• Vaccine Name: Prostate cancer DNA vaccine pVax-PSA
• Target Pathogen: Cancer
• Target Disease: Cancer
• Vaccine Ontology ID: VO_0004448
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Prostate specific antigen gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pVAX1 expressed prostate -specific antigen (Roos et al., 2005).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000024
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: The pVax-PSA vaccine alone protected 40% of the mice from tumor growth. When either of the cytokine adjuvants (IL-2 or GM-CSF) was co-administered 60% of the mice were protected and when both adjuvants were simultaneously co-administered 80% of the mice were protected. All groups of mice that received the vaccine pVax-PSA (with or without cytokine adjuvants) were significantly different from the control group pVax (P < 0.01) (Roos et al., 2005).