• Vaccine Name: rBCG-SIVgag and rDIsSIVgag Prime-boost SHIV vaccine
• Target Pathogen: Human Immunodeficiency Virus
• Target Disease: Acquired Immunodeficiency Syndrome (AIDS)
• Vaccine Ontology ID: VO_0004600
• Type: Recombinant vector vaccine
• Status: Research
• Host Species as Laboratory Animal Model: cynomologus macaque
• Antigen: gag from simian immunodeficiency viruses
• gag gene engineering:
  • Type: Recombinant vector construction
  • Description: The SHIV gag gene was inserted to a recombinant BCG vector and a replication-deficient vaccinia virus strain (DIs) vaccine vector (Ami et al., 2005).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001023
  • Description: Mycobacterium bovis bacillus Calmette-Guérin (BCG)-Tokyo and a replication-deficient vaccinia virus strain (DIs) (Ami et al., 2005)
• Immunization Route: Intramuscular injection (i.m.)

Macaque Response

• Host Strain: cynomologus macaque
• Vaccination Protocol: cynomologus macaques were primed with rBCG-SIVgag, and then boosted with rDIsSIVgag (Ami et al., 2005).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Ten weeks after the second booster immunization, the macaques were challenged by intrarectal inoculation with 2 × 10^3 TCID50 or 50 50% monkey infectious doses (MID50) of SHIV KS661c, an SHIV-89.6 variant clone (Ami et al., 2005).
• Efficacy: For the prime-boost vaccination group, plasma viremia levels remained undetectable and CD4+ T-cell counts stayed above 500 cells/μl for the entire year of testing (Ami et al., 2005).