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Vaccine Detail
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SG33-VP2/5 |
| Vaccine Information |
- Vaccine Name: SG33-VP2/5
- Target Pathogen: Bluetongue virus
- Target Disease: Bluetongue disesase
- Vaccine Ontology ID: VO_0004706
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Vector:
- Preparation: MYXV expressing the immunodominant VP2 protein (SG33-VP2) (Top et al., 2012)
- Immunization Route: Other
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| Host Response |
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Sheep Response
- Vaccination Protocol: Sheep were injected twice with an MYXV expressing the immunodominant VP2 protein (SG33-VP2) (Top et al., 2012).
- Vaccine Immune Response Type: VO_0000287
- Immune Response: The SG33-VP2 vector promoted the production of neutralising antibodies (Maclachlan et al., 2009).
- Efficacy: The SG33-VP2 vector expressing VP2 partially protected sheep against disease after challenge with a highly virulent strain of serotype-8 bluetongue virus (BTV-8) (Top et al., 2012).
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| References |
Maclachlan et al., 2009: Maclachlan NJ, Drew CP, Darpel KE, Worwa G. The pathology and pathogenesis of bluetongue. Journal of comparative pathology. 2009; 141(1); 1-16. [PubMed: 19476953].
Top et al., 2012: Top S, Foucras G, Deplanche M, Rives G, Calvalido J, Comtet L, Bertagnoli S, Meyer G. Myxomavirus as a vector for the immunisation of sheep: protection study against challenge with bluetongue virus. Vaccine. 2012; 30(9); 1609-1616. [PubMed: 22244980].
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