• Vaccine Name: Autoimmune diabetes DNA vaccine pND2-SGAD55
• Target Pathogen: Diabetes
• Target Disease: Diabetes
• Vaccine Ontology ID: VO_0004403
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• GAD65 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pND2 expressed sgad55, a modified gad65 cDNA encoding a secreted truncated form of human GAD65 (Filippova et al., 2001).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000293
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0003057
• Efficacy: A Kaplan- Meier plot of diabetes onset, together with statistical analysis, indicated that mice that received injection of pND2- SGAD55 plasmid DNA had a significant reduction in diabetes compared with untreated control animals (P = 0.05; log-rank test). In contrast, mice that received pND2-GAD65 did not show significant diabetes reduction compared with the same controls (P = 0.37; log-rank test) (Filippova et al., 2001).