Listeria monocytogenes
1639
L. monocytogenes may invade the gastrointestinal epithelium. Once the bacterium enters the host's monocytes, macrophages, or polymorphonuclear leukocytes, it becomes blood-borne (septicemic) and can grow. Its presence intracellularly in phagocytic cells also permits access to the brain and probably transplacental migration to the fetus in pregnant women. The pathogenesis of L. monocytogenes centers on its ability to survive and multiply in phagocytic host cells (Wiki: L. monocytogenes). Listeria is able to move from cell to cell via actin motility (Ramaswamy et al., 2007).
Listeriosis
Infection is often controlled by cell mediated response. Infection is asymptomatic in most patients, and tends to be more severe in immunocompromised individuals (Ramaswamy et al., 2007).
Listeria can live in the intestines of humans, animals and birds without causing symptoms. Mice are used as a model of infection for listeria (Ramaswamy et al., 2007).
Listeria monocytogenes is a gram positive facultatively intracellular foodborne pathogen, which is often found in food and elsewhere in nature. Listeria can survive temperatures from below freezing to body temperature (Ramaswamy et al., 2007). Infection by L. monocytogenes causes the disease listeriosis. The manifestations of listeriosis include septicemia, meningitis (or meningoencephalitis), encephalitis, corneal ulcer, pneumonia, and intrauterine or cervical infections in pregnant women, which may result in spontaneous abortion (2nd/3rd trimester) or stillbirth (Wiki: L. monocytogenes).
Baboon
Papio cynocephalus
9556
Bank vole
Clethrionomys glareolus
447135
Bear
Ursus americanus
9643
Birds
Passeroidea
175121
Brown Trout
Salmo trutta
8032
Buffalo
Bison bison
9901
Carnivores
Vulpes
9625
Cat
Felis catus
9685
Catfishes
Siluriformes
7995
Cattle
Bos taurus
9913
Chicken
Gallus gallus
9031
Chimpanzee
Pan troglodytes
9598
chinchillas
Chinchillidae
10150
Copper Pheasant
Syrmaticus soemmerringii
9067
Deer
Cervus elaphus
9860
Deer mouse
Peromyscus maniculatus
10042
Dog
Canis familiaris
9615
Ducks
Anas
8835
Ferret
Mustela putorius furo
9669
Fish
Hyperotreti
117565
Gerbil
Gerbillina
10045
Goat
Capra hircus
9925
Gray wolf
Canis lupus
9612
Guinea pig
Cavia porcellus
10141
Hamster
Mesocricetus auratus
10036
Horse
Equus caballus
9796
Human
Homo sapiens
9606
Macaque
Macaca fascicularis
9541
Mongolian Gerbil
Meriones unguiculatus
10047
Monkey
Platyrrhini
9479
Mouse
Mus musculus
10090
None
None
Parrot
Psittacidae
9224
Pig
Sus scrofa
9823
Rabbit
Oryctolagus cuniculus
9986
Rainbow trout
Oncorhynchus mykiss
8022
Rat
Rattus
10114
Raven
Corvus corax
56781
sei whale
Balaenoptera borealis
9768
Sheep
Ovis aries
9940
Squirrel
Spermophilus richardsonii
37591
Tree shrew
Tupaiidae
9393
Trouts, salmons & chars
Salmoninae
504568
Turkey
Meleagris gallopavo
9103
Vole
Microtus ochrogaster
79684
Water buffalo
Bubalus bubalis
391902
L. monocytogenes DNA Vaccine encoding hly
VO_0004031
DNA vaccine
Research
pCR3.1 plasmid vector (Invitrogen)
Intramuscular injection (i.m.)
Intramuscular injection (i.m.)
