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Vaccine Detail

IBV DNA vaccine pVAX1-N
Vaccine Information
  • Vaccine Name: IBV DNA vaccine pVAX1-N
  • Target Pathogen: Infectious Bronchitis Virus (IBV)
  • Target Disease: Infectious Bronchitis
  • Vaccine Ontology ID: VO_0004581
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chickens
  • N protein gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000024
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Chicken Response

  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: Priming with a DNA vaccine encoding nucleocapsid protein (pVAX1-N) and boosting with the inactivated IBV vaccine provided up to 86.7% rate of immune protection, compared to the lack of protection seen in the PBS-immunized group, where the death rate was 66.7% (Guo et al., 2010).
References
Guo et al., 2010: Guo Z, Wang H, Yang T, Wang X, Lu D, Li Y, Zhang Y. Priming with a DNA vaccine and boosting with an inactivated vaccine enhance the immune response against infectious bronchitis virus. Journal of virological methods. 2010; 167(1); 84-89. [PubMed: 20307574].