Mycobacterium avium 1764 Mycobacterium avium is sometimes found as part of a larger complex called the Mycobacterium avium complex (MAC). MAC is an opportunistic infection that takes advantage of a weakened immune system. It can infect one part of your body, such as your lungs, bones, or intestines. This is called localized infection. It can spread and cause disease throughout your body. This is called disseminated infection. With HIV, MAC infection usually happens only after you receive a diagnosis of AIDS (acquired immunodeficiency syndrome) and when CD4 cell counts drop below 50 (WebMD - Mycobacterium avium complex). Baboon Papio cynocephalus 9556 Bank vole Clethrionomys glareolus 447135 Bear Ursus americanus 9643 Birds Passeroidea 175121 Brown Trout Salmo trutta 8032 Buffalo Bison bison 9901 Carnivores Vulpes 9625 Cat Felis catus 9685 Catfishes Siluriformes 7995 Cattle Bos taurus 9913 Chicken Gallus gallus 9031 Chimpanzee Pan troglodytes 9598 chinchillas Chinchillidae 10150 Copper Pheasant Syrmaticus soemmerringii 9067 Deer Cervus elaphus 9860 Deer mouse Peromyscus maniculatus 10042 Dog Canis familiaris 9615 Ducks Anas 8835 Ferret Mustela putorius furo 9669 Fish Hyperotreti 117565 Gerbil Gerbillina 10045 Goat Capra hircus 9925 Gray wolf Canis lupus 9612 Guinea pig Cavia porcellus 10141 Hamster Mesocricetus auratus 10036 Horse Equus caballus 9796 Human Homo sapiens 9606 Macaque Macaca fascicularis 9541 Mongolian Gerbil Meriones unguiculatus 10047 Monkey Platyrrhini 9479 Mouse Mus musculus 10090 None None Parrot Psittacidae 9224 Pig Sus scrofa 9823 Rabbit Oryctolagus cuniculus 9986 Rainbow trout Oncorhynchus mykiss 8022 Rat Rattus 10114 Raven Corvus corax 56781 sei whale Balaenoptera borealis 9768 Sheep Ovis aries 9940 Squirrel Spermophilus richardsonii 37591 Tree shrew Tupaiidae 9393 Trouts, salmons & chars Salmoninae 504568 Turkey Meleagris gallopavo 9103 Vole Microtus ochrogaster 79684 Water buffalo Bubalus bubalis 391902 licensed Mycobacterium avium infection human vaccine Generic Unknown VO_0002501 Inactivated or "killed" vaccine Licensed A generic representation of vaccines utilized to prevent Mycobacterium avium infection in humans, typically employing inactivated (killed) bacterial preparations to stimulate protective immunity. These vaccines are designed to reduce the risk of infection, especially in immunocompromised individuals. M. avium DNA vaccine DNA-Av35/p2AIL12 VO_0004540 DNA vaccine Research pJW4303 [Ref2659:Martin et al., 2003] Intramuscular injection (i.m.) IL-12 (Martin et al., 2003) Intramuscular injection (i.m.) M. avium 35,000 MW protein (Martin et al., 2003) Co-immunization with p2AIL-12 and DNA-Av35 led to a significant increase in the number of antigen-specific IFN-gamma secreting cells and total amount of IFN-gamma released, but a concomitant fall in the antibody response to the 35000 MW protein (Martin et al., 2003). VO_0000286 Immunization with DNA-Av35 resulted in significant protective immunity against M. avium infection with a 2-log10 reduction in the M. avium load in the spleen (P < 0.001). The addition of p2AIL12 to the DNA-Av35 vaccine significantly increased the level of protection in both the spleen (P < 0.005) and liver (P < 0.01), with a further reduction in the bacterial load of about 1-log10 (Martin et al., 2003). Mycobacterium avium relA mutant vaccine VO_0002779 Live, attenuated vaccine Research Oral immunization Oral immunization Gene mutation This relA mutant is from Mycobacterium avium (Park et al., 2011). A relA mutant is attenuated in goats (Park et al., 2011). A relA mutant induces protection in goats from challenge with wild type M. avium (Park et al., 2011). Expression of IFN-gamma was increased. Specifically, a quantitative