The hly gene of L. monocytogenes
DNA vaccine construction
BALB/c
For immunization with the plasmid constructs, 6-to 8-wk-old mice received the first of a series of three i.m. immunizations (via the tibialis anterior muscles) at 3- to 4-wk intervals with ~100–125 µg of plasmid DNA in 50 µl of normal saline. Normal control mice received either no immunization or were immunized with either 0.2 ml of PBS (i.v.) or 50 µl of saline (i.m.) (Cornell et al., 1999).
DNA immunization of mice provides protection against challenge with viable L. monocytogenes (Cornell et al., 1999).
Briefly, groups of normal or immunized BALB/c mice received an i.v. injection with ~2 LD50 (~20,000 CFU) of L. monocytogenes in 0.2 ml of PBS, at 3–4 wk following the final immunization with plasmid DNA. Control groups consisted of normal (nonimmunized) mice and mice previously immunized (4–12 wk earlier) with a sublethal injection of viable L. monocytogenes (Cornell et al., 1999).
L. monocytogenes p60 Protein Vaccine
VO_0004032
Subunit vaccine
Research
Intraperitoneal injection (i.p.)
Intraperitoneal injection (i.p.)
p60 protein
Recombinant protein preparation
BALB/c
BALB/c mice (two mice/group) were immunized i.p. with 100 μl liposomes containing approximately 3 μg of p60 antigen shown (Grenningloh et al., 2008).
Mice immunized with p60 encapsulated in liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes (Grenningloh et al., 2008).
BALB/c mice were immunized with encapsulated p60 and challenged intravenously on day 9 after immunization with 5 × 10^3 (1 × LD50) L. monocytogenes (Grenningloh et al., 2008).
Listeria monocytogenes actA mutant vaccine
VO_0002776
Live, attenuated vaccine
Research
Intravenous injection (i.v.)
Intravenous injection (i.v.)
Gene mutation
This actA mutant is from Listeria monocytogenes (Darji et al., 2003).
An actA mutant is attenuated in mice (Darji et al., 2003).
An actA mutant induces significant protection in mice from challenge with wild type L. monocytogenes (Darji et al., 2003).
Listeria monocytogenes actA/plcB mutant vaccine
Live, attenuated vaccine
Research
Intravenous injection (i.v.)
Intravenous injection (i.v.)
Gene mutation
This actA/plcB mutant is from Listeria monocytogenes (Darji et al., 2003).
Gene mutation
This actA/plcB mutant is from Listeria monocytogenes (Darji et al., 2003).
An actA/plcB mutant is attenuated in mice (Darji et al., 2003).
An actA/plcB mutant induces significant protection in mice from challenge with wild type L. monocytogenes (Darji et al., 2003).
The ΔactAΔplcB mutant is able to induce sufficient IFN-γ in mice to prevent a Th1 to Th2 switch and retains its ability to induce a strong CD8+-mediated T cell response, even though the amount of IFN-gamma produced is less than that produced after infection with the wild type strain (Darji et al., 2003).
