• Vaccine Name: rORFV-RabG
• Target Pathogen: Rabies virus
• Target Disease: Rabies
• Vaccine Ontology ID: VO_0004766
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• RABVgp1 nucleoprotein N gene engineering:
  • Type: Recombinant vector construction
  • Description: Orf virus (ORFV) recombinant, D1701-V-RabG, expressing the rabies virus (RABV) glycoprotein that is correctly presented on the surface of infected cells without the need of replication or production of infectious recombinant virus(Amann et al., 2013).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001108
  • Description: (Amann et al., 2013)
• Preparation: Orf virus (ORFV) recombinant, D1701-V-RabG, expressing the rabies virus (RABV) glycoprotein (Amann et al., 2013).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Mice were i.m. immunized once, twice, or thrice with 10^7 PFU of D1701-V-RabG in 2-week intervals. Two other groups were vaccinated three times with 10^6 PFU either i.m. or s.c (Amann et al., 2013).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Two weeks after the last immunization, all mice were i.c. challenged with 3,000 mouse i.c. LD50 of the highly pathogenic RABV CVS-11 strain (Amann et al., 2013).
• Efficacy: All i.m. immunized animals, receiving one, two, or three inoculations of 10^7 PFU or three doses of 10^6 PFU, were completely protected, whereas 4 out of the 5 s.c. immunized animals survived the challenge. The D1701-V-RabG-immunized and protected mice did not reveal any harmful reaction, loss of body weight, or RABV-specific clinical signs (Amann et al., 2013).