RT-PCR revealed the gene encoding IFN-γ was up-regulated in PBMC stimulated with live Map (a M. avium relA mutant) three months post infection compared to the response of PBMC pre-infection (Park et al., 2011). Expression of IL-17 was increased. Specifically, a quantitative RT-PCR revealed the gene encoding IL-17 was up-regulated in PBMC stimulated with live Map (a M. avium relA mutant) three months post infection compared to the response of PBMC pre-infection (Park et al., 2011). Expression of IL-22 was increased (Park et al., 2011). Expression of IL-10 was decreased. Specifically, a quantitative RT-PCR revealed the gene encoding IL-10 was down-regulated in PBMC stimulated with live Map (a M. avium relA mutant) three months post infection compared to the response of PBMC pre-infection (Park et al., 2011). Cattle peripheral blood mononuclear cells (PBMC) were used for cytokine detection (Park et al., 2011). Expression of IFN-gamma was increased in cattle PBMC. Specifically, a quantitative RT-PCR revealed the gene encoding IFN-γ was up-regulated in PBMC stimulated with live Map (WT) three months post infection compared to the response of PBMC pre-infection (Park et al., 2011). Expression of IL-17 was increased in cattle PBMC. Specifically, a quantitative RT-PCR revealed the gene encoding IL-17 was up-regulated in PBMC stimulated with live Map (WT) three months post infection compared to the response of PBMC pre-infection (Park et al., 2011). Expression of IL-22 was increased in cattle PBMC. Specifically, a quantitative RT-PCR revealed the gene encoding IL-22 was up-regulated in PBMC stimulated with live Map (WT) three months post infection compared to the response of PBMC pre-infection (Park et al., 2011). IFNG Bos taurus 281237 31982949 BOS_5228 AF140653 NP_776511 9913 5 45830157 45834980 + interferon, gamma 10.24 18866.5 166 >gi|258513362:45830157-45834980 Bos taurus breed Hereford chromosome 5, Bos_taurus_UMD_3.1, whole genome shotgun sequence AATTAGAAAAGAAAGATCAGCTACCTCCTTGGGACCTGATCATAACACAGGAGCTACCGATTTCAACTAC TCCGGCCTAACTCTCTCCTAAACAATGAAATATACAAGCTATTTCTTAGCTTTACTGCTCTGTGGGCTTT TGGGTTTTTCTGGTTCTTATGGCCAGGGCCAATTTTTTAGAGAAATAGAAAACTTAAAGGAGTATTTTGT AAGTATGATCTTTTAATGAGACTTTCTTGTGATTGAAATGACTTGATGTTTGATGTTGACTTGGAATTCT ATCTATGATGGGCTCTCATCTCTAGTCTTCAGTCATTTTGAGAAGACTTGCTGTTATTGTGACTGTTAGC TAGATGTGTTTGTTTGTTTGGTTTTTTTTTTTTTTCTGACTAAACAATCTCTGCTCAGTTTGCTATAGAG ATTTAGAAGGGATTCATGAATCTTTCAAAAGATGGGCATAATATGTGTATACATCATAGTGTTGATATTT TGTGATAAGAATCCATTCAACTATGATGTTAAGTAGCAAGCATACTGAAAAGACAGCTGAGTCTTAATTT TTGATTTCTCATGTTACTATAATGATGACAGTCAGAAGTCAAGATCAGCATTAAAAATGGTCATTTGACA TAATTGATCAATTAAAGAAGATGAGGTCCTTAAATATTTGGCTTAAAAACAAAAACACTTATAGGTGTTT TTCTCTAAAAAGTCATTTTAAAATTTTACTATCCCATCTAGATTGTCTGTGAATTACTCTTGGACTCAGT CACTTGCTGAGATTTTTTTTGTAGGAGTTATAATCTAGTTTATATTTTAAAAAATTTTTTGTCTTGTTTT AGGAATTTCTTAAAAATTTACTTATGGTTAATTAAAATAGCTTGGGCATTTTAAATATTTTATCATATAT CCAAATTTAGCTGTTATAATTATAGCTGGAGCTATCTTTTAAAGGCGATATAATACCTTATAGGAGGACA CAGGTAGAGGTTATGAACCGTATACCATAGGGGGGCAGTATTTTATAGTGAGATGATGTTGTTGATTTTT TTTTTTTTTTTAACTATACCTTTTTCTTACCATAGTAATTTGGGACAGTTGAAGTATCATCAGTCTTGAA TGAGTTCATTGTGATGTTATATTAGTAAATAAGAAAGCAAAAATCACATGATAGTCTTTGGCTGTTATCC AACCAGGTAGCTTTTGTGAATATTTTTTGTTAAAACTAAACAGTGTTGAAAAGAAAATCAGTAAATAGTG CCAGCATCCAAGTTCAATAAAACTTGAGGTACATTTTTACAGCAATTTATGGACTAATTTTAAGCCAATT TTTTATTGTGTTGTTTTATTTTCCAGAATGCAAGTAGCCCAGATGTAGCTAAGGGTGGGCCTCTCTTCTC AGAAATTTTGAAGAATTGGAAAGATGTAAGCTGAACATTTCCATTTGGCTGATTTTCCTGTTGCTTTTTT TCTGATGGATAAATTCACATCAACCTCTCTTTGTGCTCTTTTCTCCCAAGGAAAGTGACAAAAAAATTAT TCAGAGCCAAATTGTCTCCTTCTACTTCAAACTCTTTGAAAACCTCAAAGATAACCAGGTCATTCAAAGG AGCATGGATATCATCAAGCAAGACATGTTTCAGAAGTTCTTGAATGGCAGCTCTGAGAAACTGGAGGACT TCAAAAAGCTGATTCAAATTCCGGTGAGATGATCTTAATGCTTTCTTTGGTATCATTGCAGAGGCTCTTA