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Vaccine Detail

Pristane-induced arthritis DNA vaccine DNA-hsp65 encoding Mycobacterium leprae 65-kDa heat shock protein
Vaccine Information
  • Vaccine Name: Pristane-induced arthritis DNA vaccine DNA-hsp65 encoding Mycobacterium leprae 65-kDa heat shock protein
  • Target Pathogen: Arthritis
  • Vaccine Ontology ID: VO_0004408
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • hsp65 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pcDNA3 expressed hsp65 from M. leprae (Santos-Junior et al., 2005).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000132
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: Cellular and humoral immune responses to the protein are elicited, and long-lived memory lymphocytes are induced (Santos-Junior et al., 2005).
  • Efficacy: DNA-hsp65 vaccination was protective against arthritis in AIRmax mice (maximal acute inflammatory reaction), as evidenced by the absence of arthritis incidence during the 150-day follow-up period. This protective effect was more pronounced after the onset of pristane-induced arthritis (Santos-Junior et al., 2005).
References
Santos-Junior et al., 2005: Santos-Junior RR, Sartori A, De Franco M, Filho OG, Coelho-Castelo AA, Bonato VL, Cabrera WH, Ibañez OM, Silva CL. Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis. Human gene therapy. 2005; 16(11); 1338-1345. [PubMed: 16259568].