actA
Listeria monocytogenes EGD-e
987035
16802250
lmo0204
AL591974
NP_463735
1EVH
169963
209469
211388
+
actin-assembly inducing protein precursor
4.71
68063.81
639
>gi|16802048:209469-211388 Listeria monocytogenes EGD-e, complete genome
AGTGGGATTAAACAGATTTATGCGTGCGATGATGGTGGTTTTCATTACTGCCAATTGCATTACGATTAAC
CCCGACATAATATTTGCAGCGACAGATAGCGAAGATTCTAGTCTAAACACAGATGAATGGGAAGAAGAAA
AAACAGAAGAGCAACCAAGCGAGGTAAATACGGGACCAAGATACGAAACTGCACGTGAAGTAAGTTCACG
TGATATTAAAGAACTAGAAAAATCGAATAAAGTGAGAAATACGAACAAAGCAGACCTAATAGCAATGTTG
AAAGAAAAAGCAGAAAAAGGTCCAAATATCAATAATAACAACAGTGAACAAACTGAGAATGCGGCTATAA
ATGAAGAGGCTTCAGGAGCCGACCGACCAGCTATACAAGTGGAGCGTCGTCATCCAGGATTGCCATCGGA
TAGCGCAGCGGAAATTAAAAAAAGAAGGAAAGCCATAGCATCATCGGATAGTGAGCTTGAAAGCCTTACT
TATCCGGATAAACCAACAAAAGTAAATAAGAAAAAAGTGGCGAAAGAGTCAGTTGCGGATGCTTCTGAAA
GTGACTTAGATTCTAGCATGCAGTCAGCAGATGAGTCTTCACCACAACCTTTAAAAGCAAACCAACAACC
ATTTTTCCCTAAAGTATTTAAAAAAATAAAAGATGCGGGGAAATGGGTACGTGATAAAATCGACGAAAAT
CCTGAAGTAAAGAAAGCGATTGTTGATAAAAGTGCAGGGTTAATTGACCAATTATTAACCAAAAAGAAAA
GTGAAGAGGTAAATGCTTCGGACTTCCCGCCACCACCTACGGATGAAGAGTTAAGACTTGCTTTGCCAGA
GACACCAATGCTTCTTGGTTTTAATGCTCCTGCTACATCAGAACCGAGCTCATTCGAATTTCCACCACCA
CCTACGGATGAAGAGTTAAGACTTGCTTTGCCAGAGACGCCAATGCTTCTTGGTTTTAATGCTCCTGCTA
CATCGGAACCGAGCTCGTTCGAATTTCCACCGCCTCCAACAGAAGATGAACTAGAAATCATCCGGGAAAC
AGCATCCTCGCTAGATTCTAGTTTTACAAGAGGGGATTTAGCTAGTTTGAGAAATGCTATTAATCGCCAT
AGTCAAAATTTCTCTGATTTCCCACCAATCCCAACAGAAGAAGAGTTGAACGGGAGAGGCGGTAGACCAA
CATCTGAAGAATTTAGTTCGCTGAATAGTGGTGATTTTACAGATGACGAAAACAGCGAGACAACAGAAGA
AGAAATTGATCGCCTAGCTGATTTAAGAGATAGAGGAACAGGAAAACACTCAAGAAATGCGGGTTTTTTA
CCATTAAATCCGTTTGCTAGCAGCCCGGTTCCTTCGTTAAGTCCAAAGGTATCGAAAATAAGCGCACCGG
CTCTGATAAGTGACATAACTAAAAAAACGCCATTTAAGAATCCATCACAGCCATTAAATGTGTTTAATAA
AAAAACTACAACGAAAACAGTGACTAAAAAACCAACCCCTGTAAAGACCGCACCAAAGCTAGCAGAACTT
CCTGCCACAAAACCACAAGAAACCGTACTTAGGGAAAATAAAACACCCTTTATAGAAAAACAAGCAGAAA
CAAACAAGCAGTCAATTAATATGCCGAGCCTACCAGTAATCCAAAAAGAAGCTACAGAGAGCGATAAAGA
GGAAATGAAACCACAAACCGAGGAAAAAATGGTAGAGGAAAGCGAATCAGCTAATAACGCAAACGGAAAA
AATCGTTCTGCTGGCATTGAAGAAGGAAAACTAATTGCTAAAAGTGCAGAAGACGAAAAAGCGAAGGAAG
AACCAGGGAACCATACGACGTTAATTCTTGCAATGTTAGCTATTGGCGTGTTCTCTTTAGGGGCGTTTAT
CAAAATTATTCAATTAAGAAAAAATAATTA
>gi|16802250|ref|NP_463735.1| actin-assembly inducing protein precursor [Listeria monocytogenes EGD-e]
