccinated i.m. with VCL-Fb were significantly greater than those in calves vaccinated by the i.d. route (P < 0.05) (Taylor et al., 2005). VO_0003057 Vaccination with DNA encoding the BRSV F protein can induce a significant reduction in BRSV excretion in young calves. At slaughter, 7 days after challenge, BRSV was isolated from the lungs of three out of four calves vaccinated with control plasmid, two out of six calves vaccinated i.d. with VCL-Fb, but none of the calves vaccinated i.m. with VCL-Fb (Taylor et al., 2005). F Bovine respiratory syncytial virus strain Snook 3451386 CDD:278924 GOA:O90698 HSSP:1G2C InterPro:IPR000776 InterPro:IPR013055 UniProtKB/TrEMBL:O90698 11246 ? F protein 9.09 59125.88 632 Fusion glycoprotein F0; pfam00523 >CAA76980.1 F protein [Bovine orthopneumovirus] MATTAMTMIISIIFISTYVTHITLCQNITEEFYQSTCSAVSRGYLSALRTGWYTSVVTIELSKIQKNVCK STDSKVKLIKQELERYNNAVVELQSLMQNEPASFSRAKRSIPELIHYTRNSTKKFYGLMGKKRKRRFLGF LLGIGSAIASGVAVSKVLHLEGEVNKIKNALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKELLPKVNNH DCRISNIATVIEFQQKNNRLLEIAREFSVNAGITTPLSTYMLTNSELLSLINDMPITNDQKKLMSSNVQI VRQQSYSIMSVVKEEVIAYVVQLPIYGVIDTPCWKLHTSPLCTTDNKEGSNICLTRTDRGWYCDNAGSVS FFPQAETCKVQSNRVFCDTMNSLTLPTDVNLCNTDIFNTKYDCKIMTSKTDISSSVITSIGAIVSCYGKT KCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKLEGKALYIKGEPIINYYDPLVFPSDEFDA SIAQVNAKINQSLAFIRRSDELLHSVDVGKSTTNVVITTIIIVIVVVILMLIAVGLLFYCKTRSTPIMLG KDQLSGINNLSFSK Protective antigen glycoprotein G Bovine respiratory syncytial virus 1489813 9631274 BovRSVgp07 AF092942 NP_048054 1BRV 11246 4689 5528 + mRNA 10.63 27981.73 257 >gi|9631267:4689-5528 Bovine respiratory syncytial virus, complete genome TGGGGCAAATACAAGTATGTCCAACCATACCCACCATCTTAAATTCAAGACATTAAAGAGGGCTTGGAAA GCCTCAAAATACTTCATAGTAGGATTATCATGTTTATATAAGTTCAATTTAAAATCCCTTGTCCAAACGG CTTTGACCACCTTAGCAATGATAACCTTGACATCACTCGTCATAACAGCCATTATTTACATTAGTGTGGG AAATGCTAAAGCCAAGCCCACATCCAAACCAACCATCCAACAAACACAACAGCCCCAAAACCATACCTCA CCATTTTTCACAGAGCACAACTACAAATCAACTCACACATCAATTCAAAGCACCACACTGTCCCAACTAC CAAACACAGACACCACTAGAGAAACTACATACAGTCACTCAATCAACGAAACCCAAAACAGAAAAATCAA AAGCCAATCCACTCTACCCGCCACCAGAAAACCACCAATTAACCCATCGGGAAGCAACCCCCCTGAAAAC CACCAAGACCACAACAACTCCCAAACACTCCCCTATGTGCCTTGCAGTACATGTGAAGGTAATCTTGCTT GTTTATCACTCTGCCAAATCGGGCCGGAGAGAGCACCAAGCAGAGCCCCTACAATCACCCTCAAAAAGAC TCCAAAACCCAAAACCACCAAAAAGCCAACCAAGACAACAATCCACCACAGAACCAGCCCTGAAGCCAAA CTGCAACCCAAAAACAACACGGCAGCTCCACAACAAGGCATCCTCTCTTCACCAGAACACCACACAAATC AATCAACTACACAGATCTAACAACACACCTCCATATAATATCAATTATGTTCATATATAGTTATTTAAAA >gi|9631274|ref|NP_048054.1| G [Bovine respiratory syncytial virus] MSNHTHHLKFKTLKRAWKASKYFIVGLSCLYKFNLKSLVQTALTTLAMITLTSLVITAIIYISVGNAKAK PTSKPTIQQTQQPQNHTSPFFTEHNYKSTHTSIQSTTLSQLPNTDTTRETTYSHSINETQNRKIKSQSTL PATRKPPINPSGSNPPENHQDHNNSQTLPYVPCSTCEGNLACLSLCQIGPERAPSRAPTITLKKTPKPKT TKKPTKTTIHHRTSPEAKLQPKNNTAAPQQGILSSPEHHTNQSTTQI Virmugen A glycoprotein G deletion in bovine respiratory syncytial virus(rBRSV) and recombinant rBRSV was attenuated and provided protection against a BRSV challenge infection in calves [Ref1989:Schmidt et al., 2002]. Blodörn et al., 2014 journal Blodörn K, Hägglund S, Fix J, Dubuquoy C, Makabi-Panzu B, Thom M, Karlsson P, Roque JL, Karlstam E, Pringle J, Eléouët JF, Riffault S, Taylor G, Valarcher JF 2014 9 6 e100392 PloS one Gershwin et al., 2017 journal Gershwin LJ, Behrens NE, McEligot HA, Carvallo-Chaigneau FR, Crum LT, Gunnarson BM, Corbeil LB 2017 35 15 1954-1963 Vaccine Merck Vet Manual: BRSV website http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/121211.htm Schmidt et al., 2002 journal Schmidt U, Beyer J, Polster U, Gershwin LJ, Buchholz UJ 2002 76 23 12355-12359 Journal of virology Schrijver et al., 1997 journal Schrijver RS, Langedijk JP, Keil GM, Middel WG, Maris-Veldhuis M, Van Oirschot JT, Rijsewijk FA 1997 15 17-18 1908-1916 Vaccine Taylor et al., 2005 journal Taylor G, Bruce C, Barbet AF, Wyld SG, Thomas LH 2005 23 10 1242-1250 Vaccine