• Vaccine Name: Prostate cancer DNA vaccine PSCA-HSP encoding PSCA and HSP
• Target Pathogen: Cancer
• Target Disease: Cancer
• Vaccine Ontology ID: VO_0004450
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• HSP47 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pcDNA3.1(+) expressed heat shock proteins (Zhang et al., 2007).
  • Detailed Gene Information: Click Here.
• Prostate stem cell antigen gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pcDNA3.1(+) expressed prostate stem cell antigen (PSCA) (Zhang et al., 2007).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000158
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: The growth of RM-PSCA tumors was significantly slower in the groups vaccinated with PSCA-HSP, HSP-PSCA, and PSCA + HSP plasmids compared with that in the groups treated with PBS or pcDNA-HSP (P < 0.05). Furthermore, the survival time of mice vaccinated with PSCA-HSP (range 40–69 days) was significantly longer as compared with that of groups injected with HSP-PSCA and PSCA + HSP plasmids (P = 0.016 and P = 0.015, respectively) (Zhang et al., 2007).