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Vaccine Detail
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Hsp70 chaperone-based gel composition |
| Vaccine Information |
- Vaccine Name: Hsp70 chaperone-based gel composition
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007615
- Type: Subunit vaccine
- Status: Research
- Preparation: Hydrogel-containing gel-forming substances and human recombinant Hsp70 applied on the surface of a 7-day-old B16F10 melanoma tumor (Abkin et al., 2013).
- Immunization Route: Intramuscular injection (i.m.)
- Description: The application of Hsp70 gel reduced the rate of tumor growth by 64% and prolonged the life of animals by 46% (Abkin et al., 2013).
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Immune Response: Increased survival was correlated with the enhancement of B16-specific cytotoxicity and up-regulation of gamma-interferon production (Abkin et al., 2013).
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| References |
Abkin et al., 2013: Abkin SV, Pankratova KM, Komarova EY, Guzhova IV, Margulis BA. Hsp70 chaperone-based gel composition as a novel immunotherapeutic anti-tumor tool. Cell stress & chaperones. 2013; 18(3); 391-396. [PubMed: 23233202].
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