• Vaccine Name: SL3261 expressing streptococcal M protein
• Target Pathogen: Streptococcus pyogenes
• Target Disease: Group A streptococcal infections, Strep throat, Scarlet fever
• Vaccine Ontology ID: VO_0004676
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector:
  • Vector name:
  • VO vector ID: VO_0001031
• Preparation: The aroA strain of S. typhimurium SL3261 was transformed with a low-copy plasmid vector pMK207, which contains the cloned gene spm5 encoding streptococcal M protein, the major virulence factor of these organisms (Poirier et al., 1988).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Mice were immunized orally with the pMK207-transformed Salmonella SL3261 (Poirier et al., 1988).
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• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Immunized and control mice were challenged intraperitoneally with either the homologous M5 or heterologous M24 streptococci, or with wild-type S typhimurium SL1344 (Poirier et al., 1988).
• Efficacy: The orally immunized mice were completely protected against both intranasal and intraperitoneal challenge infections with virulent S. typhimurium SL1344 or M5 streptococci (Poirier et al., 1988).