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Vaccine Detail

Human papillomavirus DNA vaccine hCRTE6E7L2 DNA encoding CRT linked to E6, E7 and L2
Vaccine Information
  • Vaccine Name: Human papillomavirus DNA vaccine hCRTE6E7L2 DNA encoding CRT linked to E6, E7 and L2
  • Target Pathogen: Human Papillomavirus
  • Target Disease: HPV infection
  • Vaccine Ontology ID: VO_0004475
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • E6 Type 16 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pNGVL4a vector (National Gene Vector lab) expressed human calreticulin (CRT) linked to HPV16 early proteins, E6 and E7 and the late protein L2 (hCRTE6E7L2) (Kim et al., 2008).
    • Detailed Gene Information: Click Here.
  • E7 Type 16 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pNGVL4a vector (National Gene Vector lab) expressed human calreticulin (CRT) linked to HPV16 early proteins, E6 and E7 and the late protein L2 (hCRTE6E7L2) (Kim et al., 2008).
    • Detailed Gene Information: Click Here.
  • L2 HPV 16 gene engineering:
    • Type: Recombinant protein preparation
    • Description: Vector pNGVL4a vector (National Gene Vector lab) expressed human calreticulin (CRT) linked to HPV16 early proteins, E6 and E7 and the late protein L2 (hCRTE6E7L2) (Kim et al., 2008).
    • Detailed Gene Information: Click Here.
  • CRTC gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pNGVL4a vector (National Gene Vector lab) expressed human calreticulin (CRT) linked to HPV16 early proteins, E6 and E7 and the late protein L2 (hCRTE6E7L2) (Kim et al., 2008).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0005014
  • Immunization Route: Gene gun
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Immunization with DNA vaccines expressing hCRTE6E7 and hCRTE6E7L2 induced a higher percentage of tumor-free mice compared to immunization with the other DNA vaccines (Kim et al., 2008).
References
Kim et al., 2008: Kim D, Gambhira R, Karanam B, Monie A, Hung CF, Roden R, Wu TC. Generation and characterization of a preventive and therapeutic HPV DNA vaccine. Vaccine. 2008; 26(3); 351-360. [PubMed: 18096279].