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Vaccine Detail
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Melanoma DNA vaccine SINCp c-muMUC18 encoding MCAM/MUC18 |
| Vaccine Information |
- Vaccine Name: Melanoma DNA vaccine SINCp c-muMUC18 encoding MCAM/MUC18
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004436
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Mcam
gene engineering:
- Type: DNA vaccine construction
- Description: Vector SINCp expressed murine melanoma cell adhesion molecule (MCAM/MUC18) (Leslie et al., 2007).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005016
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Mice vaccinated with SINCp c-muMUC18 had significantly (P=0.037) fewer lung colonies than mice vaccinated with SINCp -gal. The number of lung metastases was reduced in mice vaccinated with SINCp c-muMUC18 (range 0–100; median 1.0) compared with SINCp -gal (range 18–200; median 26). Thus, mice immunized with SINCp c-muMUC18 were significantly protected from lung metastasis formation (Leslie et al., 2007).
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| References |
Leslie et al., 2007: Leslie MC, Zhao YJ, Lachman LB, Hwu P, Wu GJ, Bar-Eli M. Immunization against MUC18/MCAM, a novel antigen that drives melanoma invasion and metastasis. Gene therapy. 2007; 14(4); 316-323. [PubMed: 17024104].
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