MGLNRFMRAMMVVFITANCITINPDIIFAATDSEDSSLNTDEWEEEKTEEQPSEVNTGPRYETAREVSSR
DIKELEKSNKVRNTNKADLIAMLKEKAEKGPNINNNNSEQTENAAINEEASGADRPAIQVERRHPGLPSD
SAAEIKKRRKAIASSDSELESLTYPDKPTKVNKKKVAKESVADASESDLDSSMQSADESSPQPLKANQQP
FFPKVFKKIKDAGKWVRDKIDENPEVKKAIVDKSAGLIDQLLTKKKSEEVNASDFPPPPTDEELRLALPE
TPMLLGFNAPATSEPSSFEFPPPPTDEELRLALPETPMLLGFNAPATSEPSSFEFPPPPTEDELEIIRET
ASSLDSSFTRGDLASLRNAINRHSQNFSDFPPIPTEEELNGRGGRPTSEEFSSLNSGDFTDDENSETTEE
EIDRLADLRDRGTGKHSRNAGFLPLNPFASSPVPSLSPKVSKISAPALISDITKKTPFKNPSQPLNVFNK
KTTTKTVTKKPTPVKTAPKLAELPATKPQETVLRENKTPFIEKQAETNKQSINMPSLPVIQKEATESDKE
EMKPQTEEKMVEESESANNANGKNRSAGIEEGKLIAKSAEDEKAKEEPGNHTTLILAMLAIGVFSLGAFI
KIIQLRKNN
Virmugen
An actA mutant is attenuated in mice and induced significant protection from challenge with wild type L. monocytogenes [Ref1774:Darji et al., 2003].
Hly
Listeria monocytogenes EGD-e
VO_0012388
987033
16802248
lmo0202
AL591824
NP_463733
169963
205818
207407
+
listeriolysin O precursor
8.23
54322.11
529
>NC_003210.1:205818-207407 Listeria monocytogenes EGD-e chromosome, complete genome
CATGAAAAAAATAATGCTAGTTTTTATTACACTTATATTAGTTAGTCTACCAATTGCGCAACAAACTGAA
GCAAAGGATGCATCTGCATTCAATAAAGAAAATTCAATTTCATCCATGGCACCACCAGCATCTCCGCCTG
CAAGTCCTAAGACGCCAATCGAAAAGAAACACGCGGATGAAATCGATAAGTATATACAAGGATTGGATTA
CAATAAAAACAATGTATTAGTATACCACGGAGATGCAGTGACAAATGTGCCGCCAAGAAAAGGTTACAAA
GATGGAAATGAATATATTGTTGTGGAGAAAAAGAAGAAATCCATCAATCAAAATAATGCAGACATTCAAG
TTGTGAATGCAATTTCGAGCCTAACCTATCCAGGTGCTCTCGTAAAAGCGAATTCGGAATTAGTAGAAAA
TCAACCAGATGTTCTCCCTGTAAAACGTGATTCATTAACACTCAGCATTGATTTGCCAGGTATGACTAAT
CAAGACAATAAAATCGTTGTAAAAAATGCCACTAAATCAAACGTTAACAACGCAGTAAATACATTAGTGG
AAAGATGGAATGAAAAATATGCTCAAGCTTATCCAAATGTAAGTGCAAAAATTGATTATGATGACGAAAT
GGCTTACAGTGAATCACAATTAATTGCGAAATTTGGTACAGCATTTAAAGCTGTAAATAATAGCTTGAAT
GTAAACTTCGGCGCAATCAGTGAAGGGAAAATGCAAGAAGAAGTCATTAGTTTTAAACAAATTTACTATA
ACGTGAATGTTAATGAACCTACAAGACCTTCCAGATTTTTCGGCAAAGCTGTTACTAAAGAGCAGTTGCA
AGCGCTTGGAGTGAATGCAGAAAATCCTCCTGCATATATCTCAAGTGTGGCGTATGGCCGTCAAGTTTAT
TTGAAATTATCAACTAATTCCCATAGTACTAAAGTAAAAGCTGCTTTTGATGCTGCCGTAAGCGGAAAAT
CTGTCTCAGGTGATGTAGAACTAACAAATATCATCAAAAATTCTTCCTTCAAAGCCGTAATTTACGGAGG
TTCCGCAAAAGATGAAGTTCAAATCATCGACGGCAACCTCGGAGACTTACGCGATATTTTGAAAAAAGGC
GCTACTTTTAATCGAGAAACACCAGGAGTTCCCATTGCTTATACAACAAACTTCCTAAAAGACAATGAAT
TAGCTGTTATTAAAAACAACTCAGAATATATTGAAACAACTTCAAAAGCTTATACAGATGGAAAAATTAA
