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Vaccine Detail
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pcDNA3-MCC/ST |
| Vaccine Information |
- Vaccine Name: pcDNA3-MCC/ST
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004615
- Type: DNA vaccine
- Status: Research
- Antigen: MCPyV ST aa 1-186
- Preparation: Developed a MCPyV ST-expressing tumor cell line from B16 mouse melanoma cells. The DNA vaccine we generated encoded MCPyV ST aa 1-186 (pcDNA3-MCC/ST (Gomez et al., 2013).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Immune Response: ST-expressing tumor-bearing mice, this vaccine, pcDNA3-MCC/ST, generated a significant number of ST antigenic peptide-specific CD8+ T cells and experienced markedly enhanced survival compared to mice vaccinated with empty vector (Gomez et al., 2013).
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| References |
Gomez et al., 2013: Gomez B, He L, Tsai YC, Wu TC, Viscidi RP, Hung CF. Creation of a Merkel cell polyomavirus small T antigen-expressing murine tumor model and a DNA vaccine targeting small T antigen. Cell & bioscience. 2013; 3(1); 29. [PubMed: 23856459].
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