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Vaccine Detail

IBV DNA vaccine pVAX1-16S1/M/N
Vaccine Information
  • Vaccine Name: IBV DNA vaccine pVAX1-16S1/M/N
  • Target Pathogen: Infectious Bronchitis Virus (IBV)
  • Target Disease: Infectious Bronchitis
  • Vaccine Ontology ID: VO_0004535
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chickens
  • Antigen: S1, N, and M proteins of the virulent IBVSX16 strain (Yan et al., 2013)
  • M membrane protein gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • N protein gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • S1 gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000024
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Chicken Response

  • Vaccination Protocol: Chickens were immunized with the multivalent DNA vaccine twice and then boosted with an inactivated vaccine once (Yan et al., 2013).
  • Immune Response: Antibody titers of the chickens immunized with pVAX1-16S1/M/N were much higher than those of the monovalent groups (p < 0.01) (Yan et al., 2013).
  • Efficacy: A protective rate up to 90% was observed in the pVAX1-16S1/M/N group (Yan et al., 2013).
References
Yan et al., 2013: Yan F, Zhao Y, Hu Y, Qiu J, Lei W, Ji W, Li X, Wu Q, Shi X, Li Z. Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine. Journal of veterinary science. 2013; 14(1); 53-60. [PubMed: 23388447].