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Vaccine Detail
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pCR3.1-VS-HSP65-TP-GRP6-M2 |
| Vaccine Information |
- Vaccine Name: pCR3.1-VS-HSP65-TP-GRP6-M2
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004609
- Type: anti-GRP DNA
- Status: Research
- Antigen: GRP
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Human Response
- Vaccine Immune Response Type: VO_0003057
- Immune Response: inhibition of the proliferation of B16-F10 cells invading the lungs and suppression of tumor-associated angiogenesis, downregulation of PKC, resulting in antimetastatic effects, upregulation of wild-type p53, leading to the induction of apoptosis of B16-F10, which has very low levels of endogenous p53, or antigenic epitopes in degenerating B16-F10 cells engulfed by immune-activated antigen-presenting cells could be presented to cytotoxic T lymphocytes, leading to a potent immune response against the remaining tumor cells (Fang et al., 2009).
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| References |
Fang et al., 2009: Fang J, Lu Y, Ouyang K, Wu G, Zhang H, Liu Y, Chen Y, Lin M, Wang H, Jin L, Cao R, Roque RS, Zong L, Liu J, Li T. Specific antibodies elicited by a novel DNA vaccine targeting gastrin-releasing peptide inhibit murine melanoma growth in vivo. Clinical and vaccine immunology : CVI. 2009; 16(7); 1033-1039. [PubMed: 19458203].
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