CAAAGCACTTCATTCCCAGAAAATAGAAATTAGATACCAGGTGTAAAGCTCTGAAGTGAACTTGTGGTCA AAATGCCTCTTTGCTAGTTCTCTTTTGACTTGGGTGACTTTGCCGAGTCAGTTATTGGAGGCACTTAAGT CTGTGATTTTGGGAAAATACTGGCATTATGCCTATCGCACAAAGATGGGTGAATGGACAAATCAGTGAGG AGGAAGCAGAGAAGGAGTTGGGGTGATGGGGACAGAGTACTGAAAACCAGTTCTCCCATTGCCCCTTGTC TGTGTGTTGGAAATTCTCTTGCTTTGAATAGGTTGCATGTCTTAATGGAAAGAGCAGTGGGAGGGAAAGG GAAGAAGATGTGTGCTCCGCCCAGCTTAGCCACCAAAGAAATGTGTGACTTCAGATGAATCACAGGCCTG GCTGGGGCTGTTTCCTCATCTTAAAAGGAGCCTGTTGAGTTCACTGTAATTTCTACGGTCTCCTTTGCTC TAAAATTCTACAATGCCATGGAAAGAAAATGAGAATGAGATAGGAGAAAGGAATAGCCTTTGAGGAGACA AAGGCCCTCCCACTGTCGAACTCTGGTCAATCACCCAGATTGTATAGCCCAAGGAGAGGTGACTGCGTTT GTTTTTAGAAAGAAAATAGGTAGAATTGTCCTATCAATGAATTTTTAAAGTTTTTAGAAGCTGAAAGATC ACTTTGAAGCATAAGGACAAGTCACATTTTCCAAAATTTCACCTAAGGGACAACGGTCTCCAGATTTTTT TGCGGGGGAGAGTTGGCTTTTGTATAAATAGGCTTGGGTGAGAAGAGGAGGGGTCCCATTATGACTTGTG CTTTCAGGATTTGTACCAGCTCTTGCTCTAACCTGGTCTGCCTCTCAACAATCTCATATAAGCTCCCAGG AACTGAAATAAGTGGTTGCTCTTCAAGATTTCTCTAGTCTCCCATATATTAGATGGTATGAGAGTGGCTT GGAAAAATTATATGTAATGTTTTCCATGTTCAGCAGATCTCCATTGGTTGCAGGCTAGAGAATGAAAAGG CACTGTTCCTGACCCAGTGCTGCCTCTGGTTGCTGTTCAGTCCTAGAGAAGTCCCTTAGTTTCTTGGTGA TGCTTAGAAAACTGGAAAGTTATCACTTGTAAACACACAGCTGGTAGAAATTTTTCTACTCTGTTGTAAC TGGGCCTTGAAAACAATAGGTTGGTCCCATCCTTCTGGAAGCTCCAAGCCTCCTTCTTCACAATGTGCAA TCTTGAGTGAGTGCTCAACCATTGTCGTCTTTTGCTCAAATGTGAACATATTTAAGGCACGTTTTGCCTT TTTGTCTTGTAACTTAGAATCTCCTAGTCATTCTCAGAAATGTGGCAAGGTGGCTGCAGTGTTTCAGCTT TAGAAAGAAATGTAGTGGCAGAGCAAAGATGAAAGCAAATGGTCCTCATTTTATGAAGCATGAATTCACC TATATTGTCCTACTGGGAAGAGTGAGAAAATAGTTCAATTTGCTGGAGTGGAAGGCAGGGTACCGGGAGA TTGCTTTCATTTCTAACTTTATTATATAATACCAGTAATTGATTACTACCTTTAAATAAGATCCGTGTTT ATTTTTAATCCCATCATGGAAACAATGAGACTGACCTAATTTGGAGGAAATTAAAAATAATGGTTTTCCT CCTTCTAGAACTTGGTGTTTATAAAGTACTGAACCTATACCAATGGTTTTCAAACTTGGGTGGTGCCTAA ATCACCTGGTGATGTTGGTAACCACACAATGGCCCAGGCCTAGTCCGATTTCACCCATCTGGGTGTCAGA GTTCTTCATTAGGTCCTCAGGTTACTCTTTTACGCACCAAACATGAGAGCCATTGGCTATAGTAACTCAT TTGATGCTTACAGCGAAGACTAAGTACTAAGTGATAGCAGTGACGGAGACCCTAGGGATCATCTAAACAC TCTCCTCATACTTAGTGGAGAAAACAGAGATCTGGAGAGCCTCAGTGACTGGTTTAAAGTCAGATGTATT GCACACACAGAATTCACACCCACATTTTTCTGTCACTCTACTTCTGGGGTTTTTTCACTATATAATTTTC AGATCTCTGAAGTGGTAAATTTATGAATATGTGATGTGCTCCATCCTGTTACAGTACAACTATCAATTGA ATTGTTATAATTTTAGTTTTTATCACTGAAGAAACCAACATTACATATTAAGGTTCATTACTGCTAGTGA AAATAATTTGTTTTAAAGAATACTTTGATTTTCTTGGGCCTAGACAGCAGAATATCCTAATGACTCATAG GCCTGAAATTAATTTTGCTGTTTTCTTTCCCAATAGGTGGATGATCTGCAGATCCAGCGCAAAGCCATAA ATGAACTCATCAAAGTGATGAATGACCTGTCACCAAAATCTAACCTCAGAAAGCGGAAGAGAAGTCAGAA TCTCTTTCGAGGCCGGAGAGCATCAATGTAATGGTCCTCCTGCCTGCAATATTTGAATTTTTAAATCTAA ATCTATTTATTAATATTTAATATTTTACATTATTTATATGGGGGATATATATTTAGACATCAAAGTATTT ATAATAGTAACTTTTATGTCATGAAAATGAGTATCTATTAATATATGTGTTATTTATAATTCCTGTATCC TGTGACTATTTCACTTGACCCTTTTTTTTCTGAGTAACTAGGCAAGTCTATGGGATTTCAAGGTTTTATC TCAGGGGCCAACTAGGCAGCTAACCTAAGCAAGAATCTGTGGGTTGTGCACTTATTTCACTTGATGATGT AATGAATGCTGATAAATGAAATGATGCCATCTAGTCACTACTTATCTGAGACTAGATCTGGATTCTGAGC CACTACTTTGATGGCATGTCAGACAGCACTTGAATGTGTCAGGCTATATGACTTGTGCCCTGACAAAAAC ATAGCATCTCATCTCACCTTATACCTGGCGCTTCAGGATATCACTGACAATTGTGATTACACCCAAATGG AAAGTAATATGTTTGTTTAGTTTATCAATATTTAATATATATGAATAAAGTATAATTTCATAAC >gi|31982949|ref|NP_776511.1| interferon gamma precursor [Bos taurus] MKYTSYFLALLLCGLLGFSGSYGQGQFFREIENLKEYFNASSPDVAKGGPLFSEILKNWKDESDKKIIQS QIVSFYFKLFENLKDNQVIQRSMDIIKQDMFQKFLNGSSEKLEDFKKLIQIPVDDLQIQRKAINELIKVM NDLSPKSNLRKRKRSQNLFRGRRAST Vaximmutor IL10 Bos taurus 281246 41386772 BOS_15514 GJ062448 NP_776513 9913 16 4402473 4406411 - interleukin 10 8.14 19616.38 178 >gi|258513351:4402473-4406411 Bos taurus breed Hereford chromosome 16, Bos_taurus_UMD_3.1, whole genome shotgun sequence AAATAGCTCACAGAGAAGCTCAGTAAATAAATATATGTGGGAGCTGAGGTATCAGAGGTAATAAATACTC TAGGGGAGAGGCACAGTACAGGTCTCCAGGGAGCTGGCTCTGCTCTCCCAGAACCCTGGATTGGATTTCA GAGGTCTTCCGTTTACGTCATGGAGTCTAGTAGAGTCACCATCCTGGAGGTCTTCTTCCCTAGAATGCTT CACTTTTGCATCTTCGTTGTCATGTAGGTTTCTATGTAGTTGATGAAGATGTCAAACTCACTCATGGCTT TGTAGACACCCCTCTCTTGGAGCTGTGTGGGGAGACAAGACGTGTTCAGTGAAAACTCCCTCTGAGCAAG TGAGTGGGTCCCTGCTGGGAAGGTCATGACCCTGGGCCCAGAGGCTGCACTAGCTTGCTTGCATTGGGAG ATGAAGGACAGACTCTGGGCATCTGGAGAGATGCCGGACTGTCAGCAAAGGCTATGCGTTGCCCTGGACC TTGCCCGGTGGGCAGCAAGAGGAACATTCACTTTGCAAAGTGTGGTTTTTCGAACGGTGCTTTTCCAGCA ATTTTAAACGTCATGTGCTCACGTGACGCTTATTCAATATCTGATGAAAACACATTAGCGGAACCACTTT GAAAGAAAGACAATGAGAGAGAGAGAGAGAGGTAGCCTTGTTCCTGTTTATGTTCCCCCACCCGTGGAGT GAGCAGGCCCAGCCCCGCTGCTCTGACCTACTGCAGGGAGGTTCATGGCCCCTGATACTGGAACCTGCCC AGGGTCTGTCCCCCACCCACGAGGAGGACATAGGTTCCGCGGCTTCTGGAAAATGGGGTAGAAGAGCTCA TGGACAGCTGGAAGTGAGAAAGGCCACTTCGTTTGAGAGCTGAGATTCTCAGGTGCCTTGTGTGGTGAGG CTGGCGGGTGGAAAGAGAGGGGTCAAGTCAGGTAAGGAGAGCTCTGCTTCCTGCTCTGGGCTCGGGGTGC TCAGGCTGCGCCCCTGGGTGTGTTTGTAAGTGCACGTTCACGTGTCAGCTTCCTGCACGTGCGGCTTCAG ACTGGATCCCAACAAGCTACTTTCTGTTTCCTCTGTCACTCTCCCCAGCACCCCGCTCGCTGTGTTCACA GCTGGCGGGCCAGCCCAACCGGCAGGCCTGCGAAGGCAGGGAGCAGTCATTTAGAAACCCCCAAAGACAC TTCACAGAAAACAAATATAACTGAGGTGGCGGCCCCTCACTGGATGAAGAGGTCACCCCACTTGCCGGGT TCCCACACTCCCTCCGAGCAAAGTTCAGGGCCTGCTGAGCACCTGCCCACCTCTGCCCCTTCGAGAGTGG ATGGAGGTCACGGTCCTCAGGCCCTCCCTGCCAGCAGCCCAGCCTCACCTCACTGAAGACTCTCTTCACC TTCTCCACCGCCTTGCTCTTGTTTTCGCAGGGCAGAAAGCGATGCTGTGGAAAAGGAGAGAGTATGAGCA ACATTGGTGGCTGGTCCCAGATGCACCGTGCTTGGGAGACAGCCTGGGAGCAGGAGGAGGCCAGCTCATC TTGAAGGCCCACCCTGCATCTCAGGGAGGACTGAGCCTGGGCACCCTTCCCCACCAGGCAGAGAGGAAGC ACAGCAAGGCAGGGGCCAGGCGGCATGTGTGTCTCTAGGAGCTCCTCCCCACCGTTAACAAGGCTGCATC AACACCTCTGTCTTGGAGTTTCCTTCCGGGCGCATCCCAGTGCCAACCAGACTGCTGAGCCAGCCCTTCT TCCATCCTGTCCTGCTTCTGGCCTGTCCCCCTCCTTGGTCCCAGCCACAAGGACCATTTCTAAGTGCCCC GCAGAGCAGAGACACAGGGTCAGCCCTGCCAGCCAACCCCCTTGCCTAGCGCTGTCCTGCAAATACAGCC CAACTGATTTCTCAACATCGGCGAGGGAGCAGAGGAAACTGGTGGGGAGGGTATCATTGCAGTTGGAGGG ATCAGTAATCCTGGGGGATTATTCGCAGACACTAGCCTGGGACCAAGGATCCCCCTGGCTCTTCTAAAAT GCCAGGACAGTCCTGGCAGTCAGCCGGGCCCCACCTGAAGCTCTGCTTTCAAAAGGTCGAGAAGAAGAGG AAGGGGCCTTCCCTCTCCCAGGCCCTCTGCTTCTGCCTGCTTCCGTGGGGCCCAGGGCCTCTGTCCCCAG GGACAAGGGAGCCCTGGCTGAAGCTCTGGGCCCCTTTCACGTCGAGGCCGGGGACTGCTAATAACCCACA AATGACTCACAAATAACAGGAAAGCTATTGCAAATCTTCACATGTAAGCACTCAGCAACCACCCCCACCC GCGGCTCAGAAACAGCCGAGCCAGGCCTGGGGTTCCGGAGGGGCAGGGGCCCCGAGGGCTGGTGTCCCGG GGTCTCTGGGCGAGAGCAGAGCTTGAAGAGGAGGTCTCAGCACGAGCCCAGAGGAGCCAGAGCTGGCCTG CTACTCACACAGCGCCGCAGCCGCAGCCGGAGGGTCTTCAGCTTCTCCCCCAGTGAGTTCACGTGTTCCT TGATGTCAGGCCCGTGGTTCTCAGCCTGTGGCATCACCTCTTCCAGGTAAAACTGGATCATTTCCGACAA GGCTTGGCAACCCAGGTAACCCTGAGGGCGGAAACCAAGGCGGGTGGTGACCCGGGAGGAAGGGCTACAC TGCCTGAGAGGACGGCTCTGTTCCCCAAGGACCTTGTTCAGTGGCCACCTCCCCCTGGAACGGAGCCCTT GGCAACACCCAACACCCTGCCTCCCTCTGGCTATGTGCTGAGTTAAGATCTTCCCACTTCTCCTTTTTTT GAAGTGAAGGAAGCAGACCCAGCTCCCTGCAGGCGAAGAAGCAGAGTCTCCCTTGGGCACACCGCAAGCT CCTTGCCCCCGCCAAACGCACTCACCCCAGCCCTCACCTTAAAGTCATCCAGCAGAGACTGGGTCAACAG TAAGCTGTGCAGTTGGTCCTTCATTTGCTGCAAGAAGAACAGAAGGAGAATGAACCCAAGGTTTGGAGCA ATACTGAGAAGGACTGTCTTTCTGATATCCTTTTATTGAGAGACTTTTTGATTTTTAGTCAACACAGCCC TGTCTCCAAAAGGGAAAGGAGAGGTTTTGAAACAGGACATTCAGCAGCGCTGAAGCCCTTAGTTAAACCA GGTCCTTCCTCCGGGGATCAAGTTCTTTTAAAAACCTGGCTGATTTTGAAGGCAAGGCAGAAGCCTGCCT GGGTCCCAGTCTTCTTTCTGTAGAGCTGCGTCACGTGTGCAGGGACCCCCATTCCCAACCCCTCAGCACC CTCTGCTTTGCTGTCTCCAGCTGCAGCACTGACCGTTCTCTGGGAGTGGCAAGCATCTTCTCCTGCAGGT CTCCCCCTGTATGCGCTACCTCCAACCCATTTGTCATTCAGGTTCTGGAAGCCCTCCAAGCTGAGGCAAC TTTTGTATCCCTGCCACGGGGTTTTGGGAACATCTTCACCTCCAATCAGATCTCTCCCAGCCAATGAGGT ATTGAGCTCCAGAGGAATCCTTTACAGATTTTCTAGCATAGGCTAGATGTGCCTTTACATTTTTAAAGAC AACTTTTCTTGCACAATCTGCTACATCACCAGAGCTCAGATTAACTCACTGAACCCACAGTTTGACCAGG GACTCTTAAGAATTTCAGCTTCGAGGGGAATGGGTGCTGAGGGTGGAGGTGAGTGAAAAGGAGGCTCTTG TGAGTGCCTGCAGAATGGCTCTTCCTGCGGTCCTAAGGGAGAAATGAAGGACAGGAGGGCTTTATACTCA CAAAGAAAGTCTTCACCTTGCCGAAGGCAGCTCGGAGCTCCCGCAGCATGTGGGGCAGGCTGGTTGGCAA