CATCGATCACTCTGGAGGATACGTTGCTCAATTCAACATTTCTTGGGATGAAGTAAATTATGATCCTGAA
GGTAACGAAATTGTTCAACATAAAAACTGGAGCGAAAACAATAAAAGCAAGCTAGCTCATTTCACATCGT
CCATCTATTTGCCAGGTAACGCGAGAAATATTAATGTTTACGCTAAAGAATGCACTGGTTTAGCTTGGGA
ATGGTGGAGAACGGTAATTGATGACCGGAACTTACCACTTGTGAAAAATAGAAATATCTCCATCTGGGGC
ACCACGCTTTATCCGAAATATAGTAATAAAGTAGATAATCCAATCGAATA
>NP_463733.1 listeriolysin O precursor [Listeria monocytogenes EGD-e]
MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDY
NKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVEN
QPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEM
AYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQ
ALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGG
SAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKIN
IDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWE
WWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE
Protective antigen
In an attempt to generate a subunit vaccine in this experimental disease model, eukaryotic plasmid DNA expression vectors containing genes encoding either the wild-type or modified forms of recombinant listeriolysin O (hly) were generated and used for genetic vaccination of naive mice. Results of these studies indicate that the intramuscular immunization of mice with specifically designed plasmid DNA constructs encoding recombinant forms of listeriolysin O (hly) stimulates peptide-specific CD8+ immune T cells that exhibit in vitro cytotoxic activity. More importantly, such immunization can provide protective immunity against a subsequent challenge with viable L. monocytogenes [Ref1497:Cornell et al., 1999].
iap
Listeria monocytogenes strain L2K3-549C1
VO_0012404
215422507
CDD:333284
1639
?
p60
10.49
13324.02
182
Cell wall-associated hydrolase, NlpC family [Cell wall/membrane/envelope biogenesis]; cl28464
>BAG85375.1 p60, partial [Listeria monocytogenes]
MSWNNLSSSSIYVGQKLAIKQTANTVTPKAEVKKEAPAAEKQAAPVVKENTNTNTNTTTEKKETTQQQTA
PKAPTEAAKPAPAPSTNTNANKTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGS
Protective antigen
Mice immunized with p60 encapsulated in liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes [Ref1520:Grenningloh et al., 2008].
Ifng (Interferon gamma)
Mouse
15978
33468859
NM_008337
NP_032363.1
MGI:107656; UniProt:P01580
10090
?
>gi|145966741|ref|NM_008337.3| Mus musculus interferon gamma (Ifng), mRNA
ATAGCTGCCATCGGCTGACCTAGAGAAGACACATCAGCTGATCCTTTGGACCCTCTGACTTGAGACAGAA
GTTCTGGGCTTCTCCTCCTGCGGCCTAGCTCTGAGACAATGAACGCTACACACTGCATCTTGGCTTTGCA
GCTCTTCCTCATGGCTGTTTCTGGCTGTTACTGCCACGGCACAGTCATTGAAAGCCTAGAAAGTCTGAAT
AACTATTTTAACTCAAGTGGCATAGATGTGGAAGAAAAGAGTCTCTTCTTGGATATCTGGAGGAACTGGC
AAAAGGATGGTGACATGAAAATCCTGCAGAGCCAGATTATCTCTTTCTACCTCAGACTCTTTGAAGTCTT
GAAAGACAATCAGGCCATCAGCAACAACATAAGCGTCATTGAATCACACCTGATTACTACCTTCTTCAGC
AACAGCAAGGCGAAAAAGGATGCATTCATGAGTATTGCCAAGTTTGAGGTCAACAACCCACAGGTCCAGC
GCCAAGCATTCAATGAGCTCATCCGAGTGGTCCACCAGCTGTTGCCGGAATCCAGCCTCAGGAAGCGGAA
AAGGAGTCGCTGCTGATTCGGGGTGGGGAAGAGATTGTCCCAATAAGAATAATTCTGCCAGCACTATTTG
AATTTTTAAATCTAAACCTATTTATTAATATTTAAAACTATTTATATGGAGAATCTATTTTAGATGCATC
AACCAAAGAAGTATTTATAGTAACAACTTATATGTGATAAGAGTGAATTCCTATTAATATATGTGTTATT
TATAATTTCTGTCTCCTCAACTATTTCTCTTTGACCAATTAATTATTCTTTCTGACTAATTAGCCAAGAC
TGTGATTGCGGGGTTGTATCTGGGGGTGGGGGACAGCCAAGCGGCTGACTGAACTCAGATTGTAGCTTGT
ACCTTTACTTCACTGACCAATAAGAAACATTCAGAGCTGCAGTGACCCCGGGAGGTGCTGCTGATGGGAG
GAGATGTCTACACTCCGGGCCAGCGCTTTAACAGCAGGCCAGACAGCACTCGAATGTGTCAGGTAGTAAC
AGGCTGTCCCTGAAAGAAAGCAGTGTCTCAAGAGACTTGACACCTGGTGCTTCCCTATACAGCTGAAAAC
TGTGACTACACCCGAATGACAAATAACTCGCTCATTTATAGTTTATCACTGTCTAATTGCATATGAATAA
AGTATACCTTTGCAACC
>gi|33468859|ref|NP_032363.1| interferon gamma [Mus musculus]
MNATHCILALQLFLMAVSGCYCHGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQI
ISFYLRLFEVLKDNQAISNNISVIESHLITTFFSNSKAKKDAFMSIAKFEVNNPQVQRQAFNELIRVVHQ
LLPESSLRKRKRSRC
IFN-gamma plays a critical role in Th1 type immune response. It is important for protection against infections by various viruses and intracellular bacteria.
Vaximmutor
The experimental data demonstrated that three time vaccinations with BCG in BALB/c mice induced strong TB Ag-specific IFN-gamma immune responses in splenocytes [Ref2101:Wang et al., 2009].
plcB
Listeria monocytogenes EGD-e
987036
16802251
lmo0205
AL591974
NP_463736
169963
211424
212293
+
phospholipase C
8.4
31887.47
289
>gi|16802048:211424-212293 Listeria monocytogenes EGD-e, complete genome
TATGAAATTCAAAAAGGTGGTTCTAGGTATGTGCTTGATCGCAAGTGTTCTAGTCTTTCCGGTAACGATA
AAAGCAAATGCCTGTTGTGATGAATACTTACAAACACCCGCAGCTCCGCATGATATTGACAGCAAATTAC
CACATAAACTTAGTTGGTCCGCGGATAACCCGACAAATACTGACGTAAATACGCACTATTGGCTTTTTAA
ACAAGCGGAAAAAATACTAGCTAAAGATGTAAATCATATGCGAGCTAATTTAATGAATGAACTTAAAAAA
TTCGATAAACAAATAGCTCAAGGAATATATGATGCGGATCATAAAAATCCATATTATGATACTAGTACAT
TTTTATCTCATTTTTATAATCCTGATAGAGATAATACTTATTTGCCGGGTTTTGCTAATGCGAAAATAAC
AGGAGCAAAGTATTTCAATCAATCGGTGACTGATTACCGAGAAGGGAAATTTGACACAGCGTTTTATAAA
TTAGGCCTAGCAATCCATTATTATACGGATATTAGTCAACCTATGCACGCCAATAATTTTACCGCAATAT
CATACCCTCCAGGCTACCACTGTGCATATGAAAATTACGTAGATACCATTAAACACAATTATCAAGCAAC
GGAAGACATGGTAGCAAAAAGATTTTGCTCAGATGACGTGAAAGACTGGCTCTATGAAAATGCGAAAAGG
GCGAAAGCGGACTACCCGAAAATAGTCAATGCGAAAACTAAAAAATCATATTTAGTAGGAAATTCTGAAT
GGAAAAAGGATACAGTGGAACCTACTGGAGCTAGACTAAGAGATTCACAGCAAACTTTGGCAGGTTTTTT
AGAATTTTGGTCTAAAAAAACAAATGAATA
>gi|16802251|ref|NP_463736.1| phospholipase C [Listeria monocytogenes EGD-e]
MKFKKVVLGMCLIASVLVFPVTIKANACCDEYLQTPAAPHDIDSKLPHKLSWSADNPTNTDVNTHYWLFK
QAEKILAKDVNHMRANLMNELKKFDKQIAQGIYDADHKNPYYDTSTFLSHFYNPDRDNTYLPGFANAKIT
GAKYFNQSVTDYREGKFDTAFYKLGLAIHYYTDISQPMHANNFTAISYPPGYHCAYENYVDTIKHNYQAT
EDMVAKRFCSDDVKDWLYENAKRAKADYPKIVNAKTKKSYLVGNSEWKKDTVEPTGARLRDSQQTLAGFL
EFWSKKTNE
Virmugen
A plcB mutant, in combination with an actA mutant, is attenuated in mice and induces significant protection from challenge with wild type L. monocytogenes [Ref1774:Darji et al., 2003].
Brockstedt et al., 2005
journal
Brockstedt DG, Bahjat KS, Giedlin MA, Liu W, Leong M, Luckett W, Gao Y, Schnupf P, Kapadia D, Castro G, Lim JY, Sampson-Johannes A, Herskovits AA, Stassinopoulos A, Bouwer HG, Hearst JE, Portnoy DA, Cook DN, Dubensky TW Jr
Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity
2005
11
8
853-860
Nature medicine
Cornell et al., 1999
journal
Cornell KA, Bouwer HG, Hinrichs DJ, Barry RA
Genetic immunization of mice against Listeria monocytogenes using plasmid DNA encoding listeriolysin O
1999
163
1
322-329
Journal of immunology (Baltimore, Md. : 1950)
Darji et al., 2003
journal
Darji A, Mohamed W, Domann E, Chakraborty T
Induction of immune responses by attenuated isogenic mutant strains of Listeria monocytogenes
2003
21 Suppl 2
S102-109
Vaccine
Grenningloh et al., 2008
journal
Grenningloh R, Darj A, Bauer H, zur Lage S, Chakraborty T, Jacobs T, Weiss S
Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help
2008
67
6
594-602
Scandinavian journal of immunology
Jiang et al., 2007
journal
Jiang S, Rasmussen RA, Nolan KM, Frankel FR, Lieberman J, McClure HM, Williams KM, Babu US, Raybourne RB, Strobert E, Ruprecht RM
Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys
2007
25
42
7470-7479
Vaccine
Orgun and Way, 2008
journal
Orgun NN, Way SS
A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Listeria monocytogenes
2008
44
2
159-163
Microbial pathogenesis
Ramaswamy et al., 2007
journal
Ramaswamy V, Cresence VM, Rejitha JS, Lekshmi MU, Dharsana KS, Prasad SP, Vijila HM
Listeria--review of epidemiology and pathogenesis
2007
40
1
4-13
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Wiki: L. monocytogenes
website
Wiki: Listeria monocytogenes
http://en.wikipedia.org/wiki/Listeria_monocytogenes