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Vaccine Detail
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Epivac vaccine |
| Vaccine Information |
- Vaccine Name: Epivac vaccine
- Target Pathogen: Helicobacter pylori
- Target Disease: Ulcers
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Host Species as Laboratory Animal Model: Mice
- cagA
gene engineering:
- Type: Recombinant protein preparation
- Description: Compared to non-immunized mice, immunization with Epivac alone or with a Th1 adjuvant significantly reduced H. pylori colonization, and better protection was observed when an adjuvant was used (Li et al., 2012).
- Detailed Gene Information: Click Here.
- Adjuvant:
- Adjuvant name:
- VO adjuvant ID: VO_0001237
- Description: In six groups, mice (n = 10) were immunized three times at two-week intervals with PBS, Epivac or Epivac plus one of the following four Th1 adjuvants: CpG ODN 1826 (CpG, 20 μg/mouse, synthesized by Invitrogen), N-glycolyl-MDP VacciGrade (MDP, 30 μg/mouse, InvivoGen), MPLA VacciGrade (MPLA, 10 μg/mouse, InvivoGen) and Addavax (1:1, InvivoGen) (Li et al., 2012).
- Immunization Route: subcutaneous injection
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| Host Response |
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| References |
Li et al., 2012: Li HB, Zhang JY, He YF, Chen L, Li B, Liu KY, Yang WC, Zhao Z, Zou QM, Wu C. Systemic immunization with an epitope-based vaccine elicits a Th1-biased response and provides protection against Helicobacter pylori in mice. Vaccine. 2012; 31(1); 120-126. [PubMed: 23137845].
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