VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Cov19VaxKB
Host Responses
VaximmutorDB
VIGET
Vaxafe
Vaxar
Vaxism
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign2
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UM Logo

Vaccine Detail

SARS-CoV pCI-N DNA from vaccine
Vaccine Information
  • Vaccine Name: SARS-CoV pCI-N DNA from vaccine
  • Target Pathogen: SARS-CoV
  • Target Disease: Severe Acute Respiratory Syndrome (SARS)
  • Type: DNA vaccine
  • Status: Research
  • Host Species for Licensed Use: None
  • Host Species as Laboratory Animal Model: mouse
  • Antigen: S protein (Zhao et al., 2005)
  • nucleocapsid protein (N) gene of SARS-CoV gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
  • Description: A plasmid pCI-N, encoding the full-length N gene of SARS-CoV, was constructed and expressed in Escherichia coli DH5alpha (Zhao et al., 2005)
Host Response

Mouse Response

  • Host Strain: Balb/c(Zhao et al., 2005)
  • Vaccination Protocol: 200 μg of Vaccine 573 in both tibialis anterior muscles three times at 2-week intervals (Zhao et al., 2005)
  • Immune Response: Anti-N immunoglobulins (specifically IgG2a) and splenocytes proliferative responses against N protein, splenocyte production of IFN-γ, IL-2, IL-4, IL-10, production of N-specific CD8+ T cells, delayed-type hypersensitivity response
    (Zhao et al., 2005)
  • Side Effects: Delayed hypersensitivity response (Zhao et al., 2005)
References
Zhao et al., 2005: Zhao P, Cao J, Zhao LJ, Qin ZL, Ke JS, Pan W, Ren H, Yu JG, Qi ZT. Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine. Virology. 2005; 331(1); 128-135. [PubMed: 15582659].