GTGGATACAGCTGCTGTCAGACAGGGTGCTCGCATCTCGGCTGGCTGCCACCCCAGCCAGGAAGACCAGG CAACAGAGCAGGGCTGAGC >gi|41386772|ref|NP_776513.1| interleukin-10 precursor [Bos taurus] MHSSALLCCLVFLAGVAASRDASTLSDSSCIHLPTSLPHMLRELRAAFGEAKTFFQMKDQLHSLLLTQSL LDDFKGYLGCQALSEMIQFYLEEVMPQAENHGPDIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVE KVKRVFSELQERGVYKAMSEFDIFINYIETYMTTKMQK Vaximmutor IL17A Bos taurus 282863 56605852 BOS_21471 AF166487 NP_001008412 9913 23 24346987 24350508 + interleukin 17A 9.15 15852.85 153 Also known as IL17; IL-17 >gi|258513344:24346987-24350508 Bos taurus breed Hereford chromosome 23, Bos_taurus_UMD_3.1, whole genome shotgun sequence TGTCCATCTCACAGCGAGCACAAGTTCATCTGTCTACAGTGAACTGGAAGGAACTACCATGGCTTCTATG AGAACTTCATCTATGGTGAGTCCTGAACTGATGTGTGATTCTCTTCTCGATTTAGGCCAGATCAATTTCT GGACTGCGGGCATGAAATTCTGGATTCTAACTATGGAAATACAGTCTATATAGGATGGGAAATGAAACCC TTGATAGATATTTGTCATTATTGAGCATTTTCAAGAACTGGTGCATATCAGTTTGAAAGATGAGATTAAA ACTGAAAGATAGCTAGACTGGGGCTAAACCACACAAGAAGTGTCAACGTGACATTGTGCTGTAAGAGAGA ATGCTTATTGAAAATCTGTTTCTCTGGGTACAAGGGATTTAATATAATTCTTCCACAGTGTTTTTCTTTA ATTCAAAATAAGATGGGTCACTACCCTTGAAGATTTAATGTTTTGGCAGTGACTCTTCTTTCCATTATTG TATTATTATACTATAGTCTTGGTACACTAACCCTATTTTCTTAGGTATGTTTCCCAGCTTTTCCAAATTT ACATATATTGATTCTGTAATCAAATTGGATTTCAAAAAAGATGCTTTAACAATATTTTAAAAACAGAGAC CTTTTAATTCTAATCTAAAGTTATACATGCGTCTTTTTTGAAACCCAATTTGATTACAGAATCAATATAT GTAAATTTAGAAAAACTGGGAAATATACTTAAGAAAATATAAGAGGGTGTTGAGTTTGGGCTTGGACATT TGCCAGTGGTACCAACAGAATTTCTAACTGATTCCACATGGATTTTATACAGCCCTTTATGTCTAAGGTG TGCATTCCCTTTTATGCAATGTTTCACAAAATGTAAGAGGAGATATCAATGGTGTAGAAGGGCATTTCTT CCTAGAAAATCAAGGTCATTACCCTTCCAAAGACCTGAGAGTGATGCATATACTGATATATTGATGACTT GCCATCTTCACTAAAATTACTGTCAGCCAATGAATAATGTGGTTTTTCTACTTTAAAAAAAAATGTTCAA GACTGGTAGAAATGCCATGGTCCTAATGTCACTTTAGTCATCTCATCAGCTTTTCACTTAACATATTTGA AAATTTAGTATAGATTGTCCTGGACCATAGAATGTTCTCTACTATCAGCAATTTAATCATTACCACAGTG TGTTAACAAAAACCATTGTAGTACTAACCCAATCTACCTCTCTCTCCATCCAGTCACTGCTACTGCTTCT GAGTCTGGTGGCTCTTGTGAAGGCAGGAGTCATCATCCCACAGAGTCCAGGCTGCCCACCTACTGAGGAC AAGAACTTCCCGCAGCATGTGAGGGTCAACCTAAACATCGTTAACCGGAGCACAAACTCCAGAAGGCCCA CCGATTATCACAAGCGCTCCACCTCACCTTGGACTCTCCAGTACGTAAGCACCCCAGATAAAACCTCTGC ATTCTTCTACATCAGAAGAACACATCAGACTGCCAGTTAAATCATCTGAGGGGGGTGATATTACTCATTC AGAATCACCTGTCAAACCTGGAAGAGCCATTGTTCAAACTAGTGATTCTCCAATTTTCTTTCTACAGATT TCTTTCATAGATCACAGCTCTCCCCAGCCCATCCATAACACCTAGCCTACGAGTTCTCGATGTCCCCAGA ATCCACTTAAATGAATGGTGGTCATCATTCTGATATTTATGACACCCCAAGTCTATTGTTTATTTACCCA AAAAAGAAACAGACATTTAGCATGGGAGATTAGTACTGGAATTCTCTTTCCCAGGGCTACCAGAGAATAC CCTGGTAGAGTTTGTTGACAACAACAATCAATTAACTGGGATTTTTGTGCTTTTCTTGGTTATATTAGCA CTGGGAAAAGTGGATTAGCTACTGGATTAGCTTGAATCCCAGTAGAAGAAGTGTTCCATTGGGTGTTTCA CCGTTTTTTGACTTAGTCTTGAATTACATCCCCAACAGACTGACATTCGCTGTGTCTTTAATACATCTAG TGGTGGTGGTGGTGGTGGTGGTTTAGTCGCTAAGTCGTGTCCGATTCTTGTGATCCCATGGACTGTAGCC CACCAGGCTCCCCTTTAGACCCTATGATGGATCAAATACAAAATGCATTTTGATAATTTGATTTCAGGCA AATGATCTCAGTTATGTGGAGCCTACAGATTCACTTGTCTATAGGGTCTTTTCTTCTTACTTACTTACTT ACCAAGAATAGTTCAAATAACTTAAACTAAGTCCAATCACTCTCTCAGCCAGAGGAGAGGGAGAAGGGAA AGTTACAGAGGGGCTTCAGATATTGTTTCCAGCCCTTCCTGTCACCCGTGGGCTCTGCTCCATCAGTGTG TTGTCAGATAAATTTGGATGCCTTTCTTGTTTCAAAGACAGACTTCATTAAGTCAGATTAGCAGCTATCT TGTTTCTAGATGACTCTTAGTTTTTTTAATCTATCAAATGCACCCTAAAAAAATATCCTTTATGACAAAC AAATCCTTTCTGTAGTTTCAGTCTGTCTTCTTTTGTTTATTCTTCAAAGAACCTGGGGAAAGCTGATCAT TGTTTCTTTTTTCTGTAACATTTCATGGGCTTCCAAATCCAAGTTTTTCCCAAATGGCTTGTTTTCCAGA CTAATAGCACTTAGAGAATTTGCAATGCCTATCATGTCAATTTGCCTCCCTTTGCTTATTCCTGTTTGAT TTCCTTACTGCTCTACCAGGAATTCACTTTCTTCCTGGCTTTTGTCTCCCCTGCAGCCGCAATGAGGACC CTGAGAGGTACCCCTCTGTGATCTGGGAGGCCAAGTGCAGCCACTCAGGCTGTATCAATGCTGAAGGCAA GGTGGACCATCACATGAACTCTGTCACCATCCAGCAAGAGATCCTGGTCCTCCGAAGGGAGTCTCAGCAC TGCCCTCACTCCTTCCGGCTGGAGAAGATGCTGGTGGCCGTGGGCTGCACCTGCGTCACCCCCATTGTCC GCCATTTGGCTTAAGAGCTTTCTGCCTGACCCCTACTCCCCAAATTAGTTAGGTTTCCTGGGGAGTAGGC CCAGCCCCTTTTCTAACTAACATCATTTATGTATTTAATAAGCCCTGAAATAACTTTGGGGCATAAGATT CCACTTTGATGTATTACATGCTTTATTTTCTATTCTTTTAAGACAAGTTTCCAGATTTGTGAATATTATT ATTTAAAAGGTAGAACCTATATTTATATGAGCTATTTATGGATCTATTTATGTTTCATTAGTCTTTAGAA AAAAGGTGAAATATATGAGTATCTGTTTTGCCTAGGGAAATCCTAGATAGGATTAAATAGCAGTTGAAAA TGTCTGAGCTTGTACTACATATGGCTATAGAATTTTCTCTTGCTTGTCTCTTTGGAGTACATAACACAGC TGAAAAGAGACTAAATTTAGTTTCATATTTATTAACTTAATTTTGTAAATTATTGAGGCATTACAAGAGA GACAGCAAGTCTAACTGCTCTA >gi|56605852|ref|NP_001008412.1| interleukin-17A precursor [Bos taurus] MASMRTSSMSLLLLLSLVALVKAGVIIPQSPGCPPTEDKNFPQHVRVNLNIVNRSTNSRRPTDYHKRSTS PWTLHRNEDPERYPSVIWEAKCSHSGCINAEGKVDHHMNSVTIQQEILVLRRESQHCPHSFRLEKMLVAV GCTCVTPIVRHLA Vaximmutor IL22 Bos taurus 507778 148356272 BOS_5234 EF560595 NP_001091849 9913 5 45721766 45727534 + interleukin 22 9.05 20001.55 190 Also known as IL-22 >gi|258513362:45721766-45727534 Bos taurus breed Hereford chromosome 5, Bos_taurus_UMD_3.1, whole genome shotgun sequence CACAAGCAGAAGCCTCGATACAGGTAAGTCCTCCAACGAACTTGGTAGGATTGGCTTGCTGGGTCTATTC CTTCTGGATACTTAATTTTTTCCCTTAATGTTGATTTTGTTTCTCGTTCTCTTGATACCAGGTTCTTCTT CCCTAGTCACCCATTGCTCAGGTTTGCTTTGTCCACGATGGCTGCCCTGCAGAAATCTGTGGGCTCTCCT CTCAGGGACACTCTGGCCGCTGGCTGCCTCCTTGTCATGGTGCTGTGCGCCCAGAGAGGAGCGGCTGCAC CCATCACGTCGCACTGTAGGCTCAACGAGTCCGACTTCCAGGAGCCCTACATCTTCAACCACACCTTCAC TCTGGCTCAGAAGGTACTCATCTCAGTCTTTCTCTTTTGCATCTTATCTACTTGGAACCTGAATAGTTCT TAAAATTTCTTCAGAGGACATCTAAGATCTTTAACAGATGAACATTAATCGCTGCTGGTATACCTGTCAT CATTTTCTATGTCTCTTTTAAGACTTTTTGGAGATCAAGCTTTACCTCAAGCCCTTCCATTTGCCCGTTA GGAAATGTACATTCAGTTTTACCCCCAAAGGGGCCATGTAGTAACCCATCTGACTGTTTATGGTTCCCTT TACTTCTCTAAGCATTCTTTTAGTTTTTGAAGAGAAAGAAATTGACATTTTTGAGCACTTACTATGTTAT GAGCTCTATTCTAGGAGCTTTAAATCCATTCTTTCTTTTTTACTGAAGTATAGTTCATTGACAGTATTAT TTAAGTTCCAGGTATACAGCATAGTGATCCACAATTTTTAAAGATTATTCTCCATTTATAGTTATTATAA CATATTGGCTATATTACCTATGCTGTACATTATACTGTTCTATCTTATTTTTTAAATTTATTTTGAAGTA TAGCTGGTTTACAGGGTCATGTTAGTTTCCAGTGTACAGCACGCTGATTCAGGTCTATATATATATATAA ATATACGTACATATGTGTATATATAATATATGCATATTCTTTTATATATTATTTCCCCTTATTGGTTATT ATAAAATATTGAGTATAGTTCCCTGTACTATTTAGTAACTTCTTATTAGTTGTCTATTTTATACATTGTA GTGTATATATGTTACTCCCAAACTTCTAATTTATCCCTCCCCTCAACCCCTGAGCATCATTTTAAACCCA TGCACTAAAGAATCCTTTCTTTAGTCTTCACAGTGCTGCTCTGGGAAGAGGGGACAGAGTACAGCTTTGC TTACAGACATTTCTTCTAGCTTTATGATGTCCAGGCACTTAGTCTTTTCTTTTCTTCTAGGCTAGTTTGG CAGATAACATCACAGATGTTCGTCTCATTGGGAACAAATTGTTCCACGGAATCCATGTAAGCCATAGGCA TGATGCCACTTGTGGTTACTTGGAGTGGTGGTGAGGATGGGCTGGGTCTTGTGGATGTCGCCTAATTTGA GCCCTGCTGTTTCACTTTCACCAGCAGGTGACGAAGCGCTGCTACGTGCTGAAGCAGGTGCTGAACTTTA TTCTTGAAGAGGTGCTGTTCCCCCAATCTGACAAATTCCACCCCTATATGGAAAAGGTGGTGCCCTTCTT CTCCAGGCTCAGCAAAAAGCTAAGCCAATGTGTAAGTTCTTCTCCAGCCTGAGTCCAATCCTCCCAGTGC CTGCCTTTCCTCTTTCTTCTGTGTAGAACCCTCTTCCTTCCCACCCCAGTGCCCCTTCCATGCTGGTAGT GAGAGGTGCCTCTGTCACACCATTACAGAAATCATTTGGCATCACAACCTGTTTGCTTTTGCTTTAACTG AGTCACATTTTGAGTTGATTGTGATGGGCAGGGTCTGATAGACCACAGGAGGCTCATTTGTCCCTGGGAA AAAGCGATTTGGACTCTGTGAGATGAGAAAGGTGTTGGGAGCTGTAAGGAAAAATACCTATTGGTGCAAA TGGATTCACTGAATATAAGTTGATGGAGGGAGGGGATGGGAAAGAGAGAAAGGGAGAAACAAGATTTAAT ATTCGGCAGTGGGTGGGTGGATGAAGACTGCTGCCCTTTTGATAATGGAAGTGACAAAATCAGAGGTGCA TGAGTTTGATGCCTCTGAATATTGAAAACTAAGAAAAATATTTTGGTGGAGTAGGCTGAGCAAAAGGGGC CTACTATTTATTGAGGAGGGCCCTGTTCACATAAGATGTTTTATGTAGGTTTCTTGTTCTGAGCCCATGT TTTTGATGAGGTGCCGTTATGGTTTTATTCTTGACAGGATTTGCATAAACCACTCCGCTCTTTCCACAAA CTTCAACCTCATTAGGGTTGCCCAGAGGTGAAGTGAGGTCCCGTGTAAGGGAAATGACTGGATTTTGGTG TCCCAGGGAATTGAAGAGGTCAGAAAATCTAGGTCACTATTGATATCTAGGTCATTGTGGGCAAAATTGC TAAGAACTTTAATTCCAGATGAATTGTAACATACTTCAGTTAGGAAGGCTGAGTTTCAAAATCTTCAGTA CAACAATGTTAAACTTGTTACTCTCATTTCCATTTTGTAGCATGTTGAGTCTGACAACCAGCACATCCAG AGAAATGTACAGAATCTGAAGAACACAGTGAAAAAGGTACTACTAACAACTATTAGTACTAAATCATTTG ATAGAAGAGACAAATATTGTTTTTCTTCCCTTTCTTTCCTTTTTTCTCCCACGTCATGATTTTTTACTTG ACTCTCCTGCCATTGGGTTGATTATTCAGGTGCACATTAAGTATAGATGTGTCTATGCTATGCTATGCTA AGTCACTTCAGTCGTGTCCGACTCTGTGTGACCCCCCAGACGGCAGCCCACCAGGCTCCCCCATCCCTGG GATTCTCCAGGCAAGAACACTGGAGTGGGTTACCATTTCCTTCTCCAATGCATGAAAGTGAAAAGTGAAA GTGAAGTCGCTCAGTCGAGTCCGACTCTTAGCGACCCCATGGACTGCAGCCTACCAGGCTCCTCCATCCA TGGGATTTTCCAGGCAAGAGTACTGAAGTGGGGTGCCATTGCCTTCTCCGTAGATGTGTCTACATGTTTA TAAGTCAGTTTCCAAATTTTGCAAATTCTAGAACTGGCTGGGAACTTAAGACATTGACTTATTGTCACCC ATGTGCTAGGGATGGCCAGTGTCAGAGTCAGAATAGACTGCAGGACCTCTGAATCCCATCCAGGCCAGAA GTGCTGGATATTATACTTAGTCTCATTAGTTCTTAGGGAAATTTTAGATACCTACTGATTCATTTAGTCT GAAGAAGCATTTGTTCAAAACCCAAAACTGGGTAAAACTTATTTGAAAGAATTTTGAAGTCATTCACATG ATGATGTAAAACTTGAGAAATATACCTAGAACAGCCATAATAAAAGAGCTGGACTTTCACATAGGATGAA TTTCTGGAATGGTTTGATACTTATATTTAACTATTAAAATACCCAGCAGCTATTGGTTTTAATTTAAAAG TGAGAGTGAATGTCCCCCCAGTCTCTTTTACACAGTATCAAATAGAATAGAAATATTACTATTAGTAATG GATTCATTGTAGGGAAATGAATGTCCACACCGGAAGCCCTCTTTCTTCCTCTTTCCTTTTCCTTCTTTCC TGGTCTATTCTTTCCCTTGACAATGTGCTAATGAGCATCTATCTGATATAGTTTAGTGTATATTTTGACA GAGAATGATATTGTCGGGTGGCCTATTTGGGGGGAAAGAACAACAGGGGAAGGCTCAGCTCAGCTGCTGT GACTCATCCAAAAACCAGAGCTACCATGAGCAGCAGCAAAAGTGAGGATTTGGTAGGCAGGTACAATTAA ACCTCAGAAACAAGAATGCTCTGGTTGATGGAATTTTCAGTAACAAGCATAACCTCAATTCCCCCTTTTT TCCATCTTGATTTTTTAAATAAAAAGTATCTCTTCCTGAATGTGATTTAATGAACATTGTCAATGTCTTC CTTTGATAACTTAAGGATTTGTTTTTTTCATTGTGAAGATAAATTCTCTTGTCATAGAACGATTAGCTAG ACACAGAGGGCTGAATATTAGCATGCCATAGCCAAGAAGTACTTTGCATTTCTGGTGTGAAAAATTCCTC ATATGAGCTTACTTTGTTGTCTTTAGAAAAGTGGAGTGTGGGAGACAAAAAGCTGATGGTGATTTGTGTG GGAAAACAGATTTTAAAGCTCTTAATCCATTTTGAAGGAATTGACTTACACATTAGCAATCAGTTGCCAT GTGGATGAGTTGTTATGCTTTTTTTTTTTTTTTACCCTGTAGTTTCAGAAAGCCTAGTGAGAGAGGAATA TTATTTAGAGAAATCTCAGCATGCGTAAACACTGGTCAGCACTATGAAATGGGAGGGCATCTTGGGGGGA TAGTAATCCCTTGTCACTGAAGAAAAGTAGAAAGCAGGCTGTAGCAGAACAGAGAACAGATAGTAGAATT GTTTATCATCTTGGGAGTCTTTGAGATATTAAAAAAATATCTCTTGTCGTTATGTCAAAGGAAGTATCGA AAGGTGGAAAGATGGAAGAAAGCAGGAAGAGAAAGACCAAAGTCTAGAGGACAATGATGACTTAGGGTTG CTGTTTTCTTTGAAATAATCTTGAGCACATTTAATAGATTAGACAAGTTTCAGAGGAGGGGATTTAGACT TGTGTTCCCTCTCCCATGGGGTTTAAAAGACTTTTGCCTACTACTTGGAAGGAGGAGGAAAGAAAGGGTG TTAGACTGTATCTGGCCTTTCACTGTTAAAGCAACTAGATAGGAGACATTTGATATTTCCCCCACAAAAG TGAAAACTTGTTTTCCCCACCTTGGTCAAGAAAGTGGAAACAGAAATAGTCCACATGTTTTGGTACATGT GGTAGTTTTGGTTCAAGACTATTGGAGTTGAGTGGTTATACTAACTGATTGGTCACAGCAGTCATGGGAC TCAGAGGCAGGGCAAGGAGGGGTGAGTGGTGCTTGGGTCCCCCAGATCCCCCAACAGCCTCTACCTGCTT GCTCTGGTTCAGCAGTGATTTAACACATCAACCAGCTGAGACTGATGCCCATAGGTGCCCTCTCAGATCA GGTCATATATTTTGAAAAAGGGTATTATCACTAATCTTTTATAAAATGTTAAAACTTGGTTTCTGTTCCA ACAACCTAACCATCTCATCTCTCTCTAATTTGTTTCTCTTTAGAAAACATGGTATAAATGCTGAAATACT TGTGTGTTCTTATTTTCACAGCTTGGAGAGAGTGGAGAGATTAAAGTCATTGGAGAACTGAACTTGCTGT TTACAACCCTGAAACGTGAATGTGCTCAAGTAGACCAAGGCTGGAAAATGGGTTACTAACCTTTCTCACC TGCTAAACAATAAGATCCCCTGAGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNACAAAAAAGATTACT TTCTATCTCTTTAGAAAAAGCCCCTAAATAACTTCATTTCCATAATCAATACTTTATATTTATGAATTAA TTTATTGTTATAAGTACATGTCTTATTATTTATGTCACTTTATAATATGGGTTTATTTATGGAAGCATTA TAAAATATTTCTACTTAATTATAAGGTGAATAGTAATATTTATGATAATAATTATGGAGTTATGTTTATT TAGTCTCAATAAACACATCGATATCCTAA >gi|148356272|ref|NP_001091849.1| interleukin-22 precursor [Bos taurus] MAALQKSVGSPLRDTLAAGCLLVMVLCAQRGAAAPITSHCRLNESDFQEPYIFNHTFTLAQKASLADNIT DVRLIGNKLFHGIHQVTKRCYVLKQVLNFILEEVLFPQSDKFHPYMEKVVPFFSRLSKKLSQCHVESDNQ HIQRNVQNLKNTVKKLGESGEIKVIGELNLLFTTLKRECAQVDQGWKMGY Vaximmutor relA Mycobacterium avium subsp. paratuberculosis K-10 2717869 41407145 MAP1047 AE016958 NP_959981 262316 1095829 1098195 + RelA 7.63 79917.73 788 >gi|41406098:1095829-1098195 Mycobacterium avium subsp. paratuberculosis K-10, complete genome CGTGGCGGAGGAAAACAGCGCGGCGCAAGCGCTTGACGCGCCGGCGGAGTCGCCGCCCAACCCGGTGATC GAGACTCCCGAGCCGCCGACCGAATCGCTCAAGACGTCCAGCAGCGCGTCGCGCCGGGTCCGGGCCCGGC TGGCCCGGCGGATGACCGCCCAGCGCAGCACGCTCAACCCGGTGCTGGAGCCGCTGGTGGCGATGCACCG CGAGATCTACCCCAAGGCCAACGTGCAGCTGCTGCAGCGCGCATTCGAGGTCGCCGACCAGCGGCACGCC AGCCAGTTGCGCCACTCCGGCGACCCCTACATCACCCATCCGCTGGCCGTCGCCACCATCCTGGCCGAAT TGGGCATGGACACCACCACTTTGGTGGCCGCGCTGTTGCACGACACCGTCGAGGACACCGGCTACACCCT GGCCCAGCTGTCCGAGGAATTCGGCGAAGAGGTCGGTCATCTGGTCGACGGGGTGACCAAGCTGGACCGG GTGGTGCTGGGCAGCGCCGCCGAGGGCGAGACCATCCGCAAGATGATCACCGCGATGGCCCGCGACCCGC GGGTGCTGGTGATCAAGGTCGCCGACCGGCTGCACAACATGCGCACCATGCGGTTCCTGCCGCCGGAGAA GCAGGCCCGCAAGGCCCGCGAGACGCTGGAAGTCATTGCGCCCCTCGCCCATCGGCTGGGCATGGCCAGC GTCAAGTGGGAGTTGGAGGACCTGTCGTTCGCCATCCTGCATCCCAAGAAGTACGACGAGATCGTCCGGC TGGTCGCCGGCCGGGCCCCGTCGCGGGACACCTACCTGGCCAAGGTGCGGGCCGAGATCATCAACACGCT GAACGCGTCGAAGATCAAGGCGACGGTGGAGGGCCGGCCCAAGCACTACTGGTCGATCTACCAGAAGATG ATCGTCAAGGGCCGCGACTTCGACGACATCCACGACCTGGTCGGCATCCGCATCCTGTGCGACGAGATCC GGGACTGCTATGCCGCTGTGGGCGTGGTGCATTCGCTGTGGCAGCCGATGGCCGGGCGGTTCAAGGACTA CATCGCCCAGCCGCGCTACGGCGTCTACCAGTCGCTGCACACCACCGTCGTCGGGCCGGAGGGCAAGCCG CTGGAGGTGCAGATCCGCACCCGCGACATGCACCGCACCGCCGAGTACGGCATCGCCGCGCACTGGCGCT ACAAGGAAGCCAAGGGCCGCAACGGCGTTCCGCACCCGCACGCCGCCGCCGAGATCGACGACATGGCCTG GATGCGCCAGCTGCTCGACTGGCAGCGGGAAGCCGCCGACCCGGGCGAATTCCTCGAGTCGCTGCGCTAT GACCTTGCGGTACAAGAGATCTTCGTGTTCACCCCCAAGGGCGACGTGATCACCCTGCCCACCGGGTCGA CGCCGATCGACTTCGCCTATGCCGTGCACACCGAGGTCGGGCACCGCTGCATCGGCGCCCGGGTCAACGG CCGGCTGGTGGCGCTGGAACGCAAGCTGGAAAACGGGGAAGTCGTCGAGGTTTTCACCTCCAAGGCGGCC AACGCGGGCCCGTCGCGGGACTGGCAGCAGTTCGTGGTGTCGCCGCGGGCCAAGGCCAAGATCCGGCAGT GGTTCGCCAAGGAGCGGCGCGAGGAGGCCCTGGAGGCCGGCAAGGACGCGATGGCCCGCGAGGTGCGCCG CGGCGGACTTCCGTTGCAGCGCTTGGTCAATGCCGAATCCATGAGCGCGGTGGCCCGCGAACTGCACTAC GCCGACGTGTCGGCCCTCTACACCGCGATCGGTGAGGGGCATGTGTCGGCCCGGCACGTGGTGCAGCGGC TGCTGGCCGAGCTCGGCGGCATCGACCAGACCGAGGAGGACCTCGCCGAGCGGTCCACCCCGACCACCAT GCTGCGCCGCCCGCGCAGCAGCGACGACGTCGGCGTGTCGGTGCCCGGCGCCCCGGGCGTGCTGACCAAG CTGGCCAAATGCTGCACGCCGGTGCCTGGGGACCAGATCATGGGATTCGTCACCCGCGGCGGCGGGGTGA GCGTGCACCGCACCGACTGCACCAACGCCGCCTCGCTGCAGCAGCAGTCCGAGCGCATCATCGAGGTGCA CTGGGCGCCGTCGCCGTCGTCGGTGTTCCTGGTGGCCATTCAGGTCGAGGCGCTCGACCGGCACCGGCTG TTGTCCGACGTCACCCGGGTGCTGGCCGACGAGAAGGTCAACATCCTGTCCGCGTCGGTCACCACCTCCG GTGACCGGGTTGCCATCAGCCGCTTCACCTTTGAGATGGGCGACCCCAAGCACCTCGGCCACCTGCTCAA CGTGGTGCGCAACGTCGAAGGCGTCTACGACGTCTACCGGGTGACCTCCGCCGCCTG >gi|41407145|ref|NP_959981.1| RelA [Mycobacterium avium subsp. paratuberculosis K-10] MAEENSAAQALDAPAESPPNPVIETPEPPTESLKTSSSASRRVRARLARRMTAQRSTLNPVLEPLVAMHR EIYPKANVQLLQRAFEVADQRHASQLRHSGDPYITHPLAVATILAELGMDTTTLVAALLHDTVEDTGYTL AQLSEEFGEEVGHLVDGVTKLDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEK QARKARETLEVIAPLAHRLGMASVKWELEDLSFAILHPKKYDEIVRLVAGRAPSRDTYLAKVRAEIINTL NASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGIRILCDEIRDCYAAVGVVHSLWQPMAGRFKDY IAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVPHPHAAAEIDDMAW MRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPIDFAYAVHTEVGHRCIGARVNG RLVALERKLENGEVVEVFTSKAANAGPSRDWQQFVVSPRAKAKIRQWFAKERREEALEAGKDAMAREVRR GGLPLQRLVNAESMSAVARELHYADVSALYTAIGEGHVSARHVVQRLLAELGGIDQTEEDLAERSTPTTM LRRPRSSDDVGVSVPGAPGVLTKLAKCCTPVPGDQIMGFVTRGGGVSVHRTDCTNAASLQQQSERIIEVH WAPSPSSVFLVAIQVEALDRHRLLSDVTRVLADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLN VVRNVEGVYDVYRVTSAA Virmugen A M. avium relA mutant is attenuated in calves and goats. This mutant also elicited an immune response in goats that limited colonization by challenge wild type M. avium [Ref2026:Park et al., 2011]. Martin et al., 2003 journal Martin E, Kamath AT, Briscoe H, Britton WJ 2003 109 2 308-314 Immunology Park et al., 2011 journal Park KT, Allen AJ, Bannantine JP, Seo KS, Hamilton MJ, Abdellrazeq GS, Rihan HM, Grimm A, Davis WC 2011 Vaccine WebMD - Mycobacterium avium complex website http://www.webmd.com/hiv-aids/guide/aids-hiv-opportunistic-infections-mycobacterium-avium-complex