• Vaccine Name: N. meningitidis DNA vaccine P3A
• Target Pathogen: Neisseria meningitidis
• Target Disease: Meningitis
• Vaccine Ontology ID: VO_0004569
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Antigen: a T-cell helper epitope and a peptide mimic of N. meningitidis serogroup C (Prinz et al., 2003)
• gp120 gene engineering:
  • Type: DNA vaccine construction
  • Description: The T-cell epitope used was from HIV gp120 (Prinz et al., 2003).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000158
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0003057
• Immune Response: Mice immunized with P3A DNA produced an anti-MCPS IgM antibody response that was significantly higher (P < 0.05) than that of mice immunized with P3C DNA (negative control) (Prinz et al., 2003).
• Efficacy: Mice immunized with P3A DNA were protected against meningococcal infection, with 100% survival. Five of the six mice immunized with P3C DNA (negative control) died within 24 hr postchallenge (Prinz